Affinage

NR1H3

Oxysterols receptor LXR-alpha · UniProt Q13133

Round 2 corrected
Length
447 aa
Mass
50.4 kDa
Annotated
2026-04-29
62 papers in source corpus 22 papers cited in narrative 23 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

NR1H3 (LXRα) is a ligand-activated nuclear receptor that functions as the principal intracellular oxysterol and cholesterol sensor, forming obligate heterodimers with RXR to bind LXR response elements and transcriptionally regulate cholesterol homeostasis, lipid metabolism, and inflammatory gene programs (PMID:9013544, PMID:9630215). LXRα activation drives cholesterol efflux via ABCA1 induction, bile acid synthesis through CYP7A1 upregulation, lipogenesis via SREBP-1, and apolipoprotein E expression in macrophages (PMID:11035776, PMID:11090131, PMID:11149950). Its anti-inflammatory transrepression function is mechanistically separable from transactivation: ligand-dependent SUMO2/3 conjugation targets LXRα to TLR-responsive promoters where it stabilizes NCoR corepressor complexes, while SIRT1-mediated deacetylation at K432 positively regulates canonical target gene activation (PMID:17218271, PMID:17936707, PMID:16143103). A dominant-negative NR1H3 p.Arg415Gln mutation that disrupts heterodimerization and transcriptional activity was identified in familial multiple sclerosis (PMID:27253448).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 1995 High

    Establishing that LXRα functions as an RXR-dependent transcription factor resolved how this orphan receptor engages DNA and responds to retinoid ligands, providing the foundational heterodimer framework for all subsequent LXR biology.

    Evidence Transient transfection/reporter assays, EMSA, and dominant-negative constructs in cell lines

    PMID:7744246

    Open questions at the time
    • Endogenous ligand unknown at this stage
    • In vivo relevance of heterodimer not yet tested
  2. 1997 High

    Identification of oxysterols as physiological LXRα ligands and the CYP7A1 LXRE de-orphanized the receptor, establishing the cholesterol–oxysterol–bile acid feedforward axis.

    Evidence Ligand-binding and reporter assays with 24(S),25-epoxycholesterol and 24(S)-hydroxycholesterol, EMSA on CYP7A1 promoter

    PMID:9013544

    Open questions at the time
    • In vivo requirement for LXRα in cholesterol sensing not yet demonstrated
  3. 1998 High

    Genetic deletion of LXRα proved it is the essential in vivo cholesterol sensor required for hepatic CYP7A1 induction and protection against cholesterol overload.

    Evidence LXRα knockout mice challenged with dietary cholesterol accumulate hepatic cholesterol with loss of CYP7A1 induction

    PMID:9630215

    Open questions at the time
    • Redundancy with LXRβ not fully dissected
    • PKA/PKC phosphorylation sites not mapped despite pharmacological evidence of kinase modulation (PMID:9500983)
  4. 2000 High

    Demonstrating that LXRα transcriptionally induces ABCA1-mediated cholesterol efflux and the SREBP-1 lipogenic program expanded the receptor's role from bile acid synthesis to whole-body lipid homeostasis.

    Evidence Retroviral overexpression, dominant-negative constructs, cholesterol efflux assays in macrophages including Tangier disease controls; in vivo pharmacology with T0901317 in mice and hamsters

    PMID:11035776 PMID:11090131

    Open questions at the time
    • Mechanism linking LXRα-driven lipogenesis to triglyceride accumulation side effects not resolved
    • PPAR–LXRα hierarchy established (PMID:11135616) but direct transcriptional regulation of NR1H3 promoter by PPARs not fully mapped
  5. 2001 High

    Identification of apoE as a direct LXRα target in macrophages, validated by double-KO mice, connected LXRα to reverse cholesterol transport beyond ABCA1.

    Evidence EMSA on ME.1/ME.2 enhancers, reporter assays, LXRα/β double-knockout mice

    PMID:11149950

    Open questions at the time
    • Relative contributions of LXRα vs. LXRβ to macrophage apoE regulation unclear
  6. 2005 High

    Discovery that LXRs transrepress TLR-induced inflammatory genes independently of p65/IRF3 revealed a fundamentally distinct anti-inflammatory mechanism separable from classical transactivation.

    Evidence Macrophage reporter assays, siRNA knockdown, combinatorial perturbation with GR and PPARγ

    PMID:16143103

    Open questions at the time
    • Molecular mechanism of corepressor retention at inflammatory promoters not yet defined
  7. 2007 High

    Two parallel discoveries resolved the post-translational logic governing LXRα: SIRT1 deacetylates K432 to promote transactivation, while ligand-induced SUMO2/3 conjugation enables NCoR-dependent transrepression—showing how a single receptor independently controls metabolic activation and inflammatory repression.

    Evidence Co-IP, site-directed mutagenesis of K432, in vivo SIRT1 loss-of-function (PMID:17936707); SUMOylation assays, ChIP on inflammatory promoters, natural/synthetic ligand dissection (PMID:17218271)

    PMID:17218271 PMID:17936707

    Open questions at the time
    • Identity of the E3 SUMO ligase responsible for LXRα SUMOylation not established
    • Whether K432 deacetylation and SUMOylation are coordinated or mutually exclusive is unknown
    • Reciprocal cross-talk with RORα (PMID:18055760) raises question of how nuclear receptor competition at shared sites is resolved genome-wide
  8. 2016 Medium

    Identification of the NR1H3 p.Arg415Gln mutation in familial MS, with demonstrated loss of heterodimerization and target gene activation, linked LXRα dysfunction to neuroinflammatory disease.

    Evidence Family genetic analysis, heterodimerization assays, reporter gene assays, target gene profiling

    PMID:27253448

    Open questions at the time
    • Independent replication in additional MS families not yet reported
    • Cell-type-specific consequences of R415Q in CNS myeloid or oligodendrocyte lineages not characterized
  9. 2023 Medium

    Direct transcriptional repression of NLRP3 and upstream regulation of AMPK signaling by NR1H3 in cardiomyocytes extended LXRα's anti-inflammatory role to innate immune effector pathways in non-macrophage cells.

    Evidence NR1H3 KO mice in CLP sepsis model with ChIP/luciferase for NLRP3 repression; Western blot for p-AMPK/p-ACC in HL-1 cells with KO epistasis

    PMID:37085126 PMID:37206244

    Open questions at the time
    • Direct mechanism by which NR1H3 activates AMPK phosphorylation is unknown
    • NLRP3 transrepression mechanism (SUMOylation-dependent or independent?) not determined
    • Findings from single labs require independent replication
  10. 2025 Medium

    Cross-species functional studies established NR1H3+ macrophages as a conserved anti-inflammatory population operating through non-canonical NF-κB suppression, while NR1H3-dependent induction of YBX2 revealed a novel downstream anti-ROS effector pathway.

    Evidence Single-cell transcriptomics in tree shrew and human macrophages with NF-κB pathway validation (PMID:41957356); HFD+nephrectomy mouse model with YBX2 KO/OE and NR1H3 agonist RNA-seq (PMID:40505347)

    PMID:40505347 PMID:41957356

    Open questions at the time
    • Whether non-canonical NF-κB suppression uses the same SUMOylation/NCoR mechanism as TLR transrepression is untested
    • YBX2 as direct vs. indirect NR1H3 transcriptional target not confirmed by ChIP
    • Sertoli cell survival role (PMID:41241997) from single study with computational binding

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the identity of the E3 SUMO ligase for LXRα, how transactivation and transrepression programs are partitioned genome-wide in individual cell types, the structural basis of endogenous vs. synthetic ligand selectivity, and whether LXRα AMPK activation is direct or mediated through intermediate kinases.
  • No structural model of full-length LXRα/RXR heterodimer on DNA
  • Genome-wide ChIP-seq comparing transactivation vs. transrepression binding events lacking
  • Phosphorylation sites modulated by PKA/PKC remain unmapped

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 11 GO:0003677 DNA binding 4 GO:0098772 molecular function regulator activity 4 GO:0008289 lipid binding 3
Localization
GO:0005634 nucleus 5
Pathway
R-HSA-1430728 Metabolism 9 R-HSA-162582 Signal Transduction 6 R-HSA-168256 Immune System 5 R-HSA-382551 Transport of small molecules 3
Partners
HNF4ANCOR1NLRP3RORARXRASIRT1
Complex memberships
LXRα/RXR heterodimerNCoR corepressor complex (transrepression)

Evidence

Reading pass · 23 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1995 LXRα (NR1H3) forms a heterodimer with endogenous RXR that binds a distinct LXR response element (LXRE) and mediates 9-cis retinoic acid-dependent transcriptional activation; unlike RXR/RAR heterodimers, the LXRα/RXR interaction shifts RXR from a silent DNA-binding partner to an active ligand-binding subunit responsive to retinoids. Transient transfection/reporter gene assays, EMSA, dominant-negative receptor constructs Genes & development High 7744246
1997 LXRα (NR1H3) is activated by oxysterols (24(S),25-epoxycholesterol and 24(S)-hydroxycholesterol) at physiological concentrations; an LXR response element was identified in the promoter of the cholesterol 7α-hydroxylase gene, defining LXRs as a hormone-signaling pathway responsive to oxysterols. Ligand-binding assays, reporter gene assays, EMSA The Journal of biological chemistry High 9013544
1998 LXRα (NR1H3) knockout mice fail to induce cholesterol 7α-hydroxylase (Cyp7a) transcription upon dietary cholesterol loading and rapidly accumulate hepatic cholesterol, establishing LXRα as the major intracellular cholesterol sensor and feed-forward regulator of bile acid synthesis. LXRα knockout mice, dietary cholesterol challenge, gene expression analysis Cell High 9630215
1998 Transactivation by ligand-activated RLD-1 (LXRα ortholog) is synergistically enhanced by PKA- and PKC-activating agents (PGE2, TPA, 8-bromo-cAMP, forskolin) and blocked by protein kinase inhibitors H-89 and bisindolylmaleimide, indicating that LXRα transcriptional activity can be modulated through phosphorylation-dependent signaling pathways. Stable transfection of chimeric GR-RLD-1 constructs, reporter gene assays, pharmacological kinase inhibitors Biochemical and biophysical research communications Medium 9500983
2000 LXRα (NR1H3) controls cellular cholesterol efflux by transcriptionally inducing ABCA1; retroviral overexpression of LXRα or oxysterol treatment induces ABCA1 mRNA 7–30-fold and stimulates apolipoprotein AI-mediated cholesterol efflux, while dominant-negative LXRα attenuates oxysterol-induced ABCA1 expression. Retroviral overexpression, dominant-negative constructs, cholesterol efflux assays, Tangier disease fibroblasts as genetic controls Proceedings of the National Academy of Sciences of the United States of America High 11035776
2000 LXRα (NR1H3) activates the SREBP-1 lipogenic program; synthetic LXR agonist T0901317 induces coordinate expression of fatty acid biosynthetic genes and raises plasma triglycerides in mice and hamsters, revealing a novel role for LXRα in lipogenesis beyond cholesterol metabolism. In vivo pharmacology in mice and hamsters, cell culture gene expression, complementary KO studies Genes & development High 11090131
2001 LXRα/RXR heterodimers directly regulate apolipoprotein E (apoE) transcription through conserved LXR response elements in macrophage/adipose enhancers ME.1 and ME.2; lipid-inducible apoE expression is abolished in Lxrα−/−Lxrβ−/− double-knockout mice. EMSA, reporter gene assays, LXR single and double knockout mice Proceedings of the National Academy of Sciences of the United States of America High 11149950
2001 PPARα and PPARγ activators induce ABCA1 expression and cholesterol efflux in human macrophages through upregulation of LXRα; this LXRα-mediated ABCA1 induction is absent in Tangier disease macrophages, positioning LXRα downstream of PPAR signaling in reverse cholesterol transport. Primary human macrophage culture, pharmacological PPAR agonists, Tangier disease cell controls, cholesterol efflux assays Nature medicine High 11135616
2005 LXRs (including LXRα/NR1H3) transrepress TLR3-, TLR4-, and TLR9-induced inflammatory genes in macrophages through a p65/IRF3-independent mechanism, cooperating with GR and PPARγ to synergistically suppress distinct subsets of TLR-responsive genes. Macrophage reporter assays, siRNA knockdown, combinatorial nuclear receptor perturbation experiments Cell High 16143103
2007 SIRT1 physically interacts with LXRα (NR1H3), deacetylates a conserved lysine K432 adjacent to the AF2 activation domain, and promotes subsequent ubiquitination; K432 mutation eliminates SIRT1-dependent LXRα activation and reduces expression of LXR target genes including ABCA1 in vivo. Co-immunoprecipitation, mutagenesis of K432, in vivo SIRT1 loss-of-function, Western blot, gene expression Molecular cell High 17936707
2007 Ligand-dependent conjugation of SUMO2/3 to LXRα (NR1H3) targets it to promoters of TLR-responsive inflammatory genes, where it prevents signal-dependent removal of NCoR corepressor complexes required for transcriptional activation; mutagenesis and natural oxysterol studies show that transactivation and SUMOylation-dependent transrepression activities of LXRα are independently regulated. SUMOylation assays, promoter ChIP, mutagenesis, NCoR co-immunoprecipitation, natural vs. synthetic ligand comparisons Molecular cell High 17218271
2007 RORα (NR1F1) and LXRα (NR1H3) mutually suppress each other's transcriptional activity: LXRα suppresses RORα-driven Cyp7b1 promoter activation, and RORα inhibits both constitutive and ligand-dependent LXRα activity; loss of RORα in vivo increases LXRα target gene expression and causes hepatic triglyceride accumulation, while LXRα/β-deficient mice show activation of RORα targets. Reporter gene assays, RORα knockout mice, LXRα/β double-knockout mice, transfection of endogenous target genes Molecular pharmacology High 18055760
2008 LXRα (NR1H3)/RXR heterodimers directly bind an LXR response element in the endoglin (ENG) promoter and mediate LXRα-dependent transcriptional activation of ENG in human trophoblast JAR cells; T0901317 treatment significantly increases ENG mRNA and protein, suggesting a mechanism by which LXRα regulates trophoblast invasion. Transfection/reporter assays, EMSA, RT-PCR, Western blot Biology of reproduction Medium 18276933
2014 NR1H3 (LXRα) promotes hepatocyte differentiation through a reciprocal regulatory network with HNF4α; overexpression of NR1H3 in HepaRG cells accelerates hepatic maturation (CYP activity, urea/albumin secretion, glycogen storage) and the resulting cells rescue lethal fulminant hepatic failure in a mouse model. Transcriptomic screening, overexpression in HepaRG cells, functional hepatocyte assays, in vivo transplantation Journal of hepatology Medium 25073010
2014 In utero malnutrition induces altered DNA methylation of the Lxra 5′ UTR in sperm of F1 male mice, which is transmitted to and maintained in somatic liver cells of F2 offspring, resulting in reduced Lxra expression and altered lipogenic gene expression. Mouse IUGR model, bisulfite sequencing, sperm and liver DNA methylation analysis, gene expression Cell metabolism Medium 24794974
2016 The NR1H3 p.Arg415Gln mutation found in familial multiple sclerosis patients disrupts NR1H3 heterodimerization and transcriptional activation of target genes; mutant NR1H3 alters gene expression profiles, indicating dominant-negative disruption of LXRα-dependent transcriptional regulation as a mechanism in MS pathogenesis. Family genetic analysis, heterodimerization assays, reporter gene assays, protein expression and target gene profiling Neuron Medium 27253448
2023 NR1H3 directly represses NLRP3 inflammasome activity in cardiomyocytes; NR1H3 knockout worsens CLP-induced septic cardiac dysfunction with exacerbated NLRP3-mediated inflammation, oxidative stress, mitochondrial dysfunction, and apoptosis, while T0901317 treatment improves cardiac function; Co-IP, luciferase reporter, and ChIP assays confirmed direct NR1H3–NLRP3 transcriptional repression. NR1H3 knockout mice, CLP sepsis model, T0901317 agonist, Co-IP, luciferase reporter assay, ChIP, RNA-seq Bioengineering & translational medicine Medium 37206244
2023 NR1H3 activation regulates AMPK signaling; T0901317 treatment increases AMPK and ACC phosphorylation in HL-1 cardiomyocytes, and NR1H3 knockout abolishes the protective effect of psoralidin in septic mice, placing NR1H3 upstream of AMPK in the NR1H3/AMPK pathway. NR1H3 knockout mice, CLP model, T0901317 agonist, Western blot for p-AMPK/p-ACC, pharmacological rescue Free radical biology & medicine Medium 37085126
2020 Maternal fructose consumption increases miR-206 expression in offspring rat livers, which post-transcriptionally suppresses Lxra (Nr1h3) expression; pyrosequencing showed no change in Lxra promoter DNA methylation, isolating miR-206-mediated regulation as the mechanism linking maternal diet to reduced hepatic Lxra and decreased serum HDL-C. Rat dietary model, RT-PCR, pyrosequencing (DNA methylation), miRNA expression profiling The Journal of nutritional biochemistry Medium 32388164
2026 NR1H3+ tissue macrophages mediate an evolutionarily conserved anti-inflammatory programme by suppressing the non-canonical NF-κB pathway; functional analyses in tree shrew and human macrophages confirmed NR1H3-dependent suppression of non-canonical NF-κB signaling, and during acute EBV infection NR1H3+ macrophages undergo inflammatory reprogramming and act as a major intercellular signalling hub. Single-cell transcriptomics, cross-species dataset integration, NR1H3 functional assays in macrophages, NF-κB pathway reporter/Western blot Nature communications Medium 41957356
2025 BPS (bisphenol S) directly binds NR1H3 protein (stable docking, −20.64 kcal/mol) and reduces NR1H3 protein levels and transcriptional activity in human Sertoli cells; NR1H3 knockdown impairs Sertoli cell survival, while NR1H3 overexpression partially rescues BPS-induced cytotoxicity, establishing NR1H3 as a critical regulator of Sertoli cell survival targeted by BPS. Pharmacophore mapping, molecular docking, molecular dynamics, MM/GBSA, NR1H3 KD/overexpression, luciferase reporter, Western blot Ecotoxicology and environmental safety Medium 41241997
2025 NR1H3 activation upregulates YBX2, a novel anti-ROS transcription factor/RNA-binding protein, suggesting a negative feedback mechanism on inflammation; NR1H3 agonist treatment induced 28 ROS regulators including YBX2, and YBX2 deficiency increased cellular ROS while overexpression suppressed 27 proinflammatory genes induced by hyperlipidemia+CKD. HFD+5/6 nephrectomy mouse model, NR1H3 agonist treatment, RNA-seq, YBX2 KO and overexpression Redox biology Medium 40505347
2024 LXRα (Nr1h3) functions as an intracellular cholesterol sensor via direct binding of endogenous cholesterol-derived ligands; a dominant-negative mutation that selectively reduces response to endogenous ligands while preserving synthetic agonist activation causes rapid MASH-like pathology (ballooning, inflammation, fibrosis, elevated liver cholesterol) on high-fat/high-cholesterol diet, and re-engagement with synthetic agonist reverses disease. Knock-in dominant-negative mouse model, high-fat/high-cholesterol diet, histology, liver lipid quantification, synthetic agonist rescue bioRxivpreprint Medium

Source papers

Stage 0 corpus · 62 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2010 Biological, clinical and population relevance of 95 loci for blood lipids. Nature 2873 20686565
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2000 Role of LXRs in control of lipogenesis. Genes & development 1399 11090131
1998 Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell 1224 9630215
2009 A census of human transcription factors: function, expression and evolution. Nature reviews. Genetics 1191 19274049
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
1997 Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. The Journal of biological chemistry 1009 9013544
2014 A proteome-scale map of the human interactome network. Cell 977 25416956
2001 PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway. Nature medicine 977 11135616
1995 LXR, a nuclear receptor that defines a distinct retinoid response pathway. Genes & development 923 7744246
2000 Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha. Proceedings of the National Academy of Sciences of the United States of America 857 11035776
2020 A reference map of the human binary protein interactome. Nature 849 32296183
1993 Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma. Nature 798 8510758
2003 Complete sequencing and characterization of 21,243 full-length human cDNAs. Nature genetics 754 14702039
2012 Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Cell 708 22939624
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
1997 Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-alpha in humans: no alteration in adipose tissue of obese and NIDDM patients. Diabetes 606 9231657
2010 An atlas of combinatorial transcriptional regulation in mouse and man. Cell 573 20211142
2008 Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nature genetics 569 19060910
2001 LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. Proceedings of the National Academy of Sciences of the United States of America 536 11149950
2007 SIRT1 deacetylates and positively regulates the nuclear receptor LXR. Molecular cell 529 17936707
2005 Molecular determinants of crosstalk between nuclear receptors and toll-like receptors. Cell 525 16143103
2007 Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma. Molecular cell 474 17218271
2015 Widespread macromolecular interaction perturbations in human genetic disorders. Cell 454 25910212
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2016 Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. Cell 423 26871637
2005 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Genome research 409 16344560
2011 Human atherosclerotic plaque alternative macrophages display low cholesterol handling but high phagocytosis because of distinct activities of the PPARγ and LXRα pathways. Circulation research 334 21350215
2009 Liver X receptor in cholesterol metabolism. The Journal of endocrinology 332 19837721
2014 In utero undernutrition in male mice programs liver lipid metabolism in the second-generation offspring involving altered Lxra DNA methylation. Cell metabolism 151 24794974
2007 Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3). Molecular pharmacology 90 18055760
2016 Nuclear Receptor NR1H3 in Familial Multiple Sclerosis. Neuron 71 27253448
2008 Endoglin (CD105) expression is regulated by the liver X receptor alpha (NR1H3) in human trophoblast cell line JAR. Biology of reproduction 35 18276933
2000 Genomic structure and mapping of human orphan receptor LXR alpha: upregulation of LXRa mRNA during monocyte to macrophage differentiation. Journal of atherosclerosis and thrombosis 32 11480455
2022 Silibinin protects against sepsis and septic myocardial injury in an NR1H3-dependent pathway. Free radical biology & medicine 24 35640818
2020 Maternal fructose consumption down-regulates Lxra expression via miR-206-mediated regulation. The Journal of nutritional biochemistry 21 32388164
2014 Liver X receptors alpha gene (NR1H3) promoter polymorphisms are associated with systemic lupus erythematosus in Koreans. Arthritis research & therapy 17 24886807
2014 Liver X receptor α (LXRα/NR1H3) regulates differentiation of hepatocyte-like cells via reciprocal regulation of HNF4α. Journal of hepatology 17 25073010
2013 Effects of NR1H3 genetic variation on the expression of liver X receptor α and the progression of Alzheimer's disease. PloS one 17 24278306
2022 NR1H3 (LXRα) is associated with pro-inflammatory macrophages, predicts survival and suggests potential therapeutic rationales in diffuse large b-cell lymphoma. Hematological oncology 16 35850118
2023 Activation of NR1H3 attenuates the severity of septic myocardial injury by inhibiting NLRP3 inflammasome. Bioengineering & translational medicine 15 37206244
2016 The association of NR1H3 gene with lipid deposition in the pig. Lipids in health and disease 15 27229308
2023 Activation of NR1H3 signaling pathways by psoralidin attenuates septic myocardial injury. Free radical biology & medicine 13 37085126
2018 Genetic variants regulate NR1H3 expression and contribute to multiple sclerosis risk. Journal of the neurological sciences 13 29801879
2021 The effect of N-Acetyl cysteine on the expression of Fxr (Nr1h4), LXRα (Nr1h3) and Sirt1 genes, oxidative stress, and apoptosis in the liver of rats exposed to different doses of cadmium. Molecular biology reports 12 33772418
1998 Synergistic activation of RLD-1 by agents triggering PKA and PKC dependent signalling. Biochemical and biophysical research communications 12 9500983
2018 ENHO, RXRA, and LXRA polymorphisms and dyslipidaemia, related comorbidities and survival in haemodialysis patients. BMC medical genetics 11 30413149
2023 Low expression of NR1H3 correlates with macrophage infiltration and indicates worse survival in breast cancer. Frontiers in genetics 10 36699456
2019 Expression of NR1H3 in endometrial carcinoma and its effect on the proliferation of Ishikawa cells in vitro. OncoTargets and therapy 5 30705597
2013 Nuclear receptor LXR: a new partner for sodium-dependent phosphate cotransporters. Contributions to nephrology 5 23652550
2024 An across breed, diet and tissue analysis reveals the transcription factor NR1H3 as a key mediator of residual feed intake in beef cattle. BMC genomics 4 38438858
2025 Uremic toxin receptor NR1H3 contributes to hyperlipidemia- and chronic kidney disease-accelerated vascular inflammation, which is partially suppressed by novel YBX2 anti-ROS pathway. Redox biology 3 40505347
2022 Expression of ABCA1 Transporter and LXRA/LXRB Receptors in Placenta of Women with Late Onset Preeclampsia. Journal of clinical medicine 3 36013052
2024 Decreased mRNA expression of NR1H3 and ABCA1 in pulmonary tuberculosis patients from population of Punjab, India. Molecular biology reports 1 38740636
2023 Pharmacogenetic association of the NR1H3 promoter variant with antihypertensive response among patients with hypertension: A longitudinal study. Frontiers in pharmacology 1 36950018
2022 New associations of serum β-carotene, lycopene, and zeaxanthin concentrations with NR1H3, APOB, RDH12, AND CYP genes. Food science & nutrition 1 35282004
2026 Tree shrew immune cell atlas identifies NR1H3⁺ tissue macrophages with conserved anti-inflammatory function. Nature communications 0 41957356
2025 Association between the rs2279238 and rs12221497 of the LXRA gene variants and diabetic retinopathy in the Slovenian cohort. Gene 0 40691909
2025 Bisphenol S disrupts human sertoli cell function through NR1H3 degradation: Mechanistic insights from integrated bulk and single-cell transcriptomics. Ecotoxicology and environmental safety 0 41241997
2023 Contributions of NR1H3 genetic polymorphisms to susceptibility and effects of narrowband UVB phototherapy to nonsegmental vitiligo. Scientific reports 0 36854764