Affinage

INO80C

INO80 complex subunit C · UniProt Q6PI98

Length
192 aa
Mass
20.6 kDa
Annotated
2026-06-10
46 papers in source corpus 20 papers cited in narrative 20 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

INO80C (Ies6/hIes6) is a conserved core subunit of the INO80 ATP-dependent chromatin-remodeling complex that, together with Arp5, forms a structural module governing how the complex engages and remodels nucleosomes (PMID:29643509, PMID:21303910). Cryo-EM of fungal and human INO80 bound to a nucleosome places the Arp5-Ies6 module at superhelical locations -2/-3 on the face opposite the Snf2 ATPase motor, where it acts as a counter grip against which the motor pumps entry DNA into the nucleosome (PMID:29643509, PMID:29643506). Functionally, Arp5/Ies6 promotes binding of the Ino80 ATPase to nucleosomes and couples ATP hydrolysis to productive translocation, while the partner subunit Ies2 activates intrinsic catalysis; an Arp5 insertion domain is specifically required to convert hydrolysis into nucleosome sliding (PMID:24297934, PMID:26306040, PMID:27257055). Through these activities INO80C is essential for genome-wide nucleosome spacing and regular array organization, acting redundantly with the ISWI remodeler Isw2 (PMID:41720950). The module supports the complex's broader genome-maintenance roles: it removes/prevents H2A.Z misincorporation at pericentric chromatin to ensure proper chromosome segregation (PMID:23207916), promotes homologous recombination by H2A.Z-dependent presynaptic filament formation and by recruiting ubiquitin-conjugating factors that deplete histones at damage (PMID:28514650, PMID:33529595), protects replication origins by limiting pervasive transcription and enabling fork restart under replication stress (PMID:26798134, PMID:32905765), and regulates metabolic gene expression and mitochondrial homeostasis (PMID:26755556, PMID:29462149). ACTR5/IES6 additionally support hepatocellular carcinoma proliferation through CDK/E2F-driven cell-cycle signaling (PMID:36563143).

Mechanistic history

Synthesis pass · year-by-year structured walk · 15 steps
  1. 2009 Medium

    Establishing that Ies6 is a functional INO80 subunit required showing its loss phenocopies other complex members; deletion in fission yeast produced DNA repair, replication-stress, and nucleotide-metabolism defects and the Ies6-containing complex remodeled nucleosomes in vitro.

    Evidence Genetic deletion with damage-sensitivity assays and in vitro remodeling in S. pombe

    PMID:19933844

    Open questions at the time
    • Did not resolve Ies6's specific molecular contribution within the complex
    • No structural placement of the subunit
  2. 2011 High

    Module organization of human INO80 was defined, assigning Ies6 to the conserved catalytic core module built on the Snf2 ATPase domain alongside Arp5, Tip49a/b, and Ies2.

    Evidence Subcomplex purification and reconstitution with ATPase and remodeling assays

    PMID:21303910

    Open questions at the time
    • Did not separate Ies6's role from Arp5 within the module
    • No structural detail of nucleosome contacts
  3. 2012 High

    Loss-of-function showed Ies6 is critical for preventing H2A.Z misincorporation at centromeres, linking the subunit to faithful chromosome segregation.

    Evidence Genetic deletion, flow-cytometry ploidy, ChIP, and live-cell segregation imaging in budding yeast

    PMID:23207916

    Open questions at the time
    • Mechanism of H2A.Z eviction specificity not resolved
    • Did not address pericentric remodeling biochemistry
  4. 2013 High

    Dissecting subunit roles revealed Ies6 and Arp5 govern substrate recognition (nucleosome binding by the ATPase) while Ies2 drives intrinsic catalysis, separating substrate engagement from hydrolysis.

    Evidence Biochemical reconstitution with ATPase and nucleosome-binding assays using purified subcomplexes

    PMID:24297934

    Open questions at the time
    • How binding is coupled to remodeling output not yet shown
    • No structural basis for the binding contribution
  5. 2015 High

    Two studies established that the Ies6/Arp5 module is essential for remodeling and that the Arp5 insertion domain couples ATP hydrolysis to translocation, defining where coupling is encoded.

    Evidence EM/MS architecture plus domain-deletion mutagenesis with Co-IP, ChIP, and ATPase/sliding assays

    PMID:25964121 PMID:26306040

    Open questions at the time
    • Atomic-resolution view of the coupling mechanism still lacking
    • Assembly determinants in Ino80 spacer only partially mapped
  6. 2016 High

    In vivo and recombinant work showed Arp5-Ies6 forms a distinct subcomplex that stimulates ATP hydrolysis and sliding, with Ies2 acting synergistically/antagonistically and IP6 inhibiting hydrolysis, while genomic occupancy linked the module to TSS nucleosome positioning and metabolic gene expression.

    Evidence Co-IP, recombinant minimal complex biochemistry, inhibitor and mutagenesis studies, ChIP-seq, and expression analysis

    PMID:26755556 PMID:27257055

    Open questions at the time
    • Direct causal link between spacing and the metabolic transcriptional program not established
    • Physiological role of IP6 regulation unclear
  7. 2017 Medium

    Genetic epistasis assigned INO80-C a discrete HR step: it facilitates presynaptic filament formation by removing H2A.Z, since H2A.Z loss rescues HR in INO80-C-deficient mutants.

    Evidence Double-mutant analysis, microscopy of repair intermediates, and HR frequency assays in yeast

    PMID:28514650

    Open questions at the time
    • Ies6-specific contribution within INO80-C not isolated
    • Biochemical reconstitution of the filament-promoting step absent
  8. 2018 High

    Parallel cryo-EM structures of fungal and human INO80-nucleosome complexes provided the atomic framework, placing Arp5-Ies6 as a counter grip at SHL -2/-3 opposite the motor and revealing H3-tail-dependent regulation of the motor through this arrangement.

    Evidence High-resolution cryo-EM with biochemical regulation assays of C. thermophilum and human INO80

    PMID:29643506 PMID:29643509

    Open questions at the time
    • Dynamic conformational cycle during translocation not fully captured
    • Ies6 fold and contacts resolved only at module resolution
  9. 2018 Medium

    Genetic-interaction and signaling studies tied the Ies6 module to metabolic homeostasis, mitochondrial maintenance, and TORC1-to-chromatin signaling, broadening INO80C's physiological role beyond remodeling biochemistry.

    Evidence Genetic interaction screen with expression and histone-modification analyses in yeast

    PMID:29462149

    Open questions at the time
    • Direct chromatin target of TORC1-INO80 signaling not pinpointed
    • Mechanism connecting mitochondrial state to Ies6 unresolved
  10. 2018 Low

    A candidate physical link between human INO80-C and the acetyltransferase P300 raised the possibility of coordinated chromatin-accessibility control at INO80 targets.

    Evidence Co-IP and INO80-subunit ChIP-seq

    PMID:29432129

    Open questions at the time
    • Single Co-IP without reciprocal validation or functional follow-up
    • Direct Ies6 involvement in the interaction not demonstrated
  11. 2021 Medium

    INO80C was shown to drive histone depletion at damaged chromatin by recruiting ubiquitin-conjugating factors, mechanistically connecting remodeling to chromatin decompaction and enhanced repair-locus mobility.

    Evidence Chromatin-associated proteomics, genetic epistasis, live-cell imaging, and strand-invasion assays

    PMID:33529595

    Open questions at the time
    • How INO80C recruits the ubiquitin factors not defined
    • Ies6-specific requirement not separated from whole-complex activity
  12. 2022 Medium

    CRISPR tiling revealed an ACTR5/IES6 functional signature distinct from other INO80 members in hepatocellular carcinoma, suggesting a partly INO80-independent role in supporting CDK/E2F-driven proliferation.

    Evidence CRISPR interference and tiling screens with expression analysis and xenograft assays

    PMID:36563143

    Open questions at the time
    • Molecular basis of the proposed INO80-independent activity unknown
    • Direct IES6 effector for CDKN2A/E2F control not identified
  13. 2023 Medium

    Damaged-DNA biochemistry showed INO80-C translocation is abolished by abasic and UV lesions via impaired Ino80 ATP hydrolysis, while INO80-C separately stimulates APE1 cleavage of AP sites independently of translocation.

    Evidence In vitro DNA translocation, ATPase on damaged substrates, AP-site cleavage, and nucleosome-binding assays

    PMID:37696438

    Open questions at the time
    • No mutagenesis confirming the active-site basis of lesion sensing
    • Ies6-specific contribution within the complex not tested
  14. 2024 Medium

    Nuclear actin levels, set by cytoplasmic actin dynamics, were shown to stimulate INO80C activity, with INO80C ablation conferring partial resistance to chromosome shattering by limiting conversion of single-strand lesions to DSBs.

    Evidence Phosphoproteomics, auxin-induced degradation, genetic ablation, and nuclear actin quantification in yeast

    PMID:39548059

    Open questions at the time
    • Direct biochemical link between G-actin levels and Ies6 module activity not reconstituted
    • How remodeling increases polymerase processivity unclear
  15. 2026 Medium

    Genome-wide mapping established that Ies6 is required for proper nucleosome spacing and array regularity, acting redundantly with the ISWI remodeler Isw2, and that this organizing role is predicted by INO80 binding rather than by transcriptional output.

    Evidence MNase-seq nucleosome mapping, synthetic-lethality genetics, and ChIP-seq in yeast

    PMID:41720950

    Open questions at the time
    • Mechanism of redundancy with Isw2 not defined
    • Decoupling of spacing from expression not mechanistically explained

Open questions

Synthesis pass · forward-looking unresolved questions
  • Whether the candidate INO80C-independent and human-specific roles (e.g., P300 interaction, ACTR5/IES6 in cancer proliferation) reflect distinct molecular activities of Ies6 separate from its structural counter-grip function within INO80 remains unresolved.
  • No reconstituted INO80-independent activity demonstrated
  • Human-specific effector pathways for IES6 not mapped
  • Ies6 isolated contribution distinct from Arp5 not established in vivo

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 3 GO:0140096 catalytic activity, acting on a protein 3 GO:0140657 ATP-dependent activity 3
Localization
GO:0005634 nucleus 3 GO:0000228 nuclear chromosome 2
Pathway
R-HSA-4839726 Chromatin organization 4 R-HSA-73894 DNA Repair 4 R-HSA-1640170 Cell Cycle 2 R-HSA-69306 DNA Replication 2
Partners
ACTR5ARP4EP300IES2INO80RUVBL1RUVBL2
Complex memberships
Arp5-Ies6 moduleINO80 chromatin remodeling complex

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2018 Cryo-EM structure of the evolutionarily conserved INO80 core complex from Chaetomium thermophilum bound to a nucleosome at 4.3 Å (major parts at 3.7 Å) revealed that Arp5 and Ies6 (INO80C) bind superhelical locations -2 and -3 to act as a counter grip for the ATPase motor on the opposite side of the H2A-H2B dimer. The Arp5 insertion domain forms a grappler element that contacts the nucleosome dyad and packs against histone H2A-H2B near the acidic patch, while the ATPase motor pumps entry DNA into the nucleosome against this Arp5-Ies6 grip. Cryo-EM structure determination; biochemical assays Nature High 29643509
2018 Cryo-EM structure of the human INO80 complex bound to a nucleosome showed that the ARP5-IES6 (INO80C) module makes contacts on the opposite face of the nucleosome from the motor domains, and that histone H3 tails (rather than H4 tails as in other remodelers) regulate INO80 motor domain activity in a manner dependent on this ARP5-IES6 arrangement. Cryo-EM structure determination; biochemical regulation assays Nature High 29643506
2011 The human INO80 complex is organized into three modules assembling on distinct domains of hIno80 ATPase. The third module, comprising the hIno80 Snf2 ATPase domain, Ies2, Ies6 (INO80C), Tip49a, Tip49b, and Arp5, is part of the evolutionarily conserved core required for ATP-dependent nucleosome remodeling activity. Subcomplex purification; biochemical reconstitution; ATPase and nucleosome remodeling assays The Journal of biological chemistry High 21303910
2013 In the human INO80 complex, Ies6 (INO80C) and Arp5 function together to promote binding of the Ino80 ATPase to nucleosomes, whereas Ies2 functions as a potent activator of the intrinsic ATPase catalytic activity. Ies6 and Arp5 thus regulate substrate recognition rather than intrinsic catalysis. Biochemical reconstitution; ATPase assays; nucleosome-binding assays with purified subcomplexes Proceedings of the National Academy of Sciences of the United States of America High 24297934
2015 The Ies6/Arp5 module is essential for INO80 complex chromatin remodeling activity in vitro, and controls conformational changes that couple nucleosome binding to remodeling. By contrast, the Arp8/Arp4/Act1 module enhances nucleosome-binding affinity but is largely dispensable for remodeling. EM class averages and mass spectrometry positioned these modules within the overall architecture. Electron microscopy; mass spectrometry; biochemical remodeling assays with defined subunit deletions Nature communications High 25964121
2016 Arp5 and Ies6 (INO80C) form an abundant and distinct subcomplex in vivo in yeast, stimulate INO80-mediated ATP hydrolysis and nucleosome sliding in vitro, and their genomic occupancy correlates with nucleosome positioning at transcriptional start sites and expression levels of >1,000 INO80-regulated genes enriched in energy metabolism pathways. Loss of ies6 leads to decreased glycolytic gene expression and elevated mitochondrial potential. Co-immunoprecipitation; in vitro ATPase and nucleosome sliding assays; genomic ChIP-seq; gene expression analysis Molecular and cellular biology High 26755556
2015 Assembly of the Arp5-Ies6 module with the INO80 complex requires distinct conserved domains within Arp5, Ies6, and the Ino80 spacer region. Ies2 is required for Arp5-Ies6 association with the catalytic components; loss of IES2 or INO80 abolishes Arp5-Ies6 chromatin association. A mutant Arp5 lacking its insertion domains can stimulate ATPase activity but not nucleosome sliding, indicating the insertion domain couples hydrolysis to translocation. Domain deletion mutagenesis; Co-immunoprecipitation; chromatin immunoprecipitation; in vitro ATPase and nucleosome sliding assays The Journal of biological chemistry High 26306040
2016 Using a recombinant minimal human INO80 core complex, Arp5/Ies6 and Ies2 were shown to regulate nucleosome sliding synergistically and antagonistically. Inositol hexaphosphate (IP6) is a non-competitive inhibitor that blocks the stimulatory effect of nucleosomes on ATPase activity, with its binding site in the C-terminal region of Ino80. An Arp5 bypass mutation restores activity in the absence of Ies2, revealing coupling between Ies2 and Arp5/Ies6 in controlling ATP hydrolysis-to-sliding coupling. Recombinant protein reconstitution; ATPase assays; nucleosome sliding assays; inhibitor studies; mutagenesis Nucleic acids research High 27257055
2012 Loss of the Ies6 subunit (INO80C) in budding yeast phenocopies loss of the Ino80 catalytic subunit, causing rapid polyploidy, defective chromosome segregation, and altered pericentric chromatin structure due to misincorporation of H2A.Z into pericentric nucleosomes. Ies6 is thus critical for INO80 function in preventing H2A.Z misincorporation at centromeres. Genetic deletion; flow cytometry (ploidy measurement); chromatin immunoprecipitation; live-cell imaging of chromosome segregation Genes & development High 23207916
2009 In fission yeast, deletion of ies6 causes defects in DNA damage repair, response to replication stress, and nucleotide metabolism, phenocopying deletion of other INO80 complex subunits. The Ino80 complex from fission yeast containing Ies6 mediates ATP-dependent nucleosome remodeling in vitro. Genetic deletion; DNA damage sensitivity assays; in vitro nucleosome remodeling assays Molecular and cellular biology Medium 19933844
2018 In yeast, the Ies6 subunit module displays a divergent genetic interaction signature that links the INO80 complex to metabolic homeostasis. ies6 mutants show disrupted mitochondrial maintenance, and INO80 (including its Ies6 module) is needed for TORC1-mediated signaling to chromatin, as ino80 mutants exhibit defective transcriptional profiles and altered histone acetylation of TORC1-responsive genes. Genetic interaction screen; gene expression analysis; histone modification assays PLoS genetics Medium 29462149
2022 ACTR5 (Arp5) and its interacting partner IES6 (INO80C) show a distinct, HCC-specific functional signature compared to other INO80 complex members in CRISPR tiling scans, suggesting an INO80-independent mechanism of ACTR5/IES6 in supporting hepatocellular carcinoma cell proliferation. Suppression of ACTR5 activated CDKN2A and ablated CDK/E2F-driven cell cycle signaling. CRISPR interference screen; CRISPR gene tiling scans; gene expression analysis; xenograft tumor assays Science advances Medium 36563143
2017 INO80 complex function in homologous recombination includes at least two distinct steps: DNA end resection and presynaptic filament formation. The second function is linked to H2A.Z: in the absence of H2A.Z, presynaptic filament formation and HR are restored in INO80-C-deficient yeast mutants, indicating that INO80-C facilitates HR by removing H2A.Z to promote filament formation. Genetic epistasis (double mutant analysis); fluorescence microscopy of repair intermediates; HR frequency assays in yeast Cell reports Medium 28514650
2016 In budding yeast, the INO80 complex cooperates with Mec1 (ATR) and PAF1C to remove RNAPII from transcribed genes near early-firing replication origins upon replication stress (hydroxyurea). This removal is required for efficient replication fork restart; failure to evict RNAPII in ino80 mutants correlates with inability to restart stalled forks. Genetic epistasis; ChIP; proteomic analyses; replication fork restart assays Genes & development Medium 26798134
2020 INO80 complex co-localizes with the origin recognition complex (ORC) at yeast replication origins and replication initiation sites in mouse ESCs, preventing pervasive transcription through origin sequences. Genetic studies show that INO80C and Mot1/NC2 function through distinct pathways to limit origin transcription; absence of INO80C leads to formation of new DNA double-strand breaks at origins. ChIP-seq; nascent transcript sequencing; genetic epistasis; DSB detection assays Cell reports Medium 32905765
2021 During DNA damage in yeast, INO80C-dependent recruitment of five ubiquitin-conjugating factors (Rad6, Bre1, Pep5, Ufd4, and Rsp5) contributes to core and linker histone depletion at damaged chromatin, reducing chromatin compaction and enhancing DNA locus mobility and strand invasion kinetics during homology-driven repair. Chromatin-associated proteomics; genetic epistasis; live-cell imaging; strand invasion assays Molecular cell Medium 33529595
2023 Abasic sites and UV-irradiation damage abolish the DNA translocation activity of INO80-C by compromising ATP hydrolysis within the Ino80 catalytic subunit, while nucleosome binding remains unaffected. INO80-C also facilitates cleavage of abasic (AP) sites by AP-endonuclease 1 (APE1) independently of its DNA translocation activity. In vitro DNA translocation assays; ATPase assays with damaged substrates; AP site cleavage assay; nucleosome binding assays The Journal of biological chemistry Medium 37696438
2024 Loss of cytoplasmic actin filaments (via TORC2 inhibition or Las17 degradation) raises nuclear actin levels, which in complex with Arp4 is an essential subunit of INO80C. Genetic ablation of INO80C activity leads to partial resistance to yeast chromosome shattering (YCS), suggesting that elevated nuclear G-actin stimulates INO80C to increase DNA polymerase processivity and thereby converts single-strand lesions into double-strand breaks. Phosphoproteomics; auxin-induced protein degradation; genetic ablation; nuclear actin quantification Nature communications Medium 39548059
2026 Deletion of IES6 in yeast reduces genome-wide nucleosome spacing by 3 bp and disrupts regular nucleosome arrays across most genes. IES6 deletion is synthetically lethal with deletion of ISW2 (an ISWI-family remodeler), indicating functional redundancy in nucleosome organization. INO80 binding directly predicts the role of Ies6 in nucleosome organization, whereas gene expression changes do not correlate with altered spacing. Genome-wide nucleosome mapping (MNase-seq); genetic epistasis (synthetic lethality); ChIP-seq Scientific reports Medium 41720950
2018 In the human INO80 complex, biochemical approaches indicated that INO80-C and the H3K27 acetyltransferase P300 physically interact, suggesting they may jointly coordinate chromatin accessibility at canonical INO80 target sites. Co-immunoprecipitation; ChIP-seq for INO80 subunits G3 (Bethesda, Md.) Low 29432129

Source papers

Stage 0 corpus · 46 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2018 Structural basis for ATP-dependent chromatin remodelling by the INO80 complex. Nature 195 29643509
2018 Structure and regulation of the human INO80-nucleosome complex. Nature 151 29643506
2003 From gene networks to gene function. Genome research 133 14656964
2004 Mutator genes for suppression of gross chromosomal rearrangements identified by a genome-wide screening in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America 126 15184655
2016 Mec1, INO80, and the PAF1 complex cooperate to limit transcription replication conflicts through RNAPII removal during replication stress. Genes & development 101 26798134
2011 Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. The Journal of biological chemistry 100 21303910
2021 PHYTOCHROME-INTERACTING FACTORs trigger environmentally responsive chromatin dynamics in plants. Nature genetics 98 34140685
2017 Genome-Wide CRISPR Screen for Essential Cell Growth Mediators in Mutant KRAS Colorectal Cancers. Cancer research 94 28954733
2016 Scan-associated distress in lung cancer: Quantifying the impact of "scanxiety". Lung cancer (Amsterdam, Netherlands) 82 27597289
2017 The INO80 Complex Removes H2A.Z to Promote Presynaptic Filament Formation during Homologous Recombination. Cell reports 63 28514650
2015 Structural analyses of the chromatin remodelling enzymes INO80-C and SWR-C. Nature communications 63 25964121
2012 The INO80 chromatin remodeling complex prevents polyploidy and maintains normal chromatin structure at centromeres. Genes & development 56 23207916
2020 DNA Damage-Induced Nucleosome Depletion Enhances Homology Search Independently of Local Break Movement. Molecular cell 49 32970994
2014 INO80-C and SWR-C: guardians of the genome. Journal of molecular biology 47 25451604
2021 Damage-induced chromatome dynamics link Ubiquitin ligase and proteasome recruitment to histone loss and efficient DNA repair. Molecular cell 44 33529595
2016 The INO80 Complex Requires the Arp5-Ies6 Subcomplex for Chromatin Remodeling and Metabolic Regulation. Molecular and cellular biology 44 26755556
2010 The Ino80 chromatin-remodeling complex restores chromatin structure during UV DNA damage repair. The Journal of cell biology 43 21135142
2019 Epigenetic silencing of a multifunctional plant stress regulator. eLife 42 31418686
2013 Multiple modes of regulation of the human Ino80 SNF2 ATPase by subunits of the INO80 chromatin-remodeling complex. Proceedings of the National Academy of Sciences of the United States of America 42 24297934
2009 Fission yeast Iec1-ino80-mediated nucleosome eviction regulates nucleotide and phosphate metabolism. Molecular and cellular biology 40 19933844
2015 The Ino80 complex prevents invasion of euchromatin into silent chromatin. Genes & development 36 25691465
2016 Synergy and antagonism in regulation of recombinant human INO80 chromatin remodeling complex. Nucleic acids research 34 27257055
2019 Roles of the INO80 and SWR1 Chromatin Remodeling Complexes in Plants. International journal of molecular sciences 33 31533258
2018 The INO80 chromatin remodeler sustains metabolic stability by promoting TOR signaling and regulating histone acetylation. PLoS genetics 31 29462149
2015 Assembly of the Arp5 (Actin-related Protein) Subunit Involved in Distinct INO80 Chromatin Remodeling Activities. The Journal of biological chemistry 29 26306040
2015 A Pooling Genome-Wide Association Study Combining a Pathway Analysis for Typical Sporadic Parkinson's Disease in the Han Population of Chinese Mainland. Molecular neurobiology 26 26227905
2018 Identification of Two Distinct Classes of the Human INO80 Complex Genome-Wide. G3 (Bethesda, Md.) 21 29432129
2020 Genome-Wide Meta-Analyses of FTND and TTFC Phenotypes. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 16 31294817
2020 NC2 complex is a key factor for the activation of catalase-3 transcription by regulating H2A.Z deposition. Nucleic acids research 15 32633757
2020 INO80C Remodeler Maintains Genomic Stability by Preventing Promiscuous Transcription at Replication Origins. Cell reports 15 32905765
2022 Integrated Chromatin Accessibility and Transcriptome Landscapes of 5-Fluorouracil-Resistant Colon Cancer Cells. Frontiers in cell and developmental biology 14 35252200
2022 ACTR5 controls CDKN2A and tumor progression in an INO80-independent manner. Science advances 14 36563143
2016 Response to Comment on "A histone acetylation switch regulates H2A.Z deposition by the SWR-C remodeling enzyme". Science (New York, N.Y.) 10 27463666
2022 Distinct functions of three chromatin remodelers in activator binding and preinitiation complex assembly. PLoS genetics 8 35793348
2023 Dynamic coalescence of yeast Heat Shock Protein genes bypasses the requirement for actin. Genetics 7 36659814
2023 DNA-translocation-independent role of INO80 remodeler in DNA damage repairs. The Journal of biological chemistry 6 37696438
2021 RNAi and Ino80 complex control rate limiting translocation step that moves rDNA to eroding telomeres. Nucleic acids research 5 34244792
2024 Loss of cytoplasmic actin filaments raises nuclear actin levels to drive INO80C-dependent chromosome fragmentation. Nature communications 4 39548059
2024 TORC2 inhibition triggers yeast chromosome fragmentation through misregulated Base Excision Repair of clustered oxidation events. Nature communications 3 39548071
2021 Distinct roles of nucleosome sliding and histone modifications in controlling the fidelity of transcription initiation. RNA biology 3 33280509
2025 Bromodomain proteins IBD1 and IBD2 link histone acetylation to SWR1- and INO80-mediated H2A.Z regulation in Tetrahymena. Epigenetics & chromatin 2 40764940
2022 Identification of novel PIEZO1::CBFA2T3 and INO80C::SETBP1 fusion genes in an acute myeloid leukemia patient by RNA-seq. Molecular biology reports 2 36472727
2026 esBAF and INO80C fine-tune subcompartments and differentially regulate enhancer-promoter interactions. Genetics 0 41642679
2026 The Ies6 subunit is essential for INO80-mediated nucleosome organization. Scientific reports 0 41720950
2025 esBAF and INO80C fine-tune subcompartments and differentially regulate enhancer-promoter interactions. bioRxiv : the preprint server for biology 0 41000727
2025 Transcription elongation regulated by H2B deubiquitination and H2A.Z eviction enables fungal virulence. The New phytologist 0 41272392

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