Affinage

Showing SEH1L — SEH1 is a alias.

SEH1L

Nucleoporin SEH1 · UniProt Q96EE3

Length
360 aa
Mass
39.6 kDa
Annotated
2026-06-10
49 papers in source corpus 22 papers cited in narrative 22 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SEH1L (Seh1) is a WD40 β-propeller protein that functions as a shared structural subunit of two distinct β-propeller-based assemblies — the Nup107-160 nuclear pore subcomplex and the GATOR2 complex — and additionally carries out NPC-independent chromatin functions (PMID:15146057, PMID:23723238, PMID:38272027). In GATOR2, Seh1L assembles with Mios, WDR24, WDR59, and Sec13 to positively regulate mTORC1 signaling, acting upstream of and antagonizing the GATOR1 GAP toward Rag GTPases in the amino acid-sensing pathway (PMID:23723238, PMID:25512509). Cryo-EM defines GATOR2 as a 1.1 MDa two-fold-symmetric cage in which SEH1L and SEC13 integrate via β-propeller blade donation to stabilize the scaffold, and the WDR24-Seh1L subcomplex serves as the direct docking site for the leucine sensor Sestrin2, which induces conformational changes that gate signaling (PMID:35831510, PMID:40742811). In the nuclear pore, Seh1 forms the short arm of the Y-shaped Nup84/Nup107-160 complex through an ancestral coatomer element (ACE1) interface with Nup85, and is required to target this complex to kinetochores during mitosis (PMID:19641729, PMID:15146057, PMID:17363900). Loss of Seh1 strips the Nup107-160 complex from kinetochores and impairs centromeric recruitment of Aurora B/the chromosomal passenger complex, causing biorientation defects, reduced kinetochore tension, and chromosome missegregation (PMID:17363900, PMID:19864462, PMID:29618633). Beyond the pore, Seh1 cooperates with the NuRD complex at the nuclear periphery to repress p21 in neural stem cells, and stabilizes the SETDB1-KAP1 interaction to maintain genome stability in Schwann cells — chromatin-associated roles independent of nucleocytoplasmic transport (PMID:38272027, PMID:37453065).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 2004 High

    Established Seh1 as a constituent of the vertebrate Nup107-160 nuclear pore subcomplex and showed it shares the loss-of-function phenotypes of its partners, defining its baseline structural role at the NPC.

    Evidence Co-IP, RNAi knockdown, and live-cell imaging in vertebrate cells; deletion/genetic analysis of the conserved Nup107-120 complex in S. pombe

    PMID:15146057 PMID:15226438

    Open questions at the time
    • Did not resolve the structural interface tethering Seh1 within the complex
    • Mitotic kinetochore function not yet mechanistically dissected
  2. 2007 High

    Demonstrated that Seh1 specifically anchors the Nup107-160 complex at kinetochores and that this is required to recruit downstream Crm1 and RanGAP1-RanBP2, linking the nucleoporin to mitotic fidelity.

    Evidence siRNA depletion with immunofluorescence, live-cell imaging, and mitotic phenotype analysis

    PMID:17363900

    Open questions at the time
    • How Seh1 loss selectively removes the complex from kinetochores not defined
    • Did not yet connect to Aurora B/CPC
  3. 2009 High

    Identified the mechanistic consequence of Seh1 loss as failure to load Aurora B/the CPC at centromeres, explaining biorientation and segregation defects independent of microtubule attachment integrity.

    Evidence siRNA knockdown with immunofluorescence, electron microscopy, and live-cell imaging; crystal structure of the Nup85-Seh1 ACE1 interface with mutagenesis

    PMID:19641729 PMID:19864462

    Open questions at the time
    • Molecular link between Nup107-160 presence and CPC recruitment unresolved
    • ACE1 functional sites verified by analogy rather than full reconstitution
  4. 2013 High

    Placed Seh1L within the GATOR2 complex as a positive regulator of mTORC1 acting upstream of GATOR1, defining a second, transport-independent macromolecular role.

    Evidence siRNA knockdown, reciprocal co-IP, epistasis, and phospho-S6K mTORC1 activity assays in human cells; genetic epistasis and TORC1 assays in yeast SEACAT/SEACIT

    PMID:23723238 PMID:23974112

    Open questions at the time
    • Structural basis of GATOR2 assembly not yet known
    • How GATOR2 antagonizes GATOR1 GAP activity mechanistically unclear
  5. 2011 High

    Showed across yeast and Drosophila that Seh1 stabilizes its GATOR2/SEA partners (e.g. Mio) and that the complex resembles membrane-coating assemblies, tying its β-propeller architecture to nutrient and trafficking functions.

    Evidence Affinity purification/MS, computational structure prediction, and live imaging of the yeast SEA complex; Drosophila null allele with Co-IP and protein stability assays

    PMID:21454883 PMID:21521741

    Open questions at the time
    • Direct structural demonstration of coat-like architecture not yet achieved
    • Stoichiometry of the assembled complex undefined
  6. 2014 High

    Confirmed in a whole-organism context that Seh1/GATOR2 opposes GATOR1 to permit TORC1 activity, with developmental consequences for oocyte growth.

    Evidence Drosophila null alleles, epistasis, rapamycin treatment, and TORC1 activity assays

    PMID:25512509

    Open questions at the time
    • Mammalian developmental relevance not addressed in this work
  7. 2016 Medium

    Revealed a TORC1-independent function of Seh1/GATOR2 in lysosome function and autophagic flux, expanding its role beyond the canonical Rag GTPase axis.

    Evidence Drosophila null alleles, epistasis with GATOR1, lysosome acidification and autophagy flux assays

    PMID:27166823

    Open questions at the time
    • Molecular mechanism of the lysosomal role undefined
    • Single-organism study
  8. 2018 High

    Distinguished Seh1's two roles on mitotic chromosomes — dispensable for Nup107 complex but essential for GATOR2 and Nup153 association and CPC loading — and uncovered Aurora B phosphorylation of a SEH1 PP1-binding motif as a regulatory switch.

    Evidence Auxin-inducible degron with quantitative chromosome proteomics and immunofluorescence; phospho-specific antibody, MS, and Aurora B kinase assays

    PMID:29618633 PMID:29764992

    Open questions at the time
    • Functional consequence of PP1-motif phosphorylation on segregation not fully resolved
    • How GATOR2 is recruited to chromosomes unclear
  9. 2022 High

    Provided the structural basis of GATOR2, showing SEH1L integrates via β-propeller blade donation to stabilize a cage-like scaffold that positions WD40 dimers for sensor and GATOR1 contacts.

    Evidence Cryo-EM structure of the human 1.1 MDa GATOR2 complex with functional validation of subunit integration

    PMID:35831510

    Open questions at the time
    • How sensor binding propagates to GATOR1 inhibition not resolved in this state
    • Dynamics of the apo vs sensor-bound states not captured
  10. 2023 Medium

    Uncovered NPC-independent chromatin functions of Seh1, including stabilizing the SETDB1-KAP1 silencing axis to maintain genome stability and prevent necroptosis in Schwann cells.

    Evidence Conditional knockout, Co-IP of SETDB1/KAP1, transcriptome analysis, and necroptosis assays; transcriptomic gene-regulation analysis during neuroectodermal differentiation

    PMID:37305998 PMID:37453065

    Open questions at the time
    • Direct biochemical role of Seh1 in bridging SETDB1-KAP1 not structurally defined
    • Gene-regulation findings are largely correlative
  11. 2024 Medium

    Defined a NuRD-dependent transcriptional repression role for Seh1 at the nuclear periphery controlling p21 and neurogenesis, separating this chromatin function from nucleocytoplasmic transport.

    Evidence Conditional knockout, transcriptome analysis, and p21 knockdown rescue in neural progenitors

    PMID:38272027

    Open questions at the time
    • How Seh1 recruits or stabilizes NuRD at target loci unknown
    • Single-lab study
  12. 2025 High

    Resolved inhibitory GATOR2 states showing the WDR24-Seh1L subcomplex as the direct Sestrin2 docking site and capturing the conformational dynamics underlying amino acid sensing.

    Evidence Cryo-EM structures of CASTOR1-, Sestrin2-, and dual-bound GATOR2 with HDX-MS

    PMID:40742811

    Open questions at the time
    • Direct link from sensor-induced conformation to RagA/B GAP modulation still incomplete
  13. 2026 Medium

    Mapped how the SEAC/GATOR engages the Rag-Ragulator complex, finding the GATOR1-equivalent does the direct binding while the Seh1-containing SEACAT contributes via a β-propeller required for robust signaling.

    Evidence Cryo-EM of yeast SEAC-EGOC complex with deletion mutants and TORC1 activity assays

    PMID:41680390

    Open questions at the time
    • Whether the SEACAT β-propeller recruits a GAP inhibitor not directly demonstrated
    • Yeast ortholog; human GATOR-Rag engagement geometry not confirmed

Open questions

Synthesis pass · forward-looking unresolved questions
  • How a single small β-propeller protein is partitioned between the NPC, GATOR2, and chromatin-silencing complexes, and what governs that partitioning, remains unresolved.
  • No mechanism described for how Seh1 is allocated among its distinct complexes
  • Mendelian disease association absent from the corpus despite microcephaly phenotypes in models

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 3 GO:0060090 molecular adaptor activity 2 GO:0098772 molecular function regulator activity 2
Localization
GO:0005694 chromosome 3 GO:0005634 nucleus 2 GO:0005635 nuclear envelope 2
Pathway
R-HSA-1640170 Cell Cycle 3 R-HSA-4839726 Chromatin organization 2 R-HSA-9609507 Protein localization 2
Partners
KAP1MIOSNUP85SEC13SESN2SETDB1WDR24WDR59
Complex memberships
GATOR2Nup107-160 (Nup84/Y-complex)SEA complex (yeast SEACAT)

Evidence

Reading pass · 22 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2013 SEH1L (Seh1L) is a subunit of the GATOR2 complex (together with Mios, WDR24, WDR59, and Sec13), which positively regulates mTORC1 signaling. Inhibition of GATOR2 subunits including Seh1L suppresses mTORC1 signaling; epistasis analysis shows GATOR2 negatively regulates DEPDC5 (a GATOR1 subunit), placing GATOR2 upstream of GATOR1 in the amino acid-sensing pathway to mTORC1. siRNA knockdown, epistasis analysis, co-immunoprecipitation, mTORC1 activity assays (phospho-S6K) Science High 23723238
2022 Cryo-EM structure of human GATOR2 reveals a 1.1 MDa, two-fold symmetric cage-like architecture. SEH1L and SEC13 are integrated into the octagonal scaffold through β-propeller blade donation (blade insertion), which stabilizes the GATOR2 complex and reveals an evolutionary relationship to the nuclear pore and membrane-coating complexes. The scaffold orients WD40 β-propeller dimers that mediate interactions with SESN2, CASTOR1, and GATOR1. Cryo-electron microscopy (cryo-EM) structure determination Nature High 35831510
2025 Cryo-EM structures of GATOR2 in inhibitory states (CASTOR1-bound, Sestrin2-bound, and dual-bound) show that Sestrin2 (leucine sensor) interacts specifically with the WDR24-Seh1L subcomplex of GATOR2, inducing conformational movements. HDX-MS confirmed dynamic motions in apo-GATOR2 and its complexes with amino acid sensors. Cryo-electron microscopy (cryo-EM), hydrogen-deuterium exchange mass spectrometry (HDX-MS) Cell reports High 40742811
2004 Seh1 is identified as a member of the Nup107-160 nuclear pore subcomplex in vertebrates. RNAi-mediated depletion of Seh1 leads to phenotypes similar to knockdown of other Nup107-160 constituents. Seh1, along with all other Nup107-160 complex members, is targeted to kinetochores from prophase to anaphase of mitosis. Co-immunoprecipitation, RNAi knockdown, GFP live-cell imaging, immunofluorescence Molecular biology of the cell High 15146057
2007 Depletion of Seh1 alone is sufficient to efficiently remove the Nup107-160 complex from kinetochores, causing mitotic delay, impaired chromosome congression, reduced kinetochore tension, and kinetochore-microtubule attachment defects. The presence of the Nup107-160 complex at kinetochores (dependent on Seh1) is required for the recruitment of Crm1 and RanGAP1-RanBP2 to kinetochores. siRNA knockdown, immunofluorescence, live-cell imaging, mitotic phenotype analysis The EMBO journal High 17363900
2009 Seh1 depletion impairs Aurora B localization to centromeres (the chromosomal passenger complex, CPC), resulting in defects in biorientation and organization of the spindle midzone and midbody. Seh1 regulates chromosome alignment and segregation by controlling centromeric localization of Aurora B; microtubule-kinetochore attachments (assessed by EM) are intact in Seh1-depleted cells. siRNA knockdown, immunofluorescence, electron microscopy, live-cell imaging Molecular biology of the cell High 19864462
2018 Using chemical genetics (auxin-inducible degron) and quantitative chromosome proteomics, Seh1 is shown to be dispensable for association of the Nup107 complex with mitotic chromosomes, but essential for the association of the GATOR2 complex and nucleoporin Nup153 with mitotic chromosomes. Seh1 is also required at human centromeres for efficient localization of the chromosomal passenger complex (CPC). Auxin-inducible degron (chemical genetics), quantitative mass spectrometry-based chromosome proteomics, immunofluorescence Journal of cell science High 29618633
2011 In Drosophila, Seh1 (SEH1L ortholog) associates with the product of the missing oocyte (mio) gene (a GATOR2 component). Loss of seh1 in the female germline causes failure of oocytes to maintain the meiotic cycle (pseudo-nurse cell development), phenocopying mio mutants. Mio protein accumulation is greatly diminished in seh1 mutant background, indicating Seh1 stabilizes Mio. Seh1 is dispensable for development of somatic tissues. Genetic null allele, co-immunoprecipitation, immunofluorescence, genetic interaction analysis Development High 21521741
2014 In Drosophila, GATOR2 components Mio and Seh1 are required to oppose Iml1/GATOR1 activity to prevent constitutive inhibition of TORC1, and their loss causes a block to oocyte growth and development. Epistasis analysis places GATOR2 (including Seh1) as an antagonist of GATOR1 in the TORC1 pathway during oogenesis. Genetic null alleles, epistasis analysis, rapamycin treatment, TORC1 activity assays Proceedings of the National Academy of Sciences High 25512509
2011 The SEA (Seh1-associated) complex in yeast contains Seh1 and Sec13 (along with Npr2, Npr3, and Sea1-Sea4). Combined computational and biochemical analysis indicates SEA complex proteins possess structural characteristics similar to membrane coating complexes (COPI, COPII, NPC). The SEA complex dynamically associates with the vacuole in vivo and functions in intracellular trafficking, amino acid biogenesis, and response to nitrogen starvation. Affinity purification/mass spectrometry, computational structural prediction, live-cell fluorescence microscopy, genetic assays Molecular & cellular proteomics High 21454883
2013 In yeast, SEACAT (the GATOR2 equivalent subcomplex containing Seh1, Sea2-4, and Sec13) antagonizes the GAP function of SEACIT (GATOR1 equivalent) toward Gtr1 (RagA ortholog), as demonstrated by genetic epistasis. Loss of SEACAT subunits suppresses TORC1 activity downstream of amino acid signaling. Genetic epistasis analysis, TORC1 activity assays Cell cycle Medium 23974112
2016 In Drosophila, Seh1 (GATOR2 component) has a TORC1-independent role in the regulation of lysosome function and autophagic flux, in addition to its role in TORC1 activation. This TORC1-independent lysosome function is shared with other GATOR2 members Mio and Wdr24. Genetic null alleles, epistasis analysis with GATOR1 components, lysosome acidification assays, autophagy flux assays PLoS genetics Medium 27166823
2009 The crystal structure of Nup85 in complex with Seh1 defines a new tripartite protein element (ancestral coatomer element ACE1) shared with other nucleoporins and vesicle coat proteins. Seh1 forms the short arm of the Y-shaped Nup84 complex together with Nup85. Functional sites predicted by analogy to COPII coat interactions were verified experimentally. Crystal structure determination, mutagenesis, functional interaction assays Communicative & integrative biology Medium 19641729
2023 Seh1 (SEH1L) maintains Schwann cell homeostasis by safeguarding genome stability through mediating the interaction between SETDB1 and KAP1. Loss of Seh1 disrupts this interaction, derepresses endogenous retroviruses, and triggers ZBP1-dependent necroptosis in Schwann cells, leading to progressive reduction of non-myelinating Schwann cells and neural fiber degeneration. Conditional knockout, co-immunoprecipitation, transcriptome analysis, immunofluorescence, necroptosis assays Cell reports Medium 37453065
2024 Seh1 cooperates with the NuRD transcription repressor complex at the nuclear periphery to repress p21 expression in neural stem cells. Depletion of Seh1 in radial glial progenitors derepresses p21, leading to defective neural progenitor proliferation and differentiation, impaired neurogenesis, and microcephaly. This function is independent of nucleocytoplasmic transport defects. Conditional knockout, transcriptome analysis, p21 knockdown rescue experiment, co-localization/nuclear periphery association assays Developmental cell Medium 38272027
2021 Seh1 and Nup43 are dispensable in pluripotent mouse embryonic stem cells but required for normal cell growth rates and viability upon neuroectodermal differentiation, as well as maintenance of proper nuclear pore complex density. An N-terminally truncated Nup85 mutation that greatly impairs interaction with Seh1 reduces NPC density but does not affect proliferation or differentiation, indicating Y-complex integrity (not NPC number per se) is critical. CRISPR/Cas9 genome editing, cell viability assays, NPC density quantification by electron microscopy/immunofluorescence, differentiation assays Journal of cell science Medium 34037234
2004 In S. pombe, Seh1 (ortholog) is localized at the nuclear envelope as part of the conserved Nup107-120 complex. Deletion of Nup107-120 complex members causes mRNA export defects and cell division defects (abnormal septa, mitotic spindles, chromosome missegregation) at restrictive temperature; genetic interaction with the Ran GTPase pathway is demonstrated by synthetic toxicity of a nonfunctional Ran-GFP allele in nup120 and nup133 deletion backgrounds. Deletion mutants, fluorescence microscopy, mRNA export assays, genetic epistasis/synthetic lethality Molecular and cellular biology Medium 15226438
2007 Seh1 (yeast) directly interacts with importin Kap95 as detected by the Bead Halo equilibrium binding assay, suggesting a role for this interaction during nuclear pore complex biogenesis. Bead Halo in vitro binding assay (equilibrium-based) Molecular & cellular proteomics Low 17897934
2018 SEH1 contains a RV[S/T]F motif (PP1-binding motif) that is phosphorylated specifically during mitosis, predominantly by Aurora B kinase, abrogating PP1 binding to SEH1. This represents a mechanism by which Aurora B and PP1 coordinate to control mitotic progression via dissolution of PP1 holoenzymes. Phospho-specific antibody (RVpSF), mass spectrometry, kinase assays, immunoprecipitation Science signaling Medium 29764992
2026 In yeast, cryo-EM structure of the SEAC (GATOR) bound to the EGOC (Ragulator-Rag GTPase complex) shows a single SEAC interacts with two EGOC molecules via SEACIT, binding exclusively to the 'active' EGOC conformation, without involvement of SEACAT (which contains Seh1/Sea2-4/Sec13). The Sea2 β-propeller domain of SEACAT is required for robust amino acid signaling to TORC1, suggesting it recruits a GAP inhibitor for fast signaling. Cryo-electron microscopy, genetic analysis (deletion mutants), TORC1 activity assays Nature structural & molecular biology Medium 41680390
2024 SEH1L silencing activates the ATF3/HMOX1/GPX4 axis, decreases mitochondrial membrane potential and GSH while increasing ROS and MDA, inducing ferroptosis and suppressing hepatocellular carcinoma progression. Knockdown of ATF3 reverses these effects. These findings were validated in vitro and in vivo (subcutaneous tumor model). siRNA knockdown, next-generation sequencing, RT-qPCR, western blotting, flow cytometry, xenograft model Apoptosis Low 39095556
2023 Nup133 and Seh1, two components of the Y-complex NPC subassembly, independently regulate a subset of genes including Lhx1 and Nup210l during neuroectodermal differentiation. Gene regulation by Seh1 in neural progenitors appears independent of nuclear pore basket integrity (Seh1 depletion causes only mild reduction in NPC density). Transcriptomic analysis, siRNA/genetic depletion, NPC density quantification, differentiation assays Journal of cell science Low 37305998

Source papers

Stage 0 corpus · 49 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2013 A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science (New York, N.Y.) 888 23723238
2004 The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis. Molecular biology of the cell 224 15146057
2007 The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions. The EMBO journal 172 17363900
2010 NENA, a Lotus japonicus homolog of Sec13, is required for rhizodermal infection by arbuscular mycorrhiza fungi and rhizobia but dispensable for cortical endosymbiotic development. The Plant cell 152 20675572
2016 Involvement of GATOR complex genes in familial focal epilepsies and focal cortical dysplasia. Epilepsia 140 27173016
2011 A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae. Molecular & cellular proteomics : MCP 119 21454883
2013 SEACing the GAP that nEGOCiates TORC1 activation: evolutionary conservation of Rag GTPase regulation. Cell cycle (Georgetown, Tex.) 92 23974112
2022 Structure of the nutrient-sensing hub GATOR2. Nature 71 35831510
2004 The fission yeast Nup107-120 complex functionally interacts with the small GTPase Ran/Spi1 and is required for mRNA export, nuclear pore distribution, and proper cell division. Molecular and cellular biology 70 15226438
2015 A mutation in the nucleoporin-107 gene causes XX gonadal dysgenesis. The Journal of clinical investigation 69 26485283
2009 The Nup107-160 nucleoporin complex promotes mitotic events via control of the localization state of the chromosome passenger complex. Molecular biology of the cell 69 19864462
2007 Discovering novel interactions at the nuclear pore complex using bead halo: a rapid method for detecting molecular interactions of high and low affinity at equilibrium. Molecular & cellular proteomics : MCP 69 17897934
2018 Aurora B opposes PP1 function in mitosis by phosphorylating the conserved PP1-binding RVxF motif in PP1 regulatory proteins. Science signaling 68 29764992
2010 Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses. PLoS pathogens 60 20824097
2014 TORC1 regulators Iml1/GATOR1 and GATOR2 control meiotic entry and oocyte development in Drosophila. Proceedings of the National Academy of Sciences of the United States of America 54 25512509
2009 The structure of the scaffold nucleoporin Nup120 reveals a new and unexpected domain architecture. Structure (London, England : 1993) 51 19576787
2016 The GATOR2 Component Wdr24 Regulates TORC1 Activity and Lysosome Function. PLoS genetics 45 27166823
2011 The nucleoporin Seh1 forms a complex with Mio and serves an essential tissue-specific function in Drosophila oogenesis. Development (Cambridge, England) 40 21521741
2003 Characterization of mutations that are synthetic lethal with pol3-13, a mutated allele of DNA polymerase delta in Saccharomyces cerevisiae. Current genetics 40 12759774
2015 Unexpected ancient paralogs and an evolutionary model for the COPII coat complex. Genome biology and evolution 33 25747251
2020 Nuclear pore complex components have temperature-influenced roles in plant growth and immunity. Plant, cell & environment 25 32022936
2013 Puromycin resistance gene as an effective selection marker for ciliate Tetrahymena. Gene 25 24185080
2007 A syndromic form of autosomal recessive congenital microcephaly (Jawad syndrome) maps to chromosome 18p11.22-q11.2. Human genetics 20 18071751
2024 SEH1L siliencing induces ferroptosis and suppresses hepatocellular carcinoma progression via ATF3/HMOX1/GPX4 axis. Apoptosis : an international journal on programmed cell death 18 39095556
2018 Seh1 targets GATOR2 and Nup153 to mitotic chromosomes. Journal of cell science 16 29618633
2009 A lattice model of the nuclear pore complex. Communicative & integrative biology 15 19641729
2018 The TORC1 signaling pathway regulates respiration-induced mitophagy in yeast. Biochemical and biophysical research communications 14 29787763
2023 Nucleoporin Seh1 maintains Schwann cell homeostasis by regulating genome stability and necroptosis. Cell reports 13 37453065
2014 Analysis of the Lotus japonicus nuclear pore NUP107-160 subcomplex reveals pronounced structural plasticity and functional redundancy. Frontiers in plant science 13 24478780
2023 Functional differentiation of Sec13 paralogues in the euglenozoan protists. Open biology 12 37311539
2023 SP1-Induced Upregulation of LncRNA AFAP1-AS1 Promotes Tumor Progression in Triple-Negative Breast Cancer by Regulating mTOR Pathway. International journal of molecular sciences 11 37686205
2021 Disturbed intramitochondrial phosphatidic acid transport impairs cellular stress signaling. The Journal of biological chemistry 11 33497623
2025 Cryo-EM structures of amino acid sensors bound to the human GATOR2 complex. Cell reports 9 40742811
2024 New insights into GATOR2-dependent interactions and its conformational changes in amino acid sensing. Bioscience reports 7 38372438
2023 Y-complex nucleoporins independently contribute to nuclear pore assembly and gene regulation in neuronal progenitors. Journal of cell science 7 37305998
2021 Integrity of the short arm of the nuclear pore Y-complex is required for mouse embryonic stem cell growth and differentiation. Journal of cell science 6 34037234
2025 Genetic and clinical spectrum of steroid-resistant nephrotic syndrome with nuclear pore gene mutation. Pediatric nephrology (Berlin, Germany) 4 39814977
2025 Novel Cross-Cancer Hub Genes in Doxorubicin Resistance Identified by Transcriptional Mapping. Biomedicines 4 41153808
2024 Nucleoporin Seh1 controls murine neocortical development via transcriptional repression of p21 in neural stem cells. Developmental cell 4 38272027
2019 Nuclear Pore Complexes Are Key Regulators of Oligodendrocyte Differentiation and Function. Neuron 4 31071281
2025 mTOR signaling controls protein aggregation during heat stress and cellular aging in a translation- and Hsf1-independent manner. The Journal of biological chemistry 2 39798875
2025 Screening, identification, and experimental validation of SUMOylation biomarkers in Parkinson's disease. Hereditas 2 40781725
2025 The Whi2-Psr1-Psr2 complex selectively regulates TORC1 and autophagy under low leucine conditions but not nitrogen depletion. Autophagy 1 40103213
2023 A novel view to varicose veins pathogenesis: Proteomic profiling suggests a pivotal role of extracellular matrix degradation. Phlebology 1 37846077
2026 Structure and function of the yeast amino acid-sensing SEAC-EGOC supercomplex. Nature structural & molecular biology 0 41680390
2026 Glycolytic-Cholesterol Subtypes of Severe Asthma Reveal Distinct Immune-Inflammatory and Metabolic Phenotypes. Journal of inflammation research 0 41940036
2025 Exploration and verification of circulating diagnostic biomarkers in osteoarthritis based on machine learning. Frontiers in genetics 0 40034747
2025 Reversing the Irreversible: miRNA-Targeting Mesyl Phosphoramidate Oligonucleotides Restore Sensitivity to Cisplatin and Doxorubicin of KB-8-5 Epidermoid Carcinoma Cells. Biomedicines 0 41463125
2022 Vps501 links sorting nexins to TORC1 regulation in budding yeast. Autophagy reports 0 40396006

Missed literature

Know a paper Affinage missed for SEH1L? Flag it for the maintainers and the community.

No submissions yet.