Affinage

LIN28B

Protein lin-28 homolog B · UniProt Q6ZN17

Length
250 aa
Mass
27.1 kDa
Annotated
2026-04-28
100 papers in source corpus 38 papers cited in narrative 38 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

LIN28B is an RNA-binding protein that functions as a master regulator of developmental timing, fetal-to-adult transitions, and oncogenesis through both let-7-dependent and let-7-independent mechanisms. In the nucleus, LIN28B sequesters primary let-7 transcripts to block Microprocessor-mediated processing, suppressing mature let-7 levels and thereby derepressing let-7 targets including MYCN, HMGA2, IGF2BP1/3, and TGF-β signaling components; its nuclear localization is regulated by KRAS/PKCβ-mediated phosphorylation at S243 and cell-cycle-dependent translocation (PMID:22118463, PMID:33107691, PMID:16971064). Independent of let-7, LIN28B directly binds and stabilizes or translationally regulates specific mRNAs (BCL11A, CLDN1, NRP-1, AKT2, EWS-FLI1, GRB2) via its cold shock domain and CCHC zinc fingers, interacts with ribosomes to suppress BCL11A translation controlling fetal hemoglobin switching, functions as an m5C reader, and partners with ZNF143 at gene promoters to activate transcription of adrenergic lineage programs (PMID:31959994, PMID:32601179, PMID:34345012, PMID:37318881). LIN28B protein stability is controlled by TRIM71-mediated polyubiquitination and proteasomal degradation counterbalanced by OTUD6B deubiquitylation at the G1/S transition, while its transcription is driven by c-Myc/N-Myc promoter binding, NF-κB occupancy at intron 1, and chromatin state regulation involving SIRT6 and macroH2A1 (PMID:24602972, PMID:36059274, PMID:19211792, PMID:27180906).

Mechanistic history

Synthesis pass · year-by-year structured walk · 23 steps
  1. 2006 Medium

    Initial characterization established that LIN28B is a cytoplasmic RNA-binding protein with cold shock and CCHC zinc finger domains whose subcellular distribution shifts during the cell cycle, with nuclear translocation linked to proliferation.

    Evidence Subcellular fractionation, immunolocalization, tet-off inducible expression, cell proliferation assay in Huh7 cells

    PMID:16971064

    Open questions at the time
    • Mechanism of cell-cycle-dependent translocation unknown
    • No RNA targets identified
    • Single cell line
  2. 2009 High

    The discovery that c-Myc and N-Myc directly bind and transactivate the LIN28B promoter established the transcriptional control axis linking MYC oncogenes to let-7 repression through LIN28B induction.

    Evidence ChIP, reporter assays, siRNA knockdown, and overexpression across human/mouse tumor models; ChIP-chip plus N-myc knockout in neural stem cells

    PMID:19211792 PMID:19495417

    Open questions at the time
    • Other transcription factors regulating LIN28B not yet mapped
    • Whether Myc regulation is direct in all tissue contexts unclear
  3. 2011 High

    A critical mechanistic distinction was drawn between LIN28A and LIN28B: LIN28B acts in the nucleus by sequestering pri-let-7 from Microprocessor, independent of TUTase, whereas LIN28A acts cytoplasmically via TUT4, resolving how two paralogs achieve the same outcome through different compartmentalized mechanisms.

    Evidence Knockdown experiments, nuclear fractionation, functional rescue assays, xenograft models

    PMID:22118463

    Open questions at the time
    • Whether LIN28B also has cytoplasmic let-7 regulatory functions was unresolved
    • Structural basis of pri-let-7 sequestration not determined
  4. 2011 Medium

    Evidence that LIN28B directly binds mRNAs (LGR5, PROM1) and enhances their expression independently of let-7 opened the concept of let-7-independent post-transcriptional functions.

    Evidence RNA pulldown, let-7 restoration controls, migration/invasion assays in colonic epithelial and cancer cells

    PMID:21625210

    Open questions at the time
    • Specificity of mRNA binding not defined at nucleotide resolution
    • Single lab, awaits independent confirmation of let-7-independence for these targets
  5. 2012 High

    In vivo transgenic modeling demonstrated that LIN28B expression in the sympathetic adrenergic lineage is sufficient to induce neuroblastoma with low let-7 and elevated MYCN, establishing LIN28B as a bona fide oncogene acting through let-7/MYCN.

    Evidence Transgenic mouse model with sympathetic lineage-targeted LIN28B, cell-based knockdown/overexpression

    PMID:23042116

    Open questions at the time
    • Let-7-independent contributions to neuroblastoma initiation not assessed
    • Cooperating genetic events not defined
  6. 2013 High

    Transcriptome-wide PAR-CLIP and domain-specific iDo-PAR-CLIP mapped LIN28B binding sites at nucleotide resolution across thousands of mRNAs and pre-let-7, revealing that binding site position reflects CSD vs CCHC zinc finger orientation and that LIN28B knockdown reduces protein synthesis from bound targets.

    Evidence PAR-CLIP, iDo-PAR-CLIP, quantitative shotgun proteomics, knockdown in cell lines

    PMID:23770886

    Open questions at the time
    • Selectivity rules for functionally consequential vs. non-functional binding sites unclear
    • Translational vs. stability effects not distinguished for most targets
  7. 2013 High

    Multiple studies converged on LIN28B's role in fetal hemoglobin regulation: LIN28B overexpression in adult erythroblasts increases HbF by downregulating BCL11A through let-7 suppression, while in vivo intestinal models demonstrated let-7-dependent tissue hypertrophy and tumorigenesis with CLIP-seq-validated direct mRNA targets.

    Evidence Bidirectional manipulation in primary human erythroblasts; intestine-targeted transgenic plus let-7c2/let-7b deletion genetic epistasis plus CLIP-seq

    PMID:23798711 PMID:24142874

    Open questions at the time
    • Whether BCL11A suppression is purely let-7-dependent or also involves direct mRNA binding by LIN28B was unresolved
    • Quantitative contribution of each LIN28B target to HbF switching unknown
  8. 2014 High

    TRIM71 was identified as the E3 ubiquitin ligase that polyubiquitinates LIN28B for proteasomal degradation via a C-terminal stretch unique to LIN28B, establishing post-translational control of LIN28B protein levels.

    Evidence Co-IP, ubiquitination assay, RING mutant and C-terminal truncation mutagenesis, proteasome inhibitor experiments

    PMID:24602972

    Open questions at the time
    • Physiological contexts regulating TRIM71-LIN28B interaction undefined
    • Whether other E3 ligases target LIN28B unknown
  9. 2014 High

    LIN28B overexpression was shown to be sufficient to initiate hepatoblastoma and hepatocellular carcinoma in mice, with IGF2BP3 identified as a critical downstream effector required for tumor growth.

    Evidence Liver-specific transgenic overexpression, conditional Lin28a/b deletion, intravenous siRNA, xenograft models with survival analysis

    PMID:25117712

    Open questions at the time
    • Direct vs. let-7-mediated mechanism of IGF2BP3 upregulation not fully resolved
    • Cell-of-origin for LIN28B-driven liver tumors not defined
  10. 2015 High

    Multiple regulatory inputs to LIN28B transcription and stability were mapped: NF-κB p65 occupancy at LIN28B intron 1, TCF7L2 binding to intron 1 forming a positive feedback loop, MYCN regulation via miR-26a-5p, macroH2A1-mediated chromatin silencing, and DIS3 ribonuclease control of LIN28B mRNA stability; the deubiquitylase OTUD6B was identified as stabilizing LIN28B at G1/S to drive MYC expression.

    Evidence ChIP at LIN28B regulatory regions, 3'UTR reporter screens, DUB screen, mRNA stability assays, in vivo tumor models

    PMID:25368430 PMID:25744721 PMID:25925570 PMID:26028027 PMID:26123663 PMID:36059274

    Open questions at the time
    • Integration of multiple transcriptional inputs into a unified regulatory logic not modeled
    • Cell-type specificity of each regulatory axis not systematically compared
  11. 2015 High

    LIN28B was established as a developmental timing regulator beyond hematopoiesis: prolonged expression delays prosensory cell cycle withdrawal and differentiation in the murine cochlea through let-7-independent mechanisms.

    Evidence Transgenic LIN28B and let-7g overexpression in mouse cochlea, cell cycle and differentiation analysis

    PMID:26139524

    Open questions at the time
    • Let-7-independent mRNA targets in cochlear development not identified
    • Whether LIN28B regulates timing in other sensory organs unknown
  12. 2015 Medium

    The cytoplasmic uridylation pathway was shown to participate in LIN28B-mediated let-7 blockade: LIN28B interacts with Dis3l2 in the cytoplasm and pre-let-7 levels influence LIN28B localization, partially bridging the nuclear sequestration and cytoplasmic degradation models.

    Evidence Co-IP of LIN28B-Dis3l2, siRNA knockdown, pre-let-7 uridylation quantification, subcellular fractionation

    PMID:26080928

    Open questions at the time
    • Relative contribution of nuclear sequestration vs. cytoplasmic uridylation/degradation for LIN28B not quantified
    • Single lab finding awaits independent confirmation
  13. 2016 High

    In vivo genetic epistasis in the hematopoietic system defined Lin28b/let-7 as the master switch controlling fetal-to-adult hematopoietic output, with HMGA2 as a downstream effector for myeloerythroid specification and Cbx2 as a later-identified PRC1 effector regulating developmental timing.

    Evidence Lin28b conditional knockout, let-7 inhibitor/mimic in vivo, Hmga2 knockdown epistasis, Cbx2 knockout

    PMID:27401346 PMID:35385744

    Open questions at the time
    • Full complement of Lin28b/let-7 effectors in HSPCs not catalogued
    • Whether Lin28b has let-7-independent functions in HSPCs not addressed
  14. 2016 High

    Lin28b was shown to control fetal T cell Treg differentiation through let-7-mediated derepression of TGF-β signaling components and to amplify the CD19/PI3K/c-Myc feedback loop for B cell positive selection, establishing Lin28b as a multi-lineage immune developmental regulator.

    Evidence Lin28b knockdown in fetal T cells with SMAD phosphorylation readout; transgenic Lin28b rescue of CD19-/- B cell development in vivo

    PMID:27793996 PMID:31562190

    Open questions at the time
    • Whether Lin28b's immune functions are entirely let-7-dependent not resolved
    • Human relevance of immune developmental timing functions not tested
  15. 2018 Medium

    LIN28B isoform-specific analysis revealed that the short isoform binds pre-let-7 without blocking maturation and antagonizes the long isoform's oncogenic let-7 suppression, introducing isoform complexity into LIN28B function.

    Evidence Isoform-specific expression, LET-7 quantification, pre-let-7 binding competition assays in colorectal cancer cells

    PMID:29330293

    Open questions at the time
    • Endogenous ratio of long:short isoform across tissues not determined
    • Single lab, not independently confirmed
  16. 2018 Medium

    Additional let-7-independent direct mRNA targets were identified: LIN28B binds AKT2 mRNA to enhance AKT2 protein and suppress apoptosis, and stabilizes NRP-1 mRNA to activate Wnt/β-catenin signaling.

    Evidence RIP-chip, RIP, mRNA stability assays, pathway inhibitor rescue in ovarian and gastric cancer cells

    PMID:29787985 PMID:30174831

    Open questions at the time
    • Whether these targets are bound in non-cancer contexts unknown
    • Functional overlap with let-7-dependent regulation of the same pathways not distinguished
  17. 2019 High

    LIN28B was found to physically interact with IGF2BP3 and jointly stabilize thousands of mRNAs in fetal B-cell progenitors, identifying a cooperative RNA-binding protein partnership that reactivates fetal-like gene expression programs.

    Evidence Proteomics, in situ co-localization, co-expression in adult HSPCs, RNA binding site mapping

    PMID:31221665

    Open questions at the time
    • Whether LIN28B-IGF2BP3 co-binding is required or additive for each target not systematically tested
    • Structural basis of the interaction unknown
  18. 2020 High

    Ribosome profiling resolved the long-standing question of BCL11A regulation by showing that LIN28B directly interacts with ribosomes and BCL11A mRNA to suppress its translation independently of let-7, establishing BCL11A as the major let-7-independent target mediating HbF induction.

    Evidence Ribosome profiling, proteomics, RNA immunoprecipitation, ribosome association assays with let-7-independent controls in primary cells

    PMID:31959994

    Open questions at the time
    • Structural mechanism by which LIN28B blocks BCL11A ribosome transit not determined
    • Whether other mRNAs are similarly translationally repressed by ribosome-associated LIN28B not catalogued
  19. 2020 High

    A let-7-independent transcriptional role for LIN28B was discovered: LIN28B partners with ZNF143 at active promoters to drive adrenergic core regulatory circuitry transcription in neuroblastoma, demonstrated using a let-7-processing-deficient mutant that retained this function.

    Evidence ChIP-seq, reciprocal co-IP, let-7-dead LIN28B mutant, in vivo neuroblastoma penetrance assay

    PMID:32601179

    Open questions at the time
    • Whether LIN28B-ZNF143 co-occupancy occurs outside neuroblastoma not tested
    • Mechanism by which an RNA-binding protein activates transcription at chromatin unclear
  20. 2020 Medium

    KRAS/PKCβ was identified as a signaling axis controlling LIN28B nuclear translocation through direct phosphorylation at S243, linking oncogenic RAS signaling to the compartmentalized mechanism of let-7 suppression.

    Evidence Co-IP, phosphorylation assay, S243 mutagenesis, nuclear fractionation, KRAS/PKCβ manipulation

    PMID:33107691

    Open questions at the time
    • Single lab, not independently confirmed
    • Whether S243 phosphorylation affects let-7-independent functions unknown
    • Other kinases/phosphatases regulating LIN28B localization not explored
  21. 2021 Medium

    LIN28B was identified as an m5C reader that stabilizes NSUN2-methylated GRB2 mRNA, expanding its RNA-binding repertoire beyond sequence/structure recognition to include epitranscriptomic reading.

    Evidence Transcriptome-wide m5C profiling, RIP for LIN28B-GRB2 mRNA, NSUN2 knockout mice, PI3K/AKT and ERK/MAPK pathway assays

    PMID:34345012

    Open questions at the time
    • Single lab; m5C reader function not confirmed by orthogonal structural or biophysical methods
    • Scope of m5C-dependent LIN28B targets not determined
  22. 2022 Medium

    SIRT6 was shown to directly deacetylate LIN28B protein, adding a post-translational acetylation/deacetylation regulatory layer beyond ubiquitination; ALDH2 was found to physically bind LIN28B and compete for ELK3 mRNA binding, revealing protein-protein sequestration as a mechanism limiting LIN28B's mRNA regulatory activity.

    Evidence Co-IP and deacetylation assay for SIRT6-LIN28B; co-IP and RIP for ALDH2-LIN28B-ELK3 axis; endothelial-specific ALDH2 KO

    PMID:35978508 PMID:37822152

    Open questions at the time
    • Acetylation sites on LIN28B not mapped
    • Whether ALDH2 sequestration is specific to endothelial cells not known
    • Each finding from a single lab
  23. 2023 High

    Cryo-EM structures revealed how OCT4 pioneer factor targets the LIN28B-containing nucleosome: three OCT4 molecules bind cooperatively using non-canonical DNA recognition, with POUHD acting as a wedge to unwrap DNA and open H1-condensed chromatin arrays, illuminating the structural basis of LIN28B transcriptional activation in pluripotent cells.

    Evidence Cryo-EM structure determination, biochemical nucleosome binding assays

    PMID:37327775

    Open questions at the time
    • Whether OCT4-nucleosome interactions at LIN28B occur in vivo in embryonic cells not validated by ChIP
    • Functional consequence for LIN28B transcription not directly measured

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include: the structural basis by which ribosome-associated LIN28B selectively represses translation of BCL11A and potentially other mRNAs; the quantitative contribution of let-7-dependent vs. let-7-independent vs. transcriptional (ZNF143) functions in each tissue context; integration of multiple post-translational modifications (ubiquitination, deubiquitylation, phosphorylation, acetylation) into a unified regulatory model; and the physiological role of the LIN28B short isoform.
  • No structural model for LIN28B-ribosome interaction
  • Quantitative partitioning of let-7-dependent vs. independent functions not established
  • Short isoform biology not independently confirmed

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 10 GO:0098772 molecular function regulator activity 3 GO:0140110 transcription regulator activity 1
Localization
GO:0005634 nucleus 3 GO:0005829 cytosol 2
Pathway
R-HSA-1266738 Developmental Biology 4 R-HSA-1643685 Disease 4 R-HSA-74160 Gene expression (Transcription) 4 R-HSA-8953854 Metabolism of RNA 4 R-HSA-168256 Immune System 3 R-HSA-392499 Metabolism of proteins 3
Partners
ALDH2DIS3L2IGF2BP3OTUD6BPKCΒSIRT6TRIM71ZNF143

Evidence

Reading pass · 38 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2011 Unlike Lin28A which acts in the cytoplasm via TUTase (Zcchc11/TUT4) recruitment to pre-let-7, Lin28B functions in the nucleus by sequestering primary let-7 transcripts (pri-let-7) and inhibiting their processing by the Microprocessor, independent of Zcchc11. Knockdown experiments, nuclear fractionation, functional rescue assays, xenograft tumor models Cell High 22118463
2009 c-Myc directly binds the LIN28B promoter (demonstrated by ChIP and reporter assays) and transcriptionally transactivates LIN28B expression, which is necessary and sufficient for Myc-mediated let-7 repression and consequent cellular proliferation. Chromatin immunoprecipitation (ChIP), reporter assays, loss-of-function (siRNA knockdown), gain-of-function overexpression in human and mouse tumor models Proceedings of the National Academy of Sciences of the United States of America High 19211792
2012 LIN28B represses let-7 miRNAs, resulting in elevated MYCN protein expression in neuroblastoma cells, blocking differentiation of neuroblasts; a mouse model with LIN28B expression in the sympathetic adrenergic lineage induced neuroblastoma with low let-7 and high MYCN. In vivo mouse model (transgenic), cell-based knockdown/overexpression, miRNA and protein expression assays Nature genetics High 23042116
2006 LIN28B protein shows cell cycle-dependent nuclear translocation in Huh7 cells, is predominantly cytoplasmic, contains a cold shock domain and CCHC zinc finger domains, and induced expression promotes cancer cell proliferation. Western blot with polyclonal antibody, subcellular fractionation/immunolocalization, tet-off inducible expression system, cell proliferation assay Gene Medium 16971064
2011 LIN28B directly binds LGR5 and PROM1 mRNAs, increasing their expression in a let-7-independent manner, and promotes colon cancer cell migration, invasion, and transformation of immortalized colonic epithelial cells. Overexpression in colonic epithelial and cancer cell lines, let-7 restoration experiments, RNA binding (pulldown), cell migration/invasion assays Oncogene Medium 21625210
2013 PAR-CLIP and iDo-PAR-CLIP identified LIN28B as directly interacting with most expressed mRNAs and pre-let-7 family members at nucleotide resolution; the position of binding sites reflected the structural orientation of individual LIN28B-binding domains (CSD and CCHC zinc fingers); LIN28B knockdown reduced protein synthesis from RNA targets, with the magnitude correlating with binding site location. PAR-CLIP, iDo-PAR-CLIP (individual domain PAR-CLIP), quantitative shotgun proteomics, knockdown experiments RNA biology High 23770886
2013 LIN28B overexpression in adult human erythroblasts reduces let-7 expression, significantly increases fetal hemoglobin (HbF >30% of total hemoglobin) and γ-globin expression, and downregulates BCL11A; conversely, LIN28B knockdown in cord blood erythroblasts reduces HbF. Let-7 suppression independently reduces BCL11A and increases HbF. Lentiviral transduction (knockdown and overexpression), ex vivo erythroblast culture from CD34+ cells, quantitative hemoglobin analysis, gene expression profiling Blood High 23798711
2020 LIN28B directly interacts with ribosomes and BCL11A mRNA and suppresses BCL11A mRNA translation independently of its role in regulating let-7 microRNAs, thereby controlling fetal hemoglobin levels during human hematopoietic development; BCL11A is the major target of LIN28B-mediated HbF induction. Unbiased genomic (ribosome profiling) and proteomic analyses, RNA immunoprecipitation, ribosome association assays, loss-of-function studies with let-7-independent controls Nature genetics High 31959994
2014 LIN28B overexpression is sufficient to initiate hepatoblastoma and hepatocellular carcinoma in murine models; IGF2BP3 is upregulated downstream and required for LIN28B-driven liver cancer growth; intravenous siRNA or conditional deletion of Lin28b reduces tumor burden and prolongs survival. Liver-specific transgenic overexpression, conditional knockout (liver-specific Lin28a/b deletion), intravenous siRNA, xenograft models, survival analysis Cancer cell High 25117712
2013 LIN28B intestinal overexpression causes intestinal hypertrophy, crypt expansion, Paneth cell loss, and polyp/adenocarcinoma formation; CLIP-seq identified direct mRNA binding targets whose protein levels are modestly augmented; let-7-dependent effects predominate, as let-7c2/let-7b deletion recapitulates Lin28b overexpression and intestinal-specific let-7 rescues hypertrophy and Paneth cell depletion caused by Lin28b independently of insulin-PI3K-mTOR signaling. Intestine-targeted transgenic overexpression, mirLet7c2/mirLet7b gene deletion, CLIP-seq (ribonucleoprotein cross-linking and immunoprecipitation), let-7 rescue experiments Genes & development High 24142874
2014 TRIM71 (a TRIM-NHL ubiquitin ligase) negatively regulates LIN28B protein stability by catalyzing its polyubiquitination and proteasomal degradation; a C-terminal ~50 amino acid stretch unique to LIN28B (absent from Lin28A) is essential for TRIM71 interaction and polyubiquitination; the N-terminal RING finger motif of TRIM71 is critical for this interaction, and TRIM71 knockdown reduces let-7 expression through LIN28B stabilization. Co-immunoprecipitation, ubiquitination assay, domain deletion mutagenesis (LIN28B C-terminal truncation, TRIM71 RING mutant), proteasome inhibitor experiments, siRNA knockdown Biochimica et biophysica acta High 24602972
2015 OTUD6B deubiquitylase stabilizes LIN28B as a cell cycle-specific substrate; OTUD6B stabilization of LIN28B drives MYC expression at G1/S phase transition, enabling rapid S-phase entry; OTUD6B or LIN28B silencing inhibits multiple myeloma outgrowth in vivo. DUB screen, substrate identification, co-immunoprecipitation, ubiquitination assay, cell cycle analysis, in vivo xenograft model with shRNA knockdown The EMBO journal High 36059274
2016 SIRT6 loss results in histone hyperacetylation at the LIN28B promoter, Myc recruitment, and LIN28B induction; SIRT6 inactivation accelerates PDAC progression via LIN28B upregulation and downstream let-7 target gene induction (HMGA2, IGF2BP1, IGF2BP3). SIRT6 conditional knockout mouse model, ChIP for histone acetylation and Myc at LIN28B promoter, gene expression profiling, in vivo tumor models Cell High 27180906
2019 Lin28b directly interacts with IGF2BP3 (demonstrated by proteomics and in situ analyses); co-expression of Lin28b and Igf2bp3 in adult HSPCs reactivates fetal-like B-cell development more efficiently than either alone; in B-cell progenitors, Lin28b and Igf2bp3 jointly stabilize thousands of mRNAs (including Pax5 and Arid3a) by binding at the same sites, and Igf2bp3 mRNA forms part of an autoregulatory loop. Single-cell RNA sequencing, proteomics, in situ co-localization, co-expression in vivo, RNA binding site mapping, retroviral overexpression in adult HSPCs Genes & development High 31221665
2015 DIS3 ribonuclease reduces LIN28B mRNA stability in the cytoplasm, thereby facilitating let-7 miRNA maturation; DIS3 inactivation increases LIN28B and reduces mature let-7, enhancing MYC and RAS translation. DIS3 loss-of-function (knockdown/inactivation), LIN28B mRNA stability assay, let-7 maturation assay, polysome/translation analysis Nucleic acids research Medium 25925570
2015 LIN28B is a critical regulator of developmental timing in the murine cochlea; prolonged LIN28B expression delays prosensory cell cycle withdrawal and differentiation causing hair cell and supporting cell patterning defects; LIN28B has let-7-independent functions in the timing of differentiation in this context, as let-7g overexpression induces premature cell cycle exit but not premature HC differentiation. Transgenic mouse models (LIN28B overexpression and let-7g overexpression), Notch inhibition experiments, cell cycle analysis, immunostaining Proceedings of the National Academy of Sciences of the United States of America High 26139524
2016 Lin28b deletion or ectopic let-7 activation in the fetal hematopoietic system induces a shift toward adult-like myeloid-dominant output, while inhibition of let-7 in adults recapitulates fetal erythroid-dominant hematopoiesis; HMGA2 is identified as a downstream effector of the Lin28b-let-7 genetic switch in myeloerythroid development. Lin28b conditional knockout, let-7 inhibitor/mimic in vivo, genetic epistasis with Hmga2 knockdown, flow cytometric analysis of hematopoietic output The Journal of experimental medicine High 27401346
2016 Lin28b overexpression in fetal T cells promotes Treg differentiation by maintaining elevated TGF-β signaling components (TGF-βRI, TGF-βRIII, SMAD2); Lin28b knockdown in fetal T cells decreases Treg differentiation with decreased TGF-β signaling; these TGF-β mediators are let-7 targets, suggesting the mechanism is Lin28b→let-7 suppression→TGF-β signaling components upregulation→enhanced Treg differentiation. Lin28b knockdown in primary fetal T cells, Treg differentiation assay, SMAD phosphorylation analysis, receptor expression measurement Journal of immunology Medium 27793996
2020 LIN28B regulates transcription in neuroblastoma through protein-protein interaction with the sequence-specific zinc-finger transcription factor ZNF143, binding active gene promoters (demonstrated by ChIP-seq and co-immunoprecipitation); this activates adrenergic core regulatory circuitry transcription factors and GSK3B/L1CAM; a let-7-processing-deficient LIN28B mutant retains this function, establishing a let-7-independent transcriptional mechanism. ChIP-seq, co-immunoprecipitation, let-7-processing-deficient LIN28B mutant overexpression, in vivo neuroblastoma penetrance assay, invasion/migration assays Proceedings of the National Academy of Sciences of the United States of America High 32601179
2015 The uridylation pathway participates in LIN28B-mediated let-7 blockade: both Lin28A and Lin28B interact with Dis3l2 in the cytoplasm; Dis3l2 silencing upregulates uridylated pre-let-7 in Lin28B-expressing cancer cells; amounts of let-7 precursors influence intracellular localization of Lin28B; MCPIP1 ribonuclease also degrades uridylated and non-uridylated pre-let-7. Co-immunoprecipitation (Lin28B-Dis3l2 interaction), siRNA knockdown of Dis3l2/MCPIP1, pre-let-7 uridylation quantification, subcellular fractionation Cancer science Medium 26080928
2020 KRAS promotes LIN28B nuclear translocation through PKCβ, which directly binds to and phosphorylates LIN28B at S243; nuclear LIN28B blocks mature let-7i production, increasing TET3 mRNA/protein levels; elevated TET3 promotes Lin28B expression forming a Lin28B/let-7i/TET3 feedback loop. Co-immunoprecipitation, phosphorylation assay, nuclear fractionation, site-directed mutagenesis (S243), overexpression and knockdown of KRAS/PKCβ/LIN28B/TET3, let-7i quantification Molecular oncology Medium 33107691
2021 NSUN2 methyltransferase induces m5C modification of GRB2 mRNA; LIN28B acts as a novel m5C reader mediating stabilization of GRB2 mRNA, elevating GRB2 protein levels and activating PI3K/AKT and ERK/MAPK signaling. Transcriptome-wide m5C profiling (bisulfite sequencing), RIP (LIN28B-GRB2 mRNA interaction), NSUN2 knockout mouse models, pathway activation assays Oncogene Medium 34345012
2018 LIN28B binds AKT2 mRNA and enhances its protein expression; this elevates AKT2 activity, leading to FOXO3A phosphorylation and decreased BIM transcription, thereby inhibiting apoptosis in ovarian cancer cells. RNA-IP microarray (RIP-chip) to identify LIN28B-bound mRNAs, Western blot for AKT2/FOXO3A/BIM, overexpression/knockdown functional assays, apoptosis assays Signal transduction and targeted therapy Medium 30174831
2018 LIN28B directly binds to NRP-1 3'UTR, stabilizing NRP-1 mRNA and activating downstream Wnt/β-catenin signaling to promote gastric cancer cell stemness. RNA immunoprecipitation (direct binding assay), mRNA stability assay, Wnt/β-catenin pathway inhibitor rescue, knockdown/overexpression functional assays Biomedicine & pharmacotherapy Medium 29787985
2023 OCT4 targets LIN28B chromatin: high-resolution cryo-EM structures show three OCT4 molecules binding the LIN28B-containing nucleosome via non-canonical DNA sequences; two OCT4s use their POUS domains and one uses POUS-loop-POUHD, with POUHD acting as a wedge to unwrap ~25 bp DNA; multiple OCT4s cooperatively open H1-condensed nucleosome arrays containing the LIN28B nucleosome. Cryo-EM structure determination, biochemical nucleosome binding assays, genomic data analysis, ESRRB-nucleosome-OCT4 structure determination Molecular cell High 37327775
2009 N-Myc directly binds to the LIN28B gene region and regulates LIN28B expression in neuroblastoma, established by ChIP-chip assay; N-Myc levels closely correlate with LIN28B expression in both neuroblastoma cells and neural stem cells with N-myc knockout. ChIP-chip assay, Tet-regulatable N-myc transgene, nestin-cre N-myc knockout, expression correlation PloS one Medium 19495417
2015 MYCN regulates LIN28B expression in neuroblastoma via two parallel mechanisms: (1) indirectly through miR-26a-5p (MYCN suppresses miR-26a-5p which normally targets LIN28B 3'UTR, demonstrated by 3'UTR reporter screen and ChIP); (2) directly by interacting with the LIN28B promoter (demonstrated by ChIP). LIN28B-3'UTR reporter screen, ChIP (MYCN at LIN28B promoter and miR-26a-5p locus), miRNA overexpression, MYCN-inducible cell system Cancer letters Medium 26123663
2015 MacroH2A1 suppresses LIN28B expression through macroH2A1-mediated reciprocal binding of p300 and EZH2/SUV39H1 at the LIN28B locus; macroH2A1 knockdown elevates LIN28B, which then inhibits mature let-7, promoting bladder cancer stem-like properties. MacroH2A1 knockdown, ChIP for p300/EZH2/SUV39H1 at LIN28B locus, LIN28B stable overexpression, let-7 quantification, tumorigenicity assays Oncogene Medium 26028027
2018 MUC1-C promotes NF-κB p65 chromatin occupancy at the LIN28B first intron and activates LIN28B transcription; this suppresses let-7 and increases HMGA2, promoting EMT and self-renewal in NSCLC. MUC1-C dominant-negative mutant, peptide inhibitor, ChIP (NF-κB p65 at LIN28B intron 1), siRNA knockdown, self-renewal assays Molecular cancer research Medium 25368430
2015 IKKβ enhances LIN28B expression through TCF7L2 (TCF4), which directly binds to intron 1 of the LIN28B gene; LIN28B in turn promotes TCF7L2 mRNA translation, forming a positive feedback loop that sustains cancer cell stemness and metastasis. Overexpression/knockdown of LIN28B and IKKβ, ChIP (TCF7L2 at LIN28B intron 1), mRNA translation assay, in vivo tumor/metastasis model, pharmacological IKKβ inhibition Cancer research Medium 25744721
2016 Lin28b controls B cell positive selection by amplifying the CD19/PI3K/c-Myc positive feedback loop; ectopic Lin28b expression in adult mice restores both positive selection and mature B cell numbers in CD19-/- adult mice, demonstrating epistasis downstream of CD19. Transgenic Lin28b overexpression in adult mice, CD19 knockout genetic rescue, flow cytometric B cell development analysis, BCR signaling measurement Science immunology High 31562190
2022 Sirt6 directly interacts with and deacetylates Lin28b; Sirt6 overexpression decreases Lin28b expression and suppresses vascular endothelial cell pyroptosis by negatively regulating the Lin28b/let-7 pathway in atherosclerosis. Co-immunoprecipitation (Sirt6-Lin28b interaction), deacetylation assay, Sirt6 overexpression, Lin28b knockdown, pyroptosis assays (PI staining, GSDMD cleavage, LDH/IL-1β release), ApoE-/- HFD mouse model International immunopharmacology Medium 35978508
2013 HBx activates Lin28A through Sp-1 binding element via direct protein-protein interaction with Sp-1 (demonstrated by co-IP, ChIP, EMSA); HBx activates Lin28B through c-Myc; Lin28A/B are required for HBx-enhanced proliferation of hepatoma cells in vitro and in vivo. Co-immunoprecipitation, chromatin immunoprecipitation (ChIP), electrophoretic mobility shift assay (EMSA), siRNA knockdown, in vivo tumor model Oncogene Medium 23318446
2020 LIN28B regulates the stability of EWS-FLI1 mRNA in a subset (~10%) of Ewing sarcomas; LIN28B depletion decreases EWS-FLI1 expression and its transcriptional network, abrogating self-renewal and tumorigenicity; pharmacological inhibition of LIN28B/let-7 binding mimics this effect. LIN28B knockdown, mRNA stability assay for EWS-FLI1, pharmacological LIN28B inhibition, self-renewal and tumorigenicity assays, CTC-derived cell line models Cell reports Medium 32234488
2018 LIN28B-long isoform suppresses LET-7 and activates RAS/ERK signaling, whereas the LIN28B-short isoform binds pre-let-7 without inhibiting LET-7 maturation and competes with the long isoform for pre-let-7 binding, thereby acting as an antagonist to the long isoform's oncogenic functions. Isoform-specific expression in colorectal cancer cells, LET-7 quantification, RAS/ERK pathway assays, pre-let-7 binding competition assays, drug resistance assays Molecular cancer research Medium 29330293
2022 ALDH2 directly binds to LIN28B, hindering LIN28B binding to ELK3 mRNA and suppressing ELK3 expression, thereby impairing endothelial barrier function; this ALDH2-LIN28B-ELK3 axis modulates early AAA progression. Co-immunoprecipitation (ALDH2-LIN28B), RNA immunoprecipitation (LIN28B-ELK3 mRNA), ALDH2 endothelial-specific KO, single-cell RNA sequencing, mRNA sequencing Advanced science Medium 37822152
2022 Lin28b/let-7 axis controls developmental maturation of hematopoietic stem and progenitor cells; the Polycomb repressor complex 1 component Cbx2 is an effector downstream of Lin28b/let-7, regulating developmental timing of key hematopoietic transcription factor expression; juvenile Cbx2-/- hematopoietic tissues show precocious adult-like myeloid bias and impaired B-lymphopoiesis. Transcriptomic data mining, gene regulatory network reconstruction, Cbx2 knockout, hematopoietic lineage output analysis by flow cytometry Cell reports Medium 35385744
2023 LIN28B directly binds and posttranscriptionally regulates CLDN1 (claudin 1) mRNA, demonstrated by RNA immunoprecipitation; LIN28B-mediated CLDN1 expression promotes collective invasion, cell migration, and metastatic liver tumor formation; NOTCH3 acts as a downstream effector of the LIN28B/CLDN1 axis. RNA immunoprecipitation (LIN28B-CLDN1 mRNA), LIN28B knockdown/overexpression, bulk RNA sequencing of metastatic tumors, murine metastatic CRC model, NOTCH3 genetic and pharmacological manipulation JCI insight Medium 37318881

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2011 Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms. Cell 528 22118463
2009 Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation. Proceedings of the National Academy of Sciences of the United States of America 329 19211792
2012 LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression. Nature genetics 322 23042116
2009 Genetic variation in LIN28B is associated with the timing of puberty. Nature genetics 267 19448623
2006 Identification and characterization of lin-28 homolog B (LIN28B) in human hepatocellular carcinoma. Gene 253 16971064
2012 Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma. Nature genetics 228 22941191
2016 SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b. Cell 223 27180906
2011 LIN28B promotes colon cancer progression and metastasis. Cancer research 208 21512136
2014 Lin28b is sufficient to drive liver cancer and necessary for its maintenance in murine models. Cancer cell 171 25117712
2011 Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers. PloS one 162 21533284
2021 NSUN2-mediated RNA 5-methylcytosine promotes esophageal squamous cell carcinoma progression via LIN28B-dependent GRB2 mRNA stabilization. Oncogene 155 34345012
2015 Aberrant regulation of the LIN28A/LIN28B and let-7 loop in human malignant tumors and its effects on the hallmarks of cancer. Molecular cancer 154 26123544
2013 LIN28B-mediated expression of fetal hemoglobin and production of fetal-like erythrocytes from adult human erythroblasts ex vivo. Blood 120 23798711
2013 LIN28B promotes growth and tumorigenesis of the intestinal epithelium via Let-7. Genes & development 112 24142874
2011 LIN28B fosters colon cancer migration, invasion and transformation through let-7-dependent and -independent mechanisms. Oncogene 112 21625210
2018 TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression. Nature communications 109 29748571
2016 The oncogenic triangle of HMGA2, LIN28B and IGF2BP1 antagonizes tumor-suppressive actions of the let-7 family. Nucleic acids research 103 26917013
2013 miR-26a enhances miRNA biogenesis by targeting Lin28B and Zcchc11 to suppress tumor growth and metastasis. Oncogene 99 24056962
2020 Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation. Nature genetics 89 31959994
2010 Lin-28B expression promotes transformation and invasion in human hepatocellular carcinoma. Carcinogenesis 89 20525879
2020 LINC00665 promotes breast cancer progression through regulation of the miR-379-5p/LIN28B axis. Cell death & disease 80 31907362
2009 N-Myc regulates expression of pluripotency genes in neuroblastoma including lif, klf2, klf4, and lin28b. PloS one 78 19495417
2012 Lin28b promotes head and neck cancer progression via modulation of the insulin-like growth factor survival pathway. Oncotarget 77 23482325
2016 The LIN28B/let-7 axis is a novel therapeutic pathway in multiple myeloma. Leukemia 76 27773931
2020 Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target. Nature communications 71 32620742
2019 Targeting LIN28B reprograms tumor glucose metabolism and acidic microenvironment to suppress cancer stemness and metastasis. Oncogene 69 30742065
2017 Inhibition of LIN28B impairs leukemia cell growth and metabolism in acute myeloid leukemia. Journal of hematology & oncology 66 28693523
2016 Developmental regulation of myeloerythroid progenitor function by the Lin28b-let-7-Hmga2 axis. The Journal of experimental medicine 63 27401346
2014 MUC1-C Induces the LIN28B→LET-7→HMGA2 Axis to Regulate Self-Renewal in NSCLC. Molecular cancer research : MCR 61 25368430
2020 Loss of hnRNPA2B1 inhibits malignant capability and promotes apoptosis via down-regulating Lin28B expression in ovarian cancer. Cancer letters 59 32006618
2013 Hepatitis B virus X protein upregulates Lin28A/Lin28B through Sp-1/c-Myc to enhance the proliferation of hepatoma cells. Oncogene 56 23318446
2013 Identification of LIN28B-bound mRNAs reveals features of target recognition and regulation. RNA biology 56 23770886
2018 Decreased LIN28B in preeclampsia impairs human trophoblast differentiation and migration. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 55 30307771
2019 Enhancement of LIN28B-induced hematopoietic reprogramming by IGF2BP3. Genes & development 54 31221665
2017 Targeting the miR-200c/LIN28B axis in acquired EGFR-TKI resistance non-small cell lung cancer cells harboring EMT features. Scientific reports 53 28084458
2018 RNA-binding protein LIN28B inhibits apoptosis through regulation of the AKT2/FOXO3A/BIM axis in ovarian cancer cells. Signal transduction and targeted therapy 51 30174831
2019 The transcribed pseudogene RPSAP52 enhances the oncofetal HMGA2-IGF2BP2-RAS axis through LIN28B-dependent and independent let-7 inhibition. Nature communications 49 31484926
2016 miR-26a suppresses EMT by disrupting the Lin28B/let-7d axis: potential cross-talks among miRNAs in IPF. Journal of molecular medicine (Berlin, Germany) 48 26787543
2015 IKKβ Enforces a LIN28B/TCF7L2 Positive Feedback Loop That Promotes Cancer Cell Stemness and Metastasis. Cancer research 44 25744721
2015 MYCN-driven regulatory mechanisms controlling LIN28B in neuroblastoma. Cancer letters 43 26123663
2016 Potentially functional polymorphisms in the LIN28B gene contribute to neuroblastoma susceptibility in Chinese children. Journal of cellular and molecular medicine 42 27021521
2016 Lin28b Regulates Fetal Regulatory T Cell Differentiation through Modulation of TGF-β Signaling. Journal of immunology (Baltimore, Md. : 1950) 42 27793996
2022 Follistatin promotes LIN28B-mediated supporting cell reprogramming and hair cell regeneration in the murine cochlea. Science advances 41 35148175
2018 LncRNA H19-elevated LIN28B promotes lung cancer progression through sequestering miR-196b. Cell cycle (Georgetown, Tex.) 41 29950144
2014 The ubiquitin ligase human TRIM71 regulates let-7 microRNA biogenesis via modulation of Lin28B protein. Biochimica et biophysica acta 40 24602972
2018 Long non-coding RNA UFC1 promotes gastric cancer progression by regulating miR-498/Lin28b. Journal of experimental & clinical cancer research : CR 39 29970131
2016 Suppression of lethal-7b and miR-125a/b Maturation by Lin28b Enables Maintenance of Stem Cell Properties in Hepatoblasts. Hepatology (Baltimore, Md.) 39 26990797
2015 The RNA-binding protein LIN28B regulates developmental timing in the mammalian cochlea. Proceedings of the National Academy of Sciences of the United States of America 39 26139524
2012 Functional study of risk loci of stem cell-associated gene lin-28B and associations with disease survival outcomes in epithelial ovarian cancer. Carcinogenesis 39 22822098
2017 miR-203 enhances let-7 biogenesis by targeting LIN28B to suppress tumor growth in lung cancer. Scientific reports 38 28218277
2020 LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors. Proceedings of the National Academy of Sciences of the United States of America 37 32601179
2020 LIN28B-AS1-IGF2BP1 binding promotes hepatocellular carcinoma cell progression. Cell death & disease 37 32917856
2014 The heterochronic genes lin-28a and lin-28b play an essential and evolutionarily conserved role in early zebrafish development. PloS one 37 24516585
2020 CircBPTF knockdown ameliorates high glucose-induced inflammatory injuries and oxidative stress by targeting the miR-384/LIN28B axis in human umbilical vein endothelial cells. Molecular and cellular biochemistry 36 32524321
2019 Osteosarcoma-initiating cells show high aerobic glycolysis and attenuation of oxidative phosphorylation mediated by LIN28B. Cancer science 36 31705593
2014 Genetic variants of the LIN28B gene predict severe radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy. European journal of cancer (Oxford, England : 1990) 36 24780874
2010 LIN28B in constitutional delay of growth and puberty. The Journal of clinical endocrinology and metabolism 35 20350940
2011 LIN28B, LIN28A, KISS1, and KISS1R in idiopathic central precocious puberty. BMC research notes 34 21939553
2018 RNA binding protein Lin28B confers gastric cancer cells stemness via directly binding to NRP-1. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 33 29787985
2015 MacroH2A1 downregulation enhances the stem-like properties of bladder cancer cells by transactivation of Lin28B. Oncogene 33 26028027
2016 LIN28B Activation by PRL-3 Promotes Leukemogenesis and a Stem Cell-like Transcriptional Program in AML. Molecular cancer research : MCR 32 28011885
2015 Lin28B and Let-7 in the Control of Sympathetic Neurogenesis and Neuroblastoma Development. The Journal of neuroscience : the official journal of the Society for Neuroscience 30 26674877
2014 LIN28B promotes colon cancer migration and recurrence. PloS one 30 25360631
2012 Investigation of peripubertal expression of Lin28a and Lin28b in C57BL/6 female mice. Molecular and cellular endocrinology 30 23138112
2019 LIN28B increases neural crest cell migration and leads to transformation of trunk sympathoadrenal precursors. Cell death and differentiation 29 31601998
2018 A LIN28B Tumor-Specific Transcript in Cancer. Cell reports 29 29466730
2015 The ribonuclease DIS3 promotes let-7 miRNA maturation by degrading the pluripotency factor LIN28B mRNA. Nucleic acids research 29 25925570
2019 miR-152/LIN28B axis modulates high-glucose-induced angiogenesis in human retinal endothelial cells via VEGF signaling. Journal of cellular biochemistry 28 31609010
2023 Structural mechanism of LIN28B nucleosome targeting by OCT4. Molecular cell 27 37327775
2015 A role of uridylation pathway for blockade of let-7 microRNA biogenesis by Lin28B. Cancer science 26 26080928
2020 LIN28B promotes neuroblastoma metastasis and regulates PDZ binding kinase. Neoplasia (New York, N.Y.) 25 32339949
2019 Neoplastic Transformation of Human Mesenchymal Stromal Cells Mediated via LIN28B. Scientific reports 25 31147574
2017 MicroRNA-125b-5p mediates post-transcriptional regulation of hepatitis B virus replication via the LIN28B/let-7 axis. RNA biology 25 28267418
2012 Absence of functional LIN28B mutations in a large cohort of patients with idiopathic central precocious puberty. Hormone research in paediatrics 25 22964795
2016 TRIM71 suppresses tumorigenesis via modulation of Lin28B-let-7-HMGA2 signaling. Oncotarget 24 27821801
2022 Sirt6 inhibits vascular endothelial cell pyroptosis by regulation of the Lin28b/let-7 pathway in atherosclerosis. International immunopharmacology 23 35978508
2020 The KRAS/Lin28B axis maintains stemness of pancreatic cancer cells via the let-7i/TET3 pathway. Molecular oncology 23 33107691
2021 Circ-FBXW12 aggravates the development of diabetic nephropathy by binding to miR-31-5p to induce LIN28B. Diabetology & metabolic syndrome 21 34863268
2017 The correlation between LIN28B gene potentially functional variants and Wilms tumor susceptibility in Chinese children. Journal of clinical laboratory analysis 21 28301057
2017 MicroRNA-4458 suppresses the proliferation of human lung cancer cells in vitro by directly targeting Lin28B. Acta pharmacologica Sinica 21 28603287
2017 Lin28B and miR-142-3p regulate neuronal differentiation by modulating Staufen1 expression. Cell death and differentiation 21 29099484
2014 A potential regulatory loop between Lin28B:miR‑212 in androgen-independent prostate cancer. International journal of oncology 21 25201220
2022 Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-Cbx2 axis. Cell reports 20 35385744
2022 The OTUD6B-LIN28B-MYC axis determines the proliferative state in multiple myeloma. The EMBO journal 20 36059274
2021 The LIN28B/TGF-β/TGFBI feedback loop promotes cell migration and tumour initiation potential in cholangiocarcinoma. Cancer gene therapy 20 34548635
2020 Propofol‑induced miR‑125a‑5p inhibits the proliferation and metastasis of ovarian cancer by suppressing LIN28B. Molecular medicine reports 20 32627014
2019 Lin28b controls a neonatal to adult switch in B cell positive selection. Science immunology 20 31562190
2017 Lin28B facilitates the progression and metastasis of pancreatic ductal adenocarcinoma. Oncotarget 20 28947981
2015 Lin28B over-expression mediates the repression of let-7 by hepatitis B virus X protein in hepatoma cells. International journal of clinical and experimental medicine 20 26628994
2012 Association of LIN28B with adult adiposity-related traits in females. PloS one 20 23152804
2023 Early Progression of Abdominal Aortic Aneurysm is Decelerated by Improved Endothelial Barrier Function via ALDH2-LIN28B-ELK3 Signaling. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 19 37822152
2022 LOC101929709 promotes gastric cancer progression by aiding LIN28B to stabilize c-MYC mRNA. Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 19 36284068
2020 LIN28B Underlies the Pathogenesis of a Subclass of Ewing Sarcoma LIN28B Control of EWS-FLI1 Stability. Cell reports 19 32234488
2018 Modulation of LIN28B/Let-7 Signaling by Propranolol Contributes to Infantile Hemangioma Involution. Arteriosclerosis, thrombosis, and vascular biology 19 29724816
2022 lncRNA LUCAT1/ELAVL1/LIN28B/SOX2 Positive Feedback Loop Promotes Cell Stemness in Triple-Negative Breast Cancer. The breast journal 18 35711895
2020 Lin28B/miR-92b Promote the Proliferation, Migration, and Invasion in the Pathogenesis of Preeclampsia via the DKK1/Wnt/β-Catenin Pathway. Reproductive sciences (Thousand Oaks, Calif.) 18 32072603
2016 Association of genetic polymorphisms around the LIN28B gene and idiopathic central precocious puberty risks among Chinese girls. Pediatric research 18 27304100
2023 LIN28B promotes cell invasion and colorectal cancer metastasis via CLDN1 and NOTCH3. JCI insight 17 37318881
2023 N6-methyladenosine-mediated overexpression of long noncoding RNA ADAMTS9-AS2 triggers neuroblastoma differentiation via regulating LIN28B/let-7/MYCN signaling. JCI insight 17 37991019
2018 Differential Regulation of LET-7 by LIN28B Isoform-Specific Functions. Molecular cancer research : MCR 17 29330293