Affinage

KIF1B

Kinesin-like protein KIF1B · UniProt O60333

Length
1816 aa
Mass
204.5 kDa
Annotated
2026-06-10
100 papers in source corpus 11 papers cited in narrative 12 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

KIF1B is a monomeric, microtubule plus-end-directed kinesin-3 motor that drives anterograde axonal transport and is required in vivo for the outgrowth of the longest peripheral and central axons (PMID:7528108, PMID:19503091). The originally characterized isoform colocalizes with and transports mitochondria along microtubules in vitro (PMID:7528108), while alternative splicing of the gene generates distinct isoforms—including a longer brain-enriched variant bearing a novel KIF1A-homologous C-terminal cargo-binding domain and a major isoform lacking the mitochondria-binding domain—that confer distinct cargo specificities (PMID:10571041, PMID:10341097). Motor output is tuned at the mechanochemical level: splice variants differing in K-loop and hinge insertions display higher microtubule-dependent ATPase activity and microtubule affinity, with the K-loop directly modulating these properties (PMID:19744141). As a transport motor, KIF1B together with its binding partner KBP delivers the microtubule regulator SCG10/Stathmin-2 to axon growth cones to control microtubule stability and axon elongation, a function genetically separable from mitochondrial transport in vivo (PMID:27358458), and it is also required for localization of myelin basic protein mRNA to oligodendrocyte processes (PMID:19503091). Beyond neural transport, KIF1B mediates cell-surface delivery of the matrix metalloproteinase MT1-MMP to promote tumor cell migration and invasion (PMID:23354307, PMID:26576027), regulates spindle dynamics, chromosome congression, and mitochondrial distribution during oocyte meiosis (PMID:27696585), and acts upstream of NLRP3 inflammasome–driven pyroptosis in airway inflammation (PMID:41384344).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 1994 High

    Established KIF1B as a bona fide motor protein with intrinsic cargo-transport capacity, answering whether it could physically move organelles along microtubules.

    Evidence Rotary-shadowing EM, subcellular fractionation, and in vitro microtubule-based transport reconstitution showing monomeric KIF1B transporting mitochondria

    PMID:7528108

    Open questions at the time
    • Mechanism of cargo (mitochondria) attachment not defined
    • Regulation of motor activity in cells not addressed
    • Did not anticipate isoform diversity
  2. 1999 Medium

    Revealed that the Kif1b locus produces multiple isoforms by alternative splicing with divergent C-terminal cargo-binding domains, reframing KIF1B as a family of motors with potentially distinct cargoes rather than a single mitochondrial transporter.

    Evidence cDNA cloning, Northern blot across tissues, and C-terminal domain sequence comparison identifying KIF1Bα, KIF1Bβ, and a brain isoform lacking the mitochondria-binding domain

    PMID:10341097 PMID:10571041

    Open questions at the time
    • Distinct cargo specificities inferred from sequence, not tested in transport assays
    • Tissue-specific functions of each isoform unresolved
  3. 2009 High

    Connected splice-variant sequence differences to motor mechanochemistry, showing the K-loop directly tunes microtubule binding and ATPase output.

    Evidence Recombinant protein microtubule-dependent ATPase and motility assays with K-loop insertion mutagenesis

    PMID:19744141

    Open questions at the time
    • Physiological consequence of differential ATPase tuning in vivo not established
    • Does not link mechanochemical state to specific cargo selection
  4. 2009 High

    Defined an in vivo neural requirement for KIF1B in long-axon outgrowth and in mRNA localization for myelination, extending its role beyond organelle transport to cargo delivery underpinning neural development.

    Evidence Zebrafish kif1b loss-of-function mutants with in vivo imaging of axon growth and mbp mRNA localization

    PMID:19503091

    Open questions at the time
    • Molecular cargo delivered to support axon outgrowth not yet identified at this stage
    • Mechanism of mRNA cargo coupling unknown
  5. 2016 High

    Identified SCG10/Stathmin-2 as a functional KIF1B cargo delivered via the partner KBP, mechanistically explaining the axon-outgrowth phenotype and dissociating it from mitochondrial transport.

    Evidence Zebrafish kbp mutants, live imaging of SCG10 and microtubule dynamics, SCG10-overexpression rescue, and explicit mitochondrial transport controls

    PMID:27358458

    Open questions at the time
    • Direct biochemical KIF1B–KBP–SCG10 cargo complex not reconstituted
    • Relationship between KBP-dependent and mitochondrial transport functions not fully reconciled
  6. 2016 Medium

    Extended KIF1B function to cell division, showing it governs meiotic spindle dynamics, chromosome congression, and mitochondrial distribution in oocytes.

    Evidence siRNA depletion in mouse oocytes with immunofluorescence of spindle/chromosomes, mitochondrial distribution, and ATP quantification

    PMID:27696585

    Open questions at the time
    • Direct molecular targets at the spindle not identified
    • Single lab; isoform responsible not specified
    • Whether spindle defect is secondary to mitochondrial/ATP disruption unclear
  7. 2013 Medium

    Implicated KIF1B in cancer cell invasion through transport-dependent surface delivery of MT1-MMP, generalizing its transport role to disease-relevant cargo.

    Evidence Co-IP, siRNA knockdown, cell-surface biotinylation, and transwell invasion assays in leptin-stimulated gastric cancer cells

    PMID:23354307

    Open questions at the time
    • Direct vs indirect KIF1B–MT1-MMP interaction not fully resolved
    • Single lab at time of report
  8. 2015 Medium

    Corroborated KIF1B-dependent MT1-MMP surface localization as a pro-invasive mechanism in a second tumor type, strengthening the transport interpretation.

    Evidence siRNA knockdown with surface vs total MT1-MMP measurement and migration/invasion assays in glioma cells

    PMID:26576027

    Open questions at the time
    • Single primary method (knockdown)
    • Mechanism of MT1-MMP cargo coupling unresolved
  9. 2024 Medium

    Positioned KIF1B downstream of TRIM14 in an inflammatory signaling axis driving renal tubular injury, indicating regulated KIF1B expression in disease.

    Evidence Co-IP, immunofluorescence co-localization, TRIM14 knockdown/overexpression with TLR4/NF-κB readouts in a rat diabetic nephropathy model

    PMID:41710718

    Open questions at the time
    • Whether KIF1B motor/transport activity is required for the phenotype not tested
    • Single lab
  10. 2025 Medium

    Placed KIF1B upstream of NLRP3 inflammasome activation and pyroptosis in airway inflammation, expanding its role into innate immune signaling.

    Evidence siRNA knockdown with NLRP3-overexpression rescue and pyroptosis marker Western blots in IL-13-stimulated epithelial cells and an OVA mouse asthma model

    PMID:41384344

    Open questions at the time
    • Mechanistic link between a microtubule motor and NLRP3 activation undefined
    • Single lab; direct interactors in this pathway not identified

Open questions

Synthesis pass · forward-looking unresolved questions
  • How distinct KIF1B splice isoforms select and couple their respective cargoes (mitochondria, synaptic vesicle precursors, SCG10/KBP, MT1-MMP, mRNAs) at the molecular level, and how the motor connects to inflammasome and spindle functions, remain unresolved.
  • No reconstituted isoform-specific cargo-adaptor complexes
  • Mechanistic basis for non-transport roles (NLRP3, spindle) unestablished
  • Isoform-resolved functional assignment across tissues incomplete

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003774 cytoskeletal motor activity 2 GO:0008092 cytoskeletal protein binding 2 GO:0140657 ATP-dependent activity 2
Localization
GO:0005886 plasma membrane 2 GO:0005739 mitochondrion 1 GO:0005856 cytoskeleton 1
Pathway
R-HSA-5653656 Vesicle-mediated transport 2 R-HSA-9609507 Protein localization 2
Partners
KBPMT1-MMPSCG10TRIM14

Evidence

Reading pass · 12 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1994 KIF1B is a monomeric, microtubule plus end-directed motor protein that colocalizes with mitochondria in vivo, is concentrated in the mitochondrial subcellular fraction, and can transport mitochondria along microtubules in vitro. Rotary shadowing electron microscopy (monomeric structure), immunocytochemistry (colocalization with mitochondria), subcellular fractionation, in vitro microtubule-based transport assay Cell High 7528108
1999 The Kif1b gene generates at least two major kinesin isoforms by alternative splicing: a shorter KIF1Bα (130 kDa) and a longer KIF1Bβ (204 kDa) with a novel C-terminal cargo-binding domain homologous to KIF1A, suggesting distinct cargo specificities. cDNA cloning, Northern blot analysis, haplotype mapping, alternative exon identification Gene Medium 10571041
1999 The major brain isoform of Kif1b lacks the putative mitochondria-binding domain present in the originally described isoform, indicating that alternative splicing produces an isoform likely to have different cargo-binding specificity. cDNA library screening, Northern blot analysis, sequence comparison of C-terminal domains Mammalian genome Medium 10341097
2009 Alternative splicing of KIF1B produces variants that differ in insertion sequences within the K-loop and hinge regions; variants containing both insertions show higher microtubule-dependent ATPase activity and microtubule affinity than those without insertions, as demonstrated by in vitro ATPase assays and mutational analysis of the K-loop. Recombinant protein expression, microtubule-dependent ATPase assay, in vitro motility assay, K-loop insertion mutagenesis Traffic High 19744141
2009 Kif1b is required for localization of myelin basic protein (mbp) mRNA to processes of myelinating oligodendrocytes in zebrafish; loss of kif1b causes ectopic appearance of myelin-like membrane and mislocalization of myelin proteins to oligodendrocyte cell bodies. Zebrafish kif1b mutant analysis, in vivo imaging, mRNA localization assays Nature genetics High 19503091
2009 Kif1b is required for outgrowth of some of the longest axons in both peripheral and central nervous systems in zebrafish, establishing a role for this motor in axon elongation in vivo. Zebrafish kif1b mutant analysis, in vivo imaging of axon growth Nature genetics High 19503091
2013 Leptin promotes gastric cancer cell invasion partly through KIF1B-dependent surface localization of MT1-MMP; co-immunoprecipitation showed leptin enhances the KIF1B–MT1-MMP interaction in a time-dependent manner, and siRNA knockdown of KIF1B inhibits leptin-induced membrane targeting of MT1-MMP. Co-immunoprecipitation, siRNA knockdown, cell surface biotinylation assay, flow cytometry, transwell invasion assay Carcinogenesis Medium 23354307
2015 KIF1B promotes glioma cell migration and invasion through cell surface localization of MT1-MMP; siRNA knockdown of KIF1B reduces membranous MT1-MMP levels without altering total cellular MT1-MMP, consistent with a transport function. siRNA knockdown, transwell migration/invasion assay, cell surface MT1-MMP measurement Oncology reports Medium 26576027
2016 The Kif1B motor and its binding partner KBP are required for anterograde transport of SCG10 (Stathmin-2) to axon growth cones in zebrafish; loss of KBP reduces SCG10 at growth cones, alters microtubule stability, and truncates axons—phenotypes rescued by SCG10 overexpression. Loss of Kif1B or KBP did not inhibit mitochondrial transport in this in vivo context. Zebrafish mutant analysis (kbp mutants), in vivo live imaging of SCG10 and microtubule dynamics, genetic epistasis (SCG10 overexpression rescue), mitochondrial transport imaging The Journal of neuroscience High 27358458
2016 KIF1B loss-of-function in mouse oocytes causes abnormal polar body extrusion, disordered spindle dynamics, chromosome congression defects, increased aneuploidy, and impaired embryonic development; KIF1B depletion also disrupts mitochondrial distribution and reduces ATP abundance in oocytes. siRNA-mediated KIF1B depletion, immunofluorescence for spindle assembly and chromosome alignment, mitochondrial distribution assay, ATP quantification Molecular reproduction and development Medium 27696585
2025 KIF1B promotes NLRP3 inflammasome-mediated pyroptosis in asthma; KIF1B knockdown reduces expression of NLRP3, cleaved caspase-1, and cleaved GSDMD, and NLRP3 overexpression abolishes these protective effects, placing KIF1B upstream of NLRP3 in airway inflammatory signaling. siRNA knockdown, NLRP3 overexpression rescue, in vitro IL-13-stimulated airway epithelial cells, OVA-induced mouse asthma model, Western blot for pyroptosis markers Journal of cellular and molecular medicine Medium 41384344
2024 TRIM14 directly interacts with KIF1B (confirmed by co-immunoprecipitation and immunofluorescence co-localization) and positively regulates KIF1B expression; this TRIM14–KIF1B axis drives renal tubular injury in diabetic nephropathy via TLR4/NF-κB pathway activation. Co-immunoprecipitation, immunofluorescence, siRNA knockdown of TRIM14, TRIM14 overexpression, Western blot, in vivo rat DN model, protein-protein interaction network analysis Diabetes, metabolic syndrome and obesity Medium 41710718

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1994 KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondria. Cell 496 7528108
2007 Complementation between mouse Mfn1 and Mfn2 protects mitochondrial fusion defects caused by CMT2A disease mutations. The Journal of cell biology 285 17296794
2011 MFN2 mutations cause severe phenotypes in most patients with CMT2A. Neurology 177 21508331
2019 Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset. Nature communications 144 31664033
2005 Clinical and electrophysiologic features of CMT2A with mutations in the mitofusin 2 gene. Neurology 139 16043786
1993 Localization of a gene (CMT2A) for autosomal dominant Charcot-Marie-Tooth disease type 2 to chromosome 1p and evidence of genetic heterogeneity. Genomics 139 8406488
2008 Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis. Nature genetics 136 18997785
2009 Kif1b is essential for mRNA localization in oligodendrocytes and development of myelinated axons. Nature genetics 134 19503091
2008 A germline mutation of the KIF1B beta gene on 1p36 in a family with neural and nonneural tumors. Human genetics 123 18726616
2005 The KLP-6 kinesin is required for male mating behaviors and polycystin localization in Caenorhabditis elegans. Current biology : CB 105 15753033
2003 Localization of Pavarotti-KLP in living Drosophila embryos suggests roles in reorganizing the cortical cytoskeleton during the mitotic cycle. Molecular biology of the cell 68 14517316
2018 Mitofusin gain and loss of function drive pathogenesis in Drosophila models of CMT2A neuropathy. EMBO reports 67 29898954
2011 Kinesin-3 KLP-6 regulates intraflagellar transport in male-specific cilia of Caenorhabditis elegans. Current biology : CB 59 21757353
2003 KLP-18, a Klp2 kinesin, is required for assembly of acentrosomal meiotic spindles in Caenorhabditis elegans. Molecular biology of the cell 54 12937278
2020 HDAC6 inhibition promotes α-tubulin acetylation and ameliorates CMT2A peripheral neuropathy in mice. Experimental neurology 53 32147437
2004 Loss of KLP-19 polar ejection force causes misorientation and missegregation of holocentric chromosomes. The Journal of cell biology 53 15452142
2020 Burst mitofusin activation reverses neuromuscular dysfunction in murine CMT2A. eLife 47 33074106
2016 Assembly of Caenorhabditis elegans acentrosomal spindles occurs without evident microtubule-organizing centers and requires microtubule sorting by KLP-18/kinesin-12 and MESP-1. Molecular biology of the cell 46 27559133
2013 Leptin-mediated regulation of MT1-MMP localization is KIF1B dependent and enhances gastric cancer cell invasion. Carcinogenesis 43 23354307
2015 KLP-7 acts through the Ndc80 complex to limit pole number in C. elegans oocyte meiotic spindle assembly. The Journal of cell biology 42 26370499
2017 Inhibition of ectopic microtubule assembly by the kinesin-13 KLP-7 prevents chromosome segregation and cytokinesis defects in oocytes. Development (Cambridge, England) 41 28289130
1997 Linkage mapping of the gene for Charcot-Marie-Tooth disease type 2 to chromosome 1p (CMT2A) and the clinical features of CMT2A. Neurology 38 9409358
2009 A mutation associated with CMT2A neuropathy causes defects in Fzo1 GTP hydrolysis, ubiquitylation, and protein turnover. Molecular biology of the cell 34 19812251
2013 The KIF1B (rs17401966) single nucleotide polymorphism is not associated with the development of HBV-related hepatocellular carcinoma in Thai patients. Asian Pacific journal of cancer prevention : APJCP 32 23803045
1997 Pax-5 is identical to EBB-1/KLP and binds to the VpreB and lambda5 promoters as well as the KI and KII sites upstream of the Jkappa genes. European journal of immunology 32 9079818
2015 The KLP-7 Residue S546 Is a Putative Aurora Kinase Site Required for Microtubule Regulation at the Centrosome in C. elegans. PloS one 31 26168236
1998 Immunostimulatory effects of dimerized lysozyme (KLP-602) on the nonspecific defense mechanisms and protection against furunculosis in salmonids. Veterinary immunology and immunopathology 31 9613448
2015 KIF1B promotes glioma migration and invasion via cell surface localization of MT1-MMP. Oncology reports 30 26576027
1999 A novel mouse kinesin of the UNC-104/KIF1 subfamily encoded by the Kif1b gene. Gene 30 10571041
2012 The kinesin-3 family motor KLP-4 regulates anterograde trafficking of GLR-1 glutamate receptors in the ventral nerve cord of Caenorhabditis elegans. Molecular biology of the cell 29 22855524
2001 Genomic structure and mutational analysis of the human KIF1B gene which is homozygously deleted in neuroblastoma at chromosome 1p36.2. Oncogene 29 11526494
1996 mRNA expression of KIF1A, KIF1B, KIF2, KIF3A, KIF3B, KIF4, KIF5, and cytoplasmic dynein during axonal regeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience 28 8613797
1999 The major brain isoform of kif1b lacks the putative mitochondria-binding domain. Mammalian genome : official journal of the International Mammalian Genome Society 27 10341097
2007 Mitofusin 2 gene mutation (R94Q) causing severe early-onset axonal polyneuropathy (CMT2A). European journal of neurology 26 17437620
2016 Kif1B Interacts with KBP to Promote Axon Elongation by Localizing a Microtubule Regulator to Growth Cones. The Journal of neuroscience : the official journal of the Society for Neuroscience 25 27358458
2012 HBV-related hepatocellular carcinoma susceptibility gene KIF1B is not associated with development of chronic hepatitis B. PloS one 25 22363396
2013 Homozygous truncating mutation of the KBP gene, encoding a KIF1B-binding protein, in a familial case of fetal polymicrogyria. Neurogenetics 24 24072599
2022 MITOL-mediated DRP1 ubiquitylation and degradation promotes mitochondrial hyperfusion in a CMT2A-linked MFN2 mutant. Journal of cell science 23 34870686
2012 Role of single nucleotide polymorphisms of KIF1B gene in HBV-associated viral hepatitis. PloS one 21 23028799
2019 Disease Modeling and Therapeutic Strategies in CMT2A: State of the Art. Molecular neurobiology 20 30830587
2022 Circ_0003611 regulates apoptosis and oxidative stress injury of Alzheimer's disease via miR-383-5p/KIF1B axis. Metabolic brain disease 19 35960460
2013 Genetic polymorphism of the kinesin-like protein KIF1B gene and the risk of hepatocellular carcinoma. PloS one 19 23634229
2024 MFN2 coordinates mitochondria motility with α-tubulin acetylation and this regulation is disrupted in CMT2A. iScience 17 38883841
2016 Loss of function of KIF1B impairs oocyte meiotic maturation and early embryonic development in mice. Molecular reproduction and development 17 27696585
2009 Altered motor activity of alternative splice variants of the mammalian kinesin-3 protein KIF1B. Traffic (Copenhagen, Denmark) 17 19744141
1992 Characterization of a new kallikrein-like enzyme (KLP-S3) of the rat submandibular gland. The Biochemical journal 17 1536657
2022 Structural model of microtubule dynamics inhibition by kinesin-4 from the crystal structure of KLP-12 -tubulin complex. eLife 16 36065637
2012 Behavioral and molecular exploration of the AR-CMT2A mouse model Lmna (R298C/R298C). Neuromolecular medicine 16 22331516
2022 CMT2A-linked mitochondrial hyperfusion-driving mutant MFN2 perturbs ER-mitochondrial associations and Ca2+ homeostasis. Biology of the cell 15 35924634
2022 Mitochondria Clumping vs. Mitochondria Fusion in CMT2A Diseases. Life (Basel, Switzerland) 15 36556475
2020 Defective nucleotide-dependent assembly and membrane fusion in Mfn2 CMT2A variants improved by Bax. Life science alliance 15 32245838
2000 Identification of the full-length KIAA0591 gene encoding a novel kinesin-related protein which is mapped to the neuroblastoma suppressor gene locus at 1p36.2. International journal of oncology 15 10762626
2016 Effects of interactions between environmental factors and KIF1B genetic variants on the risk of hepatocellular carcinoma in a Chinese cohort. World journal of gastroenterology 14 27122668
2005 Stretchin-klp, a novel Drosophila indirect flight muscle protein, has both myosin dependent and independent isoforms. Journal of muscle research and cell motility 14 16270160
2021 Aberrant Mitochondrial Dynamics and Exacerbated Response to Neuroinflammation in a Novel Mouse Model of CMT2A. International journal of molecular sciences 13 34769001
2006 Dynactin targets Pavarotti-KLP to the central spindle during anaphase and facilitates cytokinesis in Drosophila S2 cells. Journal of cell science 13 17046997
1997 Molecular cloning and expression of the Caenorhabditis elegans klp-3, an ortholog of C terminus motor kinesins Kar3 and ncd. Journal of molecular biology 13 9245592
2022 Circ_0049472 regulates the damage of Aβ-induced SK-N-SH and CHP-212 cells by mediating the miR-107/KIF1B axis. Experimental brain research 12 35881155
2020 CMT2A Harboring Mitofusin 2 Mutation with Optic Nerve Atrophy and Normal Visual Acuity. International medical case reports journal 12 32110117
2010 Lack of replication of KIF1B gene in an Italian primary progressive multiple sclerosis cohort. European journal of neurology 12 20067515
2005 Mutational study of the 1p located genes p18ink4c, Patched-2, RIZ1 and KIF1B in oligodendrogliomas. Oncology reports 11 15711769
2021 CircPOSTN competes with KIF1B for miR-185-5p binding sites to promote the tumorigenesis of glioma. Brain research bulletin 10 34974134
2017 A Botrytis cinerea KLP-7 Kinesin acts as a Virulence Determinant during Plant Infection. Scientific reports 10 28878341
2016 Increased mitochondrial fusion in a autosomal recessive CMT2A family with mitochondrial GTPase mitofusin 2 mutations. Journal of the peripheral nervous system : JPNS 10 27706887
2021 Loose Plant Architecture 1-Interacting Kinesin-like Protein KLP Promotes Rice Resistance to Sheath Blight Disease. Rice (New York, N.Y.) 9 34215911
2020 Genetic predisposition to neural crest-derived tumors: revisiting the role of KIF1B. Endocrine connections 9 33112832
2013 Mitofusin 2 gene mutation causing early-onset CMT2A with different progressive courses. Clinical neuropathology 9 22762946
2004 Absence of KIF1B mutation in a large Turkish CMT2A family suggests involvement of a second gene. Neurology 9 15136675
1999 Effects of dimerized lysozyme (KLP-602) on the cellular and humoral defence mechanisms in sheatfish (Silurus glanis): in vitro and in vivo study. Veterinary research 9 10478423
2024 Comparative analysis of two Caenorhabditis elegans kinesins KLP-6 and UNC-104 reveals a common and distinct activation mechanism in kinesin-3. eLife 8 38206323
2022 Structure and biological evaluation of Caenorhabditis elegans CISD-1/mitoNEET, a KLP-17 tail domain homologue, supports attenuation of paraquat-induced oxidative stress through a p38 MAPK-mediated antioxidant defense response. Advances in redox research 7 36533211
2020 Animal Models of CMT2A: State-of-art and Therapeutic Implications. Molecular neurobiology 7 32856204
2017 Mosaicism for a pathogenic MFN2 mutation causes minimal clinical features of CMT2A in the parent of a severely affected child. Neurogenetics 7 28063088
2005 Essential kinesins: characterization of Caenorhabditis elegans KLP-15. Biochemistry 7 15850386
2023 CMT2A-linked MFN2 mutation, T206I promotes mitochondrial hyperfusion and predisposes cells towards mitophagy. Mitochondrion 6 38092249
2022 A case of juvenile-onset pheochromocytoma with KIF1B p.V1529M germline mutation. Endocrine journal 6 35046208
2019 The Kinesin-3 motor, KLP-4, mediates axonal organization and cholinergic signaling in Caenorhabditis elegans. FASEB bioAdvances 6 32123843
2000 C. elegans KLP-11/OSM-3/KAP-1: orthologs of the sea urchin kinesin-II, and mouse KIF3A/KIFB/KAP3 kinesin complexes. DNA research : an international journal for rapid publication of reports on genes and genomes 6 10819327
2018 A mutation in the heptad repeat 2 domain of MFN2 in a large CMT2A family. Journal of the peripheral nervous system : JPNS 5 29341354
2024 KLP-7/Kinesin-13 orchestrates axon-dendrite checkpoints for polarized trafficking in neurons. Molecular biology of the cell 4 38985513
2000 cDNA cloning and expression of a C-terminus motor kinesin-like protein KLP-17, involved in chromosomal movement in Caenorhabditis elegans. Biochemical and biophysical research communications 4 10631116
2025 An ultra-rare missense variant in the KIF1B gene linked to autoinflammatory Menière's disease. NPJ genomic medicine 3 40393993
2024 Chromokinesin Klp-19 regulates microtubule overlap and dynamics during anaphase in C. elegans. bioRxiv : the preprint server for biology 3 37961478
2022 tRNA-Derived Fragment tRF-18 Facilitates Cell Proliferation and Inhibits Cell Apoptosis via Modulating KIF1B in Papillary Thyroid Carcinoma. Critical reviews in eukaryotic gene expression 3 35993942
2015 [The relationship between the KIF1B (rs17401966) single nucleotide polymorphism and the genetic susceptibility to Hepatocellular carcinoma]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 3 26081705
2011 Polymorphic locus rs10492972 of the KIF1B gene association with multiple sclerosis in Russia: case control study. Molecular genetics and metabolism 3 21680216
2023 Case Report: A 65-year-old man with paraganglioma accompanied by elevated interleukin-6 levels and KIF1B single gene mutation. Frontiers in endocrinology 2 37780619
2019 Generation of induced pluripotent stem cell line, ZJUCHi002-A, from Charcot-Marie-Tooth disease type 2A (CMT2A) patient with a mutation of c.752C>T in MFN2. Stem cell research 2 30807887
2026 The TRIM14-KIF1B Axis Drives Renal Injury in Diabetic Nephropathy Through TLR4/NF-κB Pathway Modulation. Diabetes, metabolic syndrome and obesity : targets and therapy 1 41710718
2025 Modulating mitochondrial dynamics in CMT2A: a multifaceted platform for drug discovery and evaluation. Biophysics reports 1 40612231
2025 KIF1B Regulates NLRP3-Mediated Pyroptosis in Asthma Progression. Journal of cellular and molecular medicine 1 41384344
2024 CX‑5461 potentiates imatinib‑induced apoptosis in K562 cells by stimulating KIF1B expression. Experimental and therapeutic medicine 1 38356673
2024 Analysis of Expression of the GRIPAP1, DLG4, KIF1B, NGFRAP1, and NRF1 Genes in Peripheral Blood of the Patients with Parkinson's Disease in the Early Clinical Stages. Biochemistry. Biokhimiia 1 39523115
2023 Case Report: Aggressive neural crest tumors in a child with familial von Hippel Lindau syndrome associated with a germline VHL mutation (c.414A>G) and a novel KIF1B gene mutation. Frontiers in endocrinology 1 37564981
2019 Late onset CMT2A in a Family with an MFN2 Variant: c.2222T>G (p.Leu741Trp). Journal of neuromuscular diseases 1 31127728
2026 AAVrh74.tMCK.NT-3 Surrogate Gene Therapy in a Mouse Model of CMT2A. International journal of molecular sciences 0 41752078
2026 Exosomal circ0000549 promotes MNNG‑induced gastric cancer through miR‑15b‑5p/KIF1B. International journal of molecular medicine 0 41789656
2026 KLP-6 is a kinesin superfamily protein resistant to ADP inhibition. Communications biology 0 42086734
2025 Case Report: Rare multisystem metastasis in head and neck paraganglioma with SDHB pathogenic variant and KIF1B VUS manifested as FUO. Frontiers in endocrinology 0 40917352
2024 Biased movement of monomeric kinesin-3 KLP-6 explained by a symmetric Brownian ratchet model. Biophysical journal 0 39604259

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