Affinage

CPEB2

Cytoplasmic polyadenylation element-binding protein 2 · UniProt Q7Z5Q1

Length
589 aa
Mass
64.9 kDa
Annotated
2026-04-28
37 papers in source corpus 22 papers cited in narrative 22 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CPEB2 is a cytoplasmic RNA-binding protein that functions as a master translational regulator, controlling the translation, stability, and localization of diverse target mRNAs through recognition of cytoplasmic polyadenylation elements (CPEs) in their 3′-UTRs via its dual RNA recognition motifs and zinc-finger domain. CPEB2 represses translation elongation of bound mRNAs such as HIF-1α by interacting with eEF2 to inhibit ribosome-stimulated GTP hydrolysis, a repression relieved by oxidative stress through NPGPx-mediated disulfide bond dynamics (PMID:22157746, PMID:26446990). In a context- and target-dependent manner, CPEB2 also activates translation of mRNAs including GRASP1 (supporting AMPAR trafficking and hippocampal synaptic plasticity), UCP1 and PRDM16 (driving brown adipose thermogenesis), PDGFRα (enabling pulmonary alveologenesis), and VGLUT2 (maintaining presynaptic vesicle pools), with alternative splicing generating functionally opposing isoforms (CPEB2A as repressor, CPEB2B as activator of targets such as HIF-1α and TWIST1 in breast cancer) (PMID:29141213, PMID:30177570, PMID:39305947, PMID:32295602, PMID:38992696, PMID:28904175). Loss of CPEB2 in mice causes neonatal respiratory failure from parasympathetic hyperactivation due to derepressed choline acetyltransferase translation, impaired hippocampal memory, defective alveologenesis, and obesity from brown adipose dysfunction (PMID:27810937, PMID:29141213, PMID:32295602, PMID:39305947).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 2003 Medium

    Identifying CPEB2 as a novel RNA-binding protein with dual RRMs and a zinc finger that preferentially binds poly(U) and localizes to the cytoplasm established it as a candidate post-transcriptional regulator.

    Evidence RNA-binding assays, immunofluorescence, RT-PCR expression profiling in mouse testis and HeLa cells

    PMID:12672660

    Open questions at the time
    • No specific mRNA targets identified
    • Functional consequence of RNA binding not demonstrated
    • Mechanism of translational regulation unknown
  2. 2010 High

    Demonstrating that miR-92 and miR-26 target conserved sites in the CPEB2 3′-UTR revealed that CPEB2 expression itself is subject to miRNA-mediated post-transcriptional control, adding an upstream regulatory layer.

    Evidence Luciferase reporters with mutated miRNA sites, miRNA overexpression/depletion with endogenous CPEB2 mRNA quantification

    PMID:20660482

    Open questions at the time
    • Physiological contexts where miRNA regulation of CPEB2 is rate-limiting unknown
    • Whether miRNA control differs across CPEB2 isoforms not tested
  3. 2011 High

    Discovering that CPEB2 directly binds eEF2 to inhibit ribosome-stimulated GTP hydrolysis provided the first molecular mechanism for CPEB2-mediated translational repression, demonstrating regulation at the elongation rather than initiation step.

    Evidence In vitro GTP hydrolysis reconstitution, co-immunoprecipitation, RNA-IP, ribosome profiling for HIF-1α mRNA

    PMID:22157746

    Open questions at the time
    • Whether elongation-level repression applies to all CPEB2 targets or only HIF-1α
    • Structural basis of CPEB2-eEF2 interaction unresolved
    • How target specificity is achieved at the elongation step unclear
  4. 2015 High

    Showing that NPGPx forms a redox-sensitive disulfide bond with CPEB2 to maintain its repressive function under low oxidative stress, while high ROS disrupts this bond to derepress HIF-1α translation, established a direct redox-sensing mechanism governing CPEB2 activity.

    Evidence Disulfide bond trapping, RNA-IP, polysome/translation assays in NPGPx-deficient cells

    PMID:26446990

    Open questions at the time
    • Identity of the reactive cysteine residues on CPEB2 not fully mapped
    • Whether redox regulation extends to CPEB2 targets beyond HIF-1α unknown
  5. 2016 High

    CPEB2 knockout causing neonatal respiratory failure via derepressed ChAT translation and parasympathetic hyperactivation demonstrated the first essential in vivo role for CPEB2 as a translational repressor in a defined neural circuit.

    Evidence Global and cholinergic neuron-specific CPEB2 KO mice, pulmonary acetylcholine measurements, plethysmography, anticholinergic rescue

    PMID:27810937

    Open questions at the time
    • Direct CPEB2–ChAT mRNA binding not shown by RIP in this study
    • Whether the ZZ domain mediates ChAT repression specifically not tested
  6. 2017 High

    Two concurrent studies established that CPEB2 can activate translation of specific targets (GRASP1 in hippocampal neurons) and that alternative splicing generates functionally opposing isoforms (CPEB2A repressor vs. CPEB2B activator of TWIST1/HIF-1α), resolving the apparent paradox of CPEB2 as both repressor and activator.

    Evidence Forebrain-specific CPEB2 cKO with LTP/behavior rescue (GRASP1); isoform-specific knockdown with EMT/invasion readouts in TNBC cells

    PMID:28904175 PMID:29141213

    Open questions at the time
    • Structural basis for isoform-specific functional divergence not determined
    • Whether CPEB2A and CPEB2B bind distinct or overlapping mRNA target sets genome-wide unknown
    • Direct CPEB2B–TWIST1 mRNA interaction not validated by RIP
  7. 2018 High

    Demonstrating that CPEB2 activates Ucp1 long-3′-UTR isoform translation in brown adipose tissue, with KO mice showing impaired thermogenesis, extended CPEB2's translational activation role to metabolic physiology.

    Evidence CPEB2 KO mice, Ucp1S-only mouse model, metabolic/thermogenic assays, AAV rescue, reporter assay

    PMID:30177570

    Open questions at the time
    • How CPEB2 distinguishes between long and short Ucp1 3′-UTR isoforms mechanistically unclear
    • Whether β3-adrenergic signaling modifies CPEB2 activity directly or indirectly not resolved
  8. 2019 Medium

    Identification of CPEB2 as a regulator of p53 mRNA translation and TJP1 mRNA stability/polyadenylation broadened the target repertoire to tumor suppression and epithelial junction assembly, revealing CPEB2 can control mRNA stability in addition to translation.

    Evidence CRISPR KO in MCF10A with polysome profiling for p53; dsRNA KD in porcine trophectoderm with poly(A) tail assay for TJP1

    PMID:30145997 PMID:31185986

    Open questions at the time
    • Direct CPEB2–p53 mRNA interaction validated only by polysome shift, not by RIP in the initial study
    • Whether mRNA stability and translational regulation are mechanistically separable activities of CPEB2 not established
  9. 2020 High

    Showing CPEB2 activates PDGFRα mRNA translation to support alveolar myofibroblast proliferation, with KO mice developing emphysema-like pathology, established CPEB2 as essential for postnatal lung development.

    Evidence CPEB2 KO mice, RNA-IP confirming direct binding, reporter assay, primary cell rescue, histology, plethysmography

    PMID:32295602

    Open questions at the time
    • Whether CPEB2 regulates additional mRNAs in alveolar progenitors genome-wide not profiled
    • Mechanism of translational activation (poly(A) lengthening vs. other) for PDGFRα not distinguished
  10. 2021 Medium

    Establishing that CPEB2 binds p53 mRNA via its RRM and ZF domains and that p53 transcriptionally activates CPEB2, forming a negative feedback loop, provided the first evidence for reciprocal transcriptional–translational regulation involving CPEB2.

    Evidence RIP with domain-deletion mutants, mRNA stability assay, ChIP for p53 on CPEB2 promoter, luciferase reporter

    PMID:34362680

    Open questions at the time
    • Feedback loop dynamics not modeled quantitatively
    • Whether this loop operates in tissues beyond renal cancer not tested
  11. 2022 Medium

    Discovery that CPEB2 itself is stabilized by METTL3-mediated m6A methylation (read by IGF2BP3), and that CPEB2 stabilizes SRSF5 mRNA to regulate alternative splicing of ETS1 in glioma endothelial cells, placed CPEB2 within an epitranscriptomic regulatory cascade affecting blood-tumor barrier integrity.

    Evidence RIP, m6A assays, KD in vitro and xenograft in vivo, alternative splicing analysis

    PMID:36064747

    Open questions at the time
    • Which m6A sites on CPEB2 mRNA are functional not mapped at nucleotide resolution
    • Whether m6A regulation of CPEB2 is general or glioma-specific unknown
  12. 2022 Medium

    Demonstrating that CPEB2 directs subcellular translocation of Tjp1 mRNA from nuclei to the apical membrane with poly(A) tail modulation in mouse blastocysts revealed a role in mRNA localization beyond translational control.

    Evidence Cpeb2 KD in mouse embryos, RNA FISH for Tjp1 localization, poly(A) tail PCR, blastocyst outgrowth and embryo transfer

    PMID:35133290

    Open questions at the time
    • Motor/adaptor proteins mediating CPEB2-dependent mRNA transport not identified
    • Whether CPEB2 localizes other mRNAs in embryos not tested
  13. 2024 High

    Showing CPEB2 drives axonal translation of VGLUT2 mRNA to maintain presynaptic vesicle pools and protein-synthesis-dependent LTP in glutamatergic neurons established CPEB2 as a critical mediator of local presynaptic translation.

    Evidence Glutamatergic and presynaptic-specific Cpeb2 cKO mice, RIP-seq, synaptosome fractionation, microfluidic axotomy, electrophysiology, behavior

    PMID:38992696

    Open questions at the time
    • Full presynaptic translatome regulated by CPEB2 not comprehensively defined
    • Whether CPEB2 activates or derepresses VGLUT2 translation mechanistically not distinguished
  14. 2024 High

    Identifying PRDM16 as a translational target of CPEB2 in brown fat, with CPEB2 KO causing myogenic gene upregulation and obesity rescued by PRDM16 restoration, revealed CPEB2 as a gatekeeper of brown adipocyte identity.

    Evidence Global and adipose-specific CPEB2 cKO, polysomal profiling, reporter assay, RNA-seq, AAV-mediated PRDM16 rescue

    PMID:39305947

    Open questions at the time
    • Whether CPEB2 regulates Prdm16 via poly(A) tail lengthening or another mechanism not resolved
    • Relationship between UCP1 and PRDM16 translational activation by CPEB2 not integrated

Open questions

Synthesis pass · forward-looking unresolved questions
  • The structural basis of CPEB2's dual repressor/activator activity, the complete target-specific determinants dictating repression versus activation, and the genome-wide landscape of CPEB2-bound mRNAs across tissues remain to be established.
  • No high-resolution structure of CPEB2 or its ZZ domain bound to RNA or eEF2
  • No comprehensive CLIP-seq or TRIBE map of CPEB2 targets across tissues
  • Mechanistic basis for target-specific repression vs. activation not resolved at the molecular level

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 10 GO:0140110 transcription regulator activity 8 GO:0098772 molecular function regulator activity 2
Localization
GO:0005829 cytosol 3
Pathway
R-HSA-392499 Metabolism of proteins 6 R-HSA-8953854 Metabolism of RNA 3 R-HSA-112316 Neuronal System 2 R-HSA-1266738 Developmental Biology 2 R-HSA-74160 Gene expression (Transcription) 2
Partners
EEF2GPX7GRASP1HIF1APDGFRAPRDM16TP53

Evidence

Reading pass · 22 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2011 CPEB2 interacts directly with elongation factor eEF2 to reduce eEF2/ribosome-triggered GTP hydrolysis in vitro, thereby slowing peptide elongation of CPEB2-bound mRNAs (including HIF-1α mRNA) in vivo; under oxidative stress, CPEB2 dissociates from HIF-1α mRNA, allowing rapid HIF-1α synthesis. In vitro GTP hydrolysis assay, co-immunoprecipitation, RNA-immunoprecipitation, ribosome profiling, mutagenesis The EMBO journal High 22157746
2003 CPEB2 contains two RNA recognition motifs and a Zn-finger structure, preferentially binds poly(U) sequences, localizes to the cytoplasm, and is expressed postmeiotically in haploid spermatids, suggesting a role in translational regulation of stored mRNAs. RNA-binding assay (poly(U) preference), immunofluorescence localization in transfected HeLa cells, RT-PCR expression profiling, chromosomal mapping Biology of reproduction Medium 12672660
2015 NPGPx (GPx7) forms an intermolecular disulfide bond with CPEB2 under low oxidative stress to maintain CPEB2-mediated repression of HIF-1α mRNA translation; high oxidative stress disrupts this bond, releasing CPEB2 from HIF-1α mRNA and elevating HIF-1α translation. Co-immunoprecipitation, disulfide bond trapping, RNA-immunoprecipitation, NPGPx-deficient cells with polysome/translation readouts Nucleic acids research High 26446990
2010 miR-92 and miR-26 bind conserved sites in the 3'-UTRs of CPEB2, CPEB3, and CPEB4 at paralogous positions, co-regulating their mRNA levels; validated by mutagenesis of miRNA-binding sites in luciferase reporter constructs and miRNA overexpression/depletion. Luciferase reporter assay with site mutagenesis, miRNA overexpression and depletion, qPCR of endogenous CPEB2 mRNA Nucleic acids research High 20660482
2016 CPEB2 represses translation of choline acetyltransferase (ChAT) mRNA in the dorsal motor nucleus of vagus; CPEB2 knockout leads to upregulated ChAT translation, excess acetylcholine production, hyperactivated parasympathetic-induced bronchoconstriction, and neonatal respiratory failure. CPEB2 global and cholinergic neuron-specific knockout mice, Western blotting, pulmonary acetylcholine measurement, whole-body plethysmography, anticholinergic bronchodilator rescue The Journal of neuroscience High 27810937
2017 CPEB2 activates translation of GRASP1 mRNA to promote recycling and surface expression of AMPA receptors; forebrain-specific CPEB2 conditional knockout reduces surface AMPAR levels and impairs long-term potentiation and hippocampus-dependent memory, rescued by ectopic CPEB2 or GRASP1 expression. Conditional knockout mice, polysome profiling/translation assays, surface AMPAR assay, LTP electrophysiology, behavioral tests (fear conditioning, Morris water maze), AAV rescue Cell reports High 29141213
2018 CPEB2 promotes translation of the long 3'-UTR isoform of Ucp1 mRNA (Ucp1L) in brown adipose tissue downstream of β3 adrenergic receptor signaling; CPEB2 knockout mice show reduced UCP1 protein levels and impaired thermogenesis, rescued by ectopic CPEB2 expression. CPEB2 knockout mice, mouse model expressing only Ucp1S, Western blotting, metabolic/thermogenic assays, AAV rescue, reporter assay The EMBO journal High 30177570
2017 The CPEB2B splice isoform (containing exon 4) acts as a translational activator of TWIST1 and HIF-1α mRNAs to drive epithelial-to-mesenchymal transition and anoikis resistance in triple-negative breast cancer, while CPEB2A does not activate these pathways; isoform-specific knockdown established opposing functions. RNA-seq after isoform-specific knockdown, Western blotting, functional anoikis/invasion assays, in vivo metastasis The Journal of biological chemistry Medium 28904175
2019 CPEB2 mediates TJP1 (ZO-1) mRNA stability through binding the 3'-UTR cytoplasmic polyadenylation element; CPEB2 depletion in porcine trophectoderm impairs tight-junction assembly and blastocyst formation without affecting TJP1 transcription. dsRNA knockdown, immunocytochemistry, Western blotting, RT-PCR of poly(A)-tail-bearing TJP1 mRNA Reproduction, fertility, and development Medium 30145997
2020 CPEB2 activates PDGFRα mRNA translation in alveolar myofibroblast progenitors to support their proliferation during pulmonary alveologenesis; CPEB2 KO mice develop emphysema-like phenotypes with impaired alveolar septum formation; ectopic CPEB2 rescues KO myofibroblast proliferation. CPEB2 knockout mice, RNA-immunoprecipitation, Western blotting, reporter assay, primary myofibroblast culture, histology, plethysmography, ectopic expression rescue Journal of biomedical science High 32295602
2020 CPEB2 directly binds the CPE site in the 3'-UTR of HIF-1α mRNA to inhibit its translation; in trophoblasts, miR-210 targets CPEB2 to relieve this repression and increase HIF-1α, forming a positive feedback loop that limits trophoblast syncytialization. RNA-immunoprecipitation, luciferase reporter assay with 3'-UTR, CPEB2 overexpression with HIF-1α protein readout, miR-210 inhibitor rescue in syncytialization assay Biology of reproduction Medium 31616934
2019 CPEB2 (isoform A) translationally regulates p53 mRNA, as validated by polysome profiling; CPEB2 knockout in MCF10A cells reduces p53 protein and promotes oncogenic phenotypes including EMT, migration, invasion, stem-like cell expansion, and tumor formation in vivo. CRISPR/Cas9 knockout, siRNA knockdown, polysome profiling, in vitro oncogenesis assays, in vivo xenograft BMC cancer Medium 31185986
2021 CPEB2 binds to CPE sites in the p53 3'-UTR (requiring its RNA recognition motif and zinc finger domains) and decreases p53 mRNA stability and translation; p53 transcriptionally activates CPEB2, forming a negative feedback loop that controls renal cancer cell proliferation and migration. RNA-immunoprecipitation, domain-deletion mutagenesis (RRM and ZF), mRNA stability assay, luciferase reporter, ChIP, Western blotting, functional proliferation/migration assays Journal of genetics and genomics Medium 34362680
2022 CPEB2 promotes SRSF5 mRNA stability by directly binding it; CPEB2's m6A methylation (via METTL3/IGF2BP3) increases CPEB2 mRNA stability in glioma endothelial cells; CPEB2-stabilized SRSF5 promotes ETS1 exon inclusion, driving transcription of tight-junction proteins to regulate blood-tumor barrier permeability. RNA-immunoprecipitation, Western blotting, knockdown in vitro and in vivo (xenograft mice), alternative splicing analysis, m6A methylation assay Communications biology Medium 36064747
2022 CPEB2 mediates Tjp1 mRNA translocalisation from nuclei to apical membrane and poly(A) tail length variation in mouse blastocysts; Cpeb2 knockdown prevents apical localisation of Tjp1 mRNA and impairs tight-junction assembly, blastocyst formation, and implantation. Cpeb2 knockdown, RNA FISH for Tjp1 mRNA localization, poly(A) tail PCR assay, blastocyst outgrowth assay, embryo transfer Reproduction (Cambridge, England) Medium 35133290
2023 CPEB2 increases p21 mRNA stability in glioma cells to induce G1 cell cycle arrest and inhibit proliferation/promote apoptosis; CPEB2 overexpression and knockdown experiments established this anti-tumor mechanism. CPEB2 overexpression/knockdown, mRNA stability assay, flow cytometry cell cycle analysis, in vitro and in vivo tumor growth assays Scientific reports Medium 38158431
2023 CPEB2 enhances ARPC5 mRNA stability in multiple myeloma cells; RIP confirmed direct CPEB2–ARPC5 mRNA interaction; CPEB2-promoted ARPC5 expression drives MM cell proliferation and angiogenesis. RNA-immunoprecipitation, actinomycin D mRNA stability assay, cycloheximide chase, FISH co-localization, functional assays (CCK-8, colony formation, tube formation) Journal of orthopaedic surgery and research Medium 37231521
2024 CPEB2 drives axonal translation of Slc17a6 (VGLUT2) mRNA in glutamatergic neurons to maintain the releasable pool of synaptic vesicles and support presynaptic, protein-synthesis-dependent LTP and hippocampus-dependent memory consolidation. Glutamatergic neuron-specific and presynaptic-specific Cpeb2 conditional KO mice, electrophysiology (LTP), RNA-immunoprecipitation coupled with transcriptomics, Western blotting, luciferase reporter, synaptosome fractionation, microfluidic axotomy platform, FM4-64FX synaptic vesicle loading, behavioral tests Journal of biomedical science High 38992696
2024 CPEB2 activates translation of Prdm16 mRNA in brown adipose tissue; CPEB2-null BAT shows upregulation of myogenic genes and weight gain; ectopic PRDM16 in CPEB2-deficient BAT restores gene expression and reduces obesity. CPEB2 global and adipose-specific conditional KO mice, RNA sequencing, RT-qPCR, Western blotting, polysomal profiling, luciferase reporter assay, AAV-mediated rescue Molecular metabolism High 39305947
2024 CPEB2 inhibits SSTR3 translation by binding the CPE site in the 3'-UTR of SSTR3 mRNA and reducing poly(A) tail length, thereby promoting trophoblast proliferation, migration, invasion, and EMT; this mechanism is validated in a rat preeclampsia model. RIP assay, dual-luciferase reporter assay, poly(A) tail PCR assay, CPEB2 overexpression/knockdown, Western blotting, functional assays, in vivo rat PE model with AAV9 Biochimica et biophysica acta. Molecular basis of disease Medium 38648900
2025 CPEB2 promotes ANGPTL3 mRNA translation by binding the 3'-UTR of ANGPTL3 mRNA and increasing its recruitment to high-translating polysomes; polysomal profiling confirmed increased ANGPTL3 transcript abundance in active polysomes upon CPEB2 overexpression; CPEB2/ANGPTL3 feedback loop drives podocyte injury in nephrotic syndrome. RIP assay, polysomal profiling, overexpression/knockdown, in vivo AAV9-shCPEB2 in ADR-induced NS mice Scientific reports Medium 41219382
2025 Drosophila ORB2 (ortholog of human CPEB2-4) represses target mRNA translation through its C-terminal ZZ zinc-binding domain; tethered ORB2 or hCPEB2 (but not ORB/hCPEB1) repress luciferase reporter translation; the ZZ domain is necessary and sufficient for repression and mediates interaction with the Cup repressive complex. Tethered reporter assay in S2 cells, ZZ domain deletion mutants, RNA immunoprecipitation, co-immunoprecipitation of repressive complex, early embryo translatome profiling bioRxiv (preprint)preprint Medium bio_10.1101_2025.07.10.664187

Source papers

Stage 0 corpus · 37 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2017 TUG1 mediates methotrexate resistance in colorectal cancer via miR-186/CPEB2 axis. Biochemical and biophysical research communications 87 28302487
2017 LncRNA CCAT1 modulates the sensitivity of paclitaxel in nasopharynx cancers cells via miR-181a/CPEB2 axis. Cell cycle (Georgetown, Tex.) 69 28358263
2011 CPEB2-eEF2 interaction impedes HIF-1α RNA translation. The EMBO journal 62 22157746
2003 CPEB2, a novel putative translational regulator in mouse haploid germ cells. Biology of reproduction 46 12672660
2017 Identification of microRNA 885-5p as a novel regulator of tumor metastasis by targeting CPEB2 in colorectal cancer. Oncotarget 36 28460469
2017 CPEB2 Activates GRASP1 mRNA Translation and Promotes AMPA Receptor Surface Expression, Long-Term Potentiation, and Memory. Cell reports 31 29141213
2022 CPEB2 m6A methylation regulates blood-tumor barrier permeability by regulating splicing factor SRSF5 stability. Communications biology 29 36064747
2010 CPEB2, CPEB3 and CPEB4 are coordinately regulated by miRNAs recognizing conserved binding sites in paralog positions of their 3'-UTRs. Nucleic acids research 28 20660482
2018 CPEB2-dependent translation of long 3'-UTR Ucp1 mRNA promotes thermogenesis in brown adipose tissue. The EMBO journal 25 30177570
2020 A positive feedback self-regulatory loop between miR-210 and HIF-1α mediated by CPEB2 is involved in trophoblast syncytialization: implication of trophoblast malfunction in preeclampsia†. Biology of reproduction 23 31616934
2019 Tumor suppressor role of cytoplasmic polyadenylation element binding protein 2 (CPEB2) in human mammary epithelial cells. BMC cancer 21 31185986
2020 The RNA binding protein CPEB2 regulates hormone sensing in mammary gland development and luminal breast cancer. Science advances 19 32440535
2017 Splice variants of cytosolic polyadenylation element-binding protein 2 (CPEB2) differentially regulate pathways linked to cancer metastasis. The Journal of biological chemistry 16 28904175
2015 NPGPx modulates CPEB2-controlled HIF-1α RNA translation in response to oxidative stress. Nucleic acids research 16 26446990
2021 STAT1 mediated long non-coding RNA LINC00504 influences radio-sensitivity of breast cancer via binding to TAF15 and stabilizing CPEB2 expression. Cancer biology & therapy 15 34908514
2016 Deficiency of CPEB2-Confined Choline Acetyltransferase Expression in the Dorsal Motor Nucleus of Vagus Causes Hyperactivated Parasympathetic Signaling-Associated Bronchoconstriction. The Journal of neuroscience : the official journal of the Society for Neuroscience 15 27810937
2023 CPEB2 inhibit cell proliferation through upregulating p21 mRNA stability in glioma. Scientific reports 14 38158431
2020 Osthole inhibited cell proliferation and induced cell apoptosis through decreasing CPEB2 expression via up-regulating miR-424 in endometrial carcinoma. Journal of receptor and signal transduction research 13 31971049
2018 CPEB2 Is Necessary for Proper Porcine Meiotic Maturation and Embryonic Development. International journal of molecular sciences 13 30322039
2021 A p53/CPEB2 negative feedback loop regulates renal cancer cell proliferation and migration. Journal of genetics and genomics = Yi chuan xue bao 11 34362680
2020 CPEB2-activated PDGFRα mRNA translation contributes to myofibroblast proliferation and pulmonary alveologenesis. Journal of biomedical science 9 32295602
2023 CPEB2 enhances cell growth and angiogenesis by upregulating ARPC5 mRNA stability in multiple myeloma. Journal of orthopaedic surgery and research 8 37231521
2024 CPEB2-activated axonal translation of VGLUT2 mRNA promotes glutamatergic transmission and presynaptic plasticity. Journal of biomedical science 6 38992696
2023 CPEB2 Suppresses Hepatocellular Carcinoma Epithelial-Mesenchymal Transition and Metastasis through Regulating the HIF-1α/miR-210-3p/CPEB2 Axis. Pharmaceutics 6 37514073
2023 MIR-147B Regulated Proliferation and Apoptosis of Gastric Cancer Cells by Targeting CPEB2 Via the PTEN Pathway. Balkan journal of medical genetics : BJMG 3 36880039
2019 Cytoplasmic polyadenylation element binding protein 2 (CPEB2) is required for tight-junction assembly for establishment of porcine trophectoderm epithelium. Reproduction, fertility, and development 3 30145997
2025 LncRNA CCAT1 decreases the sensitivity to doxorubicin in lung cancer cells by regulating miR-181a/CPEB2 axis. Medical oncology (Northwood, London, England) 2 40089944
2024 CPEB2-activated Prdm16 translation promotes brown adipocyte function and prevents obesity. Molecular metabolism 2 39305947
2022 Regulation of Tjp1 mRNA by CPEB2 for tight junction assembly in mouse blastocyst. Reproduction (Cambridge, England) 2 35133290
2024 CPEB2 inhibits preeclampsia progression by regulating SSTR3 translation through polyadenylation. Biochimica et biophysica acta. Molecular basis of disease 1 38648900
2019 Corrigendum to: Cytoplasmic polyadenylation element binding protein 2 (CPEB2) is required for tight-junction assembly for establishment of porcine trophectoderm epithelium. Reproduction, fertility, and development 1 31039976
2026 Spitz Melanocytoma With a Novel CPEB2::MAP3K2 Rearrangement: A Case Report. Journal of cutaneous pathology 0 41924997
2025 Identification of lncRNA biomarkers for keloid diagnosis and functional characterization of CPEB2-AS1. Burns : journal of the International Society for Burn Injuries 0 40101610
2025 A Maternal Gene Regulator CPEB2 Is Involved in Mating-Induced Egg Maturation in the Cnaphalocrocis medinalis. Insects 0 40725298
2025 miR-363-5p regulates liver disease via the MAPK/ERK signaling pathway by targeting CPEB2 in chicken. Poultry science 0 40803288
2025 Human Mesenchymal Stem Cell Derived Exosomes Endowed with miR-13474 as a Therapeutic Delivery Vehicle for Diabetic Wound Healing by Targeting the CPEB2/TWIST1 Axis. ACS applied bio materials 0 41092373
2025 A CPEB2/ANGPTL3 feedback loop promotes the progression of podocyte injury in nephrotic syndrome. Scientific reports 0 41219382