Affinage

PATJ

InaD-like protein · UniProt Q8NI35

Length
1801 aa
Mass
196.4 kDa
Annotated
2026-06-10
38 papers in source corpus 24 papers cited in narrative 25 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PATJ (also INADL/CIPP/hINADL) is a multi-PDZ-domain scaffold protein that organizes apical-basal polarity and tight junctions in epithelial cells by assembling the Crumbs3–Pals1–PATJ complex (PMID:11964389, PMID:16129888). Its N-terminal L27 domain forms a heterodimer with the L27N domain of Pals1, and structural analysis shows these L27 modules build a tetrameric assembly in which cognate L27 pairs dock independently, providing the architectural basis for tripartite scaffold formation with partners such as MALS2 (PMID:15863617, PMID:22337881). Through this scaffold PATJ connects and stabilizes apical and lateral junction components: its loss displaces Pals1 from junctions, traps Crumbs3 in an apical endosomal compartment, and mislocalizes occludin and ZO-3 to the lateral membrane, delaying tight junction formation and disrupting polarity in a manner rescued by re-expression (PMID:15738264, PMID:16129888). PATJ is required for directional epithelial migration, positioning aPKC, Par3 and the MTOC at the leading edge (PMID:17235357), and for lumen formation in 3D cysts, where it shapes the apical-lateral border and connects the tight junction to the apical cortex. Beyond scaffolding, PATJ associates with and inhibits HDAC7 to control transcription of cell-junction and membrane-organization genes, a function independent of Pals1 binding (PMID:37878054). The seven PDZ domains have distinct C-terminal peptide specificities spanning class I, II, and a novel class IV (PMID:11509564), underlying a diverse partner repertoire: in neurons (as CIPP) PATJ clusters and increases surface activity of Kir4.1 channels, ASIC3, NMDA receptor subunits, and the 5-HT2B receptor (PMID:9647694, PMID:11872753, PMID:33739808); in endothelial cells it forms an Amot–PATJ–Syx complex that spatially targets RhoA activity to lamellipodia (PMID:18824598); and in T cells it supports immunological synapse formation and TCR signaling (PMID:40341028). PATJ is also a target of oncogenic HPV E6 proteins, which bind and degrade it (PMID:17287269). A homozygous truncating PATJ variant produces a ciliopathy with polycystic kidney disease and hydrocephalus in patient and zebrafish, establishing an essential role in cilia (PMID:40931526).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 1998 High

    Established that the protein (CIPP) is a multi-PDZ scaffold that selectively binds and functionally regulates neuronal ion channels and receptors, defining its earliest molecular identity.

    Evidence Yeast two-hybrid, GST pull-down, and whole-cell voltage clamp of Kir4.1/NMDA partners in COS-7 cells

    PMID:9647694

    Open questions at the time
    • Did not address epithelial junction roles
    • No structural basis for partner selection
  2. 2001 High

    Resolved how the seven PDZ domains achieve binding diversity, defining class I, II and a novel class IV specificity and explaining the protein's broad partner repertoire.

    Evidence Combinatorial phage-display peptide screening, homology modeling, and site-directed mutagenesis

    PMID:11509564

    Open questions at the time
    • Peptide preferences not all matched to physiological partners
    • No domain occupancy in cells
  3. 2002 High

    Connected PATJ to epithelial apical junctions by showing it binds Crumbs3 and localizes to tight junctions, recasting the neuronal scaffold as a polarity component.

    Evidence Co-IP, overexpression/dominant-negative, and immunofluorescence in Caco-2 cells; ASIC3 binding/electrophysiology in COS cells

    PMID:11872753 PMID:11964389

    Open questions at the time
    • Loss-of-function phenotype not yet tested
    • Mechanism of junction stabilization unknown
  4. 2005 High

    Demonstrated PATJ is functionally required for tight junction formation and polarity, and defined the structural L27–L27N heterodimer mechanism by which it binds Pals1.

    Evidence RNAi with rescue in MDCK/Caco2 cells, subcellular fractionation, and NMR solution structure of the L27 complex

    PMID:15738264 PMID:15863617 PMID:16129888

    Open questions at the time
    • How PATJ stabilizes lateral occludin/ZO-3 mechanistically unresolved
    • Stoichiometry of full complex in vivo unclear
  5. 2007 High

    Extended PATJ function to directional migration and identified it as a target of oncogenic HPV E6, linking polarity scaffold loss to viral pathogenesis.

    Evidence RNAi migration/MTOC assays in MDCKII cells; E6 binding/degradation and E6AP silencing in epithelial cells

    PMID:17235357 PMID:17287269

    Open questions at the time
    • E6AP-independent degradation pathway not identified
    • Direct link between migration defect and tumor phenotype untested
  6. 2008 High

    Showed PATJ spatially controls RhoA signaling by forming an Amot–PATJ–Syx complex in endothelial lamellipodia, generalizing its scaffolding role to GTPase regulation.

    Evidence Peptide pull-down, yeast two-hybrid, FRET RhoA biosensor, and zebrafish morpholino knockdown

    PMID:18824598

    Open questions at the time
    • Overlap/distinction from Mupp1-containing complexes not fully resolved
    • Mechanism of RhoA spatial restriction incomplete
  7. 2012 High

    Established direct enzymatic and structural mechanisms: Drosophila PATJ inhibits Myosin phosphatase to maintain junction-stabilizing Myosin activation, and crystallography defined independent L27 pair assembly in the tripartite complex.

    Evidence Pull-down/phosphorylation assays and genetic rescue in Drosophila; X-ray crystallography of L27 heterotrimer; domain-rescue and epistasis in Drosophila

    PMID:22337881 PMID:23128243 PMID:23136386

    Open questions at the time
    • Whether mammalian PATJ regulates Myosin phosphatase similarly untested
    • Tissue-specific dispensability (ectoderm vs follicle) mechanism unclear
  8. 2009 High

    Distinguished PATJ from its paralog MUPP1, showing shared partners but a non-redundant, indispensable PATJ role tied to higher Pals1 affinity, and linked PATJ to nephrocystins NPHP1/NPHP4.

    Evidence Comparative RNAi, affinity comparison, co-IP and 3D culture in epithelial/renal cells

    PMID:19138174 PMID:19255144 PMID:19755384

    Open questions at the time
    • NPHP linkage inferred from phenotypic similarity rather than direct PATJ epistasis
    • Functional consequence of PATJ–IRSp53 binding not resolved
  9. 2013 Medium

    Revealed reciprocal regulation between PATJ and MUPP1 pools and assembled neuronal CIPP–IRSp53–Cypin tripartite complexes at protrusion tips, expanding the scaffold model.

    Evidence siRNA depletion and co-IP in MCF10A cells; domain-mapped co-IP in neuronal cells

    PMID:20707603 PMID:23880463

    Open questions at the time
    • Single-lab, single experimental set for MUPP1/PATJ stability interplay
    • Physiological role of IRSp53–Cypin–CIPP complex untested
  10. 2023 Medium

    Uncovered a Pals1-independent transcriptional arm: PATJ inhibits HDAC7 to control junction/membrane gene expression and lumen formation, and PATJ/MPDZ govern blastocyst trophectoderm via Hippo/YAP.

    Evidence CRISPR KO with 3D cyst assay, PATJ–HDAC7 co-IP, inhibitor/siRNA rescue, RNA-seq; embryo RNAi with polarity and YAP readouts

    PMID:37318097 PMID:37878054

    Open questions at the time
    • How PATJ inhibits HDAC7 mechanistically unknown
    • Embryo study limited to single organism and double-depletion design
  11. 2025 Medium

    Connected PATJ to lumen ultrastructure, T-cell immunological synapse signaling, YAP1-linked stress transcription, and a human ciliopathy, broadening its physiological and disease relevance.

    Evidence BioID/EM lumen analysis in MDCK-II (preprint); conditional T-cell KO and CAR engineering; CRISPR KO/RNA-seq and C. elegans hypoxia; patient variant validated in zebrafish

    PMID:40341028 PMID:40472775 PMID:40931526

    Open questions at the time
    • Lumen role rests on a single preprint
    • Ciliopathy link based on a single variant/family
    • Mechanism connecting PATJ to ciliogenesis undefined

Open questions

Synthesis pass · forward-looking unresolved questions
  • How PATJ's distinct functional modules — Pals1-dependent junction scaffolding, Pals1-independent HDAC7 transcriptional control, RhoA/Myosin cytoskeletal regulation, and neuronal channel clustering — are partitioned and coordinated within a single cell remains unresolved.
  • No integrated model of how separate PATJ pools/domains are deployed
  • Mechanism of PATJ's role in ciliogenesis unknown
  • Direct enzymatic regulation of HDAC7 not characterized

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 5 GO:0060090 molecular adaptor activity 4 GO:0008092 cytoskeletal protein binding 2
Localization
GO:0005886 plasma membrane 2 GO:0005929 cilium 1
Pathway
R-HSA-1266738 Developmental Biology 3 R-HSA-162582 Signal Transduction 3
Partners
AMOTASIC3CRB3HDAC7IRSP53KCNJ10MPDZPALS1
Complex memberships
Amot-PATJ-Syx complexCrumbs3-Pals1-PATJ apical polarity complexL27 PATJ-Pals1-MALS2 heterotrimer

Evidence

Reading pass · 25 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2002 PATJ (hINADL) interacts with human Crumbs3 (CRB3) through the CRB3 C-terminal end binding to the N-terminal domain of PATJ, and localizes to tight junctions and apical plasma membrane in human intestinal epithelial cells; overexpression of PATJ disrupted ZO-1 and ZO-3 tight junction localization. Co-immunoprecipitation, overexpression/dominant-negative experiment, immunofluorescence localization in Caco-2 cells The Journal of biological chemistry High 11964389
2005 PATJ is targeted to the apical region and tight junctions upon initiation of cell polarization; RNAi-mediated reduction of PATJ delays tight junction formation and causes cell polarity defects, which are reversed by PATJ reintroduction, establishing PATJ as a functional polarity protein in mammalian epithelial cells. RNAi knockdown, rescue by reintroduction, immunofluorescence, tight junction formation assay in MDCK cells The Journal of cell biology High 15738264
2005 PATJ knockdown in Caco2 cells causes Pals1 to dissociate from tight junctions, Crumbs3 to accumulate in an early endosome-related compartment near the apical membrane, and mislocalization of occludin and ZO-3 to the lateral membrane, demonstrating that PATJ connects and stabilizes apical and lateral components of tight junctions. Stable shRNA knockdown, immunofluorescence, subcellular fractionation in Caco2 cells Journal of cell science High 16129888
2005 The L27 domain of PATJ forms a heterodimeric complex with the L27N domain of Pals1, assembling into a tetrameric structure (two heterodimer units); the C-terminal alpha-helix of each L27 domain is a critical specificity determinant for partner selection. NMR solution structure determination, biochemical binding assays, site-directed analysis of L27 domain complexes Proceedings of the National Academy of Sciences of the United States of America High 15863617
2007 PATJ is required for directional migration of epithelial cells; PATJ RNAi in MDCKII cells disrupts localization of aPKC and Par3 to the leading edge and disorganizes the microtubule-organizing center orientation during wound-induced migration. RNAi knockdown, wound-induced migration assay, immunofluorescence of aPKC/Par3 at leading edge, MTOC orientation analysis EMBO reports High 17235357
2007 HPV16 and HPV18 E6 proteins bind PATJ through E6's C-terminal PDZ-binding motif and target PATJ for degradation; additionally, the alternatively spliced 18 E6* isoform (lacking a C-terminal PDZ-binding motif) also associates with and degrades PATJ independently, and 18 E6-mediated PATJ degradation is not inhibited by shRNA silencing of E6AP. Co-immunoprecipitation, protein degradation assays, shRNA silencing of E6AP, isoform comparison experiments in epithelial cells Journal of virology High 17287269
2008 PATJ (and its paralogue Mupp1) forms a ternary complex with angiomotin (Amot) and the RhoA GEF Syx; this Amot:Patj/Mupp1:Syx complex controls spatial targeting of RhoA activity to lamellipodia in migrating endothelial cells. Peptide pull-down, yeast two-hybrid screening, FRET analysis of RhoA activity in lamellipodia, morpholino knockdown in zebrafish Blood High 18824598
1998 CIPP (PATJ/INADL) selectively binds via its PDZ domains to Kir4.1 and Kir4.2 inward rectifier K+ channels, NMDA receptor subunits, neurexins, and neuroligins; co-expression of CIPP with Kir4.1 in COS-7 cells doubles Kir4.1 current density. Yeast two-hybrid, GST pull-down, whole-cell voltage clamp electrophysiology in COS-7 cells Molecular and cellular neurosciences High 9647694
2002 CIPP (PATJ/INADL) PDZ4 domain interacts with ASIC3 C-terminal region; co-expression of CIPP with ASIC3 in COS cells increases ASIC3 peak current density 5-fold and slightly shifts pH0.5 from 6.2 to 6.4, consistent with enhanced surface expression of ASIC3. Yeast two-hybrid, co-immunoprecipitation, whole-cell patch-clamp electrophysiology in COS cells, in situ hybridization The Journal of biological chemistry High 11872753
2001 The seven PDZ domains of human INADL (PATJ) each have distinct binding specificities for C-terminal peptide ligands, falling into class I, class II, and a novel class IV (characterized by an acidic residue at the C-terminal position); site-directed mutagenesis of contact residues confirmed involvement of specific pocket residues in binding preference. Combinatorial phage-display peptide library screening, homology modeling, site-directed mutagenesis The Journal of biological chemistry High 11509564
2009 PATJ shares binding partners with MUPP1 including JAM1, ZO-3, Pals1, Par6, and nectins, and uses overlapping mechanisms for tight junction localization; however, unlike MUPP1, PATJ is indispensable for tight junction establishment and epithelial polarization, with Pals1 showing higher affinity for PATJ than MUPP1, and Pals1-mediated activation of the Par6-aPKC complex being critical for PATJ function. Co-immunoprecipitation, binding affinity comparison, RNAi knockdown of PATJ vs MUPP1, immunofluorescence Molecular and cellular biology High 19255144
2009 PATJ physically interacts with nephrocystin-1 (NPHP1) and nephrocystin-4 (NPHP4) and co-localizes with them in human renal tubules; knockdown of NPHP1 or NPHP4 phenocopies loss of PALS1/Par3, producing tight junction formation defects similar to those seen with PATJ/PALS1 depletion. Co-immunoprecipitation, shRNA knockdown in MDCK cells, immunofluorescence, 3D collagen matrix culture Human molecular genetics Medium 19755384
2012 Drosophila PATJ directly binds the Myosin-binding subunit (MBS) of Myosin phosphatase and decreases Myosin dephosphorylation, resulting in activated (phosphorylated) Myosin; this supports stability of the Zonula Adherens, and loss of PATJ leads sequentially to Myosin loss from AJ, AJ disassembly, and loss of apical-basal polarity. Direct binding assay (pull-down), Myosin phosphorylation assays, PATJ mutant analysis in Drosophila epithelium, immunofluorescence The Journal of cell biology High 23128243
2012 In Drosophila, the first PDZ domain of Patj together with its Stardust-binding (L27) domain are sufficient to fully rescue viability and Crumbs localization in null Patj mutants; Patj null mutants are lethal but Patj is dispensable for ectoderm polarity while being required in follicular epithelium where it supports Crumbs complex apical localization. Gain-of-function of Crumbs and Patj mutation genetically suppress each other in follicular cells. Generation of null Drosophila Patj mutants, domain truncation rescue experiments, genetic epistasis (Crumbs gain-of-function × Patj mutant), immunofluorescence Development (Cambridge, England) High 23136386
2012 Crystal structure of the L27(PATJ)-(L27N,L27C)(Pals1)-L27(MALS2) heterotrimer reveals two cognate pairs of heterodimeric L27 domains that assemble mutually independently; biochemical data confirm this independent assembly mode also applies to DLG1/CASK/Mals2. X-ray crystallography (2.05 Å resolution), biochemical binding assays The Journal of biological chemistry High 22337881
2013 MUPP-1 levels inversely regulate PATJ protein levels by controlling stability of the PATJ/PALS-1 complex; upon MUPP-1 depletion, increased PATJ localizes at the migrating front and recruits more PAR3, indicating at least two distinct pools of PALS-1 complexes (PALS-1/MUPP-1 and PALS-1/PATJ) co-exist in epithelial cells. siRNA depletion, co-immunoprecipitation, immunofluorescence, western blotting in MCF10A cells Experimental cell research Medium 23880463
2010 CIPP (PATJ/INADL) forms a tripartite complex with IRSp53 and Cypin in neuronal cells; CIPP acts as a bridge linking the C-termini of IRSp53 and Cypin via its PDZ domains, and IRSp53 connects to Cypin via an SH3-mediated interaction requiring two positively charged Cypin residues; the three proteins co-localize at the tips of neuronal protrusions. Co-immunoprecipitation in cultured cells, domain mapping with PDZ domains, SH3-domain interaction mutagenesis, co-localization by immunofluorescence in neuronal cells Biological chemistry Medium 20707603
2009 CIPP (PATJ/INADL) PDZ2 directly binds IRSp53 C-terminus; co-transfection of CIPP with IRSp53 in mammalian cells induces reorganization of CIPP into large punctate multi-protein assemblies that are not cytoplasmic vesicles. GST pull-down with individual PDZ domains, co-transfection/co-localization, endocytic marker co-staining The Biochemical journal Medium 19138174
2023 PATJ knockout in epithelial cells causes tight junction defects, disturbed apical-basal polarity, and impaired lumen formation in 3D cysts; mechanistically, PATJ associates with and inhibits HDAC7, and HDAC7 inhibition/knockdown rescues the polarity and lumen phenotypes; PATJ-mediated regulation of HDAC7 controls expression of genes involved in cell junction assembly and membrane organization; this HDAC7-regulatory function is independent of Pals1 binding. CRISPR-Cas9 knockout, 3D cyst assay, co-immunoprecipitation (PATJ-HDAC7), HDAC7 inhibitor/siRNA rescue, RNA-seq gene expression analysis Cellular and molecular life sciences : CMLS High 37878054
2023 In mouse preimplantation embryos, PATJ and MPDZ together are required for blastocyst formation and trophectoderm lineage specification; double depletion disrupts the apical CRB and PAR polarity complexes, tight junctions, and actin filaments in outer cells, leading to ectopic Hippo signaling activation, reduced YAP nuclear localization, suppressed Cdx2 expression, and failure of trophectoderm differentiation. Zygote microinjection of RNAi constructs, immunofluorescence for polarity/junction markers, Hippo pathway readouts (YAP phosphorylation/localization), transcription factor expression analysis Reproduction (Cambridge, England) Medium 37318097
2021 CIPP (PATJ/INADL) interacts via its PDZ domains with the C-terminal PDZ-binding motif of the serotonin 5-HT2B receptor; co-expression of CIPP increases 5-HT2B receptor clustering at neuronal surfaces, prevents receptor dispersion after agonist stimulation, and potentiates inositol phosphate production and calcium mobilization; CIPP, 5-HT2B, and NMDA receptor NR1 subunit form a macromolecular complex. Peptide affinity chromatography/mass spectrometry, co-immunoprecipitation in COS-7 cells, IP measurement, calcium imaging, immunofluorescence in hippocampal neurons ACS chemical neuroscience Medium 33739808
2025 PATJ knockout in HEK293 cells alters YAP1 nuclear translocation, and PATJ deletion causes transcriptional reprogramming including dysregulation of vascular/stress-response genes (RUNX1, HEY1, NUPR1, HK2); in C. elegans, the PATJ homolog mpz-1 is upregulated under hypoxia and its knockdown causes abnormal neuronal morphology and increased mortality exacerbated by hypoxia. CRISPR-Cas9 knockout, YAP1 nuclear translocation assay, RNA-seq, C. elegans mpz-1 knockdown/hypoxia experiments Redox biology Medium 40472775
2025 PATJ conditional knockout in T cells impairs immunological synapse (IS) formation and T cell activation in vitro and in vivo; PATJ expression increases rapidly upon T cell activation; a specific minimal PDZ domain combination within PATJ is sufficient to support TCR signaling and, when engineered into a CAR construct, enhances CAR-T cell cytotoxicity against solid tumors. Conditional T cell-specific Patj knockout mice, confocal microscopy of IS formation, in vitro/in vivo T cell activation assays, PATJ truncation domain mapping, CAR-T cell cytotoxicity assay Journal for immunotherapy of cancer Medium 40341028
2025 PatJ (PATJ) is required for lumen initiation in MDCK-II cells; PatJ controls the architecture of the apical-lateral border and connects the tight junction to the apical cortex, and its loss impairs fusion of vacuolar apical compartments (VACs) at the apical membrane initiation site (AMIS) to generate a nascent lumen. Quantitative light and electron microscopy, proximity proteomics (BioID), loss-of-function experiments in MDCK-II cells, apical cargo trafficking assays bioRxivpreprint Medium
2025 PATJ zebrafish knockout (via homozygous truncating PATJ variant c.830delC validated in patient and zebrafish model) produces a ciliopathy phenotype including polycystic kidney disease and hydrocephalus, demonstrating an essential role for PATJ in cilia formation and function. Massively parallel sequencing (patient), zebrafish in vivo loss-of-function validation, ciliopathy phenotype characterization HGG advances Medium 40931526

Source papers

Stage 0 corpus · 38 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2005 PATJ regulates tight junction formation and polarity in mammalian epithelial cells. The Journal of cell biology 162 15738264
2002 hINADl/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells. The Journal of biological chemistry 141 11964389
2008 The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells. Blood 115 18824598
2005 PATJ connects and stabilizes apical and lateral components of tight junctions in human intestinal cells. Journal of cell science 115 16129888
1998 CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins. Molecular and cellular neurosciences 92 9647694
2009 Nephrocystin-1 and nephrocystin-4 are required for epithelial morphogenesis and associate with PALS1/PATJ and Par6. Human molecular genetics 89 19755384
2007 Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties. Genes to cells : devoted to molecular & cellular mechanisms 81 17397395
2007 PATJ regulates directional migration of mammalian epithelial cells. EMBO reports 70 17235357
2007 PATJ, a tight junction-associated PDZ protein, is a novel degradation target of high-risk human papillomavirus E6 and the alternatively spliced isoform 18 E6. Journal of virology 70 17287269
2002 The multivalent PDZ domain-containing protein CIPP is a partner of acid-sensing ion channel 3 in sensory neurons. The Journal of biological chemistry 65 11872753
2009 Similar and distinct properties of MUPP1 and Patj, two homologous PDZ domain-containing tight-junction proteins. Molecular and cellular biology 64 19255144
2019 PATJ Low Frequency Variants Are Associated With Worse Ischemic Stroke Functional Outcome. Circulation research 55 30582445
2001 Distinct binding specificity of the multiple PDZ domains of INADL, a human protein with homology to INAD from Drosophila melanogaster. The Journal of biological chemistry 55 11509564
2003 The Drosophila cell survival gene discs lost encodes a cytoplasmic Codanin-1-like protein, not a homolog of tight junction PDZ protein Patj. Developmental cell 50 14667407
2012 Drosophila PATJ supports adherens junction stability by modulating Myosin light chain activity. The Journal of cell biology 32 23128243
2013 The multi-PDZ domain protein-1 (MUPP-1) expression regulates cellular levels of the PALS-1/PATJ polarity complex. Experimental cell research 28 23880463
2005 A unified assembly mode revealed by the structures of tetrameric L27 domain complexes formed by mLin-2/mLin-7 and Patj/Pals1 scaffold proteins. Proceedings of the National Academy of Sciences of the United States of America 25 15863617
2012 Tissue-specific function of Patj in regulating the Crumbs complex and epithelial polarity. Development (Cambridge, England) 20 23136386
2006 Rapid flow cytometric measurement of cytokine-induced phosphorylation pathways [CIPP] in human peripheral blood leukocytes. Clinical immunology (Orlando, Fla.) 19 16959540
2012 Drosophila Patj plays a supporting role in apical-basal polarity but is essential for viability. Development (Cambridge, England) 17 22791898
2012 Structure of an L27 domain heterotrimer from cell polarity complex Patj/Pals1/Mals2 reveals mutually independent L27 domain assembly mode. The Journal of biological chemistry 15 22337881
2006 Successful simultaneous measurement of cell membrane and cytokine induced phosphorylation pathways [CIPP] in human peripheral blood mononuclear cells. Journal of immunological methods 11 16716344
2023 PATJ inhibits histone deacetylase 7 to control tight junction formation and cell polarity. Cellular and molecular life sciences : CMLS 8 37878054
2022 MUC1 and Polarity Markers INADL and SCRIB Identify Salivary Ductal Cells. Journal of dental research 8 35259994
2021 Research Progress on PATJ and Underlying Mechanisms Associated with Functional Outcomes After Stroke. Neuropsychiatric disease and treatment 6 34471355
2010 The neuronal proteins CIPP, Cypin and IRSp53 form a tripartite complex mediated by PDZ and SH3 domains. Biological chemistry 6 20707603
2009 Channel-interacting PDZ protein, 'CIPP', interacts with proteins involved in cytoskeletal dynamics. The Biochemical journal 6 19138174
2024 The CIpP activator, TR-57, is highly effective as a single agent and in combination with venetoclax against CLL cells in vitro. Leukemia & lymphoma 5 38227293
2021 Serotonin 2B Receptor by Interacting with NMDA Receptor and CIPP Protein Complex May Control Structural Plasticity at Glutamatergic Synapses. ACS chemical neuroscience 5 33739808
2025 PATJ regulates cell stress responses and vascular remodeling post-stroke. Redox biology 4 40472775
2024 Isolation and Characterization of a Lytic Phage PaTJ Against Pseudomonas aeruginosa. Viruses 3 39772127
2023 PATJ and MPDZ are required for trophectoderm lineage specification in early mouse embryos. Reproduction (Cambridge, England) 2 37318097
2025 PDZ domains of PATJ facilitate immunological synapse formation to promote T cell activation. Journal for immunotherapy of cancer 1 40341028
2011 Crystallization and preliminary X-ray data collection of the L27(PATJ)-(L27N,L27C)(Pals1)-L27(MALS) tripartite complex. Acta crystallographica. Section F, Structural biology and crystallization communications 1 22102253
2026 Reforming the cellular, molecular, and genetics course in a graduate biomedical science program: CIPP guided course evaluation. Pakistan journal of medical sciences 0 42257084
2025 PATJ deficiency leads to cystic kidney disease and related ciliopathies. HGG advances 0 40931526
2025 SIPA1L3 via its PDZ domain inhibits the tight junction-associated AMOT-Patj to promote a malignant phenotype in NSCLC. Medicine 0 41088697
2025 Nano Ag-AlOOH modified cured-in-place-pipe (CIPP) composites for controlling sewer biofilm:performance and mechanism of extracellular polymeric substances reduction and antimicrobial activity. Environmental research 0 41422896

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