Affinage

NOP2

28S rRNA (cytosine(4447)-C(5))-methyltransferase · UniProt P46087

Length
812 aa
Mass
89.3 kDa
Annotated
2026-06-10
41 papers in source corpus 21 papers cited in narrative 21 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/7 claims corpus-supported (86%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

NOP2 (NSUN1/p120) is an essential nucleolar S-adenosylmethionine-dependent RNA methyltransferase that couples ribosome biogenesis to RNA m5C modification and serves as a trans-acting factor in large ribosomal subunit production (PMID:7806561, PMID:11452018, PMID:36161484). In yeast, Nop2p is an essential nucleolar protein whose loss blocks processing of 27S pre-rRNA to mature 25S rRNA and depletes 60S subunits specifically, defining its role in large-subunit biogenesis (PMID:7806561, PMID:11452018). The human enzyme deposits m5C at position 4447 of 28S rRNA, but its function in pre-rRNA processing is largely non-catalytic: NOP2/NSUN1 binds the 5'ETS of pre-rRNA and forms complexes with box C/D snoRNAs U3 and U8, facilitating their recruitment to pre-90S particles and stable snoRNP assembly, with catalytically inactive enzyme fully rescuing processing defects (PMID:36161484). This ribosome-biogenesis function is the primary physiological lesion in vivo: NOP2 is required for nucleolar maturation, lineage specification, and embryonic development across mouse and bovine embryos, and its zebrafish knockout causes microcephaly and cerebral edema with impaired pre-ribosomal processing driving p53-dependent apoptosis upstream of the neurogenic phenotype (PMID:26632338, PMID:31908012, PMID:41631357). Beyond rRNA, NOP2 acts as an m5C 'writer' on numerous mRNAs—including c-Myc, EZH2, APOL1, TPI1, LMNB2, SCD, and NFKB1—where methylation modulates transcript stability through m5C readers ALYREF and YBX1, reprogramming metabolism, EMT, and proliferation in multiple cancers (PMID:36161484, PMID:37398932, PMID:39013911, PMID:39309431). NOP2 also has nuclear regulatory roles: it binds the cyclin D1 promoter and, together with TERC-associated telomerase, activates its transcription (PMID:26906424), and it represses HIV-1 transcription by associating with the 5' LTR and competing with Tat for TAR RNA binding through its methyltransferase domain (PMID:32176734). NOP2 isoform 3 interacts with TDP-43 independently of RNA and drives m5C-RNA hypermethylation linked to TDP-43 neurodegeneration (PMID:41188020), and its own mRNA is stabilized by NAT10-mediated ac4C modification (PMID:37768430).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 1994 High

    Established NOP2 as an essential nucleolar protein, anchoring its biology to the nucleolus before any molecular activity was known.

    Evidence Immunofluorescence, subcellular fractionation, EM, and overexpression of yeast Nop2p

    PMID:7806561

    Open questions at the time
    • No catalytic activity or substrate defined
    • Mechanism of nucleolar morphology change unexplained
  2. 2001 High

    Defined the first concrete mechanistic role—a trans-acting factor needed for 27S-to-25S pre-rRNA processing and 60S subunit production—distinguishing large- from small-subunit biogenesis.

    Evidence Temperature-sensitive nop2 alleles with ribosome subunit and pre-rRNA processing analysis in S. cerevisiae

    PMID:11452018

    Open questions at the time
    • Whether processing requires catalytic methylation unresolved
    • No direct RNA or protein partners identified
  3. 2016 Medium

    Extended NOP2 beyond the nucleolus to transcriptional control, showing it activates the cyclin D1 promoter in concert with TERC-associated telomerase.

    Evidence Co-IP, ChIP, promoter reporter assays, siRNA in human cells

    PMID:26906424

    Open questions at the time
    • Mechanism of promoter binding specificity unclear
    • Single lab
  4. 2015 Medium

    Demonstrated NOP2 is required for mammalian preimplantation development with global RNA reduction, linking the molecular role to organismal phenotype.

    Evidence RNAi knockdown in mouse embryos with RNA quantification and lineage analysis

    PMID:26632338

    Open questions at the time
    • Cannot separate rRNA from mRNA contribution
    • Catalytic requirement not tested
  5. 2020 High

    Revealed a host-defense function: NOP2 suppresses HIV-1 transcription by occupying the LTR and competing with Tat for TAR RNA via its methyltransferase domain.

    Evidence ChIP, RIP, RNA methylation, domain mutagenesis, and latency reactivation assays

    PMID:32176734

    Open questions at the time
    • Relative contribution of TAR m5C versus Tat competition not quantified
    • Single lab
  6. 2022 High

    Identified the human rRNA substrate (m5C4447 on 28S) and, critically, separated catalytic from non-catalytic functions—showing snoRNP-mediated pre-rRNA processing is methylation-independent.

    Evidence miCLIP-seq, complementation with WT and catalytic mutant, snoRNP assembly assays

    PMID:36161484

    Open questions at the time
    • Functional consequence of m5C4447 itself undefined
    • Structural basis of U3/U8 recruitment unknown
  7. 2023 Medium

    Opened the mRNA m5C-writer paradigm, showing NOP2 methylates c-Myc mRNA in an EIF3A-dependent manner to control its degradation and metabolic reprogramming.

    Evidence m5C/RIP/RNA stability assays and EIF3A epistasis in HCC cells

    PMID:37398932

    Open questions at the time
    • Mechanism coupling m5C to EIF3A-dependent decay unclear
    • Single lab
  8. 2024 Medium

    Generalized NOP2 mRNA methylation to reader-dependent stabilization, identifying ALYREF and YBX1 as readers for EZH2 and APOL1 transcripts driving EMT and PI3K-Akt signaling.

    Evidence MeRIP/bisulfite sequencing, RIP, RNA stability, ChIP in lung and renal cancer cells

    PMID:39013911 PMID:39309431

    Open questions at the time
    • Target selectivity determinants unknown
    • Each axis from a single lab
  9. 2025 Medium

    Linked NOP2 to neurodegeneration, showing isoform-3 interacts with TDP-43 RNA-independently and drives pathogenic m5C hypermethylation.

    Evidence Co-IP/MS interactome, Drosophila genetic epistasis, postmortem human brain analysis

    PMID:41188020

    Open questions at the time
    • Human disease causation not established
    • Isoform-specific interaction surface undefined
  10. 2026 Medium

    Established ribosome biogenesis as the primary in vivo lesion, with p53-dependent apoptosis as a downstream consequence of NOP2 loss in a vertebrate.

    Evidence CRISPR/Cas9 zebrafish knockout, Ribo-seq, tp53 genetic epistasis

    PMID:41631357

    Open questions at the time
    • Microcephaly persists despite p53 rescue—additional pathway implicated
    • Catalytic versus non-catalytic contribution not dissected
  11. 2026 Low

    Broadened the mRNA m5C-stabilization mechanism across diverse disease contexts (TPI1, LMNB2, SCD, NFKB1) implicating glycolysis, ferroptosis resistance, and inflammation.

    Evidence MeRIP, RIP, RNA stability and rescue assays across multiple cancer and disease models

    PMID:40366008 PMID:41498196 PMID:41766206 PMID:42088435

    Open questions at the time
    • Each axis is single-lab without independent replication
    • Direct methylation site mapping limited in several studies
  12. 2026 Medium

    Connected NOP2 rRNA methylation to oncogenic metabolic demand, showing MYC and methionine availability tune NOP2 and selectively support MYC-driven tumor growth.

    Evidence Heavy-isotope methionine tracing, rRNA methylation analysis, MYC vs RAS epistasis (preprint)

    PMID:41659612

    Open questions at the time
    • Preprint, not peer-reviewed
    • Causal link between specific 28S sites and proliferation not established

Open questions

Synthesis pass · forward-looking unresolved questions
  • How NOP2 selects its diverse mRNA substrates and how its catalytic m5C activity is functionally apportioned between rRNA, mRNA, and viral RNA targets remains unresolved.
  • No structural model of substrate recognition
  • No unifying determinant of mRNA target selection
  • Catalytic vs non-catalytic contributions undissected across most contexts

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140098 catalytic activity, acting on RNA 5 GO:0003723 RNA binding 3 GO:0016740 transferase activity 2 GO:0140110 transcription regulator activity 1
Localization
GO:0005730 nucleolus 3 GO:0005654 nucleoplasm 1
Pathway
R-HSA-1852241 Organelle biogenesis and maintenance 3 R-HSA-74160 Gene expression (Transcription) 2 R-HSA-8953854 Metabolism of RNA 2
Partners
ALYREFEIF3ANAT10PVT1TDP-43TERCYBX1
Complex memberships
box C/D snoRNP (U3/U8)pre-90S ribosomal particle

Evidence

Reading pass · 21 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1994 Yeast Nop2p (ortholog of human NOP2/p120) is an essential nucleolar protein required for cell viability; it localizes primarily to the nucleolus as determined by indirect immunofluorescence and nuclear fractionation, and its overexpression alters nucleolar morphology (detachment from nuclear envelope, fragmentation) without affecting ribosome subunit synthesis levels. Indirect immunofluorescence, subcellular fractionation, electron microscopy, GAL10-driven overexpression, SDS-PAGE The Journal of cell biology High 7806561
2001 Temperature-sensitive nop2 alleles in S. cerevisiae cause defective processing of 27S pre-rRNA to mature 25S rRNA and dramatic reductions in 60S ribosome subunits under non-permissive conditions, without significantly affecting 40S subunits or 18S rRNA, establishing Nop2p as a trans-acting factor required for large ribosomal subunit biogenesis and rRNA processing. Molecular genetics (temperature-sensitive alleles), ribosome subunit analysis, pre-rRNA processing assays Nucleic acids research High 11452018
2014 LncRNA-hPVT1 binds to NOP2 protein (identified by RNA pulldown and mass spectrometry) and enhances stability of NOP2 protein, with NOP2 being required for PVT1-mediated promotion of HCC cell proliferation, cell cycling, and stem cell-like properties. RNA pulldown, mass spectrometry, gain-of-function and loss-of-function experiments Hepatology (Baltimore, Md.) Medium 25043274
2015 RNAi-mediated knockdown of Nop2 in mouse preimplantation embryos causes developmental arrest at morula stage with reduced blastomere numbers, increased apoptosis, impaired cell-lineage specification, and global reduction of all RNA species including rRNA, snRNA, snoRNA, and mRNA, demonstrating that NOP2 is required for RNA processing and/or stability during preimplantation development. RNAi knockdown in mouse embryos, RNA quantification, apoptosis assays, lineage marker analysis Molecular reproduction and development Medium 26632338
2016 NOL1 (NOP2) was identified as a TERC-binding protein associated with catalytically active telomerase; NOL1 binds to the TCF-binding element of the cyclin D1 promoter and activates its transcription; telomerase is recruited to the cyclin D1 promoter in a TERC-dependent manner through interaction with NOL1, further enhancing cyclin D1 transcription; depletion of NOL1 suppresses cyclin D1 promoter activity and induces growth arrest and altered cell cycle distributions. Co-immunoprecipitation, chromatin immunoprecipitation (ChIP), promoter reporter assays, siRNA knockdown Journal of cell science Medium 26906424
2019 NOP2 depletion in mouse preimplantation embryos disrupts nucleolar maturation (increased nucleolus precursor body ratio, decreased nucleolus size ratio by TEM) and reduces rRNA abundance (by qPCR and FISH), impairs first lineage specification (reduced TEAD4, NANOG, KLF4), with conserved function confirmed in bovine embryos. RNAi knockdown, transmission electron microscopy, RNA-seq, FISH, qPCR, immunofluorescence FASEB journal Medium 31908012
2020 NOP2 suppresses HIV-1 transcription and promotes viral latency by: (1) associating with HIV-1 5' LTR chromatin, (2) competing with HIV-1 Tat protein for binding to TAR RNA, and (3) contributing to m5C methylation of TAR RNA; the RNA methyltransferase catalytic domain (MTD) of NOP2 mediates its competition with Tat and binding with TAR. Loss- and gain-of-function analyses, chromatin immunoprecipitation, RNA immunoprecipitation, RNA methylation assays, domain mutagenesis, HIV-1 latency reactivation assays PLoS pathogens High 32176734
2022 Human NOP2/NSUN1 catalyzes deposition of m5C at position 4447 on 28S rRNA (identified by miCLIP-seq); NOP2/NSUN1 also binds the 5'ETS region of pre-rRNA and regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs (U3 and U8), facilitating their recruitment to pre-90S ribosomal particles and stable assembly into snoRNP complexes; both WT and catalytically inactive NOP2/NSUN1 rescue rRNA processing defects and snoRNP assembly in knockdown background, demonstrating m5C catalytic activity is dispensable for ribosome biogenesis. miCLIP-seq, siRNA knockdown, complementation with WT and catalytic mutant, snoRNP assembly assays, pre-rRNA processing analysis Nucleic acids research High 36161484
2023 NOP2 catalyzes m5C modification of c-Myc mRNA in an EIF3A-dependent manner; m5C methylation of c-Myc mRNA induces its degradation dependent on EIF3A, thereby reducing c-Myc expression and reprogramming glucose metabolism; MAZ transcription factor directly controls NOP2 expression in HCC. m5C methylation assays, RNA immunoprecipitation, RNA stability assays, EIF3A co-functional experiments, ChIP for MAZ binding, loss-of-function assays Research (Washington, D.C.) Medium 37398932
2023 NOP2 methylates XPD mRNA at m5C sites, enhancing XPD mRNA stability; NOP2 overexpression elevated XPD expression and inhibited HCC cell proliferation, migration, and invasion in vitro. m5C methylation assays, RNA stability assays, in vitro functional assays Neoplasma Low 37498063
2023 NAT10-mediated ac4C modification of Nop2 mRNA stabilizes it and enhances translation; NAT10 knockdown decreases ac4C on Nop2 mRNA and reduces NOP2 RNA and protein abundance; NOP2 depletion inhibits translation of transcription factor TEAD4, leading to defective Cdx2 expression and failure of trophectoderm fate specification; exogenous Nop2 mRNA partially rescues abnormal development. acRIP-PCR, single-cell sequencing, RNA-seq, embryonic phenotype monitoring, mRNA rescue experiments Cellular and molecular life sciences Medium 37768430
2024 NOP2 deposits m5C on EZH2 mRNA, stabilizing it in an ALYREF (m5C reader)-dependent manner; NOP2/ALYREF/EZH2 axis promotes EMT in lung cancer cells; EZH2 counteracts NOP2 effects on H3K27me3 occupancy at the E-cadherin promoter, repressing E-cadherin expression. RNA-seq, methylated RNA immunoprecipitation (MeRIP), RNA stability assays, ChIP, in vitro and in vivo functional assays Cell death & disease Medium 39013911
2024 NOP2 stimulates m5C modification of APOL1 mRNA; m5C reader YBX1 recognizes and binds the m5C site in the 3'-UTR of APOL1 mRNA, stabilizing it; NOP2/APOL1 axis activates PI3K-Akt signaling to promote ccRCC progression. m5C bisulfite sequencing, RNA-seq, RIP/MeRIP RT-qPCR, luciferase reporter assay, RNA stability assay, loss/gain-of-function assays International journal of biological sciences Medium 39309431
2025 NSUN1 (NOP2) isoform 3 selectively interacts with TDP-43 independently of RNA in human cells; aberrant Nsun1 activity drives TDP-43-induced m5C-RNA hypermethylation in a Drosophila model; Nsun1 downregulation alleviates TDP-43-induced neurodegeneration, lifespan deficits, and cytoplasmic accumulation of TDP-43; NSUN1 is nucleolar and interacts with TDP-43 in both nucleolar and nucleoplasmic compartments. TDP-43 interactome mapping (co-IP/MS), Drosophila genetic epistasis, m5C-RNA quantification, isoform-specific interaction assays, postmortem human brain analysis Life science alliance Medium 41188020
2025 NOP2 catalyzes m5C modification of COL1A1 mRNA, stabilizing it; tranilast treatment reduces NOP2 expression and directly interacts with NOP2 (by RIP), decreasing m5C on COL1A1 mRNA, reducing COL1A1 expression, and suppressing hypertrophic scar fibroblast proliferation, migration, and invasion. MeRIP, RIP, dual luciferase reporter assay, dot blot, cell functional assays Tissue & cell Low 41260007
2026 NOP2 knockout in zebrafish (CRISPR/Cas9) causes embryonic lethality within 3-5 dpf with microcephaly and cerebral edema; nop2 deficiency impairs differentiation of neural progenitors, activates p53-dependent apoptosis in neural cells, and compromises pre-ribosomal particle processing; genetic epistasis shows tp53 mutation partially rescues neurogenic defects and cerebral edema but not microcephaly, establishing ribosome biogenesis defects as the primary molecular lesion upstream of p53 apoptosis. CRISPR/Cas9 knockout, Ribo-seq, ribosome processing assays, p53 epistasis experiments, histology/immunostaining FASEB journal Medium 41631357
2026 NOP2 promotes glycolysis in larynx cancer by depositing m5C on TPI1 mRNA, stabilizing it; NOP2 silencing reduces m5C modification on TPI1 mRNA and decreases TPI1 mRNA stability; overexpression of TPI1 rescues impaired glycolysis caused by NOP2 knockdown. MeRIP, RIP, dual-luciferase reporter assay, RNA stability assay, functional metabolic assays, xenograft models Molecular carcinogenesis Low 41498196
2026 NOP2 deposits m5C on LMNB2 mRNA, enhancing its stability and elevating LMNB2 protein levels; LMNB2 overexpression rescues the suppressed malignant phenotypes induced by NOP2 knockdown in colorectal cancer cells, establishing LMNB2 as a critical downstream effector of NOP2. MeRIP-seq, RIP-seq, transcriptomic sequencing, RNA stability assays, rescue overexpression experiments, in vitro and in vivo functional assays Cancer medicine Low 40366008
2026 NOP2-mediated m5C deposition on SCD mRNA facilitates recruitment of m5C reader YBX1, stabilizing SCD mRNA and boosting SCD expression; the NOP2/YBX1/SCD axis orchestrates lipid metabolism reprogramming (altering saturated, monounsaturated, and polyunsaturated fatty acid distribution) to suppress lipid peroxidation and protect bladder cancer cells from ferroptosis. MeRIP, RIP, RNA stability assays, lipid profiling, in vitro and xenograft functional assays International journal of biological sciences Low 42088435
2026 NOP2 stabilizes NFKB1 mRNA through m5C modification; NOP2 knockdown inhibits NFKB1 transcription by decreasing m5C modification on NFKB1 mRNA; NFKB1 overexpression restores inflammation and apoptosis inhibited by NOP2 knockdown in LPS-induced bronchial epithelial cells, establishing a NOP2/m5C/NFKB1 axis in COPD. MeRIP, RNA stability assays, rescue overexpression, in vivo rat COPD model, cytokine measurement Journal of biochemical and molecular toxicology Low 41766206
2026 In MYC-driven liver cancer cells, NOP2 (rRNA m5C-methyltransferase) expression is regulated by both MYC overexpression and methionine abundance; NOP2 knockdown reduces methylation of multiple 28S rRNA residues and selectively inhibits MYC-driven (but not RAS-driven) liver cancer cell proliferation and in vivo tumor growth. Heavy isotope methionine tracing, NOP2 knockdown, rRNA methylation analysis, in vivo tumor growth assays, methionine depletion experiments bioRxivpreprint Medium 41659612

Source papers

Stage 0 corpus · 41 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2014 Oncofetal long noncoding RNA PVT1 promotes proliferation and stem cell-like property of hepatocellular carcinoma cells by stabilizing NOP2. Hepatology (Baltimore, Md.) 385 25043274
2023 NOP2-mediated m5C Modification of c-Myc in an EIF3A-Dependent Manner to Reprogram Glucose Metabolism and Promote Hepatocellular Carcinoma Progression. Research (Washington, D.C.) 95 37398932
2022 Human NOP2/NSUN1 regulates ribosome biogenesis through non-catalytic complex formation with box C/D snoRNPs. Nucleic acids research 82 36161484
2013 Expression of NOL1/NOP2/sun domain (Nsun) RNA methyltransferase family genes in early mouse embryogenesis. Gene expression patterns : GEP 80 23816522
2019 NOP2/Sun RNA methyltransferase 2 promotes tumor progression via its interacting partner RPL6 in gallbladder carcinoma. Cancer science 79 31487418
2020 Nucleolar protein NOP2/NSUN1 suppresses HIV-1 transcription and promotes viral latency by competing with Tat for TAR binding and methylation. PLoS pathogens 70 32176734
1994 Yeast NOP2 encodes an essential nucleolar protein with homology to a human proliferation marker. The Journal of cell biology 68 7806561
2020 The ribosomal RNA m5C methyltransferase NSUN-1 modulates healthspan and oogenesis in Caenorhabditis elegans. eLife 41 33289480
2020 Long noncoding RNA LINC00963 induces NOP2 expression by sponging tumor suppressor miR-542-3p to promote metastasis in prostate cancer. Aging 38 32554858
2016 Telomerase activates transcription of cyclin D1 gene through an interaction with NOL1. Journal of cell science 36 26906424
2008 E2A-ZNF384 and NOL1-E2A fusion created by a cryptic t(12;19)(p13.3; p13.3) in acute leukemia. Leukemia 33 18185522
2024 NOP2 facilitates EZH2-mediated epithelial-mesenchymal transition by enhancing EZH2 mRNA stability via m5C methylation in lung cancer progression. Cell death & disease 32 39013911
2014 Nop2 is expressed during proliferation of neural stem cells and in adult mouse and human brain. Brain research 32 25481415
2001 Temperature sensitive nop2 alleles defective in synthesis of 25S rRNA and large ribosomal subunits in Saccharomyces cerevisiae. Nucleic acids research 28 11452018
2020 Long Noncoding RNA PVT1 Promotes Prostate Cancer Metastasis by Increasing NOP2 Expression via Targeting Tumor Suppressor MicroRNAs. OncoTargets and therapy 27 32764963
2015 Nop2 is required for mammalian preimplantation development. Molecular reproduction and development 27 26632338
2023 NOP2-mediated m5C methylation of XPD is associated with hepatocellular carcinoma progression. Neoplasma 23 37498063
2023 Function of m5C RNA methyltransferase NOP2 in high-grade serous ovarian cancer. Cancer biology & therapy 22 37800580
2019 The nucleolar protein NOP2 is required for nucleolar maturation and ribosome biogenesis during preimplantation development in mammals. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 21 31908012
2019 Effect of NOP2 knockdown on colon cancer cell proliferation, migration, and invasion. Translational cancer research 18 35116980
2024 NOP2-mediated 5-methylcytosine modification of APOL1 messenger RNA activates PI3K-Akt and facilitates clear cell renal cell carcinoma progression. International journal of biological sciences 16 39309431
2024 Bipyridine Derivatives as NOP2/Sun RNA Methyltransferase 3 Inhibitors for the Treatment of Colorectal Cancer. Journal of medicinal chemistry 14 39054645
1991 Establishment and characterization of a new human Bence Jones-type myeloma cell line, NOP-2. International journal of hematology 14 1747447
2022 Molecular Characterization Clinical and Immunotherapeutic Characteristics of m5C Regulator NOP2 Across 33 Cancer Types. Frontiers in cell and developmental biology 10 35372330
2023 N4-acetylcytidine of Nop2 mRNA is required for the transition of morula-to-blastocyst. Cellular and molecular life sciences : CMLS 9 37768430
2025 NOP2-Mediated m5C Methylation Modification of LMNB2 mRNA Facilitates Colorectal Cancer Progression. Cancer medicine 6 40366008
2025 Nop2/Sun domain family member 5 contributes to tumorigenic properties in prostate cancer by engaging the PI3K-AKT pathway and tumor-associated macrophages. Biochimica et biophysica acta. Molecular basis of disease 4 40633812
2024 Mice with NOP2/sun RNA methyltransferase 5 deficiency die before reaching puberty due to fatal kidney damage. Renal failure 3 38712768
2008 Nucleolar protein 1 (Nol1) expression in the mouse brain. Collegium antropologicum 3 18405070
2024 NOP2/Sun RNA Methyltransferase 4 Regulates the Mammalian Target of Rapamycin Signaling Pathway to Promote Hepatocellular Carcinoma Progression. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 2 39634439
2025 Polymorphisms in the NSUN1 gene and neuroblastoma risk in Chinese children from Jiangsu province. Journal of Cancer 1 39744478
2025 Reactive Oxygen Species-Responsive Ferrocene Nanoparticles Delivering Small Interfering RNA Targeting NOP2/Sun RNA Methyltransferase Family Member 2 for Gastric Cancer Therapy. Biomaterials research 1 40444266
2026 NOP2 Promotes Glycolysis and Tumor Development in Larynx Cancer by Stabilizing TPI1 mRNA Through N5-Methylcytosine Modification. Molecular carcinogenesis 0 41498196
2026 Nucleolar Protein Nop2 Promotes Neural Differentiation by Regulating Ribosome Biogenesis-Related Processes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 0 41631357
2026 Methionine metabolism and the NOP2 methyltransferase are essential for MYC-Driven liver tumorigenesis. bioRxiv : the preprint server for biology 0 41659612
2026 Knockdown of 5-methylcytosine RNA methyltransferase NOP2/sun RNA methyltransferase 5 in hepatocellular carcinoma cells affects their biological functions. World journal of gastrointestinal surgery 0 41695847
2026 NOP2 Promotes Inflammation and Apoptosis in Chronic Obstructive Pulmonary Disease by Enhancing m5C Modification of NFKB1. Journal of biochemical and molecular toxicology 0 41766206
2026 NOP2-mediated 5-methylcytosine Regulates Lipid Metabolism Reprogramming to Prime Tumors for Ferroptosis in Bladder Cancer Progression. International journal of biological sciences 0 42088435
2025 Aberrant NSUN1 activity connects m5C-RNA modification to TDP-43 neurotoxicity in ALS/FTD. Life science alliance 0 41188020
2025 Tranilast inhibits cell proliferation, migration and invasion of human hypertrophic scar fibroblasts by NOP2-mediated m5C methylation on COL1A1. Tissue & cell 0 41260007
2023 Long Noncoding RNA PVT1 Promotes Prostate Cancer Metastasis by Increasing NOP2 Expression via Targeting Tumor Suppressor MicroRNAs [Retraction]. OncoTargets and therapy 0 37719641

Missed literature

Know a paper Affinage missed for NOP2? Flag it for the maintainers and the community.

No submissions yet.