Affinage

DHCR24

Delta(24)-sterol reductase · UniProt Q15392

Length
516 aa
Mass
60.1 kDa
Annotated
2026-06-09
100 papers in source corpus 36 papers cited in narrative 36 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

DHCR24 (seladin-1) is an FAD-dependent oxidoreductase of the ER membrane that catalyzes the terminal step of cholesterol biosynthesis, reducing desmosterol to cholesterol, and through this activity governs membrane cholesterol content and the integrity of cholesterol-rich detergent-resistant membrane domains (lipid rafts/caveolae) that organize downstream signaling (PMID:16410790, PMID:16407971, PMID:22178193). The enzyme adopts an N-terminal-luminal/C-terminal-cytoplasmic ER topology, with its N-terminal transmembrane domain required for ER targeting; its catalytic activity depends on phosphorylatable residues T110, Y299, and Y507 and is acutely inhibited by the endogenous oxysterol 24(S),25-epoxycholesterol independently of protein level (PMID:22010141, PMID:24363437, PMID:22178193). In vivo, DHCR24 loss is neonatally lethal with desmosterol-for-cholesterol replacement that disrupts epidermal differentiation and barrier function, establishing the enzyme's non-redundant role in cholesterol production (PMID:16410790). By maintaining raft/caveolae integrity, DHCR24 sustains caveolin-1-dependent receptor signaling and survival cascades—including insulin/IGF1R-Akt-Bad, Akt/GSK3β/mTOR, PP2A, and Ras/MEK/ERK—such that its depletion disrupts these axes and drives tau hyperphosphorylation, while it also partners physically with DHCR7 in a cholesterol-synthesis metabolon (PMID:16513830, PMID:33967735, PMID:33710538, PMID:35804281, PMID:25637936). Independently of cholesterol synthesis, DHCR24 binds the p53 N-terminus and displaces Mdm2 to stabilize p53, mediating responses to oncogenic and oxidative stress, and confers anti-apoptotic neuroprotection against amyloid-β, ER stress, and neuroinflammation in part by limiting caspase activation (PMID:15577914, PMID:17984220, PMID:24489783). Its expression is controlled by a broad transcriptional network—SREBP-2, LXR, CAR/PXR, AR, ER-alpha, STAT3, SOX9—and by the microRNAs miR-7 and miR-124 (PMID:22809995, PMID:18815215, PMID:22101211, PMID:18762779, PMID:18499757, PMID:28112250, PMID:34624089, PMID:37086967, PMID:31100313). DHCR24 functions upstream of LXRα in hepatic lipid and inflammatory homeostasis and serves as a required host factor for HCV replication (PMID:37357756, PMID:21184787).

Mechanistic history

Synthesis pass · year-by-year structured walk · 21 steps
  1. 2000 Medium

    Established the first cellular function of seladin-1 as an anti-apoptotic neuroprotective factor, framing the gene beyond a metabolic enzyme.

    Evidence functional expression in H4 neuroglioma cells with caspase-3 activity assays and immunoblot

    PMID:11007892

    Open questions at the time
    • Mechanism linking seladin-1 to caspase-3 inhibition not defined
    • Did not establish enzymatic basis or substrate
  2. 2004 High

    Revealed a cholesterol-independent tumor-suppressive mechanism: DHCR24 stabilizes p53 by binding its N-terminus and displacing Mdm2.

    Evidence genetic screen, reciprocal co-IP, interface mutagenesis, and transformation assays in fibroblasts

    PMID:15577914

    Open questions at the time
    • Structural basis of p53/Mdm2 interface binding not resolved
    • Relationship between this moonlighting function and the reductase activity unclear
  3. 2006 High

    Defined DHCR24 as the enzyme catalyzing desmosterol→cholesterol conversion essential in vivo, and linked its loss to lipid raft disruption and amyloidogenic APP processing.

    Evidence DHCR24 knockout mouse brain and epidermis analysis with sterol quantification, DRM fractionation, BACE assays, and differentiation markers

    PMID:16407971 PMID:16410790

    Open questions at the time
    • Enzyme kinetics and cofactor requirements not characterized here
    • Tissue-specific consequences beyond brain and skin not addressed
  4. 2006 High

    Connected DHCR24-dependent cholesterol to caveolae-organized insulin receptor/Akt-Bad survival signaling.

    Evidence DHCR24−/− MEFs with fractionation, phospho-Akt/Bad immunoblot, and cholesterol-repletion rescue

    PMID:16513830

    Open questions at the time
    • Direct molecular link between cholesterol and IR-caveolin co-localization not resolved
  5. 2007 High

    Distinguished two protective modes—cholesterol-dependent oxidative-stress resistance and cholesterol-independent p53 stabilization—using catalytic mutants.

    Evidence SH-SY5Y overexpression with reductase-activity mutants, p53 ubiquitination assays, and primary neuron knockdown with p53 rescue

    PMID:17984220

    Open questions at the time
    • How chronic stress switches between the two modes not defined
  6. 2008 Medium

    Mapped the transcriptional regulators of DHCR24, placing cholesterol synthesis under hormonal (ER-alpha, AR) and oxysterol (LXR) control.

    Evidence luciferase reporters, ChIP, promoter element analysis, and LXRβ-null/cell line expression

    PMID:18499757 PMID:18762779 PMID:18815215

    Open questions at the time
    • Direct AR binding not assayed in some studies
    • Tissue-specific contribution of each regulator not quantified
  7. 2008 Medium

    Showed DHCR24-driven membrane cholesterol limits amyloid-β plasma-membrane accumulation and calcium dysregulation.

    Evidence SH-SY5Y overexpression and seladin-1 inhibitor treatment with confocal Aβ imaging and Ca2+ imaging

    PMID:18194465

    Open questions at the time
    • Pharmacological inhibitor specificity not fully controlled
    • Direct membrane interaction mechanism not shown
  8. 2009 Medium

    Ordered the caspase-3/GGA3/BACE1 axis downstream of seladin-1 loss under apoptotic conditions, linking apoptosis to amyloidogenesis.

    Evidence siRNA knockdown in SH-SY5Y with caspase-3 assays, GGA3/BACE1 immunoblot, and Aβ ELISA

    PMID:19815556

    Open questions at the time
    • Effect confined to apoptotic conditions; physiological relevance unclear
  9. 2009 Medium

    Documented ACTH-induced nuclear relocalization of seladin-1 and a steroidogenic role in adrenal DHEA secretion.

    Evidence immunofluorescence, fractionation, U18666A inhibition, and steroid ELISA in rat and human fasciculata cells

    PMID:19520779

    Open questions at the time
    • Functional significance of nuclear relocalization not established
    • Species differences in localization unexplained
  10. 2010 High

    Identified DHCR24 as an obligate host factor for HCV replication and a druggable antiviral target.

    Evidence siRNA knockdown and U18666A inhibition in replicon/JFH-1 systems and humanized chimeric mice

    PMID:21184787

    Open questions at the time
    • Molecular step in HCV replication requiring DHCR24 not defined
  11. 2011 High

    Established post-translational and additional transcriptional control of DHCR24: acute oxysterol inhibition of activity and CAR/PXR transactivation.

    Evidence cell-based sterol quantification with overexpression rescue; reporter assays, EMSA, and in vivo phenobarbital induction

    PMID:22101211 PMID:22178193

    Open questions at the time
    • Molecular mechanism of 24,25EC inhibition of the enzyme not resolved
  12. 2012 Medium

    Resolved DHCR24 transcriptional, epigenetic, and topological regulation, establishing SREBP-2/NF-Y control, methylation/HDAC sensitivity, and ER membrane orientation.

    Evidence reporter assays, EMSA, ChIP, methylation analysis, and fluorescent protease protection topology assay

    PMID:20568014 PMID:22010141 PMID:22809995

    Open questions at the time
    • Functional consequence of ER topology for catalysis not defined
    • ER targeting dispensable for ROS scavenging—alternate localization not mapped
  13. 2013 High

    Identified specific phosphorylation sites (T110, Y299, Y507) and PKC-dependent regulation as post-translational controls of reductase activity.

    Evidence site-directed mutagenesis with ectopic human DHCR24 activity assay in CHO-7 cells and PKC inhibitor treatment

    PMID:24363437

    Open questions at the time
    • Responsible kinases not identified
    • Phosphorylation stoichiometry under physiological signaling unknown
  14. 2015 Medium

    Demonstrated a DHCR24-DHCR7 cholesterol metabolon and a brain-protective raft function maintaining EAAT2-mediated glutamate uptake.

    Evidence co-IP and reciprocal enzyme activity assays; Dhcr24+/− MCAO mice with raft fractionation and glutamate uptake assays

    PMID:25637936 PMID:26628388

    Open questions at the time
    • Direct substrate channeling between DHCR24 and DHCR7 not visualized
    • Stoichiometry of the metabolon unknown
  15. 2017 Medium

    Extended DHCR24 transcriptional control to insulin/STAT3 and linked it to cancer cell behavior.

    Evidence ChIP-PCR, luciferase reporter, siRNA knockdown, and migration assays in endometrial cancer cells

    PMID:28112250

    Open questions at the time
    • Whether metastatic effect depends on cholesterol synthesis vs. moonlighting function not separated
  16. 2018 Medium

    Mapped DHCR24 cardioprotection through PI3K/Akt/HKII anti-apoptotic signaling in dilated cardiomyopathy.

    Evidence heart-specific transgenic overexpression in DCM mice with pathway epistasis by PI3K/HKII inhibitors and apoptosis readouts

    PMID:30891546

    Open questions at the time
    • Whether protection requires cholesterol synthesis not tested with catalytic mutants
  17. 2019 Medium

    Identified the miR-124–Dhcr24 axis controlling cardiomyocyte apoptosis and infarction.

    Evidence miR-124 gain/loss in cardiomyocytes, 3'UTR reporter, and in vivo agomiR/antagomiR injection with apoptosis assays

    PMID:31100313

    Open questions at the time
    • miRNA targeting assay details limited
    • Direct 3'UTR binding only implied
  18. 2020 Medium

    Consolidated DHCR24 as an upstream regulator of microglial polarization (Akt/GSK3β) and as a cholesterol/raft-dependent driver of HCC invasion.

    Evidence lentiviral/siRNA manipulation with Akt-inhibitor epistasis in BV-2 cells; siRNA and genkwadaphnin inhibition with raft and xenograft assays in HCC

    PMID:32950573 PMID:32958824

    Open questions at the time
    • Direct molecular link from DHCR24 to Akt activation not defined
  19. 2021 Medium

    Defined the cholesterol/caveolae → Akt-GSK3β-mTOR and PP2A signaling cascades whose disruption by DHCR24 loss drives tau hyperphosphorylation and impaired autophagy.

    Evidence bidirectional knockdown/knock-in in SH-SY5Y with phospho-tau, PP2A/GSK3β markers, autophagy readouts, and enzymatic rescue

    PMID:33710538 PMID:33967735

    Open questions at the time
    • Causal hierarchy among Akt, PP2A, and mTOR nodes not fully ordered
    • In vivo relevance to tauopathy not tested here
  20. 2022 Medium

    Extended raft-dependent signaling to astrocytic Ras/MEK/ERK-driven tau pathology and identified SOX9 and SRSF3 as cancer-context regulators of DHCR24.

    Evidence bidirectional manipulation in astrocytes; ChIP-seq/rescue (SOX9) and siRNA/SFI003 ROS-axis assays (SRSF3) with xenografts

    PMID:34624089 PMID:35501301 PMID:35804281

    Open questions at the time
    • Cell-type specificity of each upstream regulator not generalized
    • Whether ROS effects are downstream of cholesterol loss vs. moonlighting not separated
  21. 2023 High

    Established DHCR24 as upstream of LXRα in hepatic lipid/inflammation control, identified a miR-7–cholesterol feedback loop, and demonstrated in vivo neuroprotection in an AD model.

    Evidence SH42 inhibition with LXRα-KO epistasis in APOE*3-Leiden.CETP mice; miR-7 manipulation with SREBP2 ChIP; AAV DHCR24 overexpression in 5xFAD mice

    PMID:37086967 PMID:37344916 PMID:37357756

    Open questions at the time
    • Mechanism by which desmosterol activates LXRα in vivo not fully dissected
    • Translational dosing/safety of DHCR24 modulation unaddressed

Open questions

Synthesis pass · forward-looking unresolved questions
  • How DHCR24's catalytic (cholesterol-synthesis) and moonlighting (p53-stabilizing, anti-caspase) functions are coordinated, and which is required in each disease context, remains unresolved.
  • No structural model of the enzyme or its p53/Mdm2 interface
  • No clean separation-of-function genetics across tissues
  • Kinases and signals controlling phosphorylation-dependent activity unidentified

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016491 oxidoreductase activity 4 GO:0140313 molecular sequestering activity 2
Localization
GO:0005886 plasma membrane 3 GO:0005783 endoplasmic reticulum 2
Pathway
R-HSA-5357801 Programmed Cell Death 4 R-HSA-1430728 Metabolism 3 R-HSA-162582 Signal Transduction 3 R-HSA-1643685 Disease 2
Partners
DHCR7MDM2TP53
Complex memberships
DHCR24-DHCR7 cholesterol metabolon

Evidence

Reading pass · 36 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2000 Seladin-1/DHCR24 inhibits caspase-3 activation in response to amyloid-beta toxicity and oxidative stress, protecting cells from apoptotic cell death; endogenous seladin-1 is cleaved to a 40 kDa derivative in a caspase-dependent manner during apoptosis. Functional expression in human neuroglioma H4 cells; caspase-3 activity assays; Western blotting The Journal of neuroscience Medium 11007892
2004 Following oncogenic and oxidative stress, Seladin-1/DHCR24 binds the p53 amino terminus and displaces the E3 ubiquitin ligase Mdm2 from p53, causing p53 accumulation. Seladin-1 also associates with Mdm2 independently of p53. Ablation of Seladin-1 bypasses Ras-induced senescence and allows cellular transformation; mutants disrupting association with p53 or Mdm2 lose this tumor-suppressive activity. Direct genetic screen; co-immunoprecipitation; loss-of-function (siRNA/ablation) in rodent and human fibroblasts; mutagenesis of interaction interfaces; transformation assays Nature High 15577914
2006 Seladin-1/DHCR24 is required for normal cholesterol biosynthesis and the formation of cholesterol-rich detergent-resistant membrane domains (DRMs/lipid rafts) in mouse brain. Seladin-1 deficiency displaces beta-secretase (BACE) from DRMs into APP-containing membrane fractions, increasing beta-cleavage of APP and Aβ levels; overexpression reverses this, inducing plasmin activation and reducing BACE processing. DHCR24 knockout mouse brain analysis; cholesterol quantification; DRM fractionation; BACE activity assays; Aβ ELISA; seladin-1 overexpression The EMBO journal High 16407971
2006 DHCR24 knockout mice die within hours of birth with lethal dermopathy; DHCR24-deficient epidermis lacks cholesterol (replaced by desmosterol) and shows loss of differentiation markers (abnormal keratin 6/14 expression, altered filaggrin/loricrin/involucrin), confirming DHCR24 catalyzes desmosterol→cholesterol conversion essential for epidermal differentiation and barrier function. Targeted gene disruption (DHCR24−/− mice); sterol quantification; immunohistochemistry for keratin/differentiation markers; trans-epidermal water loss measurement; Lucifer yellow permeability assay The Journal of investigative dermatology High 16410790
2006 DHCR24−/− mouse embryonic fibroblasts (MEFs) undergo apoptosis upon cholesterol depletion (serum withdrawal) due to disruption of caveolae and impaired insulin receptor (IR)–caveolin-1 co-localization, leading to inactivation of the Akt–Bad survival cascade. Cholesterol repletion rescues Akt activation and prevents apoptosis. DHCR24−/− MEF cultures; subcellular fractionation; immunocytochemistry; phospho-Akt/Bad Western blotting; insulin stimulation rescue experiments Endocrinology High 16513830
2007 DHCR24/seladin-1 overexpression confers resistance to oxidative stress in a cholesterol-dependent manner; mutating the reductase activity abolished this protective effect. Under chronic oxidative stress, low DHCR24 levels reduce p53 stability (via elevated p53 ubiquitination/degradation) independently of cholesterol, and DHCR24 ablation prevents neuronal apoptosis in a p53-dependent manner. Neuroblastoma SH-SY5Y cell overexpression; reductase-activity mutants; cholesterol quantification; p53 ubiquitination assays; primary neuron knockdown with p53 rescue Molecular and cellular biology High 17984220
2008 Seladin-1/DHCR24 overexpression increases membrane cholesterol content, reduces accumulation of Aβ42 pre-fibrillar aggregates at the plasma membrane, and prevents amyloid-induced cytosolic Ca2+ rise. Cholesterol depletion (with the specific seladin-1 inhibitor 5,22E-cholestadien-3-ol or methyl-β-cyclodextrin) has the opposite effect. SH-SY5Y neuroblastoma overexpression; PEG-cholesterol supplementation; seladin-1 inhibitor treatment; confocal microscopy of Aβ membrane accumulation; intracellular Ca2+ imaging Journal of cellular and molecular medicine Medium 18194465
2008 Seladin-1/DHCR24 is a fundamental mediator of estrogen (17β-estradiol, raloxifene, tamoxifen)-induced neuroprotection; siRNA silencing of seladin-1 abolishes estrogen protection against Aβ and oxidative stress toxicity and caspase-3 activation. Half-palindromic estrogen-responsive elements in the seladin-1 promoter confer functional estrogen receptor-alpha-mediated transcriptional activation. siRNA knockdown in fetal neuroepithelial cells; caspase-3 activity assays; luciferase reporter assay with ER-alpha co-transfection; bioinformatic promoter analysis Endocrinology Medium 18499757
2008 Seladin-1/DHCR24 is transcriptionally regulated by liver X receptor (LXR): an LXR response element was identified within the second intron of the DHCR24 gene that confers LXR-specific ligand responsiveness; seladin-1/DHCR24 expression is decreased in skin of LXRβ-null mice. Whole-genome ChIP for LXRα occupancy; luciferase reporter assays in HepG2 and HEK293 cells; LXRβ-null mouse gene expression Molecular pharmacology Medium 18815215
2008 Androgen receptor (AR) regulates seladin-1/DHCR24 expression via androgen-responsive element sequences in its promoter; metastatic AR-negative prostate cancer cells have reduced seladin-1/DHCR24 expression and cholesterol; androgen ablation in prostate cancer patients reduces seladin-1/DHCR24 expression. Promoter sequence analysis; AR-positive vs. AR-negative cell line comparison; patient tissue RT-PCR and androgen-ablation treatment cohort Laboratory investigation Medium 18762779
2009 Down-regulation of seladin-1 in SH-SY5Y cells under apoptotic conditions increases caspase-3 activity, which depletes the BACE1-sorting protein GGA3, leading to increased BACE1 protein levels and activity and enhanced amyloidogenic APP processing and Aβ production. These effects are not seen under normal growth conditions. siRNA knockdown in SH-SY5Y cells; caspase-3 activity assays; GGA3/BACE1 Western blotting; Aβ ELISA; apoptosis induction The Journal of biological chemistry Medium 19815556
2009 ACTH induces nuclear relocalization of seladin-1 in rat adrenal fasciculata cells (from cytoplasm/cis-Golgi to nucleus), which is blocked by the DHCR24 inhibitor U18666A. In human fasciculata cells, seladin-1 is primarily ER-localized. Inhibition of seladin-1 abolishes ACTH-induced DHEA secretion but not cortisol secretion, and reduces ACTH-induced 11β-hydroxylase expression in rats. Immunofluorescence; subcellular fractionation; U18666A pharmacological inhibition; steroid secretion measurements (ELISA); immunohistochemistry Endocrinology Medium 19520779
2010 DHCR24 expression is induced by HCV infection in human hepatocytes; siRNA silencing of DHCR24 decreases HCV replication in replicon lines and HCV JFH-1-infected cells; the DHCR24 inhibitor U18666A suppresses HCV replication in vitro and in humanized chimeric mice, with synergistic effect when combined with interferon. siRNA knockdown; U18666A pharmacological inhibition; HCV replicon and JFH-1 infection assays; chimeric mouse model with humanized liver Journal of hepatology High 21184787
2011 The endogenous oxysterol 24(S),25-epoxycholesterol (24,25EC) rapidly inhibits DHCR24 enzyme activity (not protein levels) to reduce cholesterol synthesis and cause desmosterol accumulation; this effect is independent of DHCR24 protein levels, is specific to certain C-25 oxysterols, and overexpression of DHCR24 blunts this inhibition. Cell-based cholesterol and desmosterol quantification; DHCR24 overexpression; genetic and pharmacological manipulation of 24,25EC levels; multiple mammalian cell lines Biochimica et biophysica acta High 22178193
2011 CAR (constitutive androstane receptor) and PXR transactivate DHCR24 expression; a DR4 motif in the human DHCR24 distal promoter was identified as a binding site for the CAR/RXRα and PXR/RXRα heterodimers, mechanistically linking xenobiotic-responsive nuclear receptors to cholesterol biosynthesis. Reporter gene assays in hepatoma cells; electrophoretic mobility-shift assay (EMSA); mouse liver activation by phenobarbital; CAR activation in cultured human hepatocytes Toxicology letters Medium 22101211
2012 DHCR24 transcription is regulated primarily through SREBP-2 binding to two cooperative sterol regulatory elements (SREs) in its promoter, assisted by NF-Y binding sites; sterol depletion activates DHCR24 transcription via this SREBP-2 mechanism. Luciferase reporter assays; EMSA; chromatin immunoprecipitation (ChIP); sterol-depletion experiments Biochimica et biophysica acta Medium 22809995
2012 Full-length DHCR24 localizes to the ER membrane with an N-terminal luminal/C-terminal cytoplasmic orientation (established by fluorescent protease protection assay); the N-terminal transmembrane domain is essential for ER membrane targeting. ER membrane targeting is NOT required for its ROS scavenging activity but the anti-apoptotic function of DHCR24 is associated with its cleavage by caspase. Fluorescent protease protection (FPP) assay; TM-domain deletion mutants; H2DCFDA ROS measurement; confocal fluorescence microscopy; caspase activity assay Journal of molecular endocrinology Medium 22010141
2012 DHCR24 promoter transcription is initiated from a single CpG-rich promoter regulated by DNA methylation in some cell types; histone deacetylase inhibition (sodium butyrate) increases DHCR24 expression by recruiting acetylated histones H3/H4 to an enhancer region at −1203/−665 bp, as demonstrated by ChIP. Reporter gene assays; ChIP with anti-acetyl-H3/H4 antibodies; HDAC inhibitor treatment; DNA methylation analysis Molecular biology reports Medium 20568014
2013 DHCR24 activity is regulated post-translationally by phosphorylation: mutation of residues T110, Y299, and Y507 inhibits DHCR24 enzymatic activity; inhibitors of protein kinase C ablate DHCR24 activity through a different (non-annotated phosphorylation site) mechanism. Site-directed mutagenesis of phosphorylation sites; ectopic human DHCR24 activity assay in CHO-7 cells (with siRNA knockdown of endogenous hamster DHCR24); PKC inhibitor treatment Journal of lipid research High 24363437
2014 DHCR24 overexpression protects neuronal N2A cells from ER stress-induced apoptosis by reducing caspase-12 activity, diminishing ER stress markers (Bip, CHOP), attenuating JNK/p38 activation, decreasing intracellular ROS, and promoting caveolae formation with improved caveolin-1/IGF1R co-localization. Adenoviral DHCR24 overexpression in N2A cells; tunicamycin-induced ER stress; caspase-12 assay; Western blotting for ER stress markers; H2DCFDA ROS assay; confocal microscopy PloS one Medium 24489783
2015 DHCR24 (seladin-1) maintains lipid raft integrity in the ischemic brain; genetic heterozygous deletion (Dhcr24+/−) or pharmacological inhibition enlarges infarct volume, increases neuroinflammatory mediators, and reduces the association of glutamate transporter EAAT2 with lipid rafts, impairing glutamate uptake. Dhcr24+/− mice with middle cerebral artery occlusion; U18666A pharmacological inhibition; infarct volume measurement; lipid raft fractionation Western blot; [3H]-glutamate uptake assay in astrocyte cultures Stroke High 26628388
2015 DHCR24 and DHCR7 (7-dehydrocholesterol reductase) physically interact by co-immunoprecipitation; DHCR24 knockdown ablates DHCR7 enzymatic activity, and DHCR24 overexpression (functional form only) enhances DHCR7 activity, indicating a functional cholesterol 'metabolon' with substrate channeling. Co-immunoprecipitation; siRNA knockdown of DHCR24; DHCR7 enzymatic activity assay; overexpression of functional vs. non-functional DHCR24 Journal of lipid research Medium 25637936
2017 Insulin induces DHCR24 expression through STAT3, which directly binds to the DHCR24 promoter (demonstrated by ChIP-PCR and luciferase assay); silencing DHCR24 inhibits endometrial cancer cell metastasis and upregulates progesterone receptor (PGR) expression. ChIP-PCR; luciferase reporter assay; siRNA knockdown; cell migration assays; PGR Western blotting Scientific reports Medium 28112250
2017 DHCR24 overexpression protects neurons against LPS/IFN-γ-induced neuroinflammatory death in co-cultures and increases neuroligin-1 levels, dendritic spine density, and the proportion of mushroom spines; in vivo, DHCR24 overexpression in striatum reduces ischemic lesion size in a mouse transient focal ischemia model. Neuronal–microglial co-culture with LPS/IFN-γ; adeno-associated virus DHCR24 overexpression in vivo; MRI infarct measurement; dendritic spine morphology analysis; Western blotting for neuroligin-1 Journal of neuroinflammation Medium 29115990
2018 Dhcr24 overexpression protects against dilated cardiomyopathy (DCM) in cTnTR141W transgenic mice by activating the PI3K/Akt/HKII pathway and reducing Bax translocation, cytochrome c release, and caspase-9/caspase-3 activation. PI3K inhibition completely removes the anti-apoptotic effect; HKII inhibition only partially reduces it. Heart-specific transgenic Dhcr24 overexpression in DCM mice; Western blotting for PI3K/Akt/HKII pathway; TUNEL assay; echocardiography; PI3K and HKII inhibitors in H9c2 cells Animal models and experimental medicine Medium 30891546
2019 miR-124 directly targets Dhcr24 in cardiomyocytes; miR-124 overexpression increases cardiomyocyte apoptosis, which is mediated through downregulation of Dhcr24; miR-124 inhibition attenuates cell death; the miR-124–Dhcr24 axis regulates oxidative stress- and hypoxia-induced cardiomyocyte apoptosis and myocardial infarction in vivo. miR-124 overexpression/inhibition in cardiomyocytes; 3'UTR luciferase reporter (implied by target identification); in vivo intra-myocardial agomiR/antagomiR injection; apoptosis assays Journal of molecular and cellular cardiology Medium 31100313
2020 Genkwadaphnin (GD) suppresses DHCR24 expression and enzymatic activity, thereby inhibiting DHCR24-mediated cholesterol biosynthesis and lipid raft formation, which reduces HCC cell invasion and migration in vitro and tumor growth in vivo. DHCR24 siRNA knockdown; GD pharmacological inhibition; cholesterol level measurement; lipid raft structural assay; HCC xenograft in BALB/c nude mice; microarray gene expression British journal of cancer Medium 32958824
2020 DHCR24 overexpression in BV-2 microglia treated with Aβ25-35 reverses M1 polarization toward M2 phenotype and activates the Akt/GSK3β signaling pathway; co-treatment with the Akt inhibitor MK2206 reverses the effect of DHCR24, placing DHCR24 upstream of Akt/GSK3β in microglial inflammatory regulation. Lentiviral DHCR24 overexpression in BV-2 cells; Western blotting for P-Akt and P-GSK3β; cytokine (iNOS, IL-1β, TNF-α, arginase-1, IL-4, TGF-β) measurement; Akt inhibitor epistasis Life sciences Medium 32950573
2021 DHCR24 knockdown in SH-SY5Y cells reduces plasma membrane cholesterol and caveolin-1, disrupts lipid rafts/caveolae, decreases PI3-K/Akt signaling (reduced p-Akt at Thr308 and Ser473), activates GSK3β, and activates mTOR, leading to tau hyperphosphorylation at Thr181, Ser199, Thr231, Ser262, Ser396 and inhibition of autophagy; DHCR24 knock-in reverses all these effects. siRNA knockdown and overexpression (knock-in); Western blotting for cholesterol, caveolin-1, p-Akt, p-GSK3β, p-mTOR, LC3-II/I, p62; phospho-tau Western blotting; autophagosome counting Frontiers in aging neuroscience Medium 33967735
2021 DHCR24 knockdown in SH-SY5Y cells decreases plasma membrane cholesterol and caveolin-1, inhibiting PP2A activity (via increased p-PP2Ac at Y307) and activating GSK3β (via increased p-GSK3β at Y216), leading to tau hyperphosphorylation at multiple sites (Thr181, Thr231, Ser262, Ser396, Ser422); PP2A activator D-erythro-Sphingosine reverses the tau hyperphosphorylation induced by DHCR24 knockdown. siRNA knockdown and DHCR24 overexpression; Western blotting for PP2A activity markers, GSK3β, and phospho-tau; Filipin III cholesterol staining; PP2A activator rescue experiment Neurochemical research Medium 33710538
2022 SOX9 directly transcriptionally activates DHCR24 expression in diffuse large B-cell lymphomas (DLBCL) bearing IGH-BCL2 translocations, as shown by whole-transcriptome analysis and ChIP-seq; enforced DHCR24 expression rescues cell proliferation after SOX9 knockdown; DHCR24 mediates SOX9-driven cholesterol synthesis and lymphomagenesis. Whole-transcriptome analysis; ChIP-seq; SOX9 siRNA knockdown; DHCR24 forced expression rescue; xenograft tumor model Blood High 34624089
2022 SRSF3 directly regulates DHCR24 expression in colorectal cancer; SRSF3 silencing suppresses DHCR24, and the SRSF3 inhibitor SFI003 drives apoptosis via the SRSF3/DHCR24/ROS axis; elevated ROS upon DHCR24 reduction mediates the anticancer effect. SRSF3 siRNA knockdown; SFI003 pharmacological inhibition; DHCR24 expression measurement; ROS quantification; in vitro and in vivo xenograft assays Cell death discovery Medium 35501301
2022 DHCR24 knockdown in C8D1A astrocytes decreases cholesterol in plasma membrane and intracellular organelles, reduces caveola-associated protein cavin1, disrupts lipid rafts/caveolae, and activates the caveolae-dependent Ras/MEK/ERK signaling pathway, leading to tau hyperphosphorylation at Thr181, Ser199, Thr231, Ser262, Ser396; DHCR24 overexpression prevents ERK overactivation and tau hyperphosphorylation. siRNA knockdown and overexpression in C8D1A astrocytes; Filipin III staining; Western blotting for cavin1, Ras/MEK/ERK pathway, phospho-tau; cholesterol quantification Molecular neurobiology Medium 35804281
2023 miR-7 post-transcriptionally suppresses DHCR24 expression by targeting its 3'UTR, thereby blocking the last steps of cholesterol biosynthesis; intracranial AAV-delivered miR-7 reduces DHCR24 in mouse brain. Cholesterol reciprocally regulates miR-7 levels through SREBP2-mediated transcription, establishing a feedback loop. In vitro miR-7 overexpression; AAV intracranial delivery in mice; DHCR24 expression measurement; SREBP2 ChIP on miR-7 host gene promoter; Niemann Pick C1 mouse model and fatty liver model Biochimica et biophysica acta. Gene regulatory mechanisms Medium 37086967
2023 Pharmacological inhibition of DHCR24 by SH42 increases desmosterol in liver and plasma, activates LXRα, reduces hepatic lipid content and steatosis, decreases Kupffer cell activation and monocyte infiltration, and reduces liver collagen and ALT levels; LXRα deficiency completely abolishes all beneficial effects of SH42, placing DHCR24 upstream of LXRα in NAFLD/NASH regulation. APOE*3-Leiden.CETP mouse model; SH42 pharmacological inhibition; desmosterol quantification; flow cytometry; LXRα knockout mice; liver histology; collagen/ALT measurements EMBO molecular medicine High 37357756
2023 AAV-mediated DHCR24 overexpression in hippocampus of 5xFAD mice increases cholesterol, reverses cognitive impairment, reduces amyloid-β deposition, synaptic injury, autophagy dysfunction, reactive astrocytosis, microglial phagocytosis abnormalities, and apoptosis. AAV hippocampal delivery in 5xFAD mice; cholesterol quantification; behavioral tests; immunohistochemistry for Aβ, synaptic, autophagy, and apoptotic markers Acta neuropathologica communications Medium 37344916

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2017 Intratumoral and peritumoral radiomics for the pretreatment prediction of pathological complete response to neoadjuvant chemotherapy based on breast DCE-MRI. Breast cancer research : BCR 512 28521821
2000 The human DIMINUTO/DWARF1 homolog seladin-1 confers resistance to Alzheimer's disease-associated neurodegeneration and oxidative stress. The Journal of neuroscience : the official journal of the Society for Neuroscience 240 11007892
2004 Regulation of cellular response to oncogenic and oxidative stress by Seladin-1. Nature 165 15577914
2006 The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and Abeta generation in vivo. The EMBO journal 152 16407971
2013 Desmosterol and DHCR24: unexpected new directions for a terminal step in cholesterol synthesis. Progress in lipid research 134 24095826
2007 Dynamic contrast-enhanced ultrasonography (DCE-US) with quantification of tumor perfusion: a new diagnostic tool to evaluate the early effects of antiangiogenic treatment. European radiology 111 18376462
2010 Dynamic contrast-enhanced ultrasonography (DCE-US): a new tool for the early evaluation of antiangiogenic treatment. Targeted oncology 80 20379790
2002 Seladin-1 transcription is linked to neuronal degeneration in Alzheimer's disease. Neuroscience 79 12127087
2018 Breast cancer Ki67 expression prediction by DCE-MRI radiomics features. Clinical radiology 78 29970244
2007 Prosurvival effect of DHCR24/Seladin-1 in acute and chronic responses to oxidative stress. Molecular and cellular biology 78 17984220
2015 The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally. Journal of lipid research 76 25637936
2013 Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis. Journal of lipid research 63 24363437
2006 DHCR24 gene knockout mice demonstrate lethal dermopathy with differentiation and maturation defects in the epidermis. The Journal of investigative dermatology 63 16410790
2011 Evaluation of KRAS mutations, angiogenic biomarkers, and DCE-MRI in patients with advanced non-small-cell lung cancer receiving sorafenib. Clinical cancer research : an official journal of the American Association for Cancer Research 61 21224376
2008 Seladin-1 is a fundamental mediator of the neuroprotective effects of estrogen in human neuroblast long-term cell cultures. Endocrinology 60 18499757
2008 Neuroprotective effects of the Alzheimer's disease-related gene seladin-1. Journal of molecular endocrinology 60 18768664
2009 Down-regulation of seladin-1 increases BACE1 levels and activity through enhanced GGA3 depletion during apoptosis. The Journal of biological chemistry 59 19815556
2006 Neuronal differentiation of human mesenchymal stem cells: changes in the expression of the Alzheimer's disease-related gene seladin-1. Experimental cell research 58 16762343
2017 Glioma Grading and Determination of IDH Mutation Status and ATRX loss by DCE and ASL Perfusion. Clinical neuroradiology 57 28488024
2010 Augmentation of DHCR24 expression by hepatitis C virus infection facilitates viral replication in hepatocytes. Journal of hepatology 56 21184787
2016 Correlations Between DCE MRI and Histopathological Parameters in Head and Neck Squamous Cell Carcinoma. Translational oncology 54 27888709
2008 Seladin-1/DHCR24 protects neuroblastoma cells against Abeta toxicity by increasing membrane cholesterol content. Journal of cellular and molecular medicine 54 18194465
2005 Expression of the antiapoptotic gene seladin-1 and octreotide-induced apoptosis in growth hormone-secreting and nonfunctioning pituitary adenomas. The Journal of clinical endocrinology and metabolism 52 16091489
2019 MicroRNA-124 regulates cardiomyocyte apoptosis and myocardial infarction through targeting Dhcr24. Journal of molecular and cellular cardiology 50 31100313
2012 Correlation of a priori DCE-MRI and (1)H-MRS data with molecular markers in neck nodal metastases: Initial analysis. Oral oncology 50 22366441
2006 Relationship between DCE-MRI morphological and functional features and histopathological characteristics of breast cancer. European radiology 50 17149623
2019 Differential diagnosis of nasopharyngeal carcinoma and nasopharyngeal lymphoma based on DCE-MRI and RESOLVE-DWI. European radiology 49 31372786
2017 Cholesterol Synthetase DHCR24 Induced by Insulin Aggravates Cancer Invasion and Progesterone Resistance in Endometrial Carcinoma. Scientific reports 49 28112250
2022 DCE-MRI Radiomics Analysis in Differentiating Luminal A and Luminal B Breast Cancer Molecular Subtypes. Academic radiology 48 35595629
2020 Genkwadaphnin inhibits growth and invasion in hepatocellular carcinoma by blocking DHCR24-mediated cholesterol biosynthesis and lipid rafts formation. British journal of cancer 47 32958824
2006 DHCR24-knockout embryonic fibroblasts are susceptible to serum withdrawal-induced apoptosis because of dysfunction of caveolae and insulin-Akt-Bad signaling. Endocrinology 47 16513830
2011 The endogenous regulator 24(S),25-epoxycholesterol inhibits cholesterol synthesis at DHCR24 (Seladin-1). Biochimica et biophysica acta 46 22178193
2022 The role of DHCR24 in the pathogenesis of AD: re-cognition of the relationship between cholesterol and AD pathogenesis. Acta neuropathologica communications 45 35296367
2020 DSC and DCE Histogram Analyses of Glioma Biomarkers, Including IDH, MGMT, and TERT, on Differentiation and Survival. Academic radiology 45 31983532
2017 DHCR24 exerts neuroprotection upon inflammation-induced neuronal death. Journal of neuroinflammation 45 29115990
2019 Gastric cancer and image-derived quantitative parameters: Part 2-a critical review of DCE-MRI and 18F-FDG PET/CT findings. European radiology 44 31392480
2008 Androgen receptor regulation of the seladin-1/DHCR24 gene: altered expression in prostate cancer. Laboratory investigation; a journal of technical methods and pathology 43 18762779
2008 The selective Alzheimer's disease indicator-1 gene (Seladin-1/DHCR24) is a liver X receptor target gene. Molecular pharmacology 41 18815215
2018 Correlation between DCE-MRI radiomics features and Ki-67 expression in invasive breast cancer. Oncology letters 40 30250576
2008 Thyroid hormones promote cell differentiation and up-regulate the expression of the seladin-1 gene in in vitro models of human neuronal precursors. The Journal of endocrinology 40 18434374
2022 Oncogenic role of the SOX9-DHCR24-cholesterol biosynthesis axis in IGH-BCL2+ diffuse large B-cell lymphomas. Blood 38 34624089
2008 Intermittent high glucose concentrations reduce neuronal precursor survival by altering the IGF system: the involvement of the neuroprotective factor DHCR24 (Seladin-1). The Journal of endocrinology 35 18612048
2014 3 β-hydroxysteroid-Δ 24 reductase (DHCR24) protects neuronal cells from apoptotic cell death induced by endoplasmic reticulum (ER) stress. PloS one 34 24489783
2023 Inhibition of DHCR24 activates LXRα to ameliorate hepatic steatosis and inflammation. EMBO molecular medicine 33 37357756
2019 Associations between Histogram Analysis Parameters Derived from DCE-MRI and Histopathological Features including Expression of EGFR, p16, VEGF, Hif1-alpha, and p53 in HNSCC. Contrast media & molecular imaging 33 30718984
2012 Sterols regulate 3β-hydroxysterol Δ24-reductase (DHCR24) via dual sterol regulatory elements: cooperative induction of key enzymes in lipid synthesis by Sterol Regulatory Element Binding Proteins. Biochimica et biophysica acta 33 22809995
2021 DCE-MRI in Glioma, Infiltration Zone and Healthy Brain to Assess Angiogenesis: A Biopsy Study. Clinical neuroradiology 31 33900414
2021 DHCR24 Knock-Down Induced Tau Hyperphosphorylation at Thr181, Ser199, Thr231, Ser262, Ser396 Epitopes and Inhibition of Autophagy by Overactivation of GSK3β/mTOR Signaling. Frontiers in aging neuroscience 31 33967735
2019 Neuroinflammatory Reactions in the Brain of 1,2-DCE-Intoxicated Mice during Brain Edema. Cells 31 31461951
2021 DCE-MRI quantitative transport mapping for noninvasively detecting hypoxia inducible factor-1α, epidermal growth factor receptor overexpression, and Ki-67 in nasopharyngeal carcinoma patients. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 30 34592360
2023 DHCR24 reverses Alzheimer's disease-related pathology and cognitive impairment via increasing hippocampal cholesterol levels in 5xFAD mice. Acta neuropathologica communications 28 37344916
2009 New insights on the neuroprotective role of sterols and sex steroids: the seladin-1/DHCR24 paradigm. Frontiers in neuroendocrinology 28 19351544
2012 The membrane topological analysis of 3β-hydroxysteroid-Delta24 reductase (DHCR24) on endoplasmic reticulum. Journal of molecular endocrinology 27 22010141
2024 TREM2 alleviates white matter injury after traumatic brain injury in mice might be mediated by regulation of DHCR24/LXR pathway in microglia. Clinical and translational medicine 26 38649789
2022 A novel SRSF3 inhibitor, SFI003, exerts anticancer activity against colorectal cancer by modulating the SRSF3/DHCR24/ROS axis. Cell death discovery 26 35501301
2022 A radiomics model based on DCE-MRI and DWI may improve the prediction of estimating IDH1 mutation and angiogenesis in gliomas. European journal of radiology 25 34995947
2020 DHCR24 overexpression modulates microglia polarization and inflammatory response via Akt/GSK3β signaling in Aβ25-35 treated BV-2 cells. Life sciences 25 32950573
2010 Identification and analysis of the promoter region of the human DHCR24 gene: involvement of DNA methylation and histone acetylation. Molecular biology reports 25 20568014
2022 Dehydrocholesterol Reductase 24 (DHCR24): Medicinal Chemistry, Pharmacology and Novel Therapeutic Options. Current medicinal chemistry 23 34781860
2022 DHCR24 Knockdown Induces Tau Hyperphosphorylation at Thr181, Ser199, Ser262, and Ser396 Sites via Activation of the Lipid Raft-Dependent Ras/MEK/ERK Signaling Pathway in C8D1A Astrocytes. Molecular neurobiology 23 35804281
2012 Is seladin-1 really a selective Alzheimer's disease indicator? Journal of Alzheimer's disease : JAD 23 22387408
2010 Inhibition of DHCR24/seladin-1 impairs cellular homeostasis in prostate cancer. The Prostate 23 20166102
2008 Increased expression of aquaporin-3 in the epidermis of DHCR24 knockout mice. The British journal of dermatology 23 18241265
2005 Seladin-1/DHCR24 expression in normal ovary, ovarian epithelial and granulosa tumours. Clinical endocrinology 23 15963070
2017 Upregulation of seladin-1 and nestin expression in bone marrow mesenchymal stem cell transplantation via the ERK1/2 and PI3K/Akt signaling pathways in an Alzheimer's disease model. Oncology letters 22 29731895
2015 Seladin-1/DHCR24 Is Neuroprotective by Associating EAAT2 Glutamate Transporter to Lipid Rafts in Experimental Stroke. Stroke 22 26628388
2018 Dhcr24 activates the PI3K/Akt/HKII pathway and protects against dilated cardiomyopathy in mice. Animal models and experimental medicine 20 30891546
2012 Promoter analysis of the DHCR24 (3β-hydroxysterol Δ(24)-reductase) gene: characterization of SREBP (sterol-regulatory-element-binding protein)-mediated activation. Bioscience reports 20 23050906
2011 Constitutive androstane receptor transactivates the hepatic expression of mouse Dhcr24 and human DHCR24 encoding a cholesterogenic enzyme 24-dehydrocholesterol reductase. Toxicology letters 20 22101211
2009 24-dehydrocholesterol reductase/seladin-1: a key protein differentially involved in adrenocorticotropin effects observed in human and rat adrenal cortex. Endocrinology 20 19520779
2008 Homology modelling of human DHCR24 (seladin-1) and analysis of its binding properties through molecular docking and dynamics simulations. Steroids 20 18394665
2007 The association study between DHCR24 polymorphisms and Alzheimer's disease. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 20 17510943
2024 Enhancing pathological complete response prediction in breast cancer: the role of dynamic characterization of DCE-MRI and its association with tumor heterogeneity. Breast cancer research : BCR 19 38745321
2017 Data-driven mapping of hypoxia-related tumor heterogeneity using DCE-MRI and OE-MRI. Magnetic resonance in medicine 19 28856728
2007 Seladin-1 expression in rat adrenal gland: effect of adrenocorticotropic hormone treatment. The Journal of endocrinology 19 17210742
2021 Dynamic contrast-enhanced MRI of nasopharyngeal carcinoma: correlation of quantitative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters with hypoxia-inducible factor 1α expression and tumor grade/stage. Annals of palliative medicine 18 33725777
2017 Histogram analysis parameters identify multiple associations between DWI and DCE MRI in head and neck squamous cell carcinoma. Magnetic resonance imaging 18 28963049
2020 The effect of baicalein-loaded Y-shaped miktoarm copolymer on spatial memory and hippocampal expression of DHCR24, SELADIN and SIRT6 genes in rat model of Alzheimer. International journal of pharmaceutics 17 32544519
2019 Detection of Local Recurrence in Patients with Head and Neck Squamous Cell Carcinoma Using Voxel-Based Color Maps of Initial and Final Area under the Curve Values Derived from DCE-MRI. AJNR. American journal of neuroradiology 17 31320461
2014 DHT inhibits the Aβ25-35-induced apoptosis by regulation of seladin-1, survivin, XIAP, bax, and bcl-xl expression through a rapid PI3-K/Akt signaling in C6 glial cell lines. Neurochemical research 17 25347962
2014 Hippocampal DHCR24 down regulation in a rat model of streptozotocin-induced cognitive decline. Neuroscience letters 17 25541351
2023 "MiR-7 controls cholesterol biosynthesis through posttranscriptional regulation of DHCR24 expression". Biochimica et biophysica acta. Gene regulatory mechanisms 15 37086967
2020 Effects of chronic hypoxia on the expression of seladin-1/Tuj1 and the number of dark neurons of hippocampus. Journal of chemical neuroanatomy 15 31926979
2024 DHCR24 in Tumor Diagnosis and Treatment: A Comprehensive Review. Technology in cancer research & treatment 14 38847653
2021 DHCR24 Knockdown Lead to Hyperphosphorylation of Tau at Thr181, Thr231, Ser262, Ser396, and Ser422 Sites by Membrane Lipid-Raft Dependent PP2A Signaling in SH-SY5Y Cells. Neurochemical research 14 33710538
2019 Inhibition of DHCR24 increases the cisplatin-induced damage to cochlear hair cells in vitro. Neuroscience letters 14 31091460
2015 Serum DHCR24 Auto-antibody as a new Biomarker for Progression of Hepatitis C. EBioMedicine 14 26288822
2014 DHCR24 is an independent predictor of progression in patients with non-muscle-invasive urothelial carcinoma, and its functional role is involved in the aggressive properties of urothelial carcinoma cells. Annals of surgical oncology 14 24562935
2012 Testosterone up-regulates seladin-1 expression by iAR and PI3-K/Akt signaling pathway in C6 cells. Neuroscience letters 14 22405892
2009 Seladin-1 and testicular germ cell tumours: new insights into cisplatin responsiveness. The Journal of pathology 14 19844922
2022 Diagnosis and differential diagnosis of dermatofibrosarcoma protuberans: Utility of high-resolution dynamic contrast-enhanced (DCE) MRI. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 13 35639715
2021 Potential of combination of DCE-MRI and DWI with serum CA125 and CA199 in evaluating effectiveness of neoadjuvant chemotherapy in breast cancer. World journal of surgical oncology 13 34537053
2020 18F-FDG PET and DCE kinetic modeling and their correlations in primary NSCLC: first voxel-wise correlative analysis of human simultaneous [18F]FDG PET-MRI data. EJNMMI research 13 32734484
2019 Quantifying disease activity in rheumatoid arthritis with the TSPO PET ligand 18F-GE-180 and comparison with 18F-FDG and DCE-MRI. EJNMMI research 13 31858293
2018 Apolipoprotein M induces inhibition of inflammatory responses via the S1PR1 and DHCR24 pathways. Molecular medicine reports 13 30569161
2012 Simvastatin modulates the Alzheimer's disease-related gene seladin-1. Journal of Alzheimer's disease : JAD 13 21987590
2009 [Seladin-1/DHCR24: a key protein of cell homeostasis and cholesterol biosynthesis]. Postepy higieny i medycyny doswiadczalnej (Online) 13 19597241
2022 Hsa_circ_0003221 facilitates the malignant development of bladder cancer cells via resulting in the upregulation of DHCR24 by targeting miR-892b. Investigative and clinical urology 12 36068004
2022 DCE-MRI radiomics models predicting the expression of radioresistant-related factors of LRP-1 and survivin in locally advanced rectal cancer. Frontiers in oncology 12 36106114
2022 Augmentation of 3β-hydroxysteroid-Δ24 Reductase (DHCR24) Expression Induced by Bovine Viral Diarrhea Virus Infection Facilitates Viral Replication via Promoting Cholesterol Synthesis. Journal of virology 12 36468862

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