Affinage

HDAC7

Histone deacetylase 7 · UniProt Q8WUI4

Length
952 aa
Mass
102.9 kDa
Annotated
2026-04-28
100 papers in source corpus 43 papers cited in narrative 43 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

HDAC7 is a class IIa histone deacetylase that functions primarily as a signal-responsive transcriptional corepressor whose activity is governed by regulated nucleocytoplasmic shuttling, and which exerts both deacetylase-dependent and deacetylase-independent effects on gene expression, immune cell differentiation, metabolism, and vascular biology. In the nucleus, HDAC7 represses transcription by binding MEF2 family transcription factors via its N-terminal domain and recruiting the SMRT/NCoR–HDAC3 complex, which provides the principal deacetylase activity; PKD1-mediated phosphorylation (Ser155/318/448 in thymocytes; Ser178/344/479 in endothelial cells) triggers 14-3-3-dependent nuclear export, while PP1β/MYPT1 and PP2A-Bα dephosphorylation restores nuclear localization, coupling extracellular signals—TCR engagement, VEGF, TLR4 agonists—to derepression of target genes such as Nur77, MMP10, and IL-1β (PMID:12753745, PMID:15623513, PMID:17369396, PMID:18617643, PMID:23955003, PMID:34811804). Beyond chromatin-level repression, HDAC7 deacetylates non-histone substrates including STAT3, β-catenin (Lys49), TFEB (K310), PINK1, and FOXP1, linking it to JAK-STAT signaling, Wnt pathway modulation, lysosomal biogenesis, mitophagy, and stem-cell self-renewal (PMID:29126425, PMID:35277183, PMID:39806423, PMID:41286926, PMID:37507770). HDAC7 also performs deacetylase-independent scaffolding functions—interacting with TRAF6–TAK1 to activate NF-κB/MAPK signaling and directing macrophage metabolic reprogramming toward glycolysis or the pentose phosphate pathway—and its protein stability is regulated by USP10 deubiquitination, TRIM28-mediated sumoylation, SIK1 phosphorylation, and CBX4/proteasome-dependent degradation (PMID:39049738, PMID:36649417, PMID:35277183, PMID:39629136, PMID:32106109, PMID:28283560).

Mechanistic history

Synthesis pass · year-by-year structured walk · 16 steps
  1. 2001 High

    Establishing that HDAC7 is a MEF2-binding transcriptional corepressor whose nuclear deacetylase activity depends on HDAC3 resolved the paradox of a class II HDAC with intrinsically weak catalytic function and identified the SMRT/NCoR–HDAC3 axis as the operative enzymatic mechanism.

    Evidence Co-immunoprecipitation, GST pulldown, deletion mutagenesis, reporter and deacetylase activity assays in mammalian cells

    PMID:11279209 PMID:11466315

    Open questions at the time
    • Structural basis of MEF2–HDAC7 N-terminal interaction not resolved
    • Whether HDAC7's own catalytic domain contributes to repression in vivo remained ambiguous
  2. 2003 High

    Demonstrating that TCR-induced phosphorylation at three serines (S155/S318/S448) drives HDAC7 nuclear export and Nur77 derepression in thymocytes established signal-regulated nucleocytoplasmic shuttling as the primary mechanism controlling HDAC7 corepressor activity in T-cell selection.

    Evidence Triple serine-to-alanine mutagenesis, nuclear export assays, RNAi, and reporter assays in CD4+CD8+ thymocytes

    PMID:12753745

    Open questions at the time
    • Identity of the kinase was unknown at this stage
    • Whether the same mechanism operates in other cell types was untested
  3. 2004 High

    Identification of PKD1 as the kinase that phosphorylates HDAC7 at S155/S318/S448 downstream of TCR signaling closed the gap between receptor engagement and HDAC7 export, placing PKD1 as the central regulatory kinase.

    Evidence In vitro kinase assay, dominant-negative PKD1, phospho-specific mutagenesis in thymocytes

    PMID:15623513

    Open questions at the time
    • Whether additional kinases contribute in non-lymphoid contexts was unresolved
    • Mitochondrial localization of HDAC7 reported in prostate cells (PMID:15364908) was not integrated with the shuttling model
  4. 2007 High

    Discovery that the PP1β/MYPT1 myosin phosphatase dephosphorylates HDAC7 and promotes its nuclear retention completed the bidirectional regulatory circuit controlling HDAC7 localization and Nur77 repression in thymocytes.

    Evidence Co-immunoprecipitation, phosphatase activity assays, Nur77 reporter assays in thymocytes

    PMID:17369396

    Open questions at the time
    • Whether PP2A also contributes (later shown in endothelial cells) was unknown
    • Quantitative dynamics of phosphorylation/dephosphorylation cycling not measured
  5. 2008 High

    Crystal structures of the HDAC7 catalytic domain revealed a class IIa-specific zinc-binding motif and enlarged active site that explain its low intrinsic deacetylase activity, providing a structural rationale for HDAC7's predominant role as a scaffolding corepressor rather than a potent enzyme.

    Evidence X-ray crystallography with hydroxamate inhibitor co-crystals and in vitro deacetylase assay

    PMID:18285338

    Open questions at the time
    • No structure of full-length HDAC7 or HDAC7–MEF2–NCoR complex
    • How the catalytic domain contributes to non-histone substrate deacetylation was unaddressed
  6. 2008 High

    Extension of the PKD1-HDAC7 shuttling mechanism to endothelial cells downstream of VEGF, where HDAC7 export derepresses MMP10 and MT1-MMP to drive angiogenesis, demonstrated that the same regulatory logic operates in vascular biology with distinct target genes.

    Evidence siRNA, dominant-negative mutants, pharmacological inhibitors, angiogenesis assays in HUVECs and sprouting models

    PMID:18617643

    Open questions at the time
    • Direct chromatin occupancy at MMP loci not shown in this study
    • Relative contributions of enzymatic versus scaffolding functions in endothelial cells unclear
  7. 2010 Medium

    Reports that HDAC7 protects neurons by repressing c-jun independently of its catalytic domain, and that nuclear HDAC7 inhibits myogenesis partly through MEF2 binding, reinforced the concept of deacetylase-independent transcriptional repression as a general HDAC7 function across cell types.

    Evidence ChIP, catalytic-dead mutants, shRNA, differentiation and cell death assays in neurons and C2C12 myocytes

    PMID:20621129 PMID:21118817

    Open questions at the time
    • Mechanism of catalytic-domain-independent repression (histone modification-independent?) not molecularly defined
    • Single-lab findings for the neuronal context
  8. 2012 High

    Conditional HDAC7 knockout in osteoclast lineage cells revealed a non-redundant in vivo role for HDAC7 in suppressing β-catenin and NFATc1 activity to restrain bone resorption, establishing HDAC7's physiological importance in skeletal homeostasis.

    Evidence Co-immunoprecipitation, conditional knockout mouse, osteoclastogenesis assays, reporter assays

    PMID:23204328

    Open questions at the time
    • Whether HDAC7 directly deacetylates β-catenin in osteoclasts was not tested at this point
    • Redundancy with HDAC4/5 in bone not fully assessed
  9. 2013 High

    Two studies established HDAC7 as a lineage fidelity factor: PP2A-Bα/HDAC7 maintains vascular lumen stability via ArgBP2/RhoA suppression, and HDAC7 binds MEF2C in pre-B cells to repress myeloid gene programs, preventing inappropriate lineage transdifferentiation.

    Evidence Zebrafish genetics and epistasis (endothelial), Co-IP plus ChIP plus functional macrophage assays (B-cell/macrophage transdifferentiation)

    PMID:23696748 PMID:23955003

    Open questions at the time
    • Whether HDAC7 represses the same gene sets in human B-cell progenitors not confirmed
    • Mechanism by which PP2A-Bα controls HDAC7 activity distinct from PP1β/MYPT1 not fully resolved
  10. 2016 High

    Conditional knockout of HDAC7 in B-cell progenitors caused a dramatic block at the pro-B stage with derepression of myeloid and T-cell genes, confirming HDAC7 as essential for B-lineage commitment through genome-wide MEF2C-dependent epigenetic silencing.

    Evidence Conditional knockout mouse, ChIP-seq, flow cytometry, Co-IP

    PMID:27810920

    Open questions at the time
    • Functional redundancy with HDAC5 in later B-cell stages not excluded
    • Whether HDAC7 loss permits actual lineage conversion in vivo not tested
  11. 2017 High

    Identification of STAT3 as a direct deacetylation substrate of HDAC7, where HDAC7 loss enhances STAT3 acetylation and phosphorylation driving lung tumorigenesis, expanded HDAC7's substrate repertoire beyond histones and established a tumor-suppressive mechanism in lung.

    Evidence Co-IP, pulldown, epistasis with dnSTAT3, Hdac7+/−/K-Ras mouse model

    PMID:29126425

    Open questions at the time
    • Whether HDAC7 or the HDAC7-recruited HDAC3 performs the actual deacetylation not biochemically dissected
    • Tissue specificity of HDAC7-STAT3 axis unexplored
  12. 2020 High

    Discovery that SIK1 phosphorylates and stabilizes HDAC7 protein during cardiac stress, with HDAC7 acting as a pro-hypertrophic effector inducing c-Myc, revealed a context where HDAC7 functions as a transcriptional activator rather than repressor, complicating the canonical model.

    Evidence In vitro kinase assay, cardiac-specific gain/loss-of-function, rodent heart failure models, human iPSC-derived cardiomyocytes

    PMID:32106109

    Open questions at the time
    • Mechanism of transcriptional activation (co-activator recruitment?) not identified
    • Whether SIK1 phosphorylation alters HDAC7 subcellular localization in cardiomyocytes unclear
  13. 2021 High

    Dissection of enzymatic versus scaffolding functions in macrophages showed that HDAC7's deacetylase activity supports IL-1β production while its non-enzymatic scaffolding drives glycolytic reprogramming, establishing HDAC7 as a dual-function metabolic regulator in innate immunity.

    Evidence Hdac7-KO macrophages reconstituted with wild-type vs enzyme-dead mutant, extracellular acidification rate, cytokine measurement

    PMID:34811804

    Open questions at the time
    • Specific scaffolding partners mediating glycolysis not identified in this study
    • Whether enzyme-dead HDAC7 retains acetyllysine reader function contributing to this phenotype not tested
  14. 2022 High

    Multiple discoveries in 2022 revealed new layers of HDAC7 regulation and function: CBX4-mediated ubiquitin-dependent degradation controls Nur77 derepression in memory formation; HDAC7 deacetylates β-catenin at Lys49 and is stabilized by USP10; HDAC7 functions as an acetyllysine reader via NCoR dissociation; and an HDAC7 R166H variant enhances Treg function and protects against autoimmune disease.

    Evidence Co-IP/ubiquitination assays, fear conditioning (CBX4); acetylation/phosphorylation blots, xenograft (β-catenin/USP10); in vitro acetyllysine peptide assay (reader); conditional KO and knock-in mice with EAE model and scRNA-seq (Treg)

    PMID:28283560 PMID:35277183 PMID:35709754 PMID:36516268

    Open questions at the time
    • Structural basis of acetyllysine reading by the HDAC7 catalytic domain not resolved
    • Whether USP10-HDAC7 interaction is direct or complex-mediated unclear
    • HDAC7 R166H mechanism of enhanced Treg function at the molecular level not fully defined
  15. 2023 High

    Metabolic flux analysis in HDAC7-deficient macrophages revealed that HDAC7 directs a metabolic switch between glycolysis and the pentose phosphate pathway via 6PGD, generating NADPH/RL5P for antimicrobial ROS production, establishing HDAC7 as a central node in innate immune metabolic reprogramming.

    Evidence Hdac7-KO macrophages, metabolic flux analysis, uropathogenic E. coli infection models, 6PGD and RL5P functional assays

    PMID:36649417

    Open questions at the time
    • Direct mechanism by which HDAC7 controls 6PGD expression or activity not identified
    • Whether the metabolic switch is deacetylase-dependent or scaffolding-dependent not resolved
  16. 2024 High

    A series of 2024 studies extended HDAC7's non-histone substrate repertoire to TFEB (K310 deacetylation inhibiting lysosomal biogenesis and tau clearance) and PINK1 (deacetylation suppressing mitophagy), established its deacetylase-independent scaffolding of the TRAF6–TAK1 complex for NF-κB/MAPK signaling using PROTAC-based degradation, and identified HDAC7 interaction with HIRA/H3.3 governing replication fork dynamics and heterochromatin.

    Evidence MS-identified deacetylation sites, PROTAC degrader, Co-IP, ChIP-seq, PS19 tau transgenic mice, single-molecule DNA fiber assays

    PMID:38657041 PMID:39049738 PMID:39806423 PMID:40967435 PMID:41286926

    Open questions at the time
    • Whether HDAC7 or recruited HDAC3 mediates TFEB and PINK1 deacetylation not fully resolved
    • PROTAC degradation could affect scaffolding and enzymatic functions simultaneously
    • H3.3–HIRA–HDAC7 interaction mechanism (direct or bridged) not determined

Open questions

Synthesis pass · forward-looking unresolved questions
  • A unified structural and dynamic model integrating HDAC7's enzymatic, scaffolding, and acetyllysine-reading functions across cell types is lacking, and the relative in vivo contributions of each modality to specific phenotypes remain unresolved.
  • No full-length HDAC7 structure or HDAC7–NCoR–HDAC3 complex structure exists
  • Systematic identification of direct deacetylation substrates versus HDAC3-mediated substrates not performed
  • How HDAC7 switches between activator and repressor modes in different cell contexts is mechanistically undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 7 GO:0140110 transcription regulator activity 6 GO:0042393 histone binding 3 GO:0060090 molecular adaptor activity 2
Localization
GO:0005634 nucleus 5 GO:0005829 cytosol 3 GO:0005694 chromosome 2 GO:0005739 mitochondrion 1
Pathway
R-HSA-168256 Immune System 6 R-HSA-162582 Signal Transduction 5 R-HSA-4839726 Chromatin organization 4 R-HSA-74160 Gene expression (Transcription) 4 R-HSA-1266738 Developmental Biology 3 R-HSA-5357801 Programmed Cell Death 3 R-HSA-1430728 Metabolism 2 R-HSA-9612973 Autophagy 2
Partners
CTNNB1HDAC3HIRAMEF2CMEF2DNCOR1PRKCMSTAT3
Complex memberships
MEF2-HDAC7 repressor complexSMRT/NCoR-HDAC3 corepressor complexTRAF6-TAK1 signaling complex

Evidence

Reading pass · 43 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2008 Crystal structures of human HDAC7 catalytic domain and its complexes with two hydroxamate inhibitors revealed a class IIa-specific zinc binding motif adjacent to the active site and an enlarged active site pocket distinct from class I and IIb HDACs; cdHDAC7 possesses low but measurable deacetylase activity inhibitable by known HDAC inhibitors. X-ray crystallography, in vitro deacetylase activity assay, HDAC inhibitor treatment The Journal of biological chemistry High 18285338
2001 HDAC7 deacetylase activity in the nucleus depends on its interaction with class I HDAC3; cytoplasmic HDAC7 not bound to HDAC3 is enzymatically inactive; SMRT and N-CoR corepressors serve as bridging mediators between HDAC7 and HDAC3 via two distinct repressor domains. Co-immunoprecipitation, HDAC activity assay, subcellular fractionation, functional reporter assays The Journal of biological chemistry High 11466315
2001 HDAC7 directly interacts with MEF2 proteins (MEF2-A, -C, -D) via its N-terminal 121 amino acids (repression domain 1), and the MADS domain of MEF2 mediates this interaction; HDAC7 represses MEF2 transcriptional activity independently of its C-terminal deacetylase domain; HDAC7 also interacts with CtBP and other class I/II HDACs; upon muscle differentiation induction, HDAC7 translocates from nucleus to cytoplasm. GST pulldown, co-immunoprecipitation, reporter assays, deletion mutagenesis, live-cell imaging/fractionation The Journal of biological chemistry High 11279209
2003 HDAC7 inhibits Nur77 expression via the transcription factor MEF2D in CD4+CD8+ thymocytes; TCR activation induces nuclear export of HDAC7, derepressing Nur77 and triggering apoptosis; a triple serine mutant (S155A/S318A/S448A) blocks TCR-induced nuclear export and suppresses TCR-mediated apoptosis; HDAC7-VP16 fusion activates Nur77; RNAi knockdown of HDAC7 increases apoptosis. Site-directed mutagenesis, nuclear export assays, reporter assays, RNAi knockdown, overexpression studies in thymocytes Immunity High 12753745
2004 Protein kinase D1 (PKD1) is activated after TCR engagement, physically interacts with HDAC7, and phosphorylates Ser155, Ser318, and Ser448 on HDAC7, causing its nuclear export via a calcium-independent pathway; kinase-inactive PKD1 blocks HDAC7 nuclear export; PKD1-mediated HDAC7 export leads to Nur77 transcriptional activation via MEF2 binding sites. Co-immunoprecipitation, in vitro kinase assay, phospho-specific mutagenesis, dominant-negative PKD1 overexpression, nuclear export assays The Journal of biological chemistry High 15623513
2004 HDAC7 localizes to the mitochondrial inner membrane space in prostate epithelial cells and undergoes cytoplasmic relocalization upon initiation of apoptosis. Subcellular fractionation, mitochondrial isolation, immunofluorescence, apoptosis induction The Journal of biological chemistry Medium 15364908
2006 HDAC7 acts as a corepressor of the androgen receptor (AR); hormone-occupied AR induces nuclear transfer of HDAC7; nuclear colocalization pattern depends on ligand type; HDAC7 repression of AR is partially deacetylase-independent; PML-3 sequesters HDAC7 and relieves AR repression. Subcellular localization assays, reporter gene assays, dominant-negative and deletion mutant analysis Experimental cell research Medium 16860317
2007 Myosin phosphatase complex components PP1β and MYPT1 interact with HDAC7 in thymocytes; myosin phosphatase dephosphorylates HDAC7 and promotes its nuclear localization, leading to repression of Nur77 and inhibition of apoptosis in CD4+CD8+ thymocytes. Co-immunoprecipitation, phosphatase activity assays, nuclear localization assays, Nur77 reporter assays Genes & development High 17369396
2008 VEGF stimulates PKD1-dependent phosphorylation of HDAC7 at Ser178, Ser344, and Ser479, causing its cytoplasmic accumulation in endothelial cells; this leads to upregulation of angiogenic genes MT1-MMP and MMP10; a PKD1 phosphorylation-deficient HDAC7 mutant blocks VEGF-induced angiogenic gene expression, EC migration, tube formation, and microvessel sprouting. Pharmacological inhibitors (PLC-γ/PKC/PKD1 pathway), siRNA, adenoviral dominant-negative mutants, phospho-specific antibodies, angiogenesis assays Arteriosclerosis, thrombosis, and vascular biology High 18617643
2009 HDAC7 undergoes alternative splicing during embryonic stem cell differentiation into smooth muscle cells; PDGF promotes HDAC7 splicing; HDAC7 splicing modulates the SRF-myocardin complex to drive SMC differentiation. Western blot, immunofluorescence, overexpression in ES cells, SMC differentiation assays, transgenic mouse ex vivo culture Journal of cell science Medium 19174469
2010 HDAC7 protects neurons from apoptosis by directly associating with the c-jun gene promoter and suppressing c-jun expression; neuroprotection does not require its catalytic domain and is insensitive to HDAC inhibitors. Chromatin immunoprecipitation, shRNA knockdown, forced expression, catalytic domain mutants, neuronal cell death assays The Journal of biological chemistry Medium 21118817
2010 Sp1 transcription factor binds to a PDGF-BB-responsive element (−343 to −292 bp) in the HDAC7 promoter and transcriptionally activates HDAC7 expression during SMC differentiation from ES cells; HDAC7 is required downstream of Sp1 for SMC differentiation gene expression. Promoter deletion analysis, luciferase reporter assays, ChIP, Sp1 knockdown and overexpression, ES cell differentiation assays The Journal of biological chemistry Medium 20889501
2010 Nuclear-retained HDAC7 inhibits myocyte differentiation and migration in C2C12 cells; this inhibition is partially relieved by disrupting HDAC7:MEF2 interaction; phospho-HDAC7 (pS178) co-localizes with actin filaments in myocytes; cytoplasmic retention of HDAC7 is required for normal myogenesis. Stable expression of HDAC7 mutants, immunofluorescence, phalloidin co-staining, migration assays, differentiation assays Biochimica et biophysica acta Medium 20621129
2011 HDAC7 interacts with the transcription factor Mitf in RAW264 cells and osteoclasts; HDAC7 represses Mitf transcriptional activity; suppression of HDAC7 accelerates osteoclast differentiation whereas suppression of HDAC3 inhibits it; HDAC7 repression of Mitf is TSA-insensitive (deacetylation-independent). Co-immunoprecipitation, reporter assays, siRNA knockdown, trichostatin A treatment, osteoclast differentiation assays The Journal of biological chemistry Medium 21324898
2012 HDAC7 interacts with β-catenin in chondrocytes and suppresses β-catenin transcriptional activity and cyclin D1 expression; upon osteoclast stimulation by RANKL, HDAC7 suppresses NFATc1 and prevents β-catenin downregulation; conditional HDAC7 knockout in the osteoclast lineage reduces bone mass due to elevated bone resorption. Co-immunoprecipitation, conditional knockout mouse model, in vitro osteoclastogenesis assays, reporter assays Molecular endocrinology High 23204328
2012 HDAC7 epigenetically represses AKAP12 in endothelial cells by deacetylating H3 histones at the AKAP12 promoter; HDAC7 depletion increases H3 acetylation at the AKAP12 promoter, upregulates AKAP12, which then activates STAT3 via PKC phosphorylation, inhibiting EC migration and tube formation. siRNA knockdown, proteomic analysis, ChIP, HUVEC migration and tube formation assays Angiogenesis Medium 22584896
2013 PP2A-Bα regulatory subunit controls HDAC7 activity; loss of PP2A-Bα abrogates HDAC7 transcriptional repression, leading to ArgBP2 expression, RhoA hyperactivation, and vascular lumen instability; the PP2A-Bα/HDAC7/ArgBP2 axis maintains endothelial cytoskeletal dynamics. Zebrafish vascular lumen assay, siRNA in ECs, epistasis experiments, cytoskeletal and ECM adhesion assays The EMBO journal High 23955003
2013 HDAC7 interacts with MEF2C in pre-B cells and is recruited to MEF2 binding sites at promoters of myeloid-specific genes to repress them; HDAC7 downregulation is required for transdifferentiation of pre-B cells into macrophages; re-expression of HDAC7 blocks induction of macrophage-specific genes and suppresses phagocytosis and cytokine responses. Co-immunoprecipitation, chromatin immunoprecipitation, microarray, functional macrophage assays (phagocytosis, LPS response) PLoS genetics High 23696748
2014 Hdac7 binds β-catenin in proliferating chondrocytes and suppresses β-catenin levels and transcriptional activity; upon stimulation of chondrocyte maturation, Hdac7 translocates to the cytoplasm where it is degraded by the proteasome, releasing β-catenin to the nucleus; postnatal tissue-specific Hdac7 deletion expands the proliferative zone. Co-immunoprecipitation, conditional knockout mouse (tamoxifen-inducible Col2a1-Cre), primary chondrocyte adenoviral-Cre deletion, proteasome inhibition assays The Journal of biological chemistry High 25389289
2014 HDAC7 deacetylates HSP70 at K246; deacetylation of HSP70 by HDAC1 and HDAC7 promotes cancer cell survival and therapy resistance by inhibiting autophagic cell death; miR-34a targets HDAC1 and HDAC7 to restore autophagic cell death. miRNA target validation, knockdown/overexpression assays, cell survival/apoptosis assays, autophagy assays Cancer letters Medium 25173798
2015 Ectopically expressed HDAC7 localizes to the nucleus, interacts with MEF2C and corepressors HDAC3 and SMRT; both the HDAC7-MEF2C interaction domain and its catalytic domain are required for reduced cell viability in B-cell malignancies; HDAC7 induces apoptosis and downregulates c-Myc in pro-B-ALL and Burkitt lymphoma. Co-immunoprecipitation, domain deletion mutagenesis, xenograft model, apoptosis assays Cell death & disease Medium 25675295
2016 Conditional knockout of HDAC7 in B cell progenitors dramatically blocks early B cell development at the pro-B stage; HDAC7 represses myeloid and T lymphocyte genes in B cell progenitors through interaction with MEF2C; HDAC7 is recruited to promoters and enhancers of target genes and its absence increases histone active marks at these sites. Conditional knockout mouse model, ChIP-seq, ChIP, Co-immunoprecipitation, flow cytometry The Journal of experimental medicine High 27810920
2017 HDAC7 directly interacts with and deacetylates STAT3, thereby suppressing STAT3 tyrosine phosphorylation and activation; HDAC7 mutation in lung tumors or depletion in human lung cancer cells results in enhanced STAT3 acetylation and phosphorylation; dnStat3 reverses the tumor-suppressive effects of HDAC7 loss. Co-immunoprecipitation, pull-down assay, Western blot for acetylation/phosphorylation, genetic rescue with dnStat3, Hdac7+/-/K-Ras mouse model Molecular cancer High 29126425
2017 Tonic LAT-mediated TCR signals constitutively export HDAC7 from the nucleus of naive CD4+ T cells; without LAT, HDAC7 remains nuclear and represses Nur77 and Irf4; Nur77 suppresses CD4+ T cell proliferation, and Irf4 suppresses TH2 polarization. LAT-deficient mouse model, nuclear export assays, genetic knockout epistasis, transcriptomic analysis Cell reports Medium 28538176
2017 CBX4 E3 ligase ubiquitinates HDAC7, promoting its ubiquitin-dependent proteasomal degradation in the hippocampus following contextual fear conditioning; HDAC7 degradation leads to derepression of Nur77, which is required for long-term fear memory formation. Co-immunoprecipitation, ubiquitination assay, in vivo fear conditioning, shRNA knockdown, Western blot The Journal of neuroscience Medium 28283560
2019 HDAC7 binds near transcription start sites and super-enhancers of oncogenes (c-MYC, CD44, CDKN1B, SLUG, VEGFA, XBP1) in breast cancer stem cells and contributes to H3K27 acetylation and transcriptional activity at these loci; HDAC1/HDAC3 inhibition leads to HDAC7 downregulation and decreased H3K27ac at these sites. ChIP-seq, siRNA knockdown, gene expression analysis in matched stem/non-stem tumor cell models Oncogene Medium 31375747
2020 SIK1 phosphorylates and stabilizes HDAC7 protein during cardiac stress; gain- and loss-of-function of HDAC7 in cardiomyocytes shows it acts as a prohypertrophic effector inducing c-Myc expression; this contrasts with the canonical MEF2 corepressor function of class IIa HDACs. In vitro kinase assay, cardiac-specific overexpression/knockdown, rodent heart failure models, human iPSC-derived cardiomyocytes The Journal of clinical investigation High 32106109
2021 TLR4 agonist LPS rapidly increases class IIa HDAC enzymatic activity in macrophages in a MyD88-dependent manner (except TLR3); Hdac7 is required for this activation; Hdac7 enzymatic activity supports IL-1β and Ccl2 production, while its non-enzymatic scaffolding function supports glycolysis reprogramming in response to submaximal LPS. Hdac7-knockout macrophages, reconstitution with wild-type vs enzyme-dead Hdac7, extracellular acidification rate, cytokine measurement Journal of leukocyte biology High 34811804
2021 TGF-β signaling in concert with HDAC7 suppresses TCA cycle enzyme expression in renal cell carcinoma by repressing PGC-1α; pharmacological inhibition of TGF-β restores TCA cycle enzyme expression and suppresses tumor growth in an orthotopic RCC model. Proteomic analysis, gene expression profiling, PGC-1α re-expression, TGF-β inhibition in orthotopic mouse model JCI insight Medium 34609963
2022 HDAC7 deacetylates β-catenin at Lys49, reducing its phosphorylation at Ser45, thereby facilitating its nuclear translocation and activation of FGF18 via TCF4 binding; USP10 deubiquitinase interacts with and stabilizes HDAC7 protein. Co-immunoprecipitation, acetylation/phosphorylation Western blot, nuclear fractionation, USP10 knockdown/overexpression, lentiviral knockdown in xenograft models Journal of experimental & clinical cancer research Medium 35277183
2022 HDAC7 activates IKK by promoting deacetylation of IKKα and IKKβ, leading to NF-κB activation and pro-inflammatory gene expression in astrocytes; astrocyte-specific HDAC7 overexpression induces NF-κB activation and anxiety-like behaviors in mice. Co-immunoprecipitation, astrocyte-specific viral overexpression, IKK activity assays, behavioral testing, pharmacological HDAC7 inhibition Molecular neurobiology Medium 35871708
2022 HDAC7 acts as an epigenetic 'reader' of acetyllysine: class IIa HDAC4, -5, and -7 dissociate from corepressor NCoR in the presence of acetyllysine-containing peptides; mutation of an AR acetylation site regulates AR transcriptional activation through HDAC7-NCoR-HDAC3 dissociation. In vitro acetyllysine peptide binding assay, NCoR dissociation assay, site-directed mutagenesis of AR acetylation sites, reporter assays Cell chemical biology Medium 35709754
2022 HDAC7 R166H protective variant (rs148755202) enhances Treg suppressive capacity; Treg-specific conditional hemizygous HDAC7 deletion worsens EAE severity; knock-in mice bearing the orthologous R150H substitution show decreased EAE severity; HDAC7 regulates genes essential for Foxp3+ Treg function. Conditional knockout mouse, knock-in mouse model, single-cell RNA-seq of brain-infiltrating Tregs, in vitro Treg suppression assay, EAE model Science translational medicine High 36516268
2022 HDAC7 deacetylates FOXP1 in mesenchymal stem cells; HDAC7 and FOXP1 cooperatively sustain bone marrow MSC self-renewal and attenuate cellular senescence; acetylation of FOXP1 at T172 (murine) / T176 (human) is a critical modification controlling MSC proliferative capacity. Mass spectrometry identification of acetylation sites, single/double knockout mice, hESC-derived MSC gene engineering, self-renewal assays Stem cell research & therapy Medium 37507770
2022 HDAC7 absence in pro-B cells induces TET2 expression, which promotes global DNA 5-hydroxymethylation and chromatin decondensation; HDAC7 deficiency also causes aberrant expression of microRNAs and LINE-1 transposable elements. Conditional knockout pro-B cells, TET2 expression analysis, 5-hmC profiling, LINE-1 assays, ChIP-seq Nucleic acids research Medium 35904805
2023 HDAC7 in macrophages functions as a metabolic switch: LPS triggers HDAC7-dependent glycolysis and IL-1β production; bacterial signals trigger HDAC7-dependent pentose phosphate pathway (PPP) activation via 6PGD, generating NADPH and RL5P for antimicrobial ROS production; RL5P both kills bacteria and suppresses inflammatory responses. Hdac7-deficient macrophages, metabolic flux analysis, uropathogenic E. coli infection models, 6PGD and RL5P functional assays Proceedings of the National Academy of Sciences of the United States of America High 36649417
2024 HDAC7 directly interacts with TRAF6-TAK1 complex, initiating downstream MAPK/NF-κB signaling cascade in TLR4 signaling in macrophages; this proinflammatory scaffolding function is deacetylase-independent, as revealed by PROTAC-mediated selective HDAC7 degradation. PROTAC degrader (compound B4), Co-immunoprecipitation, LPS-stimulated macrophage cytokine profiling, mouse model Advanced science High 39049738
2024 HDAC7 deacetylates TFEB at K310, preventing TFEB nuclear translocation and lysosomal biogenesis in astrocytes; HDAC7 inhibition restores TFEB acetylation and enhances astrocytic tau clearance; genetic or pharmacological HDAC7 inhibition improves tau pathology and cognition in PS19 mice. Mass spectrometry identification of TFEB acetylation site, immunoprecipitation, TFEB nuclear translocation assays, PS19 tau transgenic mouse model with AAV-shRNA and TMP195 treatment, lysosomal biogenesis assays Molecular neurodegeneration High 39806423
2024 HDAC7 deacetylates PINK1, suppressing Parkin phosphorylation at Ser65 and inhibiting mitophagy in astrocytes; HDAC7 interacts with PINK1 and its inhibition restores TOMM20/40 recruitment and mitochondrial ATP release. Co-immunoprecipitation, acetylation assays, astrocyte-specific HDAC7 overexpression/knockout (AAV and genetic), mitophagy assays, Parkin phosphorylation analysis, behavioral testing in LPS mouse model Journal of neuroinflammation Medium 41286926
2024 HDAC7 is sumoylated by TRIM28, which upregulates HDAC7 protein; HDAC7 mediates H3K27 deacetylation to suppress SOX8 expression; reduced SOX8 activates JUN transcriptional activity to induce LGALS3 secretion, promoting mesenchymal transition in glioblastoma and M2 macrophage polarization. Mass spectrometry, RNA immunoprecipitation, co-immunoprecipitation, ChIP for H3K27ac, single-cell and spatial transcriptomics, in vitro/in vivo gain/loss-of-function Theranostics Medium 39629136
2024 HDAC7 interacts with HIRA and histone H3.3 on chromatin; HDAC7 knockdown disrupts H3.3-HIRA interaction, increases H3.3-DAXX association and H3K9me3, causing heterochromatin spreading, replication fork acceleration, replication stress, and reduced BRCA2 expression in glioblastoma cells. Co-immunoprecipitation, ChIP-seq, siRNA knockdown, single-molecule DNA fiber analysis, RPA2 phosphorylation assay, gene expression analysis The Journal of biological chemistry Medium 40967435
2024 HDAC7 cooperates with Aiolos and Smrt/Ncor1-Hdac3 corepressors to repress IL-2 transcription in Th17 cells; HDAC7 interacts with Aiolos to suppress Th17 negative regulators; Hdac7 (together with Hdac4) is selectively induced during Th17 differentiation and is dispensable in other Th subsets. Co-immunoprecipitation, ChIP, Hdac7 conditional knockout in T cells, colitis mouse model, pharmacological Hdac4/7 inhibition Proceedings of the National Academy of Sciences of the United States of America High 38657041
2025 HDAC7 promotes BCAA catabolism gene suppression to elevate SNAIL1 expression via NOTCH signaling activation, promoting aggressive RCC phenotypes; HDAC7 promotes in vivo tumor progression in RCC. HDAC7 loss-of-function in RCC cells, gene expression profiling, NOTCH pathway inhibition, in vivo xenograft model Science advances Medium 40465706

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2008 Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity. The Journal of biological chemistry 223 18285338
2001 Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo. The Journal of biological chemistry 192 11466315
2003 HDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosis. Immunity 186 12753745
2001 A dynamic role for HDAC7 in MEF2-mediated muscle differentiation. The Journal of biological chemistry 176 11279209
2016 Identification of a cancer stem cell-specific function for the histone deacetylases, HDAC1 and HDAC7, in breast and ovarian cancer. Oncogene 126 27694895
2004 Protein kinase D1 phosphorylates HDAC7 and induces its nuclear export after T-cell receptor activation. The Journal of biological chemistry 117 15623513
2019 HDAC7 regulates histone 3 lysine 27 acetylation and transcriptional activity at super-enhancer-associated genes in breast cancer stem cells. Oncogene 100 31375747
2008 High histone deacetylase 7 (HDAC7) expression is significantly associated with adenocarcinomas of the pancreas. Annals of surgical oncology 91 18506539
2007 Histone deacetylase inhibitors selectively suppress expression of HDAC7. Molecular cancer therapeutics 89 17876049
2014 MiR-34a regulates therapy resistance by targeting HDAC1 and HDAC7 in breast cancer. Cancer letters 85 25173798
2008 VEGF stimulates HDAC7 phosphorylation and cytoplasmic accumulation modulating matrix metalloproteinase expression and angiogenesis. Arteriosclerosis, thrombosis, and vascular biology 81 18617643
2011 HDAC3 and HDAC7 have opposite effects on osteoclast differentiation. The Journal of biological chemistry 77 21324898
2007 Myosin phosphatase dephosphorylates HDAC7, controls its nucleocytoplasmic shuttling, and inhibits apoptosis in thymocytes. Genes & development 73 17369396
2010 Neuroprotection by histone deacetylase-7 (HDAC7) occurs by inhibition of c-jun expression through a deacetylase-independent mechanism. The Journal of biological chemistry 72 21118817
2009 Splicing of HDAC7 modulates the SRF-myocardin complex during stem-cell differentiation towards smooth muscle cells. Journal of cell science 69 19174469
2009 Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis. Modern rheumatology 66 19784544
2016 HDAC7 is overexpressed in human diabetic islets and impairs insulin secretion in rat islets and clonal beta cells. Diabetologia 63 27796421
2004 Cytoplasmic sequestration of HDAC7 from mitochondrial and nuclear compartments upon initiation of apoptosis. The Journal of biological chemistry 62 15364908
2009 Genetic knock-down of HDAC7 does not ameliorate disease pathogenesis in the R6/2 mouse model of Huntington's disease. PloS one 58 19484127
2017 Hdac7 promotes lung tumorigenesis by inhibiting Stat3 activation. Molecular cancer 56 29126425
2022 HDAC7 promotes NSCLC proliferation and metastasis via stabilization by deubiquitinase USP10 and activation of β-catenin-FGF18 pathway. Journal of experimental & clinical cancer research : CR 55 35277183
2013 HDAC7 is a repressor of myeloid genes whose downregulation is required for transdifferentiation of pre-B cells into macrophages. PLoS genetics 55 23696748
2010 The role of histone deacetylase 7 (HDAC7) in cancer cell proliferation: regulation on c-Myc. Journal of molecular medicine (Berlin, Germany) 54 21120446
2001 Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling. The Journal of biological chemistry 54 11262386
2019 A collagen hydrogel loaded with HDAC7-derived peptide promotes the regeneration of infarcted myocardium with functional improvement in a rodent model. Acta biomaterialia 53 30660010
2015 The transcriptional repressor HDAC7 promotes apoptosis and c-Myc downregulation in particular types of leukemia and lymphoma. Cell death & disease 47 25675295
2020 Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling. The Journal of clinical investigation 46 32106109
2008 Cotreatment with BCL-2 antagonist sensitizes cutaneous T-cell lymphoma to lethal action of HDAC7-Nur77-based mechanism. Blood 45 19074726
2014 Histone deacetylase 7 (Hdac7) suppresses chondrocyte proliferation and β-catenin activity during endochondral ossification. The Journal of biological chemistry 44 25389289
2012 The angiogenesis suppressor gene AKAP12 is under the epigenetic control of HDAC7 in endothelial cells. Angiogenesis 42 22584896
2016 In vivo conditional deletion of HDAC7 reveals its requirement to establish proper B lymphocyte identity and development. The Journal of experimental medicine 40 27810920
2013 PP2A regulatory subunit Bα controls endothelial contractility and vessel lumen integrity via regulation of HDAC7. The EMBO journal 40 23955003
2012 HDAC7 inhibits osteoclastogenesis by reversing RANKL-triggered β-catenin switch. Molecular endocrinology (Baltimore, Md.) 40 23204328
2022 Melatonin inhibits ESCC tumor growth by mitigating the HDAC7/β-catenin/c-Myc positive feedback loop and suppressing the USP10-maintained HDAC7 protein stability. Military Medical Research 37 36163081
2019 ZNF326 promotes malignant phenotype of glioma by up-regulating HDAC7 expression and activating Wnt pathway. Journal of experimental & clinical cancer research : CR 35 30691485
2019 HDAC7-mediated control of tumour microenvironment maintains proliferative and stemness competence of human mammary epithelial cells. Molecular oncology 35 31081251
2010 Sp1-dependent activation of HDAC7 is required for platelet-derived growth factor-BB-induced smooth muscle cell differentiation from stem cells. The Journal of biological chemistry 35 20889501
2017 Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells. Cell reports 34 28538176
2017 MiR-489 suppresses tumor growth and invasion by targeting HDAC7 in colorectal cancer. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 34 29071516
2006 Androgen receptor regulates nuclear trafficking and nuclear domain residency of corepressor HDAC7 in a ligand-dependent fashion. Experimental cell research 33 16860317
2018 MC1568 improves insulin secretion in islets from type 2 diabetes patients and rescues β-cell dysfunction caused by Hdac7 upregulation. Acta diabetologica 32 30088095
2016 HDAC7 inhibition resets STAT3 tumorigenic activity in human glioblastoma independently of EGFR and PTEN: new opportunities for selected targeted therapies. Oncogene 32 26853466
2016 Pioglitazone up-regulates long non-coding RNA MEG3 to protect endothelial progenitor cells via increasing HDAC7 expression in metabolic syndrome. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 30 26898430
2022 HDAC7 Activates IKK/NF-κB Signaling to Regulate Astrocyte-Mediated Inflammation. Molecular neurobiology 29 35871708
2020 HDAC7 promotes the oncogenicity of nasopharyngeal carcinoma cells by miR-4465-EphA2 signaling axis. Cell death & disease 29 32376822
2020 MiR-489 inhibited the development of gastric cancer via regulating HDAC7 and PI3K/AKT pathway. World journal of surgical oncology 28 32284070
2013 VEGF-PKD1-HDAC7 signaling promotes endothelial progenitor cell migration and tube formation. Microvascular research 28 24189120
2017 HDAC7 Ubiquitination by the E3 Ligase CBX4 Is Involved in Contextual Fear Conditioning Memory Formation. The Journal of neuroscience : the official journal of the Society for Neuroscience 27 28283560
2021 The TGF-β/HDAC7 axis suppresses TCA cycle metabolism in renal cancer. JCI insight 26 34609963
2013 Valproic acid, but not levetiracetam, selectively decreases HDAC7 and HDAC2 expression in human ovarian cancer cells. Toxicology letters 25 24200999
2011 Autotaxin is induced by TSA through HDAC3 and HDAC7 inhibition and antagonizes the TSA-induced cell apoptosis. Molecular cancer 25 21314984
2024 PROTAC-Mediated HDAC7 Protein Degradation Unveils Its Deacetylase-Independent Proinflammatory Function in Macrophages. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 24 39049738
2022 WNT5A promotes the metastasis of esophageal squamous cell carcinoma by activating the HDAC7/SNAIL signaling pathway. Cell death & disease 24 35595735
2020 OIP5-AS1 modulates epigenetic regulator HDAC7 to enhance non-small cell lung cancer metastasis via miR-140-5p. Oncology letters 24 32774481
2021 HDAC7 Inhibition by Phenacetyl and Phenylbenzoyl Hydroxamates. Journal of medicinal chemistry 23 33570940
2023 HDAC7 is an immunometabolic switch triaging danger signals for engagement of antimicrobial versus inflammatory responses in macrophages. Proceedings of the National Academy of Sciences of the United States of America 19 36649417
2022 KLF2 up-regulates IRF4/HDAC7 to protect neonatal rats from hypoxic-ischemic brain damage. Cell death discovery 19 35091544
2021 The histone deacetylase Hdac7 supports LPS-inducible glycolysis and Il-1β production in murine macrophages via distinct mechanisms. Journal of leukocyte biology 18 34811804
2024 HDAC7 drives glioblastoma to a mesenchymal-like state via LGALS3-mediated crosstalk between cancer cells and macrophages. Theranostics 17 39629136
2025 Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesis. Molecular neurodegeneration 16 39806423
2022 Evidence that HDAC7 acts as an epigenetic "reader" of AR acetylation through NCoR-HDAC3 dissociation. Cell chemical biology 16 35709754
2022 A multiple sclerosis-protective coding variant reveals an essential role for HDAC7 in regulatory T cells. Science translational medicine 16 36516268
2024 HDAC7: a promising target in cancer. Frontiers in oncology 15 38487728
2024 Class IIa HDAC4 and HDAC7 cooperatively regulate gene transcription in Th17 cell differentiation. Proceedings of the National Academy of Sciences of the United States of America 15 38657041
2010 Histone deacetylase 7 (HDAC7) regulates myocyte migration and differentiation. Biochimica et biophysica acta 14 20621129
2004 HDAC7 regulates apoptosis in developing thymocytes. Novartis Foundation symposium 14 15171250
2022 MiR-466b-3p/HDAC7 meditates transgenerational inheritance of testicular testosterone synthesis inhibition induced by prenatal dexamethasone exposure. Biochemical pharmacology 13 35351429
2022 MicroRNAs Promote the Progression of Sepsis-Induced Cardiomyopathy and Neurovascular Dysfunction Through Upregulation of NF-kappaB Signaling Pathway-Associated HDAC7/ACTN4. Frontiers in neurology 13 35756932
2022 HDAC7 inhibits cell proliferation via NudCD1/GGH axis in triple-negative breast cancer. Oncology letters 13 36589669
2024 Mesenchymal Stem Cell-Derived Extracellular Vesicles Alleviate Brain Damage Following Subarachnoid Hemorrhage via the Interaction of miR-140-5p and HDAC7. Molecular neurobiology 12 38592585
2023 HDAC7/c-Myc signaling pathway promotes the proliferation and metastasis of choroidal melanoma cells. Cell death & disease 12 36653340
2021 MiR-342-3p inhibits LCSC oncogenicity and cell stemness through HDAC7/PTEN axis. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 12 34842937
2020 A small molecular compound CC1007 induces cross-lineage differentiation by inhibiting HDAC7 expression and HDAC7/MEF2C interaction in BCR-ABL1- pre-B-ALL. Cell death & disease 11 32913188
2024 Melatonin Attenuates Diabetic Retinopathy by Regulating EndMT of Retinal Vascular Endothelial Cells via Inhibiting the HDAC7/FOXO1/ZEB1 Axis. Journal of pineal research 10 39300782
2025 Nuclear to Cytoplasmic Transport Is a Druggable Dependency in HDAC7-driven Small Cell Lung Cancer. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 9 39887933
2023 LncRNA HOXB-AS4 promotes proliferation and migration of colorectal cancer via the miR-140-5p/hdac7 axis. Biotechnology & genetic engineering reviews 9 36951606
2022 The HDAC7-TET2 epigenetic axis is essential during early B lymphocyte development. Nucleic acids research 9 35904805
2020 HDAC7 is an actionable driver of therapeutic antibody resistance by macrophages from CLL patients. Oncogene 9 32709923
2017 Bisphenol A deteriorates egg quality through HDAC7 suppression. Oncotarget 9 29190921
2013 Holocarboxylase synthetase acts as a biotin-independent transcriptional repressor interacting with HDAC1, HDAC2 and HDAC7. Molecular genetics and metabolism 9 24239178
2023 Deacetylation of FOXP1 by HDAC7 potentiates self-renewal of mesenchymal stem cells. Stem cell research & therapy 8 37507770
2015 HDAC7 modulates TNF-α-mediated suppression of Leydig cell steroidogenesis. Molecular and cellular biochemistry 8 25916381
2014 Rho-kinase signaling controls nucleocytoplasmic shuttling of class IIa histone deacetylase (HDAC7) and transcriptional activation of orphan nuclear receptor NR4A1. Biochemical and biophysical research communications 8 25511694
2025 Discovery of a potential hematologic malignancies therapy: Selective and potent HDAC7 PROTAC degrader targeting non-enzymatic function. Acta pharmaceutica Sinica. B 6 40370550
2024 HDAC7 promotes ovarian cancer malignancy via AKT/mTOR signalling pathway. Journal of cellular and molecular medicine 6 39431349
2024 Toxin protein LukS-PV targeting complement receptor C5aR1 inhibits cell proliferation in hepatocellular carcinoma via the HDAC7-Wnt/β-catenin axis. The Journal of biological chemistry 6 39736396
2020 The black sheep of class IIa: HDAC7 SIKens the heart. The Journal of clinical investigation 6 32364532
2025 ARID1A deficiency promotes malignant proliferation of hepatocellular carcinoma by activating HDAC7/ENO1 signaling pathway. Hepatology communications 5 40536557
2020 Transcription Factor ZNF326 Upregulates the Expression of ERCC1 and HDAC7 and its Clinicopathologic Significance in Glioma. Laboratory medicine 5 31930344
2010 Repetitive busulfan administration after hematopoietic stem cell gene therapy associated with a dominant HDAC7 clone in a nonhuman primate. Human gene therapy 5 20102258
2025 DNMT3a promotes LUAD cell proliferation and metastasis by activating the HDAC7 signalling pathway. International journal of biological sciences 4 39990668
2025 HDAC7 promotes renal cancer progression by reprogramming branched-chain amino acid metabolism. Science advances 4 40465706
2024 The Epigenetic Modifiers HDAC2 and HDAC7 Inversely Associate with Cancer Stemness and Immunity in Solid Tumors. International journal of molecular sciences 4 39063083
2024 Characterization of molecular interactions between HDAC7 and MEF2A. Journal of biomolecular structure & dynamics 4 39660765
2021 FBXW7 induces apoptosis in glioblastoma cells by regulating HDAC7. Cell biology international 4 34288252
2024 HDAC7 is a potential therapeutic target in acute erythroid leukemia. Leukemia 3 39277669
2016 Analysis of Histone Deacetylase 7 (HDAC7) Alternative Splicing and Its Role in Embryonic Stem Cell Differentiation Toward Smooth Muscle Lineage. Methods in molecular biology (Clifton, N.J.) 3 27246210
2025 Scaffolding Activities of Pseudodeacetylase HDAC7. ACS chemical biology 2 39908122
2025 Inhibition of HDAC7 reprograms the histone H3.3 landscape to induce heterochromatin spreading and DNA replication defects in cancer cells. The Journal of biological chemistry 2 40967435
2025 Upregulated astrocytic HDAC7 induces depression-like disorders via deacetylating PINK1 and inhibiting mitophagy. Journal of neuroinflammation 2 41286926