Affinage

MAFF

Transcription factor MafF · UniProt Q9ULX9

Length
164 aa
Mass
17.8 kDa
Annotated
2026-04-28
41 papers in source corpus 25 papers cited in narrative 25 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MAFF is a small nuclear bZIP transcription factor that lacks an intrinsic transactivation domain and functions as an obligatory heterodimerization partner for CNC-family (Nrf1, Nrf2, NF-E2) and Bach-family (Bach1, Bach2) proteins, which cannot bind DNA alone; MAFF homodimers act as transcriptional repressors, while heterodimer function—activation or repression—depends on the binding partner and promoter context (PMID:8361754, PMID:12490281, PMID:27058431). MAFF directly regulates diverse target gene promoters including IL11, LDLR, CLCF1, CXCL1, CSF3, SLC7A11, CDK6, AKR1C1, CCND1, ZNF711, PTGS2, OXTR, and the HBV core promoter, thereby controlling processes spanning inflammation, lipid metabolism, ferroptosis, cell cycle progression, and viral replication (PMID:34262028, PMID:33626882, PMID:38266355, PMID:33980595, PMID:30669188). MAFF expression is transcriptionally induced by proinflammatory cytokines (IL-1β, TNF) via NF-κB, by HIF under hypoxia, and by the cAMP/PKA/CREB1 pathway, while its protein stability is regulated by BAP1-mediated K48-deubiquitination and HDAC6-mediated deacetylation (PMID:16371591, PMID:33980595, PMID:38266355, PMID:39151323, PMID:39412062). Despite broad tissue expression, mafF-null mice develop normally, reflecting functional redundancy among small Maf family members (PMID:10409670).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 1993 Medium

    Identification of MafF as a nuclear bZIP protein lacking a transactivation domain established its structural distinction from large Maf oncoproteins and predicted that it would function through heterodimerization rather than autonomous transcriptional activation.

    Evidence Retroviral overexpression, immunofluorescence localization, and transformation assays in chicken embryo fibroblasts

    PMID:8361754

    Open questions at the time
    • No heterodimeric partners identified at this stage
    • Weak soft-agar colony formation not independently replicated
    • DNA-binding specificity not defined
  2. 1999 High

    Demonstration that MAFF binds the OTR promoter US-2 element and that mafF-null mice develop normally established MAFF as a sequence-specific DNA-binding factor with functional redundancy among small Maf paralogs.

    Evidence EMSA for DNA binding; gene-targeted mafF knockout mice with lacZ knock-in for expression mapping

    PMID:10409670 PMID:10527846

    Open questions at the time
    • Compound small Maf knockouts not yet tested
    • Functional consequence of OTR promoter binding in vivo not demonstrated
  3. 2002 Medium

    Biochemical demonstration that MafF forms homodimers (repressive) and heterodimers with CNC proteins (activating) on globin and antioxidant promoters defined its dual role as a molecular switch for transcriptional regulation, and identification of electrophile-responsive MAFF induction established it as a stress-responsive gene.

    Evidence Co-immunoprecipitation, promoter-reporter assays on multiple promoters; Northern blot with actinomycin D block in HepG2 cells

    PMID:11772409 PMID:12490281

    Open questions at the time
    • In vivo relevance of homodimer repression not tested
    • Whether MafF and MafG/MafK heterodimers differ in target specificity unresolved
  4. 2005 Medium

    Rapid induction of MAFF (but not MAFG/MAFK) by IL-1β and TNF at the transcriptional level revealed MAFF as a uniquely inflammatory-responsive small Maf member, linking it to NF-κB-driven gene programs.

    Evidence RT-PCR and Western blot with actinomycin D block in myometrial cells; paralog specificity confirmed

    PMID:16371591

    Open questions at the time
    • NF-κB binding to MAFF promoter not directly shown at this point
    • Downstream inflammatory targets of MAFF not yet identified
  5. 2016 High

    Consolidation across multiple labs confirmed that small Mafs including MAFF are obligatory partners for CNC (Nrf1–3, NF-E2) and Bach (Bach1, Bach2) proteins, which cannot bind DNA as monomers, establishing the general paradigm for MAFF-dependent transcriptional control.

    Evidence Integrative review of biochemical, genetic, and structural data from multiple independent laboratories

    PMID:27058431

    Open questions at the time
    • Structural basis for partner selectivity among small Mafs not resolved
    • Genome-wide binding landscape in different cell types not yet mapped
  6. 2019 Medium

    ChIP-based demonstration that MAFF directly occupies CXCL1 and CSF3 promoters and is required for their activation in myometrial cells provided the first loss-of-function evidence linking MAFF to specific inflammatory gene targets with paracrine signaling consequences.

    Evidence ChIP, siRNA knockdown, RT-qPCR, and paracrine co-culture assay in myometrial/monocytic cells

    PMID:30669188

    Open questions at the time
    • Heterodimeric partner at these promoters not identified
    • In vivo relevance in parturition not tested
  7. 2021 High

    Multiple studies revealed MAFF-BACH1 heterodimers as context-dependent activators or repressors: activating IL11 under hypoxia in breast cancer (driving STAT3 and metastasis), repressing LDLR under inflammation (reducing cholesterol uptake), and suppressing HBV transcription by competing with HNF-4α — together establishing partner- and promoter-specific functional polarity.

    Evidence ChIP-seq, ChIP-mass spectrometry, RNA-seq, CRISPR knockout, binding-site mutagenesis, in vivo metastasis and atherosclerosis models

    PMID:33626882 PMID:33980595 PMID:34262028

    Open questions at the time
    • Whether MAFF-BACH1 versus MAFF-BACH2 differ in target gene selectivity not resolved
    • Structural determinants of activating vs. repressive MAFF-BACH1 complexes unknown
  8. 2021 Medium

    circRNA-mediated regulation of MAFF expression—via cia-MAF recruiting TIP60 to the MAFF promoter and circ-ITCH sponging miR-224-5p to stabilize MAFF mRNA—established noncoding RNA layers controlling MAFF abundance with opposing functional outcomes in liver cancer.

    Evidence CRISPR knockout of circRNA, ChIP for TIP60, luciferase reporter assay, RNA pull-down, xenograft models

    PMID:31969212 PMID:34403373

    Open questions at the time
    • Whether these circRNA mechanisms operate in normal tissues unknown
    • Relative contribution of transcriptional vs. post-transcriptional MAFF regulation not quantified
  9. 2024 High

    Discovery that BAP1 deubiquitinates K48-linked ubiquitin on MAFF to stabilize it, with stabilized MAFF upregulating DUSP5 to suppress ERK signaling, revealed a post-translational axis controlling MAFF protein levels and linked MAFF to MAPK pathway regulation in colorectal cancer.

    Evidence Quantitative proteomics, DUB library screen, K48-ubiquitin-specific assays, MAFF overexpression/knockdown, xenograft models

    PMID:39151323

    Open questions at the time
    • E3 ligase responsible for K48-ubiquitination of MAFF not identified
    • Whether BAP1-MAFF axis operates in normal tissues unclear
  10. 2024 High

    Genome-wide CRISPR screens and ChIP-seq in lung adenocarcinoma identified MAFF as a direct transcriptional regulator of SLC7A11 (ferroptosis) and CDK6/CDKN2C (cell cycle), with its own expression controlled by the cAMP/PKA/CREB1 pathway, establishing MAFF as a node integrating stress signaling with cell fate decisions.

    Evidence CRISPR screens, ChIP-seq, RNA-seq, single-cell RNA-seq, xenograft models, pharmacological cAMP/PKA pathway analysis

    PMID:38266355

    Open questions at the time
    • Whether MAFF acts as activator or repressor at the SLC7A11 promoter is context-dependent and not fully resolved
    • Role of specific heterodimeric partners at these promoters not determined
  11. 2025 Medium

    Recent studies expanded the MAFF target repertoire to include CLCF1 (with BACH1, activating STAT3 in liver I/R injury), VMP1 (regulated via YTHDC1-mediated mRNA stabilization), CCND1 (activated upon ZNF655-promoted nuclear translocation), KLF5 (repressed by MAFF, derepressed by HDAC6-mediated MAFF deacetylation), AKR1C1 (ferroptosis inhibition), and PTGS2/OXTR (with NRF2 in myometrial contraction), while demonstrating MAFF suppresses YAP1 nuclear translocation to inhibit angiogenesis.

    Evidence CUT&Tag, ChIP, dual-luciferase assays, Co-IP, m6A/mRNA stability assays, HDAC6 inhibition, xenograft and disease mouse models

    PMID:39412062 PMID:40054588 PMID:40169936 PMID:41088232 PMID:41206944 PMID:41287850 PMID:41854048

    Open questions at the time
    • Mechanisms of MAFF partner selection across these diverse contexts not unified
    • HDAC6-mediated deacetylation site on MAFF not mapped
    • How ZNF655 promotes MAFF nuclear translocation mechanistically undefined

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the structural basis for MAFF's partner selectivity among CNC and Bach proteins, the identity of E3 ubiquitin ligase(s) targeting MAFF for degradation, the specific acetylation and ubiquitination sites on MAFF, and whether compound small Maf knockout reveals essential non-redundant functions in vivo.
  • No crystal structure of MAFF heterodimer
  • E3 ligase for MAFF K48-ubiquitination unidentified
  • Compound mafF/mafG/mafK knockout phenotype not fully characterized

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003677 DNA binding 12 GO:0140110 transcription regulator activity 12
Localization
GO:0005634 nucleus 3
Pathway
R-HSA-74160 Gene expression (Transcription) 12 R-HSA-162582 Signal Transduction 4 R-HSA-168256 Immune System 3 R-HSA-5357801 Programmed Cell Death 2 R-HSA-1640170 Cell Cycle 1
Partners
BACH1BAP1BATF3NRF1NRF2YTHDC1ZNF655

Evidence

Reading pass · 25 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1993 MafF is a nuclear bZIP protein that lacks a transcriptional activation domain (N-terminal acidic domain), localizes to the nucleus, and does not induce morphological transformation of chicken embryo fibroblasts but can weakly induce colony formation in soft agar when overexpressed via retroviral vector. Structural analysis, retroviral overexpression, immunofluorescence, soft agar colony assay Oncogene Medium 8361754
1999 Human MafF (hMafF) binds specifically to the US-2 DNA element in the oxytocin receptor (OTR) gene promoter, as demonstrated by electrophoretic mobility shift assay, and its protein is preferentially expressed in term myometrium, supporting a role in OTR gene upregulation at parturition. Yeast one-hybrid screen, EMSA, Northern/Western blot Biochemical and biophysical research communications Medium 10527846
1999 MafF is dispensable for normal development in mice: homozygous mafF null mutant mice are born in normal Mendelian ratios with no obvious functional deficiencies, and lacZ knock-in reveals prominent expression in gut, lung, liver, outflow tract of heart, cartilage, bone membrane, and skin but not in hematopoietic cells. Gene targeting (knockout), lacZ reporter knock-in, developmental expression analysis The Journal of biological chemistry High 10409670
2002 MafF can form homodimers and high-affinity heterodimers with CNC-bZIP family members Nrf1, Nrf2, and NF-E2; MafF homodimers do not repress transcription on gamma-globin, beta-globin, or GCS1 promoters in multiple cell lines, whereas MafF/CNC heterodimers act as weak transcriptional activators; in combination with Jun on the GCS1 promoter, MafF shows a specific regulatory role. Co-immunoprecipitation, promoter-reporter assays, overexpression in multiple cell lines Blood cells, molecules & diseases Medium 12490281
2002 mafF mRNA expression is induced to the greatest extent among the three small Maf genes by electrophile response element (EpRE) activators PDTC and PEITC (but not tBHQ) in HepG2 cells, and this induction is transcriptionally mediated, indicating mafF is a stress-responsive gene regulated via mechanisms distinct from mafG and mafK. Northern/RT-PCR, actinomycin D transcription block, multiple cell lines The Biochemical journal Medium 11772409
2005 MAFF transcript and protein levels are rapidly induced (within 30 min) by proinflammatory cytokines IL-1β and TNF in PHM1-31 myometrial cells at the transcriptional level (blocked by actinomycin D); this induction is specific to MAFF and not shared by MAFG or MAFK. RT-PCR, Western blot with MAFF-specific antiserum, actinomycin D block, time-course experiments Biology of reproduction Medium 16371591
2006 A novel protein MIP (MafF interacting protein) interacts with hMafF via its coiled-coil domain binding to the leucine zipper of hMafF; this interaction causes MIP to translocate from the cytoplasm to the nucleolus; co-expression of MIP and hMafF (but not either alone) activates transcription from a promoter containing US2 elements. In vitro pull-down, co-immunoprecipitation, subcellular localization by fluorescence microscopy, promoter-reporter assay, domain truncation Archives of biochemistry and biophysics Medium 16549056
2016 Small Maf proteins including MafF form homodimers (acting as transcriptional repressors lacking activation domain) and heterodimers with CNC proteins (p45 NF-E2, Nrf1, Nrf2, Nrf3) and Bach proteins (Bach1, Bach2); CNC and Bach proteins cannot bind DNA as monomers and require sMaf as obligatory partners; heterodimer function (activation or repression) depends on the partner. Review integrating prior biochemical, genetic, and structural data from multiple labs Gene High 27058431
2019 MAFF directly binds to the CXCL1 and CSF3 gene promoters and is required for their transcriptional activation in myometrial cells; MAFF knockdown significantly reduces CXCL1 and CSF3 transcript and protein levels, and MAFF-dependent signaling in myometrial cells can regulate cytokine and matrix metalloproteinase expression in THP-1 monocytic cells in a paracrine fashion. siRNA knockdown, chromatin immunoprecipitation (ChIP), RT-qPCR, protein measurements, paracrine co-culture assay Journal of cellular and molecular medicine Medium 30669188
2021 MAFF forms a heterodimer with BACH1 that directly targets and transcriptionally activates the IL11 gene promoter in hypoxic breast cancer cells; IL11 activation leads to downstream STAT3 signaling to promote tumor invasion and metastasis; MAFF expression is induced by HIF under hypoxia. ChIP-seq, RNA-seq, siRNA knockdown, overexpression, invasion assays, in vivo metastasis models, IL11 inhibition Nature communications High 34262028
2021 MAFF transcription is activated by a circRNA (cia-MAF) that binds to the MAFF promoter and recruits the TIP60 histone acetyltransferase complex; loss of cia-MAF reduces TIP60 complex binding at the MAFF promoter and decreases MAFF expression, impacting liver tumor-initiating cell self-renewal and metastasis. circRNA knockout (CRISPR), promoter binding assays, ChIP for TIP60 complex, overexpression, xenograft models The Journal of clinical investigation Medium 34403373
2021 In hepatocellular carcinoma, MafF is a direct target of miR-224-5p; circular RNA circ-ITCH sponges miR-224-5p to stabilize MafF expression; MafF overexpression inhibits HCC cell proliferation and induces apoptosis, acting as a tumor suppressor. Luciferase reporter assay, RNA pull-down assay, lentiviral overexpression, rescue experiments, proliferation and apoptosis assays Oncology research Medium 31969212
2021 MafF suppresses transcription from the HBV core promoter by physically binding to the promoter and competitively inhibiting HNF-4α binding to an overlapping sequence in enhancer II (EnhII); MafF expression is induced by IL-1β or TNF-α in an NF-κB-dependent manner. siRNA knockdown, CRISPR/Cas9 knockout, ChIP, overexpression with mutant binding site, HBV reporter virus, NF-κB inhibition Journal of virology High 33980595
2021 MAFF positively correlates with LDLR expression in non-inflammatory conditions but, upon LPS stimulation, forms heterodimers with BACH1 that bind the MAF recognition element (MARE) in the LDLR promoter to transcriptionally downregulate LDLR expression; BACH1 is identified as MAFF's partner under inflammatory conditions by ChIP-mass spectrometry. ChIP-seq, ChIP-mass spectrometry (ChIP-MS), siRNA knockdown, overexpression, in vivo mouse experiments, human patient correlation Circulation High 33626882
2021 miR-320a directly targets MafF mRNA (validated by RIP-Seq and luciferase reporter assay); overexpression of miR-320a inhibits MafF protein expression, increases ROS, inhibits β-cell proliferation, and induces apoptosis, causing pancreatic β-cell dysfunction. RIP-Seq, luciferase reporter assay, Western blotting, AAV8-mediated β-cell specific overexpression/inhibition, islet transplantation, hyperglycemic clamp Molecular therapy. Nucleic acids Medium 34631276
2024 BAP1, a nuclear deubiquitinating enzyme, binds to MAFF and removes K48-linked ubiquitin chains, stabilizing MAFF protein; stabilized MAFF upregulates DUSP5 expression, resulting in inhibition of ERK phosphorylation and suppression of colorectal cancer growth. Quantitative proteomics, Co-IP, DUB library screen, ubiquitination assays (K48-specific), MAFF overexpression/knockdown, in vitro and xenograft models, RNA-seq European journal of cancer High 39151323
2024 MAFF directly binds to the ZNF711 promoter and represses its transcription; MAFF also interacts with BATF3 (demonstrated by co-immunoprecipitation and co-localization), and BATF3 similarly binds the ZNF711 promoter; simultaneous knockdown of BATF3 and MAFF phenocopies single knockdowns on ZNF711 transcription and apoptosis, indicating MAFF-BATF3 heterodimer represses ZNF711. Dual luciferase assay, ChIP-PCR, Co-IP, immunofluorescence, knockdown rescue experiments Chemico-biological interactions Medium 38908812
2024 MAFF regulates ferroptosis and cell cycle progression in lung adenocarcinoma by directly controlling transcription of SLC7A11, CDK6, and CDKN2C (identified by ChIP-seq and RNA-seq); MAFF loss promotes cell cycle G1-to-S progression and reduces ferroptosis sensitivity; the cAMP/PKA/CREB1 intracellular pathway upregulates MAFF expression in response to cisplatin or ionizing radiation. CRISPR screens, ChIP-seq, RNA-seq, single-cell RNA-seq, xenograft models, pharmacological cAMP/PKA pathway analysis Drug resistance updates High 38266355
2025 MAFF and BACH1 form a heterodimer that directly binds to the CLCF1 gene promoter (identified by CUT&Tag and RNA-seq) to transcriptionally activate CLCF1, which subsequently activates STAT3 signaling to protect against hepatic ischemia-reperfusion injury by reducing apoptosis and inflammation. CUT&Tag, RNA-seq, adenovirus-mediated overexpression, mouse I/R model Cellular & molecular biology letters Medium 40169936
2025 YTHDC1 (an m6A reader) promotes nuclear export and stability of MAFF mRNA, enhancing MAFF translation; MAFF in turn transcriptionally activates VMP1, protecting hepatocytes from oxidative stress in ischemia/reperfusion injury. Knockdown/overexpression of YTHDC1 and MAFF, VMP1 rescue experiments, mouse I/R model, mechanistic mRNA stability/export assays Cellular signalling Medium 40054588
2025 ZNF655 promotes nuclear translocation of MAFF in ovarian cancer cells; nuclear MAFF directly binds the CCND1 promoter and activates its transcription, driving proliferation and stemness; MAFF knockdown phenocopies ZNF655 depletion. Co-IP, ChIP, reporter assay, knockdown/overexpression, xenograft models Cancer cell international Medium 41088232
2025 MAFF suppresses nuclear translocation of YAP1 in non-small cell lung cancer cells, reducing downstream VEGF and CTGF expression and inhibiting angiogenesis; MAFF overexpression reduces tumor growth and microvessel density in vivo. Western blot, immunofluorescence, overexpression, xenograft models, IHC for microvessel density PeerJ Medium 41287850
2025 HDAC6 deacetylates MAFF to suppress its expression; loss of MAFF derepresses KLF5 transcription (MAFF directly suppresses KLF5 promoter activity as shown by ChIP and dual luciferase reporter assay), thereby enhancing renal fibrosis and inflammation in lupus nephritis. ChIP, dual luciferase reporter assay, HDAC6 inhibition, overexpression/knockdown, in vitro and MRL/lpr mouse model Renal failure Medium 39412062
2025 NRF2 and MAFF directly target the promoters of contraction-associated protein genes PTGS2 and OXTR (confirmed by dual-luciferase reporter assay) downstream of melatonin-MT2 receptor-PKC signaling; silencing NRF2 or MAFF reduces contraction-associated protein expression and attenuates myometrial contractility. Dual-luciferase reporter assay, siRNA knockdown, collagen gel contraction assay, pharmacological receptor and kinase inhibition Journal of pineal research Medium 41854048
2025 MAFF directly binds the AKR1C1 promoter (confirmed by dual-luciferase reporter assay) and transcriptionally activates AKR1C1; the MAFF-AKR1C1 axis inhibits ferroptosis by reducing MDA accumulation and lipid ROS, thereby promoting pancreatic cancer progression. Dual-luciferase reporter assay, MAFF knockdown in cell lines, xenograft models, transcriptome sequencing QJM : monthly journal of the Association of Physicians Medium 41206944

Source papers

Stage 0 corpus · 41 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2016 Small Maf proteins (MafF, MafG, MafK): History, structure and function. Gene 198 27058431
1993 Two new members of the maf oncogene family, mafK and mafF, encode nuclear b-Zip proteins lacking putative trans-activator domain. Oncogene 162 8361754
2012 The small MAF transcription factors MAFF, MAFG and MAFK: current knowledge and perspectives. Biochimica et biophysica acta 127 22721719
2021 The HIF target MAFF promotes tumor invasion and metastasis through IL11 and STAT3 signaling. Nature communications 97 34262028
2024 MAFF confers vulnerability to cisplatin-based and ionizing radiation treatments by modulating ferroptosis and cell cycle progression in lung adenocarcinoma. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 61 38266355
1999 Characterization of the murine mafF gene. The Journal of biological chemistry 56 10409670
2021 Transcription Factor MAFF (MAF Basic Leucine Zipper Transcription Factor F) Regulates an Atherosclerosis Relevant Network Connecting Inflammation and Cholesterol Metabolism. Circulation 48 33626882
2005 Regulation of the MAFF transcription factor by proinflammatory cytokines in myometrial cells. Biology of reproduction 44 16371591
2021 Circular RNA cia-MAF drives self-renewal and metastasis of liver tumor-initiating cells via transcription factor MAFF. The Journal of clinical investigation 43 34403373
2020 MafF Is Regulated via the circ-ITCH/miR-224-5p Axis and Acts as a Tumor Suppressor in Hepatocellular Carcinoma. Oncology research 33 31969212
2002 Differential induction of mafF, mafG and mafK expression by electrophile-response-element activators. The Biochemical journal 33 11772409
1999 Molecular cloning of a human MafF homologue, which specifically binds to the oxytocin receptor gene in term myometrium. Biochemical and biophysical research communications 32 10527846
2016 Reclassification of strains MAFF 303099T and R7A into Mesorhizobiumjaponicum sp. nov. International journal of systematic and evolutionary microbiology 29 27565417
2021 miR-320a induces pancreatic β cells dysfunction in diabetes by inhibiting MafF. Molecular therapy. Nucleic acids 23 34631276
2019 Regulation of CXCL1 chemokine and CSF3 cytokine levels in myometrial cells by the MAFF transcription factor. Journal of cellular and molecular medicine 22 30669188
2020 Responsive Expression of MafF to β-Amyloid-Induced Oxidative Stress. Disease markers 20 33488846
2021 MafF Is an Antiviral Host Factor That Suppresses Transcription from Hepatitis B Virus Core Promoter. Journal of virology 19 33980595
2020 RBFOX1 Regulates the Permeability of the Blood-Tumor Barrier via the LINC00673/MAFF Pathway. Molecular therapy oncolytics 16 32322670
2002 Cloning MafF by recognition site screening with the NFE2 tandem repeat of HS2: analysis of its role in globin and GCSl genes regulation. Blood cells, molecules & diseases 16 12490281
2021 Proteome-scale profiling reveals MAFF and MAFG as two novel key transcription factors involved in palmitic acid-induced umbilical vein endothelial cell apoptosis. BMC cardiovascular disorders 14 34535081
2019 Association between genetic polymorphisms of NRF2, KEAP1, MAFF, MAFK and anti-tuberculosis drug-induced liver injury: a nested case-control study. Scientific reports 14 31586142
2018 Involvement of MAFB and MAFF in Retinoid-Mediated Suppression of Hepatocellular Carcinoma Invasion. International journal of molecular sciences 13 29757260
2024 BAP1-mediated MAFF deubiquitylation regulates tumor growth and is associated with adverse outcomes in colorectal cancer. European journal of cancer (Oxford, England : 1990) 12 39151323
2006 The novel human gene MIP functions as a co-activator of hMafF. Archives of biochemistry and biophysics 11 16549056
1997 DNA modification in carcinogen risk assessment in relation to diet: recent advances and some perspectives from a MAFF workshop. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 9 23889108
1992 Transformation of opium poppy (Papaver somniferum L.) with Agrobacterium rhizogenes MAFF 03-01724. Plant cell reports 9 24213545
2017 System modeling reveals the molecular mechanisms of HSC cell cycle alteration mediated by Maff and Egr3 under leukemia. BMC systems biology 8 28984203
2024 HDAC6 promotes inflammation in lupus nephritis mice by regulating transcription factors MAFF and KLF5 in renal fibrosis. Renal failure 7 39412062
2025 MAFF alleviates hepatic ischemia-reperfusion injury by regulating the CLCF1/STAT3 signaling pathway. Cellular & molecular biology letters 6 40169936
2024 MAFF mediates PEITC-induced enhancement of sensitivity to carboplatin in ovarian cancer cell lines via activating ZNF711 transcription in vivo and invitro. Chemico-biological interactions 4 38908812
2007 In silico restriction landmark genome scanning analysis of Xanthomonas oryzae pathovar oryzae MAFF 311018. Biochemical and biophysical research communications 4 17904519
2025 m6A reader YTHDC1 mediates MAFF nuclear export to induce VMP1 transcription and alleviate I/R-induced oxidative stress injury in hepatocytes. Cellular signalling 2 40054588
2025 MAFF drives pancreatic cancer progression through AKR1C1-mediated inhibition of ferroptosis. QJM : monthly journal of the Association of Physicians 1 41206944
2009 Establish a recombinant yeast detection system to study the effect of MIP on transactivation function of hMafF in US2-driven gene transcription. Journal of microbiological methods 1 19723544
2026 Melatonin Enhances the Myometrial Contraction Through MT2-PKC-NRF2/MAFF Signaling Pathway in Sows. Journal of pineal research 0 41854048
2025 Immunosenescence-Related Gene MAFF is Involved in Immune Regulation and Malignant Progression in Pancreatic Adenocarcinoma. Biological procedures online 0 40665213
2025 The effects of hepatocyte-specific MafF overexpression on FFA or ETOH induced hepatocyte steatosis and its underlying mechanism. Hepatology forum 0 40686592
2025 MAFF mitigates oxidative stress and pyroptosis in cardiopulmonary bypass-induced myocardium injury. Frontiers in physiology 0 40821946
2025 Targeted and personalized immunotherapy in lung adenocarcinoma: single-cell RNA sequencing of MAFF+ tumor cells and the therapeutic potential of FOS. Frontiers in immunology 0 40936936
2025 ZNF655 promotes tumor growth and chemoresistance by targeting MAFF-CCND1 axis in ovarian cancer. Cancer cell international 0 41088232
2025 MAFF inhibits angiogenesis in non-small cell lung cancer by suppressing YAP1 nuclear translocation. PeerJ 0 41287850