Affinage

OIP5

Protein Mis18-beta · UniProt O43482

Audit flag: wrong gene
Length
229 aa
Mass
24.7 kDa
Annotated
2026-06-10
100 papers in source corpus 21 papers cited in narrative 21 extracted findings
Cross-family judge vs UniProt: tie faithfulness: 5/6 claims corpus-supported (83%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

The OIP5 locus encodes two functionally distinct products: a protein-coding OIP5 transcript that acts as a pro-proliferative oncoprotein, and the antisense long noncoding RNA OIP5-AS1, a multifunctional regulator of RNA stability, miRNA decay, epigenetic silencing, and protein turnover (PMID:20510019, PMID:26819413). The OIP5 protein promotes cell survival and cell-cycle progression across colorectal, gastric, hepatocellular, bladder, and glioblastoma cells, where its loss induces growth inhibition and sub-G1 accumulation (PMID:20510019, PMID:30588253). Mechanistically, OIP5 protein activates AKT signaling through mTORC2 and p38/PTEN, feeding into mTORC1-driven growth and GSK-3β/β-catenin-driven metastasis (PMID:28184024), operates in a positive-feedback loop with the E2F1 transcription factor that binds the OIP5 promoter (PMID:29547938), and engages NCK2 in a direct physical interaction (Co-IP, IP-MS, GST pulldown) that governs spermatogonial stem cell self-renewal via cyclin regulation (PMID:37292517). The antisense lncRNA OIP5-AS1 controls gene expression through several biochemically distinct routes: it binds and sequesters the RNA-binding protein HuR to modulate the stability of HuR target mRNAs, including reducing GAK mRNA stability to safeguard mitotic spindle integrity and mediating POLG mRNA decay under oxidative stress (PMID:28472763, PMID:26819413, PMID:33006594); it directs target RNA-directed decay of miR-7 to de-repress the fusogen MYMX during myogenesis (PMID:35736212); it recruits the PRC2 component EZH2 to promoters for epigenetic silencing (PMID:30972206); and it controls protein turnover by blocking Trim21-mediated ubiquitination of hnRNPA1 and by recruiting the E3 ligase ITCH to degrade TXNIP (PMID:37897508, PMID:38103409). In the heart, OIP5-AS1 binds AKAP1/calcineurin to prevent DRP1 dephosphorylation and excessive mitochondrial fission, and its loss exacerbates pressure-overload heart failure in a sex-specific manner (PMID:34142046, PMID:38745296). OIP5-AS1 stability is itself controlled by m6A-dependent IGF2BP3 binding and by SUMOylated IGF2BP2 (PMID:37897508, PMID:34345216).

Mechanistic history

Synthesis pass · year-by-year structured walk · 17 steps
  1. 2010 Medium

    Established that the OIP5 protein-coding gene is required for cancer cell survival, framing it as a candidate oncogene rather than a passenger.

    Evidence siRNA knockdown with flow cytometry and growth assays in colorectal and gastric cancer lines

    PMID:20510019

    Open questions at the time
    • No molecular partner or signaling pathway identified
    • Mechanism of apoptosis induction unresolved
  2. 2017 Medium

    Connected OIP5 protein to defined oncogenic signaling, showing it activates AKT via mTORC2 and p38/PTEN to drive growth and metastasis programs.

    Evidence Kinase profiling, shRNA, orthotopic mouse model and miRNA array in hepatocellular carcinoma

    PMID:28184024

    Open questions at the time
    • Direct biochemical link between OIP5 and the kinases not shown
    • How OIP5 activates these kinases mechanistically is unclear
  3. 2018 Medium

    Placed OIP5 protein in a transcriptional circuit by showing E2F1 drives its expression and OIP5 reciprocally stabilizes E2F1, creating a proliferative feedback loop.

    Evidence ChIP, luciferase, IP, shRNA and orthotopic tumor model in glioblastoma

    PMID:29547938

    Open questions at the time
    • Mechanism by which OIP5 stabilizes E2F1 not defined
    • Single tumor context
  4. 2023 High

    Identified the first validated direct protein partner of OIP5, NCK2, linking the interaction to stem cell self-renewal and cyclin control.

    Evidence Co-IP, IP-MS and GST pulldown with functional assays in human spermatogonial stem cells

    PMID:37292517

    Open questions at the time
    • Structural basis of the OIP5–NCK2 interaction unknown
    • How the interaction connects to the AKT/E2F1 axes not tested
  5. 2016 High

    Defined the antisense lncRNA OIP5-AS1 as an HuR-binding RNA that sequesters HuR from its target mRNAs, establishing a protein-sponge mode of action.

    Evidence MS2-tagging, RIP, RNA pulldown and HuR-target interaction assays

    PMID:26819413

    Open questions at the time
    • Full repertoire of affected HuR targets not enumerated
    • Stoichiometry of HuR sequestration unclear
  6. 2017 High

    Showed OIP5-AS1 controls mitotic fidelity by destabilizing GAK mRNA, with epistasis rescue placing it upstream of GAK in spindle regulation.

    Evidence RNA pulldown, proteomics, mRNA stability assay, double-knockdown rescue and spindle immunofluorescence

    PMID:28472763

    Open questions at the time
    • Whether GAK destabilization is HuR-dependent not directly tested
    • Other mitotic targets not excluded
  7. 2018 Medium

    Demonstrated nuclear OIP5-AS1 acts as a ceRNA for miR-186a-5p to upregulate ZEB1, supporting a cytoplasmic/nuclear miRNA-sponge function in cancer.

    Evidence Nuclear fractionation, RIP, dual luciferase and rescue assays in hepatoblastoma

    PMID:29475118

    Open questions at the time
    • ceRNA stoichiometry not quantified
    • Single cancer context
  8. 2019 Medium

    Established an epigenetic silencing mode in which OIP5-AS1 binds EZH2 and guides it to specific promoters (GSK-3β, NLRP6); nuclear localization corroborated the chromatin role.

    Evidence ChIP, RIP, nuclear/cytoplasmic fractionation and functional rescue in endothelial and gastric cancer cells

    PMID:30972206 PMID:31219209

    Open questions at the time
    • How OIP5-AS1 confers promoter specificity unknown
    • PRC2 recruitment generality across genes untested
  9. 2020 High

    Extended the HuR mechanism to mitochondrial maintenance, showing OIP5-AS1 and POLG mRNA share HuR as a scaffold so OIP5-AS1 promotes POLG decay and oxidative damage in lens cells, with TFAP2A as an upstream driver.

    Evidence RIP-qPCR of the ternary complex, ChIP, POLG rescue and ex vivo cataract model

    PMID:33006594

    Open questions at the time
    • Generality of POLG regulation in other tissues untested
    • Quantitative balance between HuR sequestration and scaffolding unclear
  10. 2020 Medium

    Showed OIP5-AS1 protects cardiomyocytes by sponging miR-29a to de-repress SIRT1 and activate AMPK/PGC1α, framing a cardioprotective ceRNA axis.

    Evidence Dual-luciferase, RIP, miR-29a and SIRT1-inhibitor rescue in rat MI/R and H9c2 models

    PMID:32468629

    Open questions at the time
    • Endogenous miR-29a sponging stoichiometry unquantified
    • Single signaling output measured
  11. 2021 High

    Defined how OIP5-AS1 levels are set post-transcriptionally, showing m6A-dependent IGF2BP3 binding and SUMOylated IGF2BP2 each stabilize the lncRNA.

    Evidence RNA pulldown, RIP, in vitro SUMOylation assay and xenografts in gastric cancer and glioma

    PMID:34345216 PMID:37897508

    Open questions at the time
    • Relative contribution of each stabilizer in vivo unclear
    • Whether the two pathways act in the same cells untested
  12. 2021 High

    Revealed OIP5-AS1 controls protein turnover, blocking Trim21-mediated ubiquitination of hnRNPA1 to sustain PKM2-driven glycolysis.

    Evidence RNA pulldown, RIP, ubiquitination assay and patient-derived xenografts in gastric cancer

    PMID:37897508

    Open questions at the time
    • Direct binding interface with hnRNPA1/Trim21 not mapped
    • Whether this is gastric-cancer specific unknown
  13. 2021 Medium

    Confirmed OIP5-AS1 supports proliferation through G2/M progression independent of apoptosis, and identified METTL14 as a negative upstream regulator feeding a miR-98/ADAMTS8/EGFR ceRNA axis.

    Evidence siRNA/ASO knockdown with cell-cycle analysis; RIP, pulldown, luciferase and xenografts in papillary thyroid cancer

    PMID:29277759 PMID:34131102

    Open questions at the time
    • Mechanistic link between G2/M control and named axes not unified
    • Single-context ceRNA validation
  14. 2022 High

    Demonstrated OIP5-AS1 actively degrades a specific miRNA via TDMD, driving miR-7 decay to de-repress the fusogen MYMX during myoblast fusion.

    Evidence qRT-PCR, oligonucleotide site blocker, MYMX luciferase reporter and myotube formation assays in human myogenesis

    PMID:35736212

    Open questions at the time
    • TDMD machinery components recruited by OIP5-AS1 not identified
    • Whether TDMD operates in non-muscle contexts untested
  15. 2021 High

    Established a physiological in vivo role for OIP5-AS1 in the heart, with global knockout worsening pressure-overload heart failure selectively in females via mitochondrial pathways.

    Evidence CRISPR knockout mice, transverse aortic constriction and RNA-seq

    PMID:34142046

    Open questions at the time
    • Molecular basis of sex specificity unresolved
    • Direct effector linking knockout to mitochondrial defects not defined
  16. 2023 High

    Showed OIP5-AS1 can act as a protein scaffold for an E3 ligase, recruiting ITCH to ubiquitinate and degrade TXNIP and thereby suppress neuronal pyroptosis after cerebral ischemia.

    Evidence RNA pulldown, RIP, Co-IP, ubiquitination assay and MCAO/R mouse and OGD/R cell models

    PMID:38103409

    Open questions at the time
    • Binding interfaces among OIP5-AS1, ITCH and TXNIP not mapped
    • Generality beyond the neuronal/exosome context untested
  17. 2024 High

    Defined a mitochondrial-fission control mechanism in which Oip5-as1 binds calcineurin to prevent DRP1 Ser637 dephosphorylation, limiting fission during ischemia/reperfusion injury.

    Evidence RNA pulldown, RIP, Co-IP, conditional CRISPR knockout and AAV9 overexpression with echocardiography

    PMID:38745296

    Open questions at the time
    • Role of AKAP1 binding versus calcineurin binding not fully separated
    • Direct effect on calcineurin catalytic activity not biochemically isolated

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved whether the OIP5 protein and its antisense lncRNA OIP5-AS1 are functionally coupled within the same cells, and how the many context-specific OIP5-AS1 mechanisms (HuR sponging, TDMD, EZH2 silencing, E3-ligase scaffolding, calcineurin binding) are selected in a given tissue.
  • No study integrates OIP5 protein and OIP5-AS1 functions in one system
  • Determinants of which OIP5-AS1 mechanism dominates per cell type unknown
  • No structural models for any OIP5/OIP5-AS1 interaction

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 5 GO:0060090 molecular adaptor activity 2 GO:0140098 catalytic activity, acting on RNA 2 GO:0140313 molecular sequestering activity 2 GO:0140110 transcription regulator activity 1
Localization
GO:0005634 nucleus 2 GO:0005739 mitochondrion 2
Pathway
R-HSA-162582 Signal Transduction 2 R-HSA-1640170 Cell Cycle 2 R-HSA-1643685 Disease 2 R-HSA-392499 Metabolism of proteins 2 R-HSA-4839726 Chromatin organization 2 R-HSA-8953854 Metabolism of RNA 2
Partners
AKAP1CALCINEURINEZH2HNRNPA1HURIGF2BP3ITCHNCK2

Evidence

Reading pass · 21 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2010 Knockdown of OIP5 (protein-coding gene) by siRNA resulted in growth inhibition of colorectal and gastric cancer cell lines with increased sub-G1 DNA content, suggesting OIP5 promotes cell survival and its loss induces apoptosis. siRNA knockdown, flow cytometry, growth inhibition assays BMB reports Medium 20510019
2017 OIP5 protein activates AKT signaling via both mTORC2 and p38/PTEN; AKT activation links to mTORC1 (cell growth) and GSK-3β/β-catenin (metastasis) signaling in hepatocellular carcinoma. miR-15b-5p targets OIP5 and inhibits these downstream oncogenic signals. Proteome kinase profiling, shRNA knockdown, orthotopic mouse model, miRNA PCR array Oncotarget Medium 28184024
2018 OIP5 protein is downstream of E2F1 transcription factor (E2F1 activates OIP5 expression by binding its promoter), and OIP5 in turn stabilizes and maintains E2F1 signaling in a positive feedback loop, promoting cell cycle progression in glioblastoma. Immunoprecipitation, chromatin immunoprecipitation (ChIP), luciferase assays, shRNA knockdown, orthotopic tumor model Neuro-oncology Medium 29547938
2018 OIP5 protein promotes growth, migration, and cisplatin resistance in bladder cancer cells; knockdown reduces colony formation, migration, and sensitizes cells to cisplatin. RNA-seq identified 38 DEGs including TOP2A, SPAG5, SKA1, EXO1, TK1 as downstream effectors. shRNA knockdown, scratch/transwell assays, cisplatin sensitivity assay, RNA-seq, in vivo xenograft Journal of Cancer Medium 30588253
2023 OIP5 protein interacts directly with NCK2 (as shown by Co-IP, IP-MS, and GST pulldown), and this interaction mediates human spermatogonial stem cell self-renewal and apoptosis through regulation of cell cycle proteins including cyclins A2, B1, D1, E1 and H. Co-immunoprecipitation (Co-IP), IP-MS (mass spectrometry), GST pulldown, siRNA knockdown, flow cytometry, whole-exome sequencing Research (Washington, D.C.) High 37292517
2017 lncRNA OIP5-AS1 (cyrano) suppresses cell proliferation by reducing GAK mRNA stability and GAK protein abundance; silencing OIP5-AS1 causes aberrant mitotic spindles (monopolar, multipolar, misaligned) that are partly rescued by simultaneous GAK silencing, placing OIP5-AS1 upstream of GAK in mitotic regulation. RNA pulldown of OIP5-AS1-bound mRNAs, proteomics of differentially expressed proteins upon OIP5-AS1 silencing, mRNA stability assay, siRNA double knockdown rescue, immunofluorescence of mitotic spindles Oncotarget High 28472763
2016 lncRNA OIP5-AS1 binds the RNA-binding protein HuR, which stabilizes OIP5-AS1; high OIP5-AS1 levels sequester HuR away from its target mRNAs (encoding proliferative proteins), acting as a competing endogenous RNA sponge for HuR. miR-424 competes with HuR for OIP5-AS1 binding. MS2-hairpin tagging of OIP5-AS1 to identify associated miRNAs, RIP, RNA pulldown, HuR-target mRNA interaction assays upon OIP5-AS1 modulation Nucleic acids research High 26819413
2022 During human myogenesis, lncRNA OIP5-AS1 binds miR-7 and induces its decay via target RNA-directed miRNA decay (TDMD); this OIP5-AS1-mediated miR-7 degradation de-represses the miR-7 target MYMX mRNA (encoding fusogenic protein myomixer), promoting myoblast fusion into myotubes. An oligonucleotide site blocker that prevents OIP5-AS1-directed miR-7 decay allowed miR-7 to accumulate and suppressed myotube formation. qRT-PCR of OIP5-AS1 and miR-7 levels during myogenesis, siRNA/antagonist functional assays, oligonucleotide site blocker, MYMX luciferase reporter, myotube formation assay Nucleic acids research High 35736212
2021 Loss of OIP5-AS1 (global CRISPR knockout) in female but not male mice leads to exacerbated heart failure following cardiac pressure overload (transverse aortic constriction); RNA-sequencing suggests OIP5-AS1 regulates pathways impacting mitochondrial function in a sex-specific manner. CRISPR knockout mice, transverse aortic constriction model, cardiac function assessment, RNA-sequencing iScience High 34142046
2024 lncRNA Oip5-as1 selectively interacts with AKAP1 and calcineurin (CaN) proteins; by binding CaN, Oip5-as1 inhibits CaN activation and thereby prevents DRP1 dephosphorylation at Ser637, blocking DRP1 translocation to mitochondria and reducing excessive mitochondrial fission during myocardial ischemia/reperfusion injury. RNA pulldown, RNA immunoprecipitation (RIP), co-immunoprecipitation (Co-IP), CRISPR/Cas9 conditional knockout mice, AAV9 overexpression, immunofluorescence, Western blot, echocardiography Cellular & molecular biology letters High 38745296
2024 Oip5-as1 delivery via lipid nanoparticles inhibits the p53 signaling pathway in cardiomyocytes, preserving mitochondrial function and reducing myocardial infarct size after ischemia/reperfusion injury; cardioprotective effects are abrogated by the p53 activator Nutlin-3a. Lipid nanoparticle delivery, H/R cell model and murine MI/R model, pharmacological rescue with Nutlin-3a, echocardiography ACS applied materials & interfaces Medium 39485791
2020 lncRNA OIP5-AS1 (Oip5-as1) acts as a competing endogenous RNA for miR-29a; by sponging miR-29a, OIP5-AS1 de-represses SIRT1 expression and activates the AMPK/PGC1α pathway, reducing mitochondria-mediated apoptosis during myocardial ischemia/reperfusion injury. Dual-luciferase reporter assay, RIP assay, miR-29a overexpression rescue, SIRT1 inhibitor (EX527) rescue, rat MI/R model and H9c2 OGD/R model Cell proliferation Medium 32468629
2019 lncRNA OIP5-AS1 binds EZH2 (a PRC2 component) and recruits it to the GSK-3β promoter region, leading to epigenetic silencing of GSK-3β expression; ChIP confirmed EZH2 direct binding to the GSK-3β promoter upon OIP5-AS1 overexpression, accelerating ox-LDL-mediated endothelial cell apoptosis. Chromatin immunoprecipitation (ChIP), OIP5-AS1 silencing/rescue experiments, Western blot American journal of translational research Medium 30972206
2019 lncRNA OIP5-AS1 binds EZH2 and epigenetically silences NLRP6 expression in gastric cancer cells; OIP5-AS1 was found to localize predominantly in the nucleus, consistent with its role in chromatin-based gene silencing. Nuclear/cytoplasmic fractionation (OIP5-AS1 nuclear localization), RIP assay (OIP5-AS1–EZH2 interaction), qRT-PCR and functional assays Journal of cellular biochemistry Medium 31219209
2020 lncRNA OIP5-AS1 located in the nucleus of hepatoblastoma cells targets miR-186a-5p (confirmed by RIP and dual luciferase assay) and thereby up-regulates ZEB1, an miR-186a-5p target gene, promoting EMT, proliferation and metastasis. Nuclear separation experiment (subcellular localization), RIP assay, dual luciferase assay, rescue assays Biomedicine & pharmacotherapy Medium 29475118
2021 N6-methyladenosine (m6A) modification on lncRNA OIP5-AS1 enables binding by IGF2BP3, which stabilizes OIP5-AS1 (RNA pulldown and RIP confirmed). OIP5-AS1 in turn prevents Trim21-mediated ubiquitination and degradation of hnRNPA1, stabilizing hnRNPA1 protein to promote PKM2 signaling and glycolysis in gastric cancer. RNA pulldown assay, RNA immunoprecipitation (RIP), ubiquitination assay, patient-derived xenograft models, Western blot Gastric cancer High 37897508
2021 lncRNA OIP5-AS1 positively regulates cell proliferation by promoting G2/M phase progression in HeLa cells; silencing OIP5-AS1 with siRNA or antisense oligonucleotides causes G2/M arrest without inducing apoptosis. siRNA and antisense oligonucleotide knockdown, cell cycle analysis by flow cytometry, apoptosis analysis Anticancer research Medium 29277759
2023 Exosome-derived lncRNA OIP5-AS1 (from M2 microglia) binds TXNIP protein and recruits the E3 ubiquitin ligase ITCH to promote TXNIP ubiquitination and proteasomal degradation, reducing TXNIP protein (but not mRNA) levels and inhibiting neuronal pyroptosis after cerebral ischemia/reperfusion injury. RNA pulldown, RNA immunoprecipitation (RIP), co-immunoprecipitation (Co-IP), ubiquitination assay, MCAO/R mouse model and OGD/R cell model International immunopharmacology High 38103409
2020 lncRNA OIP5-AS1 promotes cataract formation under oxidative stress by acting through HuR: HuR functions as a scaffold that carries both OIP5-AS1 and POLG mRNA, mediating decay of POLG mRNA; reduced POLG lowers mtDNA copy number and mitochondrial membrane potential, increasing ROS and apoptosis of lens epithelial cells. TFAP2A binds the OIP5-AS1 promoter and drives its expression. Ribonucleoprotein immunoprecipitation (RIP)-qPCR (OIP5-AS1–HuR–POLG mRNA complex), chromatin immunoprecipitation (ChIP)-qPCR (TFAP2A at OIP5-AS1 promoter), POLG overexpression rescue, JC-1 staining, flow cytometry, ex vivo cataract model Investigative ophthalmology & visual science High 33006594
2021 SUMOylation of IGF2BP2 at K497/K505/K509 (reducible by SENP1) increases IGF2BP2 protein stability by blocking ubiquitin-proteasome degradation; SUMOylated IGF2BP2 enhances stability of lncRNA OIP5-AS1, thereby increasing OIP5-AS1 sponging of miR-495-3p, de-repressing HIF1A and MMP14 and promoting vasculogenic mimicry in glioma. Ni2+-NTA agarose bead pulldown, Co-IP, in vitro SUMOylation assay, immunoprecipitation, immunofluorescence, RIP and luciferase reporter assays, nude mouse xenograft International journal of biological sciences High 34345216
2021 METTL14 suppresses PTC cell proliferation and migration by binding to and inhibiting lncRNA OIP5-AS1 expression (confirmed by RIP and RNA pulldown); OIP5-AS1 in turn acts as a sponge for miR-98 to up-regulate ADAMTS8, activating EGFR and MEK/ERK pathways. RIP assay, RNA pulldown assay, luciferase reporter assay, siRNA/overexpression functional assays, xenograft model Cell death & disease Medium 34131102

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2021 LncRNA OIP5-AS1 inhibits ferroptosis in prostate cancer with long-term cadmium exposure through miR-128-3p/SLC7A11 signaling. Ecotoxicology and environmental safety 153 34051661
2016 LncRNA OIP5-AS1/cyrano sponges RNA-binding protein HuR. Nucleic acids research 150 26819413
2017 LncRNA OIP5-AS1 loss-induced microRNA-410 accumulation regulates cell proliferation and apoptosis by targeting KLF10 via activating PTEN/PI3K/AKT pathway in multiple myeloma. Cell death & disease 135 28796257
2018 PIWIL3/OIP5-AS1/miR-367-3p/CEBPA feedback loop regulates the biological behavior of glioma cells. Theranostics 121 29464001
2018 LncRNA OIP5-AS1 regulates radioresistance by targeting DYRK1A through miR-369-3p in colorectal cancer cells. European journal of cell biology 97 29773344
2018 Long noncoding RNA OIP5-AS1 causes cisplatin resistance in osteosarcoma through inducing the LPAATβ/PI3K/AKT/mTOR signaling pathway by sponging the miR-340-5p. Journal of cellular biochemistry 97 30548308
2020 lncRNA Oip5-as1 attenuates myocardial ischaemia/reperfusion injury by sponging miR-29a to activate the SIRT1/AMPK/PGC1α pathway. Cell proliferation 85 32468629
2017 Long non-coding RNA OIP5-AS1 functions as an oncogene in lung adenocarcinoma through targeting miR-448/Bcl-2. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 78 29247949
2021 Cancer-associated fibroblasts-derived exosomes promote lung cancer progression by OIP5-AS1/ miR-142-5p/ PD-L1 axis. Molecular immunology 63 34653794
2021 Up-regulating lncRNA OIP5-AS1 protects neuron injury against cerebral hypoxia-ischemia induced inflammation and oxidative stress in microglia/macrophage through activating CTRP3 via sponging miR-186-5p. International immunopharmacology 60 33516048
2018 Fibronectin-1 modulated by the long noncoding RNA OIP5-AS1/miR-200b-3p axis contributes to doxorubicin resistance of osteosarcoma cells. Journal of cellular physiology 60 30204936
2018 Kockdown of OIP5-AS1 expression inhibits proliferation, metastasis and EMT progress in hepatoblastoma cells through up-regulating miR-186a-5p and down-regulating ZEB1. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 55 29475118
2021 Highly enriched exosomal lncRNA OIP5-AS1 regulates osteosarcoma tumor angiogenesis and autophagy through miR-153 and ATG5. American journal of translational research 53 34150009
2018 Long noncoding RNA OIP5-AS1 accelerates CDK14 expression to promote osteosarcoma tumorigenesis via targeting miR-223. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 53 30119217
2021 SUMOylation of IGF2BP2 promotes vasculogenic mimicry of glioma via regulating OIP5-AS1/miR-495-3p axis. International journal of biological sciences 49 34345216
2021 METTL14 promotes tumorigenesis by regulating lncRNA OIP5-AS1/miR-98/ADAMTS8 signaling in papillary thyroid cancer. Cell death & disease 48 34131102
2018 LncRNA OIP5-AS1 is overexpressed in undifferentiated oral tumors and integrated analysis identifies as a downstream effector of stemness-associated transcription factors. Scientific reports 48 29728583
2019 Long noncoding RNA OIP5-AS1 targets Wnt-7b to affect glioma progression via modulation of miR-410. Bioscience reports 46 30498093
2019 Long noncoding RNA OIP5-AS1 accelerates the ox-LDL mediated vascular endothelial cells apoptosis through targeting GSK-3β via recruiting EZH2. American journal of translational research 46 30972206
2010 OIP5 is a highly expressed potential therapeutic target for colorectal and gastric cancers. BMB reports 46 20510019
2019 Oncogenic KSHV-encoded interferon regulatory factor upregulates HMGB2 and CMPK1 expression to promote cell invasion by disrupting a complex lncRNA-OIP5-AS1/miR-218-5p network. PLoS pathogens 44 30699189
2017 Knockdown of linc-OIP5 inhibits proliferation and migration of glioma cells through down-regulation of YAP-NOTCH signaling pathway. Gene 43 28189759
2020 Downregulation of LncRNA OIP5-AS1 Induced by IL-1β Aggravates Osteoarthritis via Regulating miR-29b-3p/PGRN. Cartilage 42 32037864
2019 Long noncoding RNA OIP5-AS1 in cancer. Clinica chimica acta; international journal of clinical chemistry 41 31476304
2019 Long noncoding RNA OIP5-AS1 promotes the progression of oral squamous cell carcinoma via regulating miR-338-3p/NRP1 axis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 40 31369989
2020 LncRNA OIP5-AS1 promotes the malignancy of pancreatic ductal adenocarcinoma via regulating miR-429/FOXD1/ERK pathway. Cancer cell international 39 32669972
2017 OIP5, a target of miR-15b-5p, regulates hepatocellular carcinoma growth and metastasis through the AKT/mTORC1 and β-catenin signaling pathways. Oncotarget 39 28184024
2020 Long noncoding RNA OIP5-AS1 mediates resistance to doxorubicin by regulating miR-137-3p/PTN axis in osteosarcoma. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 37 32460190
2019 Long noncoding RNA OIP5-AS1 aggravates cell proliferation, migration in gastric cancer by epigenetically silencing NLRP6 expression via binding EZH2. Journal of cellular biochemistry 35 31219209
2020 LncRNA OIP5-AS1 Promotes Breast Cancer Progression by Regulating miR-216a-5p/GLO1. The Journal of surgical research 33 32916503
2019 LncRNA OIP5-AS1 Promotes the Proliferation of Hemangioma Vascular Endothelial Cells via Regulating miR-195-5p/NOB1 Axis. Frontiers in pharmacology 33 31068824
2023 N6-methyladenosine modification of OIP5-AS1 promotes glycolysis, tumorigenesis, and metastasis of gastric cancer by inhibiting Trim21-mediated hnRNPA1 ubiquitination and degradation. Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 32 37897508
2020 OIP5-AS1/miR-137/ZNF217 Axis Promotes Malignant Behaviors in Epithelial Ovarian Cancer. Cancer management and research 32 32801903
2017 LncRNA OIP5-AS1/cyrano suppresses GAK expression to control mitosis. Oncotarget 32 28472763
2006 Opa interacting protein 5 (OIP5) is a novel cancer-testis specific gene in gastric cancer. Annals of surgical oncology 32 17151793
2021 A review on the role of oncogenic lncRNA OIP5-AS1 in human malignancies. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 31 33601149
2019 Long noncoding RNA OIP5-AS1 acts as a competing endogenous RNA to promote glutamine catabolism and malignant melanoma growth by sponging miR-217. Journal of cellular physiology 31 30779126
2021 Long non-coding RNA OIP5-AS1 inhibition upregulates microRNA-129-5p to repress resistance to temozolomide in glioblastoma cells via downregulating IGF2BP2. Cell biology and toxicology 30 34132932
2020 Long non-coding RNA OIP5-AS1 promotes the growth of gastric cancer through the miR-367-3p/HMGA2 axis. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 30 31959478
2018 Cancer-testis specific gene OIP5: a downstream gene of E2F1 that promotes tumorigenesis and metastasis in glioblastoma by stabilizing E2F1 signaling. Neuro-oncology 30 29547938
2020 lncRNA OIP5-AS1 targets ROCK1 to promote cell proliferation and inhibit cell apoptosis through a mechanism involving miR-143-3p in cervical cancer. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 29 31939597
2020 Long non-coding RNA OIP5-AS1 suppresses multiple myeloma progression by sponging miR-27a-3p to activate TSC1 expression. Cancer cell international 29 32410883
2020 Long Non-Coding RNA OIP5-AS1 Knockdown Enhances CDDP Sensitivity in Osteosarcoma via miR-377-3p/FOSL2 Axis. OncoTargets and therapy 29 32440152
2020 Inhibitory role of long non-coding RNA OIP5-AS1 in rheumatoid arthritis progression through the microRNA-448-paraoxonase 1-toll-like receptor 3-nuclear factor κB axis. Experimental physiology 29 32770578
2018 The Long Noncoding RNA OIP5-AS1 Is Involved in the Regulation of Cell Proliferation. Anticancer research 29 29277759
2013 Expression analysis of four testis-specific genes AURKC, OIP5, PIWIL2 and TAF7L in acute myeloid leukemia: a gender-dependent expression pattern. Medical oncology (Northwood, London, England) 29 23292864
2021 Exosomal-mediated transfer of OIP5-AS1 enhanced cell chemoresistance to trastuzumab in breast cancer via up-regulating HMGB3 by sponging miR-381-3p. Open medicine (Warsaw, Poland) 28 33821219
2021 LncRNA OIP5-AS1 accelerates intervertebral disc degeneration by targeting miR-25-3p. Bioengineered 28 34872452
2020 LncRNA OIP5-AS1 facilitates ox-LDL-induced endothelial cell injury through the miR-98-5p/HMGB1 axis. Molecular and cellular biochemistry 28 32990894
2022 Long non-coding RNA OIP5-AS1 (Cyrano): A context-specific regulator of normal and disease processes. Clinical and translational medicine 27 35040588
2020 Long non-coding RNA OIP5-AS1 promotes pancreatic cancer cell growth through sponging miR-342-3p via AKT/ERK signaling pathway. Journal of physiology and biochemistry 27 32157498
2019 LncRNA OIP5-AS1 inhibits osteoblast differentiation of valve interstitial cells via miR-137/TWIST11 axis. Biochemical and biophysical research communications 27 30846207
2023 LncRNA OIP5-AS1/miR-410-3p/Wnt7b axis promotes the proliferation of rheumatoid arthritis fibroblast-like synoviocytes via regulating the Wnt/β-catenin pathway. Autoimmunity 26 36942896
2023 Exosomal OIP5-AS1 attenuates cerebral ischemia-reperfusion injury by negatively regulating TXNIP protein stability and inhibiting neuronal pyroptosis. International immunopharmacology 26 38103409
2020 LncRNA OIP5-AS1 promotes cell proliferation and migration and induces angiogenesis via regulating miR-3163/VEGFA in hepatocellular carcinoma. Cancer biology & therapy 26 32329664
2022 lncRNA OIP5-AS1 knockdown or miR-223 overexpression can alleviate LPS-induced ALI/ARDS by interfering with miR-223/NLRP3-mediated pyroptosis. The journal of gene medicine 25 34346534
2020 Linc-OIP5 in the breast cancer cells regulates angiogenesis of human umbilical vein endothelial cells through YAP1/Notch/NRP1 signaling circuit at a tumor microenvironment. Biological research 25 32046779
2024 lncRNA Oip5-as1 inhibits excessive mitochondrial fission in myocardial ischemia/reperfusion injury by modulating DRP1 phosphorylation. Cellular & molecular biology letters 24 38745296
2020 OIP5-AS1 modulates epigenetic regulator HDAC7 to enhance non-small cell lung cancer metastasis via miR-140-5p. Oncology letters 24 32774481
2022 The role of lncRNA OIP5-AS1 in cancer development and progression. Apoptosis : an international journal on programmed cell death 23 35316453
2021 lncRNA OIP5-AS1 Suppresses Cell Proliferation and Invasion of Endometrial Cancer by Regulating PTEN/AKT via Sponging miR-200c-3p. Journal of immunology research 23 34368370
2018 OIP5 Promotes Growth, Metastasis and Chemoresistance to Cisplatin in Bladder Cancer Cells. Journal of Cancer 23 30588253
2021 LncRNA OIP5-AS1 Promotes the Autophagy-Related Imatinib Resistance in Chronic Myeloid Leukemia Cells by Regulating miR-30e-5p/ATG12 Axis. Technology in cancer research & treatment 22 34723728
2020 LncRNA OIP5-AS1 interacts with miR-363-3p to contribute to hepatocellular carcinoma progression through up-regulation of SOX4. Gene therapy 22 32042127
2020 Long non coding RNA OIP5‑AS1 promotes metastasis of breast cancer via miR‑340‑5p/ZEB2 axis. Oncology reports 22 32945479
2020 Long Noncoding RNA OIP5-AS1 Promotes Cell Apoptosis and Cataract Formation by Blocking POLG Expression Under Oxidative Stress. Investigative ophthalmology & visual science 22 33006594
2019 Long non-coding RNA OIP5-AS1 promotes proliferation of gastric cancer cells by targeting miR-641. European review for medical and pharmacological sciences 22 31858545
2022 LncRNA OIP5-AS1-directed miR-7 degradation promotes MYMX production during human myogenesis. Nucleic acids research 21 35736212
2021 LncRNA OIP5-AS1 reduces renal epithelial cell apoptosis in cisplatin-induced AKI by regulating the miR-144-5p/PKM2 axis. Biomedical journal 21 34311128
2021 LncRNA OIP5-AS1 Regulates the Warburg Effect Through miR-124-5p/IDH2/HIF-1α Pathway in Cervical Cancer. Frontiers in cell and developmental biology 21 34513821
2020 Long non-coding RNA OIP5-AS1 serves as an oncogene in laryngeal squamous cell carcinoma by regulating miR-204-5p/ZEB1 axis. Naunyn-Schmiedeberg's archives of pharmacology 21 32009213
2020 Long non-coding RNA OIP5-AS1 plays an oncogenic role in ovarian cancer through targeting miR-324-3p/NFIB axis. European review for medical and pharmacological sciences 21 32706064
2020 LncRNA OIP5‑AS1 aggravates house dust mite‑induced inflammatory responses in human bronchial epithelial cells via the miR‑143‑3p/HMGB1 axis. Molecular medicine reports 21 33174035
2021 Long non-coding RNA OIP5-AS1 contributes to cisplatin resistance of oral squamous cell carcinoma through the miR-27b-3p/TRIM14 axis. Experimental and therapeutic medicine 20 33692839
2021 Loss of the long non-coding RNA OIP5-AS1 exacerbates heart failure in a sex-specific manner. iScience 20 34142046
2021 Molecular mechanism of miR-34b-5p and RNA binding protein HuR binding to lncRNA OIP5-AS1 in colon cancer cells. Cancer gene therapy 19 34021273
2021 Overexpressing long non-coding RNA OIP5-AS1 ameliorates sepsis-induced lung injury in a rat model via regulating the miR-128-3p/Sirtuin-1 pathway. Bioengineered 19 34592882
2020 LNCRNA OIP5-AS1 regulates oxidative low-density lipoprotein-mediated endothelial cell injury via miR-320a/LOX1 axis. Molecular and cellular biochemistry 19 32072428
2020 OIP5-AS1 promotes the progression of gastric cancer cells via the miR-153-3p/ZBTB2 axis. European review for medical and pharmacological sciences 19 32196594
2020 Long Noncoding RNA OIP5-AS1 Promotes the Progression of Liver Hepatocellular Carcinoma via Regulating the hsa-miR-26a-3p/EPHA2 Axis. Molecular therapy. Nucleic acids 19 32585630
2015 Cancer/Testis OIP5 and TAF7L Genes are Up-Regulated in Breast Cancer. Asian Pacific journal of cancer prevention : APJCP 19 26107214
2022 Tetramethylpyrazine and Astragaloside IV have synergistic effects against spinal cord injury-induced neuropathic pain via the OIP5-AS1/miR-34a/Sirt1/NF-κB axis. International immunopharmacology 18 36577153
2020 LncRNA OIP5-AS1 upregulates snail expression by sponging miR-34a to promote ovarian carcinoma cell invasion and migration. Biological research 18 33092644
2023 OIP5 Interacts with NCK2 to Mediate Human Spermatogonial Stem Cell Self-Renewal and Apoptosis through Cell Cyclins and Cycle Progression and Its Abnormality Is Correlated with Male Infertility. Research (Washington, D.C.) 17 37292517
2021 Long non‑coding RNA OIP5‑AS1 facilitates the progression of ovarian cancer via the miR‑128‑3p/CCNG1 axis. Molecular medicine reports 16 33760168
2020 OIP5-AS1 Attenuates Microangiopathy in Diabetic Mouse by Regulating miR-200b/ACE2. World neurosurgery 16 32200014
2020 Long Noncoding RNA OIP5-AS1 Contributes to the Progression of Atherosclerosis by Targeting miR-26a-5p Through the AKT/NF-κB Pathway. Journal of cardiovascular pharmacology 16 32833899
2019 Integrative analysis of OIP5-AS1/HUR1 to discover new potential biomarkers and therapeutic targets in multiple sclerosis. Journal of cellular physiology 16 30815864
2022 Long non-coding RNA OIP5-AS1 suppresses microRNA-92a to augment proliferation and metastasis of ovarian cancer cells through upregulating ITGA6. Journal of ovarian research 15 35168644
2020 LncRNA OIP5-AS1 facilitates gastric cancer cell growth by targeting the miR-422a/ANO1 axis. Acta biochimica et biophysica Sinica 15 32147682
2019 Linc-OIP5 loss regulates migration and invasion in MDA-MB-231 breast cancer cells by inhibiting YAP1/JAG1 signaling. Oncology letters 15 31897120
2024 Lipid Nanoparticle-Mediated Oip5-as1 Delivery Preserves Mitochondrial Function in Myocardial Ischemia/Reperfusion Injury by Inhibiting the p53 Pathway. ACS applied materials & interfaces 14 39485791
2022 OIP5-AS1 Inhibits Oxidative Stress and Inflammation in Ischemic Stroke Through miR-155-5p/IRF2BP2 Axis. Neurochemical research 14 36460840
2018 Expression Analysis of OIP5-AS1 in Non-Small Cell Lung Cancer. Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti 14 30541307
2021 Lnc-OIP5-AS1 exacerbates aorta wall injury during the development of aortic dissection through upregulating TUB via sponging miR-143-3p. Life sciences 13 33577845
2021 Long non-coding RNA OIP5-AS1 aggravates acute lung injury by promoting inflammation and cell apoptosis via regulating the miR-26a-5p/TLR4 axis. BMC pulmonary medicine 13 34261477
2021 OIP5-AS1 contributes to the development in endometrial carcinoma cells by targeting miR-152-3p to up-regulate SLC7A5. Cancer cell international 13 34419049
2020 LncRNA OIP5-AS1 induces epithelial-to-mesenchymal transition and renal fibrosis in diabetic nephropathy via binding to miR-30c-5p. Journal of biological regulators and homeostatic agents 13 32519534
2020 OIP5-AS1 contributes to tumorigenesis in hepatocellular carcinoma by miR-300/YY1-activated WNT pathway. Cancer cell international 13 32943988
2021 Long non-coding RNA OIP5-AS1 regulates smoke-related chronic obstructive pulmonary disease via targeting micro RNA -410-3p/IL-13. Bioengineered 12 34872453

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