ARL6IP6

ARL6IP6 is a transmembrane protein concentrated at the nuclear envelope, likely residing in the inner nuclear membrane, as established by organellar proteomics enrichment scoring and quantitative immunofluorescence across mesenchymal stem cells, adipocytes, and myocytes (PMID:31142202). Beyond this localization, no molecular function, binding partner, or pathway role for ARL6IP6 has been characterized in the available corpus.

1. 2019 Medium

   Where ARL6IP6 resides in the cell was unknown; combining subcellular fractionation with quantitative imaging placed the protein at the nuclear envelope, most likely the inner nuclear membrane, defining the compartment in which it must act.

   Evidence Organellar proteomics enrichment scoring plus quantitative immunofluorescence microscopy in mesenchymal stem cells, adipocytes, and myocytes

   PMID:31142202

   Open questions at the time

   • Membrane topology and orientation within the inner nuclear membrane not resolved
   • No binding partners or interacting complexes identified
   • No molecular activity or pathway role established

• The molecular function of ARL6IP6 at the nuclear envelope remains undefined.
• No biochemical activity assigned
• No genetic or interaction data linking ARL6IP6 to a defined pathway
• Functional consequence of localization to the inner nuclear membrane unknown