Affinage

ANXA5

Annexin A5 · UniProt P08758

Length
320 aa
Mass
35.9 kDa
Annotated
2026-06-09
66 papers in source corpus 18 papers cited in narrative 18 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ANXA5 is a Ca2+-dependent phospholipid-binding annexin that recognizes surface-exposed phosphatidylserine and assembles into ordered two-dimensional arrays on membranes, a property central to its anticoagulant function at the maternal-fetal interface, where it localizes to placental syncytiotrophoblast microvilli (PMID:2534288, PMID:2148197). The 2D-array activity is mechanistically required for its anticoagulant action: recombinant ANXA5 that binds phosphatidylserine but cannot form arrays fails to delay coagulation (PMID:27178140). Its expression is set by transcriptional and post-transcriptional control — the M2 promoter haplotype reduces promoter activity to ~37–42% and lowers allele-specific mRNA in heterozygous placenta, linking reduced ANXA5 to recurrent pregnancy loss, while zinc upregulates and miR-506-3p directly represses ANXA5 (PMID:17339269, PMID:20805002, PMID:29716435, PMID:33354277). Through its phosphatidylserine-targeting and cytoprotective activities, ANXA5 suppresses caspase-dependent apoptosis to confer glucocorticoid resistance in B-ALL cells and activates the ERK/Nrf2/HO-1 antioxidant pathway (PMID:33231128, PMID:31404886, PMID:33354277). ANXA5 also drives cancer cell proliferation, migration, and invasion via ERK2/c-Jun/E-cadherin signaling, modulates membrane structure and collagen binding in biomineralizing matrix-vesicle mimetics, and participates in mechanical-stress membrane repair (PMID:27697636, PMID:28549727). In endothelial cells, FUS directly binds ANXA5 and sustains its expression downstream of a MIR4697HG/FUS axis to protect against ox-LDL-induced apoptosis (PMID:38082058).

Mechanistic history

Synthesis pass · year-by-year structured walk · 15 steps
  1. 1989 Medium

    Establishing ANXA5's chromosomal locus and family membership defined it as a Ca2+-dependent phospholipid-binding annexin, framing all subsequent membrane-based mechanistic work.

    Evidence Somatic cell hybrid Southern blot and in situ chromosome hybridization mapping to 4q28-q32

    PMID:2534288

    Open questions at the time
    • Mapping alone establishes no biochemical activity
    • No functional data in this study
  2. 1990 Medium

    Localizing ANXA5 to placental syncytiotrophoblast microvilli grounded its proposed anticoagulant role at the maternal-fetal interface in a specific cellular compartment.

    Evidence Immunoelectron microscopy of placental tissue

    PMID:2148197

    Open questions at the time
    • Localization does not demonstrate the anticoagulant mechanism directly
    • Single study
  3. 2007 High

    Reporter assays showed the M2 promoter haplotype reduces ANXA5 transcription, providing a mechanistic link between a common variant and reduced expression associated with recurrent pregnancy loss.

    Evidence Luciferase/CAT reporter assays comparing M2 vs wild-type promoter constructs

    PMID:17339269

    Open questions at the time
    • In vitro promoter activity does not establish the in vivo thrombotic mechanism
    • Does not identify the transcription factors affected
  4. 2010 Medium

    Allele-specific quantification in heterozygous placenta confirmed the M2 effect operates in the functionally relevant organ, not just in reporter constructs.

    Evidence Allele-specific mRNA quantification in human placental tissue

    PMID:20805002

    Open questions at the time
    • Does not measure resulting surface protein coverage in vivo
    • Single lab
  5. 2016 High

    Mutagenesis plus knockout phenotyping established that 2D array formation, not mere phosphatidylserine binding, is the activity underlying ANXA5's anticoagulant action, and that endogenous physiological ANXA5 is dispensable for hemostasis.

    Evidence AnxA5-deficient mouse wound model with recombinant wild-type and array-deficient mutant injection and in vitro coagulation assay

    PMID:27178140

    Open questions at the time
    • Does not resolve the structural basis of array assembly
    • Physiological vs pharmacological roles distinguished only in mouse
  6. 2016 Medium

    Knockdown in hepatocarcinoma cells defined a specific ERK2/c-Jun/E-cadherin axis as the route by which ANXA5 promotes migration and invasion, excluding alternative MAPK and AKT pathways.

    Evidence shRNA knockdown with migration/invasion/adhesion assays and pathway inhibitor dissection

    PMID:27697636

    Open questions at the time
    • Single cell line and single lab
    • Does not link the membrane-binding activity to the signaling output
  7. 2017 Medium

    Biophysical reconstitution showed ANXA5 modulates membrane surface structure and collagen-binding affinity in matrix-vesicle mimetics, extending its function to biomineralization.

    Evidence Atomic force microscopy and collagen-binding assays of TNAP/AnxA5 proteoliposomes

    PMID:28549727

    Open questions at the time
    • In vitro membrane mimetics only
    • Physiological relevance to mineralization not tested in vivo
  8. 2018 Medium

    Zinc was shown to upregulate ANXA5 transcription and surface abundance, identifying a positive regulatory input that can restore anticoagulant function.

    Evidence Cell culture transcription/surface flow cytometry assays and AnxA5-deficient mouse pregnancy model

    PMID:29716435

    Open questions at the time
    • Mouse litter-size effect was a trend, not significant
    • Mechanism of zinc-induced transcription not defined
  9. 2019 Medium

    Gain-of-function with inhibitor rescue placed ANXA5 upstream of ERK-dependent Nrf2/HO-1/NQO1 antioxidant signaling, defining a cytoprotective mechanism against oxidative stress.

    Evidence Overexpression in Leydig/Sertoli cells, ROS and oxidative markers, ERK inhibitor rescue

    PMID:31404886

    Open questions at the time
    • Single lab and cell types
    • Does not connect membrane binding to ERK activation
  10. 2019 Medium

    Fusion-protein targeting confirmed ANXA5's phosphatidylserine recognition of hypoxia-injured cells can be exploited as a delivery anchor that reduces apoptosis and improves cardiac function.

    Evidence Binding/competition assays and mouse myocardial infarction model with SDF-1-AnxA5 fusion

    PMID:31468674

    Open questions at the time
    • Therapeutic benefit attributable partly to the SDF-1 cargo
    • Single lab
  11. 2020 Medium

    Identification of miR-506-3p as a direct repressor of ANXA5 mRNA, with recombinant ANXA5 rescue, established post-transcriptional control of the ANXA5/Nrf2/HO-1 antioxidant axis.

    Evidence miRNA agomir overexpression with recombinant ANXA5 rescue in rat testis and cell culture

    PMID:33354277

    Open questions at the time
    • Single lab
    • Does not map the miRNA binding site biochemically beyond reporter inference
  12. 2020 Medium

    ANXA5 silencing sensitizing B-ALL cells to dexamethasone-induced caspase-3/9 cleavage defined a caspase-dependent anti-apoptotic mechanism conferring glucocorticoid resistance.

    Evidence siRNA knockdown with flow cytometry apoptosis and cleaved caspase Western blot

    PMID:33231128

    Open questions at the time
    • Single cell context and study
    • Upstream link to caspase suppression not mechanistically resolved
  13. 2021 Low

    Expression-timing and pharmacological perturbation placed Anxa5 downstream of the GnRH/Nr4a3 axis in gonadotropin regulation.

    Evidence RT-PCR time-course over rat estrous cycle with GnRH antagonist

    PMID:33840679

    Open questions at the time
    • Correlative mRNA timing without direct functional epistasis for ANXA5
    • Single lab
  14. 2023 Medium

    Co-immunoprecipitation identified FUS as a direct ANXA5-binding partner that stabilizes ANXA5 downstream of the MIR4697HG/FUS axis to protect endothelial cells from ox-LDL injury.

    Evidence RNA pull-down, reciprocal co-IP, siRNA rescue, and ApoE-/- mouse atherosclerosis model

    PMID:38082058

    Open questions at the time
    • Mechanism by which FUS stabilizes ANXA5 not defined
    • Single lab
  15. 2025 Medium

    Membrane-injury assays in patient-derived cells linked mechanical-stress-induced ANXA5 upregulation to membrane resealing and showed this adaptive response is dysregulated in DMD muscle.

    Evidence Shear-stress and laser-injury repair assays, live-cell imaging, and DMD biopsy immunohistochemistry (preprint)

    PMID:bio_10.1101_2025.09.23.677988

    Open questions at the time
    • Preprint, not yet peer-reviewed
    • Causal contribution of ANXA5 vs ANXA6 to resealing not separated

Open questions

Synthesis pass · forward-looking unresolved questions
  • How ANXA5's membrane phosphatidylserine binding and 2D-array assembly are mechanistically coupled to its intracellular signaling outputs (ERK/Nrf2, anti-apoptotic, c-Jun/E-cadherin) remains unresolved.
  • No structural model connecting array formation to downstream signaling
  • Whether signaling roles require surface PS binding is untested
  • No unified in vivo model integrating anticoagulant and cytoprotective functions

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0008289 lipid binding 4 GO:0098772 molecular function regulator activity 2
Localization
GO:0005886 plasma membrane 4
Pathway
R-HSA-109582 Hemostasis 2 R-HSA-8953897 Cellular responses to stimuli 2 R-HSA-5357801 Programmed Cell Death 1
Partners
FUSTNAP

Evidence

Reading pass · 18 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1989 The ANXA5 (endonexin II/ENX2) gene was mapped to human chromosome 4q28-q32 by Southern transfer analysis of human x rodent somatic cell hybrid DNAs and in situ chromosome hybridization, identifying it as a member of the Ca2+-dependent phospholipid-binding annexin gene family. Somatic cell hybrid panel Southern blot analysis and in situ chromosome hybridization Cytogenetics and cell genetics Medium 2534288
1990 ANXA5 (placental anticoagulant protein-I/PAP-I) protein was localized to the microvilli of placental syncytiotrophoblast cells and their cortical cytoplasm beneath the villi, consistent with its anticoagulant function at the maternal-fetal interface. Immunocytochemistry (light and electron microscopy) Rinsho byori. The Japanese journal of clinical pathology Medium 2148197
1995 ANXA5 (CPB-I/calphobindin I) acts as an endogenous inhibitor of protein kinase C; its transcription is markedly suppressed in cervical and endometrial carcinoma cells compared to normal counterparts, as shown by immunohistochemistry, Northern blot, and in situ hybridization. Immunohistochemistry, Northern blot, in situ hybridization Gynecologic oncology Medium 7672695
2007 The M2 haplotype (four consecutive nucleotide substitutions) in the ANXA5 promoter reduces in vitro ANXA5 promoter activity to 37–42% of normal levels, as demonstrated by reporter gene assays, establishing a mechanistic link between this promoter variant and reduced ANXA5 expression associated with recurrent pregnancy loss. Reporter gene (luciferase/CAT) assay with M2 vs. wild-type promoter constructs Human molecular genetics High 17339269
2007 Anxa5-expressing (Anxa5-LacZ+) perivascular cells isolated from mouse meningeal vasculature express pericyte markers (NG2, desmin, αSMA, PDGFR-β) and Sca-1, stimulate angiogenesis when co-cultured with endothelial cells (increased PECAM expression), and promote vascularization when grafted onto quail chorioallantoic membranes, demonstrating ANXA5 as a marker of pericyte identity with a functional role in angiogenic support. Cell isolation using Anxa5-LacZ reporter, co-culture with endothelial cells, in vivo CAM graft assay, immunophenotyping Experimental cell research Medium 17543301
2010 The M2 allele of ANXA5 in heterozygous placentas results in an average 42% reduction in ANXA5 mRNA levels compared to the normal allele, directly demonstrating allele-specific reduction of ANXA5 expression in the functionally relevant organ. Allele-specific mRNA quantification in heterozygous placental tissue Placenta Medium 20805002
2014 Exogenous AnxA5 reduces plaque macrophage content in advanced atherosclerotic lesions of apoE-/- mice (59–73% reduction) and inhibits monocyte capture, rolling, adhesion, and transmigration on TNF-α-activated endothelial cells in vitro, demonstrating an anti-inflammatory mechanism through interference with monocyte recruitment via binding to phosphatidylserine on the cell surface. In vivo AnxA5 injection in apoE-/- mice with immunohistochemistry; in vitro flow chamber monocyte adhesion assay Journal of cellular and molecular medicine Medium 25214012
2016 Pharmacological concentrations of AnxA5 (1 µM) inhibit wound hemostasis and delay coagulation pathway activation in vitro; this effect requires AnxA5's ability to form 2D arrays on the cell surface, as an AnxA5 mutant that binds phosphatidylserine but cannot form 2D arrays failed to induce bleeding. Endogenous AnxA5 (at physiological levels) is dispensable for wound healing and hemostasis in AnxA5-deficient mice. AnxA5-deficient mouse wound model, recombinant wild-type and mutant AnxA5 injection, in vitro coagulation assay Cells, tissues, organs High 27178140
2016 Anxa5 knockdown in murine hepatocarcinoma Hca-F cells reduces proliferation, migration, invasion, and lymph node adhesion; mechanistically, Anxa5 mediates these effects specifically via the ERK2/p-ERK2/c-Jun/p-c-Jun(Ser73) pathway and through regulation of E-cadherin levels, not through p38MAPK/c-Jun, Jnk/c-Jun, or AKT/c-Jun pathways. shRNA knockdown, CCK-8, Boyden transwell, in situ adhesion assay, Western blot, qRT-PCR for pathway components Biomedicine & pharmacotherapy Medium 27697636
2018 Physiological micromolar Zn2+ stimulates ANXA5 transcription, raising ANXA5 protein expression and surface abundance on BeWo and HUVEC cells, resulting in prolonged coagulation times; Zn2+-fed AnxA5-deficient pregnant mice showed a trend toward increased litter size, demonstrating that zinc can upregulate ANXA5 expression to restore anticoagulant function. Cell culture transcription assay, flow cytometry for surface ANXA5, coagulation time assay, AnxA5-deficient mouse pregnancy model Reproductive sciences Medium 29716435
2019 ANXA5 overexpression in mouse Leydig and Sertoli cells activates the Nrf2/HO-1/NQO1 antioxidant pathway and attenuates DBP-induced oxidative stress; this protective effect operates through increased ERK phosphorylation, as ERK inhibition reverses the ANXA5-mediated Nrf2 pathway activation. Overexpression in cell culture, DHE staining for ROS, ELISA for MDA/SOD, Western blot for pathway proteins, ERK inhibitor rescue experiment Environmental toxicology and pharmacology Medium 31404886
2019 AnxA5 domain specifically recognizes and binds to phosphatidylserine on hypoxia-injured cells; a SDF-1-AnxA5 fusion protein accumulates at infarcted myocardium after peripheral vein injection, attenuates apoptosis, enhances angiogenesis, and improves cardiac function after mouse myocardial infarction, demonstrating ANXA5's PS-targeting function as a delivery anchor for therapeutic cargo. Receptor competition assay, binding membrane assay, immunofluorescence, mouse myocardial infarction model with fusion protein treatment Journal of cellular and molecular medicine Medium 31468674
2020 miR-506-3p directly binds to ANXA5 mRNA and reduces ANXA5 expression; overexpression of miR-506-3p aggravates DBP-induced testicular oxidative stress in rats by inhibiting the ANXA5/Nrf2/HO-1 signaling pathway, and exogenous recombinant ANXA5 reverses these effects. miRNA overexpression (agomir), recombinant ANXA5 rescue, Western blot, immunohistochemistry, oxidative stress assays in vivo and in vitro Oxidative medicine and cellular longevity Medium 33354277
2020 ANXA5 overexpression promotes glucocorticoid (dexamethasone) resistance in B-ALL cells; siRNA-mediated ANXA5 silencing combined with dexamethasone dramatically increases apoptosis and caspase-3/9 cleavage compared to either treatment alone, indicating ANXA5 suppresses caspase-dependent apoptosis to confer glucocorticoid resistance. siRNA knockdown, flow cytometry apoptosis assay, Western blot for cleaved caspase-3 and -9 Pediatric hematology and oncology Medium 33231128
2021 In rat pituitary gonadotropes, Anxa5 mRNA is induced by GnRH and rises sequentially after Nr4a3 mRNA peaks at proestrus; the functional relationship between NR4A3 and ANXA5 was established in regulating FSH-beta (Fshb) expression, with GnRH antagonist abolishing Nr4a3 induction, placing ANXA5 downstream of the GnRH/Nr4a3 axis in gonadotropin regulation. RT-PCR time-course during rat estrous cycle, GnRH antagonist treatment The Journal of reproduction and development Low 33840679
2017 ANXA5 and TNAP (tissue-nonspecific alkaline phosphatase) are co-incorporated into proteoliposomes mimicking matrix vesicles; AFM imaging revealed that ANXA5 insertion causes minimal surface protrusions (unlike TNAP), and proteoliposomes harboring both proteins show lower affinity for type II collagen fibers than those with AnxA5 alone, demonstrating that AnxA5 modulates membrane structure and collagen-binding properties relevant to biomineralization. Atomic force microscopy of proteoliposomes, collagen binding assay Biochimica et biophysica acta. Biomembranes Medium 28549727
2023 FUS (fused in sarcoma) protein directly binds ANXA5 as demonstrated by co-immunoprecipitation; lncRNA MIR4697HG stabilizes FUS, which in turn sustains ANXA5 expression to protect endothelial cells from ox-LDL-induced apoptosis and oxidative stress, placing ANXA5 downstream of the MIR4697HG/FUS axis in atherosclerosis. RNA pull-down assay (MIR4697HG–FUS), co-immunoprecipitation (FUS–ANXA5), siRNA knockdown rescue experiments, in vivo ApoE-/- mouse atherosclerosis model Biochemical genetics Medium 38082058
2025 In healthy skeletal muscle cells, mechanical stress induces upregulation of ANXA5 (and ANXA6), suggesting an adaptive membrane repair response; in DMD patient-derived skeletal muscle cells, this adaptive ANXA5 upregulation is dysregulated, associated with defective membrane resealing capacity demonstrated by shear stress and laser irradiation injury assays. Shear stress membrane injury assay, laser irradiation assay, Western blot, live-cell imaging of GFP-tagged annexins, immunohistochemistry of DMD patient biopsies bioRxivpreprint Medium bio_10.1101_2025.09.23.677988

Source papers

Stage 0 corpus · 66 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1978 The amino-acid sequence of S-100 protein (PAP I-b protein) and its relation to the calcium-binding proteins. European journal of biochemistry 351 710399
1998 Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes. Molecular and cellular biology 112 9584197
1995 Pancreatitis-associated protein I (PAP I), an acute phase protein induced by cytokines. Identification of two functional interleukin-6 response elements in the rat PAP I promoter region. The Journal of biological chemistry 100 7545677
2007 A common haplotype of the annexin A5 (ANXA5) gene promoter is associated with recurrent pregnancy loss. Human molecular genetics 94 17339269
2002 Coordinate regulation of secretory stress proteins (PSP/reg, PAP I, PAP II, and PAP III) in the rat exocrine pancreas during experimental acute pancreatitis. The Journal of surgical research 92 12121700
1995 Differential binding of Lrp to two sets of pap DNA binding sites mediated by Pap I regulates Pap phase variation in Escherichia coli. The EMBO journal 83 8846772
1999 Pokeweed antiviral protein isoforms PAP-I, PAP-II, and PAP-III depurinate RNA of human immunodeficiency virus (HIV)-1. Biochemical and biophysical research communications 67 10403789
2009 Haplotype M2 in the annexin A5 (ANXA5) gene and the occurrence of obstetric complications. Thrombosis and haemostasis 56 19652881
2001 Cdx1 promotes cellular growth of epithelial intestinal cells through induction of the secretory protein PAP I. European journal of cell biology 45 11302520
2010 Reduced allele specific annexin A5 mRNA levels in placentas carrying the M2/ANXA5 allele. Placenta 41 20805002
2007 Isolated Anxa5+/Sca-1+ perivascular cells from mouse meningeal vasculature retain their perivascular phenotype in vitro and in vivo. Experimental cell research 40 17543301
2019 The role of ANXA5 in DBP-induced oxidative stress through ERK/Nrf2 pathway. Environmental toxicology and pharmacology 31 31404886
2017 Topographic analysis by atomic force microscopy of proteoliposomes matrix vesicle mimetics harboring TNAP and AnxA5. Biochimica et biophysica acta. Biomembranes 31 28549727
2014 AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE(-/-) mice. Journal of cellular and molecular medicine 31 25214012
2019 The bifunctional SDF-1-AnxA5 fusion protein protects cardiac function after myocardial infarction. Journal of cellular and molecular medicine 26 31468674
1995 Suppression of calphobindin I (CPB I) production in carcinoma of uterine cervix and endometrium. Gynecologic oncology 26 7672695
2019 Nerve Injury-Induced Neuronal PAP-I Maintains Neuropathic Pain by Activating Spinal Microglia. The Journal of neuroscience : the official journal of the Society for Neuroscience 25 31744864
2013 Contribution of fetal ANXA5 gene promoter polymorphisms to the onset of pre-eclampsia. Placenta 24 24140079
2013 Genotyping analyses for polymorphisms of ANXA5 gene in patients with recurrent pregnancy loss. Fertility and sterility 21 23850300
2016 Anxa5 mediates the in vitro malignant behaviours of murine hepatocarcinoma Hca-F cells with high lymph node metastasis potential preferentially via ERK2/p-ERK2/c-Jun/p-c-Jun(Ser73) and E-cadherin. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 19 27697636
2012 The M2 haplotype in the ANXA5 gene is an independent risk factor for idiopathic small-for-gestational age newborns. Molecular human reproduction 16 22679123
2020 Overexpression of miR-506-3p Aggravates DBP-Induced Testicular Oxidative Stress in Rats by Downregulating ANXA5 via Nrf2/HO-1 Signaling Pathway. Oxidative medicine and cellular longevity 15 33354277
2012 Combining [11C]-AnxA5 PET imaging with serum biomarkers for improved detection in live mice of modest cell death in human solid tumor xenografts. PloS one 14 22870292
2001 Pancreatitis associated protein I (PAP-I) alters adhesion and motility of human melanocytes and melanoma cells. The Journal of investigative dermatology 14 11231317
1996 Mechanism of PAP I gene induction during hepatocarcinogenesis: clinical implications. British journal of cancer 14 8956791
2016 Lessons From the EThIGII Trial: Proper Putative Benefit Assessment of Low-Molecular-Weight Heparin Treatment in M2/ANXA5 Haplotype Carriers. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 13 27418639
2015 M2/ANXA5 haplotype as a predisposition factor in Malay women and couples experiencing recurrent spontaneous abortion: a pilot study. Reproductive biomedicine online 13 25682309
2014 Involvement of ANXA5 and ILKAP in susceptibility to malignant melanoma. PloS one 13 24743186
2013 Independent association of the M2/ANXA5 haplotype with recurrent pregnancy loss (RPL) in PCOS patients. Metabolism: clinical and experimental 13 23498654
2016 Skin Wound Repair Is Not Altered in the Absence of Endogenous AnxA1 or AnxA5, but Pharmacological Concentrations of AnxA4 and AnxA5 Inhibit Wound Hemostasis. Cells, tissues, organs 12 27178140
2003 The Polycomb-group protein ENX-2 interacts with ZAP-70. Immunology letters 12 12600746
1999 PAP I interacts with itself, PAP II, PAP III, and lithostathine/regIalpha. Molecular cell biology research communications : MCBRC 12 10662590
2022 Research progress on ANXA5 in recurrent pregnancy loss. Journal of reproductive immunology 11 35964539
2015 ANXA5 level is linked to in vitro and in vivo tumor malignancy and lymphatic metastasis of murine hepatocarcinoma cell. Future oncology (London, England) 11 26615672
1989 The human endonexin II (ENX2) gene is located at 4q28----q32. Cytogenetics and cell genetics 11 2534288
2012 The annexin A5 protective shield model revisited: inherited carriage of the M2/ANXA5 haplotype in placenta as a predisposing factor for the development of obstetric antiphospholipid antibodies. Lupus 10 22635237
2018 Maternal carriers of the ANXA5 M2 haplotype are exposed to a greater risk for placenta-mediated pregnancy complications. Journal of assisted reproduction and genetics 9 29497952
2021 Development of Tg(UAS:SEC-Hsa.ANXA5-YFP,myl7:RFP); Casper(roy-/-,nacre-/-) Transparent Transgenic In Vivo Zebrafish Model to Study the Cardiomyocyte Function. Cells 8 34440732
2005 The value of biliary amylase and Hepatocarcinoma-Intestine-Pancreas/Pancreatitis-associated Protein I (HIP/PAP-I) in diagnosing biliary malignancies. Clinical biochemistry 8 15885230
2025 ANXA5: related mechanisms of osteogenesis and additional biological functions. Frontiers in cell and developmental biology 7 40342928
2024 ANXA5: A Key Regulator of Immune Cell Infiltration in Hepatocellular Carcinoma. Medical science monitor : international medical journal of experimental and clinical research 7 38824386
2021 Sequential preovulatory expression of a gonadotropin-releasing hormone-inducible gene, Nr4a3, and its suppressor Anxa5 in the pituitary gland of female rats. The Journal of reproduction and development 7 33840679
2021 Genetic analysis of ANXA5 haplotype and its effect on recurrent pregnancy loss. Molecular medicine reports 7 34878150
2013 The haplotype M2 of the ANXA5 gene is not associated with antitrophoblast antibodies. Journal of assisted reproduction and genetics 7 23529182
1995 Identification of a transcriptional regulatory region of the rat pancreatitis-associated protein I (PAP I) gene that confers tissue specificity. The Biochemical journal 7 7487908
2023 LncRNA MIR4697HG Alleviates Endothelial Cell Injury and Atherosclerosis Progression in Mice via the FUS/ANXA5 Axis. Biochemical genetics 6 38082058
2020 Glucocorticoid resistance induced by ANXA5 overexpression in B-cell acute lymphoblastic leukemia. Pediatric hematology and oncology 5 33231128
2018 Micromolar Zinc in Annexin A5 Anticoagulation as a Potential Remedy for RPRGL3-Associated Recurrent Pregnancy Loss. Reproductive sciences (Thousand Oaks, Calif.) 5 29716435
2018 Correlation of single nucleotide polymorphisms in the promoter region of the ANXA5 (annexin A5) gene with recurrent miscarriages in women of Greek origin. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 5 30196743
2014 Disruption of murine Tcte3-3 induces tissue specific apoptosis via co-expression of Anxa5 and Pebp1. Computational biology and chemistry 5 25462330
2011 Continuous stress-induced dopamine dysregulation augments PAP-I and PAP-II expression in melanotrophs of the pituitary gland. Biochemical and biophysical research communications 5 21329657
1997 Characterization of a silencer regulatory element in the rat PAP I gene which confers tissue-specific expression and is promoter-dependent. Archives of biochemistry and biophysics 5 9126283
2017 The association between annexin A5 (ANXA5) gene polymorphism and left ventricular hypertrophy (LVH) in Chinese endogenous hypertension patients. Medicine 4 29095261
2024 SSL5-AnxA5 Fusion Protein Constructed Based on Human Atherosclerotic Plaque scRNA-Seq Data Preventing the Binding of Apoptotic Endothelial Cells, Platelets, and Inflammatory Cells. Biomedicines 3 39857592
2022 Association between ANXA5 haplotypes and the risk of recurrent pregnancy loss. The Journal of international medical research 3 35899914
2019 The relevance of ANXA5 genetic variants on male fertility. Journal of assisted reproduction and genetics 2 31190166
1990 [Morphological detection of placental anticoagulant protein-I (PAP-I) in human placenta]. Rinsho byori. The Japanese journal of clinical pathology 2 2148197
2025 Integrative analysis of single-cell and bulk RNA sequencing reveals the oncogenic role of ANXA5 in gastric cancer and its association with drug resistance. Frontiers in immunology 1 40124374
2025 Identification of functional SNP associated with sperm quality in porcine ANXA5 that contributes to the growth of immature Sertoli cell. Frontiers in veterinary science 1 40438404
2018 Antiphospholipid Antibodies in a General Obstetric Population: Clinical Impact on Pregnancy Outcome and Relationship with the M2 Haplotype in the Annexin A5 (ANXA5) Gene. Hamostaseologie 1 30304747
1999 Mouse monoclonal antibodies against Phytolacca americana antiviral protein PAP I. Hybridoma 1 10571267
2026 Conformation of CD40LG and ANXA5 as Key Events of 2,7-Dibromocarbazole-Induced Cardiotoxicity Using in Vivo and in Vitro Models. Environmental science & technology 0 41610337
2026 COL10A1 transcriptional regulation of ANXA5-mediated ferroptosis is involved in malignant progression of head and neck squamous cell carcinoma. Translational cancer research 0 41815119
2025 Single nucleotide variations in the ANXA5 promoter regulated piglet weight in the Min pig. Frontiers in veterinary science 0 41190166
2025 Remdesivir alleviates inflammation and tissue damage in experimental colitis via AnxA5 Signaling. International immunopharmacology 0 41411728
2024 ANXA5 and VEGFA Gene Variants in Women with Early Pregnancy Losses from North Macedonia. Balkan journal of medical genetics : BJMG 0 39263641

Missed literature

Know a paper Affinage missed for ANXA5? Flag it for the maintainers and the community.

No submissions yet.