Affinage

NEDD9

Enhancer of filamentation 1 · UniProt Q14511

Length
834 aa
Mass
92.9 kDa
Annotated
2026-06-10
100 papers in source corpus 48 papers cited in narrative 48 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

NEDD9 (HEF1/Cas-L) is a multi-domain Cas-family scaffolding protein that assembles tyrosine-phosphorylation–dependent signaling complexes to control cell adhesion, migration, invasion, and mitotic/ciliary progression (PMID:8879209, PMID:19738060). At focal adhesions it is tyrosine-phosphorylated upon β1 integrin ligation and engages FAK and the adaptor Crk/CrkL, also recruiting Nck, SHPTP2, and Pyk2/RAFTK, with FAK acting upstream in a linear integrin–FAK–HEF1 effector pathway that drives lymphocyte and tumor cell migration (PMID:8879209, PMID:9162067, PMID:9020138, PMID:11465098). The same phosphorylation module is engaged downstream of TCR/BCR, the calcitonin GPCR, and the oncogenic kinases BCR-ABL and Src, channeling signals to Crk/C3G and Rap1-dependent adhesion and chemotaxis (PMID:9497377, PMID:9405482, PMID:10455189, PMID:22810897). As a downstream effector NEDD9 supports activation of FAK, Src, AKT and ERK and stabilizes focal adhesions, while promoting mesenchymal invasion through integrin β3/Src/ROCK signaling and through control of MMP14/MMP9 protease activity—the latter via direct binding to ARAP3 and GGA3 to drive Arf6-dependent endosomal trafficking of the MMP14/TIMP2 complex (PMID:19738060, PMID:22509381, PMID:22328516, PMID:25241893, PMID:29876004). At the centrosome and primary cilium NEDD9 binds and activates Aurora A kinase, an interaction that stabilizes Aurora A by limiting CDH1-APC/C–mediated ubiquitination and drives HDAC6-dependent tubulin/cortactin deacetylation to promote ciliary disassembly and mitotic progression (PMID:16184168, PMID:17604723, PMID:23539442, PMID:24574519). NEDD9 additionally regulates the RhoA–ECT2 cycle during cytokinesis and is cleaved by caspases during mitosis and apoptosis into subcellularly targeted fragments (PMID:16394104, PMID:9584194, PMID:10866674). NEDD9 abundance is set transcriptionally by Wnt/β-catenin, retinoic acid, AhR, and LKB1–CRTC1 inputs and post-translationally by proteasomal degradation controlled by Smad3/APC/C-CDH1 and by Smurf2 (PMID:21317929, PMID:18585997, PMID:23074285, PMID:11118211, PMID:15144564, PMID:20825672). Oxidation of Cys18 in the SMAD3 docking region stabilizes NEDD9 and reroutes it into an NKX2-5/COL3A1 transcriptional program driving fibrotic pulmonary vascular remodeling, and NEDD9 mediates platelet–endothelial adhesion via P-selectin, establishing causative roles in pulmonary hypertension and thromboembolic remodeling (PMID:29899023, PMID:33523764).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 1996 High

    Established NEDD9 as an integrin-responsive adaptor by showing it is tyrosine-phosphorylated upon β1 integrin ligation and directly binds FAK and Crk, defining its core scaffolding logic at adhesion sites.

    Evidence Immunoprecipitation, in vitro binding, and cloning in T lymphocytes

    PMID:8879209

    Open questions at the time
    • Did not define the kinase directly phosphorylating NEDD9
    • No structural detail of binding interfaces
  2. 1997 Medium

    Showed the integrin-driven phosphorylation module is shared across hematopoietic receptors and oncogenic kinases, recruiting CrkL, Pyk2 and forming complexes downstream of BCR/ABL and BCR ligation.

    Evidence Co-IP with SH2-domain specificity in lymphoid and leukemic cells, including transgenic leukemic tissue

    PMID:9020138 PMID:9162067 PMID:9405482

    Open questions at the time
    • Functional consequence of distinct CrkL complexes not resolved
    • Single-method complex identification in some contexts
  3. 1998 High

    Defined receptor-specific wiring (TCR vs integrin) and revealed cell-cycle-coupled caspase processing, showing full-length NEDD9 at focal adhesions and a p55 fragment at the mitotic spindle.

    Evidence SH3-deletion mutants, synchronized-cell Western blots, fractionation/IF, caspase inhibitors, yeast two-hybrid

    PMID:9497377 PMID:9584194

    Open questions at the time
    • Protease responsible for mitotic cleavage not identified
    • Functional role of p55 at the spindle untested
  4. 2000 High

    Connected NEDD9 to apoptosis and to TGF-β/Smad3 negative feedback, and identified GPCR and GEF (AND-34) inputs, broadening its signaling and turnover control.

    Evidence Inducible overexpression with caspase inhibitors, Co-IP, proteasome inhibitors, GTPase pulldowns

    PMID:10692442 PMID:10866674 PMID:10954702 PMID:11118211

    Open questions at the time
    • E3 ligase mediating Smad3-directed degradation not yet identified
    • Apoptotic fragment mechanism partially defined
  5. 2001 Medium

    Demonstrated adhesion-state control of NEDD9 stability and a focal adhesion targeting domain required for spreading, and placed NEDD9 in a linear integrin–FAK–HEF1 migration pathway.

    Evidence Detachment/attachment assays, FAK site-specific mutants, deletion mutants, migration assays

    PMID:11438665 PMID:11465098

    Open questions at the time
    • Identity of detachment-activated protease unclear
    • Mechanism linking FAK autophosphorylation to NEDD9 phosphorylation not fully resolved
  6. 2002 Medium

    Linked NEDD9 to invasive output by showing it enhances migration via ERK/p38 and upregulates metalloproteinases and contractility genes, and is transcriptionally induced by TGF-β1.

    Evidence Inducible expression, haptotaxis assays, kinase inhibitors, cDNA arrays, Src inhibitor PP1

    PMID:11801728 PMID:12189134

    Open questions at the time
    • Direct vs indirect transcriptional effects not distinguished
    • Single-lab profiling
  7. 2005 High

    Identified the centrosomal NEDD9–Aurora A axis controlling spindle and centrosome behavior, and refined Smad3-directed turnover to the APC/C-CDH1 ligase.

    Evidence Co-IP, siRNA/overexpression with centrosome/spindle phenotypes, domain mapping

    PMID:15144564 PMID:15592516 PMID:16184168

    Open questions at the time
    • Mechanism of Aurora A activation by NEDD9 not yet defined at 2005
    • HTLV-I Tax interaction physiological relevance limited
  8. 2006 High

    Extended NEDD9 mitotic function to RhoA–ECT2 regulation during cytokinesis and confirmed it as a selective FAK effector in tumor invasion and melanoma metastasis.

    Evidence siRNA/overexpression, RhoA activity assays, Co-IP with ECT2, in vitro/in vivo invasion and metastasis models

    PMID:16288224 PMID:16394104 PMID:16814714

    Open questions at the time
    • How NEDD9 modulates ECT2/RhoA GEF activity biochemically unresolved
    • Selectivity over p130CAS mechanistically unexplained
  9. 2007 High

    Resolved the cilia connection, showing NEDD9–Aurora A activation triggers HDAC6 to drive ciliary disassembly, a nonmitotic Aurora A function.

    Evidence Co-IP, AurA/HDAC6 inhibitors, loss/gain of function with ciliary resorption readout

    PMID:17604723

    Open questions at the time
    • Stoichiometry of the NEDD9–AurA–HDAC6 module not defined
    • Upstream cue triggering complex assembly at the basal body unclear
  10. 2010 Medium

    Established NEDD9 stability is positively controlled by Smurf2 and tied the AurA/cilia axis to VHL-HIF, while a knockout model confirmed NEDD9 as a scaffold supporting AKT/Src/FAK/ERK.

    Evidence Co-IP, ubiquitination assays, VHL re-expression/HIF stabilization, MMTV-PyVT Nedd9-null model

    PMID:19738060 PMID:20825672 PMID:20864688

    Open questions at the time
    • Opposing roles of Smurf2 vs APC/C in NEDD9 turnover not reconciled
    • Direct vs indirect kinase support in vivo unresolved
  11. 2013 High

    Provided the molecular basis of NEDD9-mediated Aurora A control, showing binding stabilizes Aurora A by blocking CDH1-APC/C ubiquitination, with S296 governing the interaction.

    Evidence Co-IP, ubiquitination assays, S296E mutant, proteasome inhibitors, shRNA/re-expression

    PMID:23539442

    Open questions at the time
    • How S296 phosphorylation is regulated in cells not defined
    • Structural model of the NEDD9–AurA interface absent
  12. 2014 High

    Defined the effector arm of NEDD9-driven invasion: cortactin deacetylation via AurA/HDAC6 for lamellipodia, and Arf6/ARAP3/GGA3-dependent endosomal routing of MMP14/TIMP2 to license proteolysis.

    Evidence Co-IP, acetylation/deacetylation assays, mutant rescue, Arf6 activity assays, trafficking imaging, xenografts

    PMID:24202705 PMID:24574519 PMID:25139996 PMID:25241893

    Open questions at the time
    • Coordination between cilia/centrosome and invasion functions unclear
    • Direct binding topology on ARAP3/GGA3 not structurally mapped
  13. 2018 High

    Identified a redox switch (Cys18 oxidation) that disables Smad3 docking, stabilizing NEDD9 and rerouting it to an NKX2-5/COL3A1 program, establishing causation in fibrotic pulmonary vascular remodeling.

    Evidence Microscale thermophoresis, oxidant-stress models, Co-IP, ChIP, NEDD9 knockout PAH models

    PMID:29899023

    Open questions at the time
    • In vivo extent of Cys18 oxidation under disease conditions not quantified
    • How NEDD9 selects NKX2-5 over other partners unclear
  14. 2021 Medium

    Revealed an extracellular adhesion function: surface NEDD9 binds P-selectin to mediate platelet–endothelial adhesion under hypoxia, suggesting a therapeutic target in thromboembolic remodeling.

    Evidence Network proteomics, MST binding, NEDD9-/- mice, anti-NEDD9 antibody, CTEPH patient cells

    PMID:33523764

    Open questions at the time
    • Mechanism of NEDD9 surface display for an adaptor protein unresolved
    • Single-lab new mechanism awaiting independent confirmation

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the distinct NEDD9 pools (focal adhesion, centrosome/cilium, endosomal trafficking, cell-surface adhesion) are spatially and temporally partitioned within a single cell, and how its phosphorylation and degradation states select among partners, remains unresolved.
  • No structural model of full-length NEDD9 with partners
  • Quantitative rules governing partner selection by phospho-state unknown
  • Integration of mitotic and migratory functions in vivo undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 3 GO:0098772 molecular function regulator activity 2 GO:0098631 cell adhesion mediator activity 1
Localization
GO:0005815 microtubule organizing center 3 GO:0005929 cilium 3 GO:0005768 endosome 1 GO:0005886 plasma membrane 1
Pathway
R-HSA-1474244 Extracellular matrix organization 3 R-HSA-162582 Signal Transduction 3 R-HSA-1640170 Cell Cycle 3 R-HSA-168256 Immune System 3 R-HSA-1643685 Disease 2 R-HSA-9609507 Protein localization 1
Partners
ARAP3AURKACRKLCTTNECT2GGA3PTK2/FAKSMAD3
Complex memberships
NEDD9–Aurora A centrosomal complexfocal adhesion

Evidence

Reading pass · 48 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2007 HEF1/NEDD9 interacts with Aurora A kinase at the basal body of cilia, leading to Aurora A activation, which in turn phosphorylates and activates HDAC6 (a tubulin deacetylase), thereby promoting ciliary disassembly. This constitutes a nonmitotic activity of Aurora A in vertebrates. Co-immunoprecipitation, small molecule inhibitors of AurA and HDAC6, loss-of-function and overexpression experiments with defined ciliary resorption phenotype Cell High 17604723
2005 HEF1/NEDD9 associates with and activates Aurora A (AurA) kinase at the centrosome; overexpression causes increased centrosome numbers and multipolar spindles. Depletion causes centrosomal splitting, mono-astral spindles, and hyperactivation of Nek2, indicating HEF1 also acts earlier in the cell cycle. Co-immunoprecipitation, overexpression and siRNA knockdown with centrosome/spindle phenotype readouts Nature cell biology High 16184168
2006 NEDD9 functionally interacts with focal adhesion kinase (FAK) and modulates focal contact formation to enhance melanocyte invasion in vitro and metastasis in vivo. Biochemical co-immunoprecipitation, in vitro invasion assays, in vivo metastasis model, focal contact imaging Cell High 16814714
1996 Cas-L/NEDD9 (pp105) is tyrosine-phosphorylated upon β1 integrin ligation in T lymphocytes and directly binds both FAK and the adaptor Crk; it also recruits Nck and SHPTP2 upon integrin engagement. Immunoprecipitation, in vitro binding assay, peptide sequencing/cloning The Journal of experimental medicine High 8879209
1998 HEF1/NEDD9 is processed from full-length p115/p105 forms into a p55 amino-terminal fragment via caspase cleavage specifically at mitosis; p55 localizes to the mitotic spindle. Full-length forms localize to focal adhesions. HEF1 expression is cell-cycle regulated, upregulated upon growth induction. Two-hybrid screening identified the human homolog of G2/M regulator Dim1p as a p55-region interactor. Western blotting of synchronized cells, subcellular fractionation/immunofluorescence, yeast two-hybrid screen, caspase inhibitor experiments Molecular and cellular biology High 9584194
2000 Smad3 physically interacts with HEF1/NEDD9 and triggers its proteasomal degradation; TGF-β stimulation induces rapid proteasomal degradation of endogenous HEF1 in TGF-β-responsive cells. Elevated HEF1 in turn inhibits TGF-β/Smad3-mediated gene responses, suggesting a negative feedback mechanism. Co-immunoprecipitation, overexpression degradation assays, proteasome inhibitor experiments, TGF-β stimulation of endogenous protein The EMBO journal High 11118211
2004 Smad3 recruits the APC/C ubiquitin ligase to HEF1/NEDD9 for proteasomal degradation: Smad3 directly contacts APC subunit APC10 via distinct MH2 subdomains, while HEF1 is recognized as a ubiquitination substrate by the CDH1 subunit of APC/C. Co-immunoprecipitation, domain mapping, overexpression degradation assays BMC cell biology Medium 15144564
2000 HEF1/NEDD9 overexpression induces apoptosis; caspase-dependent cleavage generates 65-, 55-, and 28-kDa fragments during apoptosis. The 28-kDa C-terminal fragment drives apoptosis in a manner dependent on a divergent helix-loop-helix motif and the N-terminal 28 amino acids; it also causes cell rounding. HEF1 overexpression activates JNK, which co-localizes with HEF1. Inducible overexpression, caspase inhibitors, deletion/point mutants, immunofluorescence co-localization Molecular and cellular biology High 10866674
2001 HEF1/NEDD9 undergoes proteolytic processing specifically in response to cell detachment; integrin receptor ligation and focal adhesion formation prevent this cleavage. A novel focal adhesion targeting domain in the HEF1 C-terminus is required for HEF1-induced cell spreading. Cell detachment/attachment assays, integrin blocking experiments, deletion mutant overexpression, immunofluorescence Molecular and cellular biology High 11438665
2002 HEF1/NEDD9 inducible expression enhances cell speed and haptotaxis toward fibronectin in a manner partially dependent on ERK and p38 MAPK signaling pathways. HEF1 upregulates mRNAs encoding metalloproteinases, MLCK, p160ROCK, and ErbB2. Inducible expression system, cell migration/haptotaxis assays, kinase inhibitors, cDNA expression array Journal of cell science Medium 11801728
2006 HEF1/NEDD9 regulates the RhoA activation cycle during mitosis: increased HEF1 sustains RhoA activation causing failure at cytokinesis, while HEF1 depletion reduces RhoA activation causing defects before cleavage furrow formation. HEF1 associates with the RhoA-GEF ECT2. siRNA knockdown, overexpression, RhoA activity assays, Co-immunoprecipitation with ECT2, chemical RhoA inhibition rescue Molecular biology of the cell High 16394104
2001 FAK regulates β1 integrin-dependent T cell migration through a linear β1 integrin–FAK–HEF1 effector pathway: FAK autophosphorylation and its PR1/HEF1-SH3-binding sites are required for FAK-driven migration and HEF1 tyrosine phosphorylation upon β1 integrin stimulation. Overexpression of wild-type and site-specific FAK mutants, siRNA, migration assays, phosphorylation analysis European journal of immunology Medium 11465098
2006 HEF1/NEDD9 acts as a necessary and specific downstream effector of FAK in glioblastoma cell migration and invasion: FAK overexpression increases HEF1 phosphorylation; siRNA knockdown of HEF1 (but not p130CAS) inhibits basal and PDGF-stimulated migration and invasion. siRNA knockdown, overexpression, FAK mutants (397F), transwell migration/invasion assays, Triton X-100 fractionation Oncogene Medium 16288224
1997 HEF1/NEDD9 (p110HEF1) is tyrosine phosphorylated upon β1 integrin ligation in lymphoid cells and associates with CRKL via CRKL's SH2 domain; cell-type-specific differential phosphorylation of HEF1 vs. p120CBL determines different downstream CRKL complexes. Co-immunoprecipitation with SH2 domain specificity, anti-integrin stimulation, two cell line comparison The Journal of biological chemistry Medium 9162067
1997 HEF1/NEDD9 is tyrosine phosphorylated downstream of BCR/ABL in leukemic cells and forms a complex with Crkl and P190Bcr/Abl; this occurs specifically for HEF1 (not p130Cas), implicating Bcr/Abl in specific interference with β1 integrin signaling via HEF1. Immunoprecipitation from transgenic mouse leukemic tissues, phosphotyrosine blotting The Journal of biological chemistry Medium 9405482
1997 HEF1/NEDD9 is tyrosine phosphorylated in human B cells upon β1 integrin or BCR ligation in a cytoskeleton-dependent manner; phosphorylated HEF1 associates with RAFTK/Pyk2 and CrkL; cytochalasin B pretreatment blocks both integrin- and BCR-induced HEF1 phosphorylation. Co-immunoprecipitation, cytochalasin B treatment, stimulation of primary and cell line B cells The Journal of biological chemistry Medium 9020138
1998 Cas-L/NEDD9 is transiently phosphorylated upon TCR/CD3 stimulation; phosphorylated Cas-L binds Crk and C3G. A Cas-L mutant lacking the SH3 domain (FAK-binding site) is phosphorylated by CD3 but not β1 integrin stimulation, indicating FAK-independent TCR signaling through Cas-L. CD3 cross-linking, immunoprecipitation, SH3-deletion mutant transfection, phospho-specific blotting The Journal of biological chemistry Medium 9497377
1999 The HEF1/NEDD9 C-terminal domain contains a divergent helix-loop-helix (HLH) motif that mediates HEF1 homodimerization and heterodimerization with Id2, E12, and E47 HLH proteins; this HLH is required for HEF1-induced constitutive pseudohyphal growth in yeast. Yeast two-hybrid interaction assays, deletion/mutation analysis, yeast pseudohyphal growth assay Experimental cell research Medium 10502414
1999 HEF1/NEDD9 (but not p130Cas) is tyrosine phosphorylated downstream of the calcitonin GPCR via Ca2+- and PKC-dependent mechanisms requiring an intact actin cytoskeleton; calcitonin also induces HEF1 association with paxillin and FAK. GPCR stimulation, pharmacological inhibitors (BAPTA, calphostin C, cytochalasin D), Co-immunoprecipitation The Journal of biological chemistry Medium 10455189
2000 Calcitonin-induced tyrosine phosphorylation of HEF1/NEDD9 requires cell attachment to extracellular matrix via integrin engagement, an intact actin cytoskeleton, and c-Src kinase (specifically SH2-competent Src); overexpression of kinase-dead or SH2-lacking Src blocks HEF1 phosphorylation. Erk1/2 phosphorylation by calcitonin is largely independent of these requirements. RGD peptide blocking, poly-D-lysine vs fibronectin adhesion, Src overexpression/mutants, kinase inhibitors The Journal of biological chemistry Medium 10954702
2002 TGF-β1 potently induces HEF1/NEDD9 gene transcription in dermal fibroblasts (16-fold protein increase). The p115 HEF1 isoform results from serine/threonine phosphorylation of p105 HEF1. Adhesion-dependent tyrosine phosphorylation of p105HEF1 is mediated by Src kinase (blocked by PP1 inhibitor), while TGF-β1-induced expression is independent of adhesion. TGF-β1 stimulation, phosphatase digestion, Src inhibitor PP1, in vitro kinase assay The Journal of biological chemistry Medium 12189134
2005 Cell adhesion regulates HEF1/NEDD9 Ser/Thr phosphorylation and proteasomal degradation: actin microfilament disruption activates PP2A which dephosphorylates p115HEF1 to p105HEF1, and the p115 phosphorylated form is preferentially targeted for proteasomal degradation. Adhesion protects HEF1 from degradation. Cell detachment, cytoskeletal inhibitors, PP2A inhibitors, proteasome inhibitors, phosphatase assays Journal of cell science Medium 16352661
2009 In the MMTV-PyVT mammary tumor model, Nedd9-null background reduces activation of AKT, Src, FAK, and ERK in tumor cells. Cell-derived data show persistently reduced FAK activation and adhesion/migration in Nedd9-/- cells, establishing NEDD9 as a scaffolding protein supporting these pro-oncogenic kinases. Genetic knockout mouse model, western blotting of signaling proteins, cell attachment and migration assays Cancer research High 19738060
2013 NEDD9 binding to Aurora A kinase stabilizes AURKA protein by limiting CDH1-APC/C ubiquitin ligase binding to AURKA. NEDD9 S296E mutation disrupts binding to AURKA and leads to reduced AURKA protein levels. NEDD9 depletion increases AURKA ubiquitination and proteasomal degradation. Co-immunoprecipitation, ubiquitination assays, site-directed mutagenesis (S296E), proteasome inhibitor experiments, shRNA knockdown/re-expression Cancer research High 23539442
2010 The WW-HECT E3 ligase Smurf2 physically associates with NEDD9 and is required for NEDD9 protein stability: Smurf2 depletion causes polyubiquitination and proteasomal degradation of NEDD9, while Smurf2 overexpression upregulates NEDD9. The Smurf2/NEDD9 complex is required for Aurora A activation at G2/M and timely mitotic entry. Co-immunoprecipitation, siRNA knockdown, ubiquitination assay, Aurora A activity assays, mitotic entry timing Cell division Medium 20825672
2012 NEDD9 signaling through integrin β3 leads to elevated phosphorylation of integrin β3, increased Src and FAK activity, and decreased ROCK activity (via Src-dependent phosphorylation of ROCKII Tyr722), driving elongated mesenchymal invasion. Src inhibition by dasatinib switches NEDD9-overexpressing cells from Rac-driven mesenchymal invasion to ROCK-dependent amoeboid invasion. Overexpression/knockdown of NEDD9 and integrin β3, Src inhibitor dasatinib, phosphorylation analysis, invasion assays in vitronectin-containing matrix Journal of cell science Medium 22328516
2014 NEDD9 regulates cortactin (CTTN) acetylation in an Aurora A kinase (AURKA)/HDAC6-dependent manner: NEDD9 binds to CTTN and its deficiency increases CTTN acetylation and decreases CTTN-F-actin binding, disrupting lamellipodia and migration. A deacetylation-mimicking CTTN-9KR mutant rescues migration defects in NEDD9-depleted cells. Co-immunoprecipitation of NEDD9-CTTN, acetylation assays, AURKA/HDAC6 inhibitors, 9KR mutant rescue, xenograft metastasis models Molecular cancer research : MCR High 24574519
2014 NEDD9 directly binds to Arf6-GAP ARAP3 and Arf6-effector GGA3, facilitating Arf6 inactivation required for targeting the MMP14/TIMP2 complex to late endosomes. Without NEDD9, MMP14 trafficking is redirected from late endosomes back to the cell surface via Arf6-dependent recycling, preventing TIMP2 disengagement and reducing MMP14 activity and tumor invasion. Co-immunoprecipitation of NEDD9-ARAP3/GGA3, Arf6 activity assays, endosomal trafficking imaging, MMP14 activity assays, xenograft models with morpholino antisense Oncogene High 25241893
2013 NEDD9 depletion inactivates MMP14 via TIMP2 accumulation at the cell surface, reducing collagenolytic activity of MMP2 and MMP9 and suppressing mesenchymal invasion. Re-expression of NEDD9 restores MMP14 activity. NEDD9 is required for protease-dependent invasion at the primary site but not at the metastatic site. shRNA depletion, MMP14 activity assays, TIMP2 immunostaining, in vivo xenograft, re-expression rescue Molecular cancer research : MCR Medium 24202705
2012 NEDD9 stabilizes focal adhesions and slows focal adhesion disassembly: NEDD9-/- MEFs show increased paxillin phosphorylation at focal adhesions, increased 2D migration speed, but decreased 3D collagen migration. Loss of NEDD9 suppresses β1 integrin activation and reduces adhesion strength to fibronectin despite upregulated α5β1 expression. NEDD9-/- mouse embryo fibroblasts, focal adhesion turnover assays, 2D/3D migration assays, integrin activation assays, adhesion strength measurement PloS one Medium 22509381
2011 NEDD9 and BCAR1 signal through SRC to promote E-cadherin removal from the cell membrane and lysosomal degradation, without affecting E-cadherin transcription. Nedd9-/- mammary tumors show enhanced junctional E-cadherin. siRNA knockdown, Src inhibitors, membrane fractionation, lysosomal inhibitors, immunofluorescence, Nedd9-/- mouse mammary tumor model PloS one Medium 21765937
2000 AND-34 (a GEF) associates with HEF1/NEDD9 via its GEF domain binding to the HEF1 C-terminus; AND-34 overexpression activates Cdc42 (but not Rac, Rho, RalA, or Rap1) in B cells, enhancing PAK1 activity and inhibiting SDF-1α-induced B cell polarization. Co-immunoprecipitation, GTPase pulldown assays, PAK1 kinase assay, overexpression The Journal of biological chemistry Medium 10692442
2006 Chat-H (hematopoietic isoform of Cas/HEF1-associated signal transducer) associates with HEF1/NEDD9 (CasL) and mediates serine-threonine phosphorylation of CasL; Chat-H localization to the plasma membrane and its binding to CasL are required for T cell migration and chemokine-induced Rap1 activation. Lentiviral RNAi, co-immunoprecipitation, phosphorylation analysis, Rap1 activation assay, T cell migration assay Immunity Medium 17174122
2012 Abl and Arg tyrosine kinases mediate chemokine-induced tyrosine phosphorylation of HEF1/NEDD9; phosphorylated HEF1 is required for Rap1 GTPase activation, which mediates T cell adhesion and migration. T cells lacking Abl and Arg exhibit defective lymph node homing and impaired migration to inflammation sites. Abl/Arg knockout T cells, co-immunoprecipitation, Rap1 activation assay, in vivo homing assay, transwell migration Science signaling Medium 22810897
2012 LKB1 negatively regulates NEDD9 transcription by promoting cytosolic translocation of CRTC1 from the nucleus. Ectopic NEDD9 or CRTC1 expression partially reverses the inhibitory function of LKB1 on lung cancer metastasis, establishing a CRTC1-NEDD9 axis downstream of LKB1. RNAi silencing in de novo mouse lung tumor models, ectopic expression, subcellular fractionation of CRTC1, metastasis assays Cancer research Medium 23074285
2011 HEF1/NEDD9 is a direct transcriptional target of canonical Wnt/β-catenin signaling: ChIP assays and promoter analyses identified three functional TCF-binding sites in the HEF1 promoter responsible for Wnt-3a/β-catenin/Dvl2-driven upregulation; shRNA knockdown of β-catenin suppresses HEF1 expression. Chromatin immunoprecipitation (ChIP), promoter luciferase assays, shRNA knockdown, Wnt-3a stimulation Oncogene Medium 21317929
2010 VHL inactivation induces HEF1/NEDD9 and Aurora kinase A via stabilization of HIF-1 and HIF-2. HEF1/NEDD9 colocalizes with Aurora kinase A at the centrosome and enhances Aurora A's cilium-destabilizing effect; suppression of this pathway improves primary cilium formation and reduces motility in VHL-defective renal cancer cells. siRNA knockdown, immunofluorescence co-localization, VHL re-expression, HIF stabilization, cilia formation assay Journal of the American Society of Nephrology : JASN Medium 20864688
2010 HEF1/NEDD9 is required for VEGF-mediated head and neck cancer cell migration and invasion; VEGF promotes HEF1-dependent invadopodia formation, and HEF1 co-localizes with MT1-MMP at invadopodia. siRNA knockdown and overexpression, phosphotyrosine proteomics, invadopodia assays, co-immunolocalization Oncogene Medium 20498643
2018 Oxidation of Cys18 in the SMAD3 docking region of NEDD9 impairs SMAD3-NEDD9 protein-protein interaction in vitro (demonstrated by microscale thermophoresis). Aldosterone-induced oxidant stress in pulmonary artery endothelial cells reproduces this effect, resulting in impaired NEDD9 proteolytic degradation, increased NEDD9 complex formation with NKX2-5, and increased NKX2-5 binding to the COL3A1 promoter to upregulate collagen III. NEDD9 ablation prevents fibrotic vascular remodeling in animal PAH models. Microscale thermophoresis (in vitro protein interaction), ALDO-induced oxidant stress, Co-immunoprecipitation (NEDD9-NKX2-5), ChIP (NKX2-5 on COL3A1), atomic force microscopy, NEDD9 knockout animal model Science translational medicine High 29899023
2021 NEDD9 mediates platelet adhesion to pulmonary artery endothelial cells via a NEDD9-P-selectin interaction; under hypoxia, HIF-1α-dependent NEDD9 upregulation increases surface NEDD9. Anti-NEDD9 antibody targeting the NEDD9-P-selectin interaction inhibits platelet-endothelial adhesion in vitro and reduces pulmonary thromboembolic remodeling in vivo in NEDD9-/- mice. Network medicine/proteomics identification, microscale thermophoresis, NEDD9-/- mice, anti-NEDD9 antibody functional assay, ex vivo CTEPH patient cells American journal of respiratory and critical care medicine Medium 33523764
2016 Cas-L/NEDD9 is phosphorylated at TCR microclusters in an actin polymerization-dependent manner and is required for transport of TCR microclusters to the center of the immunological synapse; Cas-L participates in a positive feedback loop amplifying Ca2+ signaling, inside-out integrin activation, and actomyosin contraction, acting as a mechanical transducer linking TCR to actin. siRNA knockdown, super-resolution imaging of TCR microclusters, Ca2+ imaging, integrin activation assay, traction force microscopy Immunology and cell biology Medium 27359298
2009 Loss of Nedd9 in chick neural crest cells perturbs cell spreading, reduces focal complex density and actin filaments, and causes a graded reduction in migratory distance in vivo. Retinoic acid regulates Nedd9 expression in neural crest cells. siRNA knockdown and overexpression in chick neural crest, in ovo electroporation, immunofluorescence of focal complexes and actin Neuroscience Medium 19464348
2009 AhR/dioxin activation transcriptionally induces Nedd9/HEF1 via two xenobiotic response elements (XREs) in its promoter; RNAi knockdown of Nedd9 blocks dioxin-induced changes in adhesion, cytoskeleton reorganization, increased cell migration, E-cadherin repression, and JNK activation. XRE reporter assay, RNAi knockdown, AhR ligand stimulation, migration/adhesion assays Oncogene Medium 19648964
2008 NEDD9 is directly regulated by all-trans retinoic acid (atRA) through a complex retinoic acid response element (RARE) located at -475 to -445 in the NEDD9 proximal promoter; RAR and RXR are physically bound to this RARE in cells, as shown by ChIP. Promoter luciferase assays with RARE mutations, EMSA, ChIP for RAR/RXR binding Archives of biochemistry and biophysics Medium 18585997
2014 Pkd1-/-;Nedd9-/- mice show striking morphological ciliary defects with specific loss of ciliary localization of adenylyl cyclase III, and have ciliary resorption defects compatible with failure of Aurora A activation. Cystogenesis is strongly promoted in the double-mutant, indicating Nedd9 acts as a modifier of ADPKD via Aurora A-dependent ciliary maintenance. Compound Pkd1/Nedd9 genetic knockout mice, immunofluorescence of cilia, Aurora A activity analysis, cystogenesis quantification, calcium response assays Proceedings of the National Academy of Sciences of the United States of America Medium 25139996
2023 Pan-HDAC inhibitors enhance H3K9 acetylation at the NEDD9 gene promoter via inhibition of HDAC4 activity, increasing NEDD9 expression and subsequent FAK phosphorylation activation, promoting breast cancer metastasis. FAK inhibitors can reverse this metastasis. ChIP for H3K9 acetylation at NEDD9 promoter, HDAC4 inhibition, FAK phosphorylation assays, invasion assays, preclinical metastasis models Signal transduction and targeted therapy Medium 36604412
2018 NEDD9 stimulates MMP9 secretion and invadopodia formation through its substrate domain (SD) tyrosine phosphorylation and SH3 domain; mutation of all 13 YxxP motif tyrosines plus Y629 (F14NEDD9) eliminates tyrosine phosphorylation, MMP9 secretion, and invadopodia. MICAL1 silencing also reduces MMP9 secretion, suggesting NEDD9-MICAL1 cooperation. Stable expression of NEDD9 domain mutants, MMP9 secretion assays, invadopodia formation assays, MICAL1 shRNA Oncotarget Medium 29876004
2005 HTLV-I Tax physically associates with Cas-L/NEDD9, binding through the serine-rich region of Cas-L; Tax increases Cas-L expression and tyrosine phosphorylation. Exogenous Cas-L inhibits Tax-mediated NF-κB transactivation but not Tax-independent NF-κB activation. Yeast two-hybrid screen, co-immunoprecipitation, NF-κB reporter assay, co-localization Oncogene Medium 15592516

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2007 HEF1-dependent Aurora A activation induces disassembly of the primary cilium. Cell 731 17604723
2006 Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene. Cell 339 16814714
2005 The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome. Nature cell biology 204 16184168
2006 HEF1 is a necessary and specific downstream effector of FAK that promotes the migration of glioblastoma cells. Oncogene 162 16288224
1996 Structure and function of Cas-L, a 105-kD Crk-associated substrate-related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes. The Journal of experimental medicine 145 8879209
2009 NEDD9 promotes oncogenic signaling in mammary tumor development. Cancer research 119 19738060
2018 NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension. Science translational medicine 118 29899023
1997 Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells. The Journal of biological chemistry 110 9020138
2018 Estrogen receptor β promotes the vasculogenic mimicry (VM) and cell invasion via altering the lncRNA-MALAT1/miR-145-5p/NEDD9 signals in lung cancer. Oncogene 102 30250297
2007 Molecular basis for HEF1/NEDD9/Cas-L action as a multifunctional co-ordinator of invasion, apoptosis and cell cycle. Cell biochemistry and biophysics 99 17703068
2007 A new central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9. Cancer research 99 17908996
1998 Cell cycle-regulated processing of HEF1 to multiple protein forms differentially targeted to multiple subcellular compartments. Molecular and cellular biology 94 9584194
2013 HEF1 promotes epithelial mesenchymal transition and bone invasion in prostate cancer under the regulation of microRNA-145. Journal of cellular biochemistry 89 23355420
2009 Transforming growth factor beta promotes neuronal cell fate of mouse cortical and hippocampal progenitors in vitro and in vivo: identification of Nedd9 as an essential signaling component. Cerebral cortex (New York, N.Y. : 1991) 84 19587023
1997 Differential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1). The Journal of biological chemistry 84 9162067
2011 NEDD9 is a positive regulator of epithelial-mesenchymal transition and promotes invasion in aggressive breast cancer. PloS one 83 21829474
2002 Dissection of HEF1-dependent functions in motility and transcriptional regulation. Journal of cell science 80 11801728
2000 The docking protein HEF1 is an apoptotic mediator at focal adhesion sites. Molecular and cellular biology 80 10866674
2011 HEF1, a novel target of Wnt signaling, promotes colonic cell migration and cancer progression. Oncogene 79 21317929
2001 Proteolysis of the docking protein HEF1 and implications for focal adhesion dynamics. Molecular and cellular biology 73 11438665
2014 miR-145 functions as tumor suppressor and targets two oncogenes, ANGPT2 and NEDD9, in renal cell carcinoma. Journal of cancer research and clinical oncology 70 24384875
2012 NEDD9, a novel target of miR-145, increases the invasiveness of glioblastoma. Oncotarget 69 22869051
2006 HEF1-aurora A interactions: points of dialog between the cell cycle and cell attachment signaling networks. Cell cycle (Georgetown, Tex.) 68 16479169
2001 Focal adhesion kinase regulates beta1 integrin-dependent T cell migration through an HEF1 effector pathway. European journal of immunology 68 11465098
2011 NEDD9 and BCAR1 negatively regulate E-cadherin membrane localization, and promote E-cadherin degradation. PloS one 67 21765937
2009 Nedd9/Hef1/Cas-L mediates the effects of environmental pollutants on cell migration and plasticity. Oncogene 66 19648964
2000 A novel ability of Smad3 to regulate proteasomal degradation of a Cas family member HEF1. The EMBO journal 65 11118211
2023 Histone deacetylase inhibitors promote breast cancer metastasis by elevating NEDD9 expression. Signal transduction and targeted therapy 62 36604412
2012 The metastasis gene NEDD9 product acts through integrin β3 and Src to promote mesenchymal motility and inhibit amoeboid motility. Journal of cell science 62 22328516
2015 Preclinical and clinical studies of the NEDD9 scaffold protein in cancer and other diseases. Gene 61 25967390
2010 Regulation of invasive behavior by vascular endothelial growth factor is HEF1-dependent. Oncogene 59 20498643
2002 Regulation of HEF1 expression and phosphorylation by TGF-beta 1 and cell adhesion. The Journal of biological chemistry 59 12189134
2010 VHL inactivation induces HEF1 and Aurora kinase A. Journal of the American Society of Nephrology : JASN 57 20864688
1998 T cell receptor-mediated tyrosine phosphorylation of Cas-L, a 105-kDa Crk-associated substrate-related protein, and its association of Crk and C3G. The Journal of biological chemistry 57 9497377
2006 Deregulation of HEF1 impairs M-phase progression by disrupting the RhoA activation cycle. Molecular biology of the cell 54 16394104
2000 Chat, a Cas/HEF1-associated adaptor protein that integrates multiple signaling pathways. The Journal of biological chemistry 53 10692442
2016 Downregulation of NEDD9 by apigenin suppresses migration, invasion, and metastasis of colorectal cancer cells. Toxicology and applied pharmacology 52 27664007
2013 NEDD9 promotes lung cancer metastasis through epithelial-mesenchymal transition. International journal of cancer 52 24174333
2014 Role for chondroitin sulfate glycosaminoglycan in NEDD9-mediated breast cancer cell growth. Experimental cell research 50 25445787
2013 The overexpression of scaffolding protein NEDD9 promotes migration and invasion in cervical cancer via tyrosine phosphorylated FAK and SRC. PloS one 50 24058594
2013 NEDD9 depletion destabilizes Aurora A kinase and heightens the efficacy of Aurora A inhibitors: implications for treatment of metastatic solid tumors. Cancer research 46 23539442
1997 BCR/ABL-induced leukemogenesis causes phosphorylation of Hef1 and its association with Crkl. The Journal of biological chemistry 46 9405482
2019 miR-363-3p inhibits migration, invasion, and epithelial-mesenchymal transition by targeting NEDD9 and SOX4 in non-small-cell lung cancer. Journal of cellular physiology 45 31332786
2012 NEDD9 stabilizes focal adhesions, increases binding to the extra-cellular matrix and differentially effects 2D versus 3D cell migration. PloS one 44 22509381
2012 The CRTC1-NEDD9 signaling axis mediates lung cancer progression caused by LKB1 loss. Cancer research 44 23074285
1999 Dimerization of the docking/adaptor protein HEF1 via a carboxy-terminal helix-loop-helix domain. Experimental cell research 43 10502414
1999 Cytoskeleton-dependent tyrosine phosphorylation of the p130(Cas) family member HEF1 downstream of the G protein-coupled calcitonin receptor. Calcitonin induces the association of HEF1, paxillin, and focal adhesion kinase. The Journal of biological chemistry 41 10455189
2007 Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease. Human molecular genetics 39 18063669
2000 Integrin engagement, the actin cytoskeleton, and c-Src are required for the calcitonin-induced tyrosine phosphorylation of paxillin and HEF1, but not for calcitonin-induced Erk1/2 phosphorylation. The Journal of biological chemistry 39 10954702
2004 Direct interaction between Smad3, APC10, CDH1 and HEF1 in proteasomal degradation of HEF1. BMC cell biology 38 15144564
2003 The GDP exchange factor AND-34 is expressed in B cells, associates with HEF1, and activates Cdc42. Journal of immunology (Baltimore, Md. : 1950) 38 12517963
2006 The hematopoietic isoform of Cas-Hef1-associated signal transducer regulates chemokine-induced inside-out signaling and T cell trafficking. Immunity 37 17174122
2014 NEDD9 regulates actin dynamics through cortactin deacetylation in an AURKA/HDAC6-dependent manner. Molecular cancer research : MCR 36 24574519
2012 Cas and NEDD9 Contribute to Tumor Progression through Dynamic Regulation of the Cytoskeleton. Genes & cancer 36 23226575
2010 Enhanced genetic instability and dasatinib sensitivity in mammary tumor cells lacking NEDD9. Cancer research 36 20940402
2009 The retinoic acid inducible Cas-family signaling protein Nedd9 regulates neural crest cell migration by modulating adhesion and actin dynamics. Neuroscience 36 19464348
2005 The Cas family docking protein, HEF1, promotes the formation of neurite-like membrane extensions. Biochimica et biophysica acta 35 16344118
2004 Crk-associated substrate (Cas) family member, NEDD9, is regulated in human neuroblastoma cells and in the embryonic hindbrain by all-trans retinoic acid. Developmental dynamics : an official publication of the American Association of Anatomists 35 15376324
1997 Association of the Cas-like molecule HEF1 with CrkL following integrin and antigen receptor signaling in human B-cells: potential relevance to neoplastic lymphohematopoietic cells. Leukemia & lymphoma 35 9498705
2015 MicroRNA-145 suppresses cell proliferation, invasion and migration in pancreatic cancer cells by targeting NEDD9. Molecular medicine reports 34 25646678
2014 NEDD9 crucially regulates TGF-β-triggered epithelial-mesenchymal transition and cell invasion in prostate cancer cells: involvement in cancer progressiveness. The Prostate 34 24728978
2014 NEDD9/Arf6-dependent endocytic trafficking of matrix metalloproteinase 14: a novel mechanism for blocking mesenchymal cell invasion and metastasis of breast cancer. Oncogene 34 25241893
2012 Abl family kinases modulate T cell-mediated inflammation and chemokine-induced migration through the adaptor HEF1 and the GTPase Rap1. Science signaling 34 22810897
2012 Expression and clinical significance of NEDD9 in lung tissues. Medical oncology (Northwood, London, England) 33 22447485
2005 Nedd9 protein, a Cas-L homologue, is upregulated after transient global ischemia in rats: possible involvement of Nedd9 in the differentiation of neurons after ischemia. Stroke 33 16210561
2017 Baicalein inhibits pancreatic cancer cell proliferation and invasion via suppression of NEDD9 expression and its downstream Akt and ERK signaling pathways. Oncotarget 32 28915595
1999 Cas-L is required for beta 1 integrin-mediated costimulation in human Tcells. Journal of immunology (Baltimore, Md. : 1950) 32 10395641
2013 NEDD9 depletion leads to MMP14 inactivation by TIMP2 and prevents invasion and metastasis. Molecular cancer research : MCR 30 24202705
2021 NEDD9 Is a Novel and Modifiable Mediator of Platelet-Endothelial Adhesion in the Pulmonary Circulation. American journal of respiratory and critical care medicine 29 33523764
2014 Nedd9 restrains renal cystogenesis in Pkd1-/- mice. Proceedings of the National Academy of Sciences of the United States of America 29 25139996
2016 Regulation of Melanoma Progression through the TCF4/miR-125b/NEDD9 Cascade. The Journal of investigative dermatology 28 26968260
2019 SOX2 promotes hypoxia-induced breast cancer cell migration by inducing NEDD9 expression and subsequent activation of Rac1/HIF-1α signaling. Cellular & molecular biology letters 27 31462898
2019 Circulating NEDD9 is increased in pulmonary arterial hypertension: A multicenter, retrospective analysis. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 27 31952977
2018 NEDD9 promotes oncogenic signaling, a stem/mesenchymal gene signature, and aggressive ovarian cancer growth in mice. Oncogene 27 29773902
2012 Expression of NEDD9 in pancreatic ductal adenocarcinoma and its clinical significance. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 27 23247867
2005 Cell adhesion regulates Ser/Thr phosphorylation and proteasomal degradation of HEF1. Journal of cell science 27 16352661
2017 NEDD9 may regulate hepatocellular carcinoma cell metastasis by promoting epithelial-mesenchymal-transition and stemness via repressing Smad7. Oncotarget 26 27974675
2016 Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability. Immunology and cell biology 26 27359298
2021 NEDD9 promotes cancer stemness by recruiting myeloid-derived suppressor cells via CXCL8 in esophageal squamous cell carcinoma. Cancer biology & medicine 25 33710809
2010 HEF1 is a crucial mediator of the proliferative effects of prostaglandin E(2) on colon cancer cells. Cancer research 23 20068165
2019 NEDD9 Facilitates Hypoxia-Induced Gastric Cancer Cell Migration via MICAL1 Related Rac1 Activation. Frontiers in pharmacology 22 31019460
2014 High expression of NEDD9 predicts adverse outcomes of colorectal cancer patients. International journal of clinical and experimental pathology 22 24966970
2012 Role of NEDD9 in invasion and metastasis of lung adenocarcinoma. Experimental and therapeutic medicine 22 23226728
2015 Elevated expression of NEDD9 is associated with metastatic activity in gastric cancer. OncoTargets and therapy 21 25792847
2013 A requirement for Nedd9 in luminal progenitor cells prior to mammary tumorigenesis in MMTV-HER2/ErbB2 mice. Oncogene 21 23318423
2008 Association study of the NEDD9 gene with the risk of developing Alzheimer's and Parkinson's disease. Human molecular genetics 21 18579580
2006 Structure and function of cas-L and integrin-mediated signaling. Critical reviews in immunology 21 17341185
2020 Long noncoding RNA linc00467 plays an oncogenic role in hepatocellular carcinoma by regulating the miR-18a-5p/NEDD9 axis. Journal of cellular biochemistry 20 31916278
2020 Melatonin Inhibits the Progression of Oral Squamous Cell Carcinoma via Inducing miR-25-5p Expression by Directly Targeting NEDD9. Frontiers in oncology 20 33344223
2019 NEDD9 promotes invasion and migration of colorectal cancer cell line HCT116 via JNK/EMT. Oncology letters 20 31516604
2019 ZMYND10, an epigenetically regulated tumor suppressor, exerts tumor-suppressive functions via miR145-5p/NEDD9 axis in breast cancer. Clinical epigenetics 20 31801619
2018 HDAC3-mediated silencing of miR-451 decreases chemosensitivity of patients with metastatic castration-resistant prostate cancer by targeting NEDD9. Therapeutic advances in medical oncology 20 30034549
2010 The WW-HECT protein Smurf2 interacts with the Docking Protein NEDD9/HEF1 for Aurora A activation. Cell division 20 20825672
2005 HTLV-I Tax induces and associates with Crk-associated substrate lymphocyte type (Cas-L). Oncogene 20 15592516
2018 NEDD9 stimulated MMP9 secretion is required for invadopodia formation in oral squamous cell carcinoma. Oncotarget 19 29876004
2008 atRA Regulation of NEDD9, a gene involved in neurite outgrowth and cell adhesion. Archives of biochemistry and biophysics 19 18585997
1998 Differential interaction of Crkl with Cbl or C3G, Hef-1, and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc gamma RI). Journal of immunology (Baltimore, Md. : 1950) 18 9820532
2020 Radix Scutellariae Ameliorates Stress-Induced Depressive-Like Behaviors via Protecting Neurons through the TGFβ3-Smad2/3-Nedd9 Signaling Pathway. Neural plasticity 17 33273910
2019 E-cadherin and NEDD9 expression in primary colorectal cancer, metastatic lymph nodes and liver metastases. Oncology letters 17 30854064
2015 Expression of NEDD9 in hepatocellular carcinoma and its clinical significance. Oncology reports 17 25812772

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