Affinage

KAT7

Histone acetyltransferase KAT7 · UniProt O95251

Length
611 aa
Mass
70.6 kDa
Annotated
2026-04-28
100 papers in source corpus 64 papers cited in narrative 65 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

KAT7 (HBO1/MYST2) is a MYST-family lysine acetyltransferase that serves as the catalytic subunit of two distinct tetrameric complexes—JADE-containing complexes that preferentially acetylate H4K5/K8/K12 and BRPF-containing complexes that target H3K14—and is the principal enzyme responsible for global H3K14 acetylation in mammalian cells (PMID:21149574, PMID:18684714, PMID:26620551). KAT7 regulates DNA replication licensing by acetylating histone H4 at origins to facilitate Cdt1-dependent MCM2-7 loading, a process controlled by Geminin inhibition and by Plk1/CDK1 phosphorylation of HBO1 during mitosis (PMID:20129055, PMID:18250300, PMID:16428461); it also promotes transcription by depositing H3K14ac at gene bodies and promoters to support RNA Pol II processivity and de novo gene activation in stem cells, hematopoietic progenitors, and leukemia cells (PMID:31827282, PMID:36641753, PMID:34724565). Beyond canonical acetylation, KAT7 catalyzes diverse acyl modifications including propionylation, butyrylation, crotonylation, benzoylation, lactylation, and acetoacetylation of histones and non-histone substrates such as vimentin, LDHA, CANX, and RFX1, and participates in nucleotide excision repair by facilitating XPC recruitment and chromatin remodeling at UV damage sites (PMID:34259319, PMID:38670996, PMID:37382194, PMID:28719581, PMID:37424170). KAT7 protein stability is regulated by multiple ubiquitin-dependent degradation pathways (Fbxw15/SCF, CRL4-DDB2, HUWE1) counterbalanced by USP25 deubiquitination and stabilizing phosphorylation by PKD1 (PMID:23319590, PMID:26572825, PMID:32555450, PMID:30745998, PMID:33014433).

Mechanistic history

Synthesis pass · year-by-year structured walk · 16 steps
  1. 1999 High

    The discovery that HBO1 physically interacts with ORC1 and possesses intrinsic histone H3/H4 acetyltransferase activity established a direct molecular link between histone acetylation and the replication origin machinery.

    Evidence Yeast two-hybrid and co-immunoprecipitation from human cell extracts with in vitro HAT assay

    PMID:10438470

    Open questions at the time
    • Substrate specificity for individual lysines was not determined
    • Functional consequence for DNA replication was not tested
    • Identity of other complex subunits was unknown
  2. 2001 High

    Identification of direct HBO1–MCM2 interaction through the C2HC zinc finger domain extended the replication connection beyond ORC1, suggesting HBO1 functions at multiple steps of pre-RC assembly.

    Evidence Yeast two-hybrid, pulldown, co-immunoprecipitation, and reverse two-hybrid suppressor screen

    PMID:11278932

    Open questions at the time
    • Whether HBO1 enzymatic activity was required for MCM loading was untested
    • In vivo relevance to DNA replication had not been demonstrated
  3. 2006 High

    Loss-of-function experiments in human cells and Xenopus extracts demonstrated that HBO1 is required for MCM2-7 chromatin loading and DNA replication, establishing its functional role as a licensing factor.

    Evidence siRNA knockdown in human cells and immunodepletion from Xenopus egg extracts with chromatin fractionation and replication assays

    PMID:16428461

    Open questions at the time
    • Whether HAT catalytic activity per se was required was not separated from scaffolding function
    • The relevant histone substrate at origins was not identified
  4. 2008 High

    Two key advances defined the regulatory framework: Plk1/CDK1 phosphorylation of HBO1 during mitosis primes it for G1 licensing function, and JADE1 was identified as the scaffold subunit that confers H4 acetylation specificity to the HBO1 complex.

    Evidence In vitro kinase assays with phospho-mutagenesis and MCM loading readout; reconstituted in vitro HAT assay with JADE1 mutants

    PMID:18250300 PMID:18684714

    Open questions at the time
    • Structural basis for JADE1-mediated substrate switching was unknown
    • Whether BRPF scaffolds confer different specificity had not been tested
  5. 2008 High

    Cdt1 was shown to recruit HBO1 to replication origins in G1 phase, and HBO1 acts as a coactivator of Cdt1-dependent licensing, directly coupling acetyltransferase recruitment to the licensing pathway.

    Evidence Reciprocal co-immunoprecipitation, ChIP at origins, and rereplication assay

    PMID:18832067

    Open questions at the time
    • Geminin's mechanism of HBO1 inhibition was not fully elucidated
    • Whether HBO1 HAT activity versus scaffolding drove rereplication was unclear
  6. 2010 High

    A HAT-dead HBO1 mutant at origins failed to load MCM, and Geminin was shown to inhibit HBO1 HAT activity in the Cdt1-HBO1 complex, proving that catalytic acetylation of H4 at origins is the mechanistic basis for licensing facilitation.

    Evidence HAT-defective mutagenesis combined with ChIP, MCM loading assays, and in vitro HAT assays

    PMID:20129055

    Open questions at the time
    • Whether H3K14ac at origins also contributes remained unaddressed
    • The chromatin structural change induced by H4ac at origins was not resolved
  7. 2010 High

    HBO1 knockout mice revealed that HBO1 is the principal H3K14 acetyltransferase in vivo (>90% of global H3K14ac lost), and that its essential developmental role is in gene expression rather than bulk DNA replication.

    Evidence Conditional knockout mouse with global histone modification analysis and proliferation assay

    PMID:21149574

    Open questions at the time
    • How HBO1 loss causes embryonic lethality despite normal replication was not mechanistically resolved
    • Cell-type-specific versus global requirements were not dissected
  8. 2011 High

    BRD1/BRPF2 was identified as an alternative scaffold that forms a distinct HBO1 complex directing H3K14 acetylation, establishing the two-complex paradigm (JADE→H4ac vs. BRPF→H3K14ac) and linking HBO1-BRD1 to erythroid gene activation.

    Evidence Biochemical complex purification, ChIP-seq, and conditional knockout mouse in fetal liver

    PMID:21753189

    Open questions at the time
    • Whether BRPF1 and BRPF3 confer identical or distinct specificities was untested
    • Relative contributions of the two complexes at different genomic loci were unclear
  9. 2015 High

    BRPF3-HBO1 was shown to acetylate H3K14 at replication origins and promote origin activation (CDC45 loading) rather than MCM loading, revealing a second, distinct replication function for HBO1 complexes; concurrently, ATM/ATR-dependent phosphorylation and CRL4-DDB2-mediated degradation of HBO1 after UV damage established a DNA damage–responsive regulatory circuit.

    Evidence ChIP-seq, DNA fiber assay, RNAi, and phospho-mutagenesis with ubiquitination assays

    PMID:26572825 PMID:26620551

    Open questions at the time
    • How BRPF3-directed H3K14ac promotes CDC45 loading mechanistically was not resolved
    • Whether origin firing and NER functions are coordinated was unknown
  10. 2016 High

    HBO1 was found to participate in centromere maintenance by interacting with M18BP1 and antagonizing Suv39h1-mediated H3K9me3, revealing an unexpected role in epigenetic identity at centromeres.

    Evidence Co-immunoprecipitation, CRISPR knockout, ChIP, tethering assay, and mitosis imaging

    PMID:27270040

    Open questions at the time
    • Which HBO1 complex (JADE vs. BRPF) mediates centromere function was not determined
    • Whether centromere defects contribute to developmental lethality was untested
  11. 2019 High

    HBO1 was identified as an essential dependency in AML leukemia stem cells: H3K14ac deposited by HBO1 sustains RNA Pol II processivity at HOXA cluster genes, and a competitive acetyl-CoA inhibitor (WM-3835) demonstrated therapeutic potential.

    Evidence shRNA screen, CRISPR domain screening, ChIP-seq, competitive inhibitor development, primary patient AML samples

    PMID:31827282

    Open questions at the time
    • In vivo pharmacokinetics and toxicity of HBO1 inhibitors were not established
    • Whether normal HSC function tolerates HBO1 inhibition was unknown at this time
  12. 2021 High

    HBO1 was demonstrated to be a versatile acyltransferase capable of catalyzing propionylation, butyrylation, and crotonylation in addition to acetylation, expanding its enzymatic repertoire beyond canonical histone acetylation.

    Evidence In vitro acylation assays with multiple acyl-CoA donors, mass spectrometry, ChIP-seq, and CRISPR KO

    PMID:34259319

    Open questions at the time
    • Physiological regulation of acyl-CoA selectivity was not determined
    • Functional consequences of individual acyl marks versus acetylation were largely unexplored
  13. 2022 High

    HBO1's H3K14ac was shown to be essential for hematopoietic stem cell quiescence maintenance; loss forces HSC cycling and exhaustion, linking HBO1-dependent chromatin state to stem cell self-renewal.

    Evidence Dual conditional knockout mouse systems, competitive transplantation, ChIP-seq, and RNA-seq

    PMID:34724565

    Open questions at the time
    • Whether pharmacological HBO1 inhibition phenocopies genetic deletion in HSCs was not tested
    • The specific target genes whose H3K14ac loss drives quiescence exit were not fully delineated
  14. 2023 High

    In neural stem cells, HBO1/H3K14ac was found to be dispensable for maintaining already-active transcription but indispensable for de novo gene activation, establishing a 'priming' model for HBO1-dependent chromatin accessibility.

    Evidence Conditional KAT7 knockout with re-expression rescue, ChIP-seq, RNA-seq, and differentiation assays

    PMID:36641753

    Open questions at the time
    • Whether this priming function applies universally across cell types was unknown
    • The mechanism by which H3K14ac enables de novo activation but is dispensable for ongoing transcription was not resolved
  15. 2024 High

    Structural determination of the JADE PZP domain on the nucleosome revealed how unmethylated H3K4 recognition by JADE directs HBO1 H4 acetylation, while H3K4 hypermethylation shifts substrate selectivity, providing a structural basis for the two-complex substrate-switching paradigm; separately, HBO1 was shown to function as a lactyltransferase catalyzing H3K9la at promoters.

    Evidence Crystal/cryo-EM structure of PZP-nucleosome complex with ChIP-seq; in vitro lactyltransferase assay with mutagenesis and CUT&Tag

    PMID:38448574 PMID:38670996

    Open questions at the time
    • Full cryo-EM structure of the complete tetrameric complex on a nucleosome is still lacking
    • Physiological stimuli that regulate lactyltransferase versus acetyltransferase activity are unknown
  16. 2025 High

    Post-translational crotonylation of KAT7 itself at K432 was shown to competitively antagonize its acetylation at the same residue, diminishing HAT activity and linking DNA damage signaling to procentriole formation, revealing a novel autoregulatory mechanism.

    Evidence Site-specific mutagenesis, in vitro HAT assay, ChIP-qPCR, and mass spectrometry

    PMID:40064919

    Open questions at the time
    • Whether other acylation marks on KAT7 similarly regulate activity is untested
    • The full spectrum of procentriole genes affected was not determined

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key open questions include: the structural basis for full tetrameric HBO1 complex engagement with nucleosomes, the physiological logic governing acyl-CoA donor selectivity, whether HBO1's replication licensing and transcriptional functions can be pharmacologically uncoupled, and the therapeutic window of HBO1 inhibition in normal versus malignant hematopoiesis.
  • No complete cryo-EM structure of HBO1 tetrameric complex on nucleosome
  • Acyl-CoA selectivity mechanism unresolved
  • Therapeutic window between normal HSC toxicity and AML efficacy not established

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016740 transferase activity 8 GO:0140096 catalytic activity, acting on a protein 8 GO:0140110 transcription regulator activity 7 GO:0042393 histone binding 3
Localization
GO:0005694 chromosome 4 GO:0005634 nucleus 3
Pathway
R-HSA-4839726 Chromatin organization 7 R-HSA-1266738 Developmental Biology 6 R-HSA-69306 DNA Replication 5 R-HSA-74160 Gene expression (Transcription) 5 R-HSA-1643685 Disease 4 R-HSA-73894 DNA Repair 2
Partners
BRPF2BRPF3CDT1ING4JADE1MCM2ORC1SMAD4
Complex memberships
HBO1-BRPF1/2/3-ING4/5-MEAF6HBO1-JADE1/2/3-ING4/5-MEAF6

Evidence

Reading pass · 65 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1999 HBO1 (KAT7) was identified as a novel protein that physically interacts with human ORC1, the largest subunit of the origin recognition complex, and exists as part of a multisubunit complex possessing histone H3 and H4 acetyltransferase activities. Yeast two-hybrid, co-immunoprecipitation from human cell extracts, in vitro HAT assay The Journal of biological chemistry High 10438470
2000 HBO1 interacts with the androgen receptor (AR) in a ligand-enhanced manner and acts as a transcriptional repressor of AR-mediated transcription through an N-terminal repression domain; HBO1 localizes to the nucleus. Yeast two-hybrid, GST pulldown, co-immunoprecipitation, immunofluorescence, transient transfection reporter assay The Journal of biological chemistry High 10930412
2001 HBO1 directly interacts with MCM2 through its C2HC zinc finger domain; an N-terminal domain of MCM2 is required for HBO1 binding; genetic suppressor analysis confirmed the direct and specific nature of the zinc finger–MCM2 interaction. Yeast two-hybrid, in vitro pulldown, co-immunoprecipitation, reverse two-hybrid suppressor screen, in vivo binding assay The Journal of biological chemistry High 11278932
2005 CDK11(p58) interacts with HBO1 and enhances its histone acetyltransferase activity both in vitro and in cells; CDK11(p58) and HBO1 co-localize in the nucleus. Yeast two-hybrid, co-immunoprecipitation, in vitro HAT assay, immunofluorescence co-localization FEBS letters Medium 15963510
2006 Hbo1 is a positive regulatory factor for pre-replicative complex (pre-RC) assembly: siRNA depletion in human cells prevents MCM2-7 chromatin loading while ORC and Cdc6 loading remain normal; immunodepletion of Xenopus Hbo1 abolishes DNA replication and MCM2-7 chromatin binding, rescued by recombinant Cdt1. siRNA knockdown, immunodepletion of Xenopus egg extracts, chromatin fractionation, DNA replication assay Molecular and cellular biology High 16428461
2006 HBO1 interacts with the N-terminal domain of progesterone receptor (PR) through its MYST domain in a ligand-dependent manner and induces SRC-1-dependent coactivation of PR-mediated transcription; HBO1 co-localizes with PR–SRC-1 complex in nuclear speckles upon hormone treatment. Yeast two-hybrid, GST pulldown, co-immunoprecipitation, transient transfection reporter assay, immunofluorescence/confocal microscopy Molecular endocrinology Medium 16645042
2006 HBO1 inhibits NF-κB activity through its N-terminal serine-rich region (not the acetyltransferase domain) by sequestering an essential NF-κB coactivator rather than by blocking NF-κB DNA binding. Transient transfection reporter assay, EMSA, mutational analysis Biochemical and biophysical research communications Medium 16997280
2007 p53 physically interacts with Hbo1 and negatively regulates its HAT activity; physiological stresses (hyperosmotic shock, replication fork arrest) inhibit Hbo1 HAT activity in a p53-dependent manner; hyperosmotic stress during G1 specifically inhibits MCM2-7 chromatin loading via this pathway. Co-immunoprecipitation, in vitro HAT assay, chromatin fractionation, siRNA knockdown Molecular and cellular biology High 17954561
2007 FAD24 interacts with HBO1 and co-localizes with it at replication origins during late mitosis; FAD24 knockdown reduces HBO1 recruitment to origins of replication and impairs mitotic clonal expansion during adipocyte differentiation. Co-immunoprecipitation, chromatin immunoprecipitation (ChIP), siRNA knockdown, confocal co-localization The Journal of biological chemistry Medium 18029353
2008 HBO1 directly interacts with Cdt1 and associates with replication origins during G1 phase in a Cdt1-dependent, Geminin-independent manner; HBO1 enhances Cdt1-dependent rereplication, acting as a coactivator of the Cdt1 licensing factor. Co-immunoprecipitation, chromatin immunoprecipitation (ChIP), rereplication assay Genes & development High 18832067
2008 Plk1 phosphorylates Hbo1 on Ser-57 in vitro and in vivo during mitosis; Cdk1 phosphorylates Hbo1 on Thr-85/88 creating a docking site for Plk1; Hbo1-S57A overexpression causes G1/S arrest, inhibits MCM chromatin loading, and reduces DNA replication. Yeast two-hybrid, in vitro kinase assay, co-immunoprecipitation, chromatin fractionation, cell-cycle analysis Proceedings of the National Academy of Sciences of the United States of America High 18250300
2008 Jade-1/1L acts as a crucial co-factor for HBO1-mediated histone H4 acetylation; co-expression synergistically increases H4 acetylation; PHD fingers of Jade-1 are required for HBO1-mediated nucleosomal H4 acetylation in vivo and in vitro; ING4/5 interaction with HBO1 requires Jade-1L or Jade-3 but not the short Jade-1 isoform. Co-immunoprecipitation, in vitro HAT assay with reconstituted oligonucleosomes, siRNA knockdown, overexpression, mutational analysis The Journal of biological chemistry High 18684714
2009 HBO1 HAT complexes contain PHD finger domains from ING4/5 and JADE1/2/3 subunits that interact with the histone H3 N-terminal tail with distinct specificity toward H3K4 methylation status; combinatorial PHD finger action regulates chromatin binding, substrate specificity, and cell growth; HBO1 complexes are enriched throughout gene coding regions, supporting a role in transcription elongation. Biochemical HAT assays, ChIP-chip, pulldown with modified histone peptides, mutagenesis, cell growth assays Molecular cell High 19187766
2009 Recombinant Hbo1 acetylates nucleosomal histone H4 in vitro with a preference for lysines 5 and 12. In vitro HAT assay with nucleosomal substrate, mass spectrometry Gene High 19393168
2010 HBO1 HAT activity is required for DNA replication licensing: a HAT-defective HBO1 mutant bound at origins cannot load the MCM complex; H4 acetylation at origins is cell-cycle regulated with maximal activity at G1/S; Geminin inhibits HBO1 acetylase activity in a Cdt1-HBO1 complex context and inhibits H4 acetylation and licensing in vivo. HAT-defective mutagenesis, ChIP, MCM loading assay, co-immunoprecipitation, in vitro HAT assay Molecular cell High 20129055
2010 HBO1 is required for chromatin unfolding induced by Cdt1 that facilitates MCM loading; Cdt1-induced chromatin decondensation in G1 requires HBO1 HAT activity and H4 modifications; HDAC11 antagonizes this process by binding Cdt1 and suppressing chromatin accessibility. siRNA knockdown, live-cell imaging of chromatin decondensation, MCM loading assay, co-immunoprecipitation Cell cycle Medium 20980834
2010 Knockout of HBO1 in mice results in more than 90% reduction of H3K14 acetylation with no reduction at other histone residues; HBO1 deficiency causes embryonic lethality at the 10-somite stage with decreased expression of developmental regulator genes, high cell death, and DNA fragmentation, but no defects in DNA replication or cell proliferation. Conditional knockout mouse, ChIP for histone modifications, global acetylation analysis, cell proliferation assay Molecular and cellular biology High 21149574
2010 ING4 forms homodimers through its N-terminal coiled-coil domain; the dimeric ING4 has two identical and independent PHD finger binding sites for H3K4me3, providing bivalent reading of chromatin to enhance HBO1 complex targeting. NMR, biophysical analysis, binding assays with histone peptides Journal of molecular biology High 20053357
2011 BRD1 (BRPF2) forms a novel HAT complex with HBO1, bridging HBO1 and its activator ING4; the Hbo1-Brd1 complex is the major H3K14 histone acetyltransferase required for transcriptional activation of erythroid developmental regulator genes in fetal liver erythropoiesis. Biochemical complex purification, Co-immunoprecipitation, ChIP-seq, conditional knockout mouse, genome-wide mapping Blood High 21753189
2011 Multiple PHD finger domains in ING4/5 and JADE subunits of HBO1 complexes bind histone H3 tail with distinct specificity toward H3K4 methylation; ING4/5 PHD domain association with HBO1-JADE determines growth inhibitory function; the p53/p21 pathway is a direct transcriptional target of HBO1-ING complexes. Biochemical dissection of protein domains, pulldown with modified peptides, ChIP-seq, cell proliferation assays, mutagenesis Molecular and cellular biology High 22144582
2011 JNK phosphorylates Cdt1 on Thr-29 in response to non-genotoxic stress, leading to rapid dissociation of HBO1 from replication origins and blocking DNA replication initiation; simultaneously, JNK phosphorylates Jun leading to increased HBO1 recruitment to stress-response target genes. Co-immunoprecipitation, ChIP, phospho-mutagenesis, DNA replication assay, kinase assay Molecular cell High 21856198
2012 Fbxw15 E3 ubiquitin ligase subunit directly interacts with HBO1 and mediates its ubiquitination at Lys-338 and proteasomal degradation in the cytoplasm; Mek1 triggers HBO1 phosphorylation and degradation in a Fbxw15-dependent manner; Fbxw15 modulation regulates H3K14 acetylation and cell proliferation via HBO1 levels. Co-immunoprecipitation, ubiquitination assay, siRNA knockdown, pulse-chase/stability assay The Journal of biological chemistry Medium 23319590
2012 JADE1 siRNA knockdown diminishes DNA synthesis and prevents chromatin recruitment of MCM7; the JADE1S-HBO1 complex specifically marks H4K5/K12 acetylation during epithelial cell proliferation, while JADE1L-HBO1 marks H3K14 after bulk proliferation. siRNA knockdown, BrdU incorporation assay, chromatin fractionation, co-immunoprecipitation, tissue immunostaining The American journal of pathology Medium 23159946
2012 Plk1 phosphorylation of Hbo1 mediates gemcitabine resistance in pancreatic cancer by transcriptionally increasing cFos expression and consequently elevating MDR1; Plk1 phosphorylation of Hbo1 is distinct from its role in DNA replication and acts in transcriptional regulation. siRNA knockdown, phospho-mutant overexpression, xenograft assay, qRT-PCR for downstream targets Molecular cancer therapeutics Medium 23188630
2013 Hbo1 is a substrate of cyclin E/CDK2; LMW-E/CDK2 complex phosphorylates Hbo1 at Thr-88 without affecting its HAT activity; coexpression of LMW-E/CDK2 with wild-type Hbo1 promotes cancer stem cell enrichment, whereas the T88 Hbo1 mutant reverses this phenotype. Protein microarray, in vitro kinase assay, phospho-mutagenesis, mammosphere/stem cell assay Cancer research Medium 23955388
2013 Hbo1 promotes destabilization of ERα through lysine 48-linked ubiquitination; Hbo1's acetyltransferase activity is linked to its ERα ubiquitination activity; Hbo1 knockdown increases ERα expression. Co-immunoprecipitation, ubiquitination assay, siRNA knockdown, Western blot Cancer science Medium 24125069
2014 HBO1-JADE1 complex undergoes cell cycle-dependent chromatin shuttling: JADE1S dissociates from chromatin in prophase, associates with cytoplasm, then reassociates with chromatin in telophase/early G1; cytoplasmic (but not chromatin-associated) JADE1 is phosphorylated; Aurora A kinase inhibition prevents JADE1S chromatin dissociation. Live-cell imaging, chromatin fractionation, flow cytometry, mass spectrometry of phosphorylated residues, pharmacological inhibition Cell cycle Medium 24739512
2015 BRPF3 forms a specific tetrameric complex with HBO1 (KAT7) that specifically acetylates histone H3K14; BRPF3 is required for H3K14ac at selected replication origins and for efficient origin activation (CDC45 recruitment), but CDC45 recruitment—not MCM2-7 loading—is impaired in BRPF3-depleted cells. RNAi screen, Co-immunoprecipitation, in vitro HAT assay, ChIP-seq, DNA fiber assay The EMBO journal High 26620551
2015 BRPF3 preferentially and specifically forms a tetrameric complex with HBO1 but not with related MYST acetyltransferases (MOZ, MORF, TIP60, MOF). Co-immunoprecipitation of endogenous proteins, affinity purification The Journal of biological chemistry Medium 26677226
2015 HBO1 is degraded after UV-induced DNA damage: ATM/ATR-dependent phosphorylation of Ser-50 and Ser-53 allows HBO1 to interact with DDB2 and be ubiquitylated by CRL4(DDB2); Ser50/53Ala mutants maintain H3K14ac and impair cell cycle regulation in response to UV. In vivo phosphorylation assay, co-immunoprecipitation, ubiquitination assay, phospho-mutagenesis, cell cycle analysis Molecular and cellular biology High 26572825
2016 KAT7 interacts with CENP-A assembly factor M18BP1; KAT7 knockout reduces centromeric CENP-A assembly and causes mitotic chromosome misalignment and micronuclei formation; tethering KAT7 to ectopic alphoid DNA removes H3K9me3 and stimulates new CENP-A or H3.3 assembly, antagonizing Suv39h1-mediated heterochromatin invasion. Co-immunoprecipitation, CRISPR/Cas9 knockout, ChIP, tethering assay, mitosis imaging Developmental cell High 27270040
2016 Hbo1 HAT activity is inhibited by HTLV-1 HBZ protein through direct binding; while HBO1 does not acetylate p53, it acts as a coactivator for p53 at the p21/CDKN1A promoter; HBZ binding to HBO1 impairs p53-mediated transcriptional activation. Co-immunoprecipitation, in vitro HAT assay, reporter assay, ChIP Oncotarget Medium 26625199
2016 KAT7 deficiency in T cells leads to near-complete loss of global H3K14ac, which is mechanistically linked to T cell survival defects and failure to develop normal peripheral T cell populations, without affecting TCR repertoire or positive selection. Conditional knockout mouse, global histone modification analysis, flow cytometry, T cell development assays Journal of leukocyte biology High 27733580
2017 Hbo1 has intrinsic ubiquitin E3 ligase activity toward ERα; estradiol-17β inhibits Hbo1's E3 ligase activity for ERα in vitro; hyperactive ERα mutants from metastatic breast cancers are better substrates for Hbo1 ubiquitination. In vitro ubiquitination assay, mutagenesis, Western blot Proceedings of the Japan Academy. Series B Medium 28769019
2017 The crystal structure of the HBO1 MYST domain in complex with the N-terminal region of BRPF2 revealed key residues for the HBO1-BRPF2 interaction; a short N-terminal region of BRPF2 is sufficient to bind HBO1 and potentiate its activity toward H3K14; BRPF2 regulates HBO1 HAT activity toward free H3 and H4 and nucleosomal H3. Crystal structure determination, in vitro HAT assay, mutagenesis, cell biological validation Nucleic acids research High 28334966
2017 Phosphorylated HBO1 at UV-irradiated sites facilitates histone acetylation to promote XPC recruitment, and recruits SNF2H-ACF1 chromatin remodeling complex to cyclobutane pyrimidine dimer sites to enable nucleotide excision repair; HBO1 depletion sensitizes cells to UV but not in XPE, XPC, or XPA cells. siRNA knockdown, ChIP, UV sensitivity assay, epistasis analysis with XP patient-derived cells Nature communications High 28719581
2017 KAT7 (HBO1) mediates intragenic H3K14 and H4 acetylation to regulate RNA polymerase II binding at the VEGFR-2 gene locus in endothelial cells; KAT7 depletion reduces VEGFR-2 expression and disrupts angiogenic potential; KAT7 inhibition in zebrafish disrupts vessel formation, rescued by human KAT7. siRNA knockdown, ChIP-on-chip, microarray, zebrafish rescue experiment The Journal of biological chemistry High 29414790
2018 JADE1 physically links the HBO1 catalytic subunit with its H3-H4 substrate via an N-terminal 21-residue HBO1- and histone-binding domain and a second histone core-binding domain; JADE1 increases the catalytic efficiency of HBO1 H3-H4 acetylation ~5-fold; HBO1 also contains an N-terminal histone-binding domain that contacts H3-H4 independently of JADE1. In vitro HAT assay with recombinant proteins, domain deletion mapping, in vivo JADE1 deletion experiments The Journal of biological chemistry High 29382722
2018 LPS stabilizes HBO1 protein by upregulating USP25, which deubiquitinates HBO1 and suppresses its proteasomal degradation; USP25 co-immunoprecipitates with HBO1; stabilized HBO1 modulates inflammatory gene transcription. Co-immunoprecipitation, ubiquitination assay, siRNA knockdown, Western blot Biochimica et biophysica acta. Gene regulatory mechanisms Medium 30745998
2019 LYAR recruits BRD2 to rDNA via upstream binding factor; BRD2 is required to recruit KAT7 to rDNA loci, resulting in enhanced H4 acetylation; separately, LYAR-BRD4-KAT7 complex is recruited to rDNA to acetylate both H4 and H3, increasing rRNA synthesis. Co-immunoprecipitation, ChIP, siRNA knockdown, rRNA synthesis assay Nucleic acids research Medium 31504794
2019 HBO1 is a required acetyltransferase for H3K14ac in leukemia stem cells (LSCs); H3K14ac facilitates RNA polymerase II processivity to maintain high expression of HOXA9/HOXA10; a potent HBO1 inhibitor (WM-3835) competes with acetyl-CoA and shows efficacy in AML; CRISPR domain screening identified the HAT domain of HBO1 as essential. shRNA screen, CRISPR domain screening, quantitative mass spectrometry, ChIP-seq, small-molecule inhibition (competitive assay), primary patient AML samples Nature High 31827282
2019 UHRF1 interacts with methylated H3K14 and suppresses H3K14 acetylation by KAT7, thereby repressing TUSC3 transcription in colon cancer cells to promote proliferation. Co-immunoprecipitation, ChIP, siRNA knockdown, histone modification analysis Oncogene Medium 31582837
2020 HBO1 (KAT7) knockout in human cells (293T, MCF7, HeLa) abolishes H3K14ac but does not significantly affect H4 acetylation or DNA replication; loss of HBO1 and H3K14ac leads to secondary loss of almost all H4 acetylation after 4 weeks; HBO1 loss principally affects cell adhesion genes. CRISPR/Cas9 knockout, siRNA knockdown, global histone modification analysis, transcriptomics, proliferation assay Molecular and cellular biology High 31767635
2020 KAT7 loss in MLL-rearranged AML leads to rapid and complete loss of H3K14ac and H4K12ac; KAT7's acetyltransferase activity is essential; mechanistically, acetylated histones serve as a platform for BRD4 and AF4 recruitment to gene promoters, and KAT7 loss dissociates these factors along with RNA Pol II from MLL-fusion target genes (MEIS1, PBX3, SENP6). CRISPR-Cas9 screen and validation, ChIP-seq, RNA-seq, loss-of-function with HAT-dead mutants Leukemia High 32764680
2020 MEAF6 is not essential for HAT activity of Kat7 complexes but modulates the assembly of Kat7 complexes: in the absence of Meaf6, Myst2/Kat7 shows increased ability to interact with PHD-finger proteins (BRPF/JADE). Inducible Meaf6 knockout ES cells, co-immunoprecipitation, histone modification analysis Experimental cell research Medium 32918898
2020 BRPF3 protein is required for Myst2 (KAT7) protein stability; E3 ligase HUWE1 mediates ubiquitin-dependent degradation of Myst2; BRPF3 antagonizes HUWE1-mediated Myst2 degradation through protein-protein interaction. Co-immunoprecipitation, ubiquitination assay, conditional overexpression/knockout of BRPF3 and Huwe1 Cell death and differentiation Medium 32555450
2020 Protein kinase D1 (PKD1) directly interacts with and phosphorylates KAT7 at Thr-97 and Thr-331; phosphorylation by PKD1 enhances KAT7 stability by reducing ubiquitination-mediated degradation; KAT7-Thr97/331A mutant attenuates H4 acetylation, MCM2/6 chromatin loading, DNA replication, and cell proliferation. Co-immunoprecipitation, in vitro kinase assay, phospho-mutagenesis, ubiquitination assay, chromatin fractionation Cell death discovery Medium 33014433
2021 Leukemic MLL fusion proteins associate with the HBO1 HAT complex through their trithorax homology domain 2 (THD2), mainly via ING4/5 and PHF16 subunits in a chromatin-bound, H3K4me3-marked context; MLL-ELL particularly depends on THD2-mediated HBO1 association for leukemic transformation, promoting AEP complex loading over EAF1/p53; NUP98-HBO1 fusion's oncogenicity requires MLL interaction but not intrinsic HAT activity. Co-immunoprecipitation, domain mapping, ChIP, murine hematopoietic progenitor transformation assay eLife High 34431785
2021 HBO1 is a versatile histone acyltransferase that catalyzes not only acetylation but also propionylation, butyrylation, and crotonylation in vivo and in vitro; the minimal HBO1/BRPF2 complex accommodates multiple acyl-CoA substrates; HBO1 is the key enzyme for H3K14 acylations; HBO1 is enriched at TSS of active genes and contributes to bulk histone acylations. In vitro acylation assays with multiple acyl-CoA substrates, mass spectrometry, genome-wide ChIP, CRISPR/Cas9 KO Nucleic acids research High 34259319
2021 HBO1 (KAT7) acetylates histone H3K14 to facilitate RNA polymerase II processivity; CRISPR/Cas9 knockout of HBO1 reduces H3K14ac and gene expression of HOXA9/HOXA10 in leukaemia stem cells. CRISPR/Cas9, ChIP-seq, RNA-seq Nature High 31827282
2022 KAT7 (HBO1) is required for H3K14ac genome-wide in adult hematopoietic stem cells (HSCs); Hbo1 deletion causes rapid loss of HSC quiescence, forces cycling HSCs to produce progenitors at the expense of self-renewal, leading to HSC pool exhaustion and hematopoietic failure; HBO1 maintains expression of genes essential for HSC quiescence (Mpl, Tie-2, Gfi1b, Egr1, Gata2, etc.). Conditional knockout mouse (Mx1-Cre and Rosa26-CreERT2), competitive transplantation, flow cytometry, ChIP-seq, RNA-seq Blood High 34724565
2022 SIRT1 deacetylates and activates KAT7 (H4K12ac activity) in a NOTCH1-driven circuit in T-ALL; global acetyl-proteomics upon SIRT1 loss revealed hyperacetylation of KAT7 (and BRD1); SIRT1 loss reduces H4K12ac; a non-acetylatable KAT7 mutant partly rescues SIRT1 loss-induced proliferation defects. Acetyl-proteomics, SIRT1 genetic ablation/pharmacological inhibition, non-acetylatable KAT7 mutant rescue, ChIP Blood cancer discovery High 36322781
2022 KAT7 is required for optimal expansion of medullary thymic epithelial cells (mTECs) and for AIRE-dependent peripheral tissue gene (PTG) expression, associated with enhanced chromatin accessibility at PTG loci; TEC-specific Kat7 deletion causes organ-specific autoimmunity resembling Aire-deficient mice. Conditional TEC-specific knockout mouse, ATAC-seq (chromatin accessibility), RNA-seq, ChIP, flow cytometry Science immunology High 35061506
2022 KAT7 mediates K525 crotonylation of calnexin (CANX); leucine deprivation promotes CANX K525 crotonylation by KAT7; KAT7 knockout renders MTORC1 insensitive to leucine deprivation; CANX crotonylation is required for its lysosomal translocation and MTORC1 regulation. Cell-free system reconstitution, co-immunoprecipitation, KAT7 knockout, crotonylation-specific antibody, MTORC1 activity assay Autophagy Medium 35266843
2022 HBO1 catalyzes lysine benzoylation (Kbz) in mammalian cells; 1747 Kbz sites were identified in the benzoylome and at least 77 are targeted by HBO1; HBO1-targeted Kbz substrates are involved in chromatin remodeling and transcription regulation. In vitro benzoylation assay, mass spectrometry-based proteomics, CRISPR/Cas9 knockout iScience Medium 36388951
2023 KAT7 and H3K14ac are present at both transcribed and inactive genes genome-wide in neural stem cells; KAT7/H3K14ac are not required for continued transcription of already-active genes but are indispensable for de novo activation of repressed genes; KAT7 deletion abrogates neural stem cell plasticity and differentiation. Conditional KAT7 knockout, ChIP-seq, RNA-seq, neural stem cell differentiation assay, re-expression rescue Cell reports High 36641753
2023 KAT7 interacts with SMAD4 and co-occupies H3K14ac- and H3K4me3-marked open chromatin in hESCs; HBO1 deficiency prevents TGF-β signaling-dependent pluripotency maintenance and causes neuroectoderm differentiation; HBO1/SMAD4 co-bind mesoderm genes in BMP4-triggered differentiation. Co-immunoprecipitation, ChIP-seq, CRISPR/Cas9 knockout, embryoid body/gastruloid/teratoma assay Nucleic acids research High 38421638
2023 HBO1 functions as an acetoacetyltransferase: it catalyzes lysine acetoacetylation (Kacac) of histones in vitro and intracellularly; 33 Kacac sites were identified on mammalian histones. In vitro acetoacetyltransferase assay, HPLC co-elution, MS/MS analysis, Western blot, isotopic labeling Advanced science Medium 37382194
2023 NLRP11 binds to vimentin and KAT7, bridges KAT7 to vimentin, and induces cytoplasmic localization of KAT7; KAT7 directly mediates acetylation of vimentin at Lys104, promoting EMT and malignant behavior in lung adenocarcinoma. Co-immunoprecipitation, in vitro acetylation assay, site-specific mutant, confocal localization, CRISPR/Cas9 KO Advanced science Medium 37424170
2024 The PZP (PHD1-zinc-knuckle-PHD2) domain of JADE subunit engages the nucleosome by binding histone H3 and DNA, directing the HBO1 complex to chromatin; recognition of unmethylated H3K4 by PZP promotes H4 acetylation, whereas H3K4 hypermethylation alters substrate selectivity; structural and genomic data support this mechanism. Crystal/cryo-EM structure of PZP-nucleosome complex, ChIP-seq, complex assembly assays in vivo, functional leukemogenesis assay Nature structural & molecular biology High 38448574
2024 HBO1 functions as a lysine lactyltransferase: it catalyzes lysine lactylation (Kla) in vitro and intracellularly; E508 is a key residue for lactyltransferase activity; HBO1 preferentially catalyzes histone H3K9la; scaffold proteins JADE1 and BRPF2 promote enzymatic activity for histone Kla; HBO1 is required for H3K9la at transcription start sites. In vitro lactyltransferase assay, site-specific mutagenesis (E508), quantitative proteomics, CUT&Tag, HBO1-KO cells Nature communications High 38670996
2024 KAT7 enhances LDHA activity and upregulates LDHA protein expression by acetylating LDHA at lysine 118, promoting the Warburg effect and tumor progression in head and neck squamous carcinoma. Co-immunoprecipitation, site-specific acetylation assay, mutagenesis, LDHA activity assay, CRISPR/Cas9 KO Cancer letters Medium 38593918
2025 KAT7 crotonylation at K432 (facilitated by hMOF) competitively antagonizes its acetylation (regulated by HDAC2) at the same residue upon DNA damage; this competition diminishes HBO1's histone acetyltransferase activity, decreasing H3K14ac at procentriole formation gene promoters and inhibiting procentriole formation. Site-specific mutagenesis, co-immunoprecipitation, in vitro HAT assay, ChIP-qPCR, mass spectrometry Nature communications High 40064919
2025 KAT7 (and KAT6A) associate with NUP98 fusion oncoproteins on chromatin and within condensates via BRPF1; KAT6A/7 inhibition decreases H3K23ac, displaces NUP98::HOXA9 from chromatin, and induces myeloid differentiation; combined KAT6A/7 inhibition shows efficacy in NUP98-rearranged leukemia xenografts and synergizes with menin inhibition. Co-immunoprecipitation/proximity labeling, ChIP-seq, CRISPR knockout, pharmacological inhibition, xenograft mouse model Cancer discovery High 40536430
2025 NgBR deficiency suppresses KAT7 expression, which impairs KAT7-mediated acetylation of the transcriptional repressor RFX1; reduced RFX1 acetylation stabilizes RFX1 by blocking proteasomal degradation, thereby suppressing FGF1 transcription and neuronal survival via PI3K/AKT pathway. RNA sequencing, siRNA knockdown of KAT7, co-immunoprecipitation, acetylation assay, PI3K/AKT activity assay Cellular and molecular life sciences Medium 40192836

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1999 Histone acetyltransferase HBO1 interacts with the ORC1 subunit of the human initiator protein. The Journal of biological chemistry 263 10438470
2010 HBO1 histone acetylase activity is essential for DNA replication licensing and inhibited by Geminin. Molecular cell 202 20129055
2011 The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis. Blood 172 21753189
2006 Regulation of replication licensing by acetyltransferase Hbo1. Molecular and cellular biology 162 16428461
2001 Replication factors MCM2 and ORC1 interact with the histone acetyltransferase HBO1. The Journal of biological chemistry 162 11278932
2024 HBO1 catalyzes lysine lactylation and mediates histone H3K9la to regulate gene transcription. Nature communications 161 38670996
2009 HBO1 HAT complexes target chromatin throughout gene coding regions via multiple PHD finger interactions with histone H3 tail. Molecular cell 158 19187766
2010 HBO1 is required for H3K14 acetylation and normal transcriptional activity during embryonic development. Molecular and cellular biology 147 21149574
2008 HBO1 histone acetylase is a coactivator of the replication licensing factor Cdt1. Genes & development 147 18832067
2019 HBO1 is required for the maintenance of leukaemia stem cells. Nature 146 31827282
2020 CircMRPS35 suppresses gastric cancer progression via recruiting KAT7 to govern histone modification. Molecular cancer 144 32164722
2015 BRPF3-HBO1 regulates replication origin activation and histone H3K14 acetylation. The EMBO journal 113 26620551
2000 Androgen receptor interacts with a novel MYST protein, HBO1. The Journal of biological chemistry 109 10930412
2011 Conserved molecular interactions within the HBO1 acetyltransferase complexes regulate cell proliferation. Molecular and cellular biology 82 22144582
2016 KAT7/HBO1/MYST2 Regulates CENP-A Chromatin Assembly by Antagonizing Suv39h1-Mediated Centromere Inactivation. Developmental cell 79 27270040
2008 Role for Plk1 phosphorylation of Hbo1 in regulation of replication licensing. Proceedings of the National Academy of Sciences of the United States of America 79 18250300
2009 Histone acetyltransferase Hbo1: catalytic activity, cellular abundance, and links to primary cancers. Gene 76 19393168
2012 Plk1 phosphorylation of orc2 and hbo1 contributes to gemcitabine resistance in pancreatic cancer. Molecular cancer therapeutics 70 23188630
2021 The histone acetyltransferase HBO1 functions as a novel oncogenic gene in osteosarcoma. Theranostics 69 33754016
2021 HBO1 is a versatile histone acyltransferase critical for promoter histone acylations. Nucleic acids research 68 34259319
2008 Role of Jade-1 in the histone acetyltransferase (HAT) HBO1 complex. The Journal of biological chemistry 65 18684714
2022 The histone lysine acetyltransferase HBO1 (KAT7) regulates hematopoietic stem cell quiescence and self-renewal. Blood 58 34724565
2010 Chromatin unfolding by Cdt1 regulates MCM loading via opposing functions of HBO1 and HDAC11-geminin. Cell cycle (Georgetown, Tex.) 57 20980834
2006 Ligand-controlled interaction of histone acetyltransferase binding to ORC-1 (HBO1) with the N-terminal transactivating domain of progesterone receptor induces steroid receptor coactivator 1-dependent coactivation of transcription. Molecular endocrinology (Baltimore, Md.) 54 16645042
2007 Hbo1 Links p53-dependent stress signaling to DNA replication licensing. Molecular and cellular biology 52 17954561
2007 FAD24 acts in concert with histone acetyltransferase HBO1 to promote adipogenesis by controlling DNA replication. The Journal of biological chemistry 50 18029353
2012 Histone acetyl transferase (HAT) HBO1 and JADE1 in epithelial cell regeneration. The American journal of pathology 45 23159946
2018 Histone acetyltransferase 7 (KAT7)-dependent intragenic histone acetylation regulates endothelial cell gene regulation. The Journal of biological chemistry 44 29414790
2017 HBO1 promotes cell proliferation in bladder cancer via activation of Wnt/β-catenin signaling. Molecular carcinogenesis 44 28796367
2021 Circular RNA Foxo3 Relieves Myocardial Ischemia/Reperfusion Injury by Suppressing Autophagy via Inhibiting HMGB1 by Repressing KAT7 in Myocardial Infarction. Journal of inflammation research 43 34880642
2020 KAT7 is a genetic vulnerability of acute myeloid leukemias driven by MLL rearrangements. Leukemia 43 32764680
2019 Deciphering structure, function and mechanism of lysine acetyltransferase HBO1 in protein acetylation, transcription regulation, DNA replication and its oncogenic properties in cancer. Cellular and molecular life sciences : CMLS 43 31535175
2016 Human T-cell leukemia virus type-1-encoded protein HBZ represses p53 function by inhibiting the acetyltransferase activity of p300/CBP and HBO1. Oncotarget 41 26625199
2013 Hbo1 is a cyclin E/CDK2 substrate that enriches breast cancer stem-like cells. Cancer research 41 23955388
2011 JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress. Molecular cell 41 21856198
2017 Phosphorylated HBO1 at UV irradiated sites is essential for nucleotide excision repair. Nature communications 38 28719581
2013 SCF(Fbxw15) mediates histone acetyltransferase binding to origin recognition complex (HBO1) ubiquitin-proteasomal degradation to regulate cell proliferation. The Journal of biological chemistry 38 23319590
2010 The dimeric structure and the bivalent recognition of H3K4me3 by the tumor suppressor ING4 suggests a mechanism for enhanced targeting of the HBO1 complex to chromatin. Journal of molecular biology 35 20053357
2019 HBO1 directs histone H4 specific acetylation, potentiating mechano-transduction pathways and membrane elasticity in ovarian cancer cells. Nanomedicine : nanotechnology, biology, and medicine 34 30759370
2015 The Chromatin Regulator BRPF3 Preferentially Activates the HBO1 Acetyltransferase but Is Dispensable for Mouse Development and Survival. The Journal of biological chemistry 34 26677226
2016 Essential role for the histone acetyltransferase KAT7 in T cell development, fitness, and survival. Journal of leukocyte biology 32 27733580
2015 UV Damage-Induced Phosphorylation of HBO1 Triggers CRL4DDB2-Mediated Degradation To Regulate Cell Proliferation. Molecular and cellular biology 32 26572825
2019 UHRF1-KAT7-mediated regulation of TUSC3 expression via histone methylation/acetylation is critical for the proliferation of colon cancer cells. Oncogene 31 31582837
2013 Histone acetyltransferase Hbo1 destabilizes estrogen receptor α by ubiquitination and modulates proliferation of breast cancers. Cancer science 30 24125069
2023 Stem cell plasticity, acetylation of H3K14, and de novo gene activation rely on KAT7. Cell reports 29 36641753
2020 HBO1 (KAT7) Does Not Have an Essential Role in Cell Proliferation, DNA Replication, or Histone 4 Acetylation in Human Cells. Molecular and cellular biology 29 31767635
2019 LYAR potentiates rRNA synthesis by recruiting BRD2/4 and the MYST-type acetyltransferase KAT7 to rDNA. Nucleic acids research 29 31504794
2017 Structural and mechanistic insights into regulation of HBO1 histone acetyltransferase activity by BRPF2. Nucleic acids research 29 28334966
2020 NCAPG2 facilitates glioblastoma cells' malignancy and xenograft tumor growth via HBO1 activation by phosphorylation. Cell and tissue research 28 32897418
2018 The scaffolding protein JADE1 physically links the acetyltransferase subunit HBO1 with its histone H3-H4 substrate. The Journal of biological chemistry 28 29382722
2023 Identification of Histone Lysine Acetoacetylation as a Dynamic Post-Translational Modification Regulated by HBO1. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 27 37382194
2023 Histone acetylation by HBO1 (KAT7) activates Wnt/β-catenin signaling to promote leukemogenesis in B-cell acute lymphoblastic leukemia. Cell death & disease 27 37542030
2015 The histone acetyltransferase Myst2 regulates Nanog expression, and is involved in maintaining pluripotency and self-renewal of embryonic stem cells. FEBS letters 27 25743411
2020 The Protective Effect of HBO1 on Cigarette Smoke Extract-Induced Apoptosis in Airway Epithelial Cells. International journal of chronic obstructive pulmonary disease 26 32021140
2021 HBO1 overexpression is important for hepatocellular carcinoma cell growth. Cell death & disease 25 34039960
2023 A first-in-class HBO1 inhibitor WM-3835 inhibits castration-resistant prostate cancer cell growth in vitro and in vivo. Cell death & disease 24 36709328
2022 HBO1 induces histone acetylation and is important for non-small cell lung cancer cell growth. International journal of biological sciences 24 35637972
2022 HBO1 catalyzes lysine benzoylation in mammalian cells. iScience 24 36388951
2021 HBO1-MLL interaction promotes AF4/ENL/P-TEFb-mediated leukemogenesis. eLife 23 34431785
2018 LPS promotes HBO1 stability via USP25 to modulate inflammatory gene transcription in THP-1 cells. Biochimica et biophysica acta. Gene regulatory mechanisms 23 30745998
2006 Histone acetyltransferase HBO1 inhibits NF-kappaB activity by coactivator sequestration. Biochemical and biophysical research communications 23 16997280
2015 MYST2 acetyltransferase expression and Histone H4 Lysine acetylation are suppressed in AML. Experimental hematology 22 26072331
2014 Cell cycle-dependent chromatin shuttling of HBO1-JADE1 histone acetyl transferase (HAT) complex. Cell cycle (Georgetown, Tex.) 22 24739512
2023 Circ-myh8 Promotes Pulmonary Hypertension by Recruiting KAT7 to Govern Hypoxia-Inducible Factor-1α Expression. Journal of the American Heart Association 21 36942752
2023 The NLRP11 Protein Bridges the Histone Lysine Acetyltransferase KAT7 to Acetylate Vimentin in the Early Stage of Lung Adenocarcinoma. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 19 37424170
2022 KAT7-mediated CANX (calnexin) crotonylation regulates leucine-stimulated MTORC1 activity. Autophagy 19 35266843
2019 A novel long non-coding RNA-KAT7 is low expressed in colorectal cancer and acts as a tumor suppressor. Cancer cell international 19 30858757
2019 NUP98-HBO1-fusion generates phenotypically and genetically relevant chronic myelomonocytic leukemia pathogenesis. Blood advances 19 30944097
2005 Cyclin-dependent kinase 11(p58) interacts with HBO1 and enhances its histone acetyltransferase activity. FEBS letters 19 15963510
2019 HBOA ameliorates CCl4-incuded liver fibrosis through inhibiting TGF-β1/Smads, NF-κB and ERK signaling pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 18 31079002
2017 Intrinsic ubiquitin E3 ligase activity of histone acetyltransferase Hbo1 for estrogen receptor α. Proceedings of the Japan Academy. Series B, Physical and biological sciences 16 28769019
2010 Estrogen receptor α (ERα) mediates 17β-estradiol (E2)-activated expression of HBO1. Journal of experimental & clinical cancer research : CR 15 21040551
2022 The acetyltransferase KAT7 is required for thymic epithelial cell expansion, expression of AIRE target genes, and thymic tolerance. Science immunology 14 35061506
2020 MicroRNA-639 is Down-Regulated in Hepatocellular Carcinoma Tumor Tissue and Inhibits Proliferation and Migration of Human Hepatocellular Carcinoma Cells Through the KAT7/Wnt/β-Catenin Pathway. Medical science monitor : international medical journal of experimental and clinical research 14 31955177
2017 Upregulated KAT7 in synovial fibroblasts promotes Th17 cell differentiation and infiltration in rheumatoid arthritis. Biochemical and biophysical research communications 14 28552525
2020 BRPF3-HUWE1-mediated regulation of MYST2 is required for differentiation and cell-cycle progression in embryonic stem cells. Cell death and differentiation 13 32555450
2020 Protein kinase D1 phosphorylation of KAT7 enhances its protein stability and promotes replication licensing and cell proliferation. Cell death discovery 13 33014433
2017 Myst2/Kat7 histone acetyltransferase interaction proteomics reveals tumour-suppressor Niam as a novel binding partner in embryonic stem cells. Scientific reports 13 28811661
2013 Expression and characterization of androgen receptor coregulators, SRC-2 and HBO1, during human testis ontogenesis and in androgen signaling deficient patients. Molecular and cellular endocrinology 13 23707616
2025 KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in NUP98-Rearranged Acute Myeloid Leukemia. Cancer discovery 12 40536430
2024 Spermidine metabolism regulates leukemia stem and progenitor cell function through KAT7 expression in patient-derived mouse models. Science translational medicine 12 39321266
2023 KAT7 promotes radioresistance through upregulating PI3K/AKT signaling in breast cancer. Journal of radiation research 12 36724120
2023 The lncRNA ADAMTS9-AS1/miR-185-5p/KAT7 ceRNA network inhibits cardiomyocyte hypertrophy in hypertrophic obstructive cardiomyopathy. Biomedical research (Tokyo, Japan) 12 37258203
2024 Guiding the HBO1 complex function through the JADE subunit. Nature structural & molecular biology 11 38448574
2010 Histone acetylation by HBO1 tightens replication licensing. Molecular cell 11 20129050
2024 KAT7 enhances the proliferation and metastasis of head and neck squamous carcinoma by promoting the acetylation level of LDHA. Cancer letters 10 38593918
2023 A Therapeutically Targetable NOTCH1-SIRT1-KAT7 Axis in T-cell Leukemia. Blood cancer discovery 10 36322781
2025 Competitive antagonism of KAT7 crotonylation against acetylation affects procentriole formation and colorectal tumorigenesis. Nature communications 9 40064919
2024 Multifunctional acyltransferase HBO1: a key regulatory factor for cellular functions. Cellular & molecular biology letters 9 39543485
2025 Targeting KAT7 inhibits the progression of colorectal cancer. Theranostics 8 39816686
2023 The circular RNA Rap1b promotes Hoxa5 transcription by recruiting Kat7 and leading to increased Fam3a expression, which inhibits neuronal apoptosis in acute ischemic stroke. Neural regeneration research 8 37056143
2021 The histone acetyltransferase HBO1 promotes efficient tip cell sprouting during angiogenesis. Development (Cambridge, England) 8 34550360
2020 LncRNA-KAT7 Negatively Regulates miR-10a Through an Epigenetic Pathway to Participate in Nonsmall Cell Lung Cancer. Cancer biotherapy & radiopharmaceuticals 8 32423237
2024 HBO1, a MYSTerious KAT and its links to cancer. Biochimica et biophysica acta. Gene regulatory mechanisms 7 38851533
2022 HBO1 as an Important Target for the Treatment of CCL4-Induced Liver Fibrosis and Aged-Related Liver Aging and Fibrosis. Oxidative medicine and cellular longevity 7 36524217
2016 Functional analysis of HBO1 in tumor development and inhibitor screening. International journal of molecular medicine 7 27247147
2001 Studies on the biosynthesis of 2-hydroxy-1,4-benzoxazin-3-one (HBOA) from 3-hydroxyindolin-2-one in Zea mays. Phytochemistry 7 11393516
2025 Loss of NgBR causes neuronal damage through decreasing KAT7-mediated RFX1 acetylation and FGF1 expression. Cellular and molecular life sciences : CMLS 6 40192836
2024 HBO1 determines SMAD action in pluripotency and mesendoderm specification. Nucleic acids research 6 38421638
2020 MEAF6 is essential for cell proliferation and plays a role in the assembly of KAT7 complexes. Experimental cell research 6 32918898