Affinage

Showing KIFBP — KBP is a alias.

KIFBP

KIF-binding protein · UniProt Q96EK5

Length
621 aa
Mass
71.8 kDa
Annotated
2026-06-10
100 papers in source corpus 10 papers cited in narrative 10 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

KIFBP (KBP/KIF1BP/KIAA1279) is a tetratricopeptide repeat-containing adaptor that regulates kinesin motor function to control axonal microtubule dynamics and cargo transport during nervous system development (PMID:15883926, PMID:18192286). Its best-defined role is in neurons, where KBP couples the Kif1B motor to anterograde transport of the microtubule-destabilizing protein SCG10 (Stathmin-2): in zebrafish kbp mutants, SCG10 fails to reach growth cones, microtubule stability is altered, and axons truncate, a defect rescued by SCG10 overexpression and confirmed by an epistatic interaction between KBP and SCG10 (PMID:20621975, PMID:27358458). Consistent with a cytoskeletal mechanism, KBP loss disrupts axonal microtubules and slows axon outgrowth in vivo, while KBP itself does not bind microtubules directly but associates with the actin and tubulin cytoskeleton (PMID:18192286, PMID:23427148). KBP additionally functions in mitosis as an interaction partner of the kinesin Kif15, promoting its localization to the spindle equator and supporting chromosome alignment and stable kinetochore fiber assembly (PMID:28445502), and in mouse embryonic stem cells KBP is acetylated on Lys501 by GCN5L1 (using TDH-derived acetyl-CoA), marking it for Fbxo15-mediated proteasomal degradation that limits Kif1Bα-dependent mitochondrial biogenesis during pluripotency (PMID:28319092). In vivo, KIFBP is essential for enteric and central nervous system development, interacting with Ret to control vagal gut innervation (PMID:29192291), and homozygous loss-of-function mutations in humans cause Goldberg-Shprintzen syndrome with microcephaly, polymicrogyria, and Hirschsprung disease (PMID:15883926, PMID:24072599).

Mechanistic history

Synthesis pass · year-by-year structured walk · 9 steps
  1. 2005 Medium

    Establishing that KIAA1279 is a disease gene defined KBP's biological importance and revealed its TPR-domain architecture as a likely protein-interaction scaffold.

    Evidence homozygosity mapping and truncating mutation identification in Goldberg-Shprintzen syndrome patients

    PMID:15883926

    Open questions at the time
    • No molecular mechanism linking TPR domains to a specific motor or pathway
    • Causality from mutation to neuronal phenotype not experimentally dissected
  2. 2005 Medium

    Identifying KIF1Bα as a binding partner gave KBP its first molecular activity, framing it as a kinesin-3 motor regulator.

    Evidence yeast two-hybrid screen, reciprocal co-immunoprecipitation from HEK293 cells, immunofluorescence, and motility assays

    PMID:16225668

    Open questions at the time
    • Mitochondrial localization later contradicted by fibroblast studies
    • Whether KBP directly regulates motor processivity not resolved at biochemical level
  3. 2008 High

    In vivo loss-of-function moved KBP from an interactor to a developmental regulator, showing it is required for axon outgrowth via maintenance of axonal microtubules.

    Evidence zebrafish kbp mutant analysis with in vivo time-lapse imaging and electron microscopy

    PMID:18192286

    Open questions at the time
    • Did not identify the molecular cargo or mechanism linking KBP to microtubule integrity
    • Mitochondrial mislocalization vs primary microtubule defect not disentangled
  4. 2010 High

    Discovery of the SCG10 interaction supplied a microtubule-destabilizing effector, explaining how KBP influences microtubule dynamics without binding microtubules itself.

    Evidence yeast two-hybrid, co-immunoprecipitation, PC12 NGF-differentiation knockdown, zebrafish epistasis, and negative in vitro microtubule-binding assay

    PMID:20621975

    Open questions at the time
    • Did not show how KBP delivers SCG10 to its site of action
    • Relationship between SCG10 and the Kif1B motor not yet established
  5. 2013 Medium

    Reassessment in patient fibroblasts shifted KBP away from a mitochondrial role toward a cytoskeletal cross-linking function relevant to neuronal development.

    Evidence patient fibroblast respiratory chain assays, immunofluorescence co-localization with actin/tubulin, and SH-SY5Y neurite assays

    PMID:23427148

    Open questions at the time
    • Contradicts earlier mitochondrial localization without fully reconciling cell-type differences
    • Molecular nature of actin-MT cross-linking not defined
  6. 2016 High

    Defining the Kif1B→KBP→SCG10 transport axis unified prior interactions into a single pathway controlling growth-cone microtubule stability and axon extension.

    Evidence zebrafish genetic mutants with in vivo SCG10 transport imaging, SCG10-overexpression rescue, and microtubule stability assays

    PMID:27358458

    Open questions at the time
    • Did not establish whether the same axis operates outside developing axons
    • Excludes mitochondrial transport as the relevant cargo without explaining earlier mitochondrial phenotypes
  7. 2017 High

    A pluripotency-specific degradation circuit revealed post-translational control of KBP that links it to mitochondrial biogenesis via Kif1Bα.

    Evidence mass spectrometry, Lys501 acetylation mapping, GCN5L1 acetyltransferase assay, and genetic knockouts/rescue in mouse embryonic stem cells

    PMID:28319092

    Open questions at the time
    • Whether this acetylation-degradation axis operates in neurons is not addressed
    • Mechanism by which KBP stabilization expands mitochondria beyond Kif1Bα dependence not detailed
  8. 2017 Medium

    Identification of a Kif15 interaction extended KBP's adaptor role from interphase axons to the mitotic spindle.

    Evidence mitotic co-immunoprecipitation and siRNA knockdown with chromosome alignment and kinetochore fiber readouts

    PMID:28445502

    Open questions at the time
    • Single lab with Co-IP and knockdown only; no reconstitution of KBP-Kif15 regulation
    • How KBP targets Kif15 to the spindle equator mechanistically unknown
  9. 2017 High

    A knockout mouse confirmed the in vivo requirement for KBP in CNS and enteric innervation and added Ret as a partner relevant to gut neural crest colonization.

    Evidence Kif1bp knockout mouse phenotyping, histology, ENS colonization imaging, and KIF1BP–Ret co-immunoprecipitation

    PMID:29192291

    Open questions at the time
    • Mechanistic link between the Ret interaction and axon extension not defined
    • Whether Ret regulation involves the Kif1B/SCG10 axis unresolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved how KBP's distinct activities — Kif1B/SCG10 axonal transport, Kif15 spindle regulation, Ret signaling, and acetylation-dependent mitochondrial control — are coordinated or selected in different cell types.
  • No structural model of how TPR domains engage distinct kinesin partners
  • Cell-type-specific cytoskeletal vs mitochondrial role not reconciled
  • Direct biochemical mechanism of motor regulation not reconstituted

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 4 GO:0098772 molecular function regulator activity 2 GO:0008092 cytoskeletal protein binding 1
Localization
GO:0005815 microtubule organizing center 1 GO:0005856 cytoskeleton 1
Pathway
R-HSA-1266738 Developmental Biology 3 R-HSA-1640170 Cell Cycle 1
Partners
FBXO15GCN5L1KIF15KIF1BRETSCG10

Evidence

Reading pass · 10 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2005 KIAA1279 encodes a protein with two tetratricopeptide repeat (TPR) domains, and homozygous nonsense mutations in KIAA1279 cause Goldberg-Shprintzen syndrome (GOSHS), establishing that KBP is essential for both enteric and central nervous system development. Homozygosity mapping and identification of truncating mutations in patients with GOSHS (microcephaly, polymicrogyria, Hirschsprung disease) American journal of human genetics Medium 15883926
2005 KBP (KIF1 binding protein) interacts with KIF1Bα (a kinesin-3 family mitochondria-distributing motor) and co-immunoprecipitates with it from untransfected HEK293 cells. KBP localizes predominantly to mitochondria, and overexpression of a KBP deletion mutant or reduction of KBP via antisense causes mitochondrial aggregation, phenocopying reduced KIF1Bα motility activity. Yeast two-hybrid screen (using N-terminal KIF1C fragment homologous to KIF1B as bait), co-immunoprecipitation from endogenous and overexpressed conditions, immunofluorescence, motility assays BMC cell biology Medium 16225668
2008 In zebrafish, kbp is required for axonal outgrowth and maintenance. Live in vivo time-lapse imaging shows reduced speed of early axonal outgrowth in both peripheral and central nervous systems. Ultrastructural studies reveal disruption of axonal microtubules during outgrowth, and later-stage axons show mislocalized mitochondria and axonal degeneration in PNS, CNS, and ENS. Zebrafish kbp mutant characterization, in vivo time-lapse imaging of axonal outgrowth, electron microscopy ultrastructural analysis Development (Cambridge, England) High 18192286
2010 KBP interacts with SCG10 (a microtubule destabilizing protein) as identified by yeast two-hybrid screen and validated by co-immunoprecipitation. KBP-depleted PC12 cells are defective in NGF-induced differentiation and neurite outgrowth. Zebrafish studies reveal an epistatic interaction between KBP and SCG10 in vivo. No direct KBP–microtubule binding was detected in co-localization and in vitro binding assays. Yeast two-hybrid screen, co-immunoprecipitation validation, siRNA knockdown in PC12 cells with NGF-induced differentiation assay, zebrafish epistasis analysis, in vitro microtubule binding assay (negative result for direct KBP-MT interaction) Human molecular genetics High 20621975
2013 KBP does not co-localize with mitochondria in human control fibroblasts; instead it interacts with both actin filaments and tubulin cytoskeleton. Loss of KBP function (via nonsense mutations causing NMD) does not affect mitochondrial respiratory chain complex activity. KBP expression directly affects neurite growth in SH-SY5Y neuroblastoma cells, supporting a cytoskeletal (actin-MT cross-linking) mechanism for GOSHS neuronal developmental defects. Patient fibroblast analysis (respiratory chain enzyme assay), immunofluorescence co-localization in human fibroblasts, KBP overexpression/depletion in SH-SY5Y cells with neurite length assay, actin/tubulin interaction assays Human molecular genetics Medium 23427148
2013 Homozygous truncating mutation in the KBP gene (encoding a KIF1B-binding protein) causes fetal polymicrogyria, extending the GOSHS-associated phenotypic spectrum of KIAA1279 mutations. Genetic sequencing of fetal polymicrogyria cases identifying homozygous truncating KIAA1279 mutation Neurogenetics Low 24072599
2016 KBP is required for anterograde transport of SCG10 (Stathmin-2) to axon growth cones by the Kif1B motor. In kbp zebrafish mutants, SCG10 levels in growth cones are reduced, leading to altered microtubule stability and axon truncation. Overexpression of SCG10 suppresses axon truncation in kbp mutants, confirming the direct mechanistic link. Notably, loss of Kif1B or KBP does not inhibit mitochondrial transport (negative result). Zebrafish genetic mutants, in vivo live imaging of SCG10 transport, genetic epistasis (SCG10 overexpression rescuing kbp mutant axon phenotype), microtubule stability assays The Journal of neuroscience High 27358458
2017 In mouse embryonic stem cells (mESCs), KBP (encoded by Kif1bp) is acetylated on Lys501 by the combined action of TDH (which produces mitochondrial acetyl-CoA) and the acetyltransferase GCN5L1. This acetylation marks KBP for recognition and degradation by Fbxo15, an F-box protein transcriptionally controlled by pluripotency core factors. KBP degradation limits mitochondrial biogenesis in self-renewing mESCs; defects in KBP degradation cause unscheduled mitochondrial biogenesis, enhanced respiration, ROS production, and inhibited cell proliferation. Silencing of Kif1Bα reverts the aberrant mitochondrial increase caused by KBP stabilization. Mass spectrometry identification of KBP-Fbxo15 interaction, acetylation site mapping (Lys501), acetyltransferase assay (GCN5L1), genetic knockouts and knockdowns in mESCs, mitochondrial biogenesis assays, respiration/ROS measurements, embryoid body formation Nature cell biology High 28319092
2017 KBP acts as a novel mitotic interaction partner of Kif15 (a kinesin involved in spindle bipolarity). KBP promotes localization of Kif15 to the spindle equator close to chromosomes. Both Kif15 and KBP are required for alignment of all chromosomes to the metaphase plate and assembly of stable kinetochore fibers of correct length. Co-immunoprecipitation identifying KBP-Kif15 interaction in mitosis, siRNA knockdown of KBP and Kif15 with chromosome alignment and kinetochore fiber assembly phenotypic readouts, immunofluorescence PloS one Medium 28445502
2017 Kif1bp knockout mice die shortly after birth and show smaller brains, olfactory bulbs and anterior commissures, and defects in vagal and sympathetic innervation of the gut. KIF1BP interacts with Ret to regulate vagal innervation of the stomach. Colonization of the gut by neural crest-derived cells is delayed in Kif1bp-/- mice, demonstrating an essential in vivo role for KIF1BP in axon extension. Kif1bp knockout mouse generation and characterization, co-immunoprecipitation (KIF1BP–Ret interaction), histology, immunofluorescence of enteric nervous system colonization Scientific reports High 29192291

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1979 In vitro synthesis of a 9 kbp terminally redundant DNA carrying the infectivity of Moloney murine leukemia virus. Cell 173 88264
1991 Nucleotide sequence of 42 kbp of vaccinia virus strain WR from near the right inverted terminal repeat. The Journal of general virology 154 2045793
2005 Homozygous nonsense mutations in KIAA1279 are associated with malformations of the central and enteric nervous systems. American journal of human genetics 111 15883926
2006 Plasmid size up to 20 kbp does not limit effective in vivo lung gene transfer using compacted DNA nanoparticles. Gene therapy 106 16525478
1994 Formation of 50 kbp chromatin fragments in isolated liver nuclei is mediated by protease and endonuclease activation. FEBS letters 103 8082754
1991 Nucleotide sequence of the Autographa californica nuclear polyhedrosis 9.4 kbp EcoRI-I and -R (polyhedrin gene) region. Virology 100 1926775
2021 Effect of KBP-5074 on Blood Pressure in Advanced Chronic Kidney Disease: Results of the BLOCK-CKD Study. Hypertension (Dallas, Tex. : 1979) 97 33966452
1986 Gamma delta beta-thalassaemias 1 and 2 are the result of a 100 kbp deletion in the human beta-globin cluster. Nucleic acids research 78 3763397
2013 The 135 kbp mitochondrial genome of Agaricus bisporus is the largest known eukaryotic reservoir of group I introns and plasmid-related sequences. Fungal genetics and biology : FG & B 76 23428625
1992 Nucleotide sequence of 21.8 kbp of variola major virus strain Harvey and comparison with vaccinia virus. The Journal of general virology 76 1331292
1990 Molecular characterization of the vir regulon of Agrobacterium tumefaciens: complete nucleotide sequence and gene organization of the 28.63-kbp regulon cloned as a single unit. Plasmid 74 2194232
2008 KBP is essential for axonal structure, outgrowth and maintenance in zebrafish, providing insight into the cellular basis of Goldberg-Shprintzen syndrome. Development (Cambridge, England) 73 18192286
2000 Arrangement of the ILT gene cluster: a common null allele of the ILT6 gene results from a 6.7-kbp deletion. European journal of immunology 73 11169408
1990 Mapping of sequenced genes (700 kbp) in the restriction map of the Escherichia coli chromosome. Molecular microbiology 70 2187142
2005 The novel protein KBP regulates mitochondria localization by interaction with a kinesin-like protein. BMC cell biology 68 16225668
2014 The 203 kbp mitochondrial genome of the phytopathogenic fungus Sclerotinia borealis reveals multiple invasions of introns and genomic duplications. PloS one 64 25216190
1994 Nucleotide sequence of a 55 kbp region from the right end of the genome of a pathogenic African swine fever virus isolate (Malawi LIL20/1). The Journal of general virology 63 8021596
2014 A novel oral dual amylin and calcitonin receptor agonist (KBP-042) exerts antiobesity and antidiabetic effects in rats. American journal of physiology. Endocrinology and metabolism 62 24801386
2000 Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domain. The Journal of investigative dermatology 61 10692104
1991 DNA sequence and organization of genes in a 5.5 kbp EcoRI fragment mapping in the short unique segment of Marek's disease virus (strain RB1B). The Journal of general virology 59 1849977
2017 A novel dual amylin and calcitonin receptor agonist, KBP-089, induces weight loss through a reduction in fat, but not lean mass, while improving food preference. British journal of pharmacology 57 28109166
1991 A DNA region of 9 kbp contains all genes necessary for gas vesicle synthesis in halophilic archaebacteria. Molecular microbiology 55 1956294
2014 Mitochondrial genome of Phlebia radiata is the second largest (156 kbp) among fungi and features signs of genome flexibility and recent recombination events. PloS one 52 24824642
1997 Detection of higher-order 50- and 10-kbp DNA fragments before apoptotic internucleosomal cleavage after transient cerebral ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 46 9143220
1986 A 3.6-kbp segment from the vir region of Ti plasmids contains genes responsible for border-sequence-directed production of T region circles in E. coli. The EMBO journal 46 15966100
2020 The 206 kbp mitochondrial genome of Phanerochaete carnosa reveals dynamics of introns, accumulation of repeat sequences and plasmid-derived genes. International journal of biological macromolecules 45 32562727
2017 The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells. Nature cell biology 45 28319092
1995 Genomic analysis of a transposition-deletion variant of orf virus reveals a 3.3 kbp region of non-essential DNA. The Journal of general virology 45 8847502
2016 KBP-088, a novel DACRA with prolonged receptor activation, is superior to davalintide in terms of efficacy on body weight. American journal of physiology. Endocrinology and metabolism 43 26908506
1996 The DDX1 gene maps within 400 kbp 5' to MYCN and is frequently coamplified in human neuroblastoma. Genes, chromosomes & cancer 43 8834178
1991 Coregulation of the Kluyveromyces lactis lactose permease and beta-galactosidase genes is achieved by interaction of multiple LAC9 binding sites in a 2.6 kbp divergent promoter. Nucleic acids research 43 1923819
1988 Cloning and expression of chicken p54c-ets cDNAs: the first p54c-ets coding exon is located into the 40.0 kbp genomic domain unrelated to v-ets. Oncogene research 43 3041344
1991 Escherichia coli molecular genetic map (1500 kbp): update II. Molecular microbiology 42 1779754
2004 Linkage disequilibrium and sequence diversity in a 500-kbp region around the adh1 locus in elite maize germplasm. TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik 41 15300382
1992 A 17.6 kbp region located upstream of the rabbit WAP gene directs high level expression of a functional human protein variant in transgenic mouse milk. FEBS letters 40 1299629
2008 Analysis of a 30 kbp plasmid encoding histidine decarboxylase gene in Tetragenococcus halophilus isolated from fish sauce. International journal of food microbiology 39 18573560
2002 Familial interstitial 570 kbp deletion of the UBE3A gene region causing Angelman syndrome but not Prader-Willi syndrome. American journal of medical genetics 39 12210318
2016 The Potassium Binding Protein Kbp Is a Cytoplasmic Potassium Sensor. Structure (London, England : 1993) 37 27112601
2010 KBP interacts with SCG10, linking Goldberg-Shprintzen syndrome to microtubule dynamics and neuronal differentiation. Human molecular genetics 37 20621975
1997 A large-insert (130 kbp) bacterial artificial chromosome library of the rice blast fungus Magnaporthe grisea: genome analysis, contig assembly, and gene cloning. Fungal genetics and biology : FG & B 37 9290247
2022 Does receptor balance matter? - Comparing the efficacies of the dual amylin and calcitonin receptor agonists cagrilintide and KBP-336 on metabolic parameters in preclinical models. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 34 36242844
2016 The dual amylin- and calcitonin-receptor agonist KBP-042 increases insulin sensitivity and induces weight loss in rats with obesity. Obesity (Silver Spring, Md.) 34 27296301
1994 Analysis of the nucleotide sequence of 53 kbp from the right terminus of the genome of variola major virus strain India-1967. Virus research 34 7856312
1990 Transcription and sequence studies of a 4.3-kbp fragment from a ds-DNA eukaryotic algal virus. Virology 34 2345963
2021 KBP-066A, a long-acting dual amylin and calcitonin receptor agonist, induces weight loss and improves glycemic control in obese and diabetic rats. Molecular metabolism 33 34214708
1985 (A gamma delta beta)0-Thalassaemia in Blacks is due to a deletion of 34 kbp of DNA. British journal of haematology 33 2578804
1995 Characterization of a 3.5-kbp plasmid from Helicobacter pylori. Plasmid 32 7480168
2015 KBP-042 improves bodyweight and glucose homeostasis with indices of increased insulin sensitivity irrespective of route of administration. European journal of pharmacology 31 26027795
1994 Nucleotide sequence analysis of a 21-kbp region of the genome of human herpesvirus-6 containing homologues of human cytomegalovirus major immediate-early and replication genes. Virology 30 7941342
1992 Novel aerobic 2-aminobenzoate metabolism. Purification and characterization of 2-aminobenzoate-CoA ligase, localisation of the gene on a 8-kbp plasmid, and cloning and sequencing of the gene from a denitrifying Pseudomonas sp. European journal of biochemistry 29 1315272
1990 A physical map of the human salivary proline-rich protein gene cluster covers over 700 kbp of DNA. Genomics 29 2307469
2017 Optimization of tolerability and efficacy of the novel dual amylin and calcitonin receptor agonist KBP-089 through dose escalation and combination with a GLP-1 analog. American journal of physiology. Endocrinology and metabolism 28 28292761
1992 Analysis of nucleotide sequence of the rightmost 43 kbp of herpesvirus saimiri (HVS) L-DNA: general conservation of genetic organization between HVS and Epstein-Barr virus. Virology 28 1314457
2019 The Dual Amylin and Calcitonin Receptor Agonist KBP-088 Induces Weight Loss and Improves Insulin Sensitivity Superior to Chronic Amylin Therapy. The Journal of pharmacology and experimental therapeutics 27 31028106
2000 Dielectric relaxation measurements of 12 kbp plasmid DNA. Biochimica et biophysica acta 27 10978517
2021 The dual amylin and calcitonin receptor agonist KBP-089 and the GLP-1 receptor agonist liraglutide act complimentarily on body weight reduction and metabolic profile. BMC endocrine disorders 26 33413317
2000 Isolation of a Spodoptera exigua baculovirus recombinant with a 10.6 kbp genome deletion that retains biological activity. The Journal of general virology 26 10993945
1990 Generation of a 50,000-member human DNA library with an average DNA insert size of 75-100 kbp in a bacteriophage P1 cloning vector. The New biologist 26 1964591
2016 Kif1B Interacts with KBP to Promote Axon Elongation by Localizing a Microtubule Regulator to Growth Cones. The Journal of neuroscience : the official journal of the Society for Neuroscience 25 27358458
2013 KBP-cytoskeleton interactions underlie developmental anomalies in Goldberg-Shprintzen syndrome. Human molecular genetics 25 23427148
2017 The Dual Amylin- and Calcitonin-Receptor Agonist KBP-042 Works as Adjunct to Metformin on Fasting Hyperglycemia and HbA1c in a Rat Model of Type 2 Diabetes. The Journal of pharmacology and experimental therapeutics 24 28438778
2013 Homozygous truncating mutation of the KBP gene, encoding a KIF1B-binding protein, in a familial case of fetal polymicrogyria. Neurogenetics 24 24072599
2005 A novel transgenic mouse model reveals humanlike regulation of an 8-kbp human TERT gene promoter fragment in normal and tumor tissues. Cancer research 24 15735002
2018 MACF1 Overexpression by Transfecting the 21 kbp Large Plasmid PEGFP-C1A-ACF7 Promotes Osteoblast Differentiation and Bone Formation. Human gene therapy 23 29334773
2017 Role of Kif15 and its novel mitotic partner KBP in K-fiber dynamics and chromosome alignment. PloS one 21 28445502
2016 Common findings of bla CTX-M-55-encoding 104-139 kbp plasmids harbored by extended-spectrum β-lactamase-producing Escherichia coli in pork meat, wholesale market workers, and patients with urinary tract infection in Vietnam. Current microbiology 21 27942843
2013 [Ten-year evolution in non-small-cell lung cancer according to sex. Results of the KBP-2010-CPHG study by the College of General Hospital Respiratory Physicians]. Revue des maladies respiratoires 21 25433585
2007 Ribonucleoprotein-masked nicks at 50-kbp intervals in the eukaryotic genomic DNA. Proceedings of the National Academy of Sciences of the United States of America 21 17848525
2004 Homogeneous polymerase chain reaction nucleobase quenching assay to detect the 1-kbp deletion in CLN3 that causes Batten disease. The Journal of molecular diagnostics : JMD 21 15269304
2004 Lung cancer among women in France. Analysis of the 904 French women with lung cancer included in the KBP-2000-CPHG study of the French College of General Hospital-based Pneumologists (CPHG). Lung cancer (Amsterdam, Netherlands) 21 15301868
1990 Organization and nucleotide sequence of ribosomal RNA genes on a circular 73 kbp DNA from the colourless flagellate Astasia longa. Current genetics 21 2113436
2005 Characterization of a 2.6 kbp variable region within a class 1 integron found in an Acinetobacter baumannii strain isolated from a horse. The Journal of antimicrobial chemotherapy 20 15681585
1994 Molecular characterization and determination of the coding capacity of the genome of equine herpesvirus type 2 between the genome coordinates 0.235 and 0.258 (the EcoRI DNA fragment N; 4.2 kbp). Virus genes 20 7871763
2012 6.7-kbp deletion in LILRA3 (ILT6) gene is associated with later onset of the multiple sclerosis in a Polish population. Human immunology 19 23238213
1998 Capillary electrophoretic separation of 1 to 10 kbp sized dsDNA using poly(ethylene oxide) solutions in the presence of electroosmotic counterflow. Electrophoresis 19 9932807
1996 Analysis of the nucleotide sequence of 23.8 kbp from the left terminus of the genome of variola major virus strain India-1967. Virus research 19 8725113
2019 Evidence of slight improvement in five-year survival in non-small-cell lung cancer over the last 10 years: Results of the French KBP-CPHG real-world studies. Bulletin du cancer 18 30803715
2000 Extensive methylation of a part of the CpG island located 3.0-4.5 kbp upstream to the chicken alpha-globin gene cluster may contribute to silencing the globin genes in non-erythroid cells. Journal of molecular biology 18 10843840
2021 Safety, tolerability and pharmacokinetic characterisation of DACRA KBP-042 in healthy male subjects. British journal of clinical pharmacology 17 34019711
2015 Characterization of preclinical in vitro and in vivo pharmacokinetics properties for KBP-7018, a new tyrosine kinase inhibitor candidate for treatment of idiopathic pulmonary fibrosis. Drug design, development and therapy 17 26273193
2008 Fluorescence lifetime correlation spectroscopy reveals compaction mechanism of 10 and 49 kbp DNA and differences between polycation and cationic surfactant. The journal of physical chemistry. B 17 19367896
2004 Haplotype analysis of BRCA1 gene reveals a new gene rearrangement: characterization of a 19.9 KBP deletion. European journal of human genetics : EJHG 17 15162129
1997 Enhancer element, repetitive sequences and gene organization in an 8-kbp region containing the polyhedrin gene of the Spodoptera littoralis nucleopolyhedrovirus. Archives of virology 17 9155869
1995 New open reading frames, one of which is similar to the nifV gene of Azotobacter vinelandii, found on a 12.5 kbp fragment of chromosome IV of Saccharomyces cerevisiae. Yeast (Chichester, England) 17 8533471
2021 The Non-Steroidal Mineralocorticoid Receptor Antagonist KBP-5074 Limits Albuminuria and has Improved Therapeutic Index Compared With Eplerenone in a Rat Model With Mineralocorticoid-Induced Renal Injury. Frontiers in pharmacology 16 34248613
2014 Nucleotide-type chemical shift assignment of the encapsulated 40 kbp dsDNA in intact bacteriophage T7 by MAS solid-state NMR. Journal of biomolecular NMR 16 24875850
1998 First report on the systematic sequencing of the small genome of Encephalitozoon cuniculi (Protozoa, Microspora): gene organization of a 4.3 kbp region on chromosome I. Microbial & comparative genomics 16 11013707
1990 Escherichia coli molecular genetic map (1000 kbp): update I. Molecular microbiology 16 2287271
2001 Sequencing of a 4.3 kbp region of chromosome 2 of Candida albicans reveals the presence of homologues of SHE9 from Saccharomyces cerevisiae and of bacterial phosphatidylinositol-phospholipase C. Yeast (Chichester, England) 15 11378898
1998 A highly conserved genomic region in baculoviruses: sequence analysis of an 11.3 kbp DNA fragment (46.5-55.1 m.u.) of the Spodoptera exigua multicapsid nucleopolyhedrovirus. Virus research 15 9725671
2017 Kif1bp loss in mice leads to defects in the peripheral and central nervous system and perinatal death. Scientific reports 14 29192291
2003 Sequence analysis of a 5.1 kbp region of the Spodoptera frugiperda multicapsid nucleopolyhedrovirus genome that comprises a functional ecdysteroid UDP-glucosyltransferase (egt) gene. Virus genes 14 14501191
1993 Analysis of the nucleotide sequence of a 43 kbp segment of the genome of variola virus India-1967 strain. Virus research 14 8109158
2023 Treatment sequencing using the dual amylin and calcitonin receptor agonist KBP-336 and semaglutide results in durable weight loss. European journal of pharmacology 13 37329973
2020 The Dual Amylin and Calcitonin Receptor Agonist, KBP-066, Induces an Equally Potent Weight Loss Across a Broad Dose Range While Higher Doses May Further Improve Insulin Action. The Journal of pharmacology and experimental therapeutics 13 31992608
2020 Dose Frequency Optimization of the Dual Amylin and Calcitonin Receptor Agonist KBP-088: Long-Lasting Improvement in Food Preference and Body Weight Loss. The Journal of pharmacology and experimental therapeutics 13 32071103
2007 Characterisation of pSMA23, a 3.5 kbp plasmid of Lactobacillus casei, and application for heterologous expression in Lactobacillus. Plasmid 13 17961648
2003 A 3.4-kbp transcript of ZNF331 is solely expressed in follicular thyroid adenomas. Cytogenetic and genome research 13 14610350
2021 An evaluation of KBP-5074 in advanced chronic kidney disease with uncontrolled hypertension. Expert opinion on investigational drugs 12 34595995
2005 Nick-forming sequences may be involved in the organization of eukaryotic chromatin into approximately 50 kbp loops. Histochemistry and cell biology 12 16195888

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