Affinage

MVP

Major vault protein · UniProt Q14764

Round 2 corrected
Length
893 aa
Mass
99.3 kDa
Annotated
2026-04-29
130 papers in source corpus 11 papers cited in narrative 11 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MVP is the principal structural subunit of vault ribonucleoprotein particles, and its expression alone is sufficient to drive self-assembly of vault-like structures (PMID:15567158). Beyond its architectural role, MVP functions as a poly(ADP-ribosyl)ation substrate of the vault-associated PARP (VPARP) (PMID:10477748), mediates selective exosomal sorting of the tumor-suppressor miR-193a to regulate cell cycle progression (PMID:28211508), facilitates importin-β2-dependent nuclear import of signaling effectors such as PTPN18 (PMID:35982039), negatively regulates osteoclastogenesis by inhibiting calcineurin–NFATc1 signaling (PMID:34158848), and suppresses TBK1-dependent interferon production through lysosome-mediated TBK1 degradation (PMID:30530482). MVP also modulates MAPK signaling by binding YPEL4 and inhibiting Elk-1 activation (PMID:20555386).

Mechanistic history

Synthesis pass · year-by-year structured walk · 8 steps
  1. 1995 High

    Establishing MVP's molecular identity resolved that the lung resistance-related protein (LRP) associated with multidrug resistance was in fact the human major vault protein, placing vault biology in a clinical context.

    Evidence cDNA cloning and amino acid sequence comparison showing 87.7% identity to rat MVP, with chromosomal localization to 16p

    PMID:7585126

    Open questions at the time
    • Mechanism linking MVP to drug resistance undefined
    • No direct functional assays performed
  2. 1999 High

    Identification of VPARP as a vault-intrinsic enzyme that poly(ADP-ribosyl)ates MVP itself revealed the first post-translational regulatory circuit within vault particles.

    Evidence Yeast two-hybrid screen, in vitro poly(ADP-ribosyl)ation assay on purified vaults, pulse-chase incorporation kinetics

    PMID:10477748

    Open questions at the time
    • Functional consequence of MVP ADP-ribosylation unknown
    • Relevant cellular stimuli triggering VPARP activity not identified
  3. 2005 High

    Demonstration that heterologous expression of MVP alone produces particles with vault morphology established MVP as both necessary and sufficient for vault assembly, separating scaffold function from accessory components.

    Evidence Recombinant MVP expression in E. coli with electron microscopy confirming vault-like particle formation

    PMID:15567158

    Open questions at the time
    • Structural determinants within MVP that drive self-assembly not mapped
    • Role of vRNA and TEP1 in particle stability not resolved
  4. 2010 Medium

    The finding that MVP binds YPEL4 and inhibits Elk-1 activation provided the first evidence that MVP modulates a canonical signal transduction cascade (MAPK/ERK pathway).

    Evidence Yeast two-hybrid, GST pull-down, co-immunoprecipitation, and Elk-1 reporter assays in mammalian cells

    PMID:20555386

    Open questions at the time
    • Physiological context of MVP–YPEL4 interaction not established in vivo
    • Stoichiometry and whether interaction requires intact vaults unknown
  5. 2017 High

    Discovery that MVP selectively sorts miR-193a into exosomes linked vault biology to intercellular RNA trafficking and tumor suppression, showing that MVP loss causes miR-193a retention and G1 arrest in donor cells.

    Evidence MVP-knockout mice, RNA immunoprecipitation, exosome fractionation, tumor xenograft models

    PMID:28211508

    Open questions at the time
    • RNA sequence or structural determinants recognized by MVP for cargo selection not defined
    • Breadth of miRNA cargo beyond miR-193a not systematically profiled
  6. 2018 Medium

    Demonstration that MVP recruits TBK1 for lysosomal degradation, thereby dampening IFN production, revealed an immunoregulatory role and a mechanism coupling vault particles to innate immune signaling.

    Evidence Co-immunoprecipitation, lysosome inhibitor rescue of TBK1 levels, fluorescence imaging of TBK1 redistribution in zebrafish

    PMID:30530482

    Open questions at the time
    • Whether mammalian MVP employs the same lysosomal degradation route not confirmed
    • Adaptor or ubiquitin signals linking MVP–TBK1 to lysosomes not identified
  7. 2021 High

    Genetic loss-of-function studies in MVP-knockout mice established MVP as a negative regulator of osteoclastogenesis through inhibition of calcineurin–NFATc1 signaling, connecting vault biology to bone homeostasis.

    Evidence Total-body and monocyte-specific MVP knockout mice, micro-CT, FK506 rescue of enhanced osteoclast differentiation, AAV-mediated rescue

    PMID:34158848

    Open questions at the time
    • Direct binding interface between MVP and calcineurin not mapped
    • Whether vault particle integrity is required for calcineurin inhibition unknown
  8. 2022 Medium

    Identification of MVP as a cofactor for importin-β2-dependent nuclear import of PTPN18 expanded MVP's functional repertoire to include nucleocytoplasmic transport of signaling intermediates.

    Evidence Co-immunoprecipitation, subcellular fractionation, knockdown and overexpression studies, in vivo metastasis assays in breast cancer models

    PMID:35982039

    Open questions at the time
    • Whether MVP participates in nuclear import of other cargoes beyond PTPN18 not tested
    • Structural basis of MVP–importin-β2 cooperation not resolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • A unifying model explaining how MVP coordinates its diverse signaling roles — miRNA sorting, nuclear transport, kinase degradation, and calcineurin inhibition — and whether these functions require intact vault particles or free MVP subunits, remains unresolved.
  • No high-resolution structure of full-length human vault with bound cargo
  • Vault-dependent versus vault-independent MVP functions not delineated
  • Upstream signals controlling MVP expression or vault disassembly poorly characterized

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 2 GO:0098772 molecular function regulator activity 2 GO:0003723 RNA binding 1 GO:0005198 structural molecule activity 1
Localization
GO:0005829 cytosol 2 GO:0005634 nucleus 1 GO:0031410 cytoplasmic vesicle 1
Pathway
R-HSA-162582 Signal Transduction 2 R-HSA-168256 Immune System 1 R-HSA-5653656 Vesicle-mediated transport 1 R-HSA-9609507 Protein localization 1
Partners
CAPRIN1KPNB1PTPN18TBK1VPARPYPEL4
Complex memberships
Vault ribonucleoprotein particle

Evidence

Reading pass · 11 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1995 LRP (Lung Resistance-related Protein), a 110-kD protein associated with multidrug resistance, was identified as the human major vault protein (MVP) by cloning and amino acid sequence analysis showing 87.7% identity with rat major vault protein. The LRP/MVP gene was localized to chromosome 16. cDNA cloning, amino acid sequence analysis, chromosome localization Nature medicine High 7585126
1996 MVP (LRP) protein is broadly distributed in normal human tissues and tumors, with high expression in bronchus, digestive tract, renal proximal tubules, keratinocytes, macrophages, and adrenal cortex. Its distribution parallels that of vault organelles across species, supporting a conserved eukaryotic function. Immunohistochemistry on frozen tissue sections using monoclonal antibody LRP-56 The American journal of pathology Medium 8774142
1999 The 193-kD vault protein (VPARP) was identified as a novel poly(ADP-ribose) polymerase that interacts with MVP in a yeast two-hybrid screen. VPARP's catalytic domain can catalyze poly(ADP-ribosyl)ation, and purified vault particles retain this enzymatic activity. Crucially, MVP itself is a substrate for this vault-associated PARP activity. VPARP is incorporated into vault particles within 1.5h of biosynthesis, while MVP incorporation takes >4h. Yeast two-hybrid screen, peptide sequence analysis, in vitro poly(ADP-ribosyl)ation assay, immunoprecipitation, immunofluorescence, pulse-chase labeling The Journal of cell biology High 10477748
2004 A novel 12 bp cis-activating element (invMED1) in the MVP gene promoter (at position -148/-143) was characterized, and the nuclear factor LRP130 was identified as the binding protein. LRP130 binding intensity correlates with endogenous MVP gene expression. siRNA knockdown and transcriptional decoy experiments demonstrated that the invMED1/LRP130 couple regulates endogenous MVP gene transcriptional activity. EMSA, promoter deletion analysis, siRNA knockdown, transcriptional decoy, reporter assays in human cancer cell lines Nucleic acids research Medium 15272088
2005 Newly synthesized MVP incorporates into vault particles only after >4 hours, whereas VPARP incorporates within 1.5 hours. Expression of MVP alone in E. coli produces particles with distinct vault morphology, demonstrating MVP is sufficient for self-assembly. The C-terminal region of VPARP (lacking PARP activity) co-sediments with MVP particles, indicating the PARP domain is dispensable for interaction with MVP. Immunoprecipitation, pulse-chase labeling, heterologous expression in E. coli with electron microscopy of particles, sedimentation assay Biochemical and biophysical research communications High 15567158
2009 Severe tumor hypoxia is associated with high MVP expression in clinical cervical tumors, and MVP over-expression is linked to chemo-resistance. Tumors over-expressing MVP showed increased angiogenesis, suggesting hypoxia induces a pathway of chemo- and radiation resistance through MVP upregulation. Immunohistochemistry and tumor oxygenation measurement in 43 consecutive clinical cervical carcinoma patients Radiation oncology Low 19660100
2010 MVP interacts with YPEL4 (a Yippee domain nuclear protein) and inhibits YPEL4-mediated activation of Elk-1 in the MAPK signaling pathway. The interaction was demonstrated in mammalian cells and shown to suppress ERK signal pathway activity downstream of YPEL4. Yeast two-hybrid screen, mammalian two-hybrid assay, GST pull-down, co-immunoprecipitation, immunocytochemistry, Elk-1 reporter assay Biochemistry and cell biology Medium 20555386
2017 MVP mediates the selective sorting of miR-193a (a tumor suppressor miRNA) into exosomes. miR-193a physically interacts with MVP, and knockout of MVP causes miR-193a to accumulate in donor cells instead of being exported into exosomes, leading to G1 cell cycle arrest and inhibition of tumor progression via targeting of Caprin1 (which upregulates Ccnd2 and c-Myc). Knockout mouse models, RNA immunoprecipitation, exosome fractionation, cell cycle analysis, tumor xenograft models Nature communications High 28211508
2018 Zebrafish MVP interacts with TBK1 (a pivotal kinase in the IFN induction pathway) and recruits it from a diffuse cytoplasmic distribution to an aggregated state, then mediates lysosome-dependent degradation of TBK1, thereby suppressing IFN production and IFN-stimulated gene expression. Co-immunoprecipitation, overexpression, viral infection assays, lysosome inhibition experiments, fluorescence microscopy of TBK1 redistribution Journal of immunology Medium 30530482
2021 MVP negatively regulates osteoclastogenesis and bone resorption by inhibiting calcineurin-NFATc1 signaling. MVP-deficient mice (total body and monocyte-specific knockouts) exhibit osteoporosis-like phenotypes with enhanced osteoclast differentiation. Mechanistically, MVP deficiency enhances calcineurin-NFATc1 signaling, promotes NFATc1 activity and calcium oscillations; calcineurin inhibition with FK506 corrects the enhanced osteoclastogenesis in MVP-deficient cells. MVP re-expression in knockout cells rescues calcineurin expression. Conditional and total body MVP knockout mice, micro-CT, bone histomorphometry, in vitro osteoclast differentiation assays, calcineurin inhibitor treatment (FK506), AAV-mediated MVP overexpression, NFATc1 activity assays Theranostics High 34158848
2022 MVP and importin β2 cooperate to mediate nuclear import of the protein tyrosine phosphatase PTPN18 in breast cancer cells. Nuclear PTPN18 (but not cytoplasmic PTPN18) dephosphorylates ETS1 and promotes its degradation, and suppresses TGF-β signaling and epithelial-to-mesenchymal transition. MVP thus acts as a nuclear transport facilitator that determines the subcellular localization and consequent function of PTPN18. Co-immunoprecipitation, subcellular fractionation, ectopic expression, knockdown studies, phosphatase activity assays, metastasis assays in vivo Cell death & disease Medium 35982039

Source papers

Stage 0 corpus · 130 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
2014 A proteome-scale map of the human interactome network. Cell 977 25416956
2004 Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. Nature biotechnology 916 15592455
2020 A reference map of the human binary protein interactome. Nature 849 32296183
2009 A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Cell 843 19490893
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2012 A census of human soluble protein complexes. Cell 689 22939629
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2008 Large-scale proteomics and phosphoproteomics of urinary exosomes. Journal of the American Society of Nephrology : JASN 607 19056867
1995 The drug resistance-related protein LRP is the human major vault protein. Nature medicine 573 7585126
2003 LRP: role in vascular wall integrity and protection from atherosclerosis. Science (New York, N.Y.) 483 12690199
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2006 RAGE, LRP-1, and amyloid-beta protein in Alzheimer's disease. Acta neuropathologica 427 16865397
2005 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Genome research 409 16344560
1998 Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants. The Journal of clinical investigation 398 9449704
2017 MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression. Nature communications 390 28211508
1999 The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase. The Journal of cell biology 339 10477748
2016 Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics. Cell reports 306 27342126
2004 Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP. Development (Cambridge, England) 289 15459103
2012 A high-throughput approach for measuring temporal changes in the interactome. Nature methods 273 22863883
2022 EWSR1-induced circNEIL3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing IGF2BP3. Molecular cancer 257 35031058
1990 Proteolytic processing of the 600 kd low density lipoprotein receptor-related protein (LRP) occurs in a trans-Golgi compartment. The EMBO journal 255 2112085
2003 RNA expression of breast cancer resistance protein, lung resistance-related protein, multidrug resistance-associated proteins 1 and 2, and multidrug resistance gene 1 in breast cancer: correlation with chemotherapeutic response. Clinical cancer research : an official journal of the American Association for Cancer Research 248 12576456
2009 Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Journal of proteome research 237 19199708
2000 Role of tissue plasminogen activator receptor LRP in hippocampal long-term potentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience 235 10632583
2008 SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells. Nature cell biology 226 19098903
2017 Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification. Nature communications 221 28524877
2010 MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunology and cell biology 221 20458337
2005 The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate. The Journal of biological chemistry 210 15749709
2015 ∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis. Nature 209 26618866
2011 Toward an understanding of the protein interaction network of the human liver. Molecular systems biology 207 21988832
2013 Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy. Proceedings of the National Academy of Sciences of the United States of America 201 24067654
2007 The LDL receptor-related protein (LRP) family: an old family of proteins with new physiological functions. Annals of medicine 197 17457719
2011 Brain microvascular pericytes are immunoactive in culture: cytokine, chemokine, nitric oxide, and LRP-1 expression in response to lipopolysaccharide. Journal of neuroinflammation 182 21995440
1996 Broad distribution of the multidrug resistance-related vault lung resistance protein in normal human tissues and tumors. The American journal of pathology 182 8774142
2011 Protein interactome reveals converging molecular pathways among autism disorders. Science translational medicine 180 21653829
2019 MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1. Gastroenterology 165 30711629
2005 Beyond endocytosis: LRP function in cell migration, proliferation and vascular permeability. Journal of thrombosis and haemostasis : JTH 160 16102056
2006 Endocytic receptor LRP together with tPA and PAI-1 coordinates Mac-1-dependent macrophage migration. The EMBO journal 153 16601674
2008 Genome-scale reconstruction of the Lrp regulatory network in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America 149 19052235
2005 Substrate-trapping techniques in the identification of cellular PTP targets. Methods (San Diego, Calif.) 146 15588985
2003 Cellular growth inhibition by IGFBP-3 and TGF-beta1 requires LRP-1. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 140 14597676
2010 Macrophage LRP-1 controls plaque cellularity by regulating efferocytosis and Akt activation. Arteriosclerosis, thrombosis, and vascular biology 135 20150557
1991 Characterization of Lrp, and Escherichia coli regulatory protein that mediates a global response to leucine. The Journal of biological chemistry 129 2040596
2005 Sorting nexin 17 facilitates LRP recycling in the early endosome. The EMBO journal 128 16052210
2006 LRP in amyloid-beta production and metabolism. Annals of the New York Academy of Sciences 123 17185504
1995 A consensus sequence for binding of Lrp to DNA. Journal of bacteriology 118 7665463
2001 Crystal structure of the Lrp-like transcriptional regulator from the archaeon Pyrococcus furiosus. The EMBO journal 116 11230123
1997 Soluble low density lipoprotein receptor-related protein (LRP) circulates in human plasma. The Journal of biological chemistry 115 9295345
2002 Teratogenicity of a mutagenised Rift Valley fever virus (MVP 12) in sheep. The Onderstepoort journal of veterinary research 107 12092782
2014 An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo. The Journal of clinical investigation 101 24509082
2006 Feast/famine regulatory proteins (FFRPs): Escherichia coli Lrp, AsnC and related archaeal transcription factors. FEMS microbiology reviews 95 16438681
1996 Effects of nutrition and growth rate on Lrp levels in Escherichia coli. Journal of bacteriology 94 8955316
2006 Structural insight into gene transcriptional regulation and effector binding by the Lrp/AsnC family. Nucleic acids research 91 16528101
2002 The Sulfolobus solfataricus Lrp-like protein LysM regulates lysine biosynthesis in response to lysine availability. The Journal of biological chemistry 85 12042311
2008 Evidence for altered LRP/RAGE expression in Alzheimer lesion pathogenesis. Current Alzheimer research 84 18855584
2010 LRP-1 promotes cancer cell invasion by supporting ERK and inhibiting JNK signaling pathways. PloS one 80 20644732
1999 Characterization of the soluble form of the low density lipoprotein receptor-related protein (LRP). Experimental cell research 80 10471328
1993 Mutations affecting the ability of Escherichia coli Lrp to bind DNA, activate transcription, or respond to leucine. Journal of bacteriology 79 8432705
2002 LRP and senile plaques in Alzheimer's disease: colocalization with apolipoprotein E and with activated astrocytes. Brain research. Molecular brain research 78 12117549
1997 Do cMOAT (MRP2), other MRP homologues, and LRP play a role in MDR? Seminars in cancer biology 72 9441949
2006 The role of megalin (LRP-2/Gp330) during development. Developmental biology 71 16828734
1999 An Lrp-like protein of the hyperthermophilic archaeon Sulfolobus solfataricus which binds to its own promoter. Journal of bacteriology 71 10049378
2019 Escherichia coli Lrp Regulates One-Third of the Genome via Direct, Cooperative, and Indirect Routes. Journal of bacteriology 69 30420454
1994 Regulation of the Escherichia coli lrp gene. Journal of bacteriology 67 8144448
2000 sigma factor selectivity of Escherichia coli RNA polymerase: role for CRP, IHF and lrp transcription factors. The EMBO journal 64 10856246
2008 LRP-1 silencing prevents malignant cell invasion despite increased pericellular proteolytic activities. Molecular and cellular biology 63 18316405
2000 Involvement of low-density lipoprotein receptor-related protein (LRP) in the clearance of factor VIII in von Willebrand factor-deficient mice. Blood 63 10688827
2003 Expression of MRP1, LRP and Pgp in breast carcinoma patients treated with preoperative chemotherapy. Breast cancer research and treatment 59 14572157
2016 sRNA roles in regulating transcriptional regulators: Lrp and SoxS regulation by sRNAs. Nucleic acids research 56 27137887
2002 Evidence of functional modulation of the MEKK/JNK/cJun signaling cascade by the low density lipoprotein receptor-related protein (LRP). The Journal of biological chemistry 56 12193592
2008 Clathrin and LRP-1-independent constitutive endocytosis and recycling of uPAR. PloS one 54 19008962
2008 Leucine-responsive regulatory protein (Lrp) acts as a virulence repressor in Salmonella enterica serovar Typhimurium. Journal of bacteriology 54 19074398
2001 Association of membrane-bound amyloid precursor protein APP with the apolipoprotein E receptor LRP. Brain research. Molecular brain research 54 11245926
1989 Structure of the low-density lipoprotein receptor-related protein (LRP) promoter. Biochimica et biophysica acta 54 2597675
2005 Down-regulation of hepatic LDL receptor-related protein (LRP) in chronic renal failure. Kidney international 53 15698441
2019 Myeloid-Specific Deletion of Epsins 1 and 2 Reduces Atherosclerosis by Preventing LRP-1 Downregulation. Circulation research 52 30595089
2017 Astaxanthin acts via LRP-1 to inhibit inflammation and reverse lipopolysaccharide-induced M1/M2 polarization of microglial cells. Oncotarget 51 29050210
2003 Low density lipoprotein receptor-related protein (LRP) is required for lactoferrin-enhanced collagen gel contractile activity of human fibroblasts. The Journal of biological chemistry 50 12672816
2005 Regulation of matrix metalloproteinase (MMP) activity by the low-density lipoprotein receptor-related protein (LRP). A new function for an "old friend". Biochimie 48 15781324
1992 The lrp gene product regulates expression of lysU in Escherichia coli K-12. Journal of bacteriology 48 1569010
2016 Engineering of an Lrp family regulator SACE_Lrp improves erythromycin production in Saccharopolyspora erythraea. Metabolic engineering 46 27794466
2002 Binding of urokinase to low density lipoprotein-related receptor (LRP) regulates vascular smooth muscle cell contraction. The Journal of biological chemistry 46 12171938
2014 LRP-1: functions, signaling and implications in kidney and other diseases. International journal of molecular sciences 44 25514242
2004 LRP and PDGF signaling: a pathway to atherosclerosis. Trends in cardiovascular medicine 44 15030790
2011 Regulatory and pathogenesis roles of Mycobacterium Lrp/AsnC family transcriptional factors. Journal of cellular biochemistry 43 21608015
2001 Variation in the LRP-associated protein gene (LRPAP1) is associated with late-onset Alzheimer disease. American journal of medical genetics 42 11425005
2012 LRP-1--CD44, a new cell surface complex regulating tumor cell adhesion. Molecular and cellular biology 39 22711991
2014 Regulation of LRP-1 expression: make the point. Pathologie-biologie 38 24661974
1998 The low-density lipoprotein receptor-related protein (LRP) mediates clearance of coagulation factor Xa in vivo. Blood 38 9427709
2009 Severe hypoxia induces chemo-resistance in clinical cervical tumors through MVP over-expression. Radiation oncology (London, England) 37 19660100
2008 Competitive Lrp and Dam assembly at the pap regulatory region: implications for mechanisms of epigenetic regulation. Journal of molecular biology 37 18706913
1997 Expression of the human major vault protein LRP in acute myeloid leukemia. Experimental hematology 37 9357965
2006 The role of LRP and H-NS in transcription regulation: involvement of synergism, allostery and macromolecular crowding. Journal of molecular biology 35 17196617
1997 ERD2 proteins mediate ER retention of the HNEL signal of LRP's receptor-associated protein (RAP). Journal of cell science 35 9010785
1983 Phase II trial of mitomycin, vinblastine, and cisplatin (MVP) in non-small cell bronchogenic carcinoma. Cancer treatment reports 35 6684988
2005 Cooperative binding of the leucine-responsive regulatory protein (Lrp) to DNA. Journal of molecular biology 34 15571719
2000 LDL receptor-related protein (LRP) in Alzheimer's disease: towards a unified theory of pathogenesis. Microscopy research and technique 34 10936878
2017 The Global Regulators Lrp, LeuO, and HexA Control Secondary Metabolism in Entomopathogenic Bacteria. Frontiers in microbiology 33 28261170
2010 MVP interacts with YPEL4 and inhibits YPEL4-mediated activities of the ERK signal pathway. Biochemistry and cell biology = Biochimie et biologie cellulaire 33 20555386
2008 LRP-1: a new modulator of cytoskeleton dynamics and adhesive complex turnover in cancer cells. Cell adhesion & migration 33 19271352
2011 Exogenous or endogenous Toll-like receptor ligands: which is the MVP in tumorigenesis? Cellular and molecular life sciences : CMLS 32 22048194
2003 Modulation of the LDL receptor and LRP levels by HIV protease inhibitors. Journal of lipid research 31 12837856
2001 Modulation of Lrp action in Escherichia coli by leucine: effects on non-specific binding of Lrp to DNA. Journal of molecular biology 31 11743723
1993 Organization of Lrp-binding sites upstream of ilvIH in Salmonella typhimurium. Molecular microbiology 31 8483418
2021 Major vault protein (MVP) negatively regulates osteoclastogenesis via calcineurin-NFATc1 pathway inhibition. Theranostics 30 34158848
2020 TIMP-3 facilitates binding of target metalloproteinases to the endocytic receptor LRP-1 and promotes scavenging of MMP-1. Scientific reports 30 32694578
2011 Association of ApoE and LRP mRNA levels with dementia and AD neuropathology. Neurobiology of aging 29 21676498
2015 Knockdown of LRP/LR Induces Apoptosis in Breast and Oesophageal Cancer Cells. PloS one 28 26427016
2007 Protease nexin 1 and its receptor LRP modulate SHH signalling during cerebellar development. Development (Cambridge, England) 28 17409116
2004 New invMED1 element cis-activates human multidrug-related MDR1 and MVP genes, involving the LRP130 protein. Nucleic acids research 28 15272088
1994 The H-NS protein modulates the activation of the ilvIH operon of Escherichia coli K12 by Lrp, the leucine regulatory protein. Molecular & general genetics : MGG 28 8152423
2013 Influence of LRP-1 and apolipoprotein E on amyloid-β uptake and toxicity to cerebrovascular smooth muscle cells. Journal of Alzheimer's disease : JAD 27 22914594
2015 The Global Transcription Factor Lrp Controls Virulence Modulation in Xenorhabdus nematophila. Journal of bacteriology 26 26170407
2022 Nuclear import of PTPN18 inhibits breast cancer metastasis mediated by MVP and importin β2. Cell death & disease 25 35982039
2017 Identification of LRP-1 as an endocytosis and recycling receptor for β1-integrin in thyroid cancer cells. Oncotarget 25 29108253
2015 Knock-Down of the 37kDa/67kDa Laminin Receptor LRP/LR Impedes Telomerase Activity. PloS one 25 26545108
1997 Characterization of an lrp-like (lrpC) gene from Bacillus subtilis. Molecular & general genetics : MGG 25 9341680
1994 In vivo footprinting analysis of Lrp binding to the ilvIH promoter region of Escherichia coli. Journal of bacteriology 25 8071194
2020 LRP-1 Promotes Colon Cancer Cell Proliferation in 3D Collagen Matrices by Mediating DDR1 Endocytosis. Frontiers in cell and developmental biology 24 32582700
2011 Identification of ArgP and Lrp as transcriptional regulators of lysP, the gene encoding the specific lysine permease of Escherichia coli. Journal of bacteriology 24 21441513
2008 Polymorphisms of APOE and LRP genes in Brazilian individuals with Alzheimer disease. Alzheimer disease and associated disorders 24 18317248
2005 Characterization of MVP and VPARP assembly into vault ribonucleoprotein complexes. Biochemical and biophysical research communications 24 15567158
1999 Expression of the lung resistance protein (LRP) in primary breast cancer. Anticancer research 24 10697509
2018 Zebrafish MVP Recruits and Degrades TBK1 To Suppress IFN Production. Journal of immunology (Baltimore, Md. : 1950) 23 30530482
1999 The major vault protein (MVP), a new multidrug resistance associated protein, is frequently expressed in multiple myeloma. Leukemia & lymphoma 23 10439368
2019 Patented therapeutic approaches targeting LRP/LR for cancer treatment. Expert opinion on therapeutic patents 22 31722579