Affinage

OIP5

Protein Mis18-beta · UniProt O43482

Audit flag: alt product
Length
229 aa
Mass
24.7 kDa
Annotated
2026-04-29
100 papers in source corpus 25 papers cited in narrative 25 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

OIP5 encodes both a protein and an antisense long noncoding RNA (OIP5-AS1/cyrano) with distinct functions. The OIP5 protein promotes cell proliferation and survival through AKT/mTOR/β-catenin signaling in cancer contexts and directly interacts with NCK2 to regulate spermatogonial stem cell self-renewal via cell cycle progression (PMID:28184024, PMID:37292517). OIP5-AS1 is a multifunctional lncRNA that operates through diverse mechanisms: it sequesters the RNA-binding protein HuR from proliferative mRNAs, destabilizes GAK mRNA to ensure mitotic spindle fidelity, induces target-directed miRNA decay of miR-7 to promote myoblast fusion via MYMX, recruits EZH2 to epigenetically silence gene promoters, stabilizes hnRNPA1 by blocking its ubiquitination, and physically interacts with AKAP1/calcineurin to inhibit DRP1 dephosphorylation and mitochondrial fission (PMID:26819413, PMID:28472763, PMID:35736212, PMID:31219209, PMID:37897508, PMID:38745296). OIP5-AS1 also functions as a ceRNA sponge for multiple miRNAs in various disease contexts, and its knockout in female mice exacerbates pressure-overload heart failure with dysregulated mitochondrial pathways (PMID:34142046, PMID:32468629).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 2016 High

    The first mechanistic mode of OIP5-AS1 was established when it was shown to physically sequester the RNA-binding protein HuR from its proliferative target mRNAs, revealing OIP5-AS1 as a protein decoy that restrains cell proliferation.

    Evidence MS2-hairpin RNA pulldown, RIP, and functional rescue assays in HeLa cells

    PMID:26819413

    Open questions at the time
    • Whether HuR sequestration is the dominant anti-proliferative mechanism of OIP5-AS1 in vivo
    • Identity of all HuR target mRNAs affected by OIP5-AS1 titration
  2. 2017 High

    OIP5-AS1 was shown to directly regulate mitotic fidelity by binding and destabilizing GAK mRNA, establishing a second distinct mechanistic mode through which the lncRNA controls cell division rather than just proliferative signaling.

    Evidence RNA pulldown, proteomics, genetic rescue, and spindle imaging in HeLa cells

    PMID:28472763

    Open questions at the time
    • Whether OIP5-AS1 recruits a specific mRNA decay factor to GAK mRNA
    • Whether this mechanism operates in non-cancer cells
  3. 2017 Medium

    The OIP5 protein was identified as a driver of hepatocellular carcinoma growth through AKT activation via both mTORC2 and p38/PTEN axes, connecting OIP5 protein function to oncogenic kinase signaling distinct from its antisense lncRNA.

    Evidence Proteome kinase profiling, miRNA PCR array, shRNA knockdown, orthotopic mouse model

    PMID:28184024

    Open questions at the time
    • Direct biochemical mechanism by which OIP5 protein activates AKT
    • Whether OIP5 protein acts as an adaptor, enzyme, or scaffold in this pathway
  4. 2018 Medium

    OIP5 protein was shown to form a positive feedback loop with E2F1 in glioblastoma, where E2F1 transcriptionally activates OIP5 and OIP5 in turn stabilizes E2F1 signaling, linking OIP5 protein to cell cycle transcriptional control.

    Evidence ChIP, co-immunoprecipitation, luciferase assay, orthotopic tumor model

    PMID:29547938

    Open questions at the time
    • Whether OIP5 directly binds E2F1 or acts through an intermediary
    • Mechanism by which OIP5 stabilizes E2F1 activity
  5. 2019 Medium

    OIP5-AS1 was found to recruit EZH2 to specific promoters (GSK-3β, NLRP6), establishing its role as an epigenetic scaffold that guides Polycomb-mediated transcriptional silencing at defined genomic loci.

    Evidence RIP, RNA pulldown, ChIP for EZH2 occupancy, rescue experiments in HUVECs and gastric cancer cells

    PMID:30972206 PMID:31219209

    Open questions at the time
    • Whether OIP5-AS1 contains a specific EZH2-binding structural motif
    • Genome-wide scope of EZH2 recruitment by OIP5-AS1
    • Independent replication of EZH2-guided silencing at these specific loci
  6. 2020 Medium

    OIP5-AS1 was linked to mitochondrial quality control in cardiomyocytes, where it modulates the SIRT1/AMPK/PGC1α axis via miR-29a sponging and regulates POLG-dependent mitochondrial DNA maintenance through HuR scaffolding in lens epithelial cells.

    Evidence RIP, dual-luciferase assay, pharmacological inhibition (EX527), rat MI/R model; RIP-qPCR and ChIP in cataract lens samples

    PMID:32468629 PMID:33006594

    Open questions at the time
    • Whether miR-29a sponging versus direct protein interaction is the primary cardioprotective mechanism
    • Relative contribution of HuR-dependent versus HuR-independent pathways
  7. 2021 High

    OIP5 protein was demonstrated to directly interact with NCK2 in spermatogonial stem cells to regulate self-renewal, establishing a physiological non-cancer role for the OIP5 protein with reconstitution-level binding evidence.

    Evidence Co-IP, IP-mass spectrometry, GST pulldown, siRNA rescue, flow cytometry in human SSCs

    PMID:37292517

    Open questions at the time
    • Structural basis of OIP5–NCK2 interaction
    • Whether NCK2 is the only direct effector of OIP5 in SSC self-renewal
  8. 2021 Medium

    Global OIP5-AS1 knockout in mice revealed a sex-specific cardiac phenotype — female mice developed worsened heart failure after pressure overload — establishing an in vivo physiological requirement for OIP5-AS1 in cardiac stress responses.

    Evidence CRISPR knockout mouse, transverse aortic constriction model, echocardiography, RNA-seq

    PMID:34142046

    Open questions at the time
    • Molecular basis of the female-specific phenotype
    • Which OIP5-AS1 mechanism (protein sponging, miRNA decay, EZH2 recruitment, etc.) is responsible for cardioprotection
  9. 2022 High

    OIP5-AS1 was shown to induce target-directed miRNA degradation (TDMD) of miR-7 during human myogenesis, de-repressing the fusogen MYMX to drive myoblast fusion — establishing a fundamentally different mechanistic mode (miRNA destruction rather than miRNA sponging).

    Evidence miR-7 decay assays, MYMX rescue, oligonucleotide site-blocker, gain/loss-of-function in human myoblasts

    PMID:35736212

    Open questions at the time
    • Whether TDMD of miR-7 requires ZSWIM8 or another E3 ligase
    • Whether OIP5-AS1 triggers TDMD of additional miRNAs beyond miR-7
  10. 2023 High

    OIP5-AS1 was found to stabilize hnRNPA1 protein by preventing Trim21-mediated ubiquitination, and to recruit the E3 ligase ITCH to promote TXNIP degradation, establishing OIP5-AS1 as a direct modulator of ubiquitin-proteasome pathways for specific protein targets.

    Evidence RNA pulldown, RIP, Co-IP, ubiquitination assays, patient-derived xenograft (gastric cancer); MCAO/R mouse model (neuronal pyroptosis)

    PMID:37897508 PMID:38103409

    Open questions at the time
    • Structural basis of how OIP5-AS1 shields hnRNPA1 from Trim21
    • Whether ITCH recruitment is a general mechanism or specific to exosomal OIP5-AS1
  11. 2024 High

    The cardioprotective mechanism was refined: OIP5-AS1 directly interacts with AKAP1 and calcineurin to block DRP1 dephosphorylation at Ser637, thereby preventing mitochondrial fission during ischemia-reperfusion injury.

    Evidence RNA pulldown, RIP, Co-IP, CRISPR KO mouse, AAV9 overexpression, pharmacological rescue with Mdivi-1, TEM

    PMID:38745296

    Open questions at the time
    • Whether OIP5-AS1 forms a ternary complex with AKAP1 and calcineurin simultaneously
    • Whether this mechanism explains the sex-specific cardiac phenotype of OIP5-AS1 KO mice

Open questions

Synthesis pass · forward-looking unresolved questions
  • Major unresolved questions include: the structural determinants of OIP5-AS1 that enable its diverse protein and miRNA interactions; whether OIP5 protein and OIP5-AS1 lncRNA are coordinately regulated or functionally independent; and the basis of female-specific cardiac susceptibility upon OIP5-AS1 loss.
  • No structural model of OIP5-AS1 functional domains
  • No systematic study of OIP5 protein versus OIP5-AS1 lncRNA co-regulation
  • No mechanism for sex-specific cardiac phenotype

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 6 GO:0098772 molecular function regulator activity 3 GO:0060090 molecular adaptor activity 2 GO:0140110 transcription regulator activity 2
Localization
GO:0005829 cytosol 4 GO:0005634 nucleus 3 GO:0005739 mitochondrion 3
Pathway
R-HSA-1640170 Cell Cycle 4 R-HSA-5357801 Programmed Cell Death 3 R-HSA-8953854 Metabolism of RNA 3 R-HSA-162582 Signal Transduction 2 R-HSA-1852241 Organelle biogenesis and maintenance 2 R-HSA-4839726 Chromatin organization 2
Partners
AKAP1E2F1EZH2HNRNPA1HURIGF2BP3NCK2

Evidence

Reading pass · 25 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2016 LncRNA OIP5-AS1 acts as a competing endogenous RNA (ceRNA) for the RNA-binding protein HuR: OIP5-AS1 physically associates with HuR, and high levels of OIP5-AS1 sequester HuR away from its target mRNAs (including those encoding proliferative proteins), thereby reducing cell proliferation. miR-424 competes with HuR for binding to OIP5-AS1. MS2-hairpin RNA pulldown to identify associated miRNAs, RIP, functional HuR-mRNA interaction assays, gain/loss-of-function in HeLa cells Nucleic acids research High 26819413
2017 LncRNA OIP5-AS1/cyrano suppresses cell proliferation by reducing GAK (cyclin G-associated kinase) mRNA stability and protein abundance; OIP5-AS1 associates with GAK mRNA, and silencing OIP5-AS1 causes aberrant mitotic spindles (monopolar, multipolar, misaligned), which are partially rescued by simultaneous GAK silencing. RNA pulldown of OIP5-AS1-associated mRNAs, proteomics of differentially expressed proteins upon OIP5-AS1 silencing, gain/loss-of-function, mitotic spindle imaging in HeLa cells Oncotarget High 28472763
2022 During human myogenesis, OIP5-AS1 binds miR-7 and induces its decay via target RNA-directed miRNA degradation (TDMD), thereby de-repressing the miR-7 target MYMX mRNA (encoding myomixer fusogen) to promote myoblast fusion into multinucleated myotubes. An oligonucleotide site-blocker that disrupts OIP5-AS1–miR-7 interaction allows miR-7 to accumulate, lowering MYMX and suppressing myotube formation. lncRNA/miRNA interaction mapping, miR-7 decay assays, MYMX expression rescue, oligonucleotide site-blocker experiments, gain/loss-of-function in human myoblasts Nucleic acids research High 35736212
2019 LncRNA OIP5-AS1 recruits the PRC2 component EZH2 to the GSK-3β promoter, reducing GSK-3β expression via histone methylation, thereby accelerating ox-LDL-mediated vascular endothelial cell apoptosis. ChIP confirmed direct EZH2 binding to the GSK-3β promoter region in this context. ChIP assay, siRNA knockdown, rescue experiments in HUVECs American journal of translational research Medium 30972206
2019 LncRNA OIP5-AS1 is predominantly localized in the nucleus of hepatoblastoma cells and acts as a ceRNA, binding miR-186a-5p to upregulate its target ZEB1, promoting EMT and tumor cell proliferation/metastasis. Nuclear-cytoplasmic fractionation, RIP assay, dual-luciferase assay, rescue assay Biomedicine & pharmacotherapy Medium 29475118
2017 OIP5 protein promotes hepatocellular carcinoma growth and metastasis by activating AKT through both mTORC2 and p38/PTEN, which links to mTORC1 (cell growth) and GSK-3β/β-catenin (metastasis) signaling. miR-15b-5p targets OIP5 mRNA and suppresses these oncogenic pathways. Proteome kinase profiling, miRNA PCR array, shRNA knockdown, orthotopic mouse model, Western blotting Oncotarget Medium 28184024
2018 OIP5 is transcriptionally activated by E2F1 and in turn stabilizes E2F1 signaling in glioblastoma, forming a positive feedback loop that promotes cell cycle progression, proliferation, and metastasis. E2F1 binding to the OIP5 promoter was confirmed by ChIP; OIP5 interaction with E2F1 complex was confirmed by co-immunoprecipitation and luciferase assay. Co-immunoprecipitation, ChIP, luciferase reporter assay, shRNA knockdown, orthotopic tumor model Neuro-oncology Medium 29547938
2021 OIP5 protein interacts directly with NCK2 in human spermatogonial stem cells (SSCs) to regulate their self-renewal and apoptosis through cell cycle progression (including cyclin D1, A2, B1, E1, H levels). OIP5–NCK2 interaction was confirmed by co-IP, IP-mass spectrometry, and GST pulldown; NCK2 knockdown reversed OIP5-overexpression effects on SSC proliferation. Co-immunoprecipitation, IP-mass spectrometry, GST pulldown, RNA-seq, siRNA knockdown, flow cytometry Research (Washington, D.C.) High 37292517
2020 Oip5-as1 sponges miR-29a to de-repress SIRT1 expression, activating the AMPK/PGC1α pathway and reducing mitochondria-mediated apoptosis during myocardial ischemia/reperfusion injury. miR-29a overexpression reversed the anti-apoptotic effect of Oip5-as1; SIRT1 inhibition (EX527) blocked the protective pathway. Dual-luciferase assay, RIP assay, gain/loss-of-function in H9c2 cells, rat MI/R model, pharmacological inhibition Cell proliferation Medium 32468629
2024 Oip5-as1 selectively interacts with AKAP1 and calcineurin (CaN) proteins, inhibiting CaN activation and the consequent dephosphorylation of DRP1 at Ser637, thereby preventing DRP1 translocation to mitochondria and excessive mitochondrial fission during myocardial ischemia/reperfusion injury. RNA pulldown, RIP, co-immunoprecipitation, Western blotting, CRISPR knockout mouse, AAV9 overexpression, transmission electron microscopy, echocardiography Cellular & molecular biology letters High 38745296
2021 Female-specific exacerbation of heart failure: global OIP5-AS1 knockout female mice (but not male mice) develop worsened cardiac function after transverse aortic constriction, with RNA-seq indicating dysregulated mitochondrial function pathways. CRISPR knockout mouse generation, transverse aortic constriction model, echocardiography, RNA-sequencing iScience Medium 34142046
2023 OIP5-AS1 is stabilized by m6A modification via IGF2BP3 binding to m6A sites on OIP5-AS1. OIP5-AS1 in turn binds hnRNPA1 protein and prevents its Trim21-mediated ubiquitination and degradation, stabilizing hnRNPA1 which promotes PKM2-mediated glycolysis and gastric cancer malignant progression. RNA pulldown, RIP, Co-IP, ubiquitination assay, patient-derived xenograft, bioinformatics, Western blot Gastric cancer High 37897508
2021 SUMOylation of IGF2BP2 at K497, K505, and K509 (removable by SENP1) increases IGF2BP2 protein stability by blocking ubiquitin-proteasome degradation, and SUMOylated IGF2BP2 enhances OIP5-AS1 stability; elevated OIP5-AS1 sequesters miR-495-3p, de-repressing HIF1A and MMP14 to promote vasculogenic mimicry in glioma. Ni2+-NTA agarose bead pulldown, Co-IP, in vitro SUMOylation assay, immunoprecipitation, RIP, luciferase assay, xenograft model International journal of biological sciences Medium 34345216
2023 Exosome-derived OIP5-AS1 (from M2 microglia) recruits the E3 ubiquitin ligase ITCH to TXNIP, promoting TXNIP ubiquitination and proteasomal degradation, thereby reducing TXNIP protein (but not mRNA) levels, inhibiting neuronal pyroptosis and attenuating cerebral ischemia-reperfusion injury. RNA pulldown, RIP, Co-IP, ubiquitination assay, MCAO/R mouse model, OGD/R cell model International immunopharmacology Medium 38103409
2020 LncRNA OIP5-AS1 is localized predominantly in the cytoplasm in cervical cancer cells (OIP5-AS1-targeting siRNA studies) and acts as a ceRNA for miR-143-3p to upregulate ROCK1, promoting cervical cancer cell proliferation and inhibiting apoptosis. siRNA knockdown, CCK-8, flow cytometry, luciferase assay (indirect localization inferred); previous fractionation cited in related work Brazilian journal of medical and biological research Low 31939597
2020 LncRNA OIP5-AS1 contributes to cataract formation by acting as a scaffold: HuR protein binds both OIP5-AS1 and POLG mRNA, mediating POLG mRNA decay, which reduces mitochondrial DNA copy number and membrane potential, increasing ROS and apoptosis in lens epithelial cells. TFAP2A transcription factor binds the OIP5-AS1 promoter to drive its expression. RIP-qPCR (OIP5-AS1–HuR–POLG interaction), ChIP-qPCR (TFAP2A on OIP5-AS1 promoter), flow cytometry, Western blot, clinical cataract lens samples and ex vivo model Investigative ophthalmology & visual science Medium 33006594
2018 In glioma cells, PIWIL3/piR-30188 complex binds to and degrades OIP5-AS1; OIP5-AS1 functions as a ceRNA for miR-367-3p, de-repressing CEBPA, which in turn transcriptionally activates PIWIL3 forming a regulatory feedback loop. CEBPA also regulates TRAF4 downstream. Binding sites confirmed by RIP and luciferase assay. RIP, luciferase assay, cell/animal models, RNA expression analysis Theranostics Medium 29464001
2019 In KSHV-infected endothelial cells, viral oncoprotein vIRF1 inhibits p53 to increase DNMT1 expression, causing DNA methylation of the pre-miR-218-1 promoter and reducing miR-218-5p levels; vIRF1 also increases OIP5-AS1 expression, which acts as a ceRNA for miR-218-5p to further suppress its function and stability, promoting HMGB2 and CMPK1 expression and tumor cell invasion. lnc-OIP5-AS1 also increases DNA methylation of pre-miR-218-1 promoter. ChIP, luciferase assay, KSHV vIRF1 deletion mutant, RIP, gain/loss-of-function in endothelial cells PLoS pathogens Medium 30699189
2017 OIP5 knockdown via siRNA in colorectal and gastric cancer cell lines inhibits growth; in SNU638 cells, knockdown increases sub-G1 DNA content and produces an apoptotic gene expression profile, indicating OIP5 promotes cell survival and its depletion induces apoptosis. siRNA knockdown, flow cytometry (sub-G1 analysis), apoptosis gene expression profiling BMB reports Low 20510019
2018 OIP5 promotes bladder cancer growth, migration, and cisplatin resistance. RNA-seq of OIP5-knockdown cells identified overlapping DEGs enriched in oocyte meiosis, Fanconi anemia pathway, and cell cycle regulation. shRNA knockdown, RNA-seq, transwell assay, cisplatin sensitivity assay, in vivo xenograft Journal of Cancer Low 30588253
2017 OIP5-AS1 silencing causes G2/M phase cell cycle arrest (without apoptosis) in HeLa cells. OIP5-AS1 expression is lower in cells harboring oncogenic K-RAS mutation compared to wild-type K-RAS cells. siRNA and antisense oligonucleotide knockdown, cell cycle analysis by flow cytometry, apoptosis analysis Anticancer research Low 29277759
2024 Oip5-as1 delivery via lipid nanoparticles inhibits the p53 signaling pathway to preserve mitochondrial function and reduce apoptosis in myocardial ischemia/reperfusion injury; cardioprotective effects were abrogated by the p53 activator Nutlin-3a. LNP-mediated lncRNA delivery, H/R cell model, coronary artery ligation mouse model, pharmacological p53 activation (Nutlin-3a), echocardiography ACS applied materials & interfaces Medium 39485791
2021 Linc-OIP5 (OIP5 protein-coding gene locus) knockdown in glioma cells inhibits proliferation and migration at least partially through downregulation of YAP and inhibition of Notch signaling pathway activity. siRNA knockdown, qRT-PCR, Western blot, in vitro proliferation/migration assays, in vivo tumor formation Gene Low 28189759
2020 Linc-OIP5 in breast cancer cells promotes angiogenesis of co-cultured HUVECs via a YAP1/Notch/NRP1 signaling circuit; linc-OIP5 knockdown reduces YAP1 and JAG1 in cancer cells and decreases JAG1 in conditioned medium, disrupting DLL4/Notch/NRP1 signaling in HUVECs. siRNA knockdown in co-culture transwell system, Western blot, ELISA of conditioned medium, tube formation assay Biological research Low 32046779
2019 LncRNA OIP5-AS1 binds EZH2 and epigenetically silences NLRP6 expression in gastric cancer cells, promoting cell proliferation and migration. OIP5-AS1 is mainly localized in the nucleus in gastric cancer cells. RIP/RNA pulldown (OIP5-AS1–EZH2 interaction), nuclear-cytoplasmic fractionation, ChIP, siRNA knockdown Journal of cellular biochemistry Medium 31219209

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2021 LncRNA OIP5-AS1 inhibits ferroptosis in prostate cancer with long-term cadmium exposure through miR-128-3p/SLC7A11 signaling. Ecotoxicology and environmental safety 152 34051661
2016 LncRNA OIP5-AS1/cyrano sponges RNA-binding protein HuR. Nucleic acids research 149 26819413
2017 LncRNA OIP5-AS1 loss-induced microRNA-410 accumulation regulates cell proliferation and apoptosis by targeting KLF10 via activating PTEN/PI3K/AKT pathway in multiple myeloma. Cell death & disease 135 28796257
2018 PIWIL3/OIP5-AS1/miR-367-3p/CEBPA feedback loop regulates the biological behavior of glioma cells. Theranostics 117 29464001
2018 LncRNA OIP5-AS1 regulates radioresistance by targeting DYRK1A through miR-369-3p in colorectal cancer cells. European journal of cell biology 96 29773344
2018 Long noncoding RNA OIP5-AS1 causes cisplatin resistance in osteosarcoma through inducing the LPAATβ/PI3K/AKT/mTOR signaling pathway by sponging the miR-340-5p. Journal of cellular biochemistry 96 30548308
2020 lncRNA Oip5-as1 attenuates myocardial ischaemia/reperfusion injury by sponging miR-29a to activate the SIRT1/AMPK/PGC1α pathway. Cell proliferation 84 32468629
2017 Long non-coding RNA OIP5-AS1 functions as an oncogene in lung adenocarcinoma through targeting miR-448/Bcl-2. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 78 29247949
2021 Cancer-associated fibroblasts-derived exosomes promote lung cancer progression by OIP5-AS1/ miR-142-5p/ PD-L1 axis. Molecular immunology 62 34653794
2021 Up-regulating lncRNA OIP5-AS1 protects neuron injury against cerebral hypoxia-ischemia induced inflammation and oxidative stress in microglia/macrophage through activating CTRP3 via sponging miR-186-5p. International immunopharmacology 60 33516048
2018 Fibronectin-1 modulated by the long noncoding RNA OIP5-AS1/miR-200b-3p axis contributes to doxorubicin resistance of osteosarcoma cells. Journal of cellular physiology 60 30204936
2018 Kockdown of OIP5-AS1 expression inhibits proliferation, metastasis and EMT progress in hepatoblastoma cells through up-regulating miR-186a-5p and down-regulating ZEB1. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 55 29475118
2021 Highly enriched exosomal lncRNA OIP5-AS1 regulates osteosarcoma tumor angiogenesis and autophagy through miR-153 and ATG5. American journal of translational research 53 34150009
2018 Long noncoding RNA OIP5-AS1 accelerates CDK14 expression to promote osteosarcoma tumorigenesis via targeting miR-223. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 53 30119217
2021 SUMOylation of IGF2BP2 promotes vasculogenic mimicry of glioma via regulating OIP5-AS1/miR-495-3p axis. International journal of biological sciences 49 34345216
2018 LncRNA OIP5-AS1 is overexpressed in undifferentiated oral tumors and integrated analysis identifies as a downstream effector of stemness-associated transcription factors. Scientific reports 48 29728583
2021 METTL14 promotes tumorigenesis by regulating lncRNA OIP5-AS1/miR-98/ADAMTS8 signaling in papillary thyroid cancer. Cell death & disease 47 34131102
2019 Long noncoding RNA OIP5-AS1 targets Wnt-7b to affect glioma progression via modulation of miR-410. Bioscience reports 46 30498093
2019 Long noncoding RNA OIP5-AS1 accelerates the ox-LDL mediated vascular endothelial cells apoptosis through targeting GSK-3β via recruiting EZH2. American journal of translational research 46 30972206
2010 OIP5 is a highly expressed potential therapeutic target for colorectal and gastric cancers. BMB reports 46 20510019
2019 Oncogenic KSHV-encoded interferon regulatory factor upregulates HMGB2 and CMPK1 expression to promote cell invasion by disrupting a complex lncRNA-OIP5-AS1/miR-218-5p network. PLoS pathogens 43 30699189
2017 Knockdown of linc-OIP5 inhibits proliferation and migration of glioma cells through down-regulation of YAP-NOTCH signaling pathway. Gene 43 28189759
2020 Downregulation of LncRNA OIP5-AS1 Induced by IL-1β Aggravates Osteoarthritis via Regulating miR-29b-3p/PGRN. Cartilage 42 32037864
2019 Long noncoding RNA OIP5-AS1 promotes the progression of oral squamous cell carcinoma via regulating miR-338-3p/NRP1 axis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 40 31369989
2019 Long noncoding RNA OIP5-AS1 in cancer. Clinica chimica acta; international journal of clinical chemistry 40 31476304
2020 LncRNA OIP5-AS1 promotes the malignancy of pancreatic ductal adenocarcinoma via regulating miR-429/FOXD1/ERK pathway. Cancer cell international 39 32669972
2017 OIP5, a target of miR-15b-5p, regulates hepatocellular carcinoma growth and metastasis through the AKT/mTORC1 and β-catenin signaling pathways. Oncotarget 39 28184024
2020 Long noncoding RNA OIP5-AS1 mediates resistance to doxorubicin by regulating miR-137-3p/PTN axis in osteosarcoma. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 37 32460190
2019 Long noncoding RNA OIP5-AS1 aggravates cell proliferation, migration in gastric cancer by epigenetically silencing NLRP6 expression via binding EZH2. Journal of cellular biochemistry 34 31219209
2020 LncRNA OIP5-AS1 Promotes Breast Cancer Progression by Regulating miR-216a-5p/GLO1. The Journal of surgical research 33 32916503
2019 LncRNA OIP5-AS1 Promotes the Proliferation of Hemangioma Vascular Endothelial Cells via Regulating miR-195-5p/NOB1 Axis. Frontiers in pharmacology 33 31068824
2020 OIP5-AS1/miR-137/ZNF217 Axis Promotes Malignant Behaviors in Epithelial Ovarian Cancer. Cancer management and research 32 32801903
2017 LncRNA OIP5-AS1/cyrano suppresses GAK expression to control mitosis. Oncotarget 32 28472763
2006 Opa interacting protein 5 (OIP5) is a novel cancer-testis specific gene in gastric cancer. Annals of surgical oncology 32 17151793
2023 N6-methyladenosine modification of OIP5-AS1 promotes glycolysis, tumorigenesis, and metastasis of gastric cancer by inhibiting Trim21-mediated hnRNPA1 ubiquitination and degradation. Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 31 37897508
2021 A review on the role of oncogenic lncRNA OIP5-AS1 in human malignancies. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 31 33601149
2019 Long noncoding RNA OIP5-AS1 acts as a competing endogenous RNA to promote glutamine catabolism and malignant melanoma growth by sponging miR-217. Journal of cellular physiology 31 30779126
2021 Long non-coding RNA OIP5-AS1 inhibition upregulates microRNA-129-5p to repress resistance to temozolomide in glioblastoma cells via downregulating IGF2BP2. Cell biology and toxicology 30 34132932
2020 Long non-coding RNA OIP5-AS1 promotes the growth of gastric cancer through the miR-367-3p/HMGA2 axis. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 30 31959478
2018 Cancer-testis specific gene OIP5: a downstream gene of E2F1 that promotes tumorigenesis and metastasis in glioblastoma by stabilizing E2F1 signaling. Neuro-oncology 30 29547938
2020 lncRNA OIP5-AS1 targets ROCK1 to promote cell proliferation and inhibit cell apoptosis through a mechanism involving miR-143-3p in cervical cancer. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 29 31939597
2020 Long non-coding RNA OIP5-AS1 suppresses multiple myeloma progression by sponging miR-27a-3p to activate TSC1 expression. Cancer cell international 29 32410883
2020 Long Non-Coding RNA OIP5-AS1 Knockdown Enhances CDDP Sensitivity in Osteosarcoma via miR-377-3p/FOSL2 Axis. OncoTargets and therapy 29 32440152
2020 Inhibitory role of long non-coding RNA OIP5-AS1 in rheumatoid arthritis progression through the microRNA-448-paraoxonase 1-toll-like receptor 3-nuclear factor κB axis. Experimental physiology 29 32770578
2018 The Long Noncoding RNA OIP5-AS1 Is Involved in the Regulation of Cell Proliferation. Anticancer research 29 29277759
2013 Expression analysis of four testis-specific genes AURKC, OIP5, PIWIL2 and TAF7L in acute myeloid leukemia: a gender-dependent expression pattern. Medical oncology (Northwood, London, England) 29 23292864
2021 Exosomal-mediated transfer of OIP5-AS1 enhanced cell chemoresistance to trastuzumab in breast cancer via up-regulating HMGB3 by sponging miR-381-3p. Open medicine (Warsaw, Poland) 27 33821219
2021 LncRNA OIP5-AS1 accelerates intervertebral disc degeneration by targeting miR-25-3p. Bioengineered 27 34872452
2020 Long non-coding RNA OIP5-AS1 promotes pancreatic cancer cell growth through sponging miR-342-3p via AKT/ERK signaling pathway. Journal of physiology and biochemistry 27 32157498
2020 LncRNA OIP5-AS1 facilitates ox-LDL-induced endothelial cell injury through the miR-98-5p/HMGB1 axis. Molecular and cellular biochemistry 27 32990894
2019 LncRNA OIP5-AS1 inhibits osteoblast differentiation of valve interstitial cells via miR-137/TWIST11 axis. Biochemical and biophysical research communications 27 30846207
2022 Long non-coding RNA OIP5-AS1 (Cyrano): A context-specific regulator of normal and disease processes. Clinical and translational medicine 26 35040588
2020 LncRNA OIP5-AS1 promotes cell proliferation and migration and induces angiogenesis via regulating miR-3163/VEGFA in hepatocellular carcinoma. Cancer biology & therapy 26 32329664
2023 Exosomal OIP5-AS1 attenuates cerebral ischemia-reperfusion injury by negatively regulating TXNIP protein stability and inhibiting neuronal pyroptosis. International immunopharmacology 25 38103409
2022 lncRNA OIP5-AS1 knockdown or miR-223 overexpression can alleviate LPS-induced ALI/ARDS by interfering with miR-223/NLRP3-mediated pyroptosis. The journal of gene medicine 25 34346534
2020 Linc-OIP5 in the breast cancer cells regulates angiogenesis of human umbilical vein endothelial cells through YAP1/Notch/NRP1 signaling circuit at a tumor microenvironment. Biological research 25 32046779
2023 LncRNA OIP5-AS1/miR-410-3p/Wnt7b axis promotes the proliferation of rheumatoid arthritis fibroblast-like synoviocytes via regulating the Wnt/β-catenin pathway. Autoimmunity 24 36942896
2020 OIP5-AS1 modulates epigenetic regulator HDAC7 to enhance non-small cell lung cancer metastasis via miR-140-5p. Oncology letters 24 32774481
2018 OIP5 Promotes Growth, Metastasis and Chemoresistance to Cisplatin in Bladder Cancer Cells. Journal of Cancer 23 30588253
2022 The role of lncRNA OIP5-AS1 in cancer development and progression. Apoptosis : an international journal on programmed cell death 22 35316453
2021 LncRNA OIP5-AS1 Promotes the Autophagy-Related Imatinib Resistance in Chronic Myeloid Leukemia Cells by Regulating miR-30e-5p/ATG12 Axis. Technology in cancer research & treatment 22 34723728
2020 LncRNA OIP5-AS1 interacts with miR-363-3p to contribute to hepatocellular carcinoma progression through up-regulation of SOX4. Gene therapy 22 32042127
2020 Long non coding RNA OIP5‑AS1 promotes metastasis of breast cancer via miR‑340‑5p/ZEB2 axis. Oncology reports 22 32945479
2020 Long Noncoding RNA OIP5-AS1 Promotes Cell Apoptosis and Cataract Formation by Blocking POLG Expression Under Oxidative Stress. Investigative ophthalmology & visual science 22 33006594
2019 Long non-coding RNA OIP5-AS1 promotes proliferation of gastric cancer cells by targeting miR-641. European review for medical and pharmacological sciences 22 31858545
2024 lncRNA Oip5-as1 inhibits excessive mitochondrial fission in myocardial ischemia/reperfusion injury by modulating DRP1 phosphorylation. Cellular & molecular biology letters 21 38745296
2022 LncRNA OIP5-AS1-directed miR-7 degradation promotes MYMX production during human myogenesis. Nucleic acids research 21 35736212
2021 LncRNA OIP5-AS1 reduces renal epithelial cell apoptosis in cisplatin-induced AKI by regulating the miR-144-5p/PKM2 axis. Biomedical journal 21 34311128
2021 lncRNA OIP5-AS1 Suppresses Cell Proliferation and Invasion of Endometrial Cancer by Regulating PTEN/AKT via Sponging miR-200c-3p. Journal of immunology research 21 34368370
2020 Long non-coding RNA OIP5-AS1 serves as an oncogene in laryngeal squamous cell carcinoma by regulating miR-204-5p/ZEB1 axis. Naunyn-Schmiedeberg's archives of pharmacology 21 32009213
2020 Long non-coding RNA OIP5-AS1 plays an oncogenic role in ovarian cancer through targeting miR-324-3p/NFIB axis. European review for medical and pharmacological sciences 21 32706064
2021 LncRNA OIP5-AS1 Regulates the Warburg Effect Through miR-124-5p/IDH2/HIF-1α Pathway in Cervical Cancer. Frontiers in cell and developmental biology 20 34513821
2020 LncRNA OIP5‑AS1 aggravates house dust mite‑induced inflammatory responses in human bronchial epithelial cells via the miR‑143‑3p/HMGB1 axis. Molecular medicine reports 20 33174035
2021 Long non-coding RNA OIP5-AS1 contributes to cisplatin resistance of oral squamous cell carcinoma through the miR-27b-3p/TRIM14 axis. Experimental and therapeutic medicine 19 33692839
2021 Molecular mechanism of miR-34b-5p and RNA binding protein HuR binding to lncRNA OIP5-AS1 in colon cancer cells. Cancer gene therapy 19 34021273
2021 Loss of the long non-coding RNA OIP5-AS1 exacerbates heart failure in a sex-specific manner. iScience 19 34142046
2021 Overexpressing long non-coding RNA OIP5-AS1 ameliorates sepsis-induced lung injury in a rat model via regulating the miR-128-3p/Sirtuin-1 pathway. Bioengineered 19 34592882
2020 LNCRNA OIP5-AS1 regulates oxidative low-density lipoprotein-mediated endothelial cell injury via miR-320a/LOX1 axis. Molecular and cellular biochemistry 19 32072428
2020 OIP5-AS1 promotes the progression of gastric cancer cells via the miR-153-3p/ZBTB2 axis. European review for medical and pharmacological sciences 19 32196594
2020 Long Noncoding RNA OIP5-AS1 Promotes the Progression of Liver Hepatocellular Carcinoma via Regulating the hsa-miR-26a-3p/EPHA2 Axis. Molecular therapy. Nucleic acids 19 32585630
2015 Cancer/Testis OIP5 and TAF7L Genes are Up-Regulated in Breast Cancer. Asian Pacific journal of cancer prevention : APJCP 19 26107214
2022 Tetramethylpyrazine and Astragaloside IV have synergistic effects against spinal cord injury-induced neuropathic pain via the OIP5-AS1/miR-34a/Sirt1/NF-κB axis. International immunopharmacology 18 36577153
2020 LncRNA OIP5-AS1 upregulates snail expression by sponging miR-34a to promote ovarian carcinoma cell invasion and migration. Biological research 18 33092644
2023 OIP5 Interacts with NCK2 to Mediate Human Spermatogonial Stem Cell Self-Renewal and Apoptosis through Cell Cyclins and Cycle Progression and Its Abnormality Is Correlated with Male Infertility. Research (Washington, D.C.) 17 37292517
2021 Long non‑coding RNA OIP5‑AS1 facilitates the progression of ovarian cancer via the miR‑128‑3p/CCNG1 axis. Molecular medicine reports 16 33760168
2020 OIP5-AS1 Attenuates Microangiopathy in Diabetic Mouse by Regulating miR-200b/ACE2. World neurosurgery 16 32200014
2020 Long Noncoding RNA OIP5-AS1 Contributes to the Progression of Atherosclerosis by Targeting miR-26a-5p Through the AKT/NF-κB Pathway. Journal of cardiovascular pharmacology 16 32833899
2019 Integrative analysis of OIP5-AS1/HUR1 to discover new potential biomarkers and therapeutic targets in multiple sclerosis. Journal of cellular physiology 16 30815864
2022 Long non-coding RNA OIP5-AS1 suppresses microRNA-92a to augment proliferation and metastasis of ovarian cancer cells through upregulating ITGA6. Journal of ovarian research 15 35168644
2020 LncRNA OIP5-AS1 facilitates gastric cancer cell growth by targeting the miR-422a/ANO1 axis. Acta biochimica et biophysica Sinica 15 32147682
2019 Linc-OIP5 loss regulates migration and invasion in MDA-MB-231 breast cancer cells by inhibiting YAP1/JAG1 signaling. Oncology letters 15 31897120
2024 Lipid Nanoparticle-Mediated Oip5-as1 Delivery Preserves Mitochondrial Function in Myocardial Ischemia/Reperfusion Injury by Inhibiting the p53 Pathway. ACS applied materials & interfaces 14 39485791
2018 Expression Analysis of OIP5-AS1 in Non-Small Cell Lung Cancer. Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti 14 30541307
2022 OIP5-AS1 Inhibits Oxidative Stress and Inflammation in Ischemic Stroke Through miR-155-5p/IRF2BP2 Axis. Neurochemical research 13 36460840
2021 Lnc-OIP5-AS1 exacerbates aorta wall injury during the development of aortic dissection through upregulating TUB via sponging miR-143-3p. Life sciences 13 33577845
2021 Long non-coding RNA OIP5-AS1 aggravates acute lung injury by promoting inflammation and cell apoptosis via regulating the miR-26a-5p/TLR4 axis. BMC pulmonary medicine 13 34261477
2021 OIP5-AS1 contributes to the development in endometrial carcinoma cells by targeting miR-152-3p to up-regulate SLC7A5. Cancer cell international 13 34419049
2020 LncRNA OIP5-AS1 induces epithelial-to-mesenchymal transition and renal fibrosis in diabetic nephropathy via binding to miR-30c-5p. Journal of biological regulators and homeostatic agents 13 32519534
2020 OIP5-AS1 contributes to tumorigenesis in hepatocellular carcinoma by miR-300/YY1-activated WNT pathway. Cancer cell international 13 32943988
2021 Long non-coding RNA OIP5-AS1 regulates smoke-related chronic obstructive pulmonary disease via targeting micro RNA -410-3p/IL-13. Bioengineered 12 34872453