Affinage

ETFB

Electron transfer flavoprotein subunit beta · UniProt P38117

Length
255 aa
Mass
27.8 kDa
Annotated
2026-06-09
95 papers in source corpus 14 papers cited in narrative 14 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ETFB encodes the beta subunit of the mitochondrial electron transfer flavoprotein (ETF), which together with ETFA forms a heterodimeric electron-transfer hub that accepts electrons from at least 14 matrix flavoenzymes, including acyl-CoA dehydrogenases, by direct flavin-to-flavin transfer and relays them to ETF:QO (ETFDH) and onward to ubiquinone at the respiratory chain (PMID:33450351). ETFB physically interacts with glutaryl-CoA dehydrogenase (GCDH), for which it serves as electron acceptor (PMID:24498361), and is found in complex with mitochondrial connexin 43 and AIF in cardiac subsarcolemmal mitochondria (PMID:26915330). The ETF heterodimer is post-translationally stabilized: neddylation (NEDD8 conjugation) of ETFB and ETFA suppresses their ubiquitination and degradation, with loss of this modification producing a glutaric aciduria type II–like phenotype (PMID:31941714), and a trimeric interaction with S1P/MBTPS1 promotes ETF flavination and stability (PMID:35362222). Loss-of-function ETFB mutations cause multiple acyl-CoA dehydrogenation deficiency (MADD/glutaric aciduria type II), impairing fibroblast fatty acid oxidation and yielding abnormal acylcarnitine profiles, with residual ETF activity correlating with disease severity (PMID:12706375, PMID:16510302). ETFB is required for the survival of AML cells but not normal CD34+ cells (PMID:35177813), and is detected as an endothelial autoantigen in Behçet's disease (PMID:25915519); beyond its canonical bioenergetic role, ETFB also participates in mechanoregulation of fibroblast cell number and TGF-β-induced alpha-SMA expression under mechanical stress (PMID:21903359, PMID:23068445).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 1992 Medium

    Established that mammalian ETF exists in interconvertible redox/cofactor forms while retaining catalytic competence as an electron shuttle between acyl-CoA dehydrogenase and an artificial acceptor, defining its core biochemical activity.

    Evidence Biochemical purification and spectrophotometric reduction/reconstitution assays of pig kidney ETF

    PMID:1731621

    Open questions at the time
    • Does not resolve which subunit carries the FAD analogue
    • Performed on a non-human ortholog
    • Physiological relevance of the ETFB-vs-ETFR distinction unclear
  2. 1994 Low

    Localized the human ETFB gene to chromosome 19q13.4, providing the genomic anchor for subsequent mutation analysis.

    Evidence Cosmid cloning and chromosomal mapping by somatic cell genetics and FISH

    PMID:8197479

    Open questions at the time
    • Mapping only, no functional data
    • No gene structure or regulatory information
  3. 2003 Medium

    Demonstrated that specific ETFB missense and deletion mutations cause MADD/glutaric aciduria type II by impairing fatty acid oxidation, directly linking the beta subunit to disease.

    Evidence Mutational analysis plus fibroblast [3H]-palmitate/myristate oxidation assays and bacterial expression with activity rescue

    PMID:12706375 PMID:12815589

    Open questions at the time
    • Limited number of patients/mutations
    • Mechanism by which mutations destabilize the heterodimer not resolved
    • Temperature-sensitive rescue shown only in E. coli
  4. 2006 Medium

    Confirmed the alpha/beta heterodimeric architecture of human ETF and quantified that residual ETF activity correlates with MADD severity, establishing genotype-to-phenotype gradation.

    Evidence ETF activity assays, Western blot, and mutation analysis in patient tissues

    PMID:16510302

    Open questions at the time
    • ETFB mutations rare relative to ETFA in this cohort
    • Does not address structural basis of activity loss
  5. 2012 Medium

    Revealed a non-canonical role for ETFB in fibroblast mechanobiology, showing it is required for stress-dependent cell number control and TGF-β-induced myofibroblast marker expression.

    Evidence siRNA knockdown with collagen gel culture, qRT-PCR, proliferation and stress-fiber assays in human fibroblasts

    PMID:21903359 PMID:23068445

    Open questions at the time
    • Molecular link between mitochondrial ETF function and mechanosignaling unknown
    • Single lab, no in vivo confirmation
    • Whether effect is metabolic or moonlighting unresolved
  6. 2014 Medium

    Identified a direct physical interaction with GCDH, establishing ETFB as the electron-accepting partner for a specific matrix dehydrogenase.

    Evidence Affinity chromatography pulldown, mass spectrometry, and YFP bimolecular fluorescence complementation in living cells

    PMID:24498361

    Open questions at the time
    • Stoichiometry and structural interface not defined
    • Generalizability to other dehydrogenase partners not tested
  7. 2015 Medium

    Identified ETFB as an endothelial autoantigen recognized by Behçet's disease patient sera, implicating it in autoimmune reactivity.

    Evidence Western blotting and mass spectrometry from endothelial extracts probed with patient sera, plus ELISA in a patient cohort

    PMID:25915519

    Open questions at the time
    • Pathogenic role of anti-ETFB antibodies unknown
    • Mechanism of surface/extracellular exposure of a mitochondrial protein unexplained
  8. 2016 Medium

    Placed ETFB in a cardiac mitochondrial protein complex with connexin 43 and AIF, expanding its interactome beyond electron-transfer substrates.

    Evidence Native and reciprocal co-immunoprecipitation with mass spectrometry from mouse heart subsarcolemmal mitochondria

    PMID:26915330

    Open questions at the time
    • Functional consequence of Cx43/AIF association undefined
    • Direct vs indirect binding not distinguished
  9. 2020 High

    Defined neddylation as a post-translational mechanism that stabilizes ETFB/ETFA by blocking their ubiquitin-mediated degradation, with loss causing a GA-II-like phenotype in vivo.

    Evidence Liver-specific UBA3/NEDD8 knockout mice, direct neddylation and ubiquitination assays, and disease-mutation validation

    PMID:31941714

    Open questions at the time
    • Site(s) of NEDD8 conjugation on ETFB not mapped
    • Upstream signals controlling ETF neddylation unknown
  10. 2022 High

    Showed that S1P/MBTPS1 forms a trimeric complex with ETFA/ETFB to promote flavination and stability, and that ETFB is selectively required for AML cell mitochondrial function and survival.

    Evidence Co-IP, flavination and respiration/β-oxidation assays with riboflavin rescue in patient cells; siRNA/shRNA silencing with mitochondrial and apoptosis assays in AML vs CD34+ cells

    PMID:35177813 PMID:35362222

    Open questions at the time
    • Mechanism by which S1P facilitates FAD loading not structurally resolved
    • Basis of AML-selective dependence on ETFB unclear

Open questions

Synthesis pass · forward-looking unresolved questions
  • How ETFB's canonical electron-transfer role mechanistically connects to its reported moonlighting functions in mechanotransduction, autoimmunity, and AML dependence remains unresolved.
  • No structural model of the S1P-ETF trimeric complex
  • Neddylation site on ETFB unmapped
  • Link between mitochondrial ETF activity and TGF-β/mechanosignaling unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016491 oxidoreductase activity 3 GO:0008289 lipid binding 1 GO:0140104 molecular carrier activity 1
Localization
GO:0005739 mitochondrion 5
Pathway
R-HSA-1643685 Disease 4 R-HSA-1430728 Metabolism 2
Partners
AIFM1ETFAETFDHGCDHGJA1MBTPS1NEDD8UBA3
Complex memberships
S1P-ETFA-ETFB trimeric complexelectron transfer flavoprotein (ETFA/ETFB) heterodimer

Evidence

Reading pass · 14 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1992 Mammalian ETF from pig kidney exists in two forms (ETFR and ETFB) distinguishable by their flavin semiquinone upon reduction: the normal form (ETFR) generates a red anionic semiquinone, while ETFB generates a blue neutral semiquinone. ETFB contains a substoichiometric unusual FAD analogue. Both forms have comparable catalytic activity mediating electron transfer between medium-chain acyl-CoA dehydrogenase and 2,6-dichlorophenolindophenol. ETFB can be converted to ETFR by full reduction at pH 6.5 or apoprotein reconstitution with FAD, but not the reverse. Biochemical purification, spectrophotometric reduction assays (photochemical, dithionite, enzymatic), apoprotein reconstitution Archives of biochemistry and biophysics Medium 1731621
2003 ETFB missense mutation D128N (identified in a type III MADD patient) results in reduced enzyme activity that can be rescued up to 59% of wild-type when expressed in E. coli at low temperature, demonstrating that environmental temperature can modulate the ETF enzymatic phenotype caused by this missense mutation. Overexpression of mutant ETFB-D128N in E. coli at low temperature followed by activity measurement; genomic structure determination and mutation characterization Human mutation Medium 12815589
2003 ETFB missense mutations C42R and K202del (deletion of lysine-202) cause a late-onset mild form of MADD/GAII, establishing that beta-ETF deficiency specifically due to ETFB mutations leads to impaired palmitate/myristate oxidation in fibroblasts and abnormal acylcarnitine profiles. Mutational analysis of ETFB gene; fibroblast fatty acid oxidation assays ([3H]-palmitate and [3H]-myristate oxidation) Molecular genetics and metabolism Medium 12706375
2006 Human ETF is a heterodimer of alpha (ETFA, 30 kDa) and beta (ETFB, 28 kDa) subunits encoded by separate nuclear genes; ETF activity in patient tissue samples ranges from <1 to 16% of controls and directly correlates with disease severity in MADD patients with confirmed ETF deficiency; most mutations causing ETF deficiency are in ETFA, with only two patients harboring ETFB mutations. ETF activity assay in patient tissue samples, Western blot analysis, mutation analysis Molecular genetics and metabolism Medium 16510302
2011 ETFB siRNA knockdown in human fibroblasts reduces cell number specifically in mechanically stressed (attached) collagen gel culture without affecting cell number in detached (stress-free) culture, identifying ETFB as a participant in mechanoregulation of fibroblast cell number. 2D gel electrophoresis differential display, MALDI-TOF-MS protein identification, siRNA knockdown, collagen gel culture assay with cell counting Journal of dermatological science Medium 21903359
2012 ETFB knockdown in fibroblasts attenuates TGF-β-induced alpha-SMA mRNA expression under mechanical stress conditions (attached collagen gel culture) to levels comparable to those without TGF-β, and weakens stress fiber organization induced by TGF-β, but does not affect COL1A1 mRNA levels or cell proliferation on plastic. siRNA knockdown, qRT-PCR, AlamarBlue proliferation assay, phalloidin staining of stress fibers, collagen gel contraction assay Journal of dermatological science Medium 23068445
2014 ETFB (beta-subunit of electron transfer flavoprotein) physically interacts with glutaryl-CoA dehydrogenase (GCDH) in mitochondria, identified by affinity chromatography and visualized by YFP-based fragment complementation in living cells; ETFB serves as an electron acceptor for GCDH. Affinity chromatography pulldown of GCDH-interacting proteins, mass spectrometry identification, YFP bimolecular fluorescence complementation in living cells PloS one Medium 24498361
2016 Connexin 43 (Cx43) interacts with ETFB in the subsarcolemmal mitochondrial fraction of mouse heart, as demonstrated by direct and reverse co-immunoprecipitation; additionally, a novel interaction between AIF and ETFB was identified, with AIF and ETFB protein content and subcellular localization being independent of Cx43 presence. Native immunoprecipitation from mitochondrial extracts, mass spectrometry identification, direct and reverse co-immunoprecipitation, subcellular fractionation Journal of cellular and molecular medicine Medium 26915330
2020 Neddylation (NEDD8 conjugation) directly targets ETFB (and ETFA) as substrates in hepatic mitochondria, stabilizing ETF proteins by inhibiting their ubiquitination and degradation. Liver-specific UBA3 (NEDD8-activating enzyme catalytic subunit) deficiency leads to decreased ETFB and ETFA protein levels, spontaneous fatty liver, and a glutaric aciduria type II-like phenotype. Certain GA-II patient mutations in ETFB hinder its neddylation. Liver-specific UBA3 and NEDD8 knockout mouse models, neddylation assays with ETF substrates, ubiquitination assays, Western blot analysis in neonatal livers and embryonic hepatocytes, pharmacological neddylation inhibition Proceedings of the National Academy of Sciences of the United States of America High 31941714
2021 Human ETF heterodimer (ETFA+ETFB) functions as an electron transfer hub accepting electrons from at least 14 flavoenzymes (including acyl-CoA dehydrogenases) in the mitochondrial matrix and relaying them to ETF:QO (ETFDH) via iron-sulfur cluster, then to ubiquinone entering the respiratory chain at complex III level. Electron transfer from donor enzymes to ETF occurs by direct flavin-to-flavin transfer regulated by a recognition loop and dynamic movement of the ETF flavin domain. Review synthesizing structural, biochemical, and mutational studies; cofactor analysis (FAD and AMP in heterodimer) Gene Medium 33450351
2022 S1P (site-1 protease/MBTPS1) is a novel mitochondrial protein that forms a trimeric complex with ETFA/ETFB. S1P enhances ETFA/ETFB flavination and maintains their stability. Patient S1P variants destabilize ETFA/ETFB, impair mitochondrial respiration and fatty acid β-oxidation, and shift OXPHOS to glycolysis. Riboflavin supplementation restored ETFA/ETFB stability and ameliorated mitochondrial dysfunction in the patient. Co-immunoprecipitation to identify S1P-ETFA/ETFB trimeric complex; functional assays for flavination, mitochondrial respiration, β-oxidation activity; patient cell studies; riboflavin rescue experiment EMBO molecular medicine High 35362222
2022 Silencing of ETFB (and ETFA) in AML cells leads to increased mitochondrial activity, mitochondrial stress, and apoptosis, but has little to no effect on normal human CD34+ cells, indicating ETFB is required for AML cell survival and mitochondrial function. siRNA/shRNA silencing, mitochondrial activity assays, apoptosis assays in AML cell lines vs. normal CD34+ cells; quantitative mass spectrometry and RNAseq showing ETFB upregulated at protein but not transcript level in AML Leukemia Medium 35177813
2015 Electron transfer flavoprotein subunit beta (ETFB) was identified as a candidate endothelial cell autoantigen in Behçet's disease: ETFB was detected by Western blotting and mass spectrometry from endothelial cell extracts probed with BD patient sera, recombinant ETFB was cloned and expressed, and ELISA showed positive reactivity in 41% of BD patients versus 1% of healthy controls. Western blotting with patient sera, LC-MALDI-TOF/TOF mass spectrometry identification, recombinant protein expression/purification, ELISA with patient cohort PloS one Medium 25915519
1994 The human ETFB gene maps to chromosome 19q13.4, within approximately 40 kb of the LIM2 gene, as demonstrated by identifying a cosmid containing sequences from both genes. Cosmid cloning, chromosomal mapping by somatic cell genetics and FISH Somatic cell and molecular genetics Low 8197479

Source papers

Stage 0 corpus · 95 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2007 Expression of Clostridium acetobutylicum butanol synthetic genes in Escherichia coli. Applied microbiology and biotechnology 198 18060402
2003 Clear relationship between ETF/ETFDH genotype and phenotype in patients with multiple acyl-CoA dehydrogenation deficiency. Human mutation 191 12815589
2007 Comprehensive analysis of PPARalpha-dependent regulation of hepatic lipid metabolism by expression profiling. PPAR research 184 18288265
2008 The identification of potential factors associated with the development of type 2 diabetes: a quantitative proteomics approach. Molecular & cellular proteomics : MCP 163 18448419
2020 Integrated analysis of ultra-deep proteomes in cortex, cerebrospinal fluid and serum reveals a mitochondrial signature in Alzheimer's disease. Molecular neurodegeneration 162 32711556
2014 Clinical and genetical heterogeneity of late-onset multiple acyl-coenzyme A dehydrogenase deficiency. Orphanet journal of rare diseases 150 25200064
2021 Electron transfer flavoprotein and its role in mitochondrial energy metabolism in health and disease. Gene 101 33450351
1996 Cloning, sequencing, and expression of clustered genes encoding beta-hydroxybutyryl-coenzyme A (CoA) dehydrogenase, crotonase, and butyryl-CoA dehydrogenase from Clostridium acetobutylicum ATCC 824. Journal of bacteriology 100 8655474
2010 Reconstructing the clostridial n-butanol metabolic pathway in Lactobacillus brevis. Applied microbiology and biotechnology 94 20195860
2009 Riboflavin-responsive lipid-storage myopathy caused by ETFDH gene mutations. Journal of neurology, neurosurgery, and psychiatry 92 19758981
2006 Electron transfer flavoprotein deficiency: functional and molecular aspects. Molecular genetics and metabolism 90 16510302
2006 Organization and function of the YsiA regulon of Bacillus subtilis involved in fatty acid degradation. The Journal of biological chemistry 87 17189250
2011 Molecular analysis of 51 unrelated pedigrees with late-onset multiple acyl-CoA dehydrogenation deficiency (MADD) in southern China confirmed the most common ETFDH mutation and high carrier frequency of c.250G>A. Journal of molecular medicine (Berlin, Germany) 81 21347544
2021 Riboflavin in Neurological Diseases: A Narrative Review. Clinical drug investigation 73 33886098
2006 Bacillus subtilis gene cluster involved in calcium carbonate biomineralization. Journal of bacteriology 66 17085570
2015 Energy Conservation Model Based on Genomic and Experimental Analyses of a Carbon Monoxide-Utilizing, Butyrate-Forming Acetogen, Eubacterium limosum KIST612. Applied and environmental microbiology 65 25956767
2008 Clinical and molecular investigations of Japanese cases of glutaric acidemia type 2. Molecular genetics and metabolism 64 18289905
2007 Dissection of the caffeate respiratory chain in the acetogen Acetobacterium woodii: identification of an Rnf-type NADH dehydrogenase as a potential coupling site. Journal of bacteriology 57 17873051
2012 Update on clinical aspects and treatment of selected vitamin-responsive disorders II (riboflavin and CoQ 10). Journal of inherited metabolic disease 56 22231380
2016 New protein-protein interactions of mitochondrial connexin 43 in mouse heart. Journal of cellular and molecular medicine 53 26915330
2013 Comparative study of the neurotrophic effects elicited by VEGF-B and GDNF in preclinical in vivo models of Parkinson's disease. Neuroscience 51 24291725
2011 Single-nucleotide resolution analysis of the transcriptome structure of Clostridium beijerinckii NCIMB 8052 using RNA-Seq. BMC genomics 49 21962126
2020 Hepatic neddylation targets and stabilizes electron transfer flavoproteins to facilitate fatty acid β-oxidation. Proceedings of the National Academy of Sciences of the United States of America 46 31941714
2009 Novel mutations in ETFDH gene in Chinese patients with riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency. Clinica chimica acta; international journal of clinical chemistry 44 19265687
2020 Disorders of flavin adenine dinucleotide metabolism: MADD and related deficiencies. The international journal of biochemistry & cell biology 42 33279678
2013 Multi-organ abnormalities and mTORC1 activation in zebrafish model of multiple acyl-CoA dehydrogenase deficiency. PLoS genetics 39 23785301
2018 Coenzyme Q10 serves to couple mitochondrial oxidative phosphorylation and fatty acid β-oxidation, and attenuates NLRP3 inflammasome activation. Free radical research 32 30003820
2018 A Novel Truncating FLAD1 Variant, Causing Multiple Acyl-CoA Dehydrogenase Deficiency (MADD) in an 8-Year-Old Boy. JIMD reports 32 30311138
2006 So doctor, what exactly is wrong with my muscles? Glutaric aciduria type II presenting in a teenager. Neuromuscular disorders : NMD 31 16527485
2016 Significant clinical heterogeneity with similar ETFDH genotype in three Chinese patients with late-onset multiple acyl-CoA dehydrogenase deficiency. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 29 27000805
2003 Late-onset form of beta-electron transfer flavoprotein deficiency. Molecular genetics and metabolism 29 12706375
2020 Multiple acyl-COA dehydrogenase deficiency in elderly carriers. Journal of neurology 28 31997039
2017 Exome array analysis identifies ETFB as a novel susceptibility gene for anthracycline-induced cardiotoxicity in cancer patients. Breast cancer research and treatment 28 28913729
2021 Multiple acyl-CoA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection. Nature communications 27 34782606
2022 S1P defects cause a new entity of cataract, alopecia, oral mucosal disorder, and psoriasis-like syndrome. EMBO molecular medicine 25 35362222
2022 Diagnostic Challenges in Late Onset Multiple Acyl-CoA Dehydrogenase Deficiency: Clinical, Morphological, and Genetic Aspects. Frontiers in neurology 23 35309592
2019 Determinants of Riboflavin Responsiveness in Multiple Acyl-CoA Dehydrogenase Deficiency. Pediatric neurology 21 31331668
2018 Putative Iron Acquisition Systems in Stenotrophomonas maltophilia. Molecules (Basel, Switzerland) 21 30115820
2016 Functional characterization of electron-transferring flavoprotein and its dehydrogenase required for fungal development and plant infection by the rice blast fungus. Scientific reports 21 27113712
2013 Fermentation approach for enhancing 1-butanol production using engineered butanologenic Escherichia coli. Bioresource technology 21 23453982
2010 A caffeyl-coenzyme A synthetase initiates caffeate activation prior to caffeate reduction in the acetogenic bacterium Acetobacterium woodii. Journal of bacteriology 21 21131487
2022 Multi-omics reveals mitochondrial metabolism proteins susceptible for drug discovery in AML. Leukemia 20 35177813
2022 Structure-based electron-confurcation mechanism of the Ldh-EtfAB complex. eLife 20 35748623
2019 Flavin adenine dinucleotide synthase deficiency due to FLAD1 mutation presenting as multiple acyl-CoA dehydrogenation deficiency-like disease: A case report. Brain & development 20 30982706
2011 Catabolite repression of the Bacillus subtilis FadR regulon, which is involved in fatty acid catabolism. Journal of bacteriology 20 21398533
2017 Identification of novel biomarker and therapeutic target candidates for diagnosis and treatment of follicular carcinoma. Journal of proteomics 19 28709933
2014 Interaction of glutaric aciduria type 1-related glutaryl-CoA dehydrogenase with mitochondrial matrix proteins. PloS one 19 24498361
2019 FLAD1-associated multiple acyl-CoA dehydrogenase deficiency identified by newborn screening. Molecular genetics & genomic medicine 17 31392824
2021 Melatonin Modulates Lipid Metabolism in Porcine Cumulus-Oocyte Complex via Its Receptors. Frontiers in cell and developmental biology 14 33869202
2020 A novel electron transfer flavoprotein dehydrogenase (ETFDH) gene mutation identified in a newborn with glutaric acidemia type II: a case report of a Chinese family. BMC medical genetics 13 32393189
2015 Transcriptional analysis of micronutrient zinc-associated response for enhanced carbohydrate utilization and earlier solventogenesis in Clostridium acetobutylicum. Scientific reports 13 26586044
2014 Cellular responses in Bacillus thuringiensis CS33 during bacteriophage BtCS33 infection. Journal of proteomics 13 24565692
1992 A new form of mammalian electron-transferring flavoprotein. Archives of biochemistry and biophysics 12 1731621
2024 Molecular genetic analysis of candidate genes for glutaric aciduria type II in a cohort of patients from Queensland, Australia. Molecular genetics and metabolism 11 38941880
2023 Proteomics reveals specific biological changes induced by the normothermic machine perfusion of donor kidneys with a significant up-regulation of Latexin. Scientific reports 11 37041202
2021 Hypoketotic hypoglycemia without neuromuscular complications in patients with SLC25A32 deficiency. European journal of human genetics : EJHG 11 34764427
1994 Assignment of the human lens fiber cell MP19 gene (LIM2) to chromosome 19q13.4, and adjacent to ETFB. Somatic cell and molecular genetics 11 8197479
2024 MADD-like pattern of acylcarnitines associated with sertraline use. Molecular genetics and metabolism reports 10 39318848
2019 Molecular and Clinical Investigations on Portuguese Patients with Multiple acyl-CoA Dehydrogenase Deficiency. Current molecular medicine 10 31418342
2010 Role of postmortem genetic testing demonstrated in a case of glutaric aciduria type II. Diagnostic molecular pathology : the American journal of surgical pathology, part B 10 20736750
2020 Mitochondrial energetic impairment in a patient with late-onset glutaric acidemia Type 2. American journal of medical genetics. Part A 9 32804429
2024 Identification of key genes in chronic intermittent hypoxia-induced lung cancer progression based on transcriptome sequencing. BMC cancer 8 38183079
2012 Engineering a homobutanol fermentation pathway in Escherichia coli EG03. Journal of industrial microbiology & biotechnology 8 22776992
2021 Transcriptome profiling analysis of the response to walnut polyphenol extract in Helicobacter pylori-infected cells. Journal of clinical biochemistry and nutrition 7 34025022
2015 Electron Transfer Flavoprotein Subunit Beta Is a Candidate Endothelial Cell Autoantigen in Behçet's Disease. PloS one 7 25915519
2014 A proteomics approach to identify the differential protein level in cardiac muscle of diabetic rat. Acta biochimica Polonica 7 24918489
2011 Identification of ETFB as a candidate protein that participates in the mechanoregulation of fibroblast cell number in collagen gel culture. Journal of dermatological science 7 21903359
2021 Screening of multiple acyl-CoA dehydrogenase deficiency in newborns and follow-up of patients. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 6 34704421
2012 Knockdown of electron transfer flavoprotein β subunit reduced TGF-β-induced α-SMA mRNA expression but not COL1A1 in fibroblast-populated three-dimensional collagen gel cultures. Journal of dermatological science 6 23068445
2024 Exploring Aerobic Energy Metabolism in Breast Cancer: A Mutational Profile of Glycolysis and Oxidative Phosphorylation. International journal of molecular sciences 5 39684297
2023 Electrochemical aptasensor detection of electron transfer flavoprotein subunit beta for leptospirosis diagnosis. The Analyst 5 37599631
2023 Characterization of the Membrane-Associated Electron-Bifurcating Flavoenzyme EtfABCX from the Hyperthermophilic Bacterium Thermotoga maritima. Biochemistry 5 38061393
2022 Transcriptomic Analyses of Grapevine Leafroll-Associated Virus 3 Infection in Leaves and Berries of 'Cabernet Franc'. Viruses 5 36016453
2021 Quantitative proteomics analysis reveals unique but overlapping protein signatures in HIV infections. Journal of infection and public health 5 34030014
2015 An electron transfer flavoprotein is essential for viability and its depletion causes a rod-to-sphere change in Burkholderia cenocepacia. Microbiology (Reading, England) 5 26253539
2024 Mechanism of Cr(VI) bioreduction by Clostridium sp. LQ25 under Fe(III) reducing conditions. Chemosphere 4 38171403
2022 Multiple Acyl-Coenzyme A Dehydrogenase Deficiency Leading to Severe Metabolic Acidosis in a Young Adult. AACE clinical case reports 4 36654993
2016 ATP5B and ETFB metabolic markers in children with congenital hydronephrosis. Molecular medicine reports 4 27840937
2024 Deep Intronic ETFDH Variants Represent a Recurrent Pathogenic Event in Multiple Acyl-CoA Dehydrogenase Deficiency. International journal of molecular sciences 3 39273584
2017 Evaluation of the electron transfer flavoprotein as an antibacterial target in Burkholderia cenocepacia. Canadian journal of microbiology 3 28817787
2025 Predicting microRNAs and their Target Genes Involved in Sepsis Pathogenesis by using Bioinformatics Methods. Current pharmaceutical design 2 39754769
2025 Lysine 2-hydroxyisobutyrylation of HXK1 alters energy metabolism and KATP channel function in the atrium from patients with atrial fibrillation. Cell communication and signaling : CCS 2 40033384
2025 Integrative transcriptomic and proteomic analyses of different muscles reveal the molecular mechanism of pig psoas major muscle as a high eating and nutritional quality meat. BMC genomics 2 41120854
2024 Transcriptomic Analysis of Cardiac Tissues in a Rodent Model of Coronary Microembolization. Journal of inflammation research 2 39345897
2022 A fatal case of neonatal onset multiple acyl-CoA dehydrogenase deficiency caused by novel mutation of ETFDH gene: case report. Italian journal of pediatrics 2 36064718
2022 A novel deleterious ETFA promoter variant causative of multiple acyl-CoA dehydrogenase deficiency. American journal of medical genetics. Part A 2 36579410
2015 A novel ETFB mutation in a patient with glutaric aciduria type II. Human genome variation 2 27081516
2012 Homology cloning, sequence characterization, and expression analysis of cDNA encoding electron transfer flavoprotein beta polypeptide in mud crab (Scylla paramamosain). Genetics and molecular research : GMR 2 23212402
2025 Literature-Guided 6-Gene Signature for the Stratification of High-Risk Acute Myeloid Leukemia. Cancer research and treatment 1 39901703
2025 Transcriptome Analysis Suggests Dietary Tributyrin Enhances Feeding Intensity via Modulating Steroid Biosynthesis in Mandarin Fish (Siniperca chuatsi). Genes 1 41465067
2026 STARD10 regulates human pancreatic β cell differentiation and triglyceride metabolism. Stem cell reports 0 41687621
2026 Response of an Infant With Presumed Multiple Acyl-CoA Dehydrogenase Deficiency (MADD) to Ketone Supplementation. American journal of medical genetics. Part A 0 42037170
2025 Proteomic landscape of porcine induced neural stem cell reprogramming and differentiation. PeerJ 0 41059408
2025 UQCR10 and TNNT1: novel biomarkers for sarcopenia identified through integrated transcriptomic analysis and machine learning. European journal of medical research 0 41320776
2024 A compound heterozygote case of glutaric aciduria type II in a patient carrying a novel candidate variant in ETFDH gene: A case report and literature review on compound heterozygote cases. Molecular genetics & genomic medicine 0 38967380

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