Affinage

CSDE1

Cold shock domain-containing protein E1 · UniProt O75534

Length
798 aa
Mass
88.9 kDa
Annotated
2026-06-09
45 papers in source corpus 28 papers cited in narrative 29 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CSDE1 (UNR) is a multi-domain, cold shock domain-containing RNA-binding protein that organizes post-transcriptional RNA regulons governing cell identity, differentiation, and oncogenesis by binding defined target mRNAs and controlling their stability and translation in a context-dependent manner (PMID:27908735, PMID:29129916, PMID:40133358). In cancer it acts predominantly as a pro-tumorigenic effector, driving the steady-state and translational output of pro-metastatic targets including VIM and RAC1 (PMID:27908735, PMID:36354136), stabilizing LDHA mRNA to fuel glycolysis and downstream H3K18-lactylation-driven transcription (PMID:41864431), and reducing tumor immunogenicity by stabilizing TCPTP to promote STAT1 dephosphorylation (PMID:36724242); in other settings it is tumor-suppressive, enforcing oncogene-induced senescence by stabilizing SASP transcripts and repressing YBX1 translation (PMID:35021076), and restraining IL-6 mRNA stability in endometrial cancer (PMID:42177550). CSDE1 controls developmental programs across systems—maintaining the undifferentiated hESC state and biasing against default neural fate (PMID:29129916), directing precerebellar and cortical neuron migration, proliferation, and synapse formation through targets including FABP7 and the Cdk6 3'UTR (PMID:31579823, PMID:24012837, PMID:40555862), and promoting hematopoietic stem/progenitor generation by enhancing ctnnb1/β-catenin translation (PMID:37874038). Mechanistically it works through its N-terminal first cold shock domain (CSD1), which mediates interaction with AGO2 to attenuate or redirect miRISC activity: it shields specific 3'UTRs (e.g. PMEPA1) from miRNA silencing (PMID:33833398), stabilizes AGO2 and pluripotency factors against ubiquitination (PMID:41624769), and promotes miR-451/miR-486 biogenesis via AGO2-dependent processing and PARN trimming (PMID:37493604, PMID:41905768). CSDE1 partners with STRAP/UNRIP to couple mRNA decay to translation, for example restraining Bach2 expression during plasma cell differentiation (PMID:30138317, PMID:40133358), forms ternary complexes with eIF3a on RPA2 mRNA to support DNA repair and dampen cGAS-STING signaling (PMID:40398074), and associates with TOM20 to localize and regulate mitochondrial mRNAs (PMID:42193230). CSDE1 undergoes regulated phosphorylation that alters its localization, ribosome association, and condensate behavior—including TBK1-mediated phosphorylation that disassembles RNA-dependent phase-separated condensates which otherwise sequester viral RNA from RIG-I-like receptors (PMID:42049720, PMID:40883018)—and its abundance is set by E3 ligases TRIM28, MKRN2, and MKRN3 that target it for ubiquitin-proteasome degradation (PMID:36354136, PMID:41757349, PMID:42204155).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 2013 Medium

    Establishing whether CSDE1 has an in vivo developmental role, the first loss-of-function study showed it is required for neuronal migration, framing it as a regulator of nervous system development rather than a generic RNA-binding factor.

    Evidence shRNA knockdown in mouse with in vivo precerebellar neuron migration analysis

    PMID:24012837

    Open questions at the time
    • No RNA targets identified
    • Migration defect not linked to specific bound transcripts
  2. 2016 High

    To define how CSDE1 acts molecularly in cancer, multi-omic mapping demonstrated it binds and controls pro-metastatic mRNAs VIM and RAC1 at both stability and translation, establishing CSDE1 as a sequence-specific post-transcriptional driver of metastasis.

    Evidence iCLIP-seq, RNA-seq, ribosome profiling, and gain/loss-of-function in melanoma cells

    PMID:27908735

    Open questions at the time
    • Domain requirements for target selection not resolved
    • Upstream regulators of CSDE1 activity unknown
  3. 2017 High

    Asking whether CSDE1 governs cell fate decisions, work in hESCs showed it maintains the undifferentiated state and prevents default neural commitment via targets including FABP7 and VIM, generalizing its regulon concept to cell-identity control.

    Evidence RNA-binding assays and reciprocal knockdown/overexpression with transcriptomics in hESCs

    PMID:29129916

    Open questions at the time
    • Mechanism distinguishing stability vs. translation control per target not resolved
    • Partner proteins not defined
  4. 2018 Medium

    To identify the protein machinery CSDE1 works with and its target classes, erythroid studies identified STRAP/UNRIP as its dominant partner, BC200 lncRNA as a direct binder controlling its localization, and CSD1 as functionally essential, anchoring a partner-and-domain framework.

    Evidence RIP-seq, reciprocal Co-IP, RNA truncation mapping, CRISPR CSD1 deletion, and immunofluorescence in erythroblasts

    PMID:29422612 PMID:30138317 PMID:30247708

    Open questions at the time
    • Biochemical mechanism of STRAP-CSDE1 cooperation not defined
    • How BC200 reorganizes CSDE1 foci unknown
  5. 2019 High

    Extending the neuronal role mechanistically, HITS-CLIP and knockdown showed CSDE1 binds neuronal development/synaptic plasticity transcripts and controls neurite, spine, and synapse formation, linking its RNA targets to specific neuronal phenotypes.

    Evidence shRNA knockdown in primary cortical neurons, HITS-CLIP, and Drosophila genetics

    PMID:31579823

    Open questions at the time
    • Individual causative target mRNAs for each phenotype not isolated
    • Relationship to FMRP target overlap not mechanistically resolved
  6. 2021 High

    Resolving how CSDE1 intersects with miRNA silencing, it was shown to bind AGO2 via CSD1 in a target-mRNA-facilitated manner and counteract miRISC at specific 3'UTRs, defining a mechanism by which it derepresses chosen targets like PMEPA1.

    Evidence Reciprocal Co-IP, RIP, domain mutagenesis, and reporter assays in melanoma

    PMID:33833398

    Open questions at the time
    • Generality of AGO2 antagonism across targets unknown
    • Structural basis of CSD1-AGO2 contact not determined
  7. 2021 Medium

    Broadening CSDE1's reach beyond mRNA fate, studies revealed it stabilizes TCPTP to dampen tumor immunogenicity and that it is itself a host co-factor for VSV replication whose point mutant generates a T-cell neo-epitope, implicating it in immune evasion and viral biology.

    Evidence Protein interaction/phosphorylation assays, ChIP, single-cell tumor formation, and mutant CSDE1 viral replication assays

    PMID:33772027 PMID:36724242

    Open questions at the time
    • Mechanism of TCPTP stabilization not detailed
    • How wild-type CSDE1 supports VSV transcription unresolved
  8. 2022 High

    Determining how CSDE1 abundance is set and how it can be oncogenic, work identified TRIM28 as an E3 ligase degrading CSDE1 (antagonized by lncRNA ARHGAP5-AS1) and placed CSDE1 in an RNAPII p-CTD/CDK7 complex driving RAC1 transcription, while a separate study showed it enforces senescence as a tumor suppressor.

    Evidence Co-IP, ubiquitination and RNA pulldown assays in HCC, ternary complex Co-IP in TNBC, and shRNA depletion with rescue in keratinocytes

    PMID:35021076 PMID:35490208 PMID:36354136

    Open questions at the time
    • What dictates pro-tumor vs. tumor-suppressor outcome is unresolved
    • Stoichiometry of the RNAPII p-CTD/CDK7 complex unknown
  9. 2023 Medium

    Refining CSDE1's role in miRNA biogenesis and developmental signaling, it was shown to promote miR-451 maturation by directing AGO2 processing and PARN trimming, and to enhance β-catenin translation to support hematopoietic stem/progenitor cell generation.

    Evidence RIP, in vitro cleavage assays, domain mutagenesis in erythroid cells, and zebrafish genetics with RIP for ctnnb1

    PMID:37493604 PMID:37874038

    Open questions at the time
    • How CSDE1 switches between miRNA biogenesis and silencing-antagonist roles unknown
    • Direct biochemical role in PARN recruitment not fully defined
  10. 2025 High

    Integrating CSDE1's regulatory logic and biophysics, studies established the Csde1-Strap complex couples Bach2 mRNA decay to translation during plasma cell differentiation, defined a TBK1-phosphorylation-controlled condensate that sequesters viral RNA from RLRs, showed eIF3a/RPA2 ternary complexes support DNA repair, and demonstrated phosphorylation-dependent ribosome association during transformation.

    Evidence RNA-interactome CRISPR screen with decay/translation assays, KO mice with LLPS and TBK1 phosphorylation assays, biotin pulldown/EMSA/Co-IP with KO mouse repair assays, and Nanopore/2D-gel/interactome proteomics

    PMID:40133358 PMID:40398074 PMID:40883018 PMID:42049720

    Open questions at the time
    • Phosphosites and kinases governing each context not unified
    • Determinants of condensate composition beyond viral RNA unclear
  11. 2026 Medium

    Expanding CSDE1's interactome and regulation, recent work showed it stabilizes AGO2 and pluripotency factors against ubiquitination via CSD1, promotes miR-486 passenger-strand cleavage, controls Cdk6, LDHA, and IL-6 mRNAs across cancers, localizes to mitochondria via TOM20, and is degraded by E3 ligases MKRN2 (forming co-condensates) and MKRN3.

    Evidence Co-IP/ubiquitination/domain-deletion assays, in vitro cleavage with KO and miRNA-seq, CLIP-seq and RIP with stability assays, TOM20 Co-IP with fractionation, and MS-based substrate screens with LLPS and KO models

    PMID:40555862 PMID:41624769 PMID:41757349 PMID:41864431 PMID:41905768 PMID:42177550 PMID:42193230 PMID:42204155

    Open questions at the time
    • Whether ubiquitination sites overlap across MKRN2/MKRN3/TRIM28 unknown
    • Functional consequence of mitochondrial mRNA regulation in disease unclear
    • How phase separation integrates with degradation not resolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved what molecular features determine whether CSDE1 stabilizes versus destabilizes a given mRNA and whether it acts as an oncogene or tumor suppressor in a particular cellular context.
  • No unifying rule for stability vs. translation control
  • No structural model of CSDE1 engaging targets with AGO2/eIF3a/STRAP
  • Context-determining cofactors and modifications not mapped

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 9 GO:0045182 translation regulator activity 5 GO:0098772 molecular function regulator activity 2 GO:0140098 catalytic activity, acting on RNA 2 GO:0140313 molecular sequestering activity 1
Localization
GO:0005829 cytosol 2 GO:0005634 nucleus 1 GO:0005739 mitochondrion 1 GO:0005840 ribosome 1
Pathway
R-HSA-1266738 Developmental Biology 5 R-HSA-1643685 Disease 4 R-HSA-392499 Metabolism of proteins 4 R-HSA-8953854 Metabolism of RNA 4 R-HSA-168256 Immune System 3 R-HSA-73894 DNA Repair 1
Partners
AGO2EIF3AMKRN2MKRN3PABPC1STRAPTOM20TRIM28
Complex memberships
CSDE1-RNAPII p-CTD-CDK7 complexCSDE1-STRAP complexCSDE1-eIF3a-RPA2 ternary complex

Evidence

Reading pass · 29 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2016 CSDE1/UNR controls pro-metastatic targets VIM and RAC1 at the level of mRNA steady-state and translation elongation/termination in melanoma cells, as identified by iCLIP sequencing, RNA sequencing, and ribosome profiling combined with loss- and gain-of-function studies. iCLIP-seq, RNA-seq, ribosome profiling, loss- and gain-of-function experiments Cancer cell High 27908735
2017 CSDE1 post-transcriptionally regulates core components of hESC identity, neuroectoderm commitment, and neurogenesis, including binding FABP7 and VIM mRNAs to regulate their stability and translation, thereby maintaining the undifferentiated hESC state and preventing default neural fate. RNA-binding assays, loss-of-function (CSDE1 knockdown/overexpression), transcriptomic analysis Nature communications High 29129916
2019 CSDE1 loss-of-function in primary mouse cortical neurons causes neurite overgrowth, abnormal dendritic spine morphology, impaired synapse formation, and impaired synaptic transmission; HITS-CLIP showed Csde1 binds targets enriched in neuronal development and synaptic plasticity pathways including FMRP targets. shRNA knockdown in primary cortical neurons, HITS-CLIP, Drosophila knockdown and mutant experiments Science advances High 31579823
2022 CSDE1 promotes oncogene-induced senescence (OIS) in primary mouse keratinocytes by two independent mechanisms: enhancing mRNA stability of SASP factor transcripts and repressing YBX1 mRNA translation; CSDE1 depletion leads to senescence bypass, immortalization, and tumor formation (tumor suppressor role in this context). shRNA depletion of CSDE1, high-throughput transcriptomic and translation assays, YBX1 rescue experiments Cell reports High 35021076
2021 CSDE1 interacts with AGO2 (the essential component of miRISC) in a manner facilitated by target mRNAs and dependent on the first cold shock domain of CSDE1; CSDE1 counteracts AGO2 binding at the 3'UTR of PMEPA1, attenuating miR-129-5p/AGO2-mediated silencing and elevating PMEPA1 expression in melanoma. Co-immunoprecipitation, RNA immunoprecipitation, functional reporter assays, domain mutagenesis Oncogene High 33833398
2021 CSDE1 promotes STAT1 dephosphorylation by stabilizing T cell protein tyrosine phosphatase (TCPTP), thereby reducing immunogenicity of tumor cells; SMYD3 mediates H3K4 trimethylation of the CSDE1 locus under mechanotransduction control, regulating CSDE1 expression. Protein interaction assays, phosphorylation assays, ChIP for H3K4me3 at CSDE1 locus, single tumor-repopulating cell tumor formation in mice Science translational medicine Medium 36724242
2022 TRIM28 acts as an E3 ligase for CSDE1 in HCC, promoting its degradation via the ubiquitin-proteasome pathway; lncRNA ARHGAP5-AS1 attenuates CSDE1-TRIM28 interaction, preventing CSDE1 degradation and allowing elevated CSDE1 to promote VIM and RAC1 translation and activate the ERK pathway. Co-immunoprecipitation, ubiquitination assays, RNA pulldown, functional cancer cell assays Clinical and translational medicine Medium 36354136
2021 A point-mutated CSDE1P5S form inhibits VSV replication by disrupting viral transcription; wild-type CSDE1 is a major cellular co-factor for VSV replication, and CSDE1P5S generates a neo-epitope recognized by non-tolerized T cells. Mutant CSDE1 expression in tumor cells, viral replication assays, compensatory viral mutation analysis Nature communications Medium 33772027
2018 CSDE1 binds transcripts involved in ribogenesis, mRNA translation, protein degradation, mitochondrial respiratory chain, and mitosis in erythroid cells; CRISPR/Cas9-mediated deletion of the first cold shock domain reduces CSDE1 function and affects RNA and protein expression of bound transcripts, including enhanced PABPC1 protein despite reduced PABPC1 mRNA (indicating post-transcriptional regulation). RNA immunoprecipitation-sequencing, CRISPR/Cas9 deletion of CSD1, RNA and protein expression analysis Scientific reports Medium 29422612
2018 CSDE1 directly interacts with BC200 lncRNA; STRAP binds BC200 indirectly via heterodimerization with CSDE1; knockdown of CSDE1 and BC200 reveal a reciprocal regulatory relationship; BC200 knockdown causes dramatic reorganization of CSDE1 into distinct nuclear foci. Proteomic analysis of BC200 RNP, reciprocal Co-IP, RNA truncation mapping, immunofluorescence after BC200 knockdown Nucleic acids research Medium 30247708
2018 STRAP (Serine/Threonine kinase receptor-associated protein) is the protein most strongly associated with CSDE1 in erythroblasts; reduced STRAP expression alters mRNA and/or protein expression of several CSDE1-bound transcripts including Vim, Elavl1, Hmbs, eIF4g3, and Pabpc4, affecting ribosome function and cell cycle control. Co-immunoprecipitation, shRNA knockdown of STRAP, RNA-binding and expression analysis PloS one Medium 30138317
2013 shRNA-mediated inhibition of Csde1 expression in mice causes failure of precerebellar neurons to complete their migration into prospective target regions, with neurons remaining in migratory paths and failing to invade the depth of the hindbrain via radial migration. shRNA knockdown in mouse, in vivo neuronal migration analysis Neuroscience Medium 24012837
2023 CSDE1 binds ctnnb1 mRNAs (encoding β-catenin) and regulates their translation but not stability, thereby enhancing β-catenin protein levels and Wnt/β-catenin signaling activity to promote hematopoietic stem and progenitor cell generation during zebrafish development. Genetic mutants and morphants in zebrafish, RNA immunoprecipitation, protein and mRNA expression analysis Development (Cambridge, England) Medium 37874038
2023 CSDE1 promotes miR-451 biogenesis in erythroid cells by binding pre-miR-451, regulating AGO2 processing through its N-terminal domains, and interacting with PARN to promote trimming of intermediate miR-451 to mature length. RNA immunoprecipitation, in vitro cleavage assays, domain deletion/mutagenesis analysis Nucleic acids research Medium 37493604
2022 CSDE1, phosphorylated C-terminal domain (p-CTD) of RNA polymerase II, and CDK7 form a complex in TNBC cells; CSDE1 downregulation weakens RNAPII p-CTD–CDK7 interaction, reducing RNAPII p-CTD expression and decreasing RAC1 transcription. Co-immunoprecipitation identifying CSDE1/RNAPII p-CTD/CDK7 complex, CSDE1 inhibition experiments with downstream signaling readouts Oncogene Medium 35490208
2022 CSDE1 directly interacts with HIV-1 Gag and NCp7; interaction with Gag is RNA-dependent and mediated by the NC domain of Gag; CSDE1 acts as an IRES trans-acting factor (ITAF), increasing HIV-1 IRES-dependent translation; NCp7 counteracts CSDE1's stimulatory effect while Gag increases it. Co-immunoprecipitation, FRET-FLIM, dual luciferase IRES assay, CSDE1 knockdown in HeLa cells, IRES point mutations Viruses Medium 36016420
2025 The Csde1-Strap complex binds Bach2 mRNA to couple its mRNA decay with translation, restraining the magnitude and duration of Bach2 protein expression during B cell to plasma cell differentiation; absence of Csde1 or Strap decouples Bach2 translation from mRNA decay, causing elevated and prolonged Bach2 expression and impaired plasma cell differentiation. RNA interactome capture-coupled CRISPR/Cas9 screen, Co-IP for Csde1-Strap complex, RNA immunoprecipitation for Bach2 mRNA binding, mRNA decay and translation assays Nature communications High 40133358
2025 CSDE1 undergoes context-dependent phosphorylation during early cellular transformation in melanoma cells, which correlates with changes in subcellular localization and promotes increased interactions with ribosomes; melanoma cells show one major CSDE1 isoform with enhanced ribosome association compared to healthy melanocytes. Long-read Nanopore sequencing, 2D gel electrophoresis, transcriptome analysis, interactome analysis (ribosome co-IP), phosphorylation mapping RNA (New York, N.Y.) Medium 40883018
2025 Csde1 directly binds the 3'UTR of Cdk6 mRNA to maintain its stability, thereby regulating CDK6 levels and controlling G1-to-S phase transition; Csde1 knockout in mice during cortical development causes prolonged G1 phase in neural progenitors, impaired proliferation, abnormal cortical lamination, and embryonic lethality. Csde1 conditional knockout in mice, CLIP-seq for 3'UTR binding, dual thymidine-labelling for cell cycle analysis, transcriptomic analysis Neuroscience bulletin Medium 40555862
2025 CSDE1 forms RNA-dependent biomolecular condensates (liquid-liquid phase separation) that sequester immunostimulatory viral RNAs, shielding them from RIG-I-like receptor recognition; upon viral infection, TBK1 kinase phosphorylates CSDE1, leading to condensate disassembly and relief of immune suppression; CSDE1-knockout mice show increased resistance to viral infection and enhanced interferon production. CSDE1 KO macrophages and mice, LLPS assays, TBK1 phosphorylation assays, interferon measurement, small molecule condensate disruption Nature communications High 42049720
2025 CSDE1 forms a ternary complex with eIF3a (protein) and RPA2 mRNA, promoting RPA2 expression and enhancing nucleotide excision repair (NER) and homologous recombination (HR) DNA repair pathways; systemic CSDE1 knockout in mice increases DNA damage following X-ray irradiation or bleomycin treatment; CSDE1 also inhibits the cGAS-STING pathway through RPA2. Biotin pulldown, EMSA, Co-IP for CSDE1-eIF3a-RPA2 ternary complex, CSDE1 knockout mouse model, comet assay, immunofluorescence Drug resistance updates Medium 40398074
2025 CSDE1 stabilizes AGO2 protein in mouse embryonic stem cells by preventing its ubiquitination; CSDE1 also stabilizes pluripotency factors NANOG, SOX2, and OCT4 through the same anti-ubiquitination mechanism; the N-terminal CSD1 domain is required for CSDE1-AGO2 interaction and AGO2 stabilization. Co-immunoprecipitation, ubiquitination assays, domain deletion (CSD1 mutant), Western blotting for pluripotency markers Frontiers in molecular biosciences Medium 41624769
2026 MKRN2 E3 ubiquitin ligase directly ubiquitinates CSDE1 at four lysine residues (K81, K91, K208, K727); MKRN2 and CSDE1 form co-localized condensates via liquid-liquid phase separation; disruption of either protein abolishes condensate formation; MKRN2 KO mice display autism-spectrum-like social behavior abnormalities. Mass spectrometry screening for MKRN2 substrates, ubiquitination mutagenesis at identified lysine residues, LLPS assays in HEK293/SH-SY5Y cells, Mkrn2-knockout mouse behavioral assays Frontiers in cellular neuroscience Medium 41757349
2026 MKRN3 (an E3 ubiquitin ligase) ubiquitinates CSDE1 as a major substrate in ovarian cancer cells, promoting CSDE1 proteolytic degradation and suppressing cancer cell proliferation. Mass spectrometry-based proteomics screens, ubiquitination assays, in vitro and in vivo proliferation assays with MKRN3 restoration Oncogenesis Medium 42204155
2026 CSDE1 directly binds IL-6 mRNA and negatively regulates its stability, thereby restraining IL-6 expression in endometrial cancer cells; loss of CSDE1 increases IL-6 mRNA stability and promotes malignant transformation. RNA immunoprecipitation, mRNA stability assays (CSDE1 KO vs. WT), IL-6 shRNA rescue, pharmacological IL-6 inhibition rescue Cell communication and signaling : CCS Medium 42177550
2026 CSDE1 enhances LDHA mRNA stability, leading to increased glycolytic activity and lactate production in gastric cancer, which then promotes HOXD9 transcription through H3K18 lactylation. RNA immunoprecipitation for CSDE1-LDHA mRNA interaction, chromatin immunoprecipitation for H3K18 lactylation at HOXD9 promoter, glycolytic assays, in vivo xenograft experiments Biochemical pharmacology Medium 41864431
2026 CSDE1 promotes passenger strand cleavage of miR-486 by facilitating AGO2-dependent removal of the passenger strand miR-486-3p; loss of CSDE1 increases miR-486-3p levels and decreases in vitro cleavage efficiency; the N-terminal CSD1 domain is required for CSDE1-AGO2 interaction and this function. In vitro cleavage assays, CSDE1 KO in leukemia cells, CSD1 domain deletion, miRNA sequencing RNA biology Medium 41905768
2026 CSDE1 associates with TOM20 (outer mitochondrial membrane import receptor) via its N-terminal region in an RNA-independent manner in sensory neurons; CSDE1 also associates with nuclear-encoded mitochondrial mRNAs enriched for inner membrane/matrix and oxidative phosphorylation pathways; CSDE1 depletion reduces mitochondrial-fraction abundance of electron transport chain mRNAs and selected mitochondrial proteins. CSDE1 immunoprecipitation-sequencing from dorsal root ganglion tissue, Co-IP for TOM20 interaction, N-terminal deletion for RNA-independent binding, subcellular fractionation Antioxidants (Basel, Switzerland) Medium 42193230
2025 CSDE1 and PABPC1 form a complex that caps coronavirus poly(A) tails, slowing their shortening (deadenylation) and protecting viral mRNA stability during infection. Biochemical complex identification, poly(A)-tail length profiling during coronavirus infection bioRxivpreprint Low

Source papers

Stage 0 corpus · 45 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2016 UNR/CSDE1 Drives a Post-transcriptional Program to Promote Melanoma Invasion and Metastasis. Cancer cell 127 27908735
2017 A post-transcriptional program coordinated by CSDE1 prevents intrinsic neural differentiation of human embryonic stem cells. Nature communications 62 29129916
2020 The role of CSDE1 in translational reprogramming and human diseases. Cell communication and signaling : CCS 51 31987048
2022 N6 -methyladenosine-modified lncRNA ARHGAP5-AS1 stabilises CSDE1 and coordinates oncogenic RNA regulons in hepatocellular carcinoma. Clinical and translational medicine 40 36354136
2019 Disruptive variants of CSDE1 associate with autism and interfere with neuronal development and synaptic transmission. Science advances 38 31579823
2019 UNR/CSDE1 Expression Is Critical to Maintain Invasive Phenotype of Colorectal Cancer through Regulation of c-MYC and Epithelial-to-Mesenchymal Transition. Journal of clinical medicine 32 31027221
2023 Epigenetic modification of CSDE1 locus dictates immune recognition of nascent tumorigenic cells. Science translational medicine 30 36724242
2022 Coordinated post-transcriptional control of oncogene-induced senescence by UNR/CSDE1. Cell reports 25 35021076
2021 Oncolytic virotherapy induced CSDE1 neo-antigenesis restricts VSV replication but can be targeted by immunotherapy. Nature communications 25 33772027
2021 CSDE1 attenuates microRNA-mediated silencing of PMEPA1 in melanoma. Oncogene 21 33833398
2020 LINC00205 promotes malignancy in lung cancer by recruiting FUS and stabilizing CSDE1. Bioscience reports 20 32808651
2013 The control of precerebellar neuron migration by RNA-binding protein Csde1. Neuroscience 20 24012837
2018 Csde1 binds transcripts involved in protein homeostasis and controls their expression in an erythroid cell line. Scientific reports 19 29422612
2018 Comprehensive analysis of the BC200 ribonucleoprotein reveals a reciprocal regulatory function with CSDE1/UNR. Nucleic acids research 19 30247708
2021 Wnt/β-catenin pathway and cell adhesion deregulation in CSDE1-related intellectual disability and autism spectrum disorders. Molecular psychiatry 17 33867523
2022 Reduced miR-371b-5p expression drives tumor progression via CSDE1/RAC1 regulation in triple-negative breast cancer. Oncogene 14 35490208
2023 CSDE1 promotes miR-451 biogenesis. Nucleic acids research 13 37493604
2021 The CDT of Helicobacter hepaticus induces pro-survival autophagy and nucleoplasmic reticulum formation concentrating the RNA binding proteins UNR/CSDE1 and P62/SQSTM1. PLoS pathogens 12 33662035
2018 Strap associates with Csde1 and affects expression of select Csde1-bound transcripts. PloS one 11 30138317
2020 Cold Shock Domain Containing E1 (CSDE1) Protein is Overexpressed and Can be Targeted to Inhibit Invasiveness in Pancreatic Cancer Cells. Proteomics 9 32170829
2018 miR-132 and miR-212 cluster function as a tumor suppressor in thyroid cancer cells by CSDE1 mediated post-transcriptional program. International journal of clinical and experimental pathology 8 31938190
2021 A de novo CSDE1 variant causing neurodevelopmental delay, intellectual disability, neurologic and psychiatric symptoms in a child of consanguineous parents. American journal of medical genetics. Part A 6 34519148
2023 The RNA-binding protein CSDE1 promotes hematopoietic stem and progenitor cell generation via translational control of Wnt signaling. Development (Cambridge, England) 4 37874038
2022 A de novo truncating variant in CSDE1 in an adult-onset neuropsychiatric phenotype without intellectual disability. European journal of medical genetics 4 35026469
2024 Leader RNA facilitates snakehead vesiculovirus (SHVV) replication by interacting with CSDE1 and hnRNP A3. Fish & shellfish immunology 3 39341378
2022 Upstream of N-Ras (Unr/CSDE1) Interacts with NCp7 and Gag, Modulating HIV-1 IRES-Mediated Translation Initiation. Viruses 3 36016420
2025 A Csde1-Strap complex regulates plasma cell differentiation by coupling mRNA translation and decay. Nature communications 2 40133358
2013 Deregulated Nras expression in knock-in animals harboring a gammaretroviral long terminal repeat at the Nras/Csde1 locus. PloS one 2 23418499
2025 Csde1 Mediates Neurogenesis via Post-transcriptional Regulation of the Cell Cycle. Neuroscience bulletin 1 40555862
2025 CSDE1 regulates the miR-20a-5p/TMBIM6 axis in melanoma. RNA (New York, N.Y.) 1 41093770
2026 CSDE1 stabilizes AGO2 in embryonic stem cells. Frontiers in molecular biosciences 0 41624769
2026 Liquid-liquid phase separation couples MKRN2-mediated ubiquitination of CSDE1 with neurodevelopmental disorders. Frontiers in cellular neuroscience 0 41757349
2026 CSDE1 Drives Glycolysis and the Progression of Prostate Cancer Through RAC1-Dependent RAS/MAPK Activation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 0 41808419
2026 CSDE1-mediated histone lactylation modification of the HOXD9 promoter promotes gastric cancer progression. Biochemical pharmacology 0 41864431
2026 CSDE1 promotes passenger strand cleavage of miR-486. RNA biology 0 41905768
2026 CSDE1 promotes viral immune evasion through RNA-dependent and phosphorylation-modulated liquid-liquid phase separation. Nature communications 0 42049720
2026 Stress-inducible circSCLT1 scaffolds HNRNPA1/CSDE1 to amplify IL1B/NF-κB signaling in TNBC via mRNA stabilization, suppressor degradation, and stress granule shielding. Cancer letters 0 42092680
2026 Loss of cold shock domain-containing protein E1 (CSDE1) function enhances mRNA stability of interleukin-6 and promotes malignant transformation in endometrial cancer cells. Cell communication and signaling : CCS 0 42177550
2026 CSDE1 in tumour immunology: spatiotemporal translational reprogramming and immune microenvironment remodeling. Journal of translational medicine 0 42192424
2026 CSDE1 Associates with TOM20 and Mitochondrial Protein-Encoding mRNAs in Sensory Neurons. Antioxidants (Basel, Switzerland) 0 42193230
2026 The central precocious puberty-associated gene MKRN3 is a tumor suppressor regulating CSDE1 ubiquitination in ovarian cancer. Oncogenesis 0 42204155
2025 CSDE1 enhances genotoxic drug resistance in cancer by modulating RPA2 through CSDE1-eIF3a regulatory complex. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 0 40398074
2025 Context-dependent phosphorylation of CSDE1 drives interactions with ribosomes. RNA (New York, N.Y.) 0 40883018
2025 CSDE1 depletion inhibits tumor progression through enhancing B-cell infiltration in NSCLC. Cell death & disease 0 41353256
2024 High-resolution RNA-sequencing reveals TRIM33 :: CSDE1 gene fusion in metastasizing vulvar melanoma. Melanoma research 0 39291968

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