Affinage

EDC3

Enhancer of mRNA-decapping protein 3 · UniProt Q96F86

Length
508 aa
Mass
56.1 kDa
Annotated
2026-06-09
30 papers in source corpus 22 papers cited in narrative 21 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

EDC3 is a modular mRNA decapping activator and P-body scaffold that couples decay-enzyme activation to cytoplasmic ribonucleoprotein granule organization (PMID:17923697, PMID:22085934). Its three domains partition the work: an N-terminal divergent LSm domain that mediates DCP1 binding and P-body localization and that engages a noncanonical helical leucine-rich motif (HLM) in the disordered C-terminal extension of DCP2 (PMID:17923697, PMID:22085934); a central FDF motif that binds the C-terminal RecA-like domain of the DEAD-box helicase DDX6/Me31B/Dhh1 in a manner mutually exclusive with the related repressors Tral and Pat1 (PMID:17923697, PMID:19285948, PMID:23851565); and a C-terminal YjeF_N domain that dimerizes, binds NADH, and is required for RNA binding and substrate-specific decay (PMID:18678652, PMID:24504254). Through HLM engagement, EDC3 stabilizes the active conformation of the DCP1–DCP2 complex to directly stimulate decapping, as captured in crystal structures of the active ternary and Edc1-bridged complexes bound to product or substrate analogs (PMID:22085934, PMID:27694841, PMID:29559651). EDC3 directs both general and substrate-specific decay, binding the 3'-UTR regulatory element of RPS28B mRNA for autoregulatory decay and acting redundantly with Scd6 to recruit Dhh1 and target broad mRNA populations (PMID:24492965, PMID:41289350, PMID:39257769). EDC3 activity is gated by phosphorylation: AKT and Pim1/Pim3 phosphorylate Ser-161, promoting 14-3-3 binding and excluding EDC3 from P-bodies, with the Pim-EDC3-S161 axis driving prostate cancer cell growth and invasion (PMID:20051463, PMID:33586867); a stress-responsive Tyr-475 site cross-talks with S161 and modulates DDX6 and DCP1 interactions (PMID:36476517). A homozygous EDC3 p.Phe54Ser mutation that abolishes DCP2 stimulation causes intellectual disability (PMID:25701870).

Mechanistic history

Synthesis pass · year-by-year structured walk · 21 steps
  1. 2007 High

    Established EDC3 as a multidomain adaptor by assigning each domain a distinct binding partner, explaining how one protein links decapping enzymes, a helicase, and P-body targeting.

    Evidence NMR/crystal structures, mutagenesis, co-IP, and P-body localization of Drosophila and human EDC3 domains

    PMID:17923697

    Open questions at the time
    • Did not show whether DCP2 binding directly stimulates catalysis
    • Functional consequence of the divergent monomeric LSm fold unresolved
  2. 2008 High

    Distinguished EDC3 from the paralogous repressor Tral, showing both share LSm/FDF-based interactions but only EDC3 engages the decapping enzyme DCP2.

    Evidence Reciprocal co-IP, NMR structure, mutagenesis, and microscopy in Drosophila cells

    PMID:18765641

    Open questions at the time
    • Mechanistic basis of the EDC3-specific DCP2 association not structurally defined here
  3. 2008 High

    Defined the YjeF_N domain as a dimerization module linking oligomerization to RNA binding, P-body formation, and substrate-specific decay.

    Evidence Crystal structure, sedimentation analysis, structure-based mutagenesis, P-body and mRNA decay assays

    PMID:18678652

    Open questions at the time
    • Whether the Rossmann-like fold carries enzymatic activity was unaddressed
    • RNA target specificity conferred by dimerization unknown
  4. 2009 High

    Revealed the structural basis of FDF–helicase recognition and that EDC3 and Tral compete for the same DDX6 surface, defining mutually exclusive helicase complexes.

    Evidence Crystal structure of DDX6 RecA domain bound to EDC3 FDF, competition and functional assays

    PMID:19285948

    Open questions at the time
    • How exclusivity is regulated in cells not determined
    • Did not address Pat1 competition
  5. 2010 High

    Demonstrated that EDC3 binding to a peptide C-terminal to the DCP2 catalytic domain is required to stimulate decapping in vitro and is needed for some but not all substrate decay events.

    Evidence In vitro decapping reconstitution, deletion analysis, P-body microscopy, mRNA decay in yeast

    PMID:20086104

    Open questions at the time
    • Structural mechanism of activation not yet resolved
    • Why YRA1 decay is independent of this region unexplained
  6. 2010 High

    Connected EDC3 to insulin/AKT signaling, showing Ser-161 phosphorylation recruits 14-3-3 and remodels P-bodies and miRNA-mediated regulation.

    Evidence Phosphoproteomics, AKT kinase assay, S161 mutagenesis, 14-3-3 co-IP, reporter assays

    PMID:20051463

    Open questions at the time
    • Direct effect of phosphorylation on decapping activity not measured
    • Range of regulated mRNAs not defined
  7. 2011 High

    Defined the noncanonical LSm–HLM interaction mode and proposed that EDC3 activates decapping by preventing the inactive DCP1:DCP2 conformation, with Scd6 as a competitor.

    Evidence Crystal structure of Edc3 LSm–Dcp2 HLM complex, in vitro decapping, mutagenesis

    PMID:22085934

    Open questions at the time
    • Direct structural proof of the active conformation came later
    • Metazoan HLM-on-DCP1 functional consequences not tested here
  8. 2011 Medium

    Placed EDC3 at the interface with NMD machinery by mapping an Upf1 N-terminal binding site, while showing EDC3 is dispensable for general NMD.

    Evidence Yeast two-hybrid, deletion mapping, NMD reporter assays

    PMID:22065998

    Open questions at the time
    • Yeast two-hybrid without reciprocal biochemical validation
    • Functional role of the Upf1 interaction undefined
  9. 2013 High

    Showed Pat1 binds the same DDX6/Dhh1 surface as EDC3, extending the competition model and identifying RNA-competitive binding by both factors.

    Evidence Crystal structure of Dhh1–Pat1, mutant co-IP, crosslinking-MS RNA mapping, human co-IP

    PMID:23851565

    Open questions at the time
    • Cellular switching between Pat1- and Edc3-bound helicase states unresolved
  10. 2013 High

    Identified a lineage-specific Rps28-binding motif on Edc3 required for RPS28B autoregulatory decay but not general decapping, distinguishing dedicated from housekeeping functions.

    Evidence Biochemical binding, mutagenesis, mRNA decay, phylogenetics

    PMID:23956223

    Open questions at the time
    • Initially attributed substrate recognition to Rps28 binding, later revised
  11. 2014 High

    Revised the RPS28B model by showing Edc3 directly binds the mRNA 3'-UTR element, with Rps28b acting as a regulator of Edc3 rather than the RNA-binding bridge.

    Evidence RNA-binding assays, domain deletion, mRNA decay, co-IP in yeast

    PMID:24492965

    Open questions at the time
    • Sequence/structural determinants of the 3'-UTR element recognition not mapped
  12. 2014 Medium

    Showed the YjeF_N domain binds NADH and can chemically modify NAD, linking a metabolite-binding activity to decay control and P-body composition.

    Evidence Crystal structure, in vitro NADH binding and NAD modification, mutagenesis, functional assays

    PMID:24504254

    Open questions at the time
    • Physiological substrate and product of the NAD modification unknown
    • Whether NADH binding regulates decapping in vivo unresolved
    • Single lab
  13. 2015 Medium

    Provided a direct gene-disease link by showing a p.Phe54Ser variant that abolishes DCP2 stimulation causes intellectual disability.

    Evidence In vitro decapping with mutant EDC3 and homozygosity mapping in patients

    PMID:25701870

    Open questions at the time
    • Mechanism connecting decapping defect to neurodevelopmental phenotype unknown
    • Single family/lab
  14. 2016 High

    Captured the active decapping complex bound to Edc3 and product, providing direct structural proof that HLM binding stabilizes the catalytically competent DCP1-DCP2 conformation.

    Evidence Crystal structure of Dcp1-Dcp2-Edc3-m7GDP complex

    PMID:27694841

    Open questions at the time
    • Dynamics of the conformational switch in solution not addressed
  15. 2018 High

    Showed how Edc3 and Edc1 coactivators act simultaneously on Dcp2, with Edc1 bridging domains and Edc3 binding the HLM, and revealed substrate nucleotide selectivity.

    Evidence Crystal structure of Edc1-Dcp1-Dcp2-Edc3 with substrate analog, kinetics

    PMID:29559651

    Open questions at the time
    • Order and kinetics of coactivator assembly in cells unresolved
  16. 2021 High

    Identified Pim1/Pim3 as S161 kinases and tied the EDC3 phospho-switch to prostate cancer growth and integrin mRNA regulation, extending the AKT axis to oncogenic signaling.

    Evidence Kinase assays, S161A mutagenesis, P-body microscopy, xenografts, Western/RT-PCR

    PMID:33586867

    Open questions at the time
    • Direct mechanism linking P-body exclusion to integrin mRNA stabilization not fully resolved
  17. 2021 Medium

    Defined the FDF-FEK helicase-binding mode in C. elegans EDC-3, confirming conserved but distinct DDX6-family engagement relative to Tral/Pat1 orthologs.

    Evidence Homology modeling, ITC, mutagenesis, GST pulldown, microscopy

    PMID:34645931

    Open questions at the time
    • No experimental structure; single lab
    • Functional consequences in vivo not deeply tested
  18. 2022 Medium

    Discovered a stress-responsive Tyr-475 site that cross-talks with S161/S131 phosphorylation and remodels DDX6, DCP1, and 14-3-3 interactions while still supporting P-body formation.

    Evidence Chemical proteomics (SuTEx), mutagenesis, phosphoproteomics, co-IP, P-body rescue

    PMID:36476517

    Open questions at the time
    • Tyr-475 kinase/writer not identified
    • Functional output of the phospho cross-talk unclear
    • Single lab
  19. 2024 Medium

    Defined an organismal role in embryonic mRNA clearance and granule boundary maintenance, with EDC-4 antagonism, showing EDC3 shapes condensate identity in vivo.

    Evidence C. elegans knockouts, condensate microscopy, mRNA level measurements

    PMID:39331503

    Open questions at the time
    • Molecular basis of granule boundary definition unresolved
    • Single study
  20. 2024 Medium

    Revealed regulated turnover of Edc3 itself via Med13-dependent cargo-hitchhiking autophagy upon nitrogen starvation, adding a degradation layer to EDC3 regulation.

    Evidence Live colocalization microscopy, genetic deletions, autophagy assays in yeast

    PMID:39320938

    Open questions at the time
    • Whether this turnover pathway is conserved in metazoans unknown
    • Single lab
  21. 2025 Medium

    Established functional redundancy with Scd6 in recruiting Dhh1 to Dcp2, explaining why single-mutant decay defects are mild and linking decay/translation control to nutrient availability.

    Evidence RNA-seq and ribosome profiling of single/double mutants, decay and metabolic assays in yeast

    PMID:39257769 PMID:41289350

    Open questions at the time
    • Selection of redundant vs unique targets not defined
    • Conservation of redundancy in metazoans untested

Open questions

Synthesis pass · forward-looking unresolved questions
  • The physiological function of EDC3's NAD/NADH binding and the regulatory logic integrating S161, S131, and Y475 phosphorylation with decapping activity remain unresolved.
  • No identified endogenous substrate for the YjeF_N NAD activity
  • No structure of phosphorylated EDC3 or its 14-3-3 complex
  • Mechanism coupling P-body exclusion to specific mRNA stabilization undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 4 GO:0060090 molecular adaptor activity 3 GO:0003723 RNA binding 2
Localization
GO:0005829 cytosol 4
Pathway
R-HSA-8953854 Metabolism of RNA 4
Partners
14-3-3DCP1DCP2DDX6ME31BPIM1PIM3UPF1
Complex memberships
DCP1-DCP2 decapping complexP-body

Evidence

Reading pass · 21 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2007 The N-terminal LSm domain of EDC3 mediates DCP1 binding and P-body localization; crystal structures of Drosophila and human EDC3 LSm domains revealed a divergent Sm fold lacking the N-terminal alpha-helix and disrupted beta4-strand, remaining monomeric in solution; a conserved surface patch is required for DCP1 interaction but not P-body localization; the FDF motif mediates interaction with the C-terminal RecA-like domain of Me31B/DDX6; and the YjeF_N domain enables interaction with DCP2. NMR/crystal structure determination, mutagenesis, co-immunoprecipitation, P-body localization by fluorescence microscopy Molecular and cellular biology High 17923697
2008 In Drosophila cells, EDC3 and Trailer Hitch (Tral/LSm15) both interact with DCP1 and Me31B via their LSm and FDF domains, respectively, but only EDC3 (not Tral) associates with the decapping enzyme DCP2; both proteins localize to P-bodies via their LSm domains; the LSm domain of EDC3/Tral is monomeric and adopts a divergent Sm fold. Co-immunoprecipitation, NMR structure determination, mutational analysis, fluorescence microscopy Molecular and cellular biology High 18765641
2008 The YjeF_N domain of human EDC3 adopts a divergent Rossmann fold topology and forms a dimer in solution; dimerization is required for efficient RNA binding, P-body formation, and regulation of RPS28B mRNA in yeast. Crystal structure (2.2 Å), sedimentation velocity/equilibrium analysis, structure-based mutagenesis, P-body fluorescence assay, mRNA decay assay Molecular and cellular biology High 18678652
2009 Crystal structure of the DDX6 C-terminal RecA-like domain bound to the FDF motif of EDC3 shows the FDF peptide adopts an alpha-helical conformation occupying a groove on DDX6 opposite to the RNA/ATP interface; Tral contains a similar FDF motif and binds the same surface, making EDC3 and Tral interactions with DDX6/Me31B mutually exclusive; mutagenesis of Me31B's FDF-binding surface abolishes P-body accumulation and translational repression. Crystal structure determination, mutagenesis, competition assays, P-body fluorescence and translational repression assays Molecular cell High 19285948
2010 Edc3 binds Dcp2 via a short peptide sequence C-terminal to the Dcp2 catalytic domain; this interaction is required for Edc3 to stimulate Dcp2 decapping activity in vitro, for efficient Dcp2 accumulation in P-bodies, and for efficient degradation of the RPS28B mRNA; by contrast, YRA1 pre-mRNA degradation by Edc3 is independent of this Dcp2-binding region. In vitro decapping assay, deletion analysis, P-body fluorescence microscopy, mRNA decay assays in yeast Molecular and cellular biology High 20086104
2010 AKT phosphorylates EDC3 on Ser-161 downstream of insulin signaling; this phosphorylation increases 14-3-3 binding to EDC3, causes morphological changes in P-body structures, inhibits microRNA-mediated mRNA post-transcriptional regulation, and alters EDC3 protein-protein interactions. Quantitative phosphoproteomics, in vitro kinase assay (AKT), site-directed mutagenesis (S161), co-immunoprecipitation with 14-3-3, functional P-body and miRNA reporter assays Molecular & cellular proteomics : MCP High 20051463
2011 The yeast Edc3 LSm domain binds a short helical leucine-rich motif (HLM) in the disordered C-terminal extension of Dcp2 in an unprecedented manner via a noncanonical surface; Dcp2 contains multiple such HLMs that interact with Edc3; Edc3 stimulates decapping in vitro, likely by preventing the Dcp1:Dcp2 complex from adopting an inactive conformation; in metazoans the HLM is found in Dcp1 rather than Dcp2; the Edc3-related protein Scd6 competes with Edc3 for HLM binding. Crystal structure of yeast Edc3 LSm-Dcp2 HLM complex, in vitro decapping assay, mutagenesis, P-body localization assay The EMBO journal High 22085934
2011 Edc3 interacts with the N-terminal domain of Upf1 at a site overlapping but not identical to the Upf2-binding site, and this interaction is largely responsible for the indirect Dcp2-Upf1 two-hybrid interaction; Edc3 (along with Pat1, Edc1, Edc2) is not essential for general NMD under normal conditions. Yeast two-hybrid assay, deletion analysis, NMD reporter assays PloS one Medium 22065998
2013 Crystal structure (2.8 Å) of yeast Dhh1 bound to the N-terminal domain of Pat1 shows Pat1 wraps around the C-terminal RecA domain of Dhh1 at the FDF-binding site; Pat1 and Edc3 therefore compete for the same surface on Dhh1; both Pat1 and Edc3 also compete with RNA binding to Dhh1; mode of Dhh1-Pat1 recognition is conserved in humans. Crystal structure, co-immunoprecipitation with structure-based mutants, crosslinking-mass spectrometry RNA mapping, human validation by co-IP Nucleic acids research High 23851565
2013 Edc3 directly and tightly binds the globular core of the Rps28 ribosomal protein through a motif exclusive to Saccharomycetaceae Edc3 proteins; this Rps28-binding motif is required for Edc3-mediated autoregulatory decay of RPS28B mRNA but is dispensable for Edc3's general decapping function and YRA1 pre-mRNA decay regulation. Biochemical binding assays, mutational analysis, mRNA decay assays, phylogenetic analysis Nucleic acids research High 23956223
2014 Edc3 directly binds the 3'-UTR decay-inducing regulatory element of RPS28B mRNA (not Rps28b as previously thought); the Lsm and YjeF-N domains of Edc3 are both required for RPS28B mRNA decay, while only the Lsm domain is required for YRA1 pre-mRNA decay; Rps28b binds Edc3 and regulates its activity rather than binding mRNA directly. RNA-binding assays, domain deletion analysis, mRNA decay assays, co-immunoprecipitation in yeast Molecular and cellular biology High 24492965
2014 Human Edc3 directly binds NADH via its YjeF_N domain; both human and yeast Edc3 chemically modify NAD in vitro; mutations predicted to disrupt NAD-related molecule binding/hydrolysis affect mRNA degradation control and P-body composition in vivo. Crystal structure analysis, in vitro NADH binding assay, in vitro NAD modification assay, mutagenesis, P-body assay, mRNA decay assay G3 (Bethesda, Md.) Medium 24504254
2015 A homozygous missense mutation in human EDC3 (p.Phe54Ser) abolishes its ability to enhance DCP2 decapping at low concentrations and even inhibits DCP2 decapping at high concentrations in vitro, causing intellectual disability in affected individuals. In vitro decapping assay with mutant EDC3, human genetics (homozygosity mapping) Human molecular genetics Medium 25701870
2016 Crystal structure of the active form of yeast K. lactis Dcp1-Dcp2 enzyme bound to product m7GDP and activator Edc3 shows how Edc3 binding to the Dcp2 HLM stabilizes the active conformation of the decapping complex. Crystal structure determination of Dcp1-Dcp2-Edc3-m7GDP complex Nature structural & molecular biology High 27694841
2018 Crystal structure (2.84 Å) of K. lactis Edc1-Dcp1-Dcp2-Edc3 heterotetrameric complex with substrate analog in the Dcp2 active site shows how Edc3 and Edc1 coactivators act simultaneously: Edc1 forms a three-way interface bridging Dcp2 domains to consolidate the active conformation, while Edc3 binds Dcp2 HLM; kinetic data show Dcp2 has selectivity for the first transcribed nucleotide during catalysis. Crystal structure determination (2.84 Å), kinetic assays Nature communications High 29559651
2021 Pim1 and Pim3 protein kinases bind to EDC3 and phosphorylate EDC3 on Ser-161, blocking EDC3 localization to P-bodies; EDC3 S161A mutation markedly decreases prostate cancer cell growth, migration, and invasion in vitro and in xenograft models, associated with reduced integrin β1 and α6 mRNA and protein expression. Kinase binding and phosphorylation assays, EDC3 S161A mutagenesis, P-body fluorescence microscopy, xenograft models, Western blotting, RT-PCR EMBO reports High 33586867
2021 The C. elegans EDC-3 FDF-FEK motif interacts with the CGH-1 (DDX6 ortholog) RecA2 domain; the binding interface was characterized by homology modeling, ITC, and mutagenesis; EDC-3 and CAR-1/PATR-1 (Tral/Pat1 orthologs) have similar but distinct binding modes on CGH-1 RecA2. Homology modeling, ITC binding assay, mutagenesis, GST pulldown, co-localization fluorescence microscopy Scientific reports Medium 34645931
2022 Chemical proteomics identified EDC3 Tyr-475 (Y475) as a stress-responsive site; Y475 mutation causes hypo-phosphorylation at S161 and S131, alters protein-protein interactions with DDX6, DCP1A/B, and 14-3-3 proteins, yet this mutant form can rescue the P-body-deficient phenotype of EDC3 knockout cells. Chemical proteomics (SuTEx probes), mutagenesis, phosphoproteomics, co-immunoprecipitation, P-body fluorescence rescue assay Cell chemical biology Medium 36476517
2024 In C. elegans, EDC-3 facilitates timely removal of specific embryonic mRNAs (cgh-1, car-1, ifet-1) by reducing their expression levels and preventing excessive accumulation of DCAP-2 condensates in somatic cells; EDC-3 also defines boundaries between P bodies, germ granules, and stress granules; EDC-4 counteracts EDC-3 function. C. elegans genetic knockouts, fluorescence microscopy of condensate formation, mRNA level measurements Cell reports Medium 39331503
2024 In S. cerevisiae, Med13 (a Cdk8 kinase module scaffold) translocates to the cytoplasm upon nitrogen starvation and colocalizes with P-bodies, where it recruits Edc3 into P-bodies and orchestrates autophagic degradation of Edc3 through a selective cargo-hitchhiking autophagy pathway using Ksp1 as autophagic receptor; Xrn1 autophagic degradation is Med13-independent. Live fluorescence microscopy (colocalization), genetic deletion analysis, autophagy assays in yeast Molecular biology of the cell Medium 39320938
2025 Edc3 and Scd6 act redundantly as decapping activators that recruit Dhh1 to Dcp2; single mutants show limited mRNA decay defects while the double mutant reveals broad redundant targeting of mRNAs for degradation; Edc3/Scd6 also redundantly repress translation of specific transcripts and cooperate with Pat1 to adjust gene expression to nutrient availability. RNA-seq of single and double mutants, ribosome profiling, mRNA decay assays, metabolic measurements in yeast eLife Medium 39257769 41289350

Source papers

Stage 0 corpus · 30 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2009 Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B. Molecular cell 106 19285948
2011 The structural basis of Edc3- and Scd6-mediated activation of the Dcp1:Dcp2 mRNA decapping complex. The EMBO journal 101 22085934
2008 Similar modes of interaction enable Trailer Hitch and EDC3 to associate with DCP1 and Me31B in distinct protein complexes. Molecular and cellular biology 80 18765641
2013 Structural analysis of the yeast Dhh1-Pat1 complex reveals how Dhh1 engages Pat1, Edc3 and RNA in mutually exclusive interactions. Nucleic acids research 72 23851565
2007 A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting. Molecular and cellular biology 66 17923697
2008 Crystal structure of human Edc3 and its functional implications. Molecular and cellular biology 60 18678652
2010 Identification and analysis of the interaction between Edc3 and Dcp2 in Saccharomyces cerevisiae. Molecular and cellular biology 49 20086104
2016 Structure of the active form of Dcp1-Dcp2 decapping enzyme bound to m7GDP and its Edc3 activator. Nature structural & molecular biology 42 27694841
2015 Mutations in DCPS and EDC3 in autosomal recessive intellectual disability indicate a crucial role for mRNA decapping in neurodevelopment. Human molecular genetics 42 25701870
2010 Global phosphoproteomics identifies a major role for AKT and 14-3-3 in regulating EDC3. Molecular & cellular proteomics : MCP 39 20051463
2018 Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis. Nature communications 36 29559651
2021 EDC3 phosphorylation regulates growth and invasion through controlling P-body formation and dynamics. EMBO reports 30 33586867
2014 Yeast Edc3 targets RPS28B mRNA for decapping by binding to a 3' untranslated region decay-inducing regulatory element. Molecular and cellular biology 22 24492965
2011 Interactions between Upf1 and the decapping factors Edc3 and Pat1 in Saccharomyces cerevisiae. PloS one 22 22065998
2010 Distinct roles for Caf1, Ccr4, Edc3 and CutA in the co-ordination of transcript deadenylation, decapping and P-body formation in Aspergillus nidulans. Molecular microbiology 22 20233300
2013 Identification of the Rps28 binding motif from yeast Edc3 involved in the autoregulatory feedback loop controlling RPS28B mRNA decay. Nucleic acids research 18 23956223
2014 Roles of Edc3 in the oxidative stress response and CaMCA1-encoded metacaspase expression in Candida albicans. The FEBS journal 15 25158786
2016 The decapping activator Edc3 and the Q/N-rich domain of Lsm4 function together to enhance mRNA stability and alter mRNA decay pathway dependence in Saccharomyces cerevisiae. Biology open 11 27543059
2022 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell chemical biology 10 36476517
2016 Mutational analysis of metacaspase CaMca1 and decapping activator Edc3 in the pathogenicity of Candida albicans. Fungal genetics and biology : FG & B 10 27815149
2016 Melatonin-Mediated Intracellular Insulin during 2-Deoxy-d-glucose Treatment Is Reduced through Autophagy and EDC3 Protein in Insulinoma INS-1E Cells. Oxidative medicine and cellular longevity 8 27493704
2014 Edc3 function in yeast and mammals is modulated by interaction with NAD-related compounds. G3 (Bethesda, Md.) 8 24504254
2024 Med13 is required for efficient P-body recruitment and autophagic degradation of Edc3 following nitrogen starvation. Molecular biology of the cell 5 39320938
2024 EDC-3 and EDC-4 regulate embryonic mRNA clearance and biomolecular condensate specialization. Cell reports 5 39331503
2015 Deletion analysis of LSm, FDF, and YjeF domains of Candida albicans Edc3 in hyphal growth and oxidative-stress response. Journal of microbiology (Seoul, Korea) 5 25626365
2025 Decapping activators Edc3 and Scd6 act redundantly with Dhh1 in post-transcriptional repression of starvation-induced pathways. bioRxiv : the preprint server for biology 2 39257769
2025 EDC3 protein of P-body suppresses PRRSV proliferation and functions by upregulating MyD88. Veterinary microbiology 2 39938412
2025 Decapping activators Edc3 and Scd6 act redundantly with Dhh1 in post-transcriptional repression of starvation-induced pathways. eLife 2 41289350
2022 Assay to Study the Phase-transition Behavior of Edc3, a Conserved Processing Body (P-body) Marker Protein. Bio-protocol 2 36199703
2021 Insight into the interaction between the RNA helicase CGH-1 and EDC-3 and its implications. Scientific reports 2 34645931

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