Affinage

NMT1

Glycylpeptide N-tetradecanoyltransferase 1 · UniProt P30419

Length
496 aa
Mass
56.8 kDa
Annotated
2026-06-10
42 papers in source corpus 11 papers cited in narrative 13 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

NMT1 is an essential N-myristoyltransferase that transfers myristate from myristoyl-CoA onto the N-terminal glycine α-amino group of substrate proteins, a co- and post-translational lipid modification that governs substrate stability, trafficking, and downstream signaling (PMID:1429724, PMID:36617552). The enzyme is monomeric, with a minimal catalytic domain whose substrate- and acyl-CoA-binding sites require functional contributions from both its amino- and carboxyl-terminal halves (PMID:1429724); structural and kinetic work shows it preferentially catalyzes glycine myristoylation through a water-mediated chemistry while also performing less efficient lysine ε-amino myristoylation via direct interaction with the catalytic base (PMID:36181773). Through these modifications NMT1 controls the fate of diverse substrates: it directs membrane and trafficking outcomes, sending myristoylated TMEM106B to lysosomes for degradation while non-myristoylated TMEM106B accumulates at the cell surface (PMID:40451428), and promoting CHP1-dependent translocation of PD-L1 to the plasma membrane to enable immune evasion under hypoxia (PMID:40605065). NMT1 also acts as a stability switch by modulating ubiquitin-mediated degradation—stabilizing ICAM-1 by inhibiting the E3 ligase FBXO4 (PMID:37269961) and differentially destabilizing or stabilizing distinct protein classes in liver cancer through E3-ligase-dependent ubiquitination (PMID:34136404). Beyond protein targets, NMT1 shapes signaling through its product and substrate networks, regulating ROS/JNK-driven autophagy (PMID:30446635), NFκB/Bcl-2 signaling via VILIP3 (PMID:36617552), and an NMT1/myristic-acid/VPS15 axis in cerebral ischemia (PMID:40221008). Its catalytic activity is druggable at Asn-246 by small molecules including desloratadine and by pan-NMT inhibitors such as PCLX-001 and DDD85464, the latter blocking myristoylation of viral Z and stable-signal-peptide proteins required for mammarenavirus multiplication (PMID:36617552, PMID:40605065).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 1992 High

    Established that the N-myristoyltransferase is an essential monomeric enzyme with a defined catalytic core and an N-terminal targeting region, answering what minimal structure supports myristoyl transfer.

    Evidence Deletion mutagenesis of yeast Nmt1p in E. coli co-expression with in vitro [3H]myristate assays and rescue of an nmt1 null allele

    PMID:1429724

    Open questions at the time
    • Defined in yeast ortholog rather than human NMT1
    • Does not resolve atomic-level catalytic mechanism
  2. 1992 High

    Mapped how substrate specificity is encoded, showing functional peptide- and acyl-CoA-binding sites require both enzyme halves and explaining species-specific substrate recognition.

    Evidence Chimeric human/yeast NMT constructs co-expressed with G-protein alpha substrates and assayed by [3H]myristate incorporation

    PMID:1429724

    Open questions at the time
    • Specificity elements mapped by chimeras, not full structure
    • Limited to a small set of test substrates
  3. 1998 High

    Demonstrated NMT essentiality for viability in a pathogen and validated it as a druggable antifungal target, establishing the enzyme as therapeutically tractable.

    Evidence Conditional-lethal NMT allele in Cryptococcus neoformans with human NMT rescue and purified-enzyme inhibitor kinetics

    PMID:9575206

    Open questions at the time
    • Demonstrated in fungal system
    • Human NMT inhibition shown only kinetically, not in cells
  4. 2022 High

    Resolved the chemical basis for dual glycine versus lysine myristoylation, explaining why N-terminal glycine modification dominates while lysine modification is rare and post-translational.

    Evidence Crystallography combined with in vitro kinetics, mass spectrometry, and in silico motif analysis

    PMID:36181773

    Open questions at the time
    • Biological scope of K-myristoylation in cells not defined
    • Specific human substrates not enumerated here
  5. 2018 Medium

    Placed NMT1 within an oxidative/ER-stress and JNK-autophagy axis, defining a tumor-suppressive consequence of NMT1 loss in breast cancer.

    Evidence NMT1 knockdown in breast cancer lines with ROS measurement, JNK western blotting, autophagy assays, and xenografts

    PMID:30446635

    Open questions at the time
    • Direct myristoylation substrate driving the phenotype not identified
    • Single lab
  6. 2021 Medium

    Showed NMT1 myristoylation bidirectionally controls substrate stability via E3-ligase-mediated ubiquitination, distinguishing destabilized from stabilized target classes in liver cancer.

    Evidence Liver-conditional NMT1 knockout mice with iTRAQ proteomics, click chemistry, PRM, co-IP, and ubiquitination assays

    PMID:34136404

    Open questions at the time
    • Mechanism by which myristoylation directs opposite ubiquitination outcomes unclear
    • POTEE/HBB roles not structurally defined
  7. 2023 High

    Identified VILIP3 as an NMT1 substrate and pinned the drug-binding site at Asn-246, connecting catalytic inhibition to NFκB/Bcl-2 signaling and providing a defined pharmacophore.

    Evidence DARTS and SPR target identification, metabolic labeling MS for substrate, and NMT1 perturbation across CDX/PDO/PDX models

    PMID:36617552

    Open questions at the time
    • Direct link from VILIP3 myristoylation to NFκB mechanism not fully resolved
    • Selectivity of desloratadine over NMT2 not addressed
  8. 2023 Medium

    Defined NMT1 as a stabilizer of ICAM-1 by inhibiting the E3 ligase FBXO4, linking myristoylation to cell adhesion and migration control.

    Evidence NMT1 knockdown with co-IP, ubiquitination, half-life, and migration/adhesion assays

    PMID:37269961

    Open questions at the time
    • Whether NMT1 inhibits FBXO4 directly or via myristoylation unclear
    • Single lab
  9. 2024 Medium

    Identified Sorbs2 as an NMT1-binding partner that suppresses global myristoylation under TNF-α, revealing inflammatory regulation of NMT1 activity in osteoblasts.

    Evidence Click-it myristoylation assay, RNAi, immunoprecipitation, and mass spectrometry in MC3T3-E1 cells

    PMID:38148048

    Open questions at the time
    • Molecular mechanism by which Sorbs2 inhibits NMT1 not defined
    • Single lab and single cell model
  10. 2025 High

    Showed NMT1 myristoylates TMEM106B at both glycine-2 and lysine-3, controlling its lysosomal degradation, fragment generation, and surface-versus-lysosome trafficking.

    Evidence NMT1/2 enzymatic assays with G2A/K3 mutants, subcellular fractionation, live imaging, and lysosomal inhibitor experiments

    PMID:40451428

    Open questions at the time
    • Relative in vivo contributions of NMT1 versus NMT2 not separated
    • Disease relevance of TMEM106B fragments not tested here
  11. 2025 Medium

    Connected HIF1α-driven NMT1 to CHP1 myristoylation and PD-L1 membrane trafficking, defining a hypoxia-induced immune-evasion mechanism druggable by PCLX-001.

    Evidence PCLX-001 treatment, HIF1α perturbation, CHP1/PD-L1 co-IP, flow cytometry for PD-L1, and xenografts

    PMID:40605065

    Open questions at the time
    • Direct structural basis of myristoylated-CHP1–PD-L1 interaction unresolved
    • Single lab
  12. 2025 Medium

    Defined an NMT1/myristic-acid/VPS15 axis in cerebral ischemia, showing NMT1 loss raises myristic acid and lowers VPS15 to worsen injury.

    Evidence NMT1 knockdown in rat ischemia-reperfusion model with MA injection, BCtDCS modulation, and infarct measurement

    PMID:40221008

    Open questions at the time
    • Mechanism linking myristic acid accumulation to VPS15 downregulation unclear
    • Single in vivo model
  13. 2024 Medium

    Established host NMT1/NMT2 as required for mammarenavirus replication by myristoylating viral Z and SSP proteins, nominating NMT inhibition as a broad antiviral strategy.

    Evidence Pan-NMT inhibitor DDD85464, G2A mutation of Z/SSP, budding and fusion assays, and proteasome rescue (preprint)

    Open questions at the time
    • Preprint, not yet peer-reviewed
    • NMT1-specific versus NMT2-specific contributions not separated

Open questions

Synthesis pass · forward-looking unresolved questions
  • How NMT1 substrate selection, dual G/K modification, and downstream trafficking/stability outcomes are coordinated in a single cellular context, and how NMT1 is distinguished functionally from NMT2, remains unresolved.
  • No unifying model linking substrate choice to opposite stability outcomes
  • NMT1 vs NMT2 substrate division of labor undefined
  • No human structure-guided substrate prediction validated in cells

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016740 transferase activity 4 GO:0140096 catalytic activity, acting on a protein 2 GO:0016874 ligase activity 1
Localization
GO:0005829 cytosol 1
Pathway
R-HSA-1643685 Disease 3 R-HSA-392499 Metabolism of proteins 3 R-HSA-168256 Immune System 1 R-HSA-9612973 Autophagy 1
Partners
CHP1FBXO4ICAM-1PD-L1SORBS2TMEM106BVILIP3

Evidence

Reading pass · 13 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1992 Saccharomyces cerevisiae Nmt1p (NMT1 ortholog) is an essential, monomeric 455-residue enzyme whose minimal catalytic domain lies between Ile59–Phe96 and Gly451–Leu455, as determined by deletion mutagenesis. The amino-terminal 59 residues play a non-catalytic targeting role, allowing the cytosolic enzyme to access myristoyl-CoA pools derived from exogenous fatty acid activation by acyl-CoA synthetases. Deletion mutagenesis of Nmt1p expressed in E. coli co-expression system; in vitro enzyme assay with [3H]myristate incorporation; rescue of nmt1 null allele in yeast The Journal of biological chemistry High 1429724
1992 Structural elements determining substrate specificity differences between yeast Nmt1p and human NMT were mapped using chimeric enzymes: recognition of the human-specific substrate Gz-alpha involves elements distributed from the amino-terminal half through the region Leu352–Lys410 of the 416-residue human enzyme, and formation of fully functional peptide- and myristoyl-CoA-binding sites requires contributions from both amino- and carboxyl-terminal halves of either enzyme. E. coli co-expression of chimeric human/yeast NMT constructs with substrate G-protein alpha subunits; [3H]myristate incorporation assay The Journal of biological chemistry High 1429724
1998 Cryptococcus neoformans NMT (Nmt) is essential for fungal viability; under-myristoylation of an ADP ribosylation factor (Arf) substrate contributes to a temperature-sensitive myristic acid auxotrophy phenotype caused by a conditional-lethal nmt allele. A depeptidized inhibitor exerted fungicidal effects in an Nmt-dependent manner, with Ki(app) of 1.8 µM for fungal Nmt and 9 µM for human NMT. Homologous recombination to introduce conditional-lethal NMT allele; isogenic strain comparison with human NMT rescue; kinetic inhibition studies with purified fungal and human Nmt; protein synthesis inhibition assays The Journal of biological chemistry High 9575206
2022 NMT (N-myristoyltransferase) catalyzes both G-myristoylation (N-terminal glycine α-amino group) and K-myristoylation (lysine ε-amino group). Crystal structure and kinetic studies show that K-myristoylation uses direct interactions between the substrate's reactive amino group and the NMT catalytic base, whereas G-myristoylation uses a water-mediated interaction, making G-myristoylation more efficient. K-myristoylation motifs are depleted in humans, suggesting evolutionary pressure against it, and K-myristoylation arises only from post-translational events. Crystallography, mass spectrometry, in vitro kinetic assays, in silico analysis Journal of molecular biology High 36181773
2023 NMT1 myristoylates VILIP3 (Visinin-like protein 3) as a substrate. Desloratadine binds to Asn-246 in NMT1 and inhibits its enzymatic activity, blocking NMT1-mediated myristoylation of VILIP3 and disrupting downstream NFκB/Bcl-2 signaling in hepatocellular carcinoma cells. Drug affinity responsive target stability (DARTS) and surface plasmon resonance (SPR) to identify NMT1 as desloratadine target; metabolic labeling and mass spectrometry to identify VILIP3 as NMT1 substrate; NMT1 knockdown and overexpression in vitro and in vivo (CDX, PDO, PDX models) Signal transduction and targeted therapy High 36617552
2018 Genetic inhibition of NMT1 in breast cancer cells promotes oxidative stress (ROS) and ER stress, which cross-talk with mitochondria to produce more ROS; both stresses activate the JNK pathway, leading to autophagy that suppresses breast cancer progression. ROS negatively regulates NMT1 expression and NMT1 knockdown conversely promotes oxidative stress, forming a feedback loop. NMT1 knockdown (siRNA/shRNA) in breast cancer cell lines; in vitro proliferation/invasion assays; in vivo xenograft models; ROS measurements; JNK pathway western blotting; autophagy assays Cell death & disease Medium 30446635
2021 NMT1-mediated N-myristoylation differentially regulates two categories of protein targets in liver cancer: NDP proteins (LXN, RPL29, FAU) are N-myristoylated by NMT1 in a POTEE-dependent manner causing their destabilization via RPL7A/HIST1H4H ubiquitin E3 ligase-mediated ubiquitination, whereas NUP proteins (AHSG, ALB, TF) are N-myristoylated by NMT1, increasing their stability by preventing ubiquitination through HBB. Both RPL7A and HBB functions are NMT1-dependent. Liver-conditional NMT1 knockout mice; iTRAQ proteomics; click chemistry assay for N-myristoylation levels; parallel reaction monitoring (PRM); co-immunoprecipitation; ubiquitination assays Frontiers in oncology Medium 34136404
2023 NMT1 sustains ICAM-1 protein levels by preventing its ubiquitination and proteasomal degradation; mechanistically, NMT1 myristoylates the N-terminus of ICAM-1 and inhibits the Ub E3 ligase F-box protein 4 (FBXO4), prolonging the half-life of ICAM-1 protein and thereby sustaining cell adhesion while suppressing tumor cell migration. NMT1 knockdown; co-immunoprecipitation; ubiquitination assays; half-life assays; migration/adhesion functional assays Cellular signalling Medium 37269961
2024 TNF-α stimulation in osteoblasts (MC3T3-E1 cells) increases NMT1 expression but inhibits overall protein myristoylation; immunoprecipitation and mass spectrometry identified Sorbs2 as a novel NMT1-binding protein, and the NMT1–Sorbs2 interaction upon TNF-α stimulation is responsible for inhibition of myristoylation. Click-it assay for myristoylated proteins; RNA interference; mass spectrometry; immunoprecipitation; immunocytochemistry; western blotting In vivo (Athens, Greece) Medium 38148048
2025 NMT1 myristoylates TMEM106B at its glycine-2 α-amino group and lysine-3 ε-amino group. Myristoylation promotes lysosomal degradation of TMEM106B, regulates generation of its C-terminal fragments, and controls its trafficking: non-myristoylated TMEM106B accumulates on the cell surface instead of being trafficked to lysosomes. NMT1/2 enzymatic assays; site-directed mutagenesis (G2A, K3 mutants); subcellular fractionation; live cell imaging; lysosomal inhibitor experiments; western blotting for TMEM106B levels and CTFs The Journal of biological chemistry High 40451428
2025 HIF1α upregulates NMT1, which mediates myristoylation of calcineurin B homologous protein 1 (CHP1) under hypoxia. Myristoylated CHP1 binds PD-L1 and facilitates its rapid translocation to the cell membrane, enhancing PD-L1-mediated immune evasion. The NMT1 inhibitor PCLX-001 blocks CHP1 myristoylation, disrupting excessive PD-L1 membrane localization. NMT1 inhibitor (PCLX-001) treatment; HIF1α overexpression/knockdown; co-immunoprecipitation of CHP1 and PD-L1; flow cytometry for PD-L1 membrane localization; xenograft mouse models Journal of experimental & clinical cancer research : CR Medium 40605065
2025 NMT1 downregulation in cerebral ischemia leads to accumulation of myristic acid (MA) in the penumbra, which in turn reduces VPS15 (phosphoinositide 3-kinase regulatory subunit 4) expression, exacerbating ischemia injury. NMT1 thus acts on MA to regulate VPS15 expression, defining an NMT1/MA/VPS15 signaling pathway. NMT1 knockdown in rat cerebral ischemia-reperfusion model; intraperitoneal MA injection; BCtDCS to modulate MA levels; western blotting for NMT1 and VPS15; infarct volume measurement Experimental neurology Medium 40221008
2024 Host cell NMT1 (and NMT2) are required for mammarenavirus multiplication: the validated pan-NMT inhibitor DDD85464 exerts antiviral activity against LCMV, JUNV, and LASV, correlating with reduced Z protein budding activity, reduced GP2-mediated fusion activity, and proteasome-mediated degradation of the Z protein. The Z protein and stable signal peptide (SSP) of mammarenaviruses are N-terminally myristoylated by host NMT1/NMT2. Pan-NMT inhibitor DDD85464 treatment; G2A mutation analysis of viral Z and SSP proteins; virus budding assays; GP2-mediated fusion assays; proteasome inhibitor rescue experiments bioRxivpreprint Medium

Source papers

Stage 0 corpus · 42 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1990 nmt1 of fission yeast. A highly transcribed gene completely repressed by thiamine. The Journal of biological chemistry 752 2358444
1993 TATA box mutations in the Schizosaccharomyces pombe nmt1 promoter affect transcription efficiency but not the transcription start point or thiamine repressibility. Gene 619 8422997
1992 Comparative analysis of the beta transducin family with identification of several new members including PWP1, a nonessential gene of Saccharomyces cerevisiae that is divergently transcribed from NMT1. Proteins 100 1594577
2003 Prediction of lipid posttranslational modifications and localization signals from protein sequences: big-Pi, NMT and PTS1. Nucleic acids research 73 12824382
2023 Blockade of NMT1 enzymatic activity inhibits N-myristoylation of VILIP3 protein and suppresses liver cancer progression. Signal transduction and targeted therapy 63 36617552
1992 Studies of the catalytic activities and substrate specificities of Saccharomyces cerevisiae myristoyl-coenzyme A: protein N-myristoyltransferase deletion mutants and human/yeast Nmt chimeras in Escherichia coli and S. cerevisiae. The Journal of biological chemistry 49 1429724
2021 Plasticity in Neuroblastoma Cell Identity Defines a Noradrenergic-to-Mesenchymal Transition (NMT). Cancers 47 34200747
2018 NMT1 inhibition modulates breast cancer progression through stress-triggered JNK pathway. Cell death & disease 37 30446635
1998 Genetic and biochemical studies establish that the fungicidal effect of a fully depeptidized inhibitor of Cryptococcus neoformans myristoyl-CoA:protein N-myristoyltransferase (Nmt) is Nmt-dependent. The Journal of biological chemistry 37 9575206
1987 Characterization of a novel N-methyltransferase (NMT) from Catharanthus roseus plants : Detection of NMT and other enzymes of the indole alkaloid biosynthetic pathway in different cell suspension culture systems. Plant cell reports 31 24248932
1998 Nascent transcription from the nmt1 and nmt2 genes of Schizosaccharomyces pombe overlaps neighbouring genes. The EMBO journal 28 9606189
1996 A radioresistant variant cell line, NMT-1R, isolated from a radiosensitive rat yolk sac tumour cell line, NMT-1: differences of early radiation-induced morphological changes, especially apoptosis. International journal of radiation biology 27 8613682
1994 nmt2 of fission yeast: a second thiamine-repressible gene co-ordinately regulated with nmt1. Yeast (Chichester, England) 23 7992507
1994 ntf1+ encodes a 6-cysteine zinc finger-containing transcription factor that regulates the nmt1 promoter in fission yeast. The Journal of biological chemistry 19 8163491
2018 NMT1 and NMT3 N-Methyltransferase Activity Is Critical to Lipid Homeostasis, Morphogenesis, and Reproduction. Plant physiology 18 29777000
1993 Establishment and characterization of a rat yolk sac tumor cell line, NMT-1, producing alpha-fetoprotein, with potential for lymphatic metastasis. Japanese journal of cancer research : Gann 15 7507475
2021 N-Myristoylation by NMT1 Is POTEE-Dependent to Stimulate Liver Tumorigenesis via Differentially Regulating Ubiquitination of Targets. Frontiers in oncology 12 34136404
2022 Structural and Large-scale Analysis Unveil the Intertwined Paths Promoting NMT-catalyzed Lysine and Glycine Myristoylation. Journal of molecular biology 10 36181773
2021 QSAR and Pharmacophore Modeling of Nitrogen Heterocycles as Potent Human N-Myristoyltransferase (Hs-NMT) Inhibitors. Molecules (Basel, Switzerland) 10 33805223
2011 A chemical compound for controlled expression of nmt1-driven gene in the fission yeast Schizosaccharomyces pombe. Analytical biochemistry 10 21295003
2003 Characterization and expression of the Neurospora crassa nmt-1 gene. Current genetics 10 13680155
1999 Expression of enzymes of covalent protein modification during regulated and dysregulated proliferation of mammary epithelial cells: PKA, PKC and NMT. Advances in enzyme regulation 9 10470373
2023 NMT1 sustains ICAM-1 to modulate adhesion and migration of tumor cells. Cellular signalling 7 37269961
2015 An IPTG-inducible derivative of the fission yeast nmt promoter. Yeast (Chichester, England) 7 25801050
2023 Mechanism of Ligand Discrimination by the NMT1 Riboswitch. Journal of chemical information and modeling 6 37486304
2021 Long noncoding RNA ANCR promotes migration, invasion, EMT progress and stemness of nasopharyngeal carcinoma cells via the miR-4731-5p/NMT1 axis. Pathology, research and practice 6 34333213
2019 Regulation of the thiamine pyrophosphate (TPP)-sensing riboswitch in NMT1 mRNA from Neurospora crassa. FEBS letters 6 31664711
1995 An 8.2 kb DNA segment from chromosome XIV carries the RPD3 and PAS8 genes as well as the Saccharomyces cerevisiae homologue of the thiamine-repressed nmt1 gene and a chromosome III-duplicated gene for a putative aryl-alcohol dehydrogenase. Yeast (Chichester, England) 6 8533474
2022 Identification of potential inhibitors for N-myristoyltransferase (NMT) protein of Plasmodium vivax. Journal of biomolecular structure & dynamics 5 36002266
2006 Joint regulation of the nmt1 promoter and sporulation by Thi1 and Thi5 in Schizosaccharomyces pombe. Current genetics 5 16874521
2025 Elucidating the role of N-myristoylation in the excessive membrane localization of PD-L1 in hypoxic cancers and developing a novel NMT1 inhibitor for combination with immune checkpoint blockade therapy. Journal of experimental & clinical cancer research : CR 3 40605065
2022 NMT1 Enhances the Stemness of NSCLC Cells by Activating the PI3K/AKT Pathway. Pharmacology 3 35732157
2021 The role of NMT induction on odontogenic proliferation and differentiation of dental pulp stem cells. Heliyon 3 33937538
2025 Myristoylation of TMEM106B by NMT1/2 regulates TMEM106B trafficking and turnover. The Journal of biological chemistry 2 40451428
2025 Molecular docking and simulation analysis of selected herbal compounds against GP63, FPPS, and NMT, three important Leishmania major proteins. Research in pharmaceutical sciences 1 40933604
2024 TNF-α-induced Inhibition of Protein Myristoylation Via Binding Between NMT1 and Sorbs2 in Osteoblasts. In vivo (Athens, Greece) 1 38148048
2024 Development of a genetically encoded NMT indicator for detection of mercury ions based on the green fluorescent protein mNeonGreen and metallothionein II from rat liver. Heliyon 1 38975119
2022 Inspection of in-house designed novel thiochromone amino-acid conjugate derivatives as Lm-NMT inhibitor - An in-silico analysis. Journal of molecular graphics & modelling 1 36542915
2019 N-Myristoyl Transferase (NMT)-Catalyzed Labeling of Bacterial Proteins for Imaging in Fixed and Live Cells. Methods in molecular biology (Clifton, N.J.) 1 31161515
2025 Identification of NMT1/MA/VPS15 signal pathway as potential therapeutic target in rat cerebral ischemia injury. Experimental neurology 0 40221008
2025 Mitigating cadmium toxicity in rice through tandem application of zinc oxide nanoparticles and Serendipita indica as revealed by multi-omics and NMT-based ion flux analysis. Journal of hazardous materials 0 41406521
2014 The crystal structure of pyrimidine/thiamin biosynthesis precursor-like domain-containing protein CAE31940 from proteobacterium Bordetella bronchiseptica RB50, and evolutionary insight into the NMT1/THI5 family. Journal of structural and functional genomics 0 24908050

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