Affinage

HOXB6

Homeobox protein Hox-B6 · UniProt P17509

Length
224 aa
Mass
25.4 kDa
Annotated
2026-04-28
75 papers in source corpus 12 papers cited in narrative 12 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

HOXB6 is a homeodomain transcription factor that specifies cervicothoracic vertebral identity, controls rib formation, and regulates hematopoietic lineage decisions. Targeted disruption in mice causes anteriorizing vertebral transformations and rib defects through a mechanism requiring its linker region for cofactor recruitment (including Pax3) to target enhancers, while genetic cooperation with HOXB5 establishes cervicothoracic identity (PMID:7828847, PMID:26718008). HOXB6 physically interacts with CBP/p300 via its homeodomain to repress globin gene transcription, directly represses Sox9 by binding its promoter, and restrains erythroid progenitor expansion in bone marrow, while its overexpression expands hematopoietic stem cells and cooperates with MEIS1 to induce acute myeloid leukemia in a DNA-binding-dependent but PBX1-independent manner (PMID:15269212, PMID:15522959, PMID:10996827, PMID:32763157). HOXB6 is phosphorylated at Ser-214 by casein kinase II in vivo and undergoes differentiation-dependent isoform switching and nuclear/cytoplasmic relocalization in epithelial tissues (PMID:10327653, PMID:10906782).

Mechanistic history

Synthesis pass · year-by-year structured walk · 9 steps
  1. 1993 Medium

    Mapping of cis-regulatory elements controlling Hoxb6 expression revealed that distinct enhancers independently drive expression in limb/lateral plate mesoderm, ventral spinal cord, and mesonephros, establishing the modular transcriptional control underlying HOXB6's tissue-specific roles.

    Evidence Transgenic LacZ reporter dissection of 13.2 kb Hoxb6 genomic region in mouse embryos

    PMID:8104549

    Open questions at the time
    • Trans-acting factors binding these enhancers were not identified
    • No connection to downstream target genes
  2. 1995 High

    Gene disruption established that HOXB6 specifies cervicothoracic vertebral identity and cooperates genetically with adjacent HOXB5, resolving the functional contribution of a single posterior HOX gene to axial patterning and demonstrating nonallelic noncomplementation between paralogous HOX genes.

    Evidence Targeted knockout mice; trans-heterozygote genetic complementation; skeletal analysis

    PMID:7828847

    Open questions at the time
    • Downstream target genes mediating vertebral identity unknown
    • Mechanism of HOXB5–HOXB6 cooperation at the molecular level not defined
  3. 1999 High

    Identification of CK-II-mediated phosphorylation at Ser-214 in vivo provided the first post-translational regulatory mechanism for HOXB6, raising the question of how phosphorylation modulates DNA binding or cofactor interactions.

    Evidence In vitro kinase assays with purified CK-II; 2D tryptic phosphopeptide mapping from mouse embryonic spinal cord immunoprecipitates

    PMID:10327653

    Open questions at the time
    • Functional consequence of Ser-214 phosphorylation on transcriptional activity not tested
    • No phospho-dead mutant phenotype in vivo
  4. 2000 Medium

    Two studies clarified HOXB6's roles beyond skeletal patterning: knockout mice showed expanded erythroid progenitors in bone marrow, and differentiation-dependent isoform switching with nuclear/cytoplasmic relocalization was documented in skin, establishing HOXB6 as a regulator of both hematopoietic and epithelial differentiation.

    Evidence Hoxb6 knockout clonogenic progenitor assays; immunohistochemistry and GFP-fusion localization in keratinocytes

    PMID:10906782 PMID:10996827

    Open questions at the time
    • Target genes mediating erythroid progenitor control not identified
    • Mechanism controlling isoform switching unclear
    • Whether truncated cytoplasmic isoform has independent function not tested
  5. 2002 Medium

    Enforced expression experiments showed HOXB6 blocks granulocytic and monocytic maturation and is transiently induced during normal myelopoiesis, indicating that dynamic HOXB6 expression levels gate myeloid differentiation progression.

    Evidence Retroviral overexpression in NB4 and HL60 cells; morphological and molecular differentiation readouts

    PMID:12094253

    Open questions at the time
    • Direct transcriptional targets in myeloid cells not identified
    • Loss-of-function in myeloid lineage not performed
  6. 2004 High

    Structure-function studies resolved that HOXB6's oncogenic and transcriptional activities require DNA binding but not PBX1 interaction, and that HOXB6 physically engages CBP/p300 through its homeodomain to repress globin genes, while cooperation with MEIS1 accelerates leukemogenesis.

    Evidence Retroviral BM transduction with domain mutants and in vivo transplantation; co-IP of endogenous CBP with HOXB6 in K562 and fetal liver cells; globin RT-PCR

    PMID:15269212 PMID:15522959

    Open questions at the time
    • Genome-wide direct targets in hematopoietic cells not mapped
    • How CBP interaction leads to repression rather than activation not mechanistically resolved
    • Whether MEIS1 and HOXB6 form a physical complex not tested
  7. 2015 High

    The linker region between the homeodomain and hexapeptide was shown to be essential for rib-promoting activity by recruiting additional regulatory cofactors to target enhancers (co-occupied with Pax3), separating HOXB6's rib-patterning function from its role in somitogenesis via Lfng regulation.

    Evidence Transgenic mice expressing LR-deletion mutant; ChIP showing Hoxb6-Pax3 co-occupancy; Lfng and skeletal phenotype analysis

    PMID:26718008

    Open questions at the time
    • Identity of LR-recruited cofactors unknown
    • Whether Pax3 interaction is direct or enhancer-mediated not resolved
  8. 2016 Medium

    Quantitative phenotyping across genetic backgrounds showed HOXB6 skeletal functions are modulated by genetic modifiers, establishing Hox-controlled skeletal pattern as a quantitative trait.

    Evidence Hoxb6 knockout mice on multiple inbred backgrounds; quantitative skeletal scoring

    PMID:26800342

    Open questions at the time
    • Modifier loci not mapped
    • Molecular basis of background sensitivity unknown
  9. 2020 Medium

    HOXB6 was identified as a direct transcriptional repressor of Sox9 in the liver, with miR-126-mediated translational suppression of HOXB6 enabling SOX9+ progenitor activation during liver injury, linking HOXB6 to adult tissue regeneration.

    Evidence ChIP showing HOXB6 binding at Sox9 promoter; luciferase reporters; miR-126 target validation; CCl4 liver injury model

    PMID:32763157

    Open questions at the time
    • Whether HOXB6 represses Sox9 in other tissues not tested
    • Additional HOXB6 target genes in liver not identified

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the genome-wide direct target repertoire of HOXB6 in hematopoietic and skeletal contexts, the identity of linker-region-recruited cofactors essential for rib formation, the functional consequence of CK-II phosphorylation, and how HOXB6–CBP interaction mediates transcriptional repression rather than activation.
  • No genome-wide ChIP-seq or CUT&RUN target map in any tissue
  • No structural model of HOXB6–CBP or HOXB6–cofactor complexes
  • Functional role of Ser-214 phosphorylation untested by mutagenesis in vivo

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003677 DNA binding 4 GO:0140110 transcription regulator activity 4
Localization
GO:0005634 nucleus 3 GO:0005829 cytosol 1
Pathway
R-HSA-1266738 Developmental Biology 3
Partners
CBPHOXB5MEIS1PAX3

Evidence

Reading pass · 12 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1995 Hoxb-5 and Hoxb-6 function together to specify cervicothoracic vertebral identity; targeted disruption of hoxb-6 causes missing first rib, bifid second rib, and anteriorizing homeotic transformations of vertebrae C6–T1. Trans-heterozygotes (hoxb-5-/hoxb-6+) show the same cervicothoracic phenotype, demonstrating nonallelic noncomplementation and cooperative genetic interaction between the two adjacent genes. Gene targeting in ES cells / knockout mice; genetic complementation test (trans-heterozygotes); skeletal analysis Genes & development High 7828847
2004 HOXB6 overexpression in murine bone marrow expands hematopoietic stem cells and myeloid precursors while inhibiting erythropoiesis and lymphopoiesis, immortalizes a myelomonocytic precursor in vitro, and causes acute myeloid leukemia in vivo. These effects are largely dependent on DNA binding but independent of direct interaction with PBX1 co-factor. Co-expression of MEIS1 dramatically accelerates AML onset. Retrovirus-mediated gene transfer into murine bone marrow; structure-function analysis with DNA-binding and PBX1-interaction mutants; in vivo transplantation; clonogenic assays Blood High 15522959
2004 HOXB6 represses alpha- and gamma-globin mRNA levels in a DNA-binding-dependent manner. HOXB6 protein co-precipitates endogenous CBP (CREB-binding protein) from nuclear and cytoplasmic compartments of transfected K562 cells and from murine fetal liver cells. The CBP interaction is localized to the homeodomain but does not require helix 3. PBX co-factor interaction is not required for HOXB6 biological activity in this model. Stable transfection of K562 cells; RT-PCR for globin transcripts; co-immunoprecipitation of endogenous CBP with exogenous and endogenous HOXB6; homeodomain deletion/mutation analysis The Journal of biological chemistry High 15269212
2000 HOXB6 protein undergoes a change in subcellular localization during epidermal development: it is cytoplasmic in fetal epidermis but substantially nuclear in adult skin. A truncated HOXB6 isoform lacking the homeodomain is expressed in undifferentiated keratinocytes and is largely cytoplasmic, while full-length HOXB6 localizes to the nucleus. Nuclear HOXB6 in adult skin does not co-localize with PBX proteins, suggesting PBX-independent nuclear function. Immunohistochemistry; Western blot; GFP-fusion protein localization in live cells; RNA analysis of isoforms Developmental dynamics Medium 10906782
1999 HOXB6 (Hoxb-6) is phosphorylated in vivo at serine-214 by casein kinase II (CK-II). This phosphorylation site is conserved across species. Hoxb-6 is also phosphorylated in vitro by cAMP-dependent protein kinase. The same CK-II phosphopeptide detected in vitro is phosphorylated in embryonic mouse spinal cord in vivo. Baculovirus expression in Sf9 cells; in vitro kinase assays with purified CK-II and PKA; two-dimensional tryptic phosphopeptide mapping; immunoprecipitation from mouse embryonic spinal cords The Journal of experimental zoology High 10327653
2015 The linker region (LR) connecting the Hoxb6 homeodomain and the hexapeptide is essential for rib-promoting activity in mice. LR-defective Hoxb6 can still bind a target enhancer together with Pax3 but acts as a dominant negative, indicating the LR recruits additional regulatory factors to target DNA. Hoxb6 also regulates somitogenesis by dysregulating Lfng expression in a manner independent of its rib-promoting activity. Transgenic mice expressing LR-deletion mutant HOXB6; ChIP/enhancer binding assays showing Hoxb6-Pax3 co-occupancy; analysis of Lfng expression; skeletal phenotype analysis Development High 26718008
2000 Targeted disruption of Hoxb-6 in mice results in an increased number of early erythroid progenitor cells (BFU-E) in bone marrow and fetal liver, while differentiation of other hematopoietic lineages is unaffected. This establishes a role for Hoxb-6 in controlling the generation, proliferation, or survival of erythroid progenitors. Gene targeting in mice; clonogenic progenitor cell assays (colony-forming unit assays for multiple lineages) American journal of hematology Medium 10996827
2002 Enforced expression of HOXB6 in promyelocytic NB4 cells or myeloblastic HL60 cells inhibits granulocytic or monocytic maturation respectively. HOXB6 expression is transiently induced during normal granulocytopoiesis and monocytopoiesis with an initial induction followed by blockade at early maturation, indicating that regulated HOXB6 expression is required for normal myeloid differentiation. Retroviral overexpression in NB4 and HL60 cell lines; differentiation assays with morphological and molecular readouts Leukemia Medium 12094253
1993 Three distinct cis-regulatory elements govern Hoxb-6 expression: a limb/lateral plate mesoderm (LPM) enhancer directing expression to limb buds and ventro-lateral mesenchyme, an element for ventral spinal cord expression, and an element for mesonephric structures. The limb/LPM element functions as an orientation- and promoter-independent enhancer. Transgenic mouse embryos carrying LacZ reporter gene fused to different Hoxb-6 genomic fragments; 13.2 kb genomic region systematically analyzed Developmental dynamics Medium 8104549
2020 HOXB6 is a direct transcriptional repressor of Sox9: HOXB6 protein binds to the Sox9 promoter and inhibits Sox9 expression. In liver injury, miR-126 suppresses HOXB6 translation, relieving Sox9 repression and enabling SOX9+ liver progenitor cell proliferation and differentiation. Luciferase reporter assay with Sox9 promoter; chromatin immunoprecipitation (ChIP) showing HOXB6 binding to Sox9 promoter; miR-126 target validation; CCl4 liver injury model Stem cell reports Medium 32763157
2016 Hoxb6 controls multiple independent aspects of skeletal patterning at the cervico-thoracic junction, and its function is subject to modulation by genetic background, establishing Hox-controlled skeletal pattern as a quantitative trait with gene-gene interactions. Hoxb6 knockout mice on multiple genetic backgrounds; quantitative skeletal phenotyping PloS one Medium 26800342
2024 Loss of HOXB6 in pancreatic cancer cells inhibits cell proliferation, induces apoptosis and senescence, enhances gemcitabine sensitivity, and affects transcription of immune response pathways, resulting in increased sensitivity to macrophage anti-tumorigenic activity. siRNA/shRNA knockdown in PDAC cell lines; proliferation, apoptosis, and senescence assays; transcriptomic analysis; co-culture with macrophages; drug sensitivity assays bioRxivpreprint Low bio_10.1101_2024.09.06.611619

Source papers

Stage 0 corpus · 75 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1989 Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain. Nature 515 2571936
1990 Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells. Nature 474 1975088
1992 Exogenous retinoic acid rapidly induces anterior ectopic expression of murine Hox-2 genes in vivo. Development (Cambridge, England) 442 1363087
1993 The zinc finger gene Krox20 regulates HoxB2 (Hox2.8) during hindbrain segmentation. Cell 291 8093858
1990 Isolation of the mouse Hox-2.9 gene; analysis of embryonic expression suggests that positional information along the anterior-posterior axis is specified by mesoderm. Development (Cambridge, England) 287 1983472
1991 Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells. Nature 282 1672446
1995 Genetic interaction between hoxb-5 and hoxb-6 is revealed by nonallelic noncomplementation. Genes & development 233 7828847
1992 Cell adhesion molecules as targets for Hox genes: neural cell adhesion molecule promoter activity is modulated by cotransfection with Hox-2.5 and -2.4. Proceedings of the National Academy of Sciences of the United States of America 221 1347944
1991 Effects of retinoic acid excess on expression of Hox-2.9 and Krox-20 and on morphological segmentation in the hindbrain of mouse embryos. The EMBO journal 219 1915273
1990 Mouse Hox-2.2 specifies thoracic segmental identity in Drosophila embryos and larvae. Cell 163 1979525
1992 Neuroectodermal autonomy of Hox-2.9 expression revealed by rhombomere transpositions. Nature 151 1545869
1988 Characterization of a murine homeo box gene, Hox-2.6, related to the Drosophila Deformed gene. Genes & development 143 2463210
1989 Expression of Hox-2.4 homeobox gene directed by proviral insertion in a myeloid leukemia. Nucleic acids research 130 2564662
1992 Analysis of the murine Hox-2.7 gene: conserved alternative transcripts with differential distributions in the nervous system and the potential for shared regulatory regions. The EMBO journal 118 1582411
1990 Hox-2.3 upstream sequences mediate lacZ expression in intermediate mesoderm derivatives of transgenic mice. Development (Cambridge, England) 105 1977573
1991 The murine Hox-2 genes display dynamic dorsoventral patterns of expression during central nervous system development. Development (Cambridge, England) 100 1685115
2004 HOXB6 overexpression in murine bone marrow immortalizes a myelomonocytic precursor in vitro and causes hematopoietic stem cell expansion and acute myeloid leukemia in vivo. Blood 99 15522959
1991 The expression of murine Hox-2 genes is dependent on the differentiation pathway and displays a collinear sensitivity to retinoic acid in F9 cells and Xenopus embryos. Nucleic acids research 99 1682879
1993 Conditional immortalization of mouse myelomonocytic, megakaryocytic and mast cell progenitors by the Hox-2.4 homeobox gene. The EMBO journal 97 8104786
1987 Sequence analysis of the murine Hox-2.2, -2.3, and -2.4 homeo boxes: evolutionary and structural comparisons. Genomics 72 2891608
1991 The oncogenic potential of an activated Hox-2.4 homeobox gene in mouse fibroblasts. Molecular and cellular biology 68 1670897
1989 Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system. Differentiation; research in biological diversity 64 2570724
1989 The developmental expression pattern of a new murine homeo box gene: Hox-2.5. Developmental biology 61 2567250
1990 Expression of the murine homeobox-containing gene Hox-2.3 suggests multiple time-dependent and tissue-specific roles during development. Development (Cambridge, England) 60 1983116
1992 Ectopic expression of Hox-2.3 induces craniofacial and skeletal malformations in transgenic mice. Mechanisms of development 54 1362649
2020 An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene. Neurobiology of aging 53 32745807
1993 Colinearity in the Xenopus laevis Hox-2 complex. Mechanisms of development 53 8095151
1993 Cooperative DNA binding of the human HoxB5 (Hox-2.1) protein is under redox regulation in vitro. Molecular and cellular biology 51 8101633
1988 Structure and expression of Hox-2.2, a murine homeobox-containing gene. Proceedings of the National Academy of Sciences of the United States of America 51 2899893
1993 Proximal cis-acting elements cooperate to set Hoxb-7 (Hox-2.3) expression boundaries in transgenic mice. Development (Cambridge, England) 50 8104144
2000 Deregulated expression of homeobox-containing genes, HOXB6, B8, C8, C9, and Cdx-1, in human colon cancer cell lines. Biochemical and biophysical research communications 48 10833444
2000 Disruption of the homeobox gene Hoxb-6 in mice results in increased numbers of early erythrocyte progenitors. American journal of hematology 48 10996827
1990 The zebrafish homeobox gene hox-2.2: transcription unit, potential regulatory regions and in situ localization of transcripts. The EMBO journal 47 1968004
2006 Mutation screening of BMP4, BMP7, HOXA4 and HOXB6 genes in Chinese patients with hypospadias. European journal of human genetics : EJHG 46 17003840
1999 Evolution of a HOXB6 intergenic region within the great apes and humans. Journal of human evolution 46 10330333
1990 A yeast artificial chromosome containing the mouse homeobox cluster Hox-2. Proceedings of the National Academy of Sciences of the United States of America 45 1972280
1992 Xenopus Hox-2 genes are expressed sequentially after the onset of gastrulation and are differentially inducible by retinoic acid. Development (Cambridge, England) 43 1363722
1992 Dominant mutation of the murine Hox-2.2 gene results in developmental abnormalities. The Journal of experimental zoology 41 1358998
1992 Inhibition of specific pathways of myeloid cell differentiation by an activated Hox-2.4 homeobox gene. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 41 1359901
2000 Changes in HOXB6 homeodomain protein structure and localization during human epidermal development and differentiation. Developmental dynamics : an official publication of the American Association of Anatomists 38 10906782
1997 Lineage-specific regulation of hematopoiesis by HOX-B8 (HOX-2.4): inhibition of granulocytic differentiation and potentiation of monocytic differentiation. Blood 38 9292516
2020 ST8SIA6-AS1 promotes hepatocellular carcinoma by absorbing miR-5195-3p to regulate HOXB6. Cancer biology & therapy 35 32420798
1992 Expression of selected human HOX-2 genes in B/T acute lymphoid leukemia and interleukin-2/interleukin-1 beta-stimulated natural killer lymphocytes. Blood 35 1351762
1993 Analysis of LacZ reporter genes in transgenic embryos suggests the presence of several cis-acting regulatory elements in the murine Hoxb-6 gene. Developmental dynamics : an official publication of the American Association of Anatomists 33 8104549
1991 Expression of the HOX-2.3 homeobox gene in human lymphocytes and lymphoid tissues. Blood 33 1676919
1986 The murine Hox-2 cluster of homeo box containing genes maps distal on chromosome 11 near the tail-short (Ts) locus. Cytogenetics and cell genetics 32 2875852
1992 DNA sequence polymorphism within hominoid species exceeds the number of phylogenetically informative characters for a HOX2 locus. Molecular biology and evolution 30 1352841
2004 HOXB6 protein is bound to CREB-binding protein and represses globin expression in a DNA binding-dependent, PBX interaction-independent process. The Journal of biological chemistry 28 15269212
2002 Expression pattern of HOXB6 homeobox gene in myelomonocytic differentiation and acute myeloid leukemia. Leukemia 28 12094253
1988 A zebrafish homologue of the murine Hox-2.1 gene. FEBS letters 25 2895022
1987 The mouse Hox2.3 homeobox-containing gene: regulation in differentiating pluripotent stem cells and expression pattern in embryos. Differentiation; research in biological diversity 25 2892751
1988 In situ hybridization patterns of zebrafish homeobox genes homologous to Hox-2.1 and En-2 of mouse. Biochemical and biophysical research communications 24 2904810
2015 Hoxb6 can interfere with somitogenesis in the posterior embryo through a mechanism independent of its rib-promoting activity. Development (Cambridge, England) 23 26718008
1991 Characterization of the murine Hox-2.3 promoter: involvement of the transcription factor USF (MLTF). Mechanisms of development 22 1677811
1988 The Hox-2 homeo box gene complex on mouse chromosome 11 is closely linked to Re. Genetics 18 2896141
2008 Unique spatial and cellular expression patterns of Hoxa5, Hoxb4, and Hoxb6 proteins in normal developing murine lung are modified in pulmonary hypoplasia. Birth defects research. Part A, Clinical and molecular teratology 17 18553509
1991 A deletion and a rearrangement distinguish between the intracisternal A-particle of Hox-2.4 and that of interleukin-3 in the same leukemic cells. Virology 17 1673811
1991 Possible role of DNA topoisomerase II on transcription of the homeobox gene Hox-2.1 in F9 embryonal carcinoma cells. Nucleic acids research 17 1683482
2020 MiR-126 Regulates Properties of SOX9+ Liver Progenitor Cells during Liver Repair by Targeting Hoxb6. Stem cell reports 13 32763157
1993 Induction of HOX-2 genes in P19 embryocarcinoma cells is dependent on retinoic acid receptor alpha. Experimental cell research 13 8097725
1999 Phylogenetically conserved CK-II phosphorylation site of the murine homeodomain protein Hoxb-6. The Journal of experimental zoology 12 10327653
1992 The murine Hox-2.4 promoter contains a functional octamer motif. Nucleic acids research 11 1349742
2023 Hsa_circ_0007031 promotes the proliferation and migration of osteosarcoma cells by sponging miR-196a-5p to regulate the HOXB6. Biochemical pharmacology 10 37356630
2005 Ets identified as a trans-regulatory factor of amphioxus Hox2 by transgenic analysis using ascidian embryos. Developmental biology 10 16051213
1988 Restriction fragment length polymorphism and chromosome mapping of a mouse homeo box gene, Hox-2.1. Biochemical genetics 10 2907403
2016 Developmental Patterning as a Quantitative Trait: Genetic Modulation of the Hoxb6 Mutant Skeletal Phenotype. PloS one 8 26800342
1996 The limb/LPM enhancer of the murine Hoxb6 gene: reporter gene analysis in transgenic embryos and studies of DNA-protein interactions. Pharmaceutica acta Helvetiae 7 8786996
1994 The 5'-sequence of the murine Hox-b3 (Hox-2.7) gene and its intron contain multiple transcription-regulatory elements. The International journal of biochemistry 6 7890121
1992 Assignment of the HOX2 and HOX3 gene clusters to the bovine chromosome regions 19q17-qter and 5q14-23. Animal genetics 5 1359814
1987 A TaqI restriction fragment length polymorphism at the Hox-2.1 locus cosegregates with the Dlb-1 locus on mouse chromosome 11. Nucleic acids research 3 2882472
1991 Production of mouse Hox-2.1 protein in Escherichia coli: characterisation of in vitro binding to DNA. Gene 2 1937017
1992 DNA-binding activity of the murine homeodomain protein Hox-2.3 produced by a hybrid phage T7/vaccinia virus system. Gene 1 1353046
2001 [Influence of human cytomegalovirus infection on the expression of HOXB5, HOXB6, HOXB7, and HOXB8 genes in gliomaous cells]. Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University 0 12536483
2001 [Influence of human cytomegalovirus infection on the expressions of HOXB1, HOXB5, HOXB6, and HOXB9 genes in human embryo lung cells]. Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University 0 12536675
1995 The Hox-2.4 gene is not involved in the generation of IL-3 dependent multipotent FDCP-mix cell lines. Growth factors (Chur, Switzerland) 0 8619923