Affinage

CUL4B

Cullin-4B · UniProt Q13620

Length
913 aa
Mass
104.0 kDa
Annotated
2026-04-28
100 papers in source corpus 40 papers cited in narrative 39 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CUL4B is the scaffold subunit of the CRL4B cullin-RING E3 ubiquitin ligase complex (assembled with DDB1 and ROC1) that both polyubiquitinates substrates for proteasomal degradation and catalyzes H2AK119 monoubiquitination at gene promoters to epigenetically silence tumor suppressors, microRNAs, and differentiation regulators in coordination with PRC2-mediated H3K27 trimethylation and HDAC-containing corepressor complexes (PMID:19801544, PMID:25430888, PMID:28164432, PMID:34026424). Validated CRL4B degradation substrates include cyclin E, p21, TSC2, PPARγ, Jab1/CSN5, HUWE1, p53, INSL6, UTX, MEN1, AHR, and ARID1A, through which CUL4B controls cell cycle progression, mTOR signaling, adipogenesis, DNA damage responses, and cellular differentiation (PMID:22606329, PMID:23348097, PMID:27899484, PMID:25883150, PMID:37679762, PMID:36939378, PMID:34146543). A unique phosphorylatable N-terminal extension containing an NLS (KKRK, aa 37–40) mediates importin-α-dependent nuclear entry and, during mitosis, undergoes phosphorylation that recruits CUL4B-specific DCAFs LIS1 and WDR1 for spindle positioning and cortical tension control; the XLID-causing P50L mutation perturbs this phosphorylation (PMID:19801544, PMID:37365982). Loss-of-function mutations in CUL4B cause X-linked intellectual disability, and conditional knockouts in mice recapitulate tissue-specific defects including embryonic lethality, precocious neuronal differentiation via PP2A derepression, male infertility, aberrant myeloid-derived suppressor cell expansion, and metabolic dysregulation (PMID:17236139, PMID:38331954, PMID:26846852, PMID:26450912, PMID:27899484).

Mechanistic history

Synthesis pass · year-by-year structured walk · 18 steps
  1. 2007 High

    The fundamental question of what CUL4B encodes was answered: truncating and missense mutations destroying the C-terminal cullin domain cause X-linked intellectual disability, establishing CUL4B as an E3 ubiquitin ligase scaffold essential for human cognition and development.

    Evidence Mutation identification across multiple XLID families with demonstration of nonsense-mediated mRNA decay in patient leukocytes

    PMID:17236139 PMID:17273978

    Open questions at the time
    • Substrate specificity unknown at this stage
    • Mechanism linking ubiquitin ligase loss to intellectual disability not defined
    • No animal model yet available
  2. 2009 High

    The basis for CUL4B's nuclear-specific function was revealed: a unique N-terminal NLS (KKRK, aa 37–40) binds importins α1/α3/α5 and is required for nuclear entry, cyclin E ubiquitination, and cell proliferation — distinguishing CUL4B from its paralog CUL4A.

    Evidence NLS deletion mutagenesis, importin binding assays, cyclin E ubiquitination and cell proliferation assays

    PMID:19801544

    Open questions at the time
    • Structural basis of NLS–importin interaction not resolved
    • Whether additional signals regulate nuclear–cytoplasmic partitioning unknown
  3. 2012 High

    In vivo genetic confirmation that CUL4B is essential for embryogenesis and directly ubiquitinates cyclin E and p21 came from knockout mouse models showing embryonic lethality with substrate accumulation and G2/M arrest.

    Evidence Cul4b-null and epiblast-specific conditional KO mice; cyclin E accumulation in null embryos; p21 double-knockdown rescue of extra-embryonic cell cycle arrest

    PMID:22453236 PMID:22606329

    Open questions at the time
    • Contribution of individual substrates to embryonic lethality not dissected
    • Brain isoform-specific neddylation regulation requires independent confirmation
  4. 2013 High

    The substrate repertoire expanded to include TSC2, Jab1/CSN5, and replication licensing factors, connecting CUL4B to mTOR activation in neurons, BMP signaling regulation, and DNA replication origin licensing via miR-372/373-CDK2-CDC6 cascade.

    Evidence In vitro ubiquitination assays, patient mutant expression in primary neocortical neurons, MEFs from Cul4b-null mice, miRNA epistasis and chromatin fractionation

    PMID:23348097 PMID:23357576 PMID:23479742

    Open questions at the time
    • DCAF adaptors for TSC2 and Jab1 not identified
    • Whether mTOR dysregulation is the primary driver of XLID neuronal phenotype unclear
  5. 2014 High

    CUL4B was shown to directly ubiquitinate and degrade p53, positioning CUL4B as a suppressor of the p53-ROS positive feedback loop that drives cellular senescence.

    Evidence CUL4B depletion and ectopic expression in normal human fibroblasts, p53 ubiquitination assay, ROS quantification, senescence assays

    PMID:24464738

    Open questions at the time
    • Whether CUL4B targets p53 directly or through MDM2 cooperativity not fully resolved
    • DCAF adaptor for p53 not identified
  6. 2015 High

    The epigenetic arm of CRL4B function was established: CUL4B catalyzes H2AK119 monoubiquitination and coordinates with PRC2-mediated H3K27me3 to silence Wnt antagonists, Ptgds, and PP2A phosphatases, linking CRL4B to Wnt/β-catenin activation, neural progenitor fate, AKT signaling, and MDSC control.

    Evidence ChIP for H2AK119ub and H3K27me3 at target promoters, nervous-system-specific and hematopoietic-specific Cul4b KO mice, PPP2R2B/Ptgds epistasis rescue

    PMID:25430888 PMID:26025376 PMID:26450912

    Open questions at the time
    • How CRL4B recruits PRC2 mechanistically not determined
    • Whether H2AK119ub1 is catalyzed by a CUL4B-associated RING1B or a distinct mechanism not resolved
  7. 2015 High

    CUL4B was shown to protect cells from DNA-damage-induced apoptosis by ubiquitinating HUWE1, thereby stabilizing the anti-apoptotic protein MCL-1.

    Evidence In vitro ubiquitination of HUWE1, CUL4B/HUWE1 double depletion epistasis, DNA damage sensitivity assays

    PMID:25883150

    Open questions at the time
    • DCAF adaptor mediating HUWE1 recognition unknown
    • Whether this pathway is relevant in vivo during genotoxic therapy not tested
  8. 2016 High

    Tissue-specific substrate targeting was demonstrated: CRL4B degrades PPARγ to restrain adipogenesis and INSL6 in germ cells, with conditional KO mice showing obesity/insulin sensitivity and male infertility phenotypes respectively.

    Evidence In vitro PPARγ and INSL6 ubiquitination assays, adipocyte-specific and germ-cell-specific Cul4b conditional KO mice with metabolic and fertility phenotyping

    PMID:26846852 PMID:27899484

    Open questions at the time
    • DCAF adaptors for PPARγ and INSL6 not identified
    • How CUL4B selects tissue-specific substrates mechanistically unclear
  9. 2017 High

    A double-negative feedback loop was identified: CRL4B epigenetically silences miR-194 via H2AK119ub1/H3K27me3, while miR-194 targets CUL4B's 3′-UTR; p53 activates miR-194 to negatively regulate CUL4B, forming a p53–miR-194–CUL4B circuit.

    Evidence ChIP for dual histone marks, miR-194 3′-UTR luciferase reporter, p53 epistasis, xenograft validation

    PMID:28164432

    Open questions at the time
    • How the feedback loop is set to different steady states in normal versus cancer cells not modeled
    • Whether other miRNAs participate in analogous loops unknown
  10. 2019 High

    CUL4B's role in innate immunity was established: CRL4B epigenetically represses PTEN in macrophages to sustain AKT-GSK3β anti-inflammatory signaling; its loss causes hyper-inflammatory TLR responses, and in myeloid cells CUL4B-deficient MDSCs produce elevated IL-6 driving tumor stemness.

    Evidence Myeloid-specific Cul4b KO mice challenged with LPS/polyI:C/Salmonella, ChIP at Pten promoter, GSK3β inhibitor rescue, IL-6 blocking and STAT3 inhibition rescue

    PMID:31235785 PMID:31729464

    Open questions at the time
    • Whether CUL4B's immune role is entirely epigenetic or also involves direct substrate degradation in macrophages not fully delineated
  11. 2019 High

    The requirement for DDB1–CUL4B interaction was pharmacologically validated: the small molecule TSC01682 specifically disrupts CUL4B–DDB1 binding and reduces p21 and PTEN ubiquitination, confirming DDB1 as an obligate adaptor for CRL4B substrate processing.

    Evidence Yeast-based HTS, co-IP disruption assay, substrate ubiquitination readout, in vivo tumor growth inhibition

    PMID:31598391

    Open questions at the time
    • Selectivity of TSC01682 for CUL4B over CUL4A not fully established
    • No structural data for the drug–protein interface
  12. 2021 High

    CRL4B was shown to interact with multiple HDAC-containing corepressor complexes (NuRD, SIN3A, CoREST, NcoR/SMRT) and to cooperate with transcription factors Snail and ZEB2 to repress E-cadherin and AXIN2 during EMT, revealing CRL4B as a multivalent chromatin-modifying scaffold.

    Evidence Reciprocal co-IPs, ChIP at CDH1 and AXIN2 promoters, EMT invasion assays, in vivo breast cancer models

    PMID:34026424

    Open questions at the time
    • Stoichiometry and exclusivity of CRL4B–corepressor interactions not determined
    • Whether CRL4B catalytic activity or scaffold function drives EMT not separated
  13. 2021 High

    CUL4B's role in adaptive immunity was defined: TCR stimulation activates CUL4B neddylation; Cul4b-deficient CD4+ T cells accumulate DNA damage with absent SMC1A phosphorylation, while c-Myc was later shown to upregulate CUL4B in CD8+ T cells to prevent replication stress during clonal expansion.

    Evidence T cell-specific Cul4b conditional KO, mass spectrometry interactome, phospho-SMC1A immunoblot, LCMV infection challenge

    PMID:33524014 PMID:37925424

    Open questions at the time
    • Direct CUL4B substrates mediating DNA damage repair in T cells not identified
    • Whether CUL4B functions in DNA repair via DCAF1 or an independent DCAF not resolved
  14. 2021 High

    CUL4B cooperates with TiPARP to degrade the aryl hydrocarbon receptor after ligand activation, placing CRL4B in xenobiotic receptor turnover.

    Evidence Cul4b-null MEFs, TiPARP double knockdown, AHR protein stability and transcriptional reporter assays

    PMID:34146543

    Open questions at the time
    • DCAF adaptor linking CRL4B to AHR not identified
    • Physiological relevance of CUL4B-dependent AHR degradation in toxicology not tested in vivo
  15. 2023 High

    The N-terminal extension's mitotic function was decoded: heavy phosphorylation during mitosis recruits two novel CUL4B-specific DCAFs (LIS1 and WDR1 via DDB1) and triggers chromatin exclusion; this is required for spindle positioning and cortical tension, and the XLID-causing P50L mutation perturbs this phosphorylation.

    Evidence Phosphoproteomics, co-IP of LIS1/WDR1 with DDB1, phosphosite mutagenesis, live-cell imaging, cortical tension measurements, human forebrain organoid model

    PMID:37365982

    Open questions at the time
    • Substrates of the LIS1/WDR1-recruited CRL4B complex during mitosis not identified
    • Structural basis of phospho-NTE–DCAF interaction not resolved
  16. 2023 High

    Additional degradation substrates UTX (via COP1 adaptor) and MEN1 (via DCAF7 adaptor) were identified, expanding the catalog of DCAF-specific substrate recognition modules for CRL4B in colorectal and pancreatic neuroendocrine tumor contexts.

    Evidence Co-IPs, ubiquitination assays, conditional Cop1 KO with UTX accumulation, DCAF7/MEN1 double knockdown epistasis, xenograft models

    PMID:36939378 PMID:37679762

    Open questions at the time
    • Whether CUL4B versus CUL4A is selectively engaged by COP1 and DCAF7 not tested
    • Crystal structure of CRL4B–COP1–UTX or CRL4B–DCAF7–MEN1 complexes unavailable
  17. 2024 High

    The XLID neurogenesis mechanism was connected to PP2A: CUL4B mutations derepress PPP2R2B and PPP2R2C via loss of H2AK119ub at their promoters, causing elevated PP2A activity, AKT/ERK inhibition, premature cell cycle exit, and precocious neuronal differentiation in patient-derived cortical organoids.

    Evidence Patient iPSC-derived cerebral organoids, ChIP for H2AK119ub at PP2A subunit promoters, PP2A activity assay, pharmacological AKT/ERK activation and PP2A inhibition rescue

    PMID:38331954

    Open questions at the time
    • Whether PP2A derepression is the sole driver of XLID phenotype versus contributions from cyclin E, TSC2, or spindle defects not resolved
    • Long-term cognitive correlates of organoid findings not established
  18. 2024 High

    CUL4B was shown to protect kidneys from acute injury through context-dependent regulation: before damage it stabilizes PSME3 to suppress p53, while after radiation it dissociates from PSME3 and translocates to γH2AX foci to inhibit BRCA1/RAD51 and promote apoptosis of damaged cells.

    Evidence Kidney-specific Cul4b KO mice under cisplatin and IR stress, co-IP and ubiquitination assays for PSME3, p53/PAI-1 inhibitor rescue

    PMID:39695153

    Open questions at the time
    • How CUL4B senses DNA damage to trigger PSME3 dissociation is mechanistically undefined
    • Whether this dual role occurs in other tissues not tested

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include: how CRL4B selects between its epigenetic (H2AK119ub) and proteolytic (polyubiquitination) activities at specific loci; the structural basis of the phosphorylated N-terminal extension's DCAF-switching during mitosis; and whether the diverse tissue-specific phenotypes of CUL4B loss converge on a shared molecular bottleneck or reflect genuinely independent substrate circuits.
  • No structural model of CRL4B holoenzyme with N-terminal extension
  • Mechanism of monoubiquitin versus polyubiquitin chain-type specification by CRL4B unknown
  • Systematic identification of all DCAFs specific to CUL4B versus CUL4A not completed

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 15 GO:0140110 transcription regulator activity 10 GO:0016874 ligase activity 6
Localization
GO:0005634 nucleus 3 GO:0005694 chromosome 3 GO:0005829 cytosol 2
Pathway
R-HSA-392499 Metabolism of proteins 15 R-HSA-4839726 Chromatin organization 11 R-HSA-1640170 Cell Cycle 7 R-HSA-162582 Signal Transduction 6 R-HSA-1266738 Developmental Biology 5 R-HSA-168256 Immune System 4 R-HSA-73894 DNA Repair 4 R-HSA-74160 Gene expression (Transcription) 4
Partners
COP1DCAF1DCAF7DDB1EZH2LIS1ROC1WDR1
Complex memberships
CRL4B (CUL4B-DDB1-ROC1)CRL4B-PRC2

Evidence

Reading pass · 39 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2009 CUL4B contains a unique N-terminal nuclear localization signal (NLS) at amino acids 37-40 (KKRK) that binds importin α1, α3, and α5; this NLS is required for nuclear entry and for CUL4B-mediated ubiquitination and degradation of cyclin E, enabling cell cycle progression. NLS-deleted CUL4B localizes to the cytoplasm and fails to promote cell proliferation. RNAi knockdown, NLS deletion mutagenesis, importin binding assays, cyclin E ubiquitination assays, cell proliferation assays The Journal of biological chemistry High 19801544
2007 CUL4B encodes the scaffold protein of a cullin-RING ubiquitin E3 ligase (CRL4B) complex; truncating and missense mutations abolish its C-terminal catalytic domain and cause nonsense-mediated mRNA decay, establishing CUL4B as a ubiquitin E3 ligase subunit required for cognition and development. Genetic mutation identification, functional domain analysis, NMD demonstration in patient leukocytes American journal of human genetics High 17236139 17273978
2012 In Cul4b-null mouse embryos, cyclin E (a CRL4B substrate) accumulates, confirming that CUL4B is required for cyclin E ubiquitination in vivo; Cul4b null embryos die by E9.5 with severe developmental arrest. Cul4b knockout mouse generation (exons 3-5 deletion), Western blot for cyclin E accumulation in null embryos PloS one High 22606329
2012 CUL4B loss in extra-embryonic tissues leads to robust accumulation of p21(Cip1/WAF) and G2/M cell cycle arrest; p21 silencing partially rescues this arrest, placing p21 as a direct CUL4B substrate in extra-embryonic cells. Epiblast-specific Cul4b conditional knockout, extra-embryonic cell line CUL4B silencing, p21 double knockdown rescue epistasis Cell research High 22453236
2013 CUL4B promotes replication licensing by positively regulating CDC6 via CDK2: CUL4B represses miR-372 and miR-373 to upregulate CDK2, which phosphorylates CDC6, protecting it from APC(CDH1)-mediated degradation and allowing MCM2 loading onto chromatin. CUL4B knockdown, miRNA manipulation, CDK2/CDC6 epistasis, chromatin fractionation for MCM2, CDC6 phosphorylation assays The Journal of cell biology High 23479742
2013 CUL4B ubiquitin ligase complex (requiring DDB1-CUL4B-ROC1 integrity) targets Jab1/CSN5 for polyubiquitination and proteasomal degradation; loss of CUL4B leads to Jab1 accumulation and abnormal upregulation of BMP signaling in vitro and in Cul4b-deficient mouse embryonic fibroblasts. RNAi depletion, co-immunoprecipitation, in vitro and in vivo ubiquitination assays, MEF analysis from Cul4b-null mice Biochimica et biophysica acta High 23357576
2013 XLID-associated CUL4B mutants (R388X, R572C, V745A) are defective in promoting ubiquitination and degradation of TSC2 and cyclin E in neurons; by promoting TSC2 degradation, wild-type CUL4B positively regulates mTOR activity (phospho-mTOR, phospho-p70S6K, phospho-4E-BP1) in neocortical neurons. Adenovirus-mediated expression of WT and mutant CUL4B in neocortical neurons, shRNA knockdown, Western blot for TSC2/cyclin E/mTOR pathway components Biochimica et biophysica acta High 23348097
2014 CUL4B negatively regulates the p53-ROS positive feedback loop driving cellular senescence: CUL4B promotes p53 ubiquitination and proteasomal degradation in human fibroblasts under oxidative stress, and its loss amplifies p53-dependent ROS production and senescence. CUL4B depletion and ectopic expression in NHFs, p53 ubiquitination assay, ROS measurement, senescence assay Free radical biology & medicine High 25464270
2015 CUL4B activates Wnt/β-catenin signaling in hepatocellular carcinoma by epigenetically silencing Wnt antagonists (DKK1, PPP2R2B): CRL4B promotes PRC2 recruitment and H3K27me3 at antagonist promoters; knockdown of PPP2R2B partially reverses CUL4B-depletion-induced β-catenin downregulation. CUL4B knockdown/overexpression, ChIP for PRC2 and H3K27me3, PPP2R2B double knockdown rescue epistasis, in vitro and xenograft assays The Journal of pathology High 25430888
2015 CUL4B is activated by DNA damage in a NEDD8-dependent manner and ubiquitinates HUWE1 in vitro and in vivo, targeting it for proteasomal degradation; CUL4B depletion stabilizes HUWE1, accelerating MCL-1 degradation and increasing apoptosis sensitivity to DNA damage reagents, an effect rescued by simultaneous HUWE1 depletion. In vitro ubiquitination assay, CUL4B knockdown, HUWE1/CUL4B double depletion epistasis, DNA damage reagent sensitivity assays Nucleic acids research High 25883150
2015 CUL4B represses GFAP expression in neural progenitor cells by targeting and epigenetically repressing Ptgds (encoding PTGDS) via the CUL4B/PRC2 complex; PTGDS inhibition or knockdown attenuates increased GFAP+ cell generation caused by Cul4b loss. Nervous-system-specific Cul4b KO mouse, NPC cultures, shRNA knockdown of Ptgds, pharmacological PTGDS inhibition rescue Human molecular genetics High 26025376
2016 CRL4B negatively regulates PPARγ stability by promoting its polyubiquitination and proteasomal degradation; adipocyte-specific Cul4b KO mice show upregulated PPARγ-target genes, increased adipogenesis, improved insulin sensitivity, and decreased adipose inflammation. In vitro PPARγ ubiquitination assay, adipocyte-specific Cul4b conditional KO mice, high-fat diet metabolic phenotyping Diabetes High 27899484
2016 Germ cell-specific deletion of Cul4b causes male infertility due to impaired sperm motility associated with reduced mitochondrial activity, glycolysis, and ATP production, defective axonemal microtubule and flagella outer dense fiber arrangement. INSL6 was identified as a novel CUL4B substrate in male germ cells by direct polyubiquitination and degradation assays. Cul4b conditional KO (Vasa-Cre), mass spectrometry substrate identification, in vitro polyubiquitination of INSL6, sperm motility/ATP assays The Journal of biological chemistry High 26846852
2019 CUL4B promotes macrophage migration and adhesion by epigenetically repressing miR-194-5p, leading to elevated integrin α9 (ITGA9); high glucose upregulates CUL4B in macrophages, and myeloid CUL4B deficiency suppresses macrophage renal infiltration and alleviates diabetic kidney injury. Myeloid-specific Cul4b KO mouse DKD models, ChIP for H2AK119ub at miR-194-5p locus, ITGA9 validation, macrophage migration/adhesion assays Cell reports High 37224018
2019 CUL4B epigenetically represses Pten transcription in macrophages (maintaining AKT-GSK3β anti-inflammatory pathway); CUL4B deletion leads to PTEN upregulation, uncontrolled GSK3β activity and excessive TLR-triggered inflammatory cytokine production; GSK3β inhibition rescues the phenotype. Myeloid-specific Cul4b KO mice, LPS/polyI:C/Salmonella challenge, ChIP at Pten promoter, GSK3β inhibitor rescue, cytokine measurements Cellular & molecular immunology High 31729464
2021 CUL4B interacts with HBx protein and inhibits its ubiquitin-dependent proteasomal degradation, stabilizing HBx and promoting HBV replication; CUL4B promotes HBV replication in an HBx-dependent manner confirmed in transgenic and conditional KO mouse hepatitis B models. Co-immunoprecipitation, immunofluorescence co-localization, cycloheximide chase assay, in vivo ubiquitination assay, Cul4b transgenic and conditional KO mice with hydrodynamics-based HBV model Cancer biology & medicine High 33969670
2021 CRL4B interacts with multiple HDAC-containing corepressor complexes (MTA1/NuRD, SIN3A, CoREST, NcoR/SMRT) and co-occupies E-cadherin and AXIN2 promoters together with transcription factors Snail and ZEB2 to repress their transcription and promote breast cancer EMT. Co-immunoprecipitation, ChIP, functional assays (invasion, EMT), in vitro and in vivo tumor models Advanced science (Weinheim, Baden-Wurttemberg, Germany) High 34026424
2021 CUL4B loss partially prevents TCDD-activated AHR proteasomal degradation; TiPARP knockdown in CUL4B-null cells completely abolishes AHR degradation, revealing that CUL4B (E3 ubiquitin ligase targeting AHR for ubiquitination) and TiPARP (ADP-ribosylation) cooperate to promote AHR nuclear export and degradation after TCDD activation. Cul4b-null MEF cell line, TiPARP siRNA knockdown, AHR protein stability assays, AHR transcriptional activity reporter The Journal of biological chemistry High 34146543
2021 THAP7-AS1 lncRNA interacts with the 1-50 aa NLS region of CUL4B and promotes interaction between NLS and importin α1, enhancing CUL4B nuclear entry; nuclear CUL4B then represses miR-22-3p and miR-320a via H2AK119ub1 and EZH2-mediated H3K27me3, activating PI3K/AKT signaling. RNA pulldown, co-immunoprecipitation, domain mapping (NLS deletion), fractionation, ChIP, miRNA quantification Cell death and differentiation High 34608273
2021 Cul4b abundance and neddylation increase after TCR stimulation; Cul4b-deficient CD4+ T cells show impaired proliferation, survival, and accumulated DNA damage; Cul4b preferentially associates with DCAF1 and interacts with DNA damage sensing/repair proteins; downstream SMC1A phosphorylation is absent in Cul4b-KO T cells despite DNA damage sensing. T cell conditional KO, proliferation and survival assays, mass spectrometry interactome, phospho-SMC1A immunoblot PLoS biology High 33524014
2023 CUL4B N-terminal extension is heavily phosphorylated during mitosis; this phosphorylation promotes binding to two novel CUL4B-specific DCAFs (LIS1 and WDR1, which interact with DDB1) while triggering chromatin exclusion and binding to actin regulators; phosphorylation is required for mitotic spindle positioning and cortical tension control. The XLID-causing P50L mutation perturbs this phosphorylation pattern. Phosphoproteomics, co-immunoprecipitation of LIS1/WDR1 with DDB1, mutagenesis of phosphorylation sites, live-cell imaging, cortical tension measurements, human forebrain organoid model The EMBO journal High 37365982
2023 CUL4B-DDB1-COP1 complex functions as the E3 ligase responsible for UTX (KDM6A) ubiquitination and proteasomal degradation in colorectal cancer cells; Cop1 deficiency in mouse intestinal tissue results in UTX accumulation. Co-immunoprecipitation, immunoblot, conditional Cop1 KO mouse, GSK126 (EZH2 inhibitor) rescue Experimental hematology & oncology High 37679762
2023 CUL4B and DCAF7 promote MEN1 ubiquitination and proteasomal degradation in pancreatic neuroendocrine tumor cells; suppression of DCAF7 or neddylation (with MLN4924) induces MEN1 accumulation; simultaneous MEN1 knockdown counteracts DCAF7 loss effects. Co-immunoprecipitation, ubiquitination assays, MLN4924 neddylation inhibition, DCAF7/MEN1 double knockdown epistasis, in vivo xenograft Cancer research High 36939378
2023 c-Myc increases CUL4B levels in activated CD8+ T cells; Cul4b-deficient CD8+ T cells accumulate DNA damage and undergo proliferative catastrophe with p21 and Cyclin E2 accumulation (replication stress), failing to clear LCMV in vivo; this places CUL4B downstream of c-Myc in maintaining genome stability during T cell expansion. T cell-specific Cul4b KO, in vivo LCMV challenge, DNA damage markers, p21/CyclinE2 Western blot, proliferation assays Nature communications High 37925424
2023 CUL4B directly binds the Cxcl2 promoter and epigenetically represses its transcription; CUL4B deletion increases CXCL2, which binds CXCR2 on MDSCs promoting their tumor infiltration and lung ADC progression. CUL4B KO autochthonous and transplantable KRAS-mutant models, ChIP at Cxcl2 promoter, CXCL2/CXCR2 functional assays, MDSC targeting rescue Oncogene High 37653114
2023 CUL4B promotes MEN1 osteogenic differentiation of mesenchymal stem cells by epigenetically repressing KLF4 (inhibiting adipogenesis) and C/EBPδ (promoting osteogenesis); CRL4B complex directly binds Klf4 and Cebpd promoters to repress their transcription. MSC-specific Cul4b conditional KO mice, ChIP at Klf4 and Cebpd promoters, osteogenesis/adipogenesis differentiation assays, aging and ovariectomy models Bone research High 37268647
2024 CRL4B represses transcription of PPP2R2B and PPP2R2C (PP2A regulatory subunit isoforms) by catalyzing H2AK119 monoubiquitination at their promoters; CUL4B mutations cause upregulated PP2A activity, which inhibits AKT and ERK, leading to premature cell cycle exit and precocious neuronal differentiation in cortical organoids; AKT/ERK activation or PP2A inhibition rescues the neurogenesis defect. Patient iPSC-derived cerebral organoids and 2D neuronal cultures, ChIP for H2AK119ub at PP2A regulatory subunit promoters, PP2A activity assay, AKT/ERK phosphorylation, pharmacological rescue Cell death & disease High 38331954
2024 CUL4B protects kidneys from acute injury by promoting polyubiquitination and degradation of p53, suppressing PAI-1 expression; prior to radiation, CUL4B inhibits ubiquitination of PSME3 (causing its accumulation and negative regulation of p53-mediated apoptosis), whereas after radiation, CUL4B dissociates from PSME3 and translocates to γH2AX foci, inhibiting BRCA1 phosphorylation and RAD51 to augment apoptosis. Kidney-specific Cul4b KO mice (cisplatin and IR models), transcriptome analysis, p53 ubiquitination assay, PSME3 co-IP and ubiquitination, p53/PAI-1 inhibitor rescue Cell death & disease High 39695153
2015 CUL4B/AKT/β-catenin axis in hematopoietic cells restricts MDSC accumulation; hematopoietic-specific Cul4b ablation (Tek-Cre) causes aberrant MDSC expansion mediated by downregulation of AKT/β-catenin; CUL4B epigenetically represses PP2A and PHLPP1/2 phosphatases to sustain AKT activation. Hematopoietic-specific Cul4b conditional KO (Tek-Cre), MDSC quantification by flow cytometry, AKT/β-catenin pathway analysis, PP2A/PHLPP1/2 expression analysis Cancer research High 26450912
2019 CUL4B-deficient MDSCs produce elevated IL-6, which activates IL-6/STAT3 signaling in tumor cells to confer stem cell-like properties; the CRL4B complex epigenetically represses IL-6 transcription in myeloid cells via histone modification. Hematopoietic and myeloid-specific Cul4b KO mice, IL-6 ELISA, STAT3 phosphorylation, IL-6 blocking and STAT3 inhibition rescue, tumor transplantation models Oncogene High 31235785
2017 CRL4B complex epigenetically represses miR-194 by catalyzing H2AK119 monoubiquitination and coordinating with PRC2 for H3K27 trimethylation at the miR-194 gene cluster; miR-194 directly targets CUL4B 3'-UTR to downregulate it; p53 negatively regulates CUL4B via miR-194, forming a double-negative feedback loop. ChIP for H2AK119ub and H3K27me3, miR-194 overexpression/inhibition, 3'-UTR luciferase reporter, p53 epistasis Molecular oncology High 28164432
2020 CRL4B epigenetically represses miR-372/373 transcription by catalyzing H2AK119 monoubiquitination at their gene cluster, leading to upregulation of PIK3CA and AKT activation in bladder cancer; this establishes the CUL4B-miR-372/373-PIK3CA/AKT axis in bladder cancer pathogenesis. ChIP for H2AK119ub at miR-372/373 locus, miR-372/373 overexpression/inhibition, PIK3CA/AKT pathway analysis, xenograft model Oncogene High 32127645
2019 Small molecule TSC01682 specifically disrupts the CUL4B-DDB1 interaction (identified by HTS in yeast), decreasing assembly of CRL4B and reducing ubiquitination of substrates CDKN1A (p21) and PTEN in osteosarcoma cells, demonstrating that direct CUL4B-DDB1 binding is required for CRL4B complex assembly and substrate ubiquitination. In vitro yeast-based HTS, co-immunoprecipitation of CUL4B-DDB1 in yeast and human cells, p21/PTEN ubiquitination assay, in vivo tumor growth inhibition American journal of cancer research High 31598391
2015 CUL4B variants in XLID patients interact with WDR62 (a microcephaly protein); this interaction was demonstrated by co-immunoprecipitation and may contribute to cerebral malformations. Co-immunoprecipitation of CUL4B with WDR62, genetic patient cohort analysis Human mutation Medium 25385192
2012 Three major CUL4B isoforms exist in brain: Cul4B-1 and -2 are predominantly unneddylated (due to their N-terminus inhibiting neddylation), while the smaller Cul4B-3 lacking the N-terminus is neddylated; knockdown of Cul4b arrests neural progenitor cells in G2/M phase; unneddylated Cul4B promotes β-catenin accumulation during mitosis. Endogenous isoform characterization, neddylation immunoblot, shRNA-mediated knockdown, cell cycle analysis, immunostaining in brain tissues BMC neuroscience Medium 22992378
2025 CUL4B promotes ubiquitination and degradation of ARID1A within the SWI/SNF complex in thyroid cancer; CUL4B-mediated ARID1A degradation decreases expression of the differentiation marker PAX8, driving dedifferentiation toward anaplastic thyroid carcinoma. CUL4B overexpression/knockdown in vivo models, RNA-seq, ubiquitination assays for ARID1A, co-immunoprecipitation, PAX8 immunohistochemistry Translational oncology Medium 40203790
2023 CUL4B promotes G-CSF (Csf3) expression in colorectal cancer epithelial cells by epigenetically repressing Csf3 transcription in a PRC2-dependent manner; CUL4B deletion activates G-CSF, promoting MDSC recruitment to ApcMin/+ adenomas. ApcMin/+;Cul4bΔIEC mouse model, ChIP for PRC2 at Csf3 promoter, MDSC quantification, in vivo MDSC inhibition, organoid assays Neoplasia (New York, N.Y.) Medium 38761506
2021 CUL4B coordinates with HDAC to co-occupy the CDKN1A (p21) promoter and epigenetically silence CDKN1A transcription in glioblastoma, leading to attenuation of TMZ-induced senescence and TMZ resistance; CUL4B knockdown restores TMZ sensitivity. ChIP for CUL4B and HDAC at CDKN1A promoter, senescence β-galactosidase staining, CUL4B knockdown TMZ sensitivity assays Frontiers in oncology Medium 33869025
2020 CREB acts as a transcription factor for CUL4B by directly binding CREs in the CUL4B promoter; ChIP confirmed pCREB occupancy at CUL4B promoter, and CREB overexpression increases CUL4B expression along with H3K27me3 and H2AK119ub marks. Site-directed mutagenesis of CRE sites, promoter reporter assay, ChIP for pCREB at CUL4B promoter, CREB overexpression/knockdown Medical oncology (Northwood, London, England) Medium 32710193

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2007 Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor. American journal of human genetics 192 17236139
2021 lncRNA THAP7-AS1, transcriptionally activated by SP1 and post-transcriptionally stabilized by METTL3-mediated m6A modification, exerts oncogenic properties by improving CUL4B entry into the nucleus. Cell death and differentiation 161 34608273
2007 Mutation in CUL4B, which encodes a member of cullin-RING ubiquitin ligase complex, causes X-linked mental retardation. American journal of human genetics 135 17273978
2009 Characterization of nuclear localization signal in the N terminus of CUL4B and its essential role in cyclin E degradation and cell cycle progression. The Journal of biological chemistry 104 19801544
2015 Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B. Gene 99 26344709
2012 Lack of Cul4b, an E3 ubiquitin ligase component, leads to embryonic lethality and abnormal placental development. PloS one 70 22606329
2015 CUL4B activates Wnt/β-catenin signalling in hepatocellular carcinoma by repressing Wnt antagonists. The Journal of pathology 65 25430888
2012 Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis. Cell research 60 22453236
2019 Circular RNA ZFR accelerates non-small cell lung cancer progression by acting as a miR-101-3p sponge to enhance CUL4B expression. Artificial cells, nanomedicine, and biotechnology 57 31407591
2015 The CUL4B/AKT/β-Catenin Axis Restricts the Accumulation of Myeloid-Derived Suppressor Cells to Prohibit the Establishment of a Tumor-Permissive Microenvironment. Cancer research 51 26450912
2012 Rescue of the genetically engineered Cul4b mutant mouse as a potential model for human X-linked mental retardation. Human molecular genetics 50 22763239
2009 A novel nonsense mutation in CUL4B gene in three brothers with X-linked mental retardation syndrome. Clinical genetics 49 20002452
2016 Lack of CUL4B in Adipocytes Promotes PPARγ-Mediated Adipose Tissue Expansion and Insulin Sensitivity. Diabetes 46 27899484
2010 Deletion of the CUL4B gene in a boy with mental retardation, minor facial anomalies, short stature, hypogonadism, and ataxia. American journal of medical genetics. Part A 43 20014135
2019 Inflammation-dependent downregulation of miR-194-5p contributes to human intervertebral disc degeneration by targeting CUL4A and CUL4B. Journal of cellular physiology 41 30945295
2017 CUL4B promotes gastric cancer invasion and metastasis-involvement of upregulation of HER2. Oncogene 39 29106389
2015 Variants in CUL4B are associated with cerebral malformations. Human mutation 39 25385192
2017 MicroRNA-300 promotes apoptosis and inhibits proliferation, migration, invasion and epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway by targeting CUL4B in pancreatic cancer cells. Journal of cellular biochemistry 37 28685847
2011 CUL4B-deficiency in humans: understanding the clinical consequences of impaired Cullin 4-RING E3 ubiquitin ligase function. Mechanisms of ageing and development 37 21352845
2019 NCBP1 promotes the development of lung adenocarcinoma through up-regulation of CUL4B. Journal of cellular and molecular medicine 36 31448526
2017 Dysregulation of the miR-194-CUL4B negative feedback loop drives tumorigenesis in non-small-cell lung carcinoma. Molecular oncology 36 28164432
2016 Dysregulation of CUL4A and CUL4B Ubiquitin Ligases in Lung Cancer. The Journal of biological chemistry 36 27974468
2023 MEN1 Degradation Induced by Neddylation and the CUL4B-DCAF7 Axis Promotes Pancreatic Neuroendocrine Tumor Progression. Cancer research 35 36939378
2021 The Traditional Chinese Medicine Compound Huangqin Qingre Chubi Capsule Inhibits the Pathogenesis of Rheumatoid Arthritis Through the CUL4B/Wnt Pathway. Frontiers in pharmacology 34 34512369
2016 Cell Autonomous and Nonautonomous Function of CUL4B in Mouse Spermatogenesis. The Journal of biological chemistry 34 26846852
2020 The CUL4B-miR-372/373-PIK3CA-AKT axis regulates metastasis in bladder cancer. Oncogene 32 32127645
2015 DNA damage-induced activation of CUL4B targets HUWE1 for proteasomal degradation. Nucleic acids research 32 25883150
2021 Roles of the ubiquitin ligase CUL4B and ADP-ribosyltransferase TiPARP in TCDD-induced nuclear export and proteasomal degradation of the transcription factor AHR. The Journal of biological chemistry 30 34146543
2013 CUL4B promotes replication licensing by up-regulating the CDK2-CDC6 cascade. The Journal of cell biology 30 23479742
2020 Downregulation of lncRNA ZEB1-AS1 Represses Cell Proliferation, Migration, and Invasion Through Mediating PI3K/AKT/mTOR Signaling by miR-342-3p/CUL4B Axis in Prostate Cancer. Cancer biotherapy & radiopharmaceuticals 29 32275162
2014 CUL4B promotes proliferation and inhibits apoptosis of human osteosarcoma cells. Oncology reports 29 25189186
2019 CUL4B/miR-33b/C-MYC axis promotes prostate cancer progression. The Prostate 28 30609075
2018 miR‑381 and miR‑489 suppress cell proliferation and invasion by targeting CUL4B via the Wnt/β‑catenin pathway in gastric cancer. International journal of oncology 28 30483755
2016 Human X-linked Intellectual Disability Factor CUL4B Is Required for Post-meiotic Sperm Development and Male Fertility. Scientific reports 28 26832838
2020 Cul4B promotes the progression of ovarian cancer by upregulating the expression of CDK2 and CyclinD1. Journal of ovarian research 27 32622365
2017 CUL4B promotes bladder cancer metastasis and induces epithelial-to-mesenchymal transition by activating the Wnt/β-catenin signaling pathway. Oncotarget 27 29100384
2016 Knockdown of CUL4B Suppresses the Proliferation and Invasion in Non-Small Cell Lung Cancer Cells. Oncology research 27 27656838
2021 CUL4B renders breast cancer cells tamoxifen-resistant via miR-32-5p/ER-α36 axis. The Journal of pathology 26 33638154
2020 Circ_0015756 promotes the progression of ovarian cancer by regulating miR-942-5p/CUL4B pathway. Cancer cell international 26 33292255
2019 CUL4B promotes prostate cancer progression by forming positive feedback loop with SOX4. Oncogenesis 26 30872583
2019 Upregulation of IL-6 in CUL4B-deficient myeloid-derived suppressive cells increases the aggressiveness of cancer cells. Oncogene 26 31235785
2023 CUL4B-DDB1-COP1-mediated UTX downregulation promotes colorectal cancer progression. Experimental hematology & oncology 25 37679762
2021 CUL4B Promotes Breast Carcinogenesis by Coordinating with Transcriptional Repressor Complexes in Response to Hypoxia Signaling Pathway. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 25 34026424
2014 CUL4B impedes stress-induced cellular senescence by dampening a p53-reactive oxygen species positive feedback loop. Free radical biology & medicine 25 25464270
2020 CUL4B contributes to cancer stemness by repressing tumor suppressor miR34a in colorectal cancer. Oncogenesis 23 32054830
2018 CUL4B promotes the pathology of adjuvant-induced arthritis in rats through the canonical Wnt signaling. Journal of molecular medicine (Berlin, Germany) 23 29626254
2023 Depletion of CUL4B in macrophages ameliorates diabetic kidney disease via miR-194-5p/ITGA9 axis. Cell reports 21 37224018
2019 CUL4B negatively regulates Toll-like receptor-triggered proinflammatory responses by repressing Pten transcription. Cellular & molecular immunology 21 31729464
2019 CUL4B regulates autophagy via JNK signaling in diffuse large B-cell lymphoma. Cell cycle (Georgetown, Tex.) 20 30612524
2018 CUL4B promotes metastasis and proliferation in pancreatic cancer cells by inducing epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway. Journal of cellular biochemistry 20 29274277
2015 Lack of CUL4B leads to increased abundance of GFAP-positive cells that is mediated by PTGDS in mouse brain. Human molecular genetics 20 26025376
2013 X-linked intellectual disability gene CUL4B targets Jab1/CSN5 for degradation and regulates bone morphogenetic protein signaling. Biochimica et biophysica acta 20 23357576
2012 Cul4B regulates neural progenitor cell growth. BMC neuroscience 20 22992378
2021 The E3 ubiquitin ligase Cul4b promotes CD4+ T cell expansion by aiding the repair of damaged DNA. PLoS biology 19 33524014
2018 MiR-431 inhibits colorectal cancer cell invasion via repressing CUL4B. European review for medical and pharmacological sciences 19 29863249
2015 Decreased CUL4B expression inhibits malignant proliferation of glioma in vitro and in vivo. European review for medical and pharmacological sciences 19 25855927
2015 Knockdown of CUL4B inhibits proliferation and promotes apoptosis of colorectal cancer cells through suppressing the Wnt/β-catenin signaling pathway. International journal of clinical and experimental pathology 19 26617747
2020 Circ_0074027 Contributes to Non-Small Cell Lung Cancer Progression by Upregulating CUL4B Expression Through miR-335-5p. Cancer biotherapy & radiopharmaceuticals 18 32580576
2018 MiRNA-708/CUL4B axis contributes into cell proliferation and apoptosis of osteosarcoma. European review for medical and pharmacological sciences 17 30229816
2013 XLID CUL4B mutants are defective in promoting TSC2 degradation and positively regulating mTOR signaling in neocortical neurons. Biochimica et biophysica acta 16 23348097
2021 Inhibition of MicroRNA miR-101-3p on prostate cancer progression by regulating Cullin 4B (CUL4B) and PI3K/AKT/mTOR signaling pathways. Bioengineered 15 34338146
2023 The CUL4B-based E3 ubiquitin ligase regulates mitosis and brain development by recruiting phospho-specific DCAFs. The EMBO journal 14 37365982
2021 LncRNA SNHG12 regulates the miR-101-3p/CUL4B axis to mediate the proliferation, migration and invasion of non-small cell lung cancer. The Kaohsiung journal of medical sciences 14 34002487
2014 Donor splice-site mutation in CUL4B is likely cause of X-linked intellectual disability. American journal of medical genetics. Part A 14 24898194
2014 Zebrafish cul4a, but not cul4b, modulates cardiac and forelimb development by upregulating tbx5a expression. Human molecular genetics 14 25274780
2015 CUL4B: a novel epigenetic driver in Wnt/β-catenin-dependent hepatocarcinogenesis. The Journal of pathology 13 25664533
2024 CUL4B mutations impair human cortical neurogenesis through PP2A-dependent inhibition of AKT and ERK. Cell death & disease 11 38331954
2023 Knockdown of circMFN2 inhibits cell progression and glycolysis by miR-198/CUL4B pathway in ovarian cancer. Journal of biochemical and molecular toxicology 11 37158446
2023 CUL4B orchestrates mesenchymal stem cell commitment by epigenetically repressing KLF4 and C/EBPδ. Bone research 11 37268647
2020 CREB acts as a common transcription factor for major epigenetic repressors; DNMT3B, EZH2, CUL4B and E2F6. Medical oncology (Northwood, London, England) 11 32710193
2019 Small molecule TSC01682 inhibits osteosarcoma cell growth by specifically disrupting the CUL4B-DDB1 interaction and decreasing the ubiquitination of CRL4B E3 ligase substrates. American journal of cancer research 11 31598391
2019 Alu-mediated Xq24 deletion encompassing CUL4B, LAMP2, ATP1B4, TMEM255A, and ZBTB33 genes causes Danon disease in a female patient. American journal of medical genetics. Part A 11 31729179
2017 Genome-first approach diagnosed Cabezas syndrome via novel CUL4B mutation detection. Human genome variation 11 28144446
2022 LncRNA NEAT1 Targets miR-342-3p/CUL4B to Inhibit the Proliferation of Cutaneous Squamous Cell Carcinoma Cells. Journal of oncology 10 35909905
2019 CUL4B regulates cancer stem-like traits of prostate cancer cells by targeting BMI1 via miR200b/c. The Prostate 10 31111526
2023 CUL4B functions as a tumor suppressor in KRAS-driven lung tumors by inhibiting the recruitment of myeloid-derived suppressor cells. Oncogene 9 37653114
2022 Exosomal circKDM4A Induces CUL4B to Promote Prostate Cancer Cell Malignancy in a miR-338-3p-Dependent Manner. Biochemical genetics 9 35930171
2022 CUL4B increases platinum-based drug resistance in colorectal cancer through EMT: A study in its mechanism. Journal of cellular and molecular medicine 9 36385733
2022 CUL4B Upregulates RUNX2 to Promote the Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Epigenetically Repressing the Expression of miR-320c and miR-372/373-3p. Frontiers in cell and developmental biology 8 35784474
2020 Genome-first approach for the characterization of a complex phenotype with combined NBAS and CUL4B deficiency. Bone 8 32768688
2016 CUL4B, NEDD4, and UGT1As involve in the TGF-β signalling in hepatocellular carcinoma. Annals of hepatology 8 27236156
2023 c-Myc uses Cul4b to preserve genome integrity and promote antiviral CD8+ T cell immunity. Nature communications 7 37925424
2022 Lnc-TC/miR-142-5p/CUL4B signaling axis promoted cell ferroptosis to participate in benzene hematotoxicity. Life sciences 7 36272464
2022 CUL4B-associated epilepsy: Report of a novel truncating variant promoting drug-resistant seizures and systematic review of the literature. Seizure 7 36476360
2024 CUL4B protects kidneys from acute injury by restraining p53/PAI-1 signaling. Cell death & disease 6 39695153
2021 Effect and mechanism of miR-217 on drug resistance, invasion and metastasis of ovarian cancer cells through a regulatory axis of CUL4B gene silencing/inhibited Wnt/β-catenin signaling pathway activation. European review for medical and pharmacological sciences 6 33506897
2024 Circ_0011058 alleviates RA pathology through the circ_0011058/miR-335-5p/CUL4B signal axis. Autoimmunity 5 38254314
2024 Enhanced ApcMin/+ adenoma formation after epithelial CUL4B deletion by recruitment of myeloid-derived suppressor cells. Neoplasia (New York, N.Y.) 5 38761506
2021 CUL4B Promotes Temozolomide Resistance in Gliomas by Epigenetically Repressing CDNK1A Transcription. Frontiers in oncology 5 33869025
2021 CUL4B facilitates HBV replication by promoting HBx stabilization. Cancer biology & medicine 5 33969670
2019 CUL4B promotes aggressive phenotypes of HNSCC via the activation of the Wnt/β-catenin signaling pathway. Cancer medicine 5 30883036
2024 Dynamic role of CUL4B in radiation-induced intestinal injury-regeneration. Scientific reports 4 38689033
2023 CUL4B enhances the malignant phenotype of esophageal squamous cell carcinoma by suppressing TGFBR3 expression. Biochemical and biophysical research communications 4 37487438
2023 B cell expression of E3 ubiquitin ligase Cul4b promotes chronic gammaherpesvirus infection in vivo. Journal of virology 4 37962378
2023 Histone ubiquitination-related gene CUL4B promotes lung adenocarcinoma progression and cisplatin resistance. Frontiers in genetics 4 38075690
2020 CUL4B promotes aggressive phenotypes of renal cell carcinoma via upregulating c-Met expression. The international journal of biochemistry & cell biology 4 33227394
2025 NSUN2 promotes colorectal cancer progression and increases lapatinib sensitivity by enhancing CUL4B/ErbB-STAT3 signalling in a non-m5C manner. Clinical and translational medicine 3 40156167
2025 CUL4B regulates thyroid cancer differentiation and treatment sensitivity by ubiquitinating ARID1A. Translational oncology 3 40203790
2019 Embryonic Cul4b is important for epiblast growth and location of primitive streak layer cells. PloS one 3 31260508
2019 Generation of an iPSC line (SDQLCHi015-A) from peripheral blood mononuclear cells of a patient with mental retardation type 15 carrying c.1007_1011del, p.(Ile336fs) in CUL4B gene. Stem cell research 3 31678776