Affinage

CIDEA

Lipid transferase CIDEA · UniProt O60543

Length
219 aa
Mass
24.7 kDa
Annotated
2026-04-28
64 papers in source corpus 29 papers cited in narrative 29 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CIDEA is a CIDE-domain protein that functions as a central regulator of lipid droplet dynamics, energy metabolism, and transcriptional control in adipose tissue, liver, and mammary gland. On lipid droplets, CIDEA promotes droplet enlargement and fusion by forming trans-complexes at droplet–droplet contact sites through an amphipathic helix that binds phosphatidic acid in the phospholipid monolayer, while simultaneously inhibiting lipolysis (PMID:26609809, PMID:20810722, PMID:18509062). CIDEA also suppresses AMPK activity by binding the AMPK-β subunit at the endoplasmic reticulum and promoting its ubiquitin-dependent proteasomal degradation, and indirectly inhibits UCP1 thermogenic activity in brown adipose tissue through a non-mitochondrial mechanism (PMID:18480843, PMID:27923808, PMID:12910269). In a concentration-dependent manner, CIDEA translocates to the nucleus where it acts as a transcriptional coactivator of C/EBPβ to drive milk-lipid secretion in mammary epithelium and modulates the UCP1 enhancer by inhibiting LXRα repression and strengthening PPARγ binding during adipocyte britening (PMID:22245780, PMID:31563853).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 1998 High

    The initial identification of CIDEA as a DFF45-homologous cell death activator established that its C-terminal domain is necessary and sufficient for apoptosis induction, while the N-terminal CIDE domain mediates inhibition by DFF45, framing the protein as a modular apoptosis effector.

    Evidence Transfection of deletion mutants in 293T cells with DNA fragmentation and caspase-inhibitor assays

    PMID:9564035

    Open questions at the time
    • Physiological cell type for CIDE-domain-mediated apoptosis unclear
    • Endogenous DFF45 interaction not validated in vivo
  2. 2003 High

    Generation of Cidea-null mice revealed that Cidea suppresses UCP1 activity and restrains BAT thermogenesis and lipolysis, positioning it as a negative regulator of energy expenditure — knockout mice were lean, hypermetabolic, and resistant to diet-induced obesity.

    Evidence Cidea knockout mouse with metabolic rate, cold challenge, and direct UCP1 activity assays

    PMID:12910269

    Open questions at the time
    • Molecular mechanism of UCP1 inhibition unresolved
    • Whether Cidea acts on UCP1 directly or indirectly was unclear
  3. 2005 High

    RNAi in human adipocytes demonstrated that CIDEA cell-autonomously suppresses lipolysis and that TNF-α feeds back to repress CIDEA via JNK, establishing a regulatory loop between CIDEA and inflammatory signaling.

    Evidence siRNA knockdown in human adipocytes with lipolysis and TNF-α secretion readouts plus JNK inhibitor

    PMID:15919794

    Open questions at the time
    • Direct anti-lipolytic target of CIDEA not identified
    • Whether TNF-α/JNK axis acts transcriptionally or post-transcriptionally was incompletely resolved
  4. 2007 High

    Two studies clarified CIDEA regulation: its protein is controlled by ubiquitin-proteasomal degradation with K23 as the principal ubiquitination site, while its transcription is driven by PPARα and PPARγ through a shared PPRE in the promoter — establishing dual-level control of CIDEA abundance.

    Evidence Cycloheximide chase, ubiquitination assays with K-to-A mutants; ChIP, EMSA, and reporter assays for PPRE

    PMID:17462989 PMID:17711404

    Open questions at the time
    • E3 ubiquitin ligase responsible for K23 ubiquitination not identified
    • Relative contributions of PPARα vs PPARγ in different tissues unclear
  5. 2008 High

    A series of studies repositioned CIDEA from a mitochondrial protein to a lipid-droplet-resident factor: CIDEA co-localizes with perilipin on lipid droplets and drives droplet enlargement; separately, it interacts with AMPK-β at the ER to promote AMPK-β degradation, and its transcription is repressed by TNF-α/NF-κB and regulated by PGC-1α/RIP140 via ERRα.

    Evidence GFP-fusion imaging and co-localization in adipocytes; co-IP and ubiquitination of AMPK-β; reporter assays identifying NF-κB site and ERRα-dependent regulation

    PMID:18480843 PMID:18509062 PMID:18607384 PMID:18794372

    Open questions at the time
    • Lipid-droplet targeting domain not yet mapped
    • Mechanism by which lipid-droplet CIDEA inhibits UCP1 still unresolved
  6. 2010 High

    Domain mapping showed that the C-terminal 104 amino acids are sufficient for lipid-droplet targeting and triglyceride accumulation while the N-terminal domain is required for droplet enlargement/fusion, and SREBP-1c was identified as a direct transcriptional activator of Cidea via a promoter SRE element in hepatocytes.

    Evidence Deletion constructs in 3T3-L1/COS-1 cells with lipolysis readout; ChIP, EMSA, and reporter assays with SREBP-1c-null hepatocytes

    PMID:20575761 PMID:20810722

    Open questions at the time
    • Whether N- and C-terminal domains cooperate through dimerization was not established
    • Relative importance of PPARs vs SREBP-1c in hepatic Cidea expression unclear
  7. 2012 High

    CIDEA was shown to function as a transcriptional coactivator: in mammary epithelial cells it translocates to the nucleus via a bipartite NLS, binds C/EBPβ, displaces HDAC1 from the Xdh promoter, and drives milk-lipid secretion — extending CIDEA's role beyond lipid-droplet biology to gene regulation.

    Evidence Co-IP of CIDEA–C/EBPβ, ChIP at Xdh promoter, Cidea-deficient mouse mammary glands, ectopic re-expression

    PMID:22245780

    Open questions at the time
    • Whether nuclear coactivator function extends to other promoters beyond Xdh was unknown
    • Whether nuclear translocation occurs in adipocytes was not tested
  8. 2015 High

    The biophysical mechanism of lipid droplet fusion was resolved: CIDEA forms trans-complexes at LD–LD contact sites through N-terminal and C-terminal dimerization, and an amphipathic helix embeds in the phospholipid monolayer where it binds phosphatidic acid to increase barrier permeability and enable lipid transfer.

    Evidence Amphipathic helix mutagenesis, PA-binding assay, reconstitution of LD–LD docking in brown adipocytes

    PMID:26609809

    Open questions at the time
    • Structural model of the CIDEA trans-complex at atomic resolution lacking
    • Regulation of PA availability at contact sites not addressed
  9. 2016 High

    The long-standing question of how lipid-droplet-localized CIDEA inhibits mitochondrial UCP1 was partially resolved: overexpressed CIDEA suppresses UCP1 activity in isolated BAT mitochondria without changing UCP1 protein levels and without being mitochondrially localized, confirming an indirect inhibitory mechanism.

    Evidence UCP1 activity assay in isolated mitochondria from aP2-hCidea transgenic mice plus subcellular localization

    PMID:27923808

    Open questions at the time
    • Identity of the intermediary signal between lipid droplets and mitochondria unknown
    • Whether AMPK-β degradation accounts for UCP1 suppression not tested
  10. 2019 High

    Nuclear CIDEA function was extended to adipocyte thermogenesis: during britening of human adipocytes, CIDEA shuttles from lipid droplets to the nucleus in a concentration-dependent manner, where it inhibits LXRα-mediated repression and strengthens PPARγ binding at the UCP1 enhancer to drive UCP1 transcription.

    Evidence CRISPR knockout in primary human adipocytes with rescue, UCP1 enhancer reporter, nuclear fractionation, chromatin binding assays

    PMID:31563853

    Open questions at the time
    • How CIDEA concentration sensing triggers nuclear import is unknown
    • Whether LXRα inhibition and PPARγ enhancement are direct or indirect remains incompletely defined
  11. 2023 Medium

    Hepatic Cidea expression was found to be rhythmically repressed by Egr-1 and regulated by DNMT3B-mediated promoter methylation controlling SREBP-1c access, adding circadian and epigenetic layers to the transcriptional regulation of Cidea in liver lipid metabolism.

    Evidence Egr-1 knockout mice with circadian profiling; DNMT3B overexpression/knockdown with bisulfite sequencing and ChIP in hepatocytes

    PMID:36964140 PMID:37703946

    Open questions at the time
    • Whether Egr-1 directly binds the Cidea promoter or acts indirectly not fully established
    • Interaction between circadian and epigenetic regulatory layers not tested

Open questions

Synthesis pass · forward-looking unresolved questions
  • The molecular intermediary by which lipid-droplet-localized CIDEA indirectly suppresses mitochondrial UCP1 activity remains unidentified, and the E3 ligase(s) mediating CIDEA ubiquitination at K23 have not been determined.
  • No candidate E3 ligase for CIDEA ubiquitination identified
  • Indirect mechanism of UCP1 suppression entirely unresolved
  • High-resolution structure of full-length CIDEA or the LD fusion trans-complex not available

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 3 GO:0140110 transcription regulator activity 2 GO:0008289 lipid binding 1
Localization
GO:0005634 nucleus 3 GO:0005811 lipid droplet 3 GO:0005783 endoplasmic reticulum 1
Pathway
R-HSA-1430728 Metabolism 5 R-HSA-5357801 Programmed Cell Death 2 R-HSA-74160 Gene expression (Transcription) 2
Partners
CEBPBDFF45NR1H3PLIN1PPARGPRKAB1

Evidence

Reading pass · 29 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1998 CIDEA activates apoptosis in mammalian cells; its C-terminal region is necessary and sufficient for cell killing, while the N-terminal CIDE domain (homologous to DFF45) is required for DFF45-mediated inhibition of CIDEA-induced apoptosis. CIDEA-induced DNA fragmentation is inhibited by DFF45 but not by caspase inhibitors. Transfection of deletion mutants in 293T cells, DNA fragmentation assay, inhibition studies with DFF45 and caspase inhibitors The EMBO journal High 9564035
2003 Cidea is expressed at high levels in brown adipose tissue mitochondria and directly suppresses UCP1 activity, thereby regulating thermogenesis and lipolysis; Cidea-null mice have increased metabolic rate, elevated BAT lipolysis, and resistance to diet-induced obesity and diabetes. Cidea knockout mouse model, metabolic rate measurements, cold challenge, direct suppression of UCP1 activity assay Nature genetics High 12910269
2005 In human adipocytes, CIDEA regulates lipolysis; RNAi-mediated depletion of CIDEA stimulates lipolysis and increases TNF-alpha secretion by a post-transcriptional mechanism. TNF-alpha in turn decreases CIDEA expression via the JNK (c-Jun N-terminal kinase) pathway. RNA interference in human adipocytes, lipolysis assay, TNF-alpha secretion measurement, pharmacological inhibition of JNK Diabetes High 15919794
2007 Cidea protein is regulated by ubiquitin-proteasome-mediated degradation; it is polyubiquitinated primarily at Lys23 in its N-terminal region, and mutation of N-terminal lysine residues (N-5KA mutant) greatly stabilizes the protein. Cycloheximide chase, proteasome inhibitor treatment, ubiquitination assay, site-directed mutagenesis of lysine residues in multiple cell lines and brown adipocytes The Biochemical journal High 17711404
2007 Cidea gene expression in mouse liver is transcriptionally regulated by both PPARalpha and PPARgamma through a shared proximal PPRE element (Cidea-PPRE1 at -680/-668) in the Cidea promoter. Transactivation/luciferase reporter assays, gel-shift (EMSA), chromatin immunoprecipitation with PPARalpha and PPARgamma ligands The Journal of biological chemistry High 17462989
2008 Cidea colocalizes with lipid droplets (not mitochondria) in human and mouse adipocytes, co-localizing with perilipin; ectopic expression of Cidea-GFP greatly enhances lipid droplet size in preadipocytes and COS cells, and Cidea is regulated by PPARgamma. Fluorescence microscopy (GFP fusion protein), co-localization with perilipin, RNAi lipolysis assay, rosiglitazone treatment in mice Proceedings of the National Academy of Sciences of the United States of America High 18509062
2008 Cidea forms a complex with the beta subunit of AMPK (but not alpha or gamma subunits) in the endoplasmic reticulum, promoting ubiquitination-dependent proteasomal degradation of the AMPK-beta subunit, thereby reducing AMPK protein levels and enzymatic activity in brown adipose tissue. Co-immunoprecipitation in vivo, co-localization in ER, co-expression ubiquitination assay, AMPK activity measurement in Cidea-/- adipocytes The EMBO journal High 18480843
2008 RIP140 and PGC-1alpha regulate CIDEA expression in brown adipocytes: PGC-1alpha induces while RIP140 represses CIDEA promoter activity via estrogen-related receptor alpha (ERRalpha) and NRF-1 binding sites; RIP140 directly interacts with PGC-1alpha to suppress its coactivator activity. Luciferase reporter assays, promoter deletion analysis, protein-protein interaction assay (RIP140-PGC-1alpha), ectopic expression in brown adipocytes and nonadipogenic lines Molecular and cellular biology High 18794372
2008 In apoptotic conditions, CIDEa redistributes from mitochondria to the nucleus in HeLa cells, and nuclear accumulation correlates with increased cell death. Immunocytochemistry and subcellular fractionation with tetracycline-inducible CIDEa expression, camptothecin/valinomycin treatment General physiology and biophysics Medium 18645223
2009 Cold exposure down-regulates CIDEA mRNA and protein in rat interscapular BAT via sympathetically activated beta3-adrenoreceptors, and this effect is blocked by propranolol (non-selective beta-blocker) or SR59230A (selective beta3-antagonist). Cold exposure in vivo, pharmacological blockade with beta-adrenoreceptor antagonists, norepinephrine turnover measurement, qRT-PCR and western blot Biochemical and biophysical research communications Medium 19577538
2010 The carboxy-terminal 104 amino acids of Cidea are sufficient for lipid droplet targeting and triglyceride accumulation, while the N-terminal domain is required for the development of enlarged (fused) lipid droplets; Cidea promotes lipid storage by inhibiting lipolysis (reduces basal glycerol release in differentiated 3T3-L1 adipocytes). Expression of deletion constructs in 3T3-L1 and COS-1 cells, fluorescence microscopy, triglyceride measurement, glycerol release assay Journal of lipid research High 20810722
2010 SREBP-1c directly binds the Cidea promoter via a sterol-regulatory element (SRE) in mouse hepatocytes, mediating insulin-induced Cidea expression; Cidea in turn mediates SREBP-1c-dependent hepatic lipid accumulation. Luciferase reporter assay, EMSA, ChIP, adenovirus-mediated SREBP-1c overexpression and Cidea knockdown in hepatocytes from wild-type and SREBP-1c-null mice The Biochemical journal High 20575761
2010 In human adipocytes, insulin decreases CIDEA expression, and CIDEA (not CIDEC) is responsible for starvation-induced apoptosis; RNAi depletion of CIDEA inhibits apoptosis similarly to insulin treatment. siRNA knockdown of CIDEA/CIDEC in human adipocytes, apoptosis assays, lipid droplet size measurement Journal of lipid research Medium 20154362
2011 Insulin regulates CIDEA expression via PI3K and specifically through Akt1/2-dependent pathway; Akt1/2 knockdown prevents insulin-induced CIDEA downregulation and its anti-apoptotic effect. PI3K inhibitors (wortmannin, PI-103), Akt inhibitor (API-2), siRNA depletion of Akt1/2, apoptosis assay in human adipocytes Journal of lipid research Medium 21636835
2011 CIDEA binds to liver X receptors (LXRs) in human white adipocytes and regulates their transcriptional activity; CIDEA localizes to both cytoplasm and nucleus in human white adipocytes. Protein-protein binding experiments, transactivation assays, cell fractionation of human white adipocytes FEBS letters Medium 21315073
2011 In pancreatic beta-cells, palmitic acid-induced apoptosis upregulates Cidea downstream of FoxO1; FoxO1 suppression reduces palmitic acid-induced Cidea expression and apoptosis, placing Cidea as a critical downstream target of FoxO1 in FFA-induced beta-cell death. siRNA knockdown of Cidea and FoxO1 in beta-cells, palmitic acid treatment, apoptosis assay Molecular and cellular endocrinology Medium 21945815
2012 Cidea functions as a transcriptional coactivator of C/EBPbeta in mammary epithelial cells: it translocates to the nucleus via a nuclear bipartite signal, physically interacts with C/EBPbeta, promotes C/EBPbeta association with the Xdh (XOR) promoter, and displaces HDAC1, thereby inducing XOR expression and milk lipid secretion. Nuclear fractionation, co-immunoprecipitation of Cidea with C/EBPbeta, ChIP for C/EBPbeta and HDAC1 on Xdh promoter, Cidea-deficient mouse mammary glands, ectopic expression in vivo Nature medicine High 22245780
2012 Cidea promotes hepatic lipid accumulation by sensing dietary saturated fatty acids; saturated FAs induce Cidea expression via SREBP1c, and Cidea protein stability in hepatocytes is increased by FA treatment. Cidea overexpression in mouse liver increases hepatic lipid and large lipid droplet formation; Cidea deficiency reduces lipid accumulation in ob/ob mice. Adenoviral overexpression and knockdown in mouse liver and hepatocytes, ob/ob mouse model, SREBP1c knockdown, FA treatment, lipid droplet measurement Hepatology (Baltimore, Md.) High 22278400
2014 Cidea is required for normal sebaceous gland lipid storage and sebum secretion; Cidea-deficient mice accumulate many small lipid droplets in sebocytes instead of large ones, leading to reduced skin surface lipids, dry hair, and defective thermoregulation. Overexpression of Cidea in human SZ95 sebocytes increases lipid storage and large LD formation. Cidea knockout mice, sebocyte lipid droplet imaging, skin surface lipid analysis, overexpression in SZ95 human sebocytes Molecular and cellular biology High 24636991
2015 CIDEA promotes lipid droplet fusion via an amphipathic helix that embeds in the LD phospholipid monolayer and binds phosphatidic acid (PA); CIDEA forms trans-complexes at LD-LD contact sites through its N-terminal domain and C-terminal dimerization region, interacting with cone-shaped PA to increase phospholipid barrier permeability and enable lipid transfer between droplets. Mutagenesis of amphipathic helix, PA-binding assay, reconstitution of LD-LD docking, CIDEA complex analysis at contact sites, brown adipocyte differentiation assay eLife High 26609809
2015 Transgenic expression of human Cidea in mouse adipose tissue increases adipose tissue expandability; in obese transgenic mice, Cidea preserves perilipin-1 and Akt expression in adipose tissue, reduces macrophage accumulation, and maintains adiponectin expression, resulting in enhanced insulin sensitivity. aP2-hCidea transgenic mice, high-fat diet challenge at thermoneutrality, western blot for perilipin/Akt, adiponectin measurement, insulin tolerance test Nature communications High 26118629
2016 Cidea protein levels in brown fat are regulated post-transcriptionally (not transcriptionally) and are elevated in the thermogenically recruited state; overexpressed Cidea markedly suppresses UCP1 activity in isolated BAT mitochondria without changing UCP1 protein levels, but Cidea itself is not localized to mitochondria, implying an indirect inhibitory mechanism. aP2-hCidea transgenic mice, UCP1 activity assay in isolated mitochondria, Cidea protein/mRNA quantification across recruitment states, subcellular localization American journal of physiology. Endocrinology and metabolism High 27923808
2019 CIDEA acts as a transcriptional regulator in human adipocytes: during britening, it shuttles from lipid droplets to the nucleus via a nuclear bipartite signal in a concentration-dependent manner, where it inhibits LXRalpha repression of the UCP1 enhancer and strengthens PPARgamma binding to the UCP1 enhancer, driving UCP1 transcription and thermogenesis. CRISPR-Cas9nD10A knockout of CIDEA in primary human adipocytes, nuclear fractionation, UCP1 enhancer reporter assay, chromatin binding assays, re-expression rescue iScience High 31563853
2021 ER stress increases Cidea mRNA levels (partly through mRNA stabilization) and stabilizes CIDE-A protein against proteasomal degradation; elevated CIDE-A expression under ER stress accompanies increased cell death. ATF6 negatively regulates Cidea mRNA under ER stress. Acute and chronic ER stress induction in PCCL3 thyrocytes and other cell types, mRNA stability assays, proteasome inhibition, ATF6 modulation, cell death assays JCI insight Medium 33661766
2022 METTL16 methyltransferase upregulates CIDEA expression in hepatocytes through m6A-dependent translational regulation, contributing to NAFLD progression. m6A sequencing, METTL16 overexpression and knockdown in HepG2 cells, quantification of CIDEA expression PeerJ Low 36518278
2022 SENP2 (SUMO-specific protease 2) increases CIDEA expression by desumoylating ERRalpha, which then cooperates with PGC-1alpha to activate CIDEA transcription; palmitate treatment increases SENP2 and CIDEA levels and SENP2 or ERRalpha knockdown abolishes palmitate-induced CIDEA expression. SENP2 overexpression in 3T3-L1 adipocytes, ERRalpha knockdown, siRNA, palmitate treatment, luciferase reporter assay Biochemical and biophysical research communications Medium 37748256
2023 Egr-1 transcription factor rhythmically couples with and represses Cidea expression in mouse liver; Egr-1 deletion disrupts this rhythmic coupling, leading to increased Cidea expression, large lipid droplet formation, and age-related hepatic metabolic dysfunction. Egr-1 knockout mice, circadian gene expression profiling, lipid droplet size analysis, circadian light-shift experiment Nature communications Medium 36964140
2023 DNMT3B methylates the CIDEA promoter to suppress its expression; LPS-induced reduction of DNMT3B leads to promoter hypomethylation, increased SREBP-1c binding, and elevated CIDEA expression promoting hepatic lipid accumulation. Cidea knockdown reverses LPS-induced lipogenesis. DNMT3B overexpression/knockdown in mice and hepatocytes, bisulfite methylation assay of CIDEA promoter, SREBP-1c ChIP, CIDEA knockdown rescue Cellular and molecular gastroenterology and hepatology Medium 37703946
2008 TNF-alpha negatively regulates CIDEA transcription in human adipocytes at least in part through an NF-kappaB binding site at position -163/-151 in the human CIDEA promoter; basal transcription is confined to the 97 bp upstream of the TSS. Luciferase reporter assays with deletion and mutant constructs, EMSA, TNF-alpha treatment of human adipocytes and 3T3-L1 cells International journal of obesity (2005) Medium 18607384

Source papers

Stage 0 corpus · 64 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2003 Cidea-deficient mice have lean phenotype and are resistant to obesity. Nature genetics 405 12910269
2008 Cidea is associated with lipid droplets and insulin sensitivity in humans. Proceedings of the National Academy of Sciences of the United States of America 306 18509062
1998 CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor. The EMBO journal 282 9564035
2012 Cidea promotes hepatic steatosis by sensing dietary fatty acids. Hepatology (Baltimore, Md.) 159 22278400
2005 A human-specific role of cell death-inducing DFFA (DNA fragmentation factor-alpha)-like effector A (CIDEA) in adipocyte lipolysis and obesity. Diabetes 156 15919794
2008 Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue. The EMBO journal 138 18480843
2008 A functional interaction between RIP140 and PGC-1alpha regulates the expression of the lipid droplet protein CIDEA. Molecular and cellular biology 136 18794372
2015 The brown adipocyte protein CIDEA promotes lipid droplet fusion via a phosphatidic acid-binding amphipathic helix. eLife 127 26609809
2012 Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids. Nature medicine 99 22245780
2015 Cidea improves the metabolic profile through expansion of adipose tissue. Nature communications 89 26118629
2007 Transcriptional regulation of Cidea, mitochondrial cell death-inducing DNA fragmentation factor alpha-like effector A, in mouse liver by peroxisome proliferator-activated receptor alpha and gamma. The Journal of biological chemistry 83 17462989
2019 CIDEA Transcriptionally Regulates UCP1 for Britening and Thermogenesis in Human Fat Cells. iScience 77 31563853
2009 Functional analysis of FSP27 protein regions for lipid droplet localization, caspase-dependent apoptosis, and dimerization with CIDEA. American journal of physiology. Endocrinology and metabolism 72 19843876
2008 Evidence for an important role of CIDEA in human cancer cachexia. Cancer research 54 19010897
2005 The CIDEA gene V115F polymorphism is associated with obesity in Swedish subjects. Diabetes 50 16186410
2016 UCP1 inhibition in Cidea-overexpressing mice is physiologically counteracted by brown adipose tissue hyperrecruitment. American journal of physiology. Endocrinology and metabolism 45 27923808
2018 High expression of cell death-inducing DFFA-like effector a (CIDEA) promotes milk fat content in dairy cows with clinical ketosis. Journal of dairy science 40 30594378
2010 Identification of the lipid droplet targeting domain of the Cidea protein. Journal of lipid research 40 20810722
2014 Cidea control of lipid storage and secretion in mouse and human sebaceous glands. Molecular and cellular biology 38 24636991
2010 Sterol-regulatory-element-binding protein 1c mediates the effect of insulin on the expression of Cidea in mouse hepatocytes. The Biochemical journal 37 20575761
2010 Differential roles of CIDEA and CIDEC in insulin-induced anti-apoptosis and lipid droplet formation in human adipocytes. Journal of lipid research 32 20154362
2010 Promoter hypermethylation of CIDEA, HAAO and RXFP3 associated with microsatellite instability in endometrial carcinomas. Gynecologic oncology 32 20211485
2023 The rhythmic coupling of Egr-1 and Cidea regulates age-related metabolic dysfunction in the liver of male mice. Nature communications 31 36964140
2015 Effects of a High Fat Diet and Voluntary Wheel Running Exercise on Cidea and Cidec Expression in Liver and Adipose Tissue of Mice. PloS one 27 26176546
2011 Differential regulation of CIDEA and CIDEC expression by insulin via Akt1/2- and JNK2-dependent pathways in human adipocytes. Journal of lipid research 27 21636835
2008 Cell death-inducing DNA fragmentation factor alpha-like effector A (CIDEA) gene V115F (G-->T) polymorphism is associated with phenotypes of metabolic syndrome in Japanese men. Metabolism: clinical and experimental 25 18328351
2022 METTL16-mediated translation of CIDEA promotes non-alcoholic fatty liver disease progression via m6A-dependent manner. PeerJ 24 36518278
2007 Regulation of Cidea protein stability by the ubiquitin-mediated proteasomal degradation pathway. The Biochemical journal 24 17711404
2018 Effects of a high energy and low protein diet on hepatic and plasma characteristics and Cidea and Cidec mRNA expression in liver and adipose tissue of laying hens with fatty liver hemorrhagic syndrome. Animal science journal = Nihon chikusan Gakkaiho 23 30523654
2022 Ban-xia-xie-xin-tang ameliorates hepatic steatosis by regulating Cidea and Cidec expression in HFD-fed mice. Phytomedicine : international journal of phytotherapy and phytopharmacology 22 35908522
2011 Suppression of FoxO1/cell death-inducing DNA fragmentation factor α-like effector A (Cidea) axis protects mouse β-cells against palmitic acid-induced apoptosis. Molecular and cellular endocrinology 20 21945815
2007 CIDE-A is expressed in liver of old mice and in type 2 diabetic mouse liver exhibiting steatosis. Comparative hepatology 20 17472743
2010 Association of the cell death-inducing DNA fragmentation factor alpha-like effector A (CIDEA) gene V115F (G/T) polymorphism with phenotypes of metabolic syndrome in a Chinese population. Diabetes research and clinical practice 19 21106268
2022 CIDEA Regulates De Novo Fatty Acid Synthesis in Bovine Mammary Epithelial Cells by Targeting the AMPK/PPARγ Axis and Regulating SREBP1. Journal of agricultural and food chemistry 18 36040348
2010 Cide-a and Cide-c are induced in the progression of hepatic steatosis and inhibited by eicosapentaenoic acid. Prostaglandins, leukotrienes, and essential fatty acids 18 20542418
2013 The genetic contribution of CIDEA polymorphisms, haplotypes and loci interaction to obesity in a Han Chinese population. Molecular biology reports 15 24057179
2008 Molecular cloning, chromosomal location and expression pattern of porcine CIDEa and CIDEc. Molecular biology reports 15 18311595
2018 SREBP1c mediates the effect of acetaldehyde on Cidea expression in Alcoholic fatty liver Mice. Scientific reports 14 29352167
2014 Maternal diet amplifies the hepatic aging trajectory of Cidea in male mice and leads to the development of fatty liver. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 14 24481968
2009 Saturated fatty acids stimulate and insulin suppresses CIDE-A expression in bovine mammary epithelial cells. Biochemical and biophysical research communications 14 19427838
2015 PPARγ regulated CIDEA affects pro-apoptotic responses in glioblastoma. Cell death discovery 12 27551468
2014 Adipose tissue CIDEA is associated, independently of weight variation, to change in insulin resistance during a longitudinal weight control dietary program in obese individuals. PloS one 12 24983748
2021 Cell death-associated lipid droplet protein CIDE-A is a noncanonical marker of endoplasmic reticulum stress. JCI insight 11 33661766
2011 CIDEA interacts with liver X receptors in white fat cells. FEBS letters 11 21315073
2009 Acute cold exposure-induced down-regulation of CIDEA, cell death-inducing DNA fragmentation factor-alpha-like effector A, in rat interscapular brown adipose tissue by sympathetically activated beta3-adrenoreceptors. Biochemical and biophysical research communications 11 19577538
2008 Characterization of the human CIDEA promoter in fat cells. International journal of obesity (2005) 11 18607384
2008 Redistribution of cell death-inducing DNA fragmentation factor-like effector-a (CIDEa) from mitochondria to nucleus is associated with apoptosis in HeLa cells. General physiology and biophysics 11 18645223
2019 Plasticity of histone modifications around Cidea and Cidec genes with secondary bile in the amelioration of developmentally-programmed hepatic steatosis. Scientific reports 10 31745102
2021 Development of CIDEA reporter mouse model and its application for screening thermogenic drugs. Scientific reports 9 34531447
2023 DNMT3B Alleviates Liver Steatosis Induced by Chronic Low-grade LPS via Inhibiting CIDEA Expression. Cellular and molecular gastroenterology and hepatology 8 37703946
2022 Hypermethylation-Mediated Silencing of CIDEA, MAL and PCDH17 Tumour Suppressor Genes in Canine DLBCL: From Multi-Omics Analyses to Mechanistic Studies. International journal of molecular sciences 8 35409379
2021 Down-Regulation of CIDEA Promoted Tumor Growth and Contributed to Cisplatin Resistance by Regulating the JNK-p21/Bad Signaling Pathways in Esophageal Squamous Cell Carcinoma. Frontiers in oncology 7 33614508
2024 Attenuation of brown adipocyte whitening in high-fat diet-induced obese rats: Effects of melatonin and β-hydroxybutyrate on Cidea, Fsp27 and MT1 expression. Diabetes, obesity & metabolism 6 39118207
2025 Hu-lu-su-pian ameliorates hepatic steatosis by regulating CIDEA expression in AKT-driven MASLD mice. Frontiers in pharmacology 4 39958875
2021 In silico interactions of statins with cell death-inducing DNA fragmentation factor-like effector A (CIDEA). Chemico-biological interactions 3 34022192
2017 Distribution and quantitative analysis of CIDEa and CIDEc in broiler chickens: accounting for differential fat deposition between strains. British poultry science 3 29219006
2023 SUMO-specific protease 2 regulates lipid droplet size through ERRα-mediated CIDEA expression in adipocytes. Biochemical and biophysical research communications 2 37748256
2019 CIDEA and CIDEC are regulated by CREB and are not induced during fasting in grass carp Ctenopharyngodon idella adipocytes. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2 31028911
2025 Comparative effect of high intensity interval training and moderate intensity continuous training on metabolic improvements and regulation of Cidea and Cidec in obese C57BL/6 mice. PloS one 1 40305497
2025 Activation of Focal Adhesion Pathway by CIDEA as Key Regulatory Axis in Lipid Deposition in Goat Intramuscular Precursor Adipocytes. Animals : an open access journal from MDPI 1 40867704
2021 CIDEA expression in SAT from adolescent girls with obesity and unfavorable patterns of abdominal fat distribution. Obesity (Silver Spring, Md.) 1 34672413
2025 Cidea Targeting Protects Cochlear Hair Cells and Hearing Function From Drug- and Noise-Induced Damage. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 0 41262044
2023 Use of CIDEA Reporter Mouse Model for Screening Thermogenic Fat-Activating Drugs. Methods in molecular biology (Clifton, N.J.) 0 37076679
2022 Exercise-induced beige adipogenesis of iWAT in Cidea reporter mice. BMB reports 0 35000670