Affinage

GATA6

Transcription factor GATA-6 · UniProt Q92908

Length
595 aa
Mass
60.0 kDa
Annotated
2026-04-28
100 papers in source corpus 57 papers cited in narrative 56 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

GATA6 is a zinc-finger transcription factor that functions as a pioneer factor and dosage-sensitive master regulator of endoderm, cardiac, pancreatic, pulmonary, adrenal, adipose, and epithelial lineage specification. It binds (A/T/C)GATA(A/T) consensus motifs to directly activate targets including HNF4, SP-A, LGR5, BMPR2, TBX3, Wnt6, and CPI-17, or repress targets such as VEGF-C and the Shh enhancer MACS1, cooperating with partners GATA4, TBX5, FOXA2, EOMES/SMAD2/3, SP1, and p300 at co-occupied enhancers and promoters (PMID:9832509, PMID:9784406, PMID:30629940, PMID:35871075, PMID:26932670). Its activity is regulated post-translationally by Erk1/2 phosphorylation at S264, which drives a positive-feedback loop committing cells to primitive endoderm, and by TWIST1-mediated protein degradation in smooth muscle cells, while its locus is epigenetically controlled by EZH2-dependent histone methylation, TET2-dependent hydroxymethylation, and EP300-mediated acetylation (PMID:29454706, PMID:32692930, PMID:32907838, PMID:33915173, PMID:35536676). Beyond development, GATA6 maintains tissue homeostasis by regulating nuclear envelope integrity and cytokinesis, epithelial barrier function through tight junction proteins, peritoneal macrophage metabolism via aspartoacylase, vascular smooth muscle contractility, β-cell insulin biosynthesis, and DNA damage repair pathways, while acting as a context-dependent oncogene or tumor suppressor across multiple cancer types (PMID:19581290, PMID:34374415, PMID:25024137, PMID:29263149, PMID:25596178, PMID:18535672).

Mechanistic history

Synthesis pass · year-by-year structured walk · 15 steps
  1. 1998 High

    Establishing GATA6 as a sequence-specific DNA-binding transcription factor essential for visceral endoderm differentiation resolved the question of what upstream regulator controlled HNF4 and primitive endoderm formation.

    Evidence SELEX/EMSA defined the GATA6 binding consensus; GATA6-null mice lacked HNF4 expression and visceral endoderm

    PMID:9784406 PMID:9832509

    Open questions at the time
    • Crystal structure of GATA6 zinc-finger–DNA complex not determined
    • Identity of cofactors mediating GATA6 transactivation at HNF4 unknown
  2. 2003 High

    Demonstrating that GATA6 maintains (rather than initiates) the cardiac gene program and that precise GATA6 dosage is required for lung morphogenesis established its role as a tissue-maintenance factor beyond initial lineage specification.

    Evidence Morpholino knockdown in Xenopus/zebrafish showed reduced contractile and BMP4 genes; transgenic SP-C–GATA6 mice showed inhibited alveolar septation

    PMID:12909592 PMID:12912923

    Open questions at the time
    • Direct cardiac target genes not mapped genome-wide at this stage
    • Mechanism by which GATA6 dosage is sensed in lung epithelium unclear
  3. 2006 High

    Genetic interaction studies between GATA4 and GATA6 revealed dose-dependent redundancy in cardiovascular and pancreatic development, explaining why single heterozygous loss is often tolerated while compound loss is lethal.

    Evidence Compound GATA4/GATA6 heterozygotes died with cardiac defects; pancreas-specific double KO caused agenesis; zebrafish gata5/gata6 double KD was heartless

    PMID:16847256 PMID:17950269 PMID:23006325

    Open questions at the time
    • Whether GATA4 and GATA6 bind identical or distinct genomic sites was not resolved
    • Quantitative relationship between GATA factor protein levels and phenotype threshold unknown
  4. 2008 High

    Identification of physical and genetic interaction between GATA6 and TBX5, and demonstration that GATA6 is amplified as a lineage-specific oncogene in pancreatic cancer, expanded its mechanistic roles from developmental factor to disease driver.

    Evidence GATA6/TBX5 synergized on ANF promoter and compound heterozygotes showed cardiac defects; GATA6 amplification in PDAC with siRNA-dependent proliferation arrest

    PMID:18535672 PMID:19084512

    Open questions at the time
    • Structural basis of GATA6–TBX5 interaction undetermined
    • Oncogenic versus tumor-suppressive context-dependency not yet resolved
  5. 2012 High

    Direct promoter-binding studies on diverse targets (Wnt6, CPI-17, calreticulin) and the finding that GATA6 cooperates with FOXA2 and NF-κB at specific promoters established a model of combinatorial, context-dependent transcriptional regulation.

    Evidence ChIP and EMSA showed direct GATA6 binding to Wnt6, CPI-17, and calreticulin promoters; FOXA2 and NF-κB co-binding demonstrated by co-transfection and reporter assays

    PMID:18303859 PMID:22607194 PMID:23275439

    Open questions at the time
    • Global repertoire of GATA6-cooperating factors not systematically catalogued
    • Whether GATA6 recruitment to these targets is cell-type-restricted not tested
  6. 2014 High

    Quantitative analysis of ICM lineage commitment showed GATA6 protein levels control the timing and speed of primitive endoderm specification downstream of FGF/ERK signaling, placing GATA6 as the nodal integrator of ICM fate decisions.

    Evidence Conditional and null allele mouse genetics with single-cell-resolution imaging; FGF pathway epistasis

    PMID:24835466

    Open questions at the time
    • Post-translational mechanism translating FGF/ERK signaling to GATA6 protein stabilization/activity not yet identified
  7. 2015 High

    Genome-wide ChIP-seq in reprogramming and pancreatic contexts demonstrated that GATA6 acts as a pioneer factor, directly binding and remodeling chromatin at both pluripotency and differentiation loci, resolving whether GATA6 requires pre-existing open chromatin.

    Evidence GATA6 alone reprogrammed ES and neural cells to iXEN; ChIP-seq showed enrichment near pluripotency and endoderm genes; pancreatic Gata6 KO with KrasG12V accelerated tumors

    PMID:25596178 PMID:26109048

    Open questions at the time
    • Pioneer factor activity not formally demonstrated by nucleosome-binding assays
    • Whether GATA6 pioneer activity requires specific cofactors unclear
  8. 2016 High

    Discovery that GATA4/GATA6 directly repress the Shh enhancer MACS1 to maintain pancreatic identity, and that GATA6 specifies sebaceous duct lineage with wound-induced dedifferentiation capacity, broadened GATA6 function to active transcriptional repression and adult stem cell plasticity.

    Evidence Conditional double KO with GATA-binding site mutagenesis in Shh enhancer; Gata6 conditional KO in epidermis with lineage tracing and wound healing

    PMID:26932670 PMID:28504705

    Open questions at the time
    • Co-repressor complexes mediating GATA6-dependent Shh silencing not identified
    • Signals triggering GATA6+ cell dedifferentiation during wound healing unknown
  9. 2018 High

    Identification of Erk1/2-dependent S264 phosphorylation as the switch activating GATA6's positive autoregulatory loop resolved how FGF/ERK signaling is mechanistically transduced into primitive endoderm commitment.

    Evidence S264A phospho-dead mutant failed to activate Gata6 promoter; Gata6-H2BGFP knock-in reporter confirmed in vivo

    PMID:29454706

    Open questions at the time
    • Whether additional phosphorylation sites modulate GATA6 activity in other lineages untested
    • Phosphatase(s) reversing S264 phosphorylation unknown
  10. 2018 High

    Demonstration that TWIST1 promotes GATA6 protein degradation to reduce BMPR2 expression in pulmonary hypertension, and that Gata6 haploinsufficiency causes bicuspid aortic valve via MMP9 dysregulation, established post-translational regulation and cardiovascular disease mechanisms.

    Evidence Mass spectrometry/Co-IP identified TWIST1–GATA6 interaction; ChIP confirmed GATA6 at BMPR2 promoter; cell-specific Cre deletions mapped BAV to Isl1+ SHF myocytes

    PMID:29567669 PMID:32692930

    Open questions at the time
    • Ubiquitin ligase mediating TWIST1-induced GATA6 degradation not identified
    • Whether GATA6 directly binds MMP9 regulatory elements untested
  11. 2019 High

    Genome-wide co-occupancy of GATA6 with EOMES/SMAD2/3 at endoderm enhancers in human PSCs, and direct cross-repression of Gata6 by Gata4, defined the cooperative and antagonistic transcription factor networks governing endoderm and cardiac development.

    Evidence ChIP-seq in GATA6-KO/het hPSCs showed co-binding at endoderm enhancers; ChIP-qPCR and reporter assay showed Gata4 directly represses Gata6 promoter

    PMID:30629940 PMID:31120883

    Open questions at the time
    • Whether GATA6–EOMES co-binding is simultaneous or sequential not determined
    • Species differences between human and mouse GATA6 dependency in pancreatic ontogeny not fully explained
  12. 2020 High

    Epigenetic regulation of GATA6 itself was established as a key axis in pancreatic cancer subtype identity: EZH2-mediated histone methylation silences GATA6 to promote basal/squamous phenotype, and GATA6 functions as a pioneer factor whose variant alleles can create ectopic chromatin accessibility.

    Evidence EZH2 inhibition restored GATA6 and classical signature; GATA6 rescue reversed invasiveness; ATAC-seq in patient-derived iPSCs with GATA6 variants showed altered chromatin accessibility

    PMID:32907838 PMID:33054971

    Open questions at the time
    • Whether EZH2 directly methylates the GATA6 locus or acts indirectly not resolved
    • Structural basis of variant-specific pioneer activity changes unknown
  13. 2021 High

    The SMAD4–TET2–5hmC–GATA6 axis was identified as the epigenetic pathway maintaining classical PDAC identity, demonstrating that GATA6 expression is controlled by active DNA demethylation and providing a pharmacological target (metformin/ascorbic acid) for subtype reversion.

    Evidence Genome-wide oxidative bisulfite sequencing; TET2 stabilization restored 5hmC at GATA6 and reverted squamous phenotype in vivo

    PMID:33915173

    Open questions at the time
    • Whether TET2-mediated 5hmC at GATA6 is sufficient or requires additional chromatin remodelers unknown
    • Long-term efficacy of pharmacological GATA6 restoration in PDAC not established
  14. 2022 High

    Genome-wide analysis of NANOG–GATA6 co-binding and 3D chromatin reorganization upon GATA6 induction resolved how ICM plasticity is maintained by co-occupancy and how lineage commitment occurs through rapid enhancer-promoter contact remodeling, while EP300 was identified as a direct upstream regulator of GATA6 in PDAC.

    Evidence ChIP-seq, ATAC-seq, Hi-C in ES cells and blastocysts; in vivo CRISPR screen identified EP300 loss as silencing GATA6 in PDAC

    PMID:35536676 PMID:35871075

    Open questions at the time
    • Kinetics and order of TF eviction versus enhancer-promoter rewiring during PrE commitment not resolved
    • Whether EP300 acetylates GATA6 protein directly or only regulates its transcription unknown
  15. 2023 High

    Extension of GATA6 function to brown adipose tissue development, endothelial inflammatory signaling in atherosclerosis, and vascular smooth muscle senescence/DNA damage repair demonstrated that GATA6 operates in diverse post-developmental and pathological contexts beyond its canonical developmental roles.

    Evidence BAT-lineage conditional KO lost BAT; endothelial Gata6 KO in ApoEKO mice reduced atherosclerosis via direct Cmpk2/Ccl5 activation; GATA6 impeded ATM-mediated DNA repair in VSMCs

    PMID:37339559 PMID:37647897 PMID:37914087

    Open questions at the time
    • Whether GATA6's role in DNA damage repair is transcription-dependent or involves direct protein interactions with repair machinery unknown
    • Signals activating GATA6 in endothelial cells during atherogenesis not identified

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the structural basis of GATA6 pioneer activity on nucleosomal DNA, the identity of E3 ubiquitin ligases controlling GATA6 protein turnover, the full spectrum of tissue-specific cofactor dependencies, and how GATA6 switches between activator and repressor functions at different loci.
  • No crystal or cryo-EM structure of GATA6 on nucleosomal substrate
  • Ubiquitin ligase(s) for GATA6 degradation not identified
  • Genome-wide catalog of activating versus repressing GATA6 binding events across tissues not available

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 16 GO:0003677 DNA binding 6
Localization
GO:0005634 nucleus 4
Pathway
R-HSA-1266738 Developmental Biology 13 R-HSA-74160 Gene expression (Transcription) 12 R-HSA-1643685 Disease 6 R-HSA-162582 Signal Transduction 3 R-HSA-4839726 Chromatin organization 2
Partners
EOMESEP300FOXA2GATA4NANOGSP1TBX5TWIST1

Evidence

Reading pass · 56 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1998 GATA6 lies upstream of HNF4 in a transcriptional cascade required for visceral endoderm differentiation; GATA6-null mice lack HNF4 expression and fail to form visceral endoderm, while forced GATA6 expression activates the HNF4 promoter in non-endodermal cells. Gene targeting (knockout mice and ES cells), forced expression/promoter activation assay, chimeric mouse analysis Genes & development High 9832509
2001 GATA6 overexpression in cardiomyocytes (via adenovirus) is sufficient to induce hypertrophic growth, enhanced sarcomeric organization, and increased cell surface area; a dominant-negative GATA4-engrailed repressor blocks both GATA6-directed transcription and agonist-induced cardiomyocyte hypertrophy, demonstrating GATA6 is a necessary mediator of the hypertrophic program. Recombinant adenovirus overexpression in primary cardiomyocytes, dominant-negative fusion protein, transgenic mice, protein synthesis/cell area measurements The Journal of biological chemistry High 11356841
1998 Human GATA-6 zinc finger region binds the consensus sequence (A/T/C)GATA(A/T) with a preference for AGAT(A/T)A; binding order is GATA > GATT > GATC, and the zinc finger domain alone is sufficient to specify this DNA-binding selectivity. PCR-mediated random-site selection (SELEX), filter binding, gel-mobility shift assay (EMSA), GST-fusion protein, COS-1 cell expression Biochemical and biophysical research communications High 9784406
2000 GATA-6 activates transcription of surfactant protein A (SP-A) by binding a consensus GATA-binding site at positions -69 to -64 of the SP-A promoter; deletion of this site abolishes GATA-6 transactivation, and a GATA-6-engrailed repressor inhibits basal SP-A expression. GATA-6 and TTF-1 act additively on the SP-A promoter with mutual dependency on each other's binding sites. Reporter (CAT) cotransfection assay, deletion/mutation analysis of promoter, EMSA with supershift using GATA-6 antibody, dominant-negative repressor, in situ hybridization The Journal of biological chemistry High 10625644
2003 GATA-6 is required in both cardiac mesoderm and anterior endoderm for cardiomyocyte maturation in Xenopus and zebrafish; morpholino knockdown reduces expression of contractile genes, BMP-4, and Nkx2 family members at the same stage, indicating a maintenance (not initiation) role for GATA-6 in the cardiac gene program. Antisense morpholino oligonucleotide knockdown in Xenopus and zebrafish, tissue-specific perturbation, gene expression analysis The EMBO journal High 12912923
2003 Elevated GATA-6 expression in respiratory epithelial cells (under SP-C promoter) inhibits alveolar septation and terminal differentiation of distal pulmonary epithelium, demonstrating that precise temporal-spatial regulation of GATA-6 is required for normal lung morphogenesis. Transgenic mouse overexpression (SP-C promoter-driven GATA-6), histology, electron microscopy, glycogen staining, lung mechanics measurements American journal of physiology. Lung cellular and molecular physiology High 12909592
2006 GATA4 and GATA6 function at a shared dose-dependent threshold for cardiovascular development; compound GATA4/GATA6 heterozygous mice die by E13.5 with thin-walled myocardium, septal defects, and reduced MEF2C and β-myosin heavy chain expression, revealing genetic interaction and dosage sensitivity between the two factors in cardiomyocyte proliferation. Compound heterozygous mouse genetics, histology, immunofluorescence, gene expression analysis Proceedings of the National Academy of Sciences of the United States of America High 16847256
2007 Gata5 and Gata6 are functionally redundant in zebrafish for specification of cardiomyocytes; co-depletion of gata5 and gata6 produces a heartless phenotype, whereas restoring either factor rescues cardiomyocyte specification. Morpholino double knockdown in zebrafish, rescue experiments, phenotypic analysis Developmental biology High 17950269
2008 Gata6 interacts physically with Tbx5; Gata6 and Tbx5 synergistically activate the atrial natriuretic factor promoter, and compound Gata6/Tbx5 heterozygous mice exhibit incompletely penetrant neonatal lethality and thin myocardium, demonstrating genetic interaction in cardiac morphogenesis. Reporter (luciferase) synergy assay, compound heterozygous mouse genetics, gene expression analysis Developmental biology High 19084512
2008 GATA6 is amplified and overexpressed in pancreatobiliary cancers; siRNA-mediated knockdown of GATA6 in pancreatic cancer cell lines with amplification reduces cell proliferation, cell cycle progression, and colony formation, indicating GATA6 drives oncogenic phenotypes in a lineage-specific manner. Array-based genomic profiling, siRNA knockdown, cell proliferation/colony formation assays, immunostaining, gene expression profiling PLoS genetics High 18535672
2008 GATA6 expression is dynamic during primitive endoderm formation: initially co-expressed with GATA4 in all primitive endoderm cells, GATA6 becomes restricted to parietal endoderm by E5.0-5.5, distinguishing parietal from visceral endoderm lineages. GATA6 null embryos fail to form a morphologically recognizable primitive endoderm layer. Immunofluorescence, in situ hybridization, GATA6 null mouse analysis, staged embryo analysis Developmental dynamics High 18816845
2008 GATA6 and Evi-1 transcription factors both bind site 1 on the calreticulin promoter; GATA6 activates calreticulin gene transcription in cardiomyocytes while Evi-1 represses it and suppresses GATA6-mediated transactivation, demonstrating antagonistic regulation of the calreticulin gene during cardiac development. EMSA, ChIP, site-specific mutagenesis, reporter assay, cotransfection Biochemistry High 18303859
2009 Loss of GATA6 by siRNA in human ovarian surface epithelial cells causes deformation of the nuclear envelope, failure of cytokinesis, and formation of polyploid/aneuploid cells; loss of the nuclear envelope protein emerin mediates these consequences, as direct emerin siRNA knockdown phenocopies GATA6 suppression. siRNA knockdown, nuclear morphology analysis, cytokinesis assay, flow cytometry (ploidy), emerin expression analysis Molecular and cellular biology Medium 19581290
2012 Simultaneous pancreas-specific deletion of both Gata4 and Gata6 (but not either alone) causes severe pancreatic agenesis due to disruption of pancreatic progenitor cell proliferation, defects in branching morphogenesis, and failure to induce CPA1+ and NEUROG3+ progenitor differentiation, demonstrating functional redundancy with dosage sensitivity. Conditional knockout (Pdx1-Cre), histology, immunofluorescence, gene expression analysis The Journal of clinical investigation High 23006325 23006330
2014 GATA6 is necessary for primitive endoderm (PrE) specification in the mouse blastocyst; GATA6 levels regulate the timing and speed of ICM lineage commitment, and GATA6 is required for PrE specification downstream of FGF/ERK signaling, acting as a nodal point in the ICM gene regulatory network interacting with NANOG. Conditional and null allele mouse genetics, quantitative single-cell-resolution image analysis, FGF signaling perturbation Developmental cell High 24835466
2014 Gata6 regulates the survival and metabolism of resident peritoneal macrophages; Gata6-deficient peritoneal macrophages show increased death rates, skewed metabolism toward oxidative phosphorylation, and spontaneous induction of alternative activation markers. Gata6 directly regulates aspartoacylase (Aspa), which facilitates acetyl-CoA generation, and Aspa-null mice phenocopy Gata6-deficient macrophages. Lyz2-Cre x Gata6(flox/flox) conditional KO, flow cytometry, gene expression profiling, metabolic assays, Aspa mutant mice The Journal of experimental medicine High 25024137
2014 GATA6 directly activates LGR5 expression in colorectal cancer cells; GATA6 is upregulated due to downregulation of miR-363 (which directly targets GATA6 3'UTR), and the miR-363–GATA6–LGR5 pathway is required for colorectal cancer tumorigenicity. Luciferase reporter assay, ChIP, siRNA/overexpression, xenograft tumorigenicity assay Nature communications High 24452072
2015 Gata6 alone is sufficient to reprogram multiple cell types (pluripotent ES cells, differentiated neural cells, and human ESCs) to induced extraembryonic endoderm stem cells; ChIP-seq shows Gata6 enrichment near pluripotency and endoderm genes, functioning as both a direct repressor (of Nanog, Esrrb, Sox2, Oct4 in step-wise fashion) and activator of ExEn genes. Transcription factor-mediated reprogramming, ChIP-seq, transcriptional profiling (RNA-seq), human ESC differentiation Genes & development High 26109048
2015 Gata6 maintains the acinar differentiation program in the mouse pancreas; Gata6 ablation renders acinar cells more sensitive to KrasG12V, accelerating tumor development. ChIP-seq and RNA-seq show Gata6 exerts tumor-suppressive effects via promotion of differentiation, suppression of inflammatory pathways, and direct repression of EGFR pathway genes. Genetically engineered mouse models, ChIP-seq, RNA-seq, GATA6 silencing in human PDAC cells, histopathology Gut High 25596178
2015 REG4 is a direct transcriptional target of GATA6 in colorectal cancer; GATA6-mediated REG4 activation enhances adherent cell growth and tumorigenicity, while LGR5 activation (also GATA6-dependent) supports clonogenicity, and both are suppressed by miR-363 targeting GATA6. ChIP, luciferase reporter assay, siRNA/overexpression, tumorigenicity assay, miR-363 overexpression Scientific reports Medium 26387746
2016 GATA6 inhibits EMT in pancreatic cancer cells with a direct pro-epithelial, anti-mesenchymal transcriptional function; ChIP-seq and RNA-seq define direct GATA6 transcriptional targets in EMT regulation, and GATA6 loss in vivo promotes cell dissemination. ChIP-seq, RNA-seq, GATA6 silencing and overexpression in PDAC cell lines, in vivo dissemination assay Gut High 27325420
2016 GATA4 and GATA6 maintain pancreatic endoderm identity by repressing hedgehog signaling; pDKO embryos show ectopic Shh pathway activation and transition to intestinal/stomach lineages. GATA4 and GATA6 directly repress transcription through the Shh endoderm-specific enhancer MACS1, and GATA-binding sites within this enhancer are necessary for repression. Conditional double KO (Pdx1-Cre), ChIP, reporter assay with GATA-binding site mutations, lineage marker analysis Development (Cambridge, England) High 26932670
2016 GATA6 controls the sebaceous duct (SD) lineage identity in the epidermis and specifies a lineage switch between sebocytes and SD cells; during wound healing, differentiated Gata6+ cells migrate from the SD into the interfollicular epidermis, dedifferentiate, and acquire long-term self-renewal capacity and broader lineage potential. Gata6 conditional knockout, live imaging, lineage tracing, wound healing model, clonal analysis Nature cell biology High 28504705
2017 GATA6 controls insulin biosynthesis and secretion in adult β-cells; pancreas-specific Gata6-KO mice develop glucose intolerance with decreased insulin content, impaired secretion, ultrastructural abnormalities (immature granules, swollen mitochondria), and GATA6 loss greatly affects β-cell-specific gene expression including Pdx1 (regulated via GATA sites in Pdx1 transgenic reporter mice). Pancreas-specific Gata6 conditional KO, glucose tolerance test, electron microscopy, transgenic Pdx1 reporter, gene expression analysis Diabetes High 29263149
2017 GATA6 and Sp1 cooperate to activate Aqp5 transcription in alveolar epithelial cells through histone H3 acetylation; HDAC3 competes with GATA6 for binding to Sp1, reducing H3 acetylation. Knockdown of GATA6 or its co-activator p300 decreases AQP5 expression; HDAC3 knockdown increases GATA6/Sp1/p300 interactions and H3 acetylation at the Aqp5 promoter. ChIP, co-immunoprecipitation, siRNA knockdown, HDAC inhibitor treatment, reporter assay, Western blot Scientific reports High 28615712
2018 GATA6 is phosphorylated by Erk1/2 at a conserved serine residue (S264); this phosphorylation is required for GATA6 to activate its own promoter and drive a positive feedback loop committing cells to primitive endoderm (PrE) differentiation. S264 mutation drastically impairs GATA6's ability to activate the Gata6 promoter and exit pluripotency. Phosphorylation-deficient mutant (S264A), promoter activation assay in ES cells, Gata6-H2BGFP knock-in reporter mouse Developmental biology High 29454706
2018 Gata6 haploinsufficiency causes right-left type bicuspid aortic valve (BAV) in mice by disrupting valve remodeling and extracellular matrix composition through dysregulation of MMP9. Cell-specific Gata6 deletion identifies an essential role in secondary heart field (Isl1-positive) myocytes, but not in endothelial or neural crest cells, for BAV phenotype. Gata6 heterozygous mice, cell-specific Cre deletion (Isl1-, endothelial-, neural crest-Cre), MMP9 expression analysis, cardiac structure assessment, human BAV genetics Circulation High 29567669
2018 GATA6 directly activates the BMPR2 promoter in vascular smooth muscle cells; TWIST1 promotes GATA-6 protein degradation, reducing GATA-6 occupancy at the BMPR2 promoter and decreasing BMPR2 expression, thereby driving SMC proliferation in pulmonary hypertension. Mass spectrometry, immunoprecipitation, ChIP, TWIST1-deficient mice and siRNA, SMC proliferation assays, pulmonary hypertension rodent models American journal of respiratory and critical care medicine High 32692930
2018 GATA6 is required for SULT2A1 transcription in the adrenal gland; GATA6 and SF1 each bind distinct cis-regulatory elements in the SULT2A1 promoter and are both positive regulators, as shown by deletion/mutation analysis and EMSA. Transient transfection with deleted/mutated SULT2A1 promoter constructs, EMSA, quantitative RT-PCR Molecular endocrinology (Baltimore, Md.) Medium 15388788
2019 GATA6 cooperates with EOMES/SMAD2/3 to regulate cardinal endoderm genes and human definitive endoderm (DE) formation; GATA6-null hPSCs fail to enter the DE lineage, while heterozygous hPSCs show reduced DE. Genome-wide ChIP studies show GATA6 co-occupancy with EOMES/SMAD2/3 at endoderm enhancers, identifying GATA6 as a gatekeeper of human (but not murine) pancreatic ontogeny. Gene-edited and patient-derived hPSCs, directed differentiation, ChIP-seq, RNA-seq, GATA6 KO and heterozygous cell lines Stem cell reports High 30629940
2019 GATA6 directly activates miR-520b transcription in gastric cancer cells (validated by luciferase reporter and ChIP); miR-520b in turn directly targets CREB1, and the GATA6/miR-520b/CREB1 axis suppresses GC cell migration, invasion, and metastasis. ChIP, luciferase reporter assay, overexpression/silencing, in vitro migration/invasion assays, in vivo metastasis model Cell death & disease Medium 30674866
2019 GATA6 physically interacts with LOXL2 (via LOXL2's scavenger receptor cysteine-rich domain) in cholangiocarcinoma cells; the GATA6/LOXL2 complex regulates VEGFA mRNA expression and protein secretion, promoting tube formation and angiogenesis. Co-immunoprecipitation, domain mapping, Western blot, ELISA, tube formation assay, xenograft International journal of oncology Medium 31322171
2019 GATA6 promotes EMT in cholangiocarcinoma through the MUC1/β-catenin pathway; ChIP-seq and luciferase/point-mutant assays show GATA6 binds two specific GATA-motifs in the MUC1 promoter to upregulate MUC1, which then binds β-catenin (shown by co-IP) and increases nuclear β-catenin levels to drive EMT. ChIP-seq, luciferase reporter with point mutations, co-immunoprecipitation, siRNA knockdown/overexpression, in vivo xenograft Cell death & disease High 33060563
2020 GATA6 is a pioneer factor in cardiac development that regulates SMYD1 (which activates HAND2) and KDR; together HAND2 and KDR orchestrate outflow tract formation. Loss-of-function GATA6 variants perturb cardiac and endoderm/pancreatic genes; an exon 4 missense variant causes ectopic pioneer activities, profoundly diminishing GATA4, FOXA1/2, and PDX1 expression. Isogenic hiPSC cardiomyocyte differentiation, ATAC-seq (chromatin accessibility), RNA-seq, ChIP-seq, patient-derived iPSCs with GATA6 variants eLife High 33054971
2020 EZH2 transcriptionally represses GATA6 in pancreatic cancer through histone methylation; pharmacological or genetic EZH2 depletion increases GATA6 expression, inducing a classical PDAC gene signature and reducing invasiveness. Abrogation of GATA6 in EZH2-deficient cells counteracts classical signature acquisition and rescues invasive capacity. RNA-seq, ChIP-seq, transgenic PDAC mouse models, pharmacologic EZH2 inhibition, GATA6 KD rescue experiments Cancer research High 32907838
2020 GATA6 directly represses VEGF-C transcription by binding to the VEGF-C promoter in bladder cancer cells; loss of GATA6 (via promoter hypermethylation) de-represses VEGF-C, promoting lymphangiogenesis and lymph node metastasis. ChIP (GATA6 binding to VEGF-C promoter), promoter methylation analysis, siRNA/overexpression, lymphangiogenesis assay, in vivo lymph node metastasis model FASEB journal Medium 32103545
2020 GATA6 is essential for synthesis of the steroidogenic enzymes HSD3B2, CYP17A1, and CYP19A1 in endometriotic stromal cells; GATA6 alone is necessary but not sufficient for estrogen production, but simultaneous expression of GATA6 and NR5A1 is required and sufficient to convert normal endometrial stromal cells into estrogen-producing endometriotic-like cells. Ectopic expression (GATA6, NR5A1, alone and combined), siRNA silencing, mRNA/protein analysis, estradiol production assay Reproductive sciences (Thousand Oaks, Calif.) Medium 29402198
2020 GATA6 controls keratinocyte proliferation and differentiation in the upper pilosebaceous unit; overexpression in human sebocytes triggers junctional zone and sebaceous differentiation, limits lipid production, modulates immunological repertoire (upregulating PD-L1 and IL10), and mediates TGFβ signaling to suppress infundibular differentiation in sebaceous organoids. GATA6 overexpression in immortalized human sebocytes, human sebaceous organoid model, gene expression analysis, flow cytometry Nature communications High 33082341
2020 GATA6 directly upregulates CD137L (TNFSF9) expression in cutaneous T-cell lymphoma; ChIP, luciferase reporter assay, and shRNA knockdown demonstrate that DNA hypomethylation and histone acetylation induce GATA6 overexpression, which then directly drives CD137L transcription promoting tumor growth. ChIP, luciferase reporter assay, shRNA knockdown, methylation analysis, histone acetylation analysis, in vivo xenograft Blood High 30194255
2021 TET2 drives 5-hydroxymethylcytosine (5hmc) marking of the GATA6 locus in classical PDAC; SMAD4 directly supports TET2 levels, and loss of SMAD4 reduces 5hmc at GATA6, leading to its epigenetic silencing and squamous-like subtype. Restoring TET2 stability (via metformin/ascorbic acid) restores 5hmc and GATA6 levels, reverting squamous-like phenotypes in vitro and in vivo. Oxidative bisulfite sequencing (genome-wide 5hmc mapping), transcriptome analysis, in vivo tumor models, pharmacological TET2 stabilization Gastroenterology High 33915173
2021 Fibroblast GATA-4 and GATA-6 together promote myocardial capillarization (angiogenesis) during pressure overload; double deletion of Gata4/Gata6 in stress-activated fibroblasts (not single deletion) reduces capillary density, and RNA-seq reveals upregulation of anti-angiogenic genes; siRNA knockdown of those genes restores endothelial cell growth in co-culture. Stress-activated fibroblast-specific conditional double KO, pressure overload model, RNA-seq, in vitro fibroblast-endothelial co-culture, siRNA Basic research in cardiology High 33876316
2022 NANOG and GATA6 co-bind at the vast majority of epiblast and primitive endoderm enhancers (both in ES cells and in blastocysts); upon GATA6 induction, eviction of epiblast TFs and rapid chromatin remodeling and enhancer-promoter contact remodeling establishes the PrE lineage while repressing the epiblast fate. Co-binding maintains ICM plasticity. GATA6 induction in ES cells, ChIP-seq (GATA6 and NANOG), ATAC-seq, Hi-C/enhancer-promoter contact analysis, blastocyst immunostaining Nature communications High 35871075
2022 EP300 (p300) histone acetyltransferase directly regulates GATA6 expression in pancreatic cancer; EP300 loss downregulates GATA6, silencing the GATA6-dependent differentiation program and converting classical to basal-like/squamous PDAC subtype, driving resistance to Wnt inhibition (PORCN inhibitors). In vivo CRISPR screen, RNF43-mutant pancreatic cancer xenografts, EP300 knockout/silencing, GATA6 expression analysis, PORCN inhibitor treatment The Journal of clinical investigation High 35536676
2022 GATA6 directly activates GATA6 sinus node target genes TBX3 and EDN1; cell-specific Gata6 deletion in various sinus node lineages reveals requirements in both conduction and non-conduction cells for proper sinus node development and rhythm. Gata6 haploinsufficiency mice, cell-specific Cre deletion (multiple lineages), ChIP/reporter assay for TBX3 and EDN1 direct targets, ECG/rhythm analysis Proceedings of the National Academy of Sciences of the United States of America High 33443158
2022 GATA6 deficiency in intestinal epithelial cells reduces zonula occludens-1 (tight junction) expression, increases intestinal permeability, and triggers a bacteria-driven immune response, demonstrating GATA6 is required for epithelial barrier function. Conditional Gata6 deletion in intestinal epithelium (Gata6del mice), FITC-dextran permeability assay, tight junction protein immunofluorescence, flow cytometry, antibiotic treatment to deplete flora Journal of Crohn's & colitis High 34374415
2023 GATA6 promotes vascular smooth muscle cell senescence and arterial calcification; SIRT6 inhibits GATA6 transcription by deacetylating and increasing degradation of Nkx2.5 (a GATA6 transcriptional activator). GATA6 is induced by DNA damage stress and subsequently impedes ATM-mediated DNA damage repair, leading to accelerated VSMC senescence and osteogenic differentiation. AAV-shRNA knockdown in CKD mice, gain/loss-of-function in vitro, SIRT6-transgenic mice, Nkx2.5 deacetylation assay, ATM pathway analysis Kidney international Medium 37914087
2023 GATA6 is required for brown adipose tissue (BAT) development; GATA6 marks brown adipogenic progenitor cells, and deletion of Gata6 in the brown fat lineage results in a striking loss of BAT. Single-cell gene expression analysis, immunostaining, lineage tracing, Gata6 conditional KO in brown fat lineage Developmental cell High 37647897
2023 Endothelial GATA6 directly activates Cmpk2 and Ccl5 transcription; endothelial Gata6 deletion in hyperlipidemic mice reduces monocyte adherence/migration, decreases pro-inflammatory macrophage foam cell formation (via CMPK2-Nlrp3 pathway), and attenuates atherosclerosis. Endothelial-specific Gata6 KO in ApoEKO mice, ChIP (direct GATA6 binding to Cmpk2 and Ccl5), Icam2-promoter-driven AAV9-shRNA, atherosclerosis lesion quantification Redox biology High 37339559
2012 GATA6 and NF-κB cooperatively activate CPI-17 (PPP1R14A) gene transcription by binding distinct sites on its promoter in bladder smooth muscle cells; GATA6 silencing decreases CPI-17 expression and smooth muscle force maintenance. Promoter characterization, EMSA, ChIP, GATA-6 siRNA, NF-κB knockout mice, smooth muscle strip force assay Molecular and cellular biology High 23275439
2012 GATA6 and FOXA2 directly bind the Wnt6 promoter and are sufficient to activate Wnt6 expression; both factors individually induce primitive endoderm differentiation when overexpressed in F9 cells, concomitantly activating the canonical Wnt/β-catenin pathway (increased TCF-dependent transcription). ChIP, reporter assay (Wnt6 promoter/luciferase), overexpression in F9 teratocarcinoma cells, TCF reporter assay Stem cells and development High 22607194
2019 Gata4 directly represses Gata6 transcription through responsive repressive sites within 1 kb upstream of the Gata6 TSS (identified by ChIP-qPCR and luciferase reporter assay); loss of Gata4 in the second heart field (SHF) leads to enhanced Gata6 expression, indicating a cross-regulatory relationship between these two cardiac GATA factors. ChIP-qPCR, luciferase reporter assay, Gata4 haploinsufficiency mouse model, SHF gene expression analysis PLoS genetics Medium 31120883
2015 Adrenal gland development requires both GATA4 and GATA6; Sf1Cre-mediated double deletion of Gata4 and Gata6 results in absence of identifiable adrenal glands and loss of steroidogenic gene expression. Single Gata6 deletion (Sf1Cre;Gata6 fl/fl) dramatically reduces adrenal size and corticosterone production. Sf1-Cre conditional double KO, histology, steroidogenic gene expression analysis, corticosterone measurement Endocrinology High 25933105
2016 Gata6 protects rapidly proliferating hair follicle matrix progenitors against DNA damage by stimulating EDA-receptor signaling adaptor Edaradd expression and NF-κB pathway activation; Edaradd rescues DNA damage, cell survival, proliferation, and MCM10 expression in Gata6 KO keratinocytes. Conditional Gata6 KO in hair follicle, DNA damage markers, apoptosis assay, Edaradd/NF-κB reporter, keratinocyte culture rescue experiments with Edaradd The EMBO journal Medium 27908934
2019 Mutant Lef1 (β-catenin-independent) directly drives Gata6 expression in sebaceous gland tumors; in mice overexpressing mutant Lef1, Gata6 ablation increases total tumor burden but decreases SG tumors and is associated with impaired DNA mismatch repair (reduced Mlh1 and Msh2). Gata6 overexpression alone (in utero lentiviral injection) is sufficient to induce ectopic SG elements. Mutant Lef1 transgenic mice, Gata6 conditional ablation, in utero lentiviral overexpression, tumor analysis, MLH1/MSH2 expression The EMBO journal High 30886049
2020 GATA6 directly binds the PKM gene promoter and regulates PKM2 transcription in hepatocellular carcinoma cells; GATA6 knockdown elevates glycolytic marker expression and glucose uptake, whereas GATA6 overexpression has opposite effects, demonstrating GATA6 as a transcriptional regulator of metabolic phenotype. ChIP (GATA6 binding to PKM promoter), GATA6 KD/OE, glucose uptake assay, Western blot of glycolytic markers, in vivo xenograft International journal of cancer Medium 30834518
2023 GATA6 transcriptionally activates miR-193b in neurons, which then targets ATG7 to suppress autophagy and ferroptosis; the GATA6/miR-193b/ATG7 axis protects against neuronal death in cerebral ischemia-reperfusion injury models, validated by ChIP and dual-luciferase reporter assays. ChIP, dual-luciferase reporter assay, OGD neuronal model, in vivo MCAO rat model, overexpression/knockdown combinations Neurochemical research Medium 37059928

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1998 GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo. Genes & development 533 9832509
2001 The transcription factors GATA4 and GATA6 regulate cardiomyocyte hypertrophy in vitro and in vivo. The Journal of biological chemistry 300 11356841
2020 GATA6 Expression Distinguishes Classical and Basal-like Subtypes in Advanced Pancreatic Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 273 32156747
2016 GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer. Gut 217 27325420
1997 Expression and hormonal regulation of transcription factors GATA-4 and GATA-6 in the mouse ovary. Endocrinology 179 9231805
2014 GATA6 levels modulate primitive endoderm cell fate choice and timing in the mouse blastocyst. Developmental cell 177 24835466
2014 Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival. The Journal of experimental medicine 171 25024137
1999 Expression and regulation of transcription factors GATA-4 and GATA-6 in developing mouse testis. Endocrinology 169 10067876
2006 A threshold of GATA4 and GATA6 expression is required for cardiovascular development. Proceedings of the National Academy of Sciences of the United States of America 166 16847256
2008 Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development. Developmental biology 159 19084512
2020 miR-196b-5p-mediated downregulation of TSPAN12 and GATA6 promotes tumor progression in non-small cell lung cancer. Proceedings of the National Academy of Sciences of the United States of America 147 32041891
2017 Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties. Nature cell biology 132 28504705
2012 Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis. The Journal of clinical investigation 129 23006325
2012 GATA4 and GATA6 control mouse pancreas organogenesis. The Journal of clinical investigation 125 23006330
2020 HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer. Cell reports 107 32402285
2015 Gata6 potently initiates reprograming of pluripotent and differentiated cells to extraembryonic endoderm stem cells. Genes & development 102 26109048
2003 GATA-6 maintains BMP-4 and Nkx2 expression during cardiomyocyte precursor maturation. The EMBO journal 96 12912923
2010 A novel GATA6 mutation in patients with tetralogy of Fallot or atrial septal defect. Journal of human genetics 95 20631719
2001 A GATA-6 gene heart-region-specific enhancer provides a novel means to mark and probe a discrete component of the mouse cardiac conduction system. Mechanisms of development 88 11578865
2011 GATA5 interacts with GATA4 and GATA6 in outflow tract development. Developmental biology 87 21839733
2014 The miR-363-GATA6-Lgr5 pathway is critical for colorectal tumourigenesis. Nature communications 86 24452072
2008 Genomic profiling identifies GATA6 as a candidate oncogene amplified in pancreatobiliary cancer. PLoS genetics 86 18535672
2015 The acinar regulator Gata6 suppresses KrasG12V-driven pancreatic tumorigenesis in mice. Gut 75 25596178
2008 Dynamic GATA6 expression in primitive endoderm formation and maturation in early mouse embryogenesis. Developmental dynamics : an official publication of the American Association of Anatomists 72 18816845
2018 GATA6 Regulates Aortic Valve Remodeling, and Its Haploinsufficiency Leads to Right-Left Type Bicuspid Aortic Valve. Circulation 71 29567669
2000 GATA-6 activates transcription of surfactant protein A. The Journal of biological chemistry 69 10625644
2020 EZH2 Regulates Pancreatic Cancer Subtype Identity and Tumor Progression via Transcriptional Repression of GATA6. Cancer research 67 32907838
2003 GATA-4 and GATA-6 transcription factors: expression, immunohistochemical localization, and possible function in the porcine ovary. Biology of reproduction 65 12533404
2007 Gata5 and Gata6 are functionally redundant in zebrafish for specification of cardiomyocytes. Developmental biology 63 17950269
2014 GATA4 and GATA6 regulate intestinal epithelial cytodifferentiation during development. Developmental biology 62 24929016
2007 GATA6 is an astrocytoma tumor suppressor gene identified by gene trapping of mouse glioma model. Proceedings of the National Academy of Sciences of the United States of America 61 17463088
2009 Loss of GATA6 leads to nuclear deformation and aneuploidy in ovarian cancer. Molecular and cellular biology 58 19581290
2016 GATA4 and GATA6 regulate pancreatic endoderm identity through inhibition of hedgehog signaling. Development (Cambridge, England) 56 26932670
2004 Steroid sulfotransferase 2A1 gene transcription is regulated by steroidogenic factor 1 and GATA-6 in the human adrenal. Molecular endocrinology (Baltimore, Md.) 53 15388788
2012 MGMT, GATA6, CD81, DR4, and CASP8 gene promoter methylation in glioblastoma. BMC cancer 52 22672670
2020 Contribution of GATA6 to homeostasis of the human upper pilosebaceous unit and acne pathogenesis. Nature communications 51 33082341
2019 Overexpressed lncRNA GATA6-AS1 Inhibits LNM and EMT via FZD4 through the Wnt/β-Catenin Signaling Pathway in GC. Molecular therapy. Nucleic acids 46 31981860
2023 The transcription factor GATA6 accelerates vascular smooth muscle cell senescence-related arterial calcification by counteracting the role of anti-aging factor SIRT6 and impeding DNA damage repair. Kidney international 44 37914087
2020 GATA6 mutations in hiPSCs inform mechanisms for maldevelopment of the heart, pancreas, and diaphragm. eLife 44 33054971
1998 Selection of DNA binding sites for human transcriptional regulator GATA-6. Biochemical and biophysical research communications 43 9784406
2019 GATA6 Cooperates with EOMES/SMAD2/3 to Deploy the Gene Regulatory Network Governing Human Definitive Endoderm and Pancreas Formation. Stem cell reports 42 30629940
2021 TET2 Drives 5hmc Marking of GATA6 and Epigenetically Defines Pancreatic Ductal Adenocarcinoma Transcriptional Subtypes. Gastroenterology 41 33915173
2018 GATA6 loss-of-function mutation contributes to congenital bicuspid aortic valve. Gene 41 29653232
2015 REG4 is a transcriptional target of GATA6 and is essential for colorectal tumorigenesis. Scientific reports 41 26387746
2015 A loss-of-function and H2B-Venus transcriptional reporter allele for Gata6 in mice. BMC developmental biology 40 26498761
2022 Extensive co-binding and rapid redistribution of NANOG and GATA6 during emergence of divergent lineages. Nature communications 39 35871075
2021 Fibroblast GATA-4 and GATA-6 promote myocardial adaptation to pressure overload by enhancing cardiac angiogenesis. Basic research in cardiology 38 33876316
2020 GATA6 promotes epithelial-mesenchymal transition and metastasis through MUC1/β-catenin pathway in cholangiocarcinoma. Cell death & disease 38 33060563
2015 Hypoxia-induced miR-181b enhances angiogenesis of retinoblastoma cells by targeting PDCD10 and GATA6. Oncology reports 38 25872572
2012 GATA6 loss-of-function mutation in atrial fibrillation. European journal of medical genetics 38 22750565
2021 The value of GATA6 immunohistochemistry and computer-assisted diagnosis to predict clinical outcome in advanced pancreatic cancer. Scientific reports 37 34294813
2013 miR-145 inhibits isoproterenol-induced cardiomyocyte hypertrophy by targeting the expression and localization of GATA6. FEBS letters 37 23624080
2016 Gata6 promotes hair follicle progenitor cell renewal by genome maintenance during proliferation. The EMBO journal 36 27908934
2023 Gata6+ large peritoneal macrophages: an evolutionarily conserved sentinel and effector system for infection and injury. Trends in immunology 35 36623953
2018 miR-196b promotes lung cancer cell migration and invasion through the targeting of GATA6. Oncology letters 35 29928408
2018 Aberrant CD137 ligand expression induced by GATA6 overexpression promotes tumor progression in cutaneous T-cell lymphoma. Blood 33 30194255
2007 Adrenocortical tumorigenesis, luteinizing hormone receptor and transcription factors GATA-4 and GATA-6. Molecular and cellular endocrinology 33 17337116
2022 A p300/GATA6 axis determines differentiation and Wnt dependency in pancreatic cancer models. The Journal of clinical investigation 32 35536676
2019 The interaction of LOXL2 with GATA6 induces VEGFA expression and angiogenesis in cholangiocarcinoma. International journal of oncology 32 31322171
2018 The Essential Role of GATA6 in the Activation of Estrogen Synthesis in Endometriosis. Reproductive sciences (Thousand Oaks, Calif.) 32 29402198
2019 GATA6 suppresses migration and metastasis by regulating the miR-520b/CREB1 axis in gastric cancer. Cell death & disease 31 30674866
2014 A novel mutation in GATA6 causes pancreatic agenesis. Pediatric diabetes 31 24433315
2020 TWIST1 Drives Smooth Muscle Cell Proliferation in Pulmonary Hypertension via Loss of GATA-6 and BMPR2. American journal of respiratory and critical care medicine 30 32692930
2020 GATA6-AS1 Regulates GATA6 Expression to Modulate Human Endoderm Differentiation. Stem cell reports 30 32795420
2017 Aberrant GATA2 epigenetic dysregulation induces a GATA2/GATA6 switch in human gastric cancer. Oncogene 29 29106391
2020 Quercetin suppresses migration and invasion by targeting miR-146a/GATA6 axis in fibroblast-like synoviocytes of rheumatoid arthritis. Immunopharmacology and immunotoxicology 28 32216502
2019 Multiple roles and regulatory mechanisms of the transcription factor GATA6 in human cancers. Clinical genetics 28 31437305
2018 GATA6 phosphorylation by Erk1/2 propels exit from pluripotency and commitment to primitive endoderm. Developmental biology 27 29454706
2017 Cell-specific expression of aquaporin-5 (Aqp5) in alveolar epithelium is directed by GATA6/Sp1 via histone acetylation. Scientific reports 27 28615712
2003 Inhibition of alveolarization and altered pulmonary mechanics in mice expressing GATA-6. American journal of physiology. Lung cellular and molecular physiology 27 12909592
2022 GATA6 Deficiency Leads to Epithelial Barrier Dysfunction and Enhances Susceptibility to Gut Inflammation. Journal of Crohn's & colitis 26 34374415
2012 GATA6 and FOXA2 regulate Wnt6 expression during extraembryonic endoderm formation. Stem cells and development 26 22607194
2001 Branching and differentiation defects in pulmonary epithelium with elevated Gata6 expression. Mechanisms of development 26 11429286
2023 Endothelial Gata6 deletion reduces monocyte recruitment and proinflammatory macrophage formation and attenuates atherosclerosis through Cmpk2-Nlrp3 pathways. Redox biology 25 37339559
2022 Viral mediated knockdown of GATA6 in SMA iPSC-derived astrocytes prevents motor neuron loss and microglial activation. Glia 25 35088910
2014 Developmental lung expression and transcriptional regulation of claudin-6 by TTF-1, Gata-6, and FoxA2. Respiratory research 25 24970044
2020 Loss of GATA6 expression promotes lymphatic metastasis in bladder cancer. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 24 32103545
2015 Adrenal Development in Mice Requires GATA4 and GATA6 Transcription Factors. Endocrinology 24 25933105
2019 LncRNA GATA6-AS Promotes Cancer Cell Proliferation and Inhibits Apoptosis in Glioma by Downregulating lncRNA TUG1. Cancer biotherapy & radiopharmaceuticals 23 31809214
2019 Mutant Lef1 controls Gata6 in sebaceous gland development and cancer. The EMBO journal 22 30886049
2017 miR-124 targets GATA6 to suppress cholangiocarcinoma cell invasion and metastasis. BMC cancer 22 28270130
2017 GATA6 Controls Insulin Biosynthesis and Secretion in Adult β-Cells. Diabetes 22 29263149
2015 GATA4 and GATA6 Knockdown During Luteinization Inhibits Progesterone Production and Gonadotropin Responsiveness in the Corpus Luteum of Female Mice. Biology of reproduction 22 26510866
2014 Characterization of the developing small intestine in the absence of either GATA4 or GATA6. BMC research notes 22 25495347
2008 Regulation of the calreticulin gene by GATA6 and Evi-1 transcription factors. Biochemistry 22 18303859
2005 Expression of GATA6 in the human and mouse central nervous system. Brain research. Developmental brain research 22 16150495
2023 Control of murine brown adipocyte development by GATA6. Developmental cell 21 37647897
2020 GATA6 is a regulator of sinus node development and heart rhythm. Proceedings of the National Academy of Sciences of the United States of America 21 33443158
2019 Gata4 regulates hedgehog signaling and Gata6 expression for outflow tract development. PLoS genetics 21 31120883
2019 MicroRNA-203 diminishes the stemness of human colon cancer cells by suppressing GATA6 expression. Journal of cellular physiology 21 31544978
2014 Identification of two novel GATA6 mutations in patients with nonsyndromic conotruncal heart defects. Molecular medicine reports 21 24841381
2022 IGF2BP2 promotes the progression of ovarian endometriosis by regulating m6A-modified MEIS2 and GATA6. The international journal of biochemistry & cell biology 20 36113831
2016 Gain-of-function mutations in GATA6 lead to atrial fibrillation. Heart rhythm 20 27756709
2012 GATA-6 and NF-κB activate CPI-17 gene transcription and regulate Ca2+ sensitization of smooth muscle contraction. Molecular and cellular biology 20 23275439
2020 Metabolic pathways underlying GATA6 regulating Trastuzumab resistance in Gastric Cancer cells based on untargeted metabolomics. International journal of medical sciences 19 33173435
2020 A long non-coding RNA GATA6-AS1 adjacent to GATA6 is required for cardiomyocyte differentiation from human pluripotent stem cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 18 32888237
2019 Deregulated GATA6 modulates stem cell-like properties and metabolic phenotype in hepatocellular carcinoma. International journal of cancer 18 30834518
2019 GATA6-upregulating autophagy promotes TKI resistance in nonsmall cell lung cancer. Cancer biology & therapy 18 31092103
2023 GATA6 Inhibits Neuronal Autophagy and Ferroptosis in Cerebral ischemia-reperfusion Injury Through a miR-193b/ATG7 axis-dependent Mechanism. Neurochemical research 17 37059928
2020 Silencing of long non-coding RNA SOX21-AS1 inhibits lung adenocarcinoma invasion and migration by impairing TSPAN8 via transcription factor GATA6. International journal of biological macromolecules 17 32698071