Affinage

KLC2

Kinesin light chain 2 · UniProt Q9H0B6

Length
622 aa
Mass
68.9 kDa
Annotated
2026-06-10
43 papers in source corpus 21 papers cited in narrative 21 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

KLC2 is the cargo-binding light chain subunit of the kinesin-1 microtubule motor, coupling diverse membrane and protein cargoes to the heavy chain for directional transport along axons and within cells (PMID:15563606, PMID:18361505). Cargo recognition is mediated by the TPR domain of KLC2, which binds bipartite tryptophan-based (W-acidic) motifs present in over 450 human proteins and in viral proteins, with individual cargoes showing distinct preferences for KLC1 versus KLC2 (PMID:21915095). Crystal structures of the KLC2 TPR domain define a common cargo-binding groove and explain isoform-specific selectivity: residue S328 (corresponding to KLC1 N343) lacks the carboxylate clamp required for JIP1 binding, and a structurally plastic N-terminal capping helix adopts alternative orientations that modulate the groove surface and cargo versatility (PMID:22470497, PMID:29036226). Through this groove KLC2 recruits cargoes including AMPA-receptor (GluR1) vesicles (PMID:20534517), the TGF-β effector Smad2 (PMID:21996745, PMID:41502514), the sodium/iodide symporter NIS (PMID:33912899), melanosomes via Rab1A/SKIP (PMID:25649263), and the nucleoporin Nup358, where KLC2 forms a 2:2:2 complex with the dynein adaptor BicD2 to permit simultaneous bidirectional motor recruitment to the nuclear pore (PMID:31756096). Cargo loading is switched by phosphorylation: GSK-3β phosphorylates KLC2 on serine residues to dissociate cargo such as GluR1 vesicles, an event controlled upstream by LMTK2, which acts through PP1C to increase inhibitory phosphorylation of GSK-3β and thereby promote Smad2 binding to KLC2 (PMID:20534517, PMID:21996745); 14-3-3 binds KLC2 in a phosphorylation-dependent manner at Ser575 (PMID:11969417). KLC2 supports kinesin-1–dependent anterograde transport of herpesvirus particles in axons (PMID:30068641), and in C. elegans the KLC-2 orthologue partners with the KASH protein UNC-83 and adaptors UNC-16/UNC-14/UNC-33 to drive nuclear migration and synaptic-cargo localization, with distinct UNC-83 isoforms toggling between kinesin-1 activation and dynein-mediated transport (PMID:19605495, PMID:15563606, PMID:40925371). A homozygous regulatory deletion that elevates KLC2 expression causes SPOAN syndrome, and Klc2 loss in mice produces sensorineural hearing loss rescuable by gene delivery (PMID:26385635, PMID:34014435).

Mechanistic history

Synthesis pass · year-by-year structured walk · 17 steps
  1. 2002 Medium

    Established that KLC2 is regulated post-translationally by phosphorylation-dependent adaptor binding, linking the motor light chain to signaling control.

    Evidence Proteomic pulldown and MS site mapping of 14-3-3 binding to KLC2 in PC12 cells

    PMID:11969417

    Open questions at the time
    • Functional consequence of Ser575 phosphorylation for cargo transport not defined
    • Kinase responsible for Ser575 phosphorylation not identified
  2. 2004 High

    Defined a conserved kinesin-1 cargo pathway by placing KLC-2 with the heavy chain and the adaptors UNC-16 and UNC-14 in one genetic pathway controlling synaptic-vesicle localization.

    Evidence Reciprocal Co-IP, double-mutant epistasis, and marker localization in C. elegans

    PMID:15563606

    Open questions at the time
    • Direct binding interface on KLC-2 not mapped
    • Conservation of adaptor binding to human KLC2 not tested
  3. 2005 Medium

    Extended KLC-2 cargo range to a CRMP-family protein required for neurite outgrowth, showing kinesin-1 carries cytoskeletal regulators.

    Evidence In vivo Co-IP and mutant mislocalization analysis in C. elegans

    PMID:16236031

    Open questions at the time
    • Whether UNC-33 binds KLC-2 directly or via UNC-14 unresolved
  4. 2008 Medium

    Clarified holoenzyme architecture, showing kinesin-1 forms homodimers with homodimerized KLC subunits and that heavy-chain isoforms, not KLC1/KLC2 choice, drive organelle targeting.

    Evidence Reciprocal Co-IP and subcellular fractionation from brain tissue

    PMID:18361505

    Open questions at the time
    • Functional distinction between KLC1- and KLC2-containing holoenzymes not resolved here
  5. 2010 Medium

    Identified the phosphorylation switch that releases cargo, showing GSK-3β phosphorylation of KLC2 dissociates AMPA-receptor vesicles and modulates synaptic plasticity.

    Evidence Phosphorylation and Co-IP assays plus peptide inhibitor with behavioral readouts in mice

    PMID:20534517

    Open questions at the time
    • Exact GSK-3β target serines on KLC2 not fully mapped
    • Generality of phospho-release across cargoes untested
  6. 2011 Medium

    Mapped the upstream signaling that controls KLC2 cargo binding, showing LMTK2–PP1C inhibition of GSK-3β promotes Smad2 loading and TGF-β nuclear signaling.

    Evidence siRNA knockdown, Co-IP, and TGF-β signaling readouts

    PMID:21996745

    Open questions at the time
    • Direct phosphosite linkage between GSK-3β activity and Smad2 binding not resolved
  7. 2011 Medium

    Defined the general cargo-recognition code, identifying a bipartite W-acidic motif that binds KLC1/KLC2 with isoform preference and is sufficient to recruit kinesin-1 to cargo.

    Evidence Bioinformatics, Co-IP, and functional transport assays using vaccinia as surrogate cargo

    PMID:21915095

    Open questions at the time
    • Structural basis of KLC1 vs KLC2 preference not yet resolved in this study
  8. 2012 High

    Provided the structural basis for KLC isoform-specific cargo selectivity, defining a shared TPR groove and the S328-vs-N343 difference that excludes JIP1 from KLC2.

    Evidence X-ray crystallography of KLC1/KLC2 TPR domains with ITC binding

    PMID:22470497

    Open questions at the time
    • Capping helix contribution not yet characterized
    • Phospho-regulation not captured in the structures
  9. 2015 Medium

    Showed KLC2 mediates organelle transport, recruiting melanosomes via a Rab1A/SKIP effector chain.

    Evidence Co-IP, knockdown with transport phenotype, and melanosome live imaging

    PMID:25649263

    Open questions at the time
    • Direct W-acidic motif on SKIP engaging KLC2 not mapped here
  10. 2015 Medium

    Linked KLC2 dosage to human disease, establishing that a regulatory deletion raising KLC2 expression causes SPOAN syndrome.

    Evidence Whole-genome sequencing, luciferase reporter, and zebrafish gain/loss-of-function with patient cell expression

    PMID:26385635

    Open questions at the time
    • Mechanism by which KLC2 overexpression injures motor neurons unknown
    • Affected cargo(es) driving pathology not identified
  11. 2017 Medium

    Revealed an additional modulator of cargo binding, showing the N-terminal capping helix of the TPR domain adopts two orientations that reshape the binding groove.

    Evidence X-ray crystallography and comparative structural analysis

    PMID:29036226

    Open questions at the time
    • Functional role of capping-helix orientations not tested by mutagenesis
    • Which cargoes select each orientation unknown
  12. 2018 Medium

    Demonstrated KLC2 (with KLC1 and KIF5 heavy chains) is required for anterograde axonal transport of an enveloped virus, distinguishing kinesin-1 from kinesin-3 dependence.

    Evidence siRNA silencing, colocalization, and live imaging of HSV transport in axons

    PMID:30068641

    Open questions at the time
    • Viral cargo motif engaging KLC2 not defined
  13. 2019 High

    Reconstituted bidirectional motor recruitment, showing KLC2 and the dynein adaptor BicD2 bind Nup358 simultaneously to form a 2:2:2 complex at the nuclear pore.

    Evidence In vitro reconstitution, W-acidic motif mutagenesis, and stoichiometry determination

    PMID:31756096

    Open questions at the time
    • How opposing motors are coordinated in vivo not established
  14. 2021 Medium

    Identified KLC2 as essential for cargo maturation and surface delivery, showing it transports NIS via a W-acidic motif and that loss causes hypothyroidism.

    Evidence Interaction assays, iodide uptake, siRNA in thyroid cells, and zebrafish morpholino knockdown

    PMID:33912899

    Open questions at the time
    • Structural basis of NIS motif recognition by KLC2 not solved
  15. 2021 Medium

    Established a physiological requirement for KLC2 in cochlear function via mitochondrial transport and GABAA-receptor maintenance, rescuable by gene delivery.

    Evidence Klc2 knockout mouse, ABR thresholds, immunostaining, and AAV rescue

    PMID:34014435

    Open questions at the time
    • Direct KLC2 cargo responsible for the hair-cell phenotype not identified
  16. 2025 Medium

    Resolved isoform-level regulation of motor selection, showing UNC-83 isoforms either activate kinesin-1 by binding KLC-2 or inhibit it to favor dynein transport.

    Evidence C. elegans genetic epistasis, in vitro binding, and AlphaFold prediction with genetic validation

    PMID:40925371

    Open questions at the time
    • Conservation of this isoform switch to human KLC2 untested
  17. 2025 Medium

    Connected KLC2 mutation to cancer signaling, showing CML blast-phase mutants disrupt TGF-β/SMAD2 signaling and enhance STAT3 phosphorylation despite retaining SMAD2 binding.

    Evidence Co-IP, signaling immunoblots, proliferation/apoptosis assays, and xenograft

    PMID:41502514

    Open questions at the time
    • How mutant KLC2 redirects SMAD2 transport mechanistically unresolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • How phospho-switches, the capping helix, and competing W-acidic cargoes are integrated to set KLC2 cargo priority in living human cells remains unresolved.
  • No structure of KLC2 bound to a physiological cargo motif in the human context
  • Phospho-regulatory map across all KLC2 cargoes incomplete
  • In vivo coordination of kinesin-1 vs dynein recruitment not directly observed in mammalian cells

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 4 GO:0038024 cargo receptor activity 3 GO:0008092 cytoskeletal protein binding 2
Localization
GO:0005635 nuclear envelope 2 GO:0005829 cytosol 2 GO:0005856 cytoskeleton 2
Pathway
R-HSA-9609507 Protein localization 3 R-HSA-162582 Signal Transduction 2 R-HSA-5653656 Vesicle-mediated transport 2
Partners
14-3-3BICD2GLUR1KIF5BNUP358SKIPSMAD2UNC-83
Complex memberships
kinesin-1

Evidence

Reading pass · 21 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2002 14-3-3 protein directly binds to kinesin heterodimers through interaction with KLC2, and this interaction is phosphorylation-dependent. Mass spectrometry identified Ser575 as the phosphorylation site on KLC2 responsible for the in vivo interaction with 14-3-3. Proteomic pulldown from PC12 cells expressing myc-tagged 14-3-3eta, SDS-PAGE/mass spectrometry, interaction studies with KLC2 variants in cultured cells Biochemistry Medium 11969417
2008 Conventional kinesin holoenzymes are composed of kinesin-1 homodimers (not heterodimers), and KLC subunits also homodimerize. No specificity was found between kinesin-1 isoforms and KLC1/KLC2, suggesting six variant forms of kinesin exist. Different variants associate with biochemically distinct membrane-bounded organelles (MBOs), suggesting kinesin-1 heavy chains target the holoenzyme to specific cargoes. Immunoprecipitation from brain tissue, subcellular fractionation Biochemistry Medium 18361505
2010 GSK-3β phosphorylates KLC2 on serine residues upon AMPA stimulation, causing dissociation of the GluR1/KLC2 protein complex and release of AMPA-containing vesicles from the kinesin cargo system. A peptide inhibitor of KLC2 phosphorylation (TAT-KLCpCDK) reduced long-term depression formation. Phosphorylation assays, co-immunoprecipitation, peptide inhibitor experiments in neuronal cells, behavioral assays in mice Proceedings of the National Academy of Sciences of the United States of America Medium 20534517
2011 LMTK2 signals via protein phosphatase-1C (PP1C) to increase inhibitory phosphorylation of GSK-3β on serine-9, which reduces KLC2 phosphorylation by GSK-3β and promotes binding of the cargo Smad2 to KLC2. siRNA knockdown of LMTK2 reduces Smad2 binding to KLC2 and inhibits TGFβ-induced Smad2 nuclear signalling. siRNA knockdown, co-immunoprecipitation, phosphorylation assays, TGFβ signaling readouts Oncogene Medium 21996745
2011 A bipartite tryptophan-based (W-acidic) motif present in vaccinia protein A36 and in over 450 human proteins mediates binding to KLC1 and KLC2. Different proteins containing this motif show distinct preferences for KLC1 versus KLC2. Regions containing this motif from cellular proteins can functionally recruit KLC and promote kinesin-1-dependent virus transport. Bioinformatic analysis, functional transport assays using vaccinia as surrogate cargo, co-immunoprecipitation outside infection context The EMBO journal Medium 21915095
2012 Crystal structures of the TPR domains of KLC1 and KLC2 were determined by X-ray crystallography. KLC2 residue S328 (corresponding to N343 in KLC1) lacks the ability to form a 'carboxylate clamp' for JIP1 binding, explaining why KLC2, unlike KLC1, does not interact with JIP1. A common groove in both KLC1 and KLC2 TPR domains mediates binding of shared cargoes. X-ray crystallography, isothermal titration calorimetry PloS one High 22470497
2009 In C. elegans, the KASH protein UNC-83 interacts with kinesin-1 light chain KLC-2 (identified by yeast two-hybrid and confirmed by in vitro assays), recruits KLC-2 to the nuclear envelope in heterologous tissue culture, and acts as a cargo adaptor for kinesin-1-dependent nuclear migration. A synthetic KLC-2::KASH fusion protein could partially bypass the requirement for UNC-83 in nuclear migration. Yeast two-hybrid, in vitro binding assay, heterologous tissue culture recruitment assay, genetic epistasis with mutant phenotype analysis, synthetic rescue experiment Development (Cambridge, England) High 19605495
2004 In C. elegans, UNC-116/KHC and KLC-2 form a complex orthologous to kinesin-1. KLC-2 also binds UNC-16 (JIP3/JSAP1 orthologue) and the UNC-14 RUN domain protein. Localization of UNC-16 and UNC-14 depends on kinesin-1 (UNC-116 and KLC-2). Double mutant analysis places unc-116, klc-2, unc-16, and unc-14 in the same pathway controlling synaptic vesicle component localization. Co-immunoprecipitation, genetic epistasis (double-mutant analysis), fluorescent marker localization in mutant backgrounds Molecular biology of the cell High 15563606
2015 Rab1A on melanosomes recruits SKIP/PLEKHM2 as a Rab1A-specific effector, and Rab1A, SKIP, and a kinesin-1/(KIF5b+KLC2) motor form a transport complex that mediates anterograde melanosome transport in melanocytes. Co-immunoprecipitation, knockdown with transport phenotype readout, fluorescence microscopy of melanosome movement Scientific reports Medium 25649263
2017 Crystal structures of both KLC1 and KLC2 TPR domains including the N-terminal capping helix show that this helix adopts two distinct orientations relative to the TPR domain, generating a hydrophobic pocket and electrostatic variations at the groove surface. Ligand binding in the groove can be specific to one or the other N-terminal capping helix orientation, and the capping helix may serve as a protein-protein interaction site. X-ray crystallography, structural comparative analysis PloS one Medium 29036226
2021 KLC2 is required for transport of NIS (sodium/iodide symporter) beyond the endoplasmic reticulum to the plasma membrane via a tryptophan-acidic (W-acidic) motif adjacent to G561 in NIS. A G561E NIS variant impairs recognition of this motif by KLC2. Knockdown of Klc2 in rat thyroid cells causes defective NIS maturation and decreased iodide accumulation; morpholino knockdown of klc2 in zebrafish causes hypothyroidism. Siever sequencing, iodide uptake assays, biochemical interaction assays, siRNA knockdown in thyroid cells, morpholino knockdown in zebrafish, structural bioinformatic analysis The Journal of clinical endocrinology and metabolism Medium 33912899
2021 KLC2 deficiency in mice causes abnormal mitochondrial transport and downregulation of the GABAA receptor family in cochlear hair cells, leading to low-frequency sensorineural hearing loss. AAV-mediated delivery of wild-type Klc2 cDNA rescued hearing thresholds and reduced outer hair cell loss in Klc2-null mice. Klc2 knockout mouse model, ABR threshold measurement, immunostaining, AAV gene rescue Molecular neurobiology Medium 34014435
2019 KLC2 interacts with Nup358 through a W-acidic motif in Nup358 that is highly conserved among vertebrates. KLC2 and Nup358 form predominantly monomers alone, but their interaction produces 2:2 complexes. The dynein adaptor BicD2 and KLC2 interact simultaneously with Nup358, forming 2:2:2 complexes, suggesting simultaneous recruitment of kinesin-1 and dynein to the nuclear pore. In vitro reconstitution, biochemical binding assays, analytical ultracentrifugation or similar biophysical characterization Biochemistry High 31756096
2025 In C. elegans, UNC-83c isoform binds KLC-2 with high affinity to promote kinesin-1 activation for plus-end nuclear movement, while UNC-83a/b isoforms contain an N-terminal inhibitory domain that directly binds kinesin heavy chain UNC-116, reducing its affinity for KLC-2 and allowing dynein-mediated transport. AlphaFold predictions identify spectrin-like repeats in the inhibitory domain, genetically confirmed to be essential for dynein-dependent P cell migration. Genetic epistasis (C. elegans mutant analysis), in vitro binding assays, AlphaFold structural prediction with genetic validation, isoform-specific functional analysis Current biology : CB Medium 40925371
2018 Silencing of KLC1 and KLC2 in neurons inhibited the majority of anterograde HSV enveloped virion transport in axons, while kinesin-1 heavy chain proteins KIF5A, -5B, and -5C also colocalized with HSV particles and were required for transport. Kinesin-3 (KIF1A) silencing had little effect. siRNA silencing, fluorescence colocalization, live imaging of anterograde transport in neuronal axons Journal of virology Medium 30068641
2008 UPEC type 1 pilus-mediated invasion of bladder cells requires kinesin-1 light chain KLC2, as well as HDAC6 and microtubules. Silencing KLC2 inhibited host cell invasion by UPEC. siRNA silencing of KLC2 with invasion assay readout The Journal of biological chemistry Low 18996840
2015 A homozygous 216-bp deletion in the non-coding upstream region of KLC2 causes SPOAN syndrome by increasing KLC2 expression 48–74% above wild-type levels, as confirmed by luciferase reporter assays in constructs bearing the deletion. Both knockdown and overexpression of klc2 in zebrafish produced a curly-tail phenotype suggestive of neuromuscular disorder. Whole-genome sequencing, luciferase reporter assay, klc2 knockdown and overexpression in zebrafish, expression analysis in patient fibroblasts and iPSC-derived motor neurons Human molecular genetics Medium 26385635
2005 In C. elegans, UNC-33 (CRMP orthologue) interacts with UNC-14 and KLC-2 in vivo, and its localization to neurites requires UNC-116 (kinesin heavy chain) and KLC-2. Mutations in unc-116 and klc-2 mislocalize UNC-33 to the cell body, implicating kinesin-1 (UNC-116/KLC-2 complex) in axonal transport of UNC-33 for neurite outgrowth. Co-immunoprecipitation in vivo (C. elegans), mutant localization analysis, genetic screening Journal of neurochemistry Medium 16236031
2025 Structural characterization by cryo-EM and SAXS of a minimal KLC2/Nup358/BicD2 complex reveals a rod-like KLC2/Nup358 structure. Addition of BicD2 increases the complex thickness and shifts stoichiometry toward 2:2:2, suggesting cooperative recruitment of kinesin-1 and dynein to Nup358 modulated by oligomeric state. Cryo-electron microscopy, small angle X-ray scattering (SAXS), reconstituted minimal complex bioRxiv : the preprint server for biologypreprint Medium 41648486
2025 In C. elegans, reduced-function mutation in klc-2 alters the superdiffusive retrograde movement of dense core vesicles (DCVs) in ALA neurons, demonstrating that KLC-2 (kinesin-1 light chain) influences DCV transport dynamics even in the retrograde direction. Live imaging of DCV trajectories in C. elegans neurons, mathematical modelling of transport statistics across three genetic strains Scientific reports Low 40016327
2025 KLC2 mutants identified in CML myeloid blast phase patients promote cell proliferation, decrease imatinib sensitivity, and impair TGF-β-mediated SMAD2/3 activation while enhancing STAT3 phosphorylation. Both wild-type and mutant KLC2 interact with SMAD2, but mutant KLC2 disrupts TGF-β/SMAD2 signaling. Immunoprecipitation (KLC2-SMAD2 interaction), immunoblot for STAT3/SMAD2/3 phosphorylation, cell proliferation/apoptosis assays, xenograft mouse model Oncology research Medium 41502514

Source papers

Stage 0 corpus · 43 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2004 The Caenorhabditis elegans UNC-14 RUN domain protein binds to the kinesin-1 and UNC-16 complex and regulates synaptic vesicle localization. Molecular biology of the cell 105 15563606
2010 A kinesin signaling complex mediates the ability of GSK-3beta to affect mood-associated behaviors. Proceedings of the National Academy of Sciences of the United States of America 104 20534517
1999 Defective kinesin heavy chain behavior in mouse kinesin light chain mutants. The Journal of cell biology 89 10491391
2009 UNC-83 is a nuclear-specific cargo adaptor for kinesin-1-mediated nuclear migration. Development (Cambridge, England) 88 19605495
2011 A kinesin-1 binding motif in vaccinia virus that is widespread throughout the human genome. The EMBO journal 81 21915095
2008 Conventional kinesin holoenzymes are composed of heavy and light chain homodimers. Biochemistry 68 18361505
2001 Kinesin light-chain KLC3 expression in testis is restricted to spermatids. Biology of reproduction 54 11319135
2011 Lemur tyrosine kinase-2 signalling regulates kinesin-1 light chain-2 phosphorylation and binding of Smad2 cargo. Oncogene 46 21996745
2002 Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein. Biochemistry 46 11969417
2005 Regulatory machinery of UNC-33 Ce-CRMP localization in neurites during neuronal development in Caenorhabditis elegans. Journal of neurochemistry 44 16236031
2012 Identification of early zygotic genes in the yellow fever mosquito Aedes aegypti and discovery of a motif involved in early zygotic genome activation. PloS one 43 22457801
2021 Deficiency of Klc2 Induces Low-Frequency Sensorineural Hearing Loss in C57BL/6 J Mice and Human. Molecular neurobiology 42 34014435
2015 Rab1A regulates anterograde melanosome transport by recruiting kinesin-1 to melanosomes through interaction with SKIP. Scientific reports 42 25649263
2010 Vaccinia protein F12 has structural similarity to kinesin light chain and contains a motor binding motif required for virion export. PLoS pathogens 40 20195521
2015 Overexpression of KLC2 due to a homozygous deletion in the non-coding region causes SPOAN syndrome. Human molecular genetics 39 26385635
2008 Uropathogenic Escherichia coli invades host cells via an HDAC6-modulated microtubule-dependent pathway. The Journal of biological chemistry 39 18996840
2012 Crystal structures of the tetratricopeptide repeat domains of kinesin light chains: insight into cargo recognition mechanisms. PloS one 37 22470497
2018 Kinesin-1 Proteins KIF5A, -5B, and -5C Promote Anterograde Transport of Herpes Simplex Virus Enveloped Virions in Axons. Journal of virology 36 30068641
1985 Steady-state kinetics of skeletal muscle myosin light chain kinase indicate a strong down regulation by products. European journal of biochemistry 24 3841060
2015 High expression of kinesin light chain-2, a novel target of miR-125b, is associated with poor clinical outcome of elderly non-small-cell lung cancer patients. British journal of cancer 20 25668010
2021 A Novel SLC5A5 Variant Reveals the Crucial Role of Kinesin Light Chain 2 in Thyroid Hormonogenesis. The Journal of clinical endocrinology and metabolism 18 33912899
2019 Adapter Proteins for Opposing Motors Interact Simultaneously with Nuclear Pore Protein Nup358. Biochemistry 16 31756096
2015 Interactome analysis reveals that FAM161A, deficient in recessive retinitis pigmentosa, is a component of the Golgi-centrosomal network. Human molecular genetics 16 25749990
2020 GSK-3β regulates the synaptic expression of NMDA receptors via phosphorylation of phosphatidylinositol 4 kinase type IIα. The European journal of neuroscience 15 32463939
2008 Insulin-induced GLUT4 movements in C2C12 myoblasts: evidence against a role of conventional kinesin motor proteins. The Kobe journal of medical sciences 11 18772605
2017 Structural plasticity of the N-terminal capping helix of the TPR domain of kinesin light chain. PloS one 10 29036226
2022 The role and possible mechanism of the long noncoding RNA LINC01260 in nonalcoholic fatty liver disease. Nutrition & metabolism 8 35016686
2022 Dopey proteins are essential but overlooked regulators of membrane trafficking. Journal of cell science 8 35388894
2022 LINC00152 Drives a Competing Endogenous RNA Network in Human Hepatocellular Carcinoma. Cells 8 35563834
2022 Brain Epitranscriptomic Analysis Revealed Altered A-to-I RNA Editing in Septic Patients. Frontiers in genetics 7 35559016
2023 The kinesin light chain-2, a target of mRNA stabilizing protein HuR, inhibits p53 protein phosphorylation to promote radioresistance in NSCLC. Thoracic cancer 6 37055376
2023 Identification of HSPA8 as an interacting partner of MAB21L2 and an important factor in eye development. Developmental dynamics : an official publication of the American Association of Anatomists 5 36576422
2023 A humanized Caenorhabditis elegans model of hereditary spastic paraplegia-associated variants in KLC4. Disease models & mechanisms 5 37565267
2018 Functional analysis of the promoter of an early zygotic gene KLC2 in Aedes aegypti. Parasites & vectors 5 30583735
2018 Origin and age of the causative mutations in KLC2, IMPA1, MED25 and WNT7A unravelled through Brazilian admixed populations. Scientific reports 4 30410084
2024 Tail-anchored membrane protein SLMAP3 is essential for targeting centrosomal proteins to the nuclear envelope in skeletal myogenesis. Open biology 3 39378988
2025 The KASH protein UNC-83 differentially regulates kinesin-1 activity to control developmental stage-specific nuclear migration. Current biology : CB 2 40925371
2025 The KASH protein UNC-83 differentially regulates kinesin-1 activity to control developmental stage-specific nuclear migration. bioRxiv : the preprint server for biology 1 40093101
2023 A humanized Caenorhabditis elegans model of Hereditary Spastic Paraplegia-associated variants in kinesin light chain KLC4. bioRxiv : the preprint server for biology 1 36789438
2026 Structural characterization of a minimal KLC2/Nup358/BicD2 complex. bioRxiv : the preprint server for biology 0 41648486
2026 FOXK1 induced upregulation of KIF20A promotes hepatocellular carcinoma progression via Wnt/β-Catenin/EMT signaling. Cellular and molecular life sciences : CMLS 0 41714472
2025 Heterogeneous model for superdiffusive movement of dense core vesicles in C. elegans. Scientific reports 0 40016327
2025 Biological Features of KLC2 Mutations in Chronic Myeloid Leukemia and Their Contribution to Inducing Drug Resistance. Oncology research 0 41502514

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