Affinage

FBL

rRNA 2'-O-methyltransferase fibrillarin · UniProt P22087

Length
321 aa
Mass
33.8 kDa
Annotated
2026-06-09
100 papers in source corpus 6 papers cited in narrative 6 extracted findings
Cross-family judge vs UniProt: tie faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

Fibrillarin (FBL/NOP1) is an essential nucleolar protein required for the methylation and processing of pre-rRNA en route to mature ribosomes, a function conserved from yeast to mammals (PMID:1825809). Conditional depletion of the yeast ortholog progressively blocks all pre-rRNA processing steps, impairs pre-rRNA methylation, and arrests cytoplasmic ribosome production while leaving snoRNA nucleolar localization intact (PMID:1825809). FBL is targeted to its site of action by its N-terminal glycine-arginine-rich (GAR) domain, which acts as both a nuclear and nucleolar localization signal; arginine methylation within this domain drives nuclear import while reducing nucleolar retention efficiency (PMID:32377452). Beyond directing localization, FBL's phase separation-competent domains nucleate nucleolar condensate assembly and early pre-rRNA processing (efflux, cleavage, and methylation), and in acute myeloid leukemia this activity—rather than its methyltransferase function—enhances oncogene translation, including MYC, to sustain cell survival (PMID:38745030). FBL abundance is set post-transcriptionally: in C. elegans a let-7–NCL-1 cascade translationally represses fibrillarin to control nucleolar size in proportion to the rRNA pool (PMID:26492166). FBL also acts outside ribosome biogenesis to promote DNA damage resistance, physically interacting with YBX1 and enhancing its binding at the BRCA1 promoter to drive BRCA1 transcription and homologous recombination repair (PMID:37489617).

Mechanistic history

Synthesis pass · year-by-year structured walk · 6 steps
  1. 1990 Medium

    Establishing that the yeast NOP1 gene encodes a single-copy nucleolar protein structurally homologous to mammalian fibrillarin defined the molecular identity and conserved GAR-domain architecture of the protein.

    Evidence Gene isolation, DNA sequencing, and protein alignment with cross-reactivity to scleroderma serum in yeast

    PMID:2298745

    Open questions at the time
    • Sequence homology alone did not establish the GAR domain's functional role
    • No enzymatic or processing function demonstrated at this stage
  2. 1991 High

    Conditional depletion answered what NOP1/fibrillarin does mechanistically, showing it is required for both pre-rRNA methylation and all pre-rRNA processing steps that yield mature rRNA.

    Evidence GAL-promoter conditional depletion with pulse-chase labeling, Northern hybridization, methylation assay, and subnuclear fractionation in yeast

    PMID:1825809

    Open questions at the time
    • Did not resolve whether methylation defect causes the processing defect or vice versa
    • Catalytic mechanism of methylation not defined
    • Findings in yeast, not directly in human cells
  3. 2015 High

    Genetic epistasis in C. elegans established how fibrillarin abundance is regulated, placing it downstream of a let-7–NCL-1 translational repression cascade that couples FBL levels to nucleolar size and rRNA pool.

    Evidence Loss-of-function epistasis, translation and 3'UTR reporter assays, and nucleolar size measurement in C. elegans

    PMID:26492166

    Open questions at the time
    • Conservation of the let-7–NCL-1–FBL cascade in mammals not demonstrated
    • Does not address direct molecular function of fibrillarin protein
  4. 2020 Medium

    Dissecting the GAR domain answered how FBL reaches the nucleolus, showing it serves as a dual nuclear/nucleolar localization signal whose arginine methylation favors import but disfavors retention.

    Evidence Deletion and point mutants, subcellular fractionation, live-cell imaging, and arginine-methylation inhibition in eukaryotic cells

    PMID:32377452

    Open questions at the time
    • Single lab; import machinery recognizing the GAR-NLS not identified
    • Quantitative balance between import and retention not fully resolved
  5. 2023 Medium

    A non-canonical role was uncovered: FBL acts in the DNA damage response by interacting with YBX1 to drive BRCA1 transcription and homologous recombination, linking it to crosslinker resistance in cancer.

    Evidence Co-IP, FBL knockdown in cells and xenografts, ChIP at the BRCA1 promoter, comet and HR repair assays

    PMID:37489617

    Open questions at the time
    • Single-lab Co-IP without reciprocal structural mapping of the FBL–YBX1 interface
    • Mechanism by which FBL increases nuclear YBX1 accumulation unclear
    • Whether this function depends on nucleolar localization or methyltransferase activity not resolved
  6. 2024 High

    Domain-specific functional dissection showed that FBL's phase separation domains, not its catalytic domains, drive nucleolar condensate formation and oncogene translation, identifying a druggable vulnerability in AML.

    Evidence In vivo CRISPR RBP screen, domain-mutant rescue, phase separation and pre-rRNA processing assays, polysome profiling, and pharmacological inhibition with CGX-635

    PMID:38745030

    Open questions at the time
    • Relationship between phase separation and the conserved methyltransferase/processing role not fully reconciled
    • Selectivity and on-target mechanism of CGX-635 in normal cells not defined

Open questions

Synthesis pass · forward-looking unresolved questions
  • How FBL's distinct activities—2'-O-methylation, condensate-driven processing, localization control, and the YBX1/BRCA1 transcriptional role—are integrated and regulated within a single protein remains unresolved.
  • No structural model integrating GAR localization, catalytic, and phase-separation functions
  • Whether the DNA-damage role requires catalytic or condensate activity is unknown
  • Mammalian regulation of FBL abundance not directly characterized in the corpus

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 2 GO:0140098 catalytic activity, acting on RNA 1
Localization
GO:0005730 nucleolus 4 GO:0005634 nucleus 1
Pathway
R-HSA-8953854 Metabolism of RNA 2 R-HSA-73894 DNA Repair 1
Partners
YBX1

Evidence

Reading pass · 6 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1991 Yeast NOP1 (fibrillarin ortholog) is required for pre-rRNA processing: conditional depletion of NOP1 progressively impairs all pre-rRNA processing steps (particularly the pathway leading to 18S rRNA) and concomitantly impairs pre-rRNA methylation, causing accumulation of unmethylated, unprocessed pre-rRNA. NOP1 depletion blocks cytoplasmic ribosome production without preventing nucleolar localization of snoRNAs. Conditional depletion via GAL promoter replacement, pulse-chase labeling of pre-rRNA, Northern hybridization, subnuclear fractionation, immunocytochemistry The EMBO journal High 1825809
1990 Yeast NOP1/p38 encodes a nucleolar protein with an N-terminal glycine-arginine-rich (GAR) repetitive motif homologous to mammalian fibrillarin and nucleolin; the protein contains a putative nuclear localization signal and is the product of a single-copy gene. Gene isolation, DNA sequencing, Northern blot, protein sequence alignment, immunoreactivity with scleroderma patient serum The Journal of biological chemistry Medium 2298745
2015 In C. elegans, fibrillarin (FIB-1) abundance is translationally repressed by NCL-1 (in cooperation with PUF and NOS RNA-binding proteins), and NCL-1 is itself inhibited by the microRNA let-7. This let-7–ncl-1–fib-1 genetic cascade controls nucleolar size and rRNA pool: loss-of-function of fib-1 reduces nucleolar size, while its overexpression increases nucleolar size correlated with rRNA levels. Loss-of-function genetic epistasis analysis, translation reporter assays, 3′UTR binding assays, nucleolar size measurement PLoS genetics High 26492166
2020 The N-terminal glycine-arginine-rich (GAR) domain of fibrillarin (FBL) functions as both a nuclear localization signal (NLS) and a nucleolar localization signal (NoLS). Arginine methylation within the GAR domain is required for nuclear import but decreases efficiency of nucleolar retention. Deletion or mutation of the GAR domain mislocalizes FBL. Deletion and point mutant constructs of FBL expressed in eukaryotic cells, subcellular fractionation, live-cell fluorescence microscopy, arginine methylation inhibition PeerJ Medium 32377452
2023 FBL (fibrillarin) promotes DNA damage response and resistance to DNA crosslinking agents in cancer cells. FBL physically interacts with Y-box-binding protein 1 (YBX1) and increases nuclear accumulation of YBX1 upon DNA damage. FBL promotes BRCA1 transcription by enhancing YBX1 binding to the BRCA1 promoter. FBL knockdown sensitizes tumor cells to DNA crosslinking agents and causes homologous recombination repair defects. Co-immunoprecipitation (Co-IP) of FBL–YBX1 interaction, FBL knockdown in cell lines and xenografts, ChIP assay for YBX1 at BRCA1 promoter, comet assay and HR repair assays EMBO reports Medium 37489617
2024 FBL (fibrillarin) drives AML cell survival primarily through its phase separation (PS) domains rather than its methyltransferase or acetylation domains. Phase separation-competent FBL promotes nucleolar condensate formation, early pre-rRNA processing steps (efflux, cleavage, and methylation), and ultimately enhances translation of oncogenes including MYC. Targeting FBL phase separation with CGX-635 eliminates AML cells. In vivo CRISPR RBP screen, domain-specific mutant rescue experiments, phase separation assays, pre-rRNA processing assays, polysome profiling/translation assays, pharmacological inhibition with CGX-635 Nature cell biology High 38745030

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1991 The small nucleolar RNP protein NOP1 (fibrillarin) is required for pre-rRNA processing in yeast. The EMBO journal 318 1825809
2017 Enhanced FIB-SEM systems for large-volume 3D imaging. eLife 286 28500755
2023 Using the ELF test, FIB-4 and NAFLD fibrosis score to screen the population for liver disease. Journal of hepatology 189 37088311
2019 A cryo-FIB lift-out technique enables molecular-resolution cryo-ET within native Caenorhabditis elegans tissue. Nature methods 178 31363205
1999 A eukaryotic protein, NOP-1, binds retinal to form an archaeal rhodopsin-like photochemically reactive pigment. Biochemistry 123 10571987
1996 Identification of a gag-encoded cytotoxic T-lymphocyte epitope from FBL-3 leukemia shared by Friend, Moloney, and Rauscher murine leukemia virus-induced tumors. Journal of virology 112 8892898
1990 Isolation and sequencing of NOP1. A yeast gene encoding a nucleolar protein homologous to a human autoimmune antigen. The Journal of biological chemistry 112 2298745
2011 Serial FIB/SEM imaging for quantitative 3D assessment of the osteocyte lacuno-canalicular network. Bone 96 21514408
2021 3D FIB-SEM reconstruction of microtubule-organelle interaction in whole primary mouse β cells. The Journal of cell biology 88 33326005
1989 FBL-reactive CD8+ cytotoxic and CD4+ helper T lymphocytes recognize distinct Friend murine leukemia virus-encoded antigens. The Journal of experimental medicine 77 2562982
2019 PIE-scope, integrated cryo-correlative light and FIB/SEM microscopy. eLife 76 31259689
2019 Impact of Implementing a "FIB-4 First" Strategy on a Pathway for Patients With NAFLD Referred From Primary Care. Hepatology communications 73 31592044
2014 Human cardiac telocytes: 3D imaging by FIB-SEM tomography. Journal of cellular and molecular medicine 71 25327290
2011 Evaluation of liver fibrosis: concordance analysis between noninvasive scores (APRI and FIB-4) evolution and predictors in a cohort of HIV-infected patients without hepatitis C and B infection. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 66 21467023
2012 3D structure determination of native mammalian cells using cryo-FIB and cryo-electron tomography. Journal of structural biology 59 22796867
2009 Molecular characterization of the interaction of staphylococcal microbial surface components recognizing adhesive matrix molecules (MSCRAMM) ClfA and Fbl with fibrinogen. The Journal of biological chemistry 59 20007717
1993 Multiplicity of virus-encoded helper T-cell epitopes expressed on FBL-3 tumor cells. Journal of virology 56 7687300
2020 Elevation of Liver Fibrosis Index FIB-4 Is Associated With Poor Clinical Outcomes in Patients With COVID-19. The Journal of infectious diseases 54 32563190
2017 Pore shape and size dependence on cell growth into electrospun fiber scaffolds for tissue engineering: 2D and 3D analyses using SEM and FIB-SEM tomography. Materials science & engineering. C, Materials for biological applications 54 30573264
2023 Quantification of gallium cryo-FIB milling damage in biological lamellae. Proceedings of the National Academy of Sciences of the United States of America 53 37216561
2020 Liver Fibrosis Index FIB-4 Is Associated With Mortality in COVID-19. Hepatology communications 51 34553511
2009 Comparison of different preparation methods of biological samples for FIB milling and SEM investigation. Journal of microscopy 50 19220697
2004 Characterization of the fibrinogen-binding surface protein Fbl of Staphylococcus lugdunensis. Microbiology (Reading, England) 47 15528668
2020 Crossfibrillar mineral tessellation in normal and Hyp mouse bone as revealed by 3D FIB-SEM microscopy. Journal of structural biology 42 32805412
2018 More than a syllable in fib-ROS-is: The role of ROS on the fibrotic extracellular matrix and on cellular contacts. Molecular aspects of medicine 42 29596842
2009 Regulation and targeted mutation of opsA, coding for the NOP-1 opsin orthologue in Fusarium fujikuroi. Journal of molecular biology 42 19361430
2020 Cryo-FIB-SEM as a promising tool for localizing proteins in 3D. Journal of structural biology 41 32387573
2017 Evolution of Regions Containing Antibiotic Resistance Genes in FII-2-FIB-1 ColV-Colla Virulence Plasmids. Microbial drug resistance (Larchmont, N.Y.) 41 28922058
2010 Gridded Aclar: preparation methods and use for correlative light and electron microscopy of cell monolayers, by TEM and FIB-SEM. Journal of microscopy 41 20096051
2021 Super-resolution confocal cryo-CLEM with cryo-FIB milling for in situ imaging of Deinococcus radiodurans. Current research in structural biology 40 34977598
2013 Mapping the complex morphology of cell interactions with nanowire substrates using FIB-SEM. PloS one 39 23326412
2011 FIB-4 index is associated with hepatocellular carcinoma risk in HIV-infected patients. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 37 22028407
2023 Cryo-plasma FIB/SEM volume imaging of biological specimens. eLife 36 36805107
2017 Gamma-glutamyl-transpeptidase to platelet ratio is not superior to APRI,FIB-4 and RPR for diagnosing liver fibrosis in CHB patients in China. Scientific reports 36 28819319
2015 A Genetic Cascade of let-7-ncl-1-fib-1 Modulates Nucleolar Size and rRNA Pool in Caenorhabditis elegans. PLoS genetics 36 26492166
2021 FIB-SEM as a Volume Electron Microscopy Approach to Study Cellular Architectures in SARS-CoV-2 and Other Viral Infections: A Practical Primer for a Virologist. Viruses 35 33918371
2019 Qualitative Analyses of Polishing and Precoating FIB Milled Crystals for MicroED. Structure (London, England : 1993) 35 31422911
2023 FBL promotes cancer cell resistance to DNA damage and BRCA1 transcription via YBX1. EMBO reports 34 37489617
2010 The efficacy of a NOP1 agonist (SCH486757) in subacute cough. Lung 33 19937046
2005 Hypothalamic cocaine- and amphetamine-regulated transcript (CART) and agouti-related protein (AgRP) neurons coexpress the NOP1 receptor and nociceptin alters CART and AgRP release. Endocrinology 32 15890775
2017 Three-dimensional intracellular structure of a whole rice mesophyll cell observed with FIB-SEM. Annals of botany 31 28444369
2017 Diagnostic value of FIB-4, aspartate aminotransferase-to-platelet ratio index and liver stiffness measurement in hepatitis B virus-infected patients with persistently normal alanine aminotransferase. World journal of gastroenterology 31 28883700
2016 An improved cryo-FIB method for fabrication of frozen hydrated lamella. Journal of structural biology 31 26876148
2024 Degree of Discordance Between FIB-4 and Transient Elastography: An Application of Current Guidelines on General Population Cohort. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 29 38428706
2018 Morphological Processes of Foot Process Effacement in Puromycin Aminonucleoside Nephrosis Revealed by FIB/SEM Tomography. Journal of the American Society of Nephrology : JASN 29 30514724
2018 In situ protein micro-crystal fabrication by cryo-FIB for electron diffraction. Biophysics reports 29 30596142
2015 Correlation of two-photon in vivo imaging and FIB/SEM microscopy. Journal of microscopy 29 25786682
2017 Comparison of FIB-4 index and aspartate aminotransferase to platelet ratio index on carcinogenesis in chronic hepatitis B treated with entecavir. Journal of Cancer 28 28243319
1993 Rejection of an IA+ variant line of FBL-3 leukemia by cytotoxic T lymphocytes with CD4+ and CD4-CD8- T cell receptor-alpha beta phenotypes generated in CD8-depleted C57BL/6 mice. Journal of immunology (Baltimore, Md. : 1950) 27 8496592
1994 Fine structure of a virus-encoded helper T-cell epitope expressed on FBL-3 tumor cells. Journal of virology 26 7525983
2020 Super-Resolution Microscopy and FIB-SEM Imaging Reveal Parental Centriole-Derived, Hybrid Cilium in Mammalian Multiciliated Cells. Developmental cell 25 33038333
2017 Quantification of silver nanoparticle uptake and distribution within individual human macrophages by FIB/SEM slice and view. Journal of nanobiotechnology 23 28327151
2021 Bone metabolism and evolutionary origin of osteocytes: Novel application of FIB-SEM tomography. Science advances 22 33789889
2018 Precise and economic FIB/SEM for CLEM: with 2 nm voxels through mitosis. Histochemistry and cell biology 22 29789992
2022 In situ cryo-FIB/SEM Specimen Preparation Using the Waffle Method. Bio-protocol 21 36618877
2020 Sequential Combination of FIB-4 Followed by M2BPGi Enhanced Diagnostic Performance for Advanced Hepatic Fibrosis in an Average Risk Population. Journal of clinical medicine 21 32295166
2019 Three-dimensional imaging of podocyte ultrastructure using FE-SEM and FIB-SEM tomography. Cell and tissue research 21 31758252
2010 Focused ion beam (FIB)/scanning electron microscopy (SEM) in tissue structural research. Protoplasma 21 20169456
2007 Interaction of the fibronectin COOH-terminal Fib-2 regions with fibrin: further characterization and localization of the Fib-2-binding sites. Biochemistry 21 17425334
2002 The ORL-1 (NOP1) receptor ligand nociceptin/orphanin FQ (N/OFQ) inhibits neurogenic dural vasodilatation in the rat. Neuropharmacology 21 12423668
1995 Incidence of the highly conserved fib gene and expression of the fibrinogen-binding (Fib) protein among clinical isolates of Staphylococcus aureus. Journal of clinical microbiology 21 7494026
2024 Phase separation-competent FBL promotes early pre-rRNA processing and translation in acute myeloid leukaemia. Nature cell biology 20 38745030
2024 Age-dependent differences in FIB-4 predictions of fibrosis in patients with MASLD referred from primary care. Hepatology communications 19 39670870
2023 The reduction of FIB damage on cryo-lamella by lowering energy of ion beam revealed by a quantitative analysis. Structure (London, England : 1993) 19 37527655
2021 In situ fiducial markers for 3D correlative cryo-fluorescence and FIB-SEM imaging. iScience 19 34258551
2020 The GAR domain integrates functions that are necessary for the proper localization of fibrillarin (FBL) inside eukaryotic cells. PeerJ 19 32377452
2022 Examining atherosclerotic lesions in three dimensions at the nanometer scale with cryo-FIB-SEM. Proceedings of the National Academy of Sciences of the United States of America 17 35939716
2022 Evaluation of FIB-4, NFS, APRI and Liver Function Tests as Predictors for SARS-CoV-2 Infection in the Elderly Population: A Matched Case-Control Analysis. Journal of clinical medicine 17 36079087
2021 Correlation of organelle dynamics between light microscopic live imaging and electron microscopic 3D architecture using FIB-SEM. Microscopy (Oxford, England) 17 33216938
2021 FIB-milled plasmonic nanoapertures allow for long trapping times of individual proteins. iScience 17 34746702
2018 The gamma-glutamyl transferase to platelet ratio and the FIB-4 score are noninvasive markers to determine the severity of liver fibrosis in chronic hepatitis B infection. British journal of biomedical science 17 29893189
2018 Comparison of FIB-4 and transient elastography in evaluating liver fibrosis of chronic hepatitis C subjects in community. PloS one 17 30403744
2015 Structural stress responses and degradation of dictyosomes in algae analysed by TEM and FIB-SEM tomography. Journal of microscopy 17 26708415
2009 Detection of Staphylococcus lugdunensis by a new species-specific PCR based on the fbl gene. FEMS immunology and medical microbiology 17 19912343
2021 Upregulation of circ-FBL promotes myogenic proliferation in myasthenia gravis by regulation of miR-133/PAX7. Cell biology international 16 34363272
2020 Cryo-FIB preparation of whole cells and tissue for cryo-TEM: use of high-pressure frozen specimens in tubes and planchets. Journal of microscopy 16 32691851
2011 The monomeric, tetrameric, and fibrillar organization of Fib: the dynamic building block of the bacterial linear motor of Spiroplasma melliferum BC3. Journal of molecular biology 16 21605565
2011 Construction and characterization of three knockout mutants of the fbl gene in Staphylococcus lugdunensis. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 16 22229266
2004 Application of a FIB-STEM system for 3D observation of a resin-embedded yeast cell. Journal of electron microscopy 16 15582966
2003 Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European journal of pharmacology 16 14660000
2020 The geometrical structure of interfaces in dental enamel: A FIB-STEM investigation. Acta biomaterialia 15 31917293
2020 Axonal debris accumulates in corneal epithelial cells after intraepithelial corneal nerves are damaged: A focused Ion Beam Scanning Electron Microscopy (FIB-SEM) study. Experimental eye research 15 32209319
2022 3D FIB-SEM structural insights into the architecture of sub-pellicular microtubules of Trypanosoma cruzi epimastigotes. Biology of the cell 14 35475518
2020 Liver fibrosis assessments using FibroScan, virtual-touch tissue quantification, the FIB-4 index, and mac-2 binding protein glycosylation isomer levels compared with pathological findings of liver resection specimens in patients with hepatitis C infection. BMC gastroenterology 14 32977741
2019 Immunogold FIB-SEM: Combining Volumetric Ultrastructure Visualization with 3D Biomolecular Analysis to Dissect Cell-Environment Interactions. Advanced materials (Deerfield Beach, Fla.) 14 31197896
2015 Seeing a Mycobacterium-Infected Cell in Nanoscale 3D: Correlative Imaging by Light Microscopy and FIB/SEM Tomography. PloS one 14 26406896
2020 Genotypic and Phenotypic Characterization of Incompatibility Group FIB Positive Salmonella enterica Serovar Typhimurium Isolates from Food Animal Sources. Genes 13 33158112
2019 Poly-(γ-glutamic acid) Production and Optimization from Agro-Industrial Bioresources as Renewable Substrates by Bacillus sp. FBL-2 through Response Surface Methodology. Biomolecules 13 31756993
1995 A single retroviral gag precursor signal peptide recognized by FBL-3 tumor-specific cytotoxic T lymphocytes. Journal of virology 13 7474084
1989 Characterization of a CD4(L3T4)-positive cytotoxic T cell clone that is restricted by class I major histocompatibility complex antigen on FBL-3 tumor cell. Immunobiology 13 2483152
2023 Prediction of underlying atrial fibrillation in patients with a cryptogenic stroke: results from the NOR-FIB Study. Journal of neurology 12 37162578
2022 Genomic Characterization of a Uropathogenic Escherichia coli ST405 Isolate Harboring bla CTX-M-15-Encoding IncFIA-FIB Plasmid, bla CTX-M-24-Encoding IncI1 Plasmid, and Phage-Like Plasmid. Frontiers in microbiology 12 35479623
2022 Liver fibrosis progression in a cohort of young HIV and HIV/ HBV co-infected patients: A longitudinal study using non-invasive APRI and Fib-4 scores. Frontiers in medicine 12 35966860
2022 Hybrid IncFIA/FIB/FIC(FII) plasmid co-carrying blaNDM-5 and fosA3 from an Escherichia coli ST117 strain of retail chicken. International journal of food microbiology 12 36088664
2019 Unravelling the ultrastructural details of αT-catenin-deficient cell-cell contacts between heart muscle cells by the use of FIB-SEM. Journal of microscopy 12 31828778
2017 Improving microstructural quantification in FIB/SEM nanotomography. Ultramicroscopy 12 28841458
2017 FIB and MIP: understanding nanoscale porosity in molecularly imprinted polymers via 3D FIB/SEM tomography. Nanoscale 12 28948256
2011 Fbl is not involved in the invasion of eukaryotic epithelial and endothelial cells by Staphylococcus lugdunensis. FEMS microbiology letters 12 22092763
2009 ISG15 expression in response to double-stranded RNA or LPS in cultured Fetal bovine lung (FBL) cells. Veterinary research communications 12 19367472
1999 92K-GL (MMP-9) and 72K-GL (MMP-2) are produced in vivo by human oral squamous cell carcinomas and can enhance FIB-CL (MMP-1) activity in vitro. Journal of dental research 12 10403463

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