Affinage

MYO1D

Unconventional myosin-Id · UniProt O94832

Length
1006 aa
Mass
116.2 kDa
Annotated
2026-06-10
55 papers in source corpus 20 papers cited in narrative 20 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MYO1D is an unconventional class I myosin that couples the actin cytoskeleton to membranes and acts as a conserved organizer of cellular and organismal chirality. As a motor, it has high actin-activated ATPase activity with MgADP release as the rate-limiting step, propels actin filaments rapidly, and uniquely transports unilamellar vesicles along actin filaments, distinguishing it functionally from the paralog Myo1C (PMID:37380077). In epithelial cells it drives membrane trafficking along the recycling endosome pathway in a calmodulin- and F-actin-dependent manner (PMID:11208135). A central role of MYO1D is the establishment of left-right asymmetry: in zebrafish and Xenopus it controls left-right organizer formation, cilia number and orientation, and directional fluid flow, acting through genetic interaction with the planar cell polarity component Vangl2 (PMID:29769531, PMID:29478852), and in multiciliated tracheal and ependymal epithelia it is required for rotational PCP, ciliary orientation, and asymmetric Vangl localization (PMID:26446290). In Drosophila this chirality function is mechanistically resolved as MYO1D directing clockwise circumferential F-actin flow, organizing self-rotating chiral actin rings to set dextral cell chirality [PMID:bio_10.1101_2025.05.06.648335]. At the plasma membrane MYO1D tethers unphosphorylated EGFR-family receptors (EGFR, ErbB2, ErbB4) to the actin cytoskeleton via a C-terminal β-meander motif in its tail, with overexpression elevating EGFR and promoting tumor cell motility and progression (PMID:31420606), whereas it promotes internalization of PDGFRα/β heterodimers away from the membrane to limit ERK signaling and proliferation (PMID:40404618). In Drosophila MYO1D additionally controls membrane localization of the initiator caspase Dronc to drive apoptosis-induced proliferation through a Dronc–LIMK1–F-actin–ROS–JNK axis (PMID:33238125, PMID:36469525) and sets the threshold for caspase-driven apoptosis in regenerating tissue (PMID:41345088). It also supports oligodendrocyte myelin membrane dynamics and PLP transport (PMID:27655972) and directs nuclear-to-postsynaptic mRNA transport with Nesprin1 at the Drosophila neuromuscular junction (PMID:25959729).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 2000 Medium

    Established MYO1D as an actin-based mechanoenzyme functioning in membrane trafficking, answering whether this myosin participates in intracellular transport.

    Evidence In vitro endosomal transfer assay in MDCK cells with calmodulin and actin perturbation

    PMID:11208135

    Open questions at the time
    • Did not resolve the directionality or kinetics of the motor
    • No identification of cargo adaptors on recycling endosomes
  2. 2015 High

    Linked MYO1D to planar cell polarity in ciliated epithelia, showing it organizes ciliary orientation and asymmetric PCP protein localization.

    Evidence Myo1d knockout rat with EM, immunofluorescence, and bead transport assays

    PMID:26446290

    Open questions at the time
    • Molecular mechanism connecting MYO1D motor activity to Vangl localization unresolved
    • Whether the same mechanism operates in left-right organizer cilia not addressed here
  3. 2015 Medium

    Showed MYO1D cooperates with Nesprin1 to transport mRNA along F-actin tracks to postsynaptic sites, extending its motor role to RNA localization.

    Evidence Drosophila genetic loss-of-function and co-localization imaging at the neuromuscular junction

    PMID:25959729

    Open questions at the time
    • Direct cargo-binding interaction between MYO1D and mRNP not demonstrated
    • Generality to other transcripts or tissues unknown
  4. 2018 High

    Established MYO1D as an evolutionarily conserved left-right asymmetry regulator acting through the PCP/Vangl2 pathway, resolving how it shapes symmetry-breaking flow.

    Evidence Zebrafish and Xenopus loss-of-function with cilia orientation, LRO flow, convergent extension, and vangl2 epistasis

    PMID:29478852 PMID:29769531

    Open questions at the time
    • Biochemical nature of the MYO1D-Vangl2 interaction not defined
    • How motor chirality translates to organ laterality not mechanistically resolved at this stage
  5. 2019 High

    Defined a membrane-anchoring function: MYO1D tethers unphosphorylated EGFR-family receptors to actin via a tail β-meander motif, with pro-tumorigenic consequences.

    Evidence Co-IP, domain mapping/mutagenesis, motility/viability assays, and syngeneic mouse tumor model

    PMID:31420606

    Open questions at the time
    • How receptor tethering is regulated dynamically not established
    • Whether anchoring is restored upon ligand activation unaddressed
  6. 2020 High

    Identified MYO1D as required for membrane localization of the initiator caspase Dronc, linking it to apoptosis-induced proliferation signaling.

    Evidence Drosophila mutant analysis with Dronc localization imaging, ROS, JNK reporter, and ISC mitosis quantification

    PMID:33238125

    Open questions at the time
    • Direct physical interaction between MYO1D and Dronc not shown
    • Whether mammalian caspases are similarly regulated unknown
  7. 2022 High

    Placed MYO1D as a required node in the Dronc-LIMK1-F-actin-ROS-JNK axis driving apoptosis-induced proliferation.

    Evidence Drosophila genetic epistasis with LIMK1/cofilin manipulation, ROS, JNK reporter, and F-actin staining

    PMID:36469525

    Open questions at the time
    • Mechanistic step at which MYO1D acts within the F-actin remodeling cascade not pinpointed
  8. 2022 Medium

    Showed SPAG6 drives MYO1D translocation to the membrane to upregulate EGFR-family signaling in AML, connecting MYO1D localization to oncogenic PI3K/AKT and ERK activation.

    Evidence Co-IP/MS, subcellular fractionation, overexpression/knockdown, and xenograft model

    PMID:35667090

    Open questions at the time
    • How SPAG6 triggers MYO1D translocation mechanistically unresolved
    • Direct vs. indirect SPAG6-MYO1D binding not fully dissected
  9. 2023 High

    Resolved MYO1D's motor mechanism, distinguishing it kinetically from Myo1C and establishing it as a vesicle-transporting motor.

    Evidence Transient kinetic ATPase assays, in vitro actin gliding, and vesicle transport assays with Drosophila Myo1D

    PMID:37380077

    Open questions at the time
    • Whether vertebrate MYO1D shares identical kinetics not tested
    • In vivo vesicle cargoes not identified
  10. 2024 Medium

    Showed MYO1D's distinct plasma-membrane diffusion behavior depends on both head and tail domains, potentially underlying its chirality function.

    Evidence Single-molecule imaging on Drosophila macrophage membranes with domain dissection

    PMID:38454557

    Open questions at the time
    • Causal link between diffusion behavior and chirality not demonstrated
    • Membrane lipid or protein determinants of diffusion unknown
  11. 2025 Medium

    Provided a molecular basis for chirality by showing MYO1D directs clockwise F-actin flow and self-organizes a chiral rotating actin ring, opposite to Myo1C.

    Evidence Live imaging of macrophage F-actin flow and in vitro motility reconstitution at near-physiological actin (preprint)

    PMID:bio_10.1101_2025.05.06.648335

    Open questions at the time
    • Preprint not yet peer-reviewed
    • How chiral F-actin flow is read out to orient PCP/Vangl in vivo not established
  12. 2025 High

    Refined the receptor-trafficking model by showing MYO1D promotes internalization of PDGFRα/β heterodimers to limit ERK signaling, contrasting with its EGFR-anchoring role.

    Evidence Dimer-specific interactome, MYO1D knockdown, receptor internalization imaging, ERK phosphorylation and proliferation assays

    PMID:40404618

    Open questions at the time
    • How MYO1D selectivity for heterodimers vs. homodimers is achieved unclear
    • Reconciliation of anchoring vs. internalization functions across receptor families not resolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • How MYO1D's chiral actin-organizing motor activity is mechanistically coupled to the PCP/Vangl2 machinery and to its receptor-trafficking functions in a single unifying model remains unresolved.
  • No structural model linking motor chirality to Vangl2 polarization
  • Vertebrate cargo and adaptor inventory incomplete
  • Integration of EGFR-anchoring, PDGFR-internalization, and chirality roles unestablished

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003774 cytoskeletal motor activity 3 GO:0008092 cytoskeletal protein binding 3 GO:0140313 molecular sequestering activity 1 GO:0140657 ATP-dependent activity 1
Localization
GO:0005886 plasma membrane 4 GO:0005856 cytoskeleton 3 GO:0005768 endosome 1 GO:0005815 microtubule organizing center 1
Pathway
R-HSA-1266738 Developmental Biology 3 R-HSA-162582 Signal Transduction 3 R-HSA-5357801 Programmed Cell Death 3 R-HSA-5653656 Vesicle-mediated transport 2
Partners
CALM1EGFRERBB2ERBB4PDGFRAPDGFRBSPAG6VANGL2

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2000 Myr4 (MYO1D) functions as an actin-based mechanoenzyme required for membrane trafficking along the recycling endosome pathway in MDCK epithelial cells. In vitro assays demonstrated that transfer of endocytosed markers from early endosomes to recycling endosomes depends on myr4 activity, its light chain calmodulin (CaM), and polymerized actin. In vitro endosomal transfer assay with functional perturbation of CaM and actin dynamics; identification of myr4 as CaM target protein Traffic (Copenhagen, Denmark) Medium 11208135
2015 Myo1D is required for planar cell polarity (PCP) in multi-ciliated tracheal and ependymal epithelial cells. In Myo1d knockout rats, rotational PCP of tracheal cilia is lost, cilia beat in a disordered pattern, and the asymmetric localization of PCP core protein Vangl1 is abolished. In ependymal cells, left-right positioning of basal body clusters is disrupted. Myo1d localizes to the F-actin and basal body-rich subapical cortex of ciliated tracheal cells. Knockout rat model (Myo1d KO), scanning and transmission electron microscopy, immunofluorescence localization, bead transport assays Cytoskeleton (Hoboken, N.J.) High 26446290
2015 Myo1D (Drosophila) functions with Nesprin1 (dNesp1) to direct mRNA transport from muscle nuclei to postsynaptic sites at the neuromuscular junction. Both dNesp1 and Myo1D are mutually required for their localization to immature boutons along F-actin-based 'railroad tracks.' Drosophila genetic analysis, fluorescence imaging of mRNA localization and protein co-localization, mutual requirement demonstrated by loss-of-function Neuron Medium 25959729
2018 Myosin1D (Myo1D) is an evolutionarily conserved regulator of left-right asymmetry. In zebrafish, Myo1D controls the formation and function of the left-right organizer (Kupffer's vesicle), regulates cilia orientation, and functionally interacts with the planar cell polarity pathway component VanGogh-like2 (Vangl2) to shape directional fluid flow for symmetry breaking. Zebrafish myo1d loss-of-function, genetic epistasis with vangl2, cilia orientation analysis, LRO flow measurements Nature communications High 29769531
2018 Myo1D is required for left-right axis formation in Xenopus. Morpholino-mediated myo1d knockdown disrupts organ laterality, impairs flow at the LR organizer through shorter, fewer, and non-polarized cilia, and inhibits convergent extension downstream of Wnt/PCP signaling. Genetic interaction between myo1d and vangl2 was demonstrated. Xenopus morpholino knockdown, organ placement scoring, Nodal cascade expression analysis, cilia imaging, gastrula explant convergent extension assay, ATF2 reporter for non-canonical Wnt, genetic epistasis with vangl2 Current biology : CB High 29478852
2019 MYO1D anchors unphosphorylated EGFR family members (EGFR, ErbB2, ErbB4, but not ErbB3) to the plasma membrane by binding their kinase domains via a C-terminal β-meander motif in the MYO1D tail domain. MYO1D tethers these receptors to the underlying actin cytoskeleton before ligand activation. Overexpressed MYO1D increases EGFR levels, promotes cancer cell motility and viability, and drives colorectal tumor progression in a syngeneic mouse model. Co-immunoprecipitation, co-localization studies, domain-deletion/mutagenesis of MYO1D tail, functional phenotype assays (cell motility, viability), syngeneic mouse tumor model Oncogene High 31420606
2012 Myosin-1d interacts with and is co-expressed with aspartoacylase in the nervous system. Myosin-1d localizes along axons and in the myelin compartment of the mouse sciatic nerve, and is enriched in Purkinje and granule cell layers of cerebellum, expanding to myelinated axonal tracts upon onset of myelination. Co-immunoprecipitation (interaction with aspartoacylase), immunofluorescence localization in tissue sections Brain research Low 22284616
2014 Myo1d is expressed in myelinating oligodendrocytes in the CNS, localizing to abaxonal and adaxonal (outer and inner cytoplasm-containing loop) regions of myelin. Expression increases during myelinogenesis and continues into adulthood. Immunohistochemistry with isoform-specific antibody, Western blot fractionation of myelin Journal of neuroscience research Low 24903835
2016 Myo1d knockdown in cultured oligodendrocytes causes retraction of processes, degeneration of myelin-like membrane, apoptosis, and impairs intracellular transport of myelin proteolipid protein (PLP). Myo1d localizes at the leading edge of myelin-like membrane, colocalizing with actin filaments, CNPase, and partially with PLP. siRNA knockdown, immunofluorescence colocalization, morphological analysis, PLP transport assay in cultured oligodendrocytes ASN neuro Medium 27655972
2017 Myo1d knockdown in vivo during remyelination after cuprizone-induced demyelination decreases myelin basic protein and PLP levels, increases pro-inflammatory microglia and astrocytes, decreases anti-inflammatory microglia, and increases caspase-3-positive oligodendrocytes, indicating Myo1d is required for the remyelination process and oligodendrocyte survival. In vivo siRNA injection via stereotaxy in cuprizone demyelination mouse model, immunofluorescence, cell counting Neurochemical research Medium 28986688
2022 SPAG6 interacts with MYO1D (demonstrated by immunoprecipitation and mass spectrometry). Overexpression of SPAG6 promotes translocation of MYO1D from cytosol to the cell membrane, thereby upregulating EGFR family expression and activating PI3K/AKT and ERK signaling to promote AML cell proliferation and migration. Co-immunoprecipitation, mass spectrometry, subcellular fractionation, overexpression and knockdown functional assays, xenograft mouse model Blood advances Medium 35667090
2020 In Drosophila, Myo1D is required for the membrane localization of the initiator caspase Dronc in mature enterocytes. In Myo1d mutant midguts, apoptosis-induced proliferation (AiP) signals including ROS generation, hemocyte recruitment, and JNK signaling are impaired, and intestinal stem cell mitotic activity is reduced. Drosophila myo1d mutant analysis, live imaging of Dronc membrane localization, ROS detection, JNK reporter assay, hemocyte recruitment scoring, ISC mitosis quantification Cell reports High 33238125
2022 In Drosophila, F-actin remodeling driven by LIMK1 acts downstream of the caspase Dronc and depends on Myo1D to mediate ROS production and JNK activation during apoptosis-induced proliferation (AiP). Synergistic effects of Dronc and LIMK1 co-expression on F-actin accumulation, ROS, and JNK activation are abolished in myo1d mutants, placing Myo1D as a required mediator in the Dronc-LIMK1-F-actin-ROS-JNK axis. Drosophila genetic epistasis (myo1d mutant background), LIMK1/cofilin overexpression and knockdown, ROS detection, JNK reporter assay, F-actin staining PLoS genetics High 36469525
2023 Drosophila Myo1D has distinct ATPase kinetics compared to Myo1C: a 12.5-fold higher actin-activated steady-state ATPase rate, 8-fold higher MgADP release rate, and rate-limiting step is MgADP release (vs. phosphate release for Myo1C). Myo1D propels actin filaments at higher speeds than Myo1C in in vitro gliding assays and robustly transports 50 nm unilamellar vesicles along actin filaments, while Myo1C does not support vesicle transport. Transient kinetic assays (ATPase mechanism determination), in vitro actin gliding assay, in vitro vesicle transport assay The Journal of biological chemistry High 37380077
2024 Drosophila Myo1D (but not Myo1C) exhibits a higher proportion of fast-diffusing molecules on the plasma membrane of macrophages, as measured by single-molecule imaging. This distinct membrane diffusion behavior depends on both head and tail domains of each myosin and does not exert mutual influence between paralogs. Myo1D's unique membrane dynamics may underlie its role in dextral cell chirality. Single-molecule imaging on Drosophila macrophage plasma membrane, diffusion analysis Genes to cells : devoted to molecular & cellular mechanisms Medium 38454557
2025 MYO1D preferentially binds PDGFRα/β heterodimers. Knockdown of MYO1D leads to retention of PDGFRα/β heterodimers at the plasma membrane, resulting in increased ERK1/2 phosphorylation and increased cell proliferation, indicating MYO1D normally promotes PDGFRα/β heterodimer internalization away from the plasma membrane to limit ERK signaling. PDGFR dimer-specific interactome (bimolecular fluorescence complementation + proteomics), siRNA knockdown of MYO1D, receptor internalization imaging, ERK1/2 phosphorylation assay, proliferation assay Nature communications High 40404618
2025 In Drosophila macrophages, Myo1D directs clockwise circumferential F-actin flow, while Myo1C directs counterclockwise flow; both depend on Myosin2 (Myo2). In a modified in vitro motility assay at near-physiological actin concentrations, Myo1D triggers self-organization of a clockwise-rotating chiral F-actin ring with parallel, annular barbed-end polarity, whereas Myo1C induces random F-actin flow. This provides a molecular basis for how Myo1D establishes dextral cell and organ chirality. Live imaging of F-actin flow in Drosophila macrophages, in vitro motility assay with near-physiological actin concentrations, genetic perturbation of Myo2 bioRxivpreprint Medium bio_10.1101_2025.05.06.648335
2009 Xenopus laevis Myo1D (XlMyo1d) protein is present in eggs and increases at early neurula through tadpole stages. mRNA is expressed in neural tube, pre-somitic mesoderm, somites, and cranial neural crest cells during migration; during somitogenesis, transcript localizes to a stripe overlapping the nuclear region of somites. A novel isoform-specific tail homology embedded within the TH1 domain was identified by sequence analysis. Western blot (developmental expression), whole-mount in situ hybridization (mRNA localization), sequence analysis Development, growth & differentiation Low 19382939
2025 In Drosophila, Myo1D ensures survival of apoptosis-resistant DARE cells by preventing lethal effector caspase activation, while Myo7A/Crinkled promotes effector caspase activation in the same cells. This positions Myo1D as a molecular switch controlling the threshold of caspase-driven apoptosis in a radiation-induced regenerative context. Drosophila genetic loss-of-function analysis in wing imaginal disc after ionizing radiation, caspase activity reporters, genetic interaction with Myo7A/Crinkled Nature communications Medium 41345088
2022 miR-217-5p targets MYO1D in rat podocytes, as validated by luciferase reporter assay, qRT-PCR, and Western blotting. Myo1d is predicted to be involved in actin filament organization in podocytes, and its downregulation by miR-217-5p is associated with podocyte morphological changes including shrunken cells with abnormal actin cytoskeletons. Luciferase reporter assay, qRT-PCR, Western blot (miRNA-target validation) Non-coding RNA Low 35736640

Source papers

Stage 0 corpus · 55 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2017 Global analysis of H3K27me3 as an epigenetic marker in prostate cancer progression. BMC cancer 84 28403887
2014 Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patterns. American journal of respiratory and critical care medicine 72 25006744
2000 Both calmodulin and the unconventional myosin Myr4 regulate membrane trafficking along the recycling pathway of MDCK cells. Traffic (Copenhagen, Denmark) 67 11208135
2010 Myosin 1G is an abundant class I myosin in lymphocytes whose localization at the plasma membrane depends on its ancient divergent pleckstrin homology (PH) domain (Myo1PH). The Journal of biological chemistry 60 20071333
2018 Myosin1D is an evolutionarily conserved regulator of animal left-right asymmetry. Nature communications 57 29769531
2015 Comprehensive profiling of novel microRNA-9 targets and a tumor suppressor role of microRNA-9 via targeting IGF2BP1 in hepatocellular carcinoma. Oncotarget 56 26547929
2002 Myosin-I isozymes in neonatal rodent auditory and vestibular epithelia. Journal of the Association for Research in Otolaryngology : JARO 55 12486594
2020 Coimmunoprecipitation with MYR1 Identifies Three Additional Proteins within the Toxoplasma gondii Parasitophorous Vacuole Required for Translocation of Dense Granule Effectors into Host Cells. mSphere 53 32075880
2007 High density SNP association study of a major autism linkage region on chromosome 17. Human molecular genetics 46 17376794
2018 A Conserved Role of the Unconventional Myosin 1d in Laterality Determination. Current biology : CB 39 29478852
2015 Coding and noncoding expression patterns associated with rare obesity-related disorders: Prader-Willi and Alström syndromes. Advances in genomics and genetics 30 25705109
2015 Myosin Id is required for planar cell polarity in ciliated tracheal and ependymal epithelial cells. Cytoskeleton (Hoboken, N.J.) 30 26446290
2021 Conception by fertility treatment and offspring deoxyribonucleic acid methylation. Fertility and sterility 29 33823999
2016 Selective localization of myosin-I proteins in macropinosomes and actin waves. Cytoskeleton (Hoboken, N.J.) 29 26801966
2015 Nucleus to Synapse Nesprin1 Railroad Tracks Direct Synapse Maturation through RNA Localization. Neuron 25 25959729
2022 Actin remodeling mediates ROS production and JNK activation to drive apoptosis-induced proliferation. PLoS genetics 24 36469525
2019 MYO1D binds with kinase domain of the EGFR family to anchor them to plasma membrane before their activation and contributes carcinogenesis. Oncogene 24 31420606
2012 Expression and localization of myosin-1d in the developing nervous system. Brain research 23 22284616
2012 Genome-wide DNA methylation profiling of CpG islands in hypospadias. The Journal of urology 21 22906644
2020 Transiently "Undead" Enterocytes Mediate Homeostatic Tissue Turnover in the Adult Drosophila Midgut. Cell reports 20 33238125
2007 Mapping of a novel type III variant of Knobloch syndrome (KNO3) to chromosome 17q11.2. American journal of medical genetics. Part A 15 17975799
2023 KITENIN promotes aerobic glycolysis through PKM2 induction by upregulating the c-Myc/hnRNPs axis in colorectal cancer. Cell & bioscience 14 37553596
2022 Upregulated SPAG6 promotes acute myeloid leukemia progression through MYO1D that regulates the EGFR family expression. Blood advances 14 35667090
2017 Unconventional Myosin ID is Involved in Remyelination After Cuprizone-Induced Demyelination. Neurochemical research 14 28986688
2013 Transcriptome analysis of Inbred Long Sleep and Inbred Short Sleep mice. Genes, brain, and behavior 13 23433184
2014 Unconventional myosin ID is expressed in myelinating oligodendrocytes. Journal of neuroscience research 11 24903835
2021 Novel MYO1D Missense Variant Identified Through Whole Exome Sequencing and Computational Biology Analysis Expands the Spectrum of Causal Genes of Laterality Defects. Frontiers in medicine 10 34589502
2016 Knockdown of Unconventional Myosin ID Expression Induced Morphological Change in Oligodendrocytes. ASN neuro 10 27655972
2022 Identification of metastasis-associated exoDEPs in colorectal cancer using label-free proteomics. Translational oncology 9 35303583
2019 Basic-hydrophobic sites are localized in conserved positions inside and outside of PH domains and affect localization of Dictyostelium myosin 1s. Molecular biology of the cell 9 31774725
2023 Drosophila class-I myosins that can impact left-right asymmetry have distinct ATPase kinetics. The Journal of biological chemistry 8 37380077
2020 Proteome alterations associated with the oleic acid and cis-9, trans-11 conjugated linoleic acid content in bovine skeletal muscle. Journal of proteomics 8 32335295
2025 PDGFRα/β heterodimer activation negatively affects downstream ERK1/2 signaling and cellular proliferation. Nature communications 4 40404618
2023 Quantification of hematopoietic stem and progenitor cells by targeted DNA methylation analysis. Clinical epigenetics 4 37370186
2020 Dictyostelium myosin 1F and myosin 1E inhibit actin waves in a lipid-binding-dependent and motor-independent manner. Cytoskeleton (Hoboken, N.J.) 4 32734648
2018 An Interstitial 17q11.2 de novo Deletion Involving the CDK5R1 Gene in a High-Functioning Autistic Patient. Molecular syndromology 4 30733659
2017 Expression of Unconventional Myosin VI in Oligodendrocytes. Neurochemical research 4 28828543
2015 Isobaric Tags for Relative and Absolute Quantitation-Based Proteomic Analysis of Patent and Constricted Ductus Arteriosus Tissues Confirms the Systemic Regulation of Ductus Arteriosus Closure. Journal of cardiovascular pharmacology 4 25915513
2010 Using osteoclast differentiation as a model for gene discovery in an undergraduate cell biology laboratory. Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology 4 21567867
2025 Drone pupae extract enhances Hanwoo myosatellite cell function for cultivated meat production. Journal of animal science and technology 2 39974789
2025 Conserved Phosphorylation of the Myosin1e TH1 Domain Impacts Membrane Association and Function in Yeast and Worms. Cytoskeleton (Hoboken, N.J.) 2 40205688
2025 Comparative Transcriptome Analysis Reveals the Role of the FST Gene in Goose Muscle Development. Animals : an open access journal from MDPI 2 41153936
2025 Apoptosis-resistant cells drive compensatory proliferation via cell-autonomous and non-autonomous functions of the initiator caspase Dronc. Nature communications 2 41345088
2024 Myosin1G promotes Nodal signaling to control zebrafish left-right asymmetry. Nature communications 2 39095343
2022 The Role of miR-217-5p in the Puromycin Aminonucleoside-Induced Morphological Change of Podocytes. Non-coding RNA 2 35736640
2018 Genetic Determinants of Cerebral Arterial Adaptation to Flow-loading. Current neurovascular research 2 29998805
2024 Left-right Myosin-Is, Myosin1C, and Myosin1D exhibit distinct single molecule behaviors on the plasma membrane of Drosophila macrophages. Genes to cells : devoted to molecular & cellular mechanisms 1 38454557
2024 The Initiator Caspase Dronc Drives Compensatory Proliferation of Apoptosis-Resistant Cells During Epithelial Tissue Regeneration After Ionizing Radiation. bioRxiv : the preprint server for biology 1 39282309
2023 Spatial transcriptome profiling uncovers metabolic regulation of left-right patterning. bioRxiv : the preprint server for biology 1 37131609
2023 PDGFRα/β heterodimer activation negatively affects downstream ERK1/2 signaling and cellular proliferation. bioRxiv : the preprint server for biology 1 38234806
2009 Developmental expression of Xenopus myosin 1d and identification of a myo1d tail homology that overlaps TH1. Development, growth & differentiation 1 19382939
2025 The prevalence of laterality defects in patients with congenital heart disease. Journal of human genetics 0 40467998
2025 Knockoff-Based Fine Mapping of MS-Associated SNPs in Sardinian Trios. Biochemical genetics 0 40884622
2025 Integration of exosome-related genes and differential expression analysis reveals potential biomarkers for prostate cancer. Discover oncology 0 41186840
2014 Familial Lymphoproliferative Malignancies and Tandem Duplication of NF1 Gene. Case reports in oncological medicine 0 25580325

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