Affinage

PLIN1

Perilipin-1 · UniProt O60240

Length
522 aa
Mass
56.0 kDa
Annotated
2026-06-10
60 papers in source corpus 15 papers cited in narrative 17 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PLIN1 (perilipin-1) is an adipose-specific lipid droplet coat protein that controls triglyceride storage and mobilization by gating lipase access to the droplet core (PMID:9521880, PMID:32748596). CRISPR knockout in adipocytes elevates lipolysis and upregulates HSL and ATGL while leaving PPARγ and FSP27 unchanged, establishing that PLIN1 suppresses basal lipolysis by limiting lipase access rather than through these factors (PMID:32748596). PLIN1 physically interacts with CGI-58 (ABHD5), an ATGL activator, and stabilizes its expression; this interaction is mediated by the protein's C-terminal region, which behaves as an intrinsically disordered domain containing a candidate molecular-recognition motif (EPESE, residues 413-417) for CGI-58 binding (PMID:23408028, PMID:25114292, PMID:40109298). PLIN1 also co-localizes and physically interacts with FSP27/CIDEC via the CIDEC C-terminus, and their co-expression enlarges lipid droplets and promotes unilocular adipocyte morphology (PMID:23399566). Recruitment of PLIN1 to the lipid droplet surface requires seipin (BSCL2) and reflects PLIN1's high affinity for the droplet surface, where it laterally displaces lower-affinity proteins and remodels the droplet proteome; loss of this recruitment enhances lipolysis and drives adipocyte de-differentiation. C-terminal frameshift mutations that extend the protein impair suppression of basal lipolysis and cause familial partial lipodystrophy, with affected patients showing impaired VLDL/IDL catabolism and reduced plasma LPL availability (PMID:25114292, PMID:38899472). PLIN1 transcription is controlled by promoter methylation and by transcription factors including E2F1, PLAG1, C/EBPβ and SMAD3 (PMID:28860604, PMID:31981700).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 1998 Medium

    Establishing PLIN1 as a distinct human gene with adipose-restricted expression set the foundation for studying it as an adipocyte-specific lipid droplet regulator.

    Evidence cDNA cloning, Northern blot across 20 tissues, and FISH mapping to 15q26

    PMID:9521880

    Open questions at the time
    • No functional mechanism defined at this stage
    • Protein localization to lipid droplets not directly demonstrated here
  2. 2013 Medium

    Identifying a direct PLIN1-FSP27/CIDEC interaction explained how PLIN1 contributes to lipid droplet enlargement and unilocular adipocyte morphology, mapping the interaction to the CIDEC C-terminus.

    Evidence Reciprocal Co-IP, co-localization, and co-expression with LD-size and lipolysis readouts in human primary adipocytes

    PMID:23399566

    Open questions at the time
    • PLIN1 region mediating the interaction not mapped
    • Stoichiometry and structural basis unknown
  3. 2013 Medium

    Co-IP testing of the perilipin-CGI-58 model placed PLIN1's regulation of lipolysis in the framework of phosphorylation-triggered CGI-58 release to activate ATGL.

    Evidence Reciprocal Co-IP in rat soleus muscle at rest and after tetanic stimulation, referencing the adipocyte PLIN1-CGI-58 model

    PMID:23408028

    Open questions at the time
    • PLIN1 absent in skeletal muscle, so the adipocyte interaction is inferred by analogy
    • Direct phosphorylation-dependent release not measured for PLIN1 itself here
  4. 2014 Medium

    Functional dissection of a C-terminal frameshift mutant showed that ABHD5/CGI-58 binding can be retained yet basal lipolysis suppression still lost, separating CGI-58 stabilization from lipolytic control and linking C-terminal integrity to lipodystrophy.

    Evidence Stable transfection of preadipocytes with 439fs mutant, Western blot for ABHD5, LD-size and glycerol-release assays

    PMID:25114292

    Open questions at the time
    • Molecular mechanism by which the extended C-terminus impairs lipolysis control unresolved
    • Single cell-model system
  5. 2017 Medium

    Demonstrating that promoter methylation represses PLIN1 and correlates with basal lipolysis added an epigenetic layer of control over PLIN1 abundance in obesity.

    Evidence CpG methylation array, methylated/unmethylated luciferase reporter assays, DNMT inhibitor treatment, glycerol release in human MSC-derived adipocytes

    PMID:28860604

    Open questions at the time
    • Specific methyltransferases and signals driving methylation not identified
    • Correlational link to lipolysis rate
  6. 2020 Medium

    Mapping E2F1, PLAG1, C/EBPβ and SMAD3 to the PLIN1 core promoter defined the transcriptional circuitry controlling PLIN1 expression and downstream lipid metabolism.

    Evidence Promoter deletion/luciferase assays, site-directed mutagenesis, EMSA, siRNA knockdown in bovine adipocytes

    PMID:31981700

    Open questions at the time
    • Activator vs repressor roles of individual factors not fully resolved
    • Bovine system; human conservation not tested
  7. 2022 Medium

    CRISPR knockout in adipocytes established causally that PLIN1 suppresses basal lipolysis by limiting lipase access, independently of PPARγ and FSP27.

    Evidence CRISPR/Cas9 KO in 3T3-L1, Oil Red O, glycerol/triglyceride assays, Western blot and RT-PCR for HSL/ATGL/PPARγ/FSP27

    PMID:32748596

    Open questions at the time
    • Mechanism of lipase exclusion at the molecular level not resolved
    • Stimulated lipolysis arm not dissected here
  8. 2022 Medium

    Gain/loss-of-function in macrophages extended PLIN1 function beyond adipocytes, linking PLIN1-coated large lipid droplets to an anti-inflammatory phenotype.

    Evidence Overexpression and siRNA in human macrophages, RT-PCR for inflammatory and cholesterol-transport genes, carotid plaque IHC

    PMID:35662076

    Open questions at the time
    • Mechanism connecting LD size to inflammatory gene expression unknown
    • Causality in vivo not established
  9. 2024 Medium

    In vivo kinetic study in lipodystrophy patients traced PLIN1 dysfunction to systemic consequences, showing impaired VLDL/IDL catabolism and reduced plasma LPL availability.

    Evidence Stable-isotope lipoprotein kinetics, plasma LPL mass, adipose LPL mRNA/protein in PLIN1-mutated patients

    PMID:38899472

    Open questions at the time
    • Mechanistic link between adipocyte PLIN1 loss and reduced LPL release not defined
    • Small patient cohort
  10. 2025 Medium

    Identifying seipin as required for PLIN1 recruitment to the droplet surface placed PLIN1 loading as a quality-control checkpoint enforcing adipocyte identity.

    Evidence BSCL2 KO in human adipocyte progenitors, differentiation, lipolysis and ceramide assays, live imaging, xenografts (preprint)

    Open questions at the time
    • Direct seipin-PLIN1 interaction vs indirect recruitment not distinguished
    • Preprint, single lab
  11. 2025 Low

    Biophysical characterization defined the PLIN1 C-terminus as an intrinsically disordered region with a candidate CGI-58 binding motif, providing a structural basis for its co-regulator interactions.

    Evidence Circular dichroism, SDS-micelle conformational assays, disorder prediction and MoRF analysis on recombinant mouse C-terminal fragment

    PMID:40109298

    Open questions at the time
    • No functional mutagenesis validating the EPESE motif
    • Isolated fragment, not full-length protein in cells

Open questions

Synthesis pass · forward-looking unresolved questions
  • How PLIN1 phosphorylation, CGI-58 release, and the disordered C-terminus mechanistically coordinate the switch from basal lipolysis suppression to stimulated lipolysis remains to be reconstituted.
  • No structural model of PLIN1 on the droplet surface bound to partners
  • Lipase-exclusion mechanism uncharacterized at molecular resolution

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 3 GO:0008289 lipid binding 1
Localization
GO:0005811 lipid droplet 3
Pathway
R-HSA-1430728 Metabolism 2
Partners
ABHD5BSCL2CIDECDLC-1

Evidence

Reading pass · 17 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2013 FSP27 (CIDEC) co-localizes and physically interacts with PLIN1 in human primary adipocytes; the C-terminal domain of FSP27 (aa 120-220) mediates this interaction. Co-expression of both proteins increases average lipid droplet size and promotes formation of unilocular adipocytes, beyond the effect of either protein alone. Co-immunoprecipitation, co-localization imaging, exogenous co-expression in human primary adipocytes, glycerol release assay, triglyceride content measurement Biochemical and biophysical research communications Medium 23399566
2013 In skeletal muscle, PLIN1 is absent; in adipocytes, PLIN1 is thought to regulate lipolysis by directly interacting with CGI-58, an activator of ATGL. Upon lipolytic stimulation, PLIN1 phosphorylation releases CGI-58 to fully activate ATGL and initiate triglyceride breakdown (model confirmed by analogy from adipocyte literature, tested indirectly via skeletal muscle PLIN2/3/5 interactions). Co-immunoprecipitation in isolated rat soleus muscle at rest and following tetanic stimulation American journal of physiology. Regulatory, integrative and comparative physiology Medium 23408028
2014 A novel heterozygous frameshift mutation at the carboxy-terminus (439fs) of PLIN1 produces a mutant protein at lower expression levels than wild-type; in stably transfected preadipocytes, the mutant is associated with smaller lipid droplets. Unlike previously reported frameshift mutants (398fs, 404fs), the 439fs variant retains the ability to bind and stabilize ABHD5 (CGI-58) expression but still fails to inhibit basal lipolysis as effectively as wild-type PLIN1. Stable transfection of preadipocytes, western blot for protein expression and ABHD5, lipid droplet size measurement, glycerol release lipolysis assay Diabetes Medium 25114292
1998 The human PLIN1 gene encodes a 522 amino acid protein with 79% amino acid identity to rat perilipin; it is expressed specifically in adipose tissue among 20 human adult tissues and maps to chromosome 15q26. Differential display cDNA cloning, Northern blot, fluorescence in situ hybridization (FISH) Genomics Medium 9521880
2019 In C. elegans, the PLIN1 ortholog MDT-28/PLIN-1 physically binds to DLC-1 (dynein light chain) through its amino acids 1-210 and 275-415, mediating the interaction between lipid droplets and microtubules and thereby regulating lipid droplet distribution within the cell. Forward genetic screen, yeast two-hybrid, pull-down assays, fluorescence imaging of DHS-3::GFP-labeled lipid droplets Scientific reports Medium 31624276
2017 Promoter methylation of the PLIN1 gene is higher in adipocytes from obese women compared to never-obese women, inversely correlates with PLIN1 mRNA expression and with basal lipolysis rate. Methylation of the PLIN1 promoter directly reduces reporter gene activity in human mesenchymal stem cells differentiated into adipocytes; treatment with a DNA methyltransferase inhibitor increases PLIN1 mRNA and protein levels. CpG methylation array, correlation analysis, reporter gene (luciferase) assay with methylated vs. unmethylated promoter constructs, DNA methyltransferase inhibitor treatment, glycerol release lipolysis assay Scientific reports Medium 28860604
2020 In bovine adipocytes, E2F1, PLAG1, C/EBPβ, and SMAD3 bind to specific sites within the core promoter region (-209/-17 bp) of the PLIN1 gene and act as transcriptional activators or repressors. Knockdown of PLIN1 affects the ability of these transcription factors to regulate lipid metabolism. Promoter deletion/luciferase reporter assays, site-directed mutagenesis, siRNA knockdown, electrophoretic mobility shift assay (EMSA) Genomics Medium 31981700
2022 PLIN1 knockout in 3T3-L1 adipocytes via CRISPR/Cas9 increases lipolysis (elevated glycerol release, decreased triglyceride content), reduces unilocular lipid droplet size, and upregulates HSL and ATGL mRNA and protein expression. PPARγ and FSP27 expression are unchanged, indicating PLIN1 regulates lipolysis by limiting lipase access to lipid droplets independently of these factors. CRISPR/Cas9 knockout, Oil Red O staining, enzymatic glycerol and triglyceride assays, Western blot, RT-PCR Sheng wu gong cheng xue bao = Chinese journal of biotechnology Medium 32748596
2022 PLIN1 overexpression in M1 macrophages increases lipid droplet size and reduces expression of pro-inflammatory genes (TNFA, MMP2) and cholesterol transporters (ABCA1, ABCG1). Conversely, PLIN1 silencing in M2 macrophages has opposite effects on LD size and inflammatory gene expression. PLIN1 expression on large lipid droplets is associated with an anti-inflammatory macrophage phenotype. PLIN1 overexpression and siRNA knockdown in cultured human macrophages, immunohistochemistry of carotid endarterectomy tissue, RT-PCR for inflammatory markers Journal of atherosclerosis and thrombosis Medium 35662076
2024 Hypertriglyceridemia in PLIN1-related familial partial lipodystrophy results from markedly impaired catabolism of VLDL and IDL (reduced indirect fractional catabolic rates), with normal VLDL-apoB100 production. Plasma LPL mass is significantly reduced in PLIN1-mutated patients despite normal LPL protein expression in adipose tissue, suggesting impaired LPL release/availability as a downstream consequence of PLIN1 dysfunction. In vivo lipoprotein kinetic study (stable isotope tracer), plasma LPL mass measurement, LPL mRNA and protein expression in adipose tissue biopsies Arteriosclerosis, thrombosis, and vascular biology Medium 38899472
2025 The C-terminal end of mouse PLIN1 (mPLIN1C) behaves as an intrinsically disordered region (IDR) of the coil-like or pre-molten globule type. Interaction with SDS micelles induces a conformational transition toward a pre-molten globule state. Molecular recognition feature (MoRF) analysis identifies the EPESE sequence (residues 413-417) as a potential binding site for partner molecules including CGI-58. Circular dichroism spectroscopy, SDS micelle interaction assays, bioinformatic disorder prediction, MoRF analysis Biochemistry and biophysics reports Low 40109298
2019 In chicken, RXRα activates transcription of the PLIN1 gene in a PPARγ-independent manner by binding to a specific site in the PLIN1 promoter region (-774/-785 bp). RXRα overexpression promotes preadipocyte differentiation with concomitant increase in PLIN1 transcripts. Reporter gene assays, promoter deletion analysis, EMSA, RXRα overexpression in immortalized chicken preadipocyte line (ICP1) Frontiers in cell and developmental biology Low 32478078
2025 Seipin (BSCL2) is required for recruiting PLIN1 to the lipid droplet surface in human adipocytes but is dispensable for lipid droplet biogenesis itself. Loss of seipin-dependent PLIN1 recruitment leads to enhanced lipolysis, ceramide accumulation, and de-differentiation of adipocytes into a progenitor-like state. This identifies PLIN1 recruitment as a seipin-dependent quality-control checkpoint enforcing adipocyte identity. BSCL2 knockout in human adipocyte progenitor cells, in vitro and in vivo differentiation assays, lipolysis measurement, ceramide quantification, live-cell imaging, xenograft experiments bioRxivpreprint Medium
2024 During differentiation of 3T3-L1 preadipocytes into adipocytes, PLIN1 becomes a high-affinity lipid droplet protein that is extensively recruited to the LD surface and displaces lower-affinity ER proteins via lateral steric exclusion, remodeling the LD proteome. Ex vivo ER-to-LD partitioning assay, fluorescence microscopy, quantitative protein localization during adipocyte differentiation bioRxivpreprint Low
2022 PLIN1 knockout and overexpression in porcine skeletal muscle satellite cells both enhance anti-apoptotic ability and accelerate metabolic activity, but at the cost of mitochondrial structural damage, reduced mitochondrial number, and decreased mitochondrial function, indicating PLIN1 stable expression is required for normal mitochondrial homeostasis in these cells. CRISPR/Cas9 knockout, adenoviral overexpression, flow cytometry (apoptosis, cell cycle), western blot for mitochondrial proteins, electron microscopy Genes & genomics Low 35438463
2025 Runx1 transcription factor promotes the transformation of adipocytes into cancer-associated adipocytes (CAAs) by downregulating Plin1 expression. Overexpression of Plin1 in adipocytes inhibits the Runx1-driven transition to CAAs and reduces enhancement of breast cancer cell migration and invasion. Co-culture system of mature adipocytes and breast cancer cells, RNA sequencing, Runx1 overexpression/knockdown in 3T3-L1 preadipocytes, Plin1 overexpression rescue experiments, migration/invasion assays Experimental cell research Low 40280321
2025 In glioma cells, the PI3K/AKT signaling axis negatively regulates PLIN1 levels; pharmacological inhibition of PI3K/AKT activity increases PLIN1 expression, which in turn suppresses cell growth and invasion and increases lipid accumulation with upregulation of lipid biosynthesis genes and downregulation of lipolysis genes. PI3K/AKT inhibitor treatment, PLIN1 overexpression, RNA-seq, cell proliferation and invasion assays Cell death & disease Low 39870645

Source papers

Stage 0 corpus · 60 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2013 FSP27 and PLIN1 interaction promotes the formation of large lipid droplets in human adipocytes. Biochemical and biophysical research communications 113 23399566
2004 Genetic variation at the perilipin (PLIN) locus is associated with obesity-related phenotypes in White women. Clinical genetics 83 15355432
2013 Skeletal muscle PLIN proteins, ATGL and CGI-58, interactions at rest and following stimulated contraction. American journal of physiology. Regulatory, integrative and comparative physiology 76 23408028
2014 Clinical and molecular characterization of a novel PLIN1 frameshift mutation identified in patients with familial partial lipodystrophy. Diabetes 64 25114292
2012 Perilipin family (PLIN) proteins in human skeletal muscle: the effect of sex, obesity, and endurance training. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 61 22667335
2018 A Key Gene, PLIN1, Can Affect Porcine Intramuscular Fat Content Based on Transcriptome Analysis. Genes 57 29617344
2005 Intragenic linkage disequilibrium structure of the human perilipin gene (PLIN) and haplotype association with increased obesity risk in a multiethnic Asian population. Journal of molecular medicine (Berlin, Germany) 56 15770500
2020 Overexpression of PLIN1 Promotes Lipid Metabolism in Bovine Adipocytes. Animals : an open access journal from MDPI 38 33105676
2020 Function and characterization of the promoter region of perilipin 1 (PLIN1): Roles of E2F1, PLAG1, C/EBPβ, and SMAD3 in bovine adipocytes. Genomics 37 31981700
2020 Plin-amiR, a pre-microRNA-based technology for controlling herbivorous insect pests. Plant biotechnology journal 36 32012433
2008 Effects of perilipin (PLIN) gene variation on metabolic syndrome risk and weight loss in obese children and adolescents. The Journal of clinical endocrinology and metabolism 33 18812483
2019 Diagnostic Challenge in PLIN1-Associated Familial Partial Lipodystrophy. The Journal of clinical endocrinology and metabolism 31 31504636
1998 Isolation and chromosomal mapping of the human homolog of perilipin (PLIN), a rat adipose tissue-specific gene, by differential display method. Genomics 31 9521880
2020 Long non-coding RNA ARAP1-AS1 accelerates cell proliferation and migration in breast cancer through miR-2110/HDAC2/PLIN1 axis. Bioscience reports 29 32110804
2011 Subcellular localization of skeletal muscle lipid droplets and PLIN family proteins OXPAT and ADRP at rest and following contraction in rat soleus muscle. American journal of physiology. Regulatory, integrative and comparative physiology 28 22012700
2011 Preliminary findings on the role of PLIN1 polymorphisms on body composition and energy metabolism response to energy restriction in obese women. The British journal of nutrition 27 21392418
2009 Endurance exercise training effects on body fatness, VO2max, HDL-C subfractions, and glucose tolerance are influenced by a PLIN haplotype in older Caucasians. Journal of applied physiology (Bethesda, Md. : 1985) 24 19850727
2018 PLIN1 Haploinsufficiency Is Not Associated With Lipodystrophy. The Journal of clinical endocrinology and metabolism 23 30020498
2017 UCP2 and PLIN1 Expression Affects the Resting Metabolic Rate and Weight Loss on Obese Patients. Obesity surgery 23 27376365
2022 Lipid Droplet Protein PLIN1 Regulates Inflammatory Polarity in Human Macrophages and is Involved in Atherosclerotic Plaque Development by Promoting Stable Lipid Storage. Journal of atherosclerosis and thrombosis 21 35662076
2021 A Study of the Regulatory Mechanism of the CB1/PPARγ2/PLIN1/HSL Pathway for Fat Metabolism in Cattle. Frontiers in genetics 20 34017353
2017 Epigenetic Regulation of PLIN 1 in Obese Women and its Relation to Lipolysis. Scientific reports 20 28860604
2022 PLIN1 Haploinsufficiency Causes a Favorable Metabolic Profile. The Journal of clinical endocrinology and metabolism 19 35235652
2019 MDT-28/PLIN-1 mediates lipid droplet-microtubule interaction via DLC-1 in Caenorhabditis elegans. Scientific reports 19 31624276
2004 Polymorphisms in PLIN and hypertension combined with obesity and lipid profiles in Han Chinese. Obesity research 19 15601966
2020 Polymorphism of the PLIN1 gene and its association with body measures and ultrasound carcass traits in Qinchuan beef cattle. Genome 14 32615043
2015 A maternal high fat diet has long-lasting effects on skeletal muscle lipid and PLIN protein content in rat offspring at young adulthood. Lipids 14 25552350
2013 Association between three genetic variants of the Perilipin Gene (PLIN) and glucose metabolism: results from a replication study among Chinese adults and a meta-analysis. Endocrine research 13 23517113
2020 RXRα Positively Regulates Expression of the Chicken PLIN1 Gene in a PPARγ-Independent Manner and Promotes Adipogenesis. Frontiers in cell and developmental biology 12 32478078
2012 Evaluation of the ENPP1 and PLIN single nucleotide polymorphisms with type 2 diabetes in a Taiwanese population: evidence for replication and gene-gene interaction. Journal of investigative medicine : the official publication of the American Federation for Clinical Research 12 23111648
2016 Adipose tissue depot specific differences of PLIN protein content in endurance trained rats. Adipocyte 11 27386161
2009 Variation in the perilipin gene (PLIN) affects glucose and lipid metabolism in non-Hispanic white women with and without polycystic ovary syndrome. Diabetes research and clinical practice 9 19782423
2008 Polymorphisms in perilipin gene (PLIN) are not associated with obesity and weight variation in people with high risk of type 2 diabetes. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 9 18777456
2022 Effects of PLIN1 Gene Knockout on the Proliferation, Apoptosis, Differentiation and Lipolysis of Chicken Preadipocytes. Animals : an open access journal from MDPI 8 36611701
2008 No association of PLIN polymorphisms with hemorrhagic and ischemic stroke. Stroke 8 18174481
2008 Cloning, chromosome mapping and expression pattern of porcine PLIN and M6PRBP1 genes. Genetics, selection, evolution : GSE 8 18298936
2014 A functional variant in the exon 5 of PLIN1 reduces risk of central obesity by possible regulation of lipid storage. Biochemical and biophysical research communications 7 25529448
2021 Polymorphism PLIN1 11482 G>A interacts with dietary intake to modulate anthropometric measures and lipid profile in adults with normal-weight obesity syndrome. The British journal of nutrition 6 34725012
2019 DNA methylation of the PLIN1 promoter downregulates expression in chicken lines. Archives animal breeding 6 31807648
2017 Influence of expression of UCP3, PLIN1 and PPARG2 on the oxidation of substrates after hypocaloric dietary intervention. Clinical nutrition (Edinburgh, Scotland) 6 28651828
2016 An Improved PCR-RFLP Assay for the Detection of a Polymorphism rs2289487 of PLIN1 Gene. Journal of clinical laboratory analysis 6 27611592
2024 Hypertriglyceridemia Results From an Impaired Catabolism of Triglyceride-Rich Lipoproteins in PLIN1-Related Lipodystrophy. Arteriosclerosis, thrombosis, and vascular biology 5 38899472
2021 The Utility of Perilipin in Liposarcomas: PLIN1 Differentiates Round Cell Liposarcoma From Other Round Cell Sarcomas. Applied immunohistochemistry & molecular morphology : AIMM 5 32205741
2019 Childhood Obesity Risk in Relationship to Perilipin 1 (PLIN1) Gene Regulation by Circulating microRNAs. Omics : a journal of integrative biology 5 31851864
2024 Correlational analysis of PLIN1 with inflammation in diabetic foot ulcer wounds. Diabetes research and clinical practice 4 38453058
2023 Transcriptomics and Selection Pressure Analysis Reveals the Influence Mechanism of PLIN1 Protein on the Development of Small Size in Min Pigs. International journal of molecular sciences 4 36835359
2023 Polymorphisms of PLIN1 and MOGAT1 genes and their association with feed efficiency in Hu sheep. Gene 4 38081333
2022 The effect of the PLIN1 gene on the metabolism and mitochondria of porcine skeletal muscle satellite cells. Genes & genomics 4 35438463
2025 PLIN1 suppresses glioma progression through regulating lipid metabolism. Cell death & disease 3 39870645
2020 [CRISPR/Cas9 knockout plin1 enhances lipolysis in 3T3-L1 adipocytes]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology 3 32748596
2025 Runx1 activates the transformation of adipocytes into cancer-associated adipocytes by downregulating Plin1. Experimental cell research 2 40280321
2024 Antioxidant treatment attenuates age-related placenta GLUT-1 and PLIN-2 downregulation. Placenta 2 39765049
2024 Variants in GHRL, RETN, and PLIN1 are associated with obesity, diabetes, and metabolic syndrome, and influence food consumption in adults with obesity. Nutrition research (New York, N.Y.) 2 39826191
2025 Transcriptome Analysis Reveals the Molecular Mechanism of PLIN1 in Goose Hierarchical and Pre-Hierarchical Follicle Granulosa Cells. Animals : an open access journal from MDPI 1 39858284
2024 A PLIN1 polymorphism is associated with fat production in male emus. Poultry science 1 39541877
2019 Manduca sexta Perilipin 1B: A new PLIN1 isoform linked to fat storage prior to pupation. Insect biochemistry and molecular biology 1 31055048
2016 An Improved PCR-RFLP Assay for the Detection of a Polymorphism of PLIN1 Gene. Clinical laboratory 1 27468581
2026 PLIN1 associates with lipid droplets and mediates lipolysis in the perirenal brown adipose tissue of yak calves. Frontiers in veterinary science 0 42052336
2025 The C-terminal end of PLIN1 displays structural disorder. Biochemistry and biophysics reports 0 40109298
2015 [Effect of Interaction between PLIN Gene Polymorphisms and Open Lifestyle Intervention on Weight-loss in Chinese Han Adults]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 0 26725391

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