Affinage

FYCO1

FYVE and coiled-coil domain-containing protein 1 · UniProt Q9BQS8

Length
1478 aa
Mass
167.0 kDa
Annotated
2026-06-09
30 papers in source corpus 19 papers cited in narrative 19 extracted findings
Cross-family judge faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

FYCO1 is a multivalent autophagy adaptor that links autophagosomes and late endosomes to plus end-directed microtubule transport, simultaneously engaging LC3, active Rab7, and PI3P to drive anterograde vesicle movement toward the cell periphery (PMID:20100911). Membrane recruitment is governed by a C-terminally extended F-type LIR motif that selectively binds LC3A/B; crystal structures of the FYCO1 LIR–LC3B complex show that acidic and hydrophobic residues flanking the core tetrapeptide (notably Asp1285 contacting LC3B His57) confer isoform specificity and are required for efficient basal-autophagy autophagosome maturation (PMID:26468287, PMID:28291748). The directionality of this transport is nutrient-tuned: STK4/MST1-mediated phosphorylation of LC3B on Thr50 reduces FYCO1 binding, biasing autophagosomes toward perinuclear lysosomes during starvation (PMID:34146484). Through its C-terminal GOLD domain, FYCO1 binds the CCZ1–MON1A complex that activates RAB7A and is itself cleaved at Asp1306 by activated CASP8, coupling vesicle-to-lysosome transport and death-receptor trafficking to apoptotic signaling (PMID:37418591). Functionally, FYCO1-dependent autophagic transport mediates organelle clearance during lens fiber differentiation—loss-of-function mutations cause autosomal-recessive congenital cataract (PMID:21636066, PMID:35343376)—as well as midbody degradation (PMID:29196475), chromatoid-body/RNP-granule integrity in spermatids (PMID:27929729), stress-induced cardiac autophagy (PMID:33997522), LC3-associated phagosome maturation (PMID:24442442), and Rab7-dependent clearance of α-synuclein aggregates (PMID:29747217).

Mechanistic history

Synthesis pass · year-by-year structured walk · 18 steps
  1. 2010 High

    Established FYCO1 as the molecular bridge coupling autophagosomes to anterograde microtubule transport, answering how these vesicles are positioned within the cell.

    Evidence Co-IP/domain mapping of LC3/Rab7/PI3P-binding regions with knockdown and overexpression live-cell imaging

    PMID:20100911

    Open questions at the time
    • Identity of the kinesin motor engaged was not biochemically resolved
    • Stoichiometry of the LC3/Rab7/PI3P co-recruitment not defined
  2. 2010 Medium

    Proposed that LC3-LIR binding triggers a conformational change exposing the FYVE domain, addressing how FYCO1 achieves selective membrane recruitment.

    Evidence Mechanistic model consolidating domain-mapping data in a commentary

    PMID:20364109

    Open questions at the time
    • No structural or biophysical demonstration of the proposed conformational switch
    • No new experimental data beyond the primary paper
  3. 2011 Medium

    Linked FYCO1 to human disease by showing loss-of-function mutations cause autosomal-recessive congenital cataract, implicating autophagosomal transport in lens biology.

    Evidence Linkage and Sanger sequencing in families plus immunofluorescence localization of WT and p.L1376Pro mutant in lens epithelial cells

    PMID:21636066

    Open questions at the time
    • Mechanism inferred from colocalization without functional rescue
    • How autophagic transport defects produce lens opacity not established
  4. 2014 Medium

    Extended FYCO1 function to LC3-associated phagocytosis, showing it is recruited by LC3 to drive phagosome maturation independent of canonical autophagy.

    Evidence Knockdown/knockout in macrophages with phagosome maturation marker imaging and ROS measurement

    PMID:24442442

    Open questions at the time
    • Single lab
    • Whether Rab7/PI3P engagement is required for phagosomal recruitment not tested
  5. 2015 High

    Defined the structural basis for FYCO1's LC3 selectivity, resolving why it preferentially binds LC3A/B and how this supports basal autophagosome maturation.

    Evidence 1.53 Å crystal structure of FYCO1 LIR–LC3B, peptide-array mutational scanning, and KO cell reconstitution with LIR mutants

    PMID:26468287

    Open questions at the time
    • Why the LIR is dispensable under starvation but required basally not mechanistically explained
  6. 2016 High

    Showed FYCO1 maintains RNP granule integrity in spermatids by recruiting lysosomal vesicles to the chromatoid body via autophagy.

    Evidence Germ cell-specific conditional Fyco1 knockout mice with electron microscopy and autophagy induction assays

    PMID:27929729

    Open questions at the time
    • Molecular tether linking FYCO1 to the chromatoid body not identified
    • Cargo selectivity at the CB unknown
  7. 2017 High

    Independently confirmed flanking-region recognition of the FYCO1 LIR by LC3B and established its conservation across LC3 isoforms and species.

    Evidence X-ray crystallography of mouse LC3B–FYCO1 LIR with structural comparison

    PMID:28291748

    Open questions at the time
    • Does not address in-cell affinity differences among LC3 paralogs
  8. 2017 Medium

    Identified FYCO1 as the mediator of autophagic midbody degradation, connecting its loss to oncogenic phenotypes through midbody accumulation.

    Evidence siRNA knockdown with LC3/midbody imaging, anchorage-independent growth and invadopodia assays

    PMID:29196475

    Open questions at the time
    • Single lab
    • How midbody accumulation mechanistically drives transformation not resolved
  9. 2018 High

    Demonstrated FYCO1 drives Rab7-dependent clearance of α-synuclein aggregates, with epistasis showing the effect requires GTP-bound Rab7.

    Evidence Gain/loss-of-function in mammalian cells, dominant-negative Rab7 epistasis, and a Drosophila A53T-α-synuclein rescue model

    PMID:29747217

    Open questions at the time
    • Whether α-synuclein is captured by direct FYCO1 binding or as bulk cargo not determined
  10. 2021 High

    Revealed a nutrient-sensitive STK4–LC3B–FYCO1 axis in which LC3B-T50 phosphorylation tunes FYCO1 binding to control autophagosome directionality.

    Evidence In vitro binding with phospho-LC3B, T50A mutants, and autophagosome tracking in neurons and cell lines

    PMID:34146484

    Open questions at the time
    • How STK4 activity is spatially coordinated with autophagosomes not defined
    • Quantitative effect on motor engagement unmeasured
  11. 2021 Medium

    Identified the centrosomal protein Nlp as an enhancer of the Rab7–FYCO1 interaction that accelerates autophagic flux.

    Evidence Co-IP, colocalization, autophagic flux assays, and mouse knockout

    PMID:33859171

    Open questions at the time
    • Single lab
    • Direct vs scaffolded interaction with FYCO1 not distinguished
  12. 2021 Medium

    Showed FYCO1 binds α-crystallins and is required to maintain their solubility and autophagic turnover in the lens.

    Evidence Yeast two-hybrid, co-IP, and LC3/p62 immunoblotting in KO mouse eyes

    PMID:34215815

    Open questions at the time
    • Single lab
    • Whether α-crystallin is a direct autophagic cargo of FYCO1 not formally shown
  13. 2021 High

    Established FYCO1 as selectively required for stress-induced (not basal) cardiac autophagy and protective against biomechanical stress.

    Evidence Fyco1 KO and transgenic overexpression mice in pressure-overload/starvation models with cardiomyocyte autophagic flux assays

    PMID:33997522

    Open questions at the time
    • Molecular trigger distinguishing induced from basal autophagy dependence unknown
  14. 2020 Medium

    Determined the high-resolution structure of the FYCO1 RUN domain and modeled possible GTPase interfaces, addressing its potential small-GTPase recognition.

    Evidence 1.3 Å X-ray crystallography with structural comparison and computational docking

    PMID:32744243

    Open questions at the time
    • No binding partner experimentally validated
    • Docking is computational only
  15. 2022 High

    Confirmed in vivo that FYCO1 loss impairs autophagic flux and lens organelle clearance, causally linking the molecular defect to cataractogenesis.

    Evidence Fyco1 KO mice and human lens knock-in cells with TEM and multi-omics profiling

    PMID:35343376

    Open questions at the time
    • Which organelle-clearance step is rate-limiting not pinpointed
  16. 2022 Medium

    Placed FYCO1 upstream of CDC42/N-WASP/Arp2/3 signaling in driving migration, invasion, and EMT, broadening its role beyond vesicle transport.

    Evidence Gain/loss-of-function migration/invasion assays with Arp2/3 inhibitor (CK666) epistasis in HeLa cells

    PMID:36342046

    Open questions at the time
    • Single lab
    • How an autophagy adaptor connects to CDC42 signaling not mechanistically established
  17. 2023 High

    Defined the GOLD domain as a hub coupling FYCO1 to RAB7A-activating CCZ1–MON1A and to CASP8, with cleavage at Asp1306 linking vesicle transport to death-receptor trafficking and apoptosis.

    Evidence Two-step AP-MS, CASP8 cleavage-site mapping, KO/knockdown cells, DISC analysis, and TRAIL apoptosis assays

    PMID:37418591

    Open questions at the time
    • Physiological contexts in which CASP8 cleavage of FYCO1 dominates not defined
    • Whether GOLD-mediated CCZ1–MON1A binding is required for all FYCO1 transport functions untested
  18. 2024 Medium

    Identified a FYCO1–PAK1–p21 axis governing stress-induced senescence in lens epithelial cells.

    Evidence FYCO1 KO cell lines with senescence assays, qRT-PCR, and immunoblot under UVB/H2O2 stress

    PMID:39395618

    Open questions at the time
    • Single lab
    • How FYCO1 regulates PAK1 expression not mechanistically resolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unknown which kinesin motor FYCO1 directly engages and how cargo selectivity (organelles, midbodies, protein aggregates, crystallins) is encoded across its diverse physiological roles.
  • Direct motor partner not biochemically identified
  • Cargo-recognition determinants beyond LC3/Rab7/PI3P not defined
  • Distinction between transport-dependent and signaling roles unresolved

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 3 GO:0008092 cytoskeletal protein binding 1 GO:0008289 lipid binding 1
Localization
GO:0005768 endosome 2 GO:0005856 cytoskeleton 2 GO:0031410 cytoplasmic vesicle 2 GO:0005829 cytosol 1
Pathway
R-HSA-9612973 Autophagy 4 R-HSA-5653656 Vesicle-mediated transport 2 R-HSA-168256 Immune System 1 R-HSA-5357801 Programmed Cell Death 1
Partners
CASP8CCZ1CRYAAMAP1LC3AMAP1LC3BMON1ARAB7ASTK4
Complex memberships
chromatoid body

Evidence

Reading pass · 19 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2010 FYCO1 forms an adaptor complex with LC3, Rab7, and PI3P (phosphatidylinositol-3-phosphate) on autophagosomal membranes to mediate microtubule plus end-directed vesicle transport. FYCO1 depletion causes perinuclear clustering of autophagosomes, while overexpression redistributes Rab7-positive vesicles to the cell periphery. Co-IP/pulldown identification of binding partners, domain mapping of LC3/Rab7/PI3P-binding regions, knockdown and overexpression with live-cell imaging readout The Journal of cell biology High 20100911
2010 A proposed mechanism for selective autophagosomal membrane recruitment of FYCO1 involves a conformational change upon LC3-LIR interaction that exposes the FYVE domain for PI3P binding. Domain binding assays and functional analysis discussed in review/commentary context with reference to original experimental data Autophagy Medium 20364109
2015 FYCO1 contains a C-terminally extended, F-type LIR motif (9 amino acids) that preferentially binds LC3A and LC3B. Crystal structure of FYCO1 LIR peptide–LC3B complex at 1.53 Å resolution revealed that residues at positions 8 (acidic, Asp1285) and 9 (hydrophobic) beyond the core LIR are required for efficient LC3B binding, with Asp1285 contacting His57 of LC3B conferring LC3A/B specificity. A functional LIR motif is required for efficient maturation of autophagosomes under basal (but not starvation-induced) autophagy conditions. Crystal structure determination (1.53 Å), peptide array-based 2D mutational scanning, mutational analysis, FYCO1 knockout cell reconstitution with WT and LIR-mutant constructs The Journal of biological chemistry High 26468287
2017 Crystal structure of mouse LC3B in complex with the FYCO1 LIR peptide confirmed that flanking sequences N-terminal and C-terminal to the core LIR tetrapeptide are specifically recognized by LC3B and contribute to binding, and that this recognition mechanism is conserved across LC3 isoforms and species. X-ray crystallography; structural comparison with related LC3-LIR complexes Acta crystallographica. Section F, Structural biology communications High 28291748
2020 Crystal structure of the FYCO1 RUN domain was determined at 1.3 Å resolution; structural comparisons and docking studies identified possible interaction interfaces with small GTPases of the Ras superfamily, but no binding partner was experimentally confirmed. X-ray crystallography (1.3 Å), structural comparison, computational docking Acta crystallographica. Section F, Structural biology communications Medium 32744243
2011 Loss-of-function mutations in FYCO1 cause autosomal-recessive congenital cataracts. Wild-type and the missense mutant p.L1376Pro FYCO1 expressed in human lens epithelial cells colocalize to autophagosomes and partially to microtubules, consistent with a role in autophagosomal transport in the lens. Human genetics (linkage + Sanger sequencing), immunoblot of truncated mutant proteins, subcellular localization by immunofluorescence in human lens epithelial cells American journal of human genetics Medium 21636066
2014 During LC3-associated phagocytosis, FYCO1 is recruited directly by LC3 to Dectin-1 phagosomes and facilitates maturation of early p40phox+ phagosomes into late LAMP1+ phagosomes. Loss of FYCO1 prolongs p40phox+ phagosome stage and increases reactive oxygen production. FYCO1 knockdown/knockout in macrophages, live imaging and immunofluorescence of phagosome maturation markers, ROS measurement Journal of immunology Medium 24442442
2021 STK4/MST1-mediated phosphorylation of LC3B on threonine 50 (LC3B-T50) reduces FYCO1 binding to LC3B. Impairment of LC3B-T50 phosphorylation (T50A mutation) decreases starvation-induced perinuclear positioning of autophagosomes and their colocalization with lysosomes, and causes aberrant anterograde movement of autophagosomes in neurons and peripheral cells. This defines a nutrient-sensitive STK4–LC3B–FYCO1 axis regulating directional autophagosomal transport. In vitro binding assays with phospho-LC3B, LC3B phosphorylation mutants, autophagosome tracking by live imaging in neurons and cell lines, lysosome colocalization assays Current biology High 34146484
2021 The centrosomal protein Nlp interacts physically with LC3, Rab7, and FYCO1, and enhances the Rab7–FYCO1 interaction, thereby accelerating autophagic flux and autophagolysosome formation. Co-IP, colocalization by immunofluorescence, autophagic flux assays, genetic knockout in mice Signal transduction and targeted therapy Medium 33859171
2018 FYCO1 mediates Rab7-dependent clearance of α-synuclein aggregates. FYCO1-decorated vesicles contained α-synuclein (unlike RILP-decorated vesicles). FYCO1 overexpression reduced α-synuclein aggregate number and protein levels; FYCO1 knockdown reduced Rab7-induced aggregate clearance. The effect of FYCO1 required active (GTP-bound) Rab7, as dominant-negative Rab7 blocked FYCO1-mediated clearance. FYCO1 coexpression in a Drosophila A53T-α-synuclein model reduced aggregates and rescued locomotor deficits. Live-cell imaging, western blot, siRNA knockdown, dominant-negative Rab7, Trypan blue viability, time-lapse microscopy, Drosophila model with filter trap assay and locomotor assay Journal of neurochemistry High 29747217
2016 FYCO1 is a component of the chromatoid body (CB) in haploid round spermatids. Autophagy induction recruits lysosomal vesicles to the CB in a FYCO1-dependent manner; in germ cell-specific Fyco1 conditional knockout mice, this recruitment is lost and the CB becomes fragmented, indicating FYCO1-mediated autophagy regulates RNP granule integrity. Germ cell-specific conditional Fyco1 knockout mouse model, electron microscopy, immunofluorescence, autophagy induction assays Autophagy High 27929729
2017 FYCO1 is responsible for formation of LC3-containing membrane around post-mitotic midbodies and regulates midbody degradation by autophagy. FYCO1 knockdown increases midbody accumulation, which in turn promotes anchorage-independent growth and invadopodia formation in HeLa and squamous carcinoma cells. FYCO1 siRNA knockdown, immunofluorescence for LC3/midbody markers, midbody accumulation quantification, anchorage-independent growth assay, invadopodia assay Journal of cell science Medium 29196475
2022 Loss of FYCO1 in fyco1 knockout mice results in diminished autophagic flux, impaired organelle removal (organelles accumulate in the organelle-free zone of the lens), and cataractogenesis, confirming FYCO1's role in lens fiber cell differentiation via autophagy-dependent organelle clearance. Fyco1 knockout mice, flow cytometry of autophagic flux in FYCO1 knock-in human lens epithelial cells, transmission electron microscopy of lens organoids and mouse lenses, transcriptome/proteome/metabolome profiling Autophagy High 35343376
2021 FYCO1 interacts with αA- and αB-crystallin (identified by yeast two-hybrid and confirmed by co-immunoprecipitation). In FYCO1 knockout mice, soluble αA- and αB-crystallin decrease, LC3-I to LC3-II conversion is reduced, and p62 accumulates, suggesting FYCO1 recruits damaged α-crystallin into autophagosomes. Yeast two-hybrid screening, co-immunoprecipitation, immunoblot of LC3-I/LC3-II conversion and p62 in KO mouse eyes Scientific reports Medium 34215815
2023 FYCO1 interacts with activated CASP8 (caspase 8) via its C-terminal GOLD domain and is a specific CASP8 substrate cleaved at aspartate 1306, releasing the GOLD domain and inactivating FYCO1. FYCO1 also interacts via its GOLD domain with the CCZ1–MON1A complex required for RAB7A activation and vesicle-lysosome fusion. Loss of FYCO1 impairs TNFRSF10B/TRAIL-R2 transport to lysosomes and stabilizes the DISC, sensitizing cells to TRAIL-induced apoptosis. Two-step Co-IP/affinity purification–mass spectrometry (AP-MS), CASP8 cleavage site mapping, FYCO1 KO and knockdown cell lines, DISC complex analysis, receptor trafficking assays, flow cytometry of apoptosis Autophagy High 37418591
2021 FYCO1 is required for autophagy induction (but not basal autophagy) in cardiomyocytes in response to glucose deprivation. Fyco1-deficient mice subjected to starvation or pressure overload cannot induce autophagy and develop impaired cardiac function. FYCO1 overexpression induces autophagy in cardiomyocytes and rescues cardiac dysfunction under biomechanical stress. Fyco1 knockout mice with pressure-overload and starvation models, FYCO1 transgenic overexpression mice, autophagic flux measurement in isolated cardiomyocytes, cardiac function assessment JACC. Basic to translational science High 33997522
2022 FYCO1 promotes migration, invasion, invadopodia formation, and epithelial-mesenchymal transition in HeLa cells through the CDC42/N-WASP/Arp2/3 signaling pathway, as demonstrated by pharmacological inhibition of Arp2/3 with CK666 blocking FYCO1-dependent migration and invasion. FYCO1 overexpression/knockdown, wound healing assay, transwell invasion assay, immunofluorescence for invadopodia, western blot, Arp2/3 inhibitor (CK666) epistasis Biochemistry and cell biology Medium 36342046
2024 FYCO1 knockout in human lens epithelial cells suppresses H2O2- and UVB-induced senescence and p21 levels by suppressing the expression of PAK1 (p21-activated kinase 1), identifying a FYCO1–PAK1–p21 axis in stress-induced autophagy and senescence in lens epithelial cells. FYCO1 knockout cell lines, CCK8 viability, SA-β-Gal senescence assay, qRT-PCR, western blot, immunofluorescence, UVB/H2O2 stress models Archives of biochemistry and biophysics Medium 39395618
2024 Depletion of FYCO1 did NOT phenocopy protrudin or KIF5 depletion for endosomal tubule fission (ETF), establishing that FYCO1's role in late endosome motility is distinct from KIF5-mediated ETF at ER-endosome contacts. Knockdown epistasis; ETF phenotype (increased endosomal tubulation) was assessed by imaging bioRxiv (preprint)preprint Low bio_10.1101_2024.07.15.602703

Source papers

Stage 0 corpus · 30 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2010 FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport. The Journal of cell biology 514 20100911
2011 Mutations in FYCO1 cause autosomal-recessive congenital cataracts. American journal of human genetics 139 21636066
2015 FYCO1 Contains a C-terminally Extended, LC3A/B-preferring LC3-interacting Region (LIR) Motif Required for Efficient Maturation of Autophagosomes during Basal Autophagy. The Journal of biological chemistry 107 26468287
2010 FYCO1: linking autophagosomes to microtubule plus end-directing molecular motors. Autophagy 64 20364109
2014 Cutting edge: FYCO1 recruitment to dectin-1 phagosomes is accelerated by light chain 3 protein and regulates phagosome maturation and reactive oxygen production. Journal of immunology (Baltimore, Md. : 1950) 61 24442442
2021 LC3B phosphorylation regulates FYCO1 binding and directional transport of autophagosomes. Current biology : CB 46 34146484
2021 Nlp promotes autophagy through facilitating the interaction of Rab7 and FYCO1. Signal transduction and targeted therapy 23 33859171
2017 The crystal structure of mouse LC3B in complex with the FYCO1 LIR reveals the importance of the flanking region of the LIR motif. Acta crystallographica. Section F, Structural biology communications 22 28291748
2022 The role of FYCO1-dependent autophagy in lens fiber cell differentiation. Autophagy 21 35343376
2018 FYCO1 mediates clearance of α-synuclein aggregates through a Rab7-dependent mechanism. Journal of neurochemistry 20 29747217
2021 Loss of FYCO1 leads to cataract formation. Scientific reports 19 34215815
2016 FYCO1 and autophagy control the integrity of the haploid male germ cell-specific RNP granules. Autophagy 18 27929729
2023 The autophagic protein FYCO1 controls TNFRSF10/TRAIL receptor induced apoptosis and is inactivated by CASP8 (caspase 8). Autophagy 17 37418591
2021 FYCO1 Regulates Cardiomyocyte Autophagy and Prevents Heart Failure Due to Pressure Overload In Vivo. JACC. Basic to translational science 17 33997522
2017 FYCO1 regulates accumulation of post-mitotic midbodies by mediating LC3-dependent midbody degradation. Journal of cell science 17 29196475
2020 Mutations in FYCO1 identified in families with congenital cataracts. Molecular vision 15 32355443
2021 Autosomal recessive cataract (CTRCT18) in the Yakut population isolate of Eastern Siberia: a novel founder variant in the FYCO1 gene. European journal of human genetics : EJHG 11 33767456
2022 FYCO1 regulates migration, invasion, and invadopodia formation in HeLa cells through CDC42/N-WASP/Arp2/3 signaling pathway. Biochemistry and cell biology = Biochimie et biologie cellulaire 8 36342046
2024 FYCO1 regulates autophagy and senescence via PAK1/p21 in cataract. Archives of biochemistry and biophysics 7 39395618
2023 GWAS reveals genetic basis of a predisposition to severe COVID-19 through in silico modeling of the FYCO1 protein. Frontiers in medicine 6 37547597
2022 FYCO1 Frameshift Deletion in Wirehaired Pointing Griffon Dogs with Juvenile Cataract. Genes 5 35205377
2020 Crystal structure of the FYCO1 RUN domain suggests possible interfaces with small GTPases. Acta crystallographica. Section F, Structural biology communications 5 32744243
2021 Identification of a novel nonsense variant in FYCO1 gene associated with infantile cataract and cortical atrophy. Ophthalmic genetics 4 34282983
2025 FYCO1 Peptide Analogs: Design and Characterization of Autophagy Inhibitors as Co-Adjuvants in Taxane Chemotherapy of Prostate Cancer. International journal of molecular sciences 3 40508175
2022 Targeted gene sequencing of FYCO1 identified a novel mutation in a Pakistani family for autosomal recessive congenital cataract. Molecular genetics & genomic medicine 3 35638468
2022 FYCO1 Increase and Effect of Arimoclomol-Treatment in Human VCP-Pathology. Biomedicines 3 36289705
2024 Construction of an exosome-associated miRNA-mRNA regulatory network and validation of FYCO1 and miR-17-5p as potential biomarkers associated with ovarian cancer. Translational cancer research 2 38482429
2023 Identification and Functional Characterization of Mutation in FYCO1 in Families with Congenital Cataract. Life (Basel, Switzerland) 2 37629644
2022 Two New Variants in FYCO1 Are Responsible for Autosomal Recessive Congenital Cataract in Iranian Population. Cell journal 2 36274208
2022 A Novel Mutation in the FYCO1 Gene Causing Congenital Cataract: Case Study of a Chinese Family. Disease markers 1 36061348

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