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Showing NUP107 — NUP84 is a alias.

NUP107

Nuclear pore complex protein Nup107 · UniProt P57740

Length
925 aa
Mass
106.4 kDa
Annotated
2026-06-10
39 papers in source corpus 26 papers cited in narrative 26 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

NUP107 is a core scaffold nucleoporin that, with Nup160, Nup133, Nup96, Sec13, Seh1, Nup37, Nup43, and ELYS, forms the heptameric Nup107-160/Y-complex serving as a structural building block of the nuclear pore complex (NPC) (PMID:15146057, PMID:23954503). First identified as a non-FG NPC protein bearing a C-terminal leucine zipper and numerous kinase consensus sites (PMID:8021268), NUP107 functions as a keystone subunit: its depletion co-depletes Nup133 and blocks assembly of Nup358, Nup214, Nup153, and Tpr into the NPC (PMID:12552102). Structurally, NUP107 and Nup133 form an elongated tail-to-tail heterodimer in which NUP107 acts as the critical anchor positioning Nup133 at the NPC periphery (PMID:18570875, PMID:33247142), while the Nup84–Nup145C–Sec13 heterotrimer constitutes the edge element of a COPII-like Y-complex lattice (PMID:19855394, PMID:23954503). Interphasic NPC assembly is initiated by Nup153, which recruits the Nup107-160 complex to inner nuclear membrane assembly sites (PMID:26051542), and the complex's association with the NPC is modulated by cell-cycle-dependent phosphorylation clustered in N-terminal disordered regions (PMID:17360435). During mitosis the entire complex is targeted to kinetochores, where its recruitment depends on the Ndc80 complex and is required for chromosome congression, kinetochore-microtubule attachment, and kinetochore tension, and where it recruits Crm1 and RanGAP1-RanBP2 and supports proper Aurora B/CPC localization (PMID:17363900, PMID:19864462). Beyond NPC structure, the complex participates in transcription elongation (PMID:21478823), nucleotide excision repair and sister-chromatid recombination (PMID:30715474), and selective nucleocytoplasmic transport events including ATR-regulated Apaf-1 nuclear import for the intra-S checkpoint (PMID:25695197) and retention of pri-miRNA prior to processing during the maternal-to-zygotic transition (PMID:39791357). NUP107 mutations cause steroid-resistant nephrotic syndrome by disrupting the NUP107–NUP133 interface and NPC incorporation (PMID:26411495).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 1994 High

    Establishing NUP107 as a bona fide nucleoporin defined the molecular entity and hinted at regulatory and structural features before any complex was known.

    Evidence Molecular cloning, sequencing, and immunoelectron microscopy localization to the NPC

    PMID:8021268

    Open questions at the time
    • No interaction partners or complex membership defined
    • Functional role of the leucine zipper and kinase sites untested
  2. 1997 High

    Mapping NUP107 association with CAN/Nup214 on the cytoplasmic face localized the protein and assigned interaction-determining domains, the first step toward complex architecture.

    Evidence Reciprocal Co-IP under non-denaturing conditions plus mutagenesis mapping in human cells

    PMID:9166401

    Open questions at the time
    • Full Y-complex composition not yet known
    • Stoichiometry and direct vs indirect contacts unresolved
  3. 2003 High

    Defining NUP107 as a keystone nucleoporin showed that its loss collapses assembly of a specific subset of nucleoporins, establishing a hierarchy in NPC construction.

    Evidence siRNA depletion in HeLa cells with Western blot, RT-PCR, and immunofluorescence readouts of downstream nucleoporins

    PMID:12552102

    Open questions at the time
    • Mechanism of selective recruitment of downstream nups not defined
    • Order of assembly steps not resolved
  4. 2004 High

    Cataloguing the full vertebrate Nup107-160 complex and its mitotic kinetochore targeting expanded its role beyond interphase NPC structure into mitosis.

    Evidence Biochemical co-purification, GFP imaging, antibody immunofluorescence and RNAi in vertebrate cells; gene deletion, complex purification, and Ran genetic interaction in fission yeast

    PMID:15146057 PMID:15226438

    Open questions at the time
    • Kinetochore function of the complex not yet mechanistically dissected
    • How the complex links to mRNA export and Ran not resolved
  5. 2005 Medium

    Linking the yeast Nup84 subcomplex to transcriptional activation introduced a gene-regulatory function for the scaffold beyond transport.

    Evidence In vivo transcriptional activation assay with heterologous DNA-binding-domain fusions and genetic analysis

    PMID:15817685

    Open questions at the time
    • Mechanism not reconstituted in vitro
    • Relevance to metazoan NUP107 transcription untested
  6. 2007 High

    Showing kinetochore-localized Nup107-160 is recruited via Ndc80 and is required for congression, tension, and downstream Crm1/RanGAP1-RanBP2 recruitment defined its active mitotic role.

    Evidence Co-IP, siRNA depletion, immunofluorescence, live-cell imaging and kinetochore tension measurement; separately, in vivo 32P labeling and multi-stage MS mapped cell-cycle phosphorylation

    PMID:17360435 PMID:17363900

    Open questions at the time
    • Kinases responsible for the mapped phosphosites not identified
    • How phosphorylation controls NPC association mechanistically not shown
  7. 2008 High

    The Nup107-Nup133 crystal structure with structure-guided mutagenesis established NUP107 as the molecular anchor positioning Nup133 at the NPC.

    Evidence X-ray crystallography of the heterodimer plus structure-guided mutagenesis and NPC assembly assays

    PMID:18570875

    Open questions at the time
    • Higher-order lattice context not resolved here
    • Dynamics of the interface in vivo not addressed
  8. 2009 High

    Structural and functional work defined the Y-complex edge element and assigned Seh1 a role in CPC/Aurora B localization, deepening both architectural and mitotic understanding.

    Evidence X-ray crystallography of the Nup84-Nup145C-Sec13 heterotrimer; siRNA depletion, immunofluorescence, EM and live imaging for Seh1

    PMID:19855394 PMID:19864462

    Open questions at the time
    • Seh1 CPC role studied in a single lab
    • How edge element assembles into the full ring not shown
  9. 2012 High

    Reconstitution and a metazoan NUP107 null connected Y-complex architecture to kinetochore Nup133 recruitment and to spindle checkpoint MAD1, unifying structural and functional data across species.

    Evidence Protein reconstitution, EM and crosslinking MS (C. thermophilum, 2013); genetic null, immunofluorescence, Co-IP and epistasis in C. elegans (2012)

    PMID:22238360 PMID:23954503

    Open questions at the time
    • Direct vs indirect MAD1 interaction not fully resolved
    • Generality of kinetochore Nup133 dependence across cell types untested
  10. 2015 Medium

    Multiple 2015 studies resolved how the complex is recruited for interphasic assembly, defined a mobile intranuclear pool, linked NUP107 to Apaf-1-dependent DNA-damage checkpoint signaling, and established a disease mechanism.

    Evidence Nup153 recruitment and membrane-binding assays; FRAP of GLFG-body Y-complex pool; Apaf-1 binding/domain mapping and checkpoint assays; in vitro binding/incorporation assays of nephrotic syndrome mutants with zebrafish knockdown

    PMID:25695197 PMID:25904327 PMID:26051542 PMID:26411495

    Open questions at the time
    • Function of the mobile intranuclear Y-complex pool unclear
    • Apaf-1 import and disease findings each from single labs without independent replication
  11. 2019 High

    Asymmetric localization data and DNA repair assays refined where NUP107 sits within the NPC and broadened its genome-maintenance roles.

    Evidence ImmunoEM, fluorescence microscopy and domain-fusion in fission yeast; UV sensitivity, NER, sister-chromatid recombination and fork progression assays in budding yeast

    PMID:30715474 PMID:31170156

    Open questions at the time
    • Whether asymmetric positioning holds in metazoa not tested
    • Direct role of NUP107 protein in NER vs indirect via NPC tethering not separated
  12. 2020 High

    Full-length Nup84-Nup133 structures revealed conformational flexibility and confirmed an ALPS lipid-sensing motif, connecting the scaffold to membrane curvature recognition.

    Evidence Nanobody-bound X-ray crystallography plus liposome interaction assays

    PMID:33247142

    Open questions at the time
    • Functional consequence of flexibility in assembled NPCs not shown
    • ALPS motif role in vivo not directly tested
  13. 2025 Medium

    Developmental and disease studies extended NUP107 function to pri-miRNA retention during the maternal-to-zygotic transition, EcR signaling in metamorphosis, and stress-granule association in C9orf72-ALS.

    Evidence Morpholino depletion with RNA-seq and fractionation in Xenopus; RNAi and genetic epistasis in Drosophila; Co-IP and co-localization in iPSC motor neurons with C. elegans rescue

    PMID:39791357 PMID:40891053 PMID:41805630

    Open questions at the time
    • Mechanism of selective pri-miRNA retention unresolved
    • Each developmental/disease link from a single lab
    • Whether ALS phenotypes reflect direct NUP107 aggregation or transport failure unclear

Open questions

Synthesis pass · forward-looking unresolved questions
  • How NUP107 phosphorylation, conformational flexibility, and membrane-sensing are coordinated to control NPC assembly versus its many off-pore functions remains unresolved.
  • Kinases and signals coupling phosphorylation to NPC association unidentified
  • Mechanistic basis for selective transport (Apaf-1, pri-miRNA, EcR) not unified
  • Tissue-specificity of nephrotic-syndrome disease phenotype unexplained

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 3 GO:0060090 molecular adaptor activity 3 GO:0008289 lipid binding 1
Localization
GO:0005634 nucleus 2 GO:0005635 nuclear envelope 2 GO:0005694 chromosome 2
Pathway
R-HSA-1640170 Cell Cycle 3 R-HSA-74160 Gene expression (Transcription) 3 R-HSA-9609507 Protein localization 3 R-HSA-1852241 Organelle biogenesis and maintenance 2 R-HSA-8953854 Metabolism of RNA 2 R-HSA-73894 DNA Repair 1
Partners
ELYSNUP133NUP153NUP214NUP37NUP96SEC13SEH1
Complex memberships
Nup107-160 / Y-complexkinetochorenuclear pore complex (NPC)

Evidence

Reading pass · 26 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1994 NUP107 was identified as a novel nuclear pore complex protein containing a leucine zipper in its carboxyl-terminal region and numerous kinase consensus sites, but lacking FG repeats; it was localized to the NPC by immunoelectron microscopy. Molecular cloning, sequencing, immunoelectron microscopy, biochemical fractionation The Journal of biological chemistry High 8021268
1997 Human Nup84 (NUP107) is tightly associated with CAN/Nup214 on the cytoplasmic face of the NPC; the NH2-terminal region of Nup84 contains the interaction site with CAN/Nup214, while the C-terminal putative coiled-coil domain is required for association with the cytoplasmic face of the NPC. Immunoprecipitation under nondenaturing conditions, mutagenesis, expression studies, cytoplasmic face localization determination The Journal of cell biology High 9166401
2003 Depletion of Nup107 by siRNA caused co-depletion of Nup133 (but not Nup96 or Sec13) and prevented assembly of Nup358, Nup214, Nup153, and Tpr into the NPC, establishing Nup107 as a keystone nucleoporin required for assembly of a subset of nucleoporins into the NPC. siRNA knockdown in HeLa cells, Western blot, RT-PCR, immunofluorescence Proceedings of the National Academy of Sciences of the United States of America High 12552102
2004 The Nup107-160 complex in vertebrates includes three additional WD-repeat nucleoporins (Nup37, Nup43, and Seh1/Sec13), and the entire complex is targeted to kinetochores from prophase to anaphase of mitosis. Biochemical co-purification, GFP-tagged nucleoporin imaging, specific antibody immunofluorescence, RNAi Molecular biology of the cell High 15146057
2004 The fission yeast Nup107-120 complex (ortholog of the vertebrate Nup107-160 complex) is required for mRNA export, nuclear pore distribution, and proper cell division; it functionally interacts with the small GTPase Ran/Spi1, as overexpression of a nonfunctional Ran allele is specifically toxic in nup120 and nup133b deletion mutants. Gene deletion, biochemical co-purification, nuclear envelope localization, genetic epistasis/synthetic lethality, mRNA export assay Molecular and cellular biology High 15226438
2005 The yeast Nup84 subcomplex mediates Rap1/Gcr1/Gcr2 transcriptional activation ('reverse recruitment'); Nup84 and associated subcomplex components can activate transcription themselves when fused to a heterologous DNA-binding domain, and Gcr1/Gcr2 bridge the NPC to the transcriptional machinery. In vivo transcriptional activation assay with heterologous DNA-binding domain fusions, genetic analysis Proceedings of the National Academy of Sciences of the United States of America Medium 15817685
2007 The Nup107-160 complex interacts with CENP-F and its kinetochore recruitment mainly depends on the Ndc80 complex; depletion of the Nup107-160 complex from kinetochores causes mitotic delay, impaired chromosome congression, reduced kinetochore tension, and kinetochore-microtubule attachment defects; the Nup107-160 complex at kinetochores is required for recruitment of Crm1 and RanGAP1-RanBP2 to kinetochores. Co-immunoprecipitation, siRNA depletion, immunofluorescence, live-cell imaging, kinetochore tension measurement The EMBO journal High 17363900
2007 Nup107, Nup96, Nup133, and Nup160 subunits of the Nup107-160 complex are phosphorylated in a cell-cycle-dependent manner; phosphorylation sites cluster at the N-terminal disordered regions; the Nup107-160 subcomplex remains stable throughout the cell cycle, indicating phosphorylation regulates its association with the NPC rather than intra-complex interactions. In vivo 32P labeling, multi-stage mass spectrometry (MS/MS2/MS3), stable isotope labeling, cell-cycle synchronization Proceedings of the National Academy of Sciences of the United States of America High 17360435
2008 Crystal structure of the Nup107-Nup133 heterodimer reveals elongated structures interacting via a compact interface in tail-to-tail fashion; structure-guided mutagenesis shows Nup107 is the critical anchor for Nup133 to the NPC, positioning Nup133 at the NPC periphery. X-ray crystallography, structure-guided mutagenesis, NPC assembly assays Molecular cell High 18570875
2009 The Nup84-Nup145C-Sec13 heterotrimer forms the edge element of the NPC Y-complex lattice; the ACE1 heterotypic interaction between Nup84 and Nup145C is analogous to the homotypic ACE1 interaction of Sec31 in COPII lattice, supporting a lattice model for NPC scaffold architecture. X-ray crystallography of the 134-kDa heterotrimeric complex Nature structural & molecular biology High 19855394
2009 Seh1, a component of the Nup107-160 complex, regulates centromeric localization of Aurora B and other chromosome passenger complex (CPC) proteins; Seh1 depletion causes impaired Aurora B localization, biorientation defects, and spindle midzone/midbody organization defects, while microtubule-kinetochore attachments remain intact. siRNA depletion, immunofluorescence, electron microscopy, live-cell imaging Molecular biology of the cell Medium 19864462
2010 Depletion of Nup107 by siRNA in senescent human diploid fibroblasts prevents effective nuclear translocation of phosphorylated ERK following EGF stimulation and decreases c-Fos expression, implicating Nup107 in nuclear trafficking of signal molecules. siRNA knockdown, immunofluorescence for phospho-ERK, Western blot for c-Fos Biochemical and biophysical research communications Medium 20833136
2011 SENP2 interacts with the Nup107-160 nucleoporin subcomplex through a distinct N-terminal targeting element; disruption of this interaction (along with karyopherin-mediated tethering) enhances SENP2 substrate accessibility, suggesting NPC-tethering regulates SUMO pathway activity. FRAP, Co-IP/pulldown, deletion/mutant constructs, NPC localization assays in human cells Molecular biology of the cell Medium 22031293
2011 The yeast Nup84 complex is required for efficient transcription elongation, as demonstrated by a G-less-based run-on assay and RNA polymerase II chromatin immunoprecipitation. G-less-based run-on (GLRO) assay, RNA polymerase II ChIP, mutant analysis The EMBO journal Medium 21478823
2012 In C. elegans, NUP107/NPP-5 is essential for proper kinetochore localization of NUP133/NPP-15 but not NUP96/NPP-10C or ELYS/MEL-28; NUP107 physically and genetically interacts with spindle assembly checkpoint protein MAD1/MDF-1, and is required for MAD1's nuclear envelope accumulation. Genetic disruption (null mutant), immunofluorescence, Co-immunoprecipitation, genetic epistasis, nuclear protein import assay Molecular biology of the cell High 22238360
2013 Reconstituted octameric Nup84 complex from Chaetomium thermophilum (carrying Nup37 and Elys) forms a dimer with side-to-side arrangement; crosslinking mass spectrometry mapped key protein interfaces within the Y-complex; Elys binds cooperatively requiring both Nup37 and Nup120. Protein reconstitution, electron microscopy, crosslinking mass spectrometry Structure (London, England : 1993) High 23954503
2015 Nup153 recruits the Nup107-160 complex to assembly sites at the inner nuclear membrane for interphasic (but not mitotic exit) NPC assembly; Nup153 binds directly to the inner nuclear membrane via an N-terminal amphipathic helix, and transportin and Ran regulate this membrane interaction. siRNA depletion, immunofluorescence, in vitro membrane binding assay, mutational analysis Developmental cell High 26051542
2015 Three of four NUP107 disease mutations detected in patients with steroid-resistant nephrotic syndrome impair NUP107 binding to NUP133 and NUP107 incorporation into NPCs in vitro, establishing that loss of NUP107–NUP133 interaction is a molecular mechanism underlying the disease. In vitro binding assay, NPC incorporation assay with mutant proteins, zebrafish morpholino knockdown American journal of human genetics Medium 26411495
2015 A fraction of Nup107 (as part of the Y-complex) localizes within intranuclear GLFG bodies along with Nup98 and Elys; this intranuclear pool of the Y-complex is dynamically mobile (shown by FRAP), unlike the stable NPC-associated pool; Y-complex recruitment into GLFG bodies requires the C-terminal domain of Nup98. Immunofluorescence, co-localization, FRAP, GFP-tagging, siRNA depletion Molecular biology of the cell Medium 25904327
2015 Nup107 directly binds Apaf-1 via the CED-4 domain of Apaf-1 and the central domain of Nup107 in an ATR-regulated, phosphorylation-dependent manner; this interaction is required for Apaf-1 nuclear import upon DNA damage, which in turn is required for Chk-1 activation and intra-S phase checkpoint. Co-immunoprecipitation, direct binding assay, dominant-negative interference, siRNA, cell cycle checkpoint assay Cell cycle (Georgetown, Tex.) Medium 25695197
2019 In fission yeast, the Nup107-160 complex components show asymmetrical localization: spNup132 and spNup107 localize only to the nuclear side, while spNup131, spNup120, spNup85, spNup96, spNup37, spEly5, and spSeh1 localize only to the cytoplasmic side; fusion of spNup96 with spNup107 caused cytoplasmic mislocalization of spNup107 and led to cell cycle defects similar to spNup132 deletion. Immunoelectron microscopy, fluorescence microscopy, domain-fusion experiments, cell cycle analysis PLoS genetics High 31170156
2019 The yeast Nup84 complex is required for efficient nucleotide excision repair (NER) of UV-induced lesions, repair of replication-born DSBs by sister chromatid recombination (SCR), and prevention of chromosomal rearrangements; nup84Δ cells show exacerbated UV sensitivity in S phase and delayed replication fork progression. UV sensitivity assays, NER assays, sister chromatid recombination assays, replication fork progression analysis Nucleic acids research Medium 30715474
2020 Crystal structures of the full-length yeast Nup84-Nup133CTD complex and the Nup133NTD (bound to nanobodies) reveal high flexibility of this dimeric unit; the Nup133 NTD contains a structurally conserved amphipathic lipid packing sensor (ALPS) motif confirmed by liposome interaction studies. X-ray crystallography (nanobody-bound structures), liposome interaction assay Nature communications High 33247142
2025 In C9orf72-ALS motor neurons, G3BP1 (a core stress granule component) exhibits enhanced interaction with Nup107, and Nup107 colocalizes with and aggregates in stress granules; knockdown of the C. elegans Nup107 ortholog (npp-5) alleviates ALS-associated phenotypes including reduced lifespan and impaired motility. Co-immunoprecipitation in iPSC-derived motor neurons, immunofluorescence co-localization, C. elegans npp-5 RNAi knockdown with lifespan/motility assays FEBS letters Medium 40891053
2025 In Xenopus, Nup107 is required to prevent premature nuclear export of pri-miR427 before processing; depletion of Nup107 leads to reduced mature miR427 production, stabilization of maternal transcripts including REST, and disruption of the maternal-to-zygotic transition with expansion of ectoderm at the expense of endoderm and mesoderm. Morpholino depletion in Xenopus embryos, RNA-sequencing time course, nuclear/cytoplasmic fractionation, miRNA quantification, in situ hybridization Development (Cambridge, England) Medium 39791357
2026 In Drosophila, Nup107 is required for nuclear translocation and transcriptional activation by the ecdysone receptor (EcR) and for transcription of Halloween genes (ecdysone biosynthesis genes); Nup107 functions epistatically downstream of the Torso receptor tyrosine kinase/Ras/MAPK pathway to activate EcR signaling during metamorphosis. RNAi knockdown, genetic epistasis (overexpression of torso/ras in Nup107-depleted background), EcR nuclear localization assay, gene expression analysis eLife Medium 41805630

Source papers

Stage 0 corpus · 39 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2004 The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis. Molecular biology of the cell 224 15146057
2007 The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions. The EMBO journal 172 17363900
2003 Depletion of a single nucleoporin, Nup107, prevents the assembly of a subset of nucleoporins into the nuclear pore complex. Proceedings of the National Academy of Sciences of the United States of America 130 12552102
2015 Nup153 Recruits the Nup107-160 Complex to the Inner Nuclear Membrane for Interphasic Nuclear Pore Complex Assembly. Developmental cell 117 26051542
2005 Reverse recruitment: the Nup84 nuclear pore subcomplex mediates Rap1/Gcr1/Gcr2 transcriptional activation. Proceedings of the National Academy of Sciences of the United States of America 114 15817685
2015 Biallelic Mutations in Nuclear Pore Complex Subunit NUP107 Cause Early-Childhood-Onset Steroid-Resistant Nephrotic Syndrome. American journal of human genetics 100 26411495
1997 Nup84, a novel nucleoporin that is associated with CAN/Nup214 on the cytoplasmic face of the nuclear pore complex. The Journal of cell biology 89 9166401
2008 Structural and functional studies of Nup107/Nup133 interaction and its implications for the architecture of the nuclear pore complex. Molecular cell 84 18570875
2007 Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160 subcomplex. Proceedings of the National Academy of Sciences of the United States of America 83 17360435
2017 Homozygous mutation in NUP107 leads to microcephaly with steroid-resistant nephrotic condition similar to Galloway-Mowat syndrome. Journal of medical genetics 73 28280135
2004 The fission yeast Nup107-120 complex functionally interacts with the small GTPase Ran/Spi1 and is required for mRNA export, nuclear pore distribution, and proper cell division. Molecular and cellular biology 70 15226438
2009 The Nup107-160 nucleoporin complex promotes mitotic events via control of the localization state of the chromosome passenger complex. Molecular biology of the cell 69 19864462
2009 Molecular architecture of the Nup84-Nup145C-Sec13 edge element in the nuclear pore complex lattice. Nature structural & molecular biology 65 19855394
2011 The SUMO-specific isopeptidase SENP2 associates dynamically with nuclear pore complexes through interactions with karyopherins and the Nup107-160 nucleoporin subcomplex. Molecular biology of the cell 51 22031293
2011 A novel assay identifies transcript elongation roles for the Nup84 complex and RNA processing factors. The EMBO journal 49 21478823
2012 Dissection of the NUP107 nuclear pore subcomplex reveals a novel interaction with spindle assembly checkpoint protein MAD1 in Caenorhabditis elegans. Molecular biology of the cell 45 22238360
2013 Protein interfaces of the conserved Nup84 complex from Chaetomium thermophilum shown by crosslinking mass spectrometry and electron microscopy. Structure (London, England : 1993) 42 23954503
2015 Intranuclear dynamics of the Nup107-160 complex. Molecular biology of the cell 36 25904327
1994 Nup107 is a novel nuclear pore complex protein that contains a leucine zipper. The Journal of biological chemistry 35 8021268
2020 Yeast Nup84-Nup133 complex structure details flexibility and reveals conservation of the membrane anchoring ALPS motif. Nature communications 33 33247142
2017 NUP107 mutations in children with steroid-resistant nephrotic syndrome. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 30 27190346
2012 Dissecting the NUP107 complex: multiple components and even more functions. Nucleus (Austin, Tex.) 27 22713280
2019 Asymmetrical localization of Nup107-160 subcomplex components within the nuclear pore complex in fission yeast. PLoS genetics 26 31170156
2015 DNA damage-induced nuclear translocation of Apaf-1 is mediated by nucleoporin Nup107. Cell cycle (Georgetown, Tex.) 26 25695197
2012 Loss of zygotic NUP107 protein causes missing of pharyngeal skeleton and other tissue defects with impaired nuclear pore function in zebrafish embryos. The Journal of biological chemistry 23 22965233
2019 The Nup84 complex coordinates the DNA damage response to warrant genome integrity. Nucleic acids research 22 30715474
2018 Functional study of a novel missense single-nucleotide variant of NUP107 in two daughters of Mexican origin with premature ovarian insufficiency. Molecular genetics & genomic medicine 22 29363275
2010 Reduction of Nup107 attenuates the growth factor signaling in the senescent cells. Biochemical and biophysical research communications 16 20833136
2014 Analysis of the Lotus japonicus nuclear pore NUP107-160 subcomplex reveals pronounced structural plasticity and functional redundancy. Frontiers in plant science 13 24478780
2010 Characterization of the membrane-coating Nup84 complex: paradigm for the nuclear pore complex structure. Nucleus (Austin, Tex.) 11 21326946
2010 Depletion of a single nucleoporin, Nup107, induces apoptosis in eukaryotic cells. Molecular and cellular biochemistry 10 20490895
2001 Disruption and functional analysis of six ORFs of chromosome IV: YDL103c (QRI1), YDL105w (QRI2), YDL112w (TRM3), YDL113c, YDL116w (NUP84) and YDL167c (NRP1). Yeast (Chichester, England) 9 11180460
2024 Mutations in the NUP93, NUP107 and NUP160 genes cause steroid-resistant nephrotic syndrome in Chinese children. Italian journal of pediatrics 7 38650033
2007 Purification, crystallization and preliminary X-ray analysis of a Nup107-Nup133 heterodimeric nucleoporin complex. Acta crystallographica. Section F, Structural biology and crystallization communications 6 17768364
2025 C9orf72 ALS-causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules. FEBS letters 3 40891053
2020 Nup84 persists within the nuclear envelope of the rice blast fungus, Magnaporthe oryzae, during mitosis. Fungal genetics and biology : FG & B 3 32980454
2025 Nup107 contributes to the maternal-to-zygotic transition by preventing the premature nuclear export of pri-miR427. Development (Cambridge, England) 2 39791357
2026 Nup107 is a crucial regulator of torso-mediated metamorphic transition in Drosophila melanogaster. eLife 0 41805630
2024 Recurrent Increased Nuchal Translucency Led to the Identification of Novel NUP107 Variants. American journal of medical genetics. Part A 0 39473271

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