Affinage

BATF3

Basic leucine zipper transcriptional factor ATF-like 3 · UniProt Q9NR55

Length
127 aa
Mass
14.5 kDa
Annotated
2026-06-09
87 papers in source corpus 30 papers cited in narrative 30 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

BATF3 is a bZIP/AP-1 family transcription factor that programs lineage-specific gene expression in dendritic cells, T cells, and lymphoid malignancies by heterodimerizing with JUN family members and co-occupying AP-1–IRF composite elements (AICEs) with IRF4 or IRF8 (PMID:12087103, PMID:28659618, PMID:29588546). In dendritic cell biology, BATF3 is absolutely required for development of CD8α+/CD103+ conventional type 1 DCs, acting downstream of IRF8 specification to sustain Irf8 autoactivation at a cDC-specific superenhancer; loss of BATF3 causes decay of Irf8 expression and diversion to the CD4+ cDC lineage (PMID:19008445, PMID:26054719). These BATF3-dependent DCs orchestrate type 1 anti-pathogen and anti-tumor immunity through IL-12 production driving Th1 polarization and NK-cell IFNγ responses (PMID:25312824, PMID:29070650), CXCL9/10-mediated effector T cell trafficking into tumors (PMID:28486109), and 4-1BBL costimulation that reinvigorates CD8+ T cells during PD-1/PD-L1 blockade (PMID:38656869). BATF3 also has a T cell-intrinsic role: it is transiently induced after priming and promotes CD8+ T cell survival and the effector-to-memory transition by suppressing BIM-mediated apoptosis and remodeling chromatin accessibility (PMID:32989328, PMID:41974573). Through partnership with IRF4, BATF3 represses Foxp3 by binding regulatory regions of the locus, antagonizing iTreg induction (PMID:29147008, PMID:36090981). In B-cell and T-cell lymphomas, BATF3 functions as an oncogenic driver, partnering with JUN/JUNB and IRF4 to occupy AICEs and directly activating MYC and IL2R, with its expression maintained by superenhancers and JAK/STAT signaling (PMID:30057145, PMID:28659618, PMID:29588546, PMID:34552066).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 2002 High

    Established the biochemical basis of BATF3 action — that it substitutes for Fos in AP-1 complexes to alter DNA contacts and repress AP-1/NFAT-driven transcription.

    Evidence EMSA, protein-DNA contact mapping, and reporter assays with reconstituted p21(SNFT)/Jun/NFAT complexes

    PMID:12087103

    Open questions at the time
    • In vitro biochemistry only; no cellular lineage context
    • Genome-wide binding repertoire not defined
  2. 2008 High

    Defined BATF3 as the lineage-determining factor for CD8α+ cross-presenting dendritic cells, linking it to anti-viral and anti-tumor CD8+ T cell immunity.

    Evidence Batf3-/- knockout mice with viral challenge and tumor rejection assays

    PMID:19008445

    Open questions at the time
    • Molecular mechanism of how BATF3 specifies the lineage not yet resolved
    • Transcriptional partners undefined at this stage
  3. 2013 Medium

    Positioned BATF3 within a developmental hierarchy downstream of IRF8 and synergizing with Id2, while revealing that some CD8α+ DCs can arise BATF3-independently.

    Evidence Irf8-/- DC progenitor cell line reconstitution and multi-KO bone marrow chimeras with cross-presentation readouts

    PMID:23297132 PMID:24227775

    Open questions at the time
    • Apparent contradiction over absolute BATF3 requirement for CD8α+ versus CD103+ DCs
    • Enhancer-level mechanism not yet established
  4. 2015 High

    Resolved the developmental mechanism: BATF3 maintains Irf8 autoactivation at AICEs within a cDC-specific superenhancer after IRF8-dependent specification.

    Evidence Knockout genetics with reporter alleles, AICE chromatin analysis, and progenitor reconstitution

    PMID:26054719

    Open questions at the time
    • Direct BATF3 occupancy at the Irf8 enhancer not shown by ChIP in this study
    • Kinetics of the autoactivation switch not fully timed
  5. 2017 High

    Established BATF3-dependent DCs as the effector source of CXCL9/10 and IL-12 that control T cell trafficking, NK activation, and metastasis in tumors.

    Evidence Batf3-/- tumor models, intra-vital imaging, cell-type-specific IL-12 KO chimeras, and NK depletion

    PMID:28486109 PMID:29070650

    Open questions at the time
    • Direct transcriptional control of Cxcl9/10 and Il12 by BATF3 not mapped by ChIP
    • Relative contribution of each chemokine/cytokine in different tumors unresolved
  6. 2017 Medium

    Revealed BATF3 as a suppressor of Treg differentiation, expanding its role beyond DCs to CD4 effector fate decisions.

    Evidence BATF3 overexpression, Batf3-/- mice, ChIP at Foxp3 CNS1, and gut disease models

    PMID:29147008

    Open questions at the time
    • Cofactor requirement for Foxp3 binding not yet defined here
    • Mechanism of repression (chromatin vs direct) incomplete
  7. 2018 High

    Defined BATF3 as an oncogenic dependency in lymphomas, partnering with IRF4/JUN at superenhancers and AICEs to drive MYC and lineage programs.

    Evidence RNAi screens, ChIP, super-enhancer analysis, BET inhibition, and xenografts in ATLL/ALCL/cHL

    PMID:29588546 PMID:30057145

    Open questions at the time
    • Whether MYC induction is direct in all lymphoma subtypes not uniformly established
    • Upstream drivers of BATF3 superenhancer activity vary by tumor
  8. 2018 Medium

    Showed OX40 costimulation routes through BATF3 to close chromatin at Foxp3 in a Sirt1/7-dependent manner, integrating costimulatory signals into Treg suppression.

    Evidence OX40 stimulation, BATF3 overexpression, chromatin accessibility assays, and Sirtuin inhibition

    PMID:30021159

    Open questions at the time
    • Direct BATF3 recruitment of Sirtuins not biochemically shown
    • Single lab, in vitro chromatin readout
  9. 2019 Medium

    Demonstrated BATF3 can substitute for BATF in Th9 differentiation, partnering with IRF4 to activate Il9 downstream of TL1A signaling.

    Evidence Co-IP, ChIP at Il9 locus, luciferase reporters, and rescue of Batf-KO Th9 cells

    PMID:30617301 PMID:31776325

    Open questions at the time
    • Degree of functional redundancy with BATF in vivo unresolved
    • Single lab
  10. 2020 High

    Uncovered a T cell-intrinsic role: transiently induced BATF3 programs CD8+ T cell survival and memory by restraining BIM-mediated apoptosis.

    Evidence Conditional KO, adoptive transfer of Batf3-/- T cells, overexpression gain-of-function, and viral/Listeria infection models

    PMID:32669309 PMID:32989328

    Open questions at the time
    • Direct transcriptional regulation of Bim by BATF3 not mapped
    • Partner dependence in T cells unclear
  11. 2021 High

    Mapped a BATF3/IL2R regulatory module in ALCL, with BATF3 occupying IL2R regulatory regions to sustain cytokine responsiveness.

    Evidence H3K27ac ChIP-seq, BATF3 ChIP at IL2R regions, and KO functional validation

    PMID:34552066

    Open questions at the time
    • Feedback between IL2R-driven STAT signaling and BATF3 not fully closed
    • Single lab
  12. 2022 Medium

    Identified IRF4 as the obligate partner for BATF3-mediated Foxp3 repression and linked the complex to glycolytic reprogramming antagonistic to Treg stability.

    Evidence Irf4 KO, BATF3 overexpression, ChIP at Foxp3 regulatory region, metabolic assays, and CNS2 methylation analysis

    PMID:36090981

    Open questions at the time
    • Causal ordering of metabolic vs transcriptional effects not fully separated
    • Single lab
  13. 2023 High

    Tied BATF3 to a MYC-dependent proliferative program in TET2-disrupted CAR T cells and uncovered a conserved role suppressing p38 MAPK innate signaling.

    Evidence TET2 disruption with clonal tracking in CAR T cells; C. elegans zip-10 rescue with human BATF3 and p38/PMK-1 assays in HEK293

    PMID:36409527 PMID:36755094

    Open questions at the time
    • Direct BATF3 binding at MYC in the CAR T context not shown
    • p38 suppression mechanism (direct vs indirect) undefined
  14. 2026 Medium

    Refined BATF3's T cell-intrinsic memory program at chromatin resolution and placed it downstream of c-MYC, revealing a c-MYC→BATF3 axis promoting CD8+ T cell proliferation and survival.

    Evidence ATAC-seq with BATF3 overexpression in CTLs/CAR-T; ChIP-qPCR and luciferase mapping c-MYC binding at the BATF3 promoter

    PMID:41882260 PMID:41974573

    Open questions at the time
    • Feedforward relationship between BATF3 and MYC across contexts not unified
    • Single lab

Open questions

Synthesis pass · forward-looking unresolved questions
  • How BATF3's distinct partner choices (JUN/JUNB, IRF4, IRF8, JunD, GR) are selected in each cell type to switch between activator and repressor functions remains unresolved.
  • No structural model of context-specific BATF3 complex assembly
  • Determinants of activating versus repressive output at a given locus undefined
  • Cross-tissue comparison of BATF3 cistromes lacking

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 6 GO:0003677 DNA binding 4 GO:0098772 molecular function regulator activity 1
Localization
GO:0005634 nucleus 3
Pathway
R-HSA-1643685 Disease 5 R-HSA-168256 Immune System 5 R-HSA-74160 Gene expression (Transcription) 4 R-HSA-1266738 Developmental Biology 2
Partners
GRIRF4IRF8JUNJUNBJUNDMYCNFAT
Complex memberships
BATF3-IRF4 AICE complexBATF3-JUN/JUNB AP-1 heterodimerBATF3-JunD heterodimer

Evidence

Reading pass · 30 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2008 Batf3 deletion ablates development of CD8α+ dendritic cells in vivo, demonstrating that Batf3 is required for this DC lineage. Batf3-/- mice are defective in cross-presentation of cell-associated antigens and lack virus-specific CD8+ T cell responses, establishing Batf3-dependent DCs as essential mediators of cross-presentation. Knockout mouse (Batf3-/-), in vivo viral challenge (West Nile virus), tumor rejection assay Science High 19008445
2002 p21(SNFT)/BATF3 forms a heterodimer with Jun on AP-1 binding sites (TRE) and a trimolecular complex with Jun and NF-AT at the distal NF-AT/AP-1 composite element. Replacement of Fos by p21(SNFT) in this complex drastically alters protein-DNA contacts, and p21(SNFT)/Jun binds the NF-AT/AP-1 element cooperatively with NF-AT but with significantly reduced efficiency compared to Fos/Jun. This altered complex conformation underlies specific repression of the IL-2 promoter and AP-1-driven composite promoter elements. Biochemical DNA-binding assays, electrophoretic mobility shift assay (EMSA), protein-DNA contact analysis, transcriptional reporter assays The Journal of biological chemistry High 12087103
2015 Batf3 maintains autoactivation of Irf8 at a CD8α+ cDC-specific enhancer containing multiple AP1-IRF composite elements (AICEs) within the Irf8 superenhancer. After specification of pre-CD8 DC progenitors (which requires IRF8 but not Batf3), Batf3 becomes required for continued Irf8 autoactivation; CDPs from Batf3-/- mice fail to complete CD8α+ cDC development due to decay of Irf8 expression and divert to the CD4+ cDC lineage. Knockout mouse genetics, transcription factor reporter alleles, chromatin analysis (AICE identification), bone marrow progenitor reconstitution Nature immunology High 26054719
2013 Batf3 and Id2 have a synergistic effect on Irf8-directed CD8α+ DC development; Irf8 is upstream of Batf3 and Id2 in the developmental program; without Irf8, expression of Id2 and Batf3 alone is insufficient for CD8α+ DC development. DC progenitor cell line (DC9) derived from Irf8-/- bone marrow, retroviral transduction of transcription factors, gene expression profiling Journal of immunology Medium 24227775
2013 CD8α+ DCs can emerge independently of Batf3 (as well as Id2 and Nfil3) in short-term bone marrow reconstitution, but only Irf8 is essential for CD8α+ DC development. These Batf3-independent CD8α+ DCs retain cross-presentation capacity. In contrast, CD103+ DC development requires all four factors including Batf3. Bone marrow reconstitution with KO mice (Id2-/-, Nfil3-/-, Batf3-/-), flow cytometry, cross-presentation assay Blood Medium 23297132
2018 BATF3 and IRF4 cooperatively drive ATLL-specific gene expression; BATF3 knockdown reduces proliferation and survival of ATLL cell lines. HBZ (the HTLV-I-encoded transcription factor) binds to an ATLL-specific BATF3 super-enhancer and regulates BATF3 expression and its downstream targets including MYC. BET inhibitors collapse this HBZ-BATF3 transcriptional network. RNAi screen, ChIP, super-enhancer analysis, RNAi knockdown, BET inhibitor treatment, xenograft model Cancer cell High 30057145
2017 BATF3 interacts physically with JUN and JUNB in cHL and ALCL cell lines (established by mass spectrometry and co-immunoprecipitation). BATF3 knockdown is toxic for cHL and ALCL lines. BATF3 binds directly to the MYC promoter and MYC is a critical BATF3 target. JAK/STAT signaling (including STAT proteins directly binding the BATF3 locus by ChIP) regulates BATF3 expression. Mass spectrometry, co-immunoprecipitation, shRNA knockdown, ChIP (BATF3 binding to MYC promoter; STAT binding to BATF3 locus), JAK2 inhibitor treatment Leukemia High 28659618
2018 BATF and BATF3 bind classical AP-1 motifs and, together with IRF4, co-occupy AP-1-IRF composite elements (AICEs) in ALCL. Gene-specific inactivation of BATF or BATF3 results in growth retardation and/or cell death of ALCL cells in vitro and in vivo. The AP-1-BATF module establishes TH17/ILC3-associated gene expression in ALCL. ChIP, gene-specific CRISPR/shRNA inactivation, in vitro and in vivo (xenograft) growth assays, gene expression profiling Leukemia High 29588546
2020 BATF3 has a T cell-intrinsic role in programming CD8+ T cell survival and memory. BATF3 is expressed transiently after T cell priming. T cells lacking Batf3 show normal expansion but undergo aggravated contraction and produce diminished memory responses. BATF3 overexpression in CD8+ T cells promotes survival and memory transition. Mechanistically, BATF3 regulates T cell apoptosis and longevity via the pro-apoptotic factor BIM. Conditional KO, adoptive transfer of Batf3-/- T cells, BATF3 overexpression, viral infection models, BIM expression analysis Nature immunology High 32989328
2020 Cell-intrinsic Batf3 expression in CD8 T cells is required for establishing circulating and resident memory T cells after foodborne Listeria infection. Batf3-/- T cells undergo increased apoptosis during contraction, leading to substantially reduced memory population and impaired recall responses. Adoptive transfer of Batf3-/- CD8 T cells, foodborne Listeria monocytogenes infection model, flow cytometry for memory populations and apoptosis Journal of immunology Medium 32669309
2018 OX40 costimulation upregulates BATF3 (and BATF), which produce a closed chromatin configuration to repress Foxp3 expression in a Sirt1/7-dependent manner, thereby inhibiting iTreg induction. OX40 stimulation of naive CD4+ T cells, BATF3 overexpression, chromatin accessibility assay, Sirt1/7 inhibition Cell reports Medium 30021159
2017 BATF3 acts as a transcriptional suppressor of Treg differentiation. BATF3 binds to the CNS1 region of the Foxp3 locus and reduces Foxp3 gene expression. BATF3 is preferentially expressed in effector CD4 T cells; ectopic BATF3 expression inhibits Foxp3 induction; Batf3-deficient CD4 T cells favorably differentiate into Tregs. BATF3 overexpression, Batf3-/- mice, in vitro Treg differentiation assay, ChIP (BATF3 binding to Foxp3 CNS1), in vivo gut immune disease models Experimental & molecular medicine Medium 29147008
2022 BATF3 must partner with IRF4 to bind a regulatory region in the Foxp3 locus where they cooperatively repress FOXP3 expression and iTreg induction. BATF3-IRF4 interactions are also necessary for glycolytic reprogramming of activated T cells that is antagonistic to FOXP3 expression and stability. Irf4 KO, BATF3 overexpression, ChIP (BATF3/IRF4 binding to Foxp3 regulatory region), metabolic (glycolysis) assays, Foxp3 CNS2 methylation analysis Frontiers in immunology Medium 36090981
2019 BATF3 physically interacts with IRF4 and binds to the Il9 locus. A transactivation reporter assay showed that the BATF3-IRF4 complex induces Il9 promoter activity. BATF3 overexpression is sufficient to rescue Il9 expression and restore airway inflammation capacity in Batf KO Th9 cells, demonstrating that BATF3 can substitute for BATF during Th9 differentiation. Co-immunoprecipitation (BATF3-IRF4 interaction), ChIP (BATF3 binding to Il9 locus), luciferase reporter assay, rescue experiment in Batf KO Th9 cells Experimental & molecular medicine Medium 31776325
2019 TL1A (TNF superfamily) induces expression of BATF and BATF3 and facilitates their binding to the Il9 promoter, leading to enhanced IL-9 secretion and Th9 differentiation. Batf3-/- Th9-TL1A cells induce reduced inflammation and cytokine expression in vivo compared to WT cells. TL1A stimulation of Th9 cells, ChIP (BATF3 binding to Il9 promoter), Batf3-/- T cell transfer model, cytokine measurement Mucosal immunology Medium 30617301
2023 Disruption of TET2 enables antigen-independent CAR T cell clonal expansions that require biallelic TET2 disruption and sustained expression of BATF3 to drive a MYC-dependent proliferative program. This proliferative state is associated with reduced effector function and genomic instability, establishing TET2 as a guardian against BATF3-induced CAR T cell proliferation. TET2 gene disruption in CAR T cells, BATF3 expression analysis, tumor rejection models, clonal expansion tracking, MYC pathway analysis Nature High 36755094
2017 Batf3-dependent CD103+ DCs within the tumor microenvironment are required for effector T cell trafficking into tumors. The mechanism involves CXCL9/10 production by CD103+ DCs; absence of these DCs leads to loss of CXCL9/10 and failed T cell trafficking. Flow cytometry, intra-vital imaging, Batf3-/- tumor models, CXCL9/10 measurement, adoptive T cell transfer Cancer cell High 28486109
2014 Batf3-dependent CD103+ DCs are major producers of IL-12 during Leishmania major infection and are required for local Th1 immunity. Adoptive transfer of WT but not IL-12p40-/- Batf3-dependent DCs improved anti-L. major response in Batf3-/- mice, establishing IL-12 production as the key effector mechanism. Batf3-/- mice with L. major infection, adoptive transfer of WT vs IL-12p40-/- DCs, cytokine measurement, T cell differentiation analysis European journal of immunology High 25312824
2017 IL-12 from Batf3-dependent CD103+ DCs is critical for NK cell activation and IFNγ production, which controls tumor metastasis. Chimeric mice lacking IL-12 production specifically in Batf3-dependent DCs had metastatic burdens similar to Batf3-/- mice, establishing that DC-derived IL-12 is the critical effector mechanism for NK-cell-mediated metastasis control. Batf3-/- mice, chimeric mice with DC-specific IL-12 KO, NK cell depletion, IFNγ measurement, bone marrow-derived DC co-culture with NK cells Cancer immunology research High 29070650
2021 In ALCL, BATF3 is recruited to IL-2 receptor (IL2R) regulatory regions and regulates IL2R expression; BATF3 knockout decreases IL-2R expression. Super-enhancer analysis (H3K27ac ChIP-seq) identified BATF3 among top ALCL regulators. IL-2/IL-15 signaling activates STAT1, STAT5, and ERK1/2 downstream of IL2R, identifying a BATF3/IL-2R regulatory module. Genome-wide H3K27ac ChIP-seq, BATF3 knockout, BATF3 ChIP at IL2R regulatory regions, cytokine stimulation with pathway analysis Nature communications High 34552066
2017 In Hodgkin lymphoma, S1P/S1PR1 activates PI3-K signaling which upregulates BATF3. BATF3 in turn upregulates S1PR1, creating a feedforward oncogenic signaling loop. Knockdown of BATF3 in HL cell lines revealed that BATF3 contributed to the transcriptional programme of primary HRS cells, including upregulation of S1PR1. S1PR1/S1PR2 expression analysis, PI3-K inhibition, BATF3 shRNA knockdown, gene expression profiling, immunohistochemistry Leukemia Medium 28878352
2017 BATF3 directly promotes transcription of CXCL5 by forming a heterodimer with JunD in intestinal epithelial cells, and the resulting CXCL5-CXCR2 axis accelerates neutrophil recruitment to promote colitis-associated colon cancer. Batf3-/- mice in AOM/DSS-induced CAC model, bone marrow cross-transfusion to identify intestinal epithelial (non-cDC1) BATF3 as driver, neutrophil depletion, ChIP/reporter assay for BATF3-JunD binding to CXCL5 promoter Mucosal immunology Medium 32467604
2017 BATF3 identified as a context-specific coactivator of the glucocorticoid receptor (GR). The interaction between BATF3 and GR is modulated by the lever arm domain of GR and is influenced by the sequence of the GR binding site. BATF3 acts as a gene-specific coactivator whose potency is influenced by the GR binding site sequence. Protein-protein interaction screen for GR isoforms (GRα vs GRγ), co-immunoprecipitation, transcriptional reporter assay with BATF3 and GR variants PLoS one Medium 28708849
2018 Ectopic expression of BATF3 in mature murine B cells induces B-cell lymphomas with a germinal center B-cell-like phenotype after retroviral transduction and transplantation into Rag1-deficient recipients. In a multiple myeloma cell line, BATF3 inhibits BLIMP1 expression, suggesting an oncogenic mechanism in B-cell lymphomagenesis. Retroviral BATF3 transduction of murine B and T cells, transplantation into Rag1-/- recipients, tumor phenotyping, BLIMP1 expression analysis in myeloma cell line Oncotarget Medium 29662618
2023 The evolutionarily conserved bZIP transcription factor BATF3/ZIP-10 suppresses innate immunity by repressing the p38/PMK-1 MAPK signaling pathway. Overexpression of human BATF3 in HEK293 cells abolishes p38 activation and inhibits expression of antimicrobial peptides and cytokine genes upon Pseudomonas aeruginosa infection. C. elegans zip-10 mutant, transgenic rescue with human BATF3 cDNA, p38/PMK-1 phosphorylation assay, siRNA knockdown in HEK293 cells, antimicrobial peptide gene expression International immunology Medium 36409527
2025 BATF3 directly drives transcription of Il27 and Cxcl10 in a B cell subset. Il27 and Cxcl10 transcription is induced by synergizing TLR and CD40 signals and driven by co-induced BATF3, which directly targets these genes. B cell transcriptional profiling, ChIP (BATF3 binding to Il27 and Cxcl10 loci), TLR/CD40 co-stimulation, in vitro and in vivo functional assays Science advances Medium 41061049
2026 BATF3 overexpression in CD8+ T cells significantly enhances cell proliferation and reduces cytokine production. BATF3 specifically facilitates the transition from effector to memory phase, upregulating memory-associated genes while downregulating exhaustion markers. ATAC-seq analysis revealed that BATF3 overexpression dynamically regulates chromatin accessibility affecting cytoskeletal organization, metabolic pathways, and survival signaling. BATF3 overexpression in virus-specific CTLs and CAR-T cells, ATAC-seq for chromatin accessibility, gene expression profiling, proliferation and cytokine assays Life science alliance Medium 41974573
2026 c-MYC directly binds the BATF3 promoter approximately 1–2 kb upstream of the transcription start site (primary binding site at -1,214 to -1,203 bp) and promotes BATF3 transcription, thereby enhancing CD8+ T cell proliferation and inhibiting apoptosis. Dual-luciferase reporter assay (c-MYC binding BATF3 promoter), ChIP-qPCR (c-MYC binding site mapping), lentiviral transduction, siRNA knockdown Scientific reports Medium 41882260
2024 Within the tumor microenvironment, Batf3-lineage DCs provide 4-1BBL as a major positive co-stimulatory signal to CD8+ T cells, which mediates T cell functional reinvigoration and tumor regression during PD-1/PD-L1 blockade. Spatial transcriptomics confirmed clustering of Batf3+ DCs and CD8+ T cells in human tumors correlating with anti-PD-1 efficacy. Flow cytometry with gene-targeted mice, blocking antibody studies (4-1BBL), immunofluorescence, spatial transcriptomics on human tumor samples Cell reports High 38656869
2020 BATF3 regulates differentiation of CD8+ T lymphocytes: BATF and BATF3 deficiency promotes skin allograft long-term survival by impairing CD8+ T cell effector phenotype acquisition and cytokine production. Double KO (Batf-/-Batf3-/-) T cells fail to expand in vivo, retain a quiescent phenotype (CD62L+CD127+), and cannot produce effector cytokines to alloantigen stimulation. Batf-/- Batf3-/- double KO mice, heart and skin allograft transplant models, adoptive T cell transfer, flow cytometry for effector markers American journal of transplantation Medium 34599765

Source papers

Stage 0 corpus · 87 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2008 Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity. Science (New York, N.Y.) 1726 19008445
2017 Tumor-Residing Batf3 Dendritic Cells Are Required for Effector T Cell Trafficking and Adoptive T Cell Therapy. Cancer cell 1167 28486109
2015 Cancer Immunotherapy with Immunomodulatory Anti-CD137 and Anti-PD-1 Monoclonal Antibodies Requires BATF3-Dependent Dendritic Cells. Cancer discovery 413 26493961
2015 Batf3 maintains autoactivation of Irf8 for commitment of a CD8α(+) conventional DC clonogenic progenitor. Nature immunology 323 26054719
2012 DNGR-1 is a specific and universal marker of mouse and human Batf3-dependent dendritic cells in lymphoid and nonlymphoid tissues. Blood 214 22442345
2014 Selective and efficient generation of functional Batf3-dependent CD103+ dendritic cells from mouse bone marrow. Blood 184 25100743
2012 Expression of XCR1 Characterizes the Batf3-Dependent Lineage of Dendritic Cells Capable of Antigen Cross-Presentation. Frontiers in immunology 157 22826713
2014 Batf3-dependent CD103+ dendritic cells are major producers of IL-12 that drive local Th1 immunity against Leishmania major infection in mice. European journal of immunology 148 25312824
2014 A minor subset of Batf3-dependent antigen-presenting cells in islets of Langerhans is essential for the development of autoimmune diabetes. Immunity 131 25367577
2023 TET2 guards against unchecked BATF3-induced CAR T cell expansion. Nature 129 36755094
2018 Targeting the HTLV-I-Regulated BATF3/IRF4 Transcriptional Network in Adult T Cell Leukemia/Lymphoma. Cancer cell 113 30057145
2017 Interleukin-12 from CD103+ Batf3-Dependent Dendritic Cells Required for NK-Cell Suppression of Metastasis. Cancer immunology research 113 29070650
2020 BATF3 programs CD8+ T cell memory. Nature immunology 111 32989328
2018 OX40 Costimulation Inhibits Foxp3 Expression and Treg Induction via BATF3-Dependent and Independent Mechanisms. Cell reports 106 30021159
2014 Effective treatment of allergic airway inflammation with Helicobacter pylori immunomodulators requires BATF3-dependent dendritic cells and IL-10. Proceedings of the National Academy of Sciences of the United States of America 101 25074917
2011 Batf3-dependent CD11b(low/-) peripheral dendritic cells are GM-CSF-independent and are not required for Th cell priming after subcutaneous immunization. PloS one 98 22065991
2017 Versican-Derived Matrikines Regulate Batf3-Dendritic Cell Differentiation and Promote T Cell Infiltration in Colorectal Cancer. Journal of immunology (Baltimore, Md. : 1950) 96 28754680
2017 Intratumoral delivery of inactivated modified vaccinia virus Ankara (iMVA) induces systemic antitumor immunity via STING and Batf3-dependent dendritic cells. Science immunology 96 28763795
2013 CD8α+ DCs can be induced in the absence of transcription factors Id2, Nfil3, and Batf3. Blood 94 23297132
2011 Batf3 transcription factor-dependent DC subsets in murine CMV infection: differential impact on T-cell priming and memory inflation. European journal of immunology 80 21604258
2018 The AP-1-BATF and -BATF3 module is essential for growth, survival and TH17/ILC3 skewing of anaplastic large cell lymphoma. Leukemia 76 29588546
2018 MiR-760 suppresses human colorectal cancer growth by targeting BATF3/AP-1/cyclinD1 signaling. Journal of experimental & clinical cancer research : CR 71 29661228
2018 Batf3-Dependent Genes Control Tumor Rejection Induced by Dendritic Cells Independently of Cross-Presentation. Cancer immunology research 57 30482745
2018 Batf3+ DCs and type I IFN are critical for the efficacy of neoadjuvant cancer immunotherapy. Oncoimmunology 55 30713806
2018 Circular RNA circ_0034642 elevates BATF3 expression and promotes cell proliferation and invasion through miR-1205 in glioma. Biochemical and biophysical research communications 54 30551880
2017 An oncogenic axis of STAT-mediated BATF3 upregulation causing MYC activity in classical Hodgkin lymphoma and anaplastic large cell lymphoma. Leukemia 52 28659618
2017 The transcription factor Batf3 inhibits the differentiation of regulatory T cells in the periphery. Experimental & molecular medicine 45 29147008
2019 BATF3-dependent dendritic cells drive both effector and regulatory T-cell responses in bacterially infected tissues. PLoS pathogens 40 31188899
2021 Super-enhancer-based identification of a BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell lymphoma. Nature communications 38 34552066
2011 Antibody responses initiated by Clec9A-bearing dendritic cells in normal and Batf3(-/-) mice. Molecular immunology 38 22209163
2013 Batf3-dependent dendritic cells in the renal lymph node induce tolerance against circulating antigens. Journal of the American Society of Nephrology : JASN 37 23411785
2020 αvβ8 integrin-expression by BATF3-dependent dendritic cells facilitates early IgA responses to Rotavirus. Mucosal immunology 36 32161355
2020 Intestinal epithelium-derived BATF3 promotes colitis-associated colon cancer through facilitating CXCL5-mediated neutrophils recruitment. Mucosal immunology 36 32467604
2020 Cutting Edge: Batf3 Expression by CD8 T Cells Critically Regulates the Development of Memory Populations. Journal of immunology (Baltimore, Md. : 1950) 34 32669309
2018 A Batf3/Nlrp3/IL-18 Axis Promotes Natural Killer Cell IL-10 Production during Listeria monocytogenes Infection. Cell reports 34 29847790
2018 Batf3-Dependent Dendritic Cells Promote Optimal CD8 T Cell Responses against Respiratory Poxvirus Infection. Journal of virology 31 29875235
2016 Intestinal Batf3-dependent dendritic cells are required for optimal antiviral T-cell responses in adult and neonatal mice. Mucosal immunology 31 27600308
2013 Batf3 and Id2 have a synergistic effect on Irf8-directed classical CD8α+ dendritic cell development. Journal of immunology (Baltimore, Md. : 1950) 31 24227775
2019 A role for BATF3 in TH9 differentiation and T-cell-driven mucosal pathologies. Mucosal immunology 28 30617301
2019 Oncogenic kinase inhibition limits Batf3-dependent dendritic cell development and antitumor immunity. The Journal of experimental medicine 28 31000683
2021 Liposome induction of CD8+ T cell responses depends on CD169+ macrophages and Batf3-dependent dendritic cells and is enhanced by GM3 inclusion. Journal of controlled release : official journal of the Controlled Release Society 26 33493613
2022 Leveraging STING, Batf3 Dendritic Cells, CXCR3 Ligands, and Other Components Related to Innate Immunity to Induce A "Hot" Tumor Microenvironment That Is Responsive to Immunotherapy. Cancers 25 35626062
2021 Absence of Batf3 reveals a new dimension of cell state heterogeneity within conventional dendritic cells. iScience 25 33997687
2017 Batf3-dependent CD8α+ Dendritic Cells Aggravates Atherosclerosis via Th1 Cell Induction and Enhanced CCL5 Expression in Plaque Macrophages. EBioMedicine 25 28411140
2017 S1PR1 drives a feedforward signalling loop to regulate BATF3 and the transcriptional programme of Hodgkin lymphoma cells. Leukemia 24 28878352
2016 Batf3 selectively determines acquisition of CD8+ dendritic cell phenotype and function. Immunology and cell biology 24 27897162
2002 Correlation of transcriptional repression by p21(SNFT) with changes in DNA.NF-AT complex interactions. The Journal of biological chemistry 23 12087103
2020 BATF3 promotes malignant phenotype of colorectal cancer through the S1PR1/p-STAT3/miR-155-3p/WDR82 axis. Cancer gene therapy 20 33057139
2020 Mucosal CD8 T Cell Responses Are Shaped by Batf3-DC After Foodborne Listeria monocytogenes Infection. Frontiers in immunology 18 33042159
2016 Batf3-dependent CD103(+) dendritic cell accumulation is dispensable for mucosal and systemic antifungal host defense. Virulence 18 27191829
2024 Batf3+ DCs and the 4-1BB/4-1BBL axis are required at the effector phase in the tumor microenvironment for PD-1/PD-L1 blockade efficacy. Cell reports 17 38656869
2022 Histone Methyltransferase SETDB1 Promotes Immune Evasion in Colorectal Cancer via FOSB-Mediated Downregulation of MicroRNA-22 through BATF3/PD-L1 Pathway. Journal of immunology research 16 35497876
2019 BATF3 is sufficient for the induction of Il9 expression and can compensate for BATF during Th9 cell differentiation. Experimental & molecular medicine 16 31776325
2024 Batf3-dependent orchestration of the robust Th1 responses and fungal control during cryptococcal infection, the role of cDC1. mBio 15 38349130
2023 Preclinical Characterization of the Tau PET Tracer [18F]SNFT-1: Comparison of Tau PET Tracers. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 15 37321821
2022 Suppression of FOXP3 expression by the AP-1 family transcription factor BATF3 requires partnering with IRF4. Frontiers in immunology 15 36090981
2021 Genetically targeting the BATF family transcription factors BATF and BATF3 in the mouse abrogates effector T cell activities and enables long-term heart allograft survival. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 15 34599765
2020 Bendamustine Conditioning Skews Murine Host DCs Toward Pre-cDC1s and Reduces GvHD Independently of Batf3. Frontiers in immunology 14 32765499
2015 Batf3 deficiency proves the pivotal role of CD8α+ dendritic cells in protection induced by vaccination with attenuated Plasmodium sporozoites. Parasite immunology 13 26284735
2017 Deletion of Batf3-dependent antigen-presenting cells does not affect atherosclerotic lesion formation in mice. PloS one 11 28771609
2020 An Important Role for CD4+ T Cells in Adaptive Immunity to Toxoplasma gondii in Mice Lacking the Transcription Factor Batf3. mSphere 10 32669460
2019 Protection of Batf3-deficient mice from experimental cerebral malaria correlates with impaired cytotoxic T-cell responses and immune regulation. Immunology 10 31631339
2018 Ectopic expression of transcription factor BATF3 induces B-cell lymphomas in a murine B-cell transplantation model. Oncotarget 10 29662618
2014 Batf3-independent langerin- CX3CR1- CD8α+ splenic DCs represent a precursor for classical cross-presenting CD8α+ DCs. Journal of leukocyte biology 10 25170118
2024 BATF and BATF3 deficiency alters CD8+ effector/exhausted T cells balance in skin transplantation. Molecular medicine (Cambridge, Mass.) 8 38297190
2023 The bZIP transcription factor BATF3/ZIP-10 suppresses innate immunity by attenuating PMK-1/p38 signaling. International immunology 8 36409527
2019 Investigating the Role of BATF3 in Grass Carp (Ctenopharyngodon idella) Immune Modulation: A Fundamental Functional Analysis. International journal of molecular sciences 8 30987332
2015 Transcription factor Batf3 is important for development of CD8+ T-cell response against a phagosomal bacterium regardless of the location of antigen. Immunology and cell biology 8 26567886
2023 Essential role for Batf3-dependent dendritic cells in regulating CD8 T-cell response during SARS-CoV-2 infection. PloS one 7 38150441
2023 Donor Batf3 inhibits murine lung allograft rejection and airway fibrosis. Mucosal immunology 6 36842540
2021 Long noncoding RNA LINC01638 contributes to laryngeal squamous cell cancer progression by modulating miR-523-5p/BATF3 axis. Aging 6 33714208
2020 Resistance to Experimental Visceral Leishmaniasis in Mice Infected With Leishmania infantum Requires Batf3. Frontiers in immunology 6 33362772
2018 Immune-modulation of two BATF3 paralogues in rainbow trout Oncorhynchus mykiss. Molecular immunology 6 29747051
2017 Absence of Batf3 results in reduced liver pathology in mice infected with Schistosoma japonicum. Parasites & vectors 6 28646891
2024 Interplay of Zeb2a, Id2a and Batf3 regulates microglia and dendritic cell development in the zebrafish brain. Development (Cambridge, England) 5 38240311
2024 Concise review: The heterogenous roles of BATF3 in cancer oncogenesis and dendritic cells and T cells differentiation and function considering the importance of BATF3-dependent dendritic cells. Immunogenetics 5 38358555
2021 Usefulness of BATF3 Immunohistochemistry in Diagnosing Classical Hodgkin Lymphoma. Diagnostics (Basel, Switzerland) 3 34202976
2017 Identification and characterization of BATF3 as a context-specific coactivator of the glucocorticoid receptor. PloS one 3 28708849
2024 siRNA-mediated downregulation of BATF3 diminished proliferation and induced apoptosis through downregulating c-Myc expression in chronic myelogenous leukemia cells. Molecular biology reports 2 38217769
2024 Batf3-cDC1 control Th1 and fungicidal responses during cryptococcal meningitis: is this enough to control meningitis? mBio 2 39254303
2025 Lung-resident memory CD4+ T cells are dependent on Batf3. Journal of immunology (Baltimore, Md. : 1950) 1 40184040
2025 Ligand-receptor interactions induce and mediate regulatory functions of BATF3+ B cells. Science advances 1 41061049
2022 Knockdown of BATF3 Inhibits Gastric Cancer Cell Growth and Radioresistance via S1PR1/STAT3 Pathway. Annals of clinical and laboratory science 1 36261191
2026 c-MYC enhances transcription of the type 1 diabetes mellitus associated gene BATF3 via promoter binding. Scientific reports 0 41882260
2026 BATF3 regulates differentiation of CD8+ T lymphocytes and memory differentiation program. Life science alliance 0 41974573
2026 Loss of BATF3 impairs adipose-liver homeostasis and accelerates the transition from steatosis to fibrosis in high-fat diet-fed mice. International journal of biological sciences 0 42157937
2025 Identification and Validation of BATF3 as a Promising Biomarker Gene for Peripheral T-cell Lymphoma. Current medicinal chemistry 0 40325818

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