Affinage

POM121

Nuclear envelope pore membrane protein POM 121 · UniProt Q96HA1

Length
1249 aa
Mass
127.7 kDa
Annotated
2026-06-10
32 papers in source corpus 22 papers cited in narrative 23 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

POM121 is an integral membrane nucleoporin that functions both as a structural seed for nuclear pore complex (NPC) assembly and as a selective regulator of nuclear protein import (PMID:16702234, PMID:30100187). Its membrane topology orients the bulk C-terminal mass toward the pore side of the nuclear membrane while the N-terminus resides in the perinuclear space, and an N-terminal segment directs ER membrane retention that contributes to sorting toward nuclear pores (PMID:7525291, PMID:12651151). During post-mitotic NE reformation in reconstituted Xenopus systems, POM121 is dispensable for membrane vesicle binding to chromatin but essential for the membrane fusion that closes the NE; this requirement is gated by the Nup107-160 complex, whose co-depletion makes POM121 unnecessary, defining a checkpoint linking NPC assembly state to NE closure (PMID:15629719). POM121 is recruited downstream of chromatin-bound ELYS and the Nup107-160 complex through a direct interaction between its cytoplasmic domain and Nup107-160, and it can nucleate substructure assembly by recruiting nucleoporins such as Nup62 and Nup358 to ectopic sites (PMID:16702234, PMID:18596237). In interphase, POM121 seeds new NPCs from the inner nuclear membrane: its NLS sequences bind importin α/β in a RanGTP-dependent manner to target the protein to the INM, where it engages the INM and lamin B receptor and transiently associates with Sun1 to initiate de novo assembly; importin-β reciprocally limits POM121 chromatin binding (PMID:21289085, PMID:21727197, PMID:22100917). Beyond architecture, POM121 acts as a rate-limiting determinant of importin-β-dependent nuclear import for a range of transcription factors, promoting nuclear entry of E2F1, MYC, and the AR-GATA2 complex to drive prostate cancer aggressiveness, restraining NF-κB p65 and PPARγ nuclear accumulation, and supporting TFEB and ATF3 import (PMID:30100187, PMID:30802453, PMID:38177114, PMID:35507432, PMID:40480424). This import gateway is modulated by SIGMAR1 chaperoning that facilitates KPNB1 recruitment, by O-GlcNAcylation at Ser199 that antagonizes TRIM21-mediated ubiquitination to stabilize POM121, and by H3K18-lactylation-driven transcriptional upregulation (PMID:35507432, PMID:41629644, PMID:41864048). Loss of POM121 is the initiating event in a nucleoporin cascade and nucleocytoplasmic transport collapse in C9orf72 ALS/FTD neurons (PMID:32673563).

Mechanistic history

Synthesis pass · year-by-year structured walk · 17 steps
  1. 1994 Medium

    Established the membrane topology of POM121, defining how this transmembrane nucleoporin is oriented within the pore membrane — a prerequisite for understanding its anchoring and interaction surfaces.

    Evidence Differential antibody accessibility in semi-intact versus permeabilized cells

    PMID:7525291

    Open questions at the time
    • No high-resolution structural model of the membrane-spanning region
    • Functional contribution of the perinuclear N-terminus not defined
  2. 2003 Medium

    Identified an N-terminal ER membrane retention determinant, showing how POM121 is sorted away from the secretory pathway toward nuclear pores.

    Evidence GFP-tagged deletion mutants with FRAP, FLIP, and 15°C block in live cells

    PMID:12651151

    Open questions at the time
    • Molecular mechanism of retention not identified
    • Link between ER retention and INM targeting not directly demonstrated
  3. 2005 High

    Demonstrated that POM121 is essential for NE membrane fusion during assembly and revealed a checkpoint coupling its requirement to Nup107-160, establishing the order between NPC assembly and NE closure.

    Evidence Xenopus in vitro NE assembly with immunodepletion and double-depletion epistasis

    PMID:15629719

    Open questions at the time
    • Molecular basis of the membrane fusion step not defined
    • How Nup107-160 status bypasses POM121 requirement unresolved
  4. 2006 High

    Showed POM121 can nucleate NPC substructure assembly by recruiting Nup62 and Nup358, while also revealing functional redundancy since NPCs persist after depletion.

    Evidence Single and double siRNA knockdown and ectopic NPC assembly assay in HeLa and fibroblasts

    PMID:16702234

    Open questions at the time
    • Identity of redundant membrane-integral anchors not determined
    • Direct binding interfaces for Nup62/Nup358 recruitment not mapped
  5. 2008 High

    Placed POM121 recruitment downstream of ELYS/Nup107-160 in the assembly hierarchy via a direct cytoplasmic-domain interaction, ordering the early steps of NPC formation.

    Evidence Xenopus in vitro assembly with immunodepletion/add-back and pulldown of POM121 cytoplasmic domain with Nup107-160

    PMID:18596237

    Open questions at the time
    • Stoichiometry and affinity of the POM121–Nup107-160 interaction not quantified
    • Structural details of the interaction interface unknown
  6. 2009 Medium

    Distinguished POM121 from NDC1 by showing POM121 is not the anchor for ALADIN, refining the division of labor among transmembrane nucleoporins.

    Evidence siRNA knockdown and FRET in GFP-ALADIN HeLa cells

    PMID:19782045

    Open questions at the time
    • Full set of POM121-anchored nucleoporins not defined
  7. 2011 High

    Defined an importin α/β-dependent NLS mechanism that targets POM121 to the inner nuclear membrane to seed interphase NPC assembly, with INM/lamin B receptor and Sun1 contributions, establishing a distinct de novo assembly pathway.

    Evidence Cell-fusion NPC assembly assay, NLS/domain mutagenesis, fractionation, and Sun1 co-localization/knockdown

    PMID:21289085 PMID:21727197

    Open questions at the time
    • Transience and direct nature of POM121–Sun1 interaction not biochemically confirmed
    • How RanGTP gradient spatially restricts INM targeting unresolved
  8. 2011 High

    Showed importin-β negatively regulates POM121 chromatin binding through its NLS, providing a regulatory logic for spatial control of assembly seeding.

    Evidence Xenopus cell-free assembly with dominant-negative POM121 fragment, SEM, and importin-β assay

    PMID:22100917

    Open questions at the time
    • Endogenous chromatin binding sites of POM121 not molecularly defined
    • Relationship between this chromatin binding and ELYS seeding sites unclear
  9. 2015 Medium

    Demonstrated evolutionary conservation of POM121's active INM-import NLS by functional substitution for the yeast Heh2 NLS, supporting a conserved transport-factor-mediated INM targeting mechanism.

    Evidence Cross-species NLS rescue in yeast and reporter localization in HEK293T cells

    PMID:26179916

    Open questions at the time
    • Structural model based on comparison, not direct POM121 structure
  10. 2018 High

    Reframed POM121 as a rate-limiting importin-β-dependent gateway for nuclear import of oncogenic transcription factors (E2F1, MYC, AR-GATA2), linking nuclear transport capacity to cancer aggressiveness.

    Evidence Loss-of-function genetic screen, nuclear transport assays, importazole inhibition, patient-derived xenografts

    PMID:30100187

    Open questions at the time
    • Whether cargo selectivity is direct or via altered NPC composition not resolved
    • Mechanism distinguishing oncogenic cargoes from bulk import unknown
  11. 2019 Medium

    Extended POM121's import-regulatory role to immune signaling, showing it restrains nuclear accumulation of phospho-p65 to dampen NF-κB-driven inflammation.

    Evidence Macrophage-specific conditional knockout mice, LPS challenge, phospho-p65 Western blot, cytokine measurement

    PMID:30802453

    Open questions at the time
    • Direct interaction of POM121 with p65 import machinery not shown
    • How POM121 selectively limits p65 import unclear
  12. 2020 Medium

    Identified POM121 loss as the initiating event in a nucleoporin-depletion cascade and Ran disruption in C9orf72 ALS/FTD neurons, positioning it at the apex of nucleocytoplasmic transport failure.

    Evidence Super-resolution SIM of nucleoporins and siRNA in iPSC-derived neurons

    PMID:32673563

    Open questions at the time
    • Mechanism by which G4C2 RNA reduces POM121 not defined
    • Causal chain from POM121 loss to downstream Nup decrease not fully resolved
  13. 2022 Medium

    Defined SIGMAR1 as a chaperone that supports POM121-dependent KPNB1 recruitment to enable TFEB nuclear import and autophagy, with disruption in C9orf72 disease.

    Evidence Co-IP, overexpression/siRNA, pridopidine activation, nuclear TFEB/KPNB1/LC3-II Western blots

    PMID:35507432

    Open questions at the time
    • Direct biochemical nature of SIGMAR1-POM121 chaperoning not structurally defined
    • Single-lab Co-IP without reciprocal structural validation
  14. 2024 Medium

    Showed POM121 cytoplasmically sequesters PPARγ via a region downstream of its NLS, so that POM121 loss enforces PPARγ nuclear accumulation and growth arrest in colorectal cancer.

    Evidence CRISPR/Cas9 and siRNA silencing, nuclear fractionation, target gene expression, peptide interaction mapping

    PMID:38177114

    Open questions at the time
    • Direct binding affinity and structure of POM121-PPARγ interaction not determined
    • Generality of cytoplasmic sequestration versus import gating unresolved
  15. 2024 Low

    Reported a pathological structural repositioning of POM121 from the nuclear ring to the inner ring in C9orf72 ALS neurons, hinting at architectural remodeling of the NPC under disease.

    Evidence pan-Expansion Microscopy with machine-learning NPC sub-ring segmentation (preprint)

    Open questions at the time
    • Single imaging method in a preprint with no functional follow-up
    • Functional consequence of repositioning unknown
  16. 2025 Medium

    Defined a Sigma-1R/POM121/ATF3 protective axis in which poly-PR-induced POM121 loss mislocalizes ATF3 and damages the NE, while POM121 restoration rescues toxicity.

    Evidence siRNA/overexpression in NSC-34 cells, AAV-poly-PR mouse model, nuclear fractionation, ATF3 immunofluorescence, viability assays

    PMID:40480424

    Open questions at the time
    • Mechanism of Sigma-1R-mediated POM121 stabilization under oxidative stress not biochemically defined
    • Whether ATF3 mislocalization is direct POM121-dependent import not shown
  17. 2026 Medium

    Established post-translational and transcriptional control of POM121 abundance: O-GlcNAcylation at Ser199 blocks TRIM21-mediated degradation, and H3K18 lactylation upregulates transcription, both increasing POM121-driven oncogenic import.

    Evidence MS site mapping with Ser199 mutagenesis, POM121-TRIM21 Co-IP and ubiquitination assays, c-MYC import assays; ChIP and dual-luciferase reporter with LDHA/LDHB silencing and rescue

    PMID:41629644 PMID:41864048

    Open questions at the time
    • Whether OGT and lactylation pathways converge on the same POM121 pool not addressed
    • Structural impact of Ser199 modification on TRIM21 binding not resolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • How POM121 achieves cargo selectivity — distinguishing specific oncogenic and signaling transcription factors from bulk nuclear import — and how its dual roles in NPC architecture versus selective import are mechanistically separated remain open.
  • No structure of POM121 cargo-discriminating interfaces
  • Relationship between altered NPC composition and import selectivity unresolved
  • Whether disease-associated import defects reflect loss of structural seeding or loss of import gating not separated

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 3 GO:0060089 molecular transducer activity 3 GO:0140104 molecular carrier activity 3
Localization
GO:0005635 nuclear envelope 3 GO:0005783 endoplasmic reticulum 1
Pathway
R-HSA-1643685 Disease 3 R-HSA-1852241 Organelle biogenesis and maintenance 3 R-HSA-9609507 Protein localization 3
Partners
KPNB1NUP107NUP358NUP62SIGMAR1SUN1TRIM21
Complex memberships
Nuclear pore complex (NPC)

Evidence

Reading pass · 23 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1994 POM121 membrane topology was established: the large C-terminal region (>90% of total mass) faces the pore side (cytoplasmic side) of the nuclear membrane, while the N-terminal portion resides in the perinuclear space, determined by differential antibody accessibility in semi-intact versus permeabilized cells. Indirect immunofluorescence with epitope-specific antibodies in semi-intact and permeabilized cells European journal of cell biology Medium 7525291
1996 The C-terminal portion of POM121, containing the pentapeptide repeat domain, is sufficient for targeting to the nuclear envelope and for formation of intranuclear bodies when overexpressed; overexpressed POM121 accumulates in novel cylindrical intranuclear structures adjacent to the inner nuclear membrane. Immunofluorescence and fluorescence digital imaging microscopy of heterologously overexpressed POM121 deletion constructs in COS cells Experimental cell research Medium 8635519
2003 Amino acids 1–129 of POM121 retain a GFP fusion in the ER membrane by a direct retention mechanism (not retrieval), preventing its exit to the Golgi or plasma membrane; this ER retention likely contributes to sorting of POM121 to nuclear pores. GFP-tagged deletion mutant localization, FRAP, FLIP, 15°C block experiments in live cells Experimental cell research Medium 12651151
2004 POM121 is specifically degraded during apoptosis by a caspase-3-dependent process; a caspase-resistant mutant of POM121-GFP resisted degradation and was detected in clustered nuclear pores even in late apoptosis, placing POM121 cleavage upstream of phosphatidylserine externalization. Live-cell imaging of POM121-GFP and caspase-resistant mutant, annexin V labeling temporal comparison Apoptosis Medium 15258468
2005 POM121, but not gp210, is essential for nuclear envelope (NE) formation in Xenopus in vitro NE assembly assays; depletion of POM121-containing membrane vesicles or the protein itself does not affect vesicle binding to chromatin but prevents membrane fusion to form a closed NE. When the Nup107-160 complex is co-depleted, POM121 becomes dispensable, revealing a functional checkpoint linking NPC assembly state to NE formation. Xenopus in vitro NE assembly assay with immunodepletion of POM121 and Nup107-160 complex, epistasis analysis Molecular cell High 15629719
2006 POM121 can recruit nucleoporins Nup62 and Nup358 to ectopic assembly sites, acting as a nucleation site for NPC substructure assembly. However, functional NPCs and intact NEs persist in severely POM121-depleted cells, and POM121/gp210 double knockdown still supports NPC assembly, indicating extensive redundancy and additional membrane-integral anchoring proteins. siRNA knockdown (single and double) in HeLa cells and human fibroblasts; ectopic NPC assembly assay The Journal of cell biology High 16702234
2007 In human HeLa cells, two distinct POM121 gene loci each produce full-length Pom121 protein; RNAi depletion of both significantly reduces the number of assembled NPCs on the nuclear envelope and induces NPC clustering, demonstrating a role in NPC maintenance and organization. RNAi depletion of both POM121 paralogs, quantitative NPC counting by immunofluorescence FEBS letters Medium 17900573
2008 Recruitment of membrane vesicles containing POM121 (and NDC1) to the forming nucleus is dependent on chromatin-bound ELYS/Nup107-160 complex; a direct interaction between the cytoplasmic domain of POM121 and the Nup107-160 complex was identified, placing POM121 recruitment downstream of ELYS and Nup107-160 in the NPC assembly order. Xenopus in vitro NPC assembly with immunodepletion and add-back, interaction between POM121 cytoplasmic domain and Nup107-160 complex by pulldown Molecular biology of the cell High 18596237
2009 Depletion of POM121 (or gp210) does not affect the NPC localization of ALADIN nucleoporin; NDC1, not POM121 or GP210, is the main anchor for ALADIN within the NPC, as shown by siRNA knockdown and FRET measurements. siRNA knockdown in stably expressing GFP-ALADIN HeLa cells; FRET measurements Biochemical and biophysical research communications Medium 19782045
2010 Pom121 contains functional nuclear localization signals (NLS) that bind importin α/β; these NLS sites mediate interactions with a group of nucleoporins in an NLS-dependent manner. In vivo replacement of Pom121 with an NLS mutant version caused defective nuclear transport, aberrant cytoplasmic membrane stacks, and decreased cell viability. Co-immunoprecipitation, NLS mutagenesis, in vivo rescue assay FEBS letters Medium 20624389
2011 POM121 is present at new NPC assembly sites during interphase coinciding with inner and outer nuclear membrane fusion; overexpression of POM121 causes juxtaposition of the INM and ONM. Sun1, an INM protein, is specifically required for interphase NPC assembly and colocalizes with POM121 at forming pores, suggesting a transient POM121-Sun1 interaction promotes early interphase NPC assembly. Live-cell imaging, overexpression, siRNA knockdown of Sun1 and POM121, colocalization by fluorescence microscopy The Journal of cell biology Medium 21727197
2011 Pom121 is indispensable for an early step in interphase NPC assembly; its NLS sequences bind importin β via importin α (RanGTP-dependent) and are essential for targeting Pom121 to interphase NPCs. A domain of Pom121 that interacts with the INM and lamin B receptor is required for NPC targeting. Pom121 localizes at the INM in the absence of a complete NPC, supporting a model where INM-seeded Pom121 initiates interphase NPC assembly. siRNA plus cell fusion-based NPC assembly assay; domain deletion and NLS mutagenesis; fractionation and colocalization Molecular biology of the cell High 21289085
2011 A soluble internal fragment of POM121 acts as a dominant-negative inhibitor of both mitotic and interphase NPC assembly in a cell-free reconstitution system; it binds chromatin at sites distinct from ELYS-Nup107-160 seeding sites and prevents membrane enclosure. Importin-β negatively regulates chromatin binding by this POM121 fragment through a conserved NLS motif, and also affects endogenous POM121 recruitment to chromatin. Xenopus cell-free NPC assembly reconstitution, dominant-negative fragment, scanning electron microscopy, importin-β regulation assay Journal of cell science High 22100917
2015 The NLS of RnPom121 can functionally substitute for the NLS of yeast Heh2 in driving INM localization in yeast cells and rescues the subcellular localization and synthetic sickness of Heh2ΔNLS mutants; the NLS adopts a similar fold as the Heh2 NLS when transport-factor bound, confirming evolutionary conservation of active INM import. Cross-species NLS rescue experiments in yeast; structural comparison; reporter localization in HEK293T cells Molecular biology of the cell Medium 26179916
2018 POM121 promotes nuclear import of key oncogenic transcription factors E2F1, MYC, and the androgen receptor (AR)-GATA2 complex via importin-dependent nuclear transport in prostate cancer cells; loss-of-function genetic screen identified POM121 as a key contributor to prostate cancer aggressiveness, and pharmacological inhibition of importin β decreased tumor growth and restored therapy efficacy in patient-derived models. Focused loss-of-function genetic screen, nuclear transport assays, importazole pharmacological inhibition, patient-derived xenograft models Cell High 30100187
2019 POM121 inhibits NF-κB signaling in macrophages by repressing nuclear accumulation of phosphorylated P65; conditional knockout of POM121 in macrophages (POM121fl/fl Lyzm-Cre+ mice) increased susceptibility to LPS-induced acute lung injury with elevated TNF-α and IL-6. Macrophage-specific conditional knockout mouse, LPS stimulation, Western blot for phos-P65 nuclear localization, cytokine measurement Experimental cell research Medium 30802453
2020 In C9orf72 ALS/FTD iPSC-derived neurons, expanded G4C2 repeat RNA reduces POM121 expression, which initiates a cascade decreasing seven additional nucleoporins, disrupts Ran GTPase localization, and leads to cellular toxicity; POM121 reduction is the initiating event in this pathological nucleoporin cascade. Super-resolution structured illumination microscopy of nucleoporins in iPSNs, siRNA-mediated reduction of POM121, quantification of 23 nucleoporins Neuron Medium 32673563
2022 SIGMAR1 (Sigma-1 receptor) chaperones POM121 at the nuclear pore, facilitating KPNB1/importin-β1 recruitment and thereby enabling TFEB nuclear transport for autophagy induction; in C9orf72 ALS-FTD cells, HRE disrupts the SIGMAR1-POM121 interaction, reducing nuclear TFEB, KPNB1, and LC3-II; overexpression of SIGMAR1, POM121, or SIGMAR1 agonist pridopidine rescues these deficits. Co-immunoprecipitation, overexpression, siRNA, pharmacological activation (pridopidine), Western blot for nuclear TFEB/KPNB1/LC3-II Autophagy Medium 35507432
2024 A peptide region downstream of the NLS of POM121 acts as a cytoplasmic interactor of PPARγ; CRISPR/Cas9 or siRNA silencing of POM121A/C enforces nuclear accumulation of PPARγ and activates PPARγ target genes promoting lipid metabolism and cell cycle arrest, reducing CRC cell proliferation. CRISPR/Cas9 and siRNA silencing, nuclear fractionation, PPARγ target gene expression analysis, peptide interaction mapping Cell death & disease Medium 38177114
2024 In C9orf72 ALS iPSC-derived neurons, POM121 shifts from the nuclear ring to the inner ring position within the NPC as visualized by pan-Expansion Microscopy, indicating a structural repositioning of POM121 within the NPC architecture under pathological conditions. pan-Expansion Microscopy with machine-learning segmentation of NPC sub-rings bioRxiv (preprint)preprint Low
2025 Poly-PR dipeptide repeat protein reduces Pom121 expression in motor neurons (NSC-34 cells and AAV-poly-PR42 mouse model), causing cytoplasmic mislocalization of ATF3 transcription factor and nuclear envelope damage; Pom121 overexpression restores nuclear ATF3 localization and alleviates poly-PR toxicity. Sigma-1R stabilizes Pom121 under oxidative stress, defining a Sigma-1R/Pom121/ATF3 protective axis. siRNA/overexpression in NSC-34 cells, AAV mouse model, nuclear fractionation, immunofluorescence for ATF3 localization, cell viability assays Neurobiology of disease Medium 40480424
2026 O-GlcNAcylation of POM121 at Ser199 (by OGT) attenuates its interaction with E3 ubiquitin ligase TRIM21, thereby preventing ubiquitination and stabilizing POM121 protein; accumulated POM121 then enhances nuclear import of c-MYC, which transcriptionally activates ECM-related genes driving NSCLC bone metastasis. Mass spectrometry identification of O-GlcNAcylation site, mutagenesis (Ser199), Co-IP of POM121-TRIM21 interaction, ubiquitination assay, nuclear import assay for c-MYC Oncogene Medium 41629644
2026 H3K18 lactylation enrichment at the POM121 promoter region drives enhanced POM121 transcription in gastric cancer, as demonstrated by ChIP and dual-luciferase reporter assays; reduced H3K18la (via LDHA/LDHB silencing) decreases POM121 expression and suppresses tumor progression, which is rescued by POM121 overexpression. ChIP assay, dual-luciferase reporter assay, LDHA/LDHB siRNA, POM121 overexpression rescue Pathology, research and practice Medium 41864048

Source papers

Stage 0 corpus · 32 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2018 Nuclear Pores Promote Lethal Prostate Cancer by Increasing POM121-Driven E2F1, MYC, and AR Nuclear Import. Cell 134 30100187
2008 Capture of AT-rich chromatin by ELYS recruits POM121 and NDC1 to initiate nuclear pore assembly. Molecular biology of the cell 134 18596237
2005 The integral membrane nucleoporin pom121 functionally links nuclear pore complex assembly and nuclear envelope formation. Molecular cell 129 15629719
2020 G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD. Neuron 128 32673563
2011 POM121 and Sun1 play a role in early steps of interphase NPC assembly. The Journal of cell biology 112 21727197
2011 Localization of Pom121 to the inner nuclear membrane is required for an early step of interphase nuclear pore complex assembly. Molecular biology of the cell 79 21289085
2006 Nuclear pore complex assembly and maintenance in POM121- and gp210-deficient cells. The Journal of cell biology 61 16702234
2022 Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1/sigma-1 receptor chaperone by pridopidine. Autophagy 55 35507432
2010 NLS-mediated NPC functions of the nucleoporin Pom121. FEBS letters 49 20624389
1994 The large C-terminal region of the integral pore membrane protein, POM121, is facing the nuclear pore complex. European journal of cell biology 46 7525291
2007 Two distinct human POM121 genes: requirement for the formation of nuclear pore complexes. FEBS letters 41 17900573
2011 A dominant-negative form of POM121 binds chromatin and disrupts the two separate modes of nuclear pore assembly. Journal of cell science 34 22100917
2009 The nuclear pore complex protein ALADIN is anchored via NDC1 but not via POM121 and GP210 in the nuclear envelope. Biochemical and biophysical research communications 34 19782045
1995 POM-ZP3, a bipartite transcript derived from human ZP3 and a POM121 homologue. Genomics 30 7789967
2021 POM121 promotes proliferation and metastasis in non-small-cell lung cancer through TGF-β/SMAD and PI3K/AKT pathways. Cancer biomarkers : section A of Disease markers 22 34151840
2018 Targeting Nucleoporin POM121-Importin β Axis in Prostate Cancer. Cell chemical biology 21 30241601
2019 POM121 inhibits the macrophage inflammatory response by impacting NF-κB P65 nuclear accumulation. Experimental cell research 18 30802453
2015 Conservation of inner nuclear membrane targeting sequences in mammalian Pom121 and yeast Heh2 membrane proteins. Molecular biology of the cell 18 26179916
2022 CircINTS4 Facilitates Chemoresistance of TNBC by Competitively Binding miR-129-5p/POM121 Axis. Journal of oncology 16 35419056
1996 Formation of nuclear bodies in cells overexpressing the nuclear pore protein POM121. Experimental cell research 15 8635519
2024 Nuclear pore protein POM121 regulates subcellular localization and transcriptional activity of PPARγ. Cell death & disease 13 38177114
2024 Fluvoxamine Exerts Sigma-1R to Rescue Autophagy via Pom121-Mediated Nucleocytoplasmic Transport of TFEB. Molecular neurobiology 12 38180612
2014 The imprinted NPAP1 gene in the Prader-Willi syndrome region belongs to a POM121-related family of retrogenes. Genome biology and evolution 11 24482533
2023 POM121 promotes the proliferation and metastasis of gastric cancer via PI3K/AKT/MYC pathway. American journal of cancer research 9 36895982
2020 Clinical Significance of POM121 Expression in Lung Cancer. Genetic testing and molecular biomarkers 8 33296260
2003 ER retention may play a role in sorting of the nuclear pore membrane protein POM121. Experimental cell research 8 12651151
2004 Degradation of GFP-labelled POM121, a non-invasive sensor of nuclear apoptosis, precedes clustering of nuclear pores and externalisation of phosphatidylserine. Apoptosis : an international journal on programmed cell death 6 15258468
2025 Sigma-1R-Pom121 axis preserves nuclear transport and integrity in poly-PR-induced C9orf72 ALS. Neurobiology of disease 2 40480424
2026 POM121 Drives Gastric Cancer Progression via the mTOR/p70S6K Signaling Axis. Anticancer research 0 41617438
2026 POM121 O-GlcNAcylation facilitates bone metastasis in non-small cell lung cancer through enhanced c-MYC nuclear import and ECM reprogramming. Oncogene 0 41629644
2026 H3K18 lactylation promotes POM121 transcription and accelerates gastric cancer progression via the PI3K/AKT pathway. Pathology, research and practice 0 41864048
2025 POM121 induces chemoresistance toward cisplatin in non-small cell lung cancer. Cytotechnology 0 41040129

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