Affinage

PLIN1

Perilipin-1 · UniProt O60240

Length
522 aa
Mass
56.0 kDa
Annotated
2026-04-28
59 papers in source corpus 11 papers cited in narrative 13 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PLIN1 (perilipin-1) is an adipocyte-specific lipid droplet coat protein that serves as the master gatekeeper of triglyceride hydrolysis by integrating hormonal signals with the lipolytic machinery at the droplet surface. Under basal conditions, PLIN1 suppresses lipolysis by sequestering the ATGL co-activator CGI-58/ABHD5; PKA-mediated phosphorylation of PLIN1 releases CGI-58 to activate ATGL-driven triglyceride hydrolysis, and the intrinsically disordered C-terminal domain—including a molecular recognition feature at residues 413–417—is required for CGI-58 binding and full suppression of basal lipolysis (PMID:23408028, PMID:25114292, PMID:40109298). PLIN1 also interacts with FSP27/CIDEC to promote unilocular lipid droplet formation, and its recruitment to the droplet surface depends on seipin (BSCL2); loss of PLIN1 or its mislocalization leads to enhanced lipolysis, smaller multilocular droplets, and—in the case of PLIN1-mutated familial partial lipodystrophy—hypertriglyceridemia driven by impaired VLDL/IDL catabolism (PMID:23399566, PMID:32748596, PMID:38899472). PLIN1 transcription in adipocytes is activated by E2F1, PLAG1, and C/EBPβ, repressed by SMAD3, and negatively regulated by promoter CpG methylation (PMID:31981700, PMID:28860604).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 1998 Medium

    Cloning of human PLIN1 established it as a highly conserved, adipose-tissue-specific gene, providing the molecular foundation for studying its lipid droplet functions.

    Evidence Differential display cloning, Northern blot across 20 human tissues, and FISH mapping to 15q26

    PMID:9521880

    Open questions at the time
    • No functional data on lipolysis or lipid droplet association at this stage
    • Protein localization to lipid droplets not directly demonstrated
  2. 2013 Medium

    The mechanism by which PLIN1 suppresses basal lipolysis was defined: PLIN1 sequesters the ATGL co-activator CGI-58 on the droplet surface, and PKA phosphorylation of PLIN1 releases CGI-58 to activate ATGL, establishing the canonical lipolysis-gating model.

    Evidence Co-immunoprecipitation of PLIN1 with CGI-58 and ATGL in adipocyte and muscle contexts

    PMID:23408028

    Open questions at the time
    • Structural basis of CGI-58–PLIN1 interaction unknown
    • Precise phosphorylation sites mediating release not mapped in this study
  3. 2013 High

    PLIN1 was shown to physically interact with FSP27/CIDEC and cooperate in promoting unilocular lipid droplet formation in adipocytes, revealing a second effector partnership beyond CGI-58.

    Evidence Co-immunoprecipitation with domain mapping (FSP27 aa 120–220 binds PLIN1), lipid droplet size and lipolysis assays in human primary adipocytes

    PMID:23399566

    Open questions at the time
    • PLIN1 domain mediating FSP27 binding not mapped
    • Mechanism by which the PLIN1–FSP27 complex enlarges droplets is unclear
  4. 2014 High

    A C-terminal frameshift mutation (439fs) demonstrated that the C-terminal domain of PLIN1 is essential for full suppression of basal lipolysis, despite retaining CGI-58 binding, linking PLIN1 truncation to familial partial lipodystrophy.

    Evidence Stable expression of WT vs. 439fs PLIN1 in preadipocytes with lipolysis, ABHD5 binding, and droplet size readouts

    PMID:25114292

    Open questions at the time
    • How the C-terminal truncation uncouples CGI-58 binding from lipolysis suppression is mechanistically unresolved
    • Whether other PLIN1 mutations produce similar phenotypes not tested
  5. 2017 High

    Epigenetic regulation of PLIN1 was established: promoter CpG methylation inversely controls PLIN1 expression and thereby basal lipolysis in human adipocytes, providing a mechanism linking obesity-associated epigenetic changes to lipolytic dysregulation.

    Evidence CpG methylation array, methylated vs. unmethylated luciferase reporter, DNMT inhibitor treatment increasing PLIN1 mRNA/protein in human adipocytes

    PMID:28860604

    Open questions at the time
    • Identity of DNA methyltransferases responsible not determined
    • Causal direction in obesity (whether methylation causes or results from altered lipolysis) not resolved
  6. 2019 Medium

    A conserved role for PLIN1 in connecting lipid droplets to the cytoskeleton was uncovered: the C. elegans ortholog MDT-28/PLIN-1 directly binds dynein light chain DLC-1 to mediate LD–microtubule interaction and regulate droplet distribution.

    Evidence Forward genetic screen, yeast two-hybrid and pull-down with domain mapping, fluorescence imaging in C. elegans

    PMID:31624276

    Open questions at the time
    • Whether mammalian PLIN1 similarly binds dynein light chain is untested
    • Functional consequences of disrupted LD distribution on lipolysis not addressed
  7. 2020 Medium

    CRISPR knockout of PLIN1 in 3T3-L1 adipocytes confirmed it as essential for restraining basal lipolysis and maintaining unilocular droplet morphology, and revealed compensatory upregulation of HSL and ATGL.

    Evidence CRISPR/Cas9 KO in 3T3-L1 adipocytes with glycerol release, TG quantification, Oil Red O staining, Western blot, RT-PCR

    PMID:32748596

    Open questions at the time
    • Whether HSL/ATGL upregulation is transcriptional compensation or post-translational is unclear
    • No rescue experiment reported
  8. 2020 Medium

    Transcriptional regulation of PLIN1 was mapped: E2F1, PLAG1, and C/EBPβ activate the PLIN1 core promoter while SMAD3 represses it, placing PLIN1 expression under combinatorial transcription factor control.

    Evidence Promoter deletion and luciferase reporter assays, site-directed mutagenesis, siRNA knockdown, and EMSA in bovine adipocytes

    PMID:31981700

    Open questions at the time
    • Validation in human adipocytes lacking
    • In vivo chromatin occupancy (ChIP) not performed
  9. 2022 Medium

    PLIN1 was shown to function outside adipocytes: overexpression in M1 macrophages increased lipid droplet size and suppressed pro-inflammatory gene expression, establishing PLIN1 as a modulator of macrophage inflammatory polarity through lipid storage.

    Evidence PLIN1 overexpression and siRNA silencing in human macrophages with RT-PCR for TNFA, MMP2, ABCA1, ABCG1; immunohistochemistry of carotid plaques

    PMID:35662076

    Open questions at the time
    • Mechanism linking increased LD size to transcriptional changes in macrophages is unknown
    • Single lab, no in vivo macrophage-specific manipulation
  10. 2024 Medium

    In vivo kinetic studies in PLIN1-mutated familial partial lipodystrophy patients revealed that hypertriglyceridemia results from decreased VLDL/IDL catabolism rather than overproduction, mechanistically linked to reduced circulating LPL mass from diminished adipose stores.

    Evidence Stable isotope tracer lipoprotein kinetic study, plasma LPL mass, and adipose LPL expression in n=6 FPL patients vs. controls

    PMID:38899472

    Open questions at the time
    • Small patient cohort
    • Whether LPL secretion defect is direct or secondary to adipose loss is not resolved
  11. 2025 Medium

    Biophysical characterization revealed the PLIN1 C-terminal domain is an intrinsically disordered region with a molecular recognition feature (EPESE, residues 413–417) that likely mediates CGI-58 binding, explaining how this domain functions as a conformationally flexible interaction hub.

    Evidence Circular dichroism spectroscopy, SDS micelle interaction assay, bioinformatic disorder prediction on mouse PLIN1C

    PMID:40109298

    Open questions at the time
    • MoRF–CGI-58 interaction not validated by mutagenesis
    • No high-resolution structural model of the PLIN1–CGI-58 complex

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the structural basis of the PLIN1–CGI-58 interaction, how PKA phosphorylation conformationally triggers CGI-58 release, whether the dynein light chain interaction is conserved in mammals, and the mechanism by which PLIN1 modulates macrophage inflammatory signaling.
  • No high-resolution structure of PLIN1 or PLIN1–CGI-58 complex
  • Phosphorylation-induced conformational change not directly visualized
  • Mammalian PLIN1–dynein interaction not tested
  • Mechanism of PLIN1-mediated transcriptional effects in macrophages unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0008289 lipid binding 4 GO:0060090 molecular adaptor activity 3 GO:0098772 molecular function regulator activity 3
Localization
GO:0005811 lipid droplet 5 GO:0005829 cytosol 1
Pathway
R-HSA-1430728 Metabolism 4 R-HSA-162582 Signal Transduction 2
Partners
ABHD5BSCL2CIDECPNPLA2

Evidence

Reading pass · 13 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2013 FSP27 (CIDEC) interacts with PLIN1 in human primary adipocytes; the C-terminal domain of FSP27 (aa 120-220) binds PLIN1. Co-expression of both proteins increases average lipid droplet size and promotes unilocular adipocyte formation without additively reducing lipolysis beyond individual effects. Co-immunoprecipitation, co-localization by fluorescence microscopy, domain mapping (truncation constructs), triglyceride content and glycerol release assays in human primary adipocytes Biochemical and biophysical research communications High 23399566
2013 In adipocytes, PLIN1 regulates lipolysis by sequestering CGI-58 (ABHD5), an activator of ATGL; upon PKA-mediated phosphorylation of PLIN1, CGI-58 is released to fully activate ATGL and initiate triglyceride hydrolysis. Co-immunoprecipitation of PLIN1 with CGI-58 and ATGL in rat soleus (referenced as established adipocyte mechanism) and contrasted with skeletal muscle PLIN proteins American journal of physiology. Regulatory, integrative and comparative physiology Medium 23408028
2014 A heterozygous frameshift mutation at the carboxy-terminus of PLIN1 (439fs) produces a mutant protein that binds and stabilizes ABHD5 (CGI-58) expression but fails to inhibit basal lipolysis as effectively as wild-type PLIN1, and is associated with smaller lipid droplets in stably transfected preadipocytes, demonstrating that the C-terminal domain of PLIN1 is required for full suppression of basal lipolysis. Stable transfection of preadipocytes with frameshift mutant vs. WT PLIN1, lipolysis assay (glycerol release), ABHD5 binding/expression analysis, lipid droplet size measurement Diabetes High 25114292
1998 Human PLIN1 encodes a 522-amino-acid protein with 79% identity to rat perilipin; Northern blot showed adipose-tissue-specific expression among 20 adult human tissues; chromosomal location mapped to 15q26. Differential display cloning, Northern blot, fluorescence in situ hybridization (FISH) Genomics Medium 9521880
2017 The PLIN1 gene promoter is subject to DNA methylation in human adipocytes; CpG methylation of the PLIN1 promoter is inversely correlated with PLIN1 mRNA expression and basal lipolysis in obese women. Methylated PLIN1 promoter reporter constructs show decreased activity in hMSC-derived adipocytes, and treatment with a DNA methyltransferase inhibitor increases PLIN1 mRNA and protein levels. CpG methylation array, reporter gene (luciferase) assay with methylated vs. unmethylated PLIN1 promoter construct, DNMT inhibitor treatment, correlation analysis with glycerol-release lipolysis assay Scientific reports High 28860604
2019 In C. elegans, the PLIN1 ortholog MDT-28/PLIN-1 mediates interaction between lipid droplets and microtubules via direct binding to the dynein light chain DLC-1; yeast two-hybrid and pull-down assays mapped the DLC-1-binding regions to amino acids 1-210 and 275-415 of MDT-28/PLIN-1. Fluorescence imaging confirmed that MDT-28/PLIN-1 mediates LD-microtubule contact, regulating LD distribution. Forward genetic screen, yeast two-hybrid, pull-down assay, fluorescence imaging in C. elegans Scientific reports Medium 31624276
2020 PLIN1 knockout in 3T3-L1 adipocytes (via CRISPR/Cas9) enhances basal lipolysis, as shown by increased glycerol release and decreased triglyceride content, accompanied by upregulation of HSL and ATGL mRNA and protein. Lipid droplet morphology shifts from unilocular to smaller, multiple droplets. PPARγ and FSP27 expression was unchanged. CRISPR/Cas9 knockout in 3T3-L1 adipocytes, glycerol/TG enzymatic assay, Oil Red O staining, Western blot, RT-PCR Sheng wu gong cheng xue bao = Chinese journal of biotechnology Medium 32748596
2020 In bovine adipocytes, the PLIN1 core promoter region (-209/-17 bp) is activated by transcription factors E2F1, PLAG1, and C/EBPβ, and repressed by SMAD3, as demonstrated by promoter deletion assays, luciferase reporter assays with mutated binding sites, siRNA knockdown, and EMSA. Promoter deletion constructs, luciferase reporter assay, site-directed mutagenesis, siRNA knockdown, EMSA Genomics Medium 31981700
2022 PLIN1 overexpression in M1 macrophages increases lipid droplet size and reduces expression of TNFA, MMP2, ABCA1, and ABCG1; PLIN1 silencing in M2 macrophages has opposite effects on LD size and gene expression, establishing PLIN1 as a regulator of macrophage inflammatory polarity through lipid storage modulation. PLIN1 overexpression and siRNA silencing in cultured human macrophages, immunohistochemistry of carotid endarterectomy plaques, quantitative RT-PCR Journal of atherosclerosis and thrombosis Medium 35662076
2024 Hypertriglyceridemia in PLIN1-related familial partial lipodystrophy results from markedly decreased catabolism of VLDL and IDL (reduced indirect fractional catabolic rates of VLDL-apoB100 and IDL-apoB100), not from increased VLDL production. Plasma LPL mass was significantly lower in patients with PLIN1-mutated FPL than controls, despite similar LPL protein expression in adipose tissue, indicating impaired LPL availability due to reduced adipose mass. In vivo lipoprotein kinetic study (stable isotope tracer), plasma LPL mass measurement, LPL mRNA and protein expression in adipose tissue biopsy Arteriosclerosis, thrombosis, and vascular biology Medium 38899472
2025 The C-terminal domain of mouse PLIN1 (mPLIN1C) behaves as an intrinsically disordered region (IDR) with coil-like or pre-molten globule character; circular dichroism spectroscopy shows predominance of disordered secondary structure. Interaction with SDS micelles induces a conformational transition, and the EPESE sequence (residues 413-417) was identified as a potential molecular recognition feature (MoRF) for partner-molecule binding (including CGI-58). Circular dichroism spectroscopy, bioinformatic disorder prediction, SDS micelle interaction assay Biochemistry and biophysics reports Medium 40109298
2025 Seipin (BSCL2) is required for recruiting PLIN1 to the lipid droplet surface in human adipocytes; without seipin, lipid droplet biogenesis still occurs but PLIN1 fails to localize to droplets, resulting in enhanced lipolysis, ceramide accumulation, and adipocyte de-differentiation into a progenitor-like state. This identifies seipin as an upstream regulator of PLIN1 LD recruitment that enforces adipocyte identity. BSCL2 knockout in human adipocyte progenitor cells, live-cell imaging of PLIN1 localization, lipolysis assay, lipid/ceramide quantification, in vivo xenograft differentiation bioRxivpreprint High
2024 During differentiation of 3T3 pre-adipocytes into adipocytes, PLIN1—a high-affinity LD protein—becomes predominantly recruited to lipid droplets and displaces other ER proteins through steric exclusion, demonstrating lateral protein-protein exclusion as a mechanism shaping the LD proteome. Ex vivo quantitative LD partitioning assay, fluorescence imaging during 3T3-L1 adipocyte differentiation, competition assay between LD-targeting proteins bioRxivpreprint Medium

Source papers

Stage 0 corpus · 59 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2013 FSP27 and PLIN1 interaction promotes the formation of large lipid droplets in human adipocytes. Biochemical and biophysical research communications 112 23399566
2004 Genetic variation at the perilipin (PLIN) locus is associated with obesity-related phenotypes in White women. Clinical genetics 82 15355432
2013 Skeletal muscle PLIN proteins, ATGL and CGI-58, interactions at rest and following stimulated contraction. American journal of physiology. Regulatory, integrative and comparative physiology 76 23408028
2014 Clinical and molecular characterization of a novel PLIN1 frameshift mutation identified in patients with familial partial lipodystrophy. Diabetes 64 25114292
2012 Perilipin family (PLIN) proteins in human skeletal muscle: the effect of sex, obesity, and endurance training. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 61 22667335
2018 A Key Gene, PLIN1, Can Affect Porcine Intramuscular Fat Content Based on Transcriptome Analysis. Genes 56 29617344
2005 Intragenic linkage disequilibrium structure of the human perilipin gene (PLIN) and haplotype association with increased obesity risk in a multiethnic Asian population. Journal of molecular medicine (Berlin, Germany) 56 15770500
2020 Function and characterization of the promoter region of perilipin 1 (PLIN1): Roles of E2F1, PLAG1, C/EBPβ, and SMAD3 in bovine adipocytes. Genomics 36 31981700
2020 Plin-amiR, a pre-microRNA-based technology for controlling herbivorous insect pests. Plant biotechnology journal 35 32012433
2020 Overexpression of PLIN1 Promotes Lipid Metabolism in Bovine Adipocytes. Animals : an open access journal from MDPI 35 33105676
2008 Effects of perilipin (PLIN) gene variation on metabolic syndrome risk and weight loss in obese children and adolescents. The Journal of clinical endocrinology and metabolism 33 18812483
2019 Diagnostic Challenge in PLIN1-Associated Familial Partial Lipodystrophy. The Journal of clinical endocrinology and metabolism 31 31504636
1998 Isolation and chromosomal mapping of the human homolog of perilipin (PLIN), a rat adipose tissue-specific gene, by differential display method. Genomics 31 9521880
2020 Long non-coding RNA ARAP1-AS1 accelerates cell proliferation and migration in breast cancer through miR-2110/HDAC2/PLIN1 axis. Bioscience reports 29 32110804
2011 Subcellular localization of skeletal muscle lipid droplets and PLIN family proteins OXPAT and ADRP at rest and following contraction in rat soleus muscle. American journal of physiology. Regulatory, integrative and comparative physiology 28 22012700
2011 Preliminary findings on the role of PLIN1 polymorphisms on body composition and energy metabolism response to energy restriction in obese women. The British journal of nutrition 27 21392418
2009 Endurance exercise training effects on body fatness, VO2max, HDL-C subfractions, and glucose tolerance are influenced by a PLIN haplotype in older Caucasians. Journal of applied physiology (Bethesda, Md. : 1985) 24 19850727
2018 PLIN1 Haploinsufficiency Is Not Associated With Lipodystrophy. The Journal of clinical endocrinology and metabolism 23 30020498
2017 UCP2 and PLIN1 Expression Affects the Resting Metabolic Rate and Weight Loss on Obese Patients. Obesity surgery 23 27376365
2022 PLIN1 Haploinsufficiency Causes a Favorable Metabolic Profile. The Journal of clinical endocrinology and metabolism 19 35235652
2021 A Study of the Regulatory Mechanism of the CB1/PPARγ2/PLIN1/HSL Pathway for Fat Metabolism in Cattle. Frontiers in genetics 19 34017353
2017 Epigenetic Regulation of PLIN 1 in Obese Women and its Relation to Lipolysis. Scientific reports 19 28860604
2004 Polymorphisms in PLIN and hypertension combined with obesity and lipid profiles in Han Chinese. Obesity research 19 15601966
2022 Lipid Droplet Protein PLIN1 Regulates Inflammatory Polarity in Human Macrophages and is Involved in Atherosclerotic Plaque Development by Promoting Stable Lipid Storage. Journal of atherosclerosis and thrombosis 18 35662076
2019 MDT-28/PLIN-1 mediates lipid droplet-microtubule interaction via DLC-1 in Caenorhabditis elegans. Scientific reports 18 31624276
2020 Polymorphism of the PLIN1 gene and its association with body measures and ultrasound carcass traits in Qinchuan beef cattle. Genome 13 32615043
2015 A maternal high fat diet has long-lasting effects on skeletal muscle lipid and PLIN protein content in rat offspring at young adulthood. Lipids 13 25552350
2013 Association between three genetic variants of the Perilipin Gene (PLIN) and glucose metabolism: results from a replication study among Chinese adults and a meta-analysis. Endocrine research 13 23517113
2020 RXRα Positively Regulates Expression of the Chicken PLIN1 Gene in a PPARγ-Independent Manner and Promotes Adipogenesis. Frontiers in cell and developmental biology 12 32478078
2012 Evaluation of the ENPP1 and PLIN single nucleotide polymorphisms with type 2 diabetes in a Taiwanese population: evidence for replication and gene-gene interaction. Journal of investigative medicine : the official publication of the American Federation for Clinical Research 12 23111648
2016 Adipose tissue depot specific differences of PLIN protein content in endurance trained rats. Adipocyte 11 27386161
2009 Variation in the perilipin gene (PLIN) affects glucose and lipid metabolism in non-Hispanic white women with and without polycystic ovary syndrome. Diabetes research and clinical practice 9 19782423
2008 Polymorphisms in perilipin gene (PLIN) are not associated with obesity and weight variation in people with high risk of type 2 diabetes. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 9 18777456
2008 No association of PLIN polymorphisms with hemorrhagic and ischemic stroke. Stroke 8 18174481
2008 Cloning, chromosome mapping and expression pattern of porcine PLIN and M6PRBP1 genes. Genetics, selection, evolution : GSE 8 18298936
2014 A functional variant in the exon 5 of PLIN1 reduces risk of central obesity by possible regulation of lipid storage. Biochemical and biophysical research communications 7 25529448
2021 Polymorphism PLIN1 11482 G>A interacts with dietary intake to modulate anthropometric measures and lipid profile in adults with normal-weight obesity syndrome. The British journal of nutrition 6 34725012
2019 DNA methylation of the PLIN1 promoter downregulates expression in chicken lines. Archives animal breeding 6 31807648
2016 An Improved PCR-RFLP Assay for the Detection of a Polymorphism rs2289487 of PLIN1 Gene. Journal of clinical laboratory analysis 6 27611592
2024 Hypertriglyceridemia Results From an Impaired Catabolism of Triglyceride-Rich Lipoproteins in PLIN1-Related Lipodystrophy. Arteriosclerosis, thrombosis, and vascular biology 5 38899472
2022 Effects of PLIN1 Gene Knockout on the Proliferation, Apoptosis, Differentiation and Lipolysis of Chicken Preadipocytes. Animals : an open access journal from MDPI 5 36611701
2021 The Utility of Perilipin in Liposarcomas: PLIN1 Differentiates Round Cell Liposarcoma From Other Round Cell Sarcomas. Applied immunohistochemistry & molecular morphology : AIMM 5 32205741
2019 Childhood Obesity Risk in Relationship to Perilipin 1 (PLIN1) Gene Regulation by Circulating microRNAs. Omics : a journal of integrative biology 5 31851864
2017 Influence of expression of UCP3, PLIN1 and PPARG2 on the oxidation of substrates after hypocaloric dietary intervention. Clinical nutrition (Edinburgh, Scotland) 5 28651828
2023 Transcriptomics and Selection Pressure Analysis Reveals the Influence Mechanism of PLIN1 Protein on the Development of Small Size in Min Pigs. International journal of molecular sciences 4 36835359
2022 The effect of the PLIN1 gene on the metabolism and mitochondria of porcine skeletal muscle satellite cells. Genes & genomics 4 35438463
2024 Correlational analysis of PLIN1 with inflammation in diabetic foot ulcer wounds. Diabetes research and clinical practice 3 38453058
2023 Polymorphisms of PLIN1 and MOGAT1 genes and their association with feed efficiency in Hu sheep. Gene 3 38081333
2020 [CRISPR/Cas9 knockout plin1 enhances lipolysis in 3T3-L1 adipocytes]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology 3 32748596
2025 PLIN1 suppresses glioma progression through regulating lipid metabolism. Cell death & disease 2 39870645
2025 Runx1 activates the transformation of adipocytes into cancer-associated adipocytes by downregulating Plin1. Experimental cell research 2 40280321
2024 Variants in GHRL, RETN, and PLIN1 are associated with obesity, diabetes, and metabolic syndrome, and influence food consumption in adults with obesity. Nutrition research (New York, N.Y.) 2 39826191
2025 Transcriptome Analysis Reveals the Molecular Mechanism of PLIN1 in Goose Hierarchical and Pre-Hierarchical Follicle Granulosa Cells. Animals : an open access journal from MDPI 1 39858284
2024 Antioxidant treatment attenuates age-related placenta GLUT-1 and PLIN-2 downregulation. Placenta 1 39765049
2019 Manduca sexta Perilipin 1B: A new PLIN1 isoform linked to fat storage prior to pupation. Insect biochemistry and molecular biology 1 31055048
2016 An Improved PCR-RFLP Assay for the Detection of a Polymorphism of PLIN1 Gene. Clinical laboratory 1 27468581
2025 The C-terminal end of PLIN1 displays structural disorder. Biochemistry and biophysics reports 0 40109298
2024 A PLIN1 polymorphism is associated with fat production in male emus. Poultry science 0 39541877
2015 [Effect of Interaction between PLIN Gene Polymorphisms and Open Lifestyle Intervention on Weight-loss in Chinese Han Adults]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 0 26725391