Affinage

BATF2

Basic leucine zipper transcriptional factor ATF-like 2 · UniProt Q8N1L9

Length
274 aa
Mass
29.4 kDa
Annotated
2026-06-09
90 papers in source corpus 33 papers cited in narrative 33 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/7 claims corpus-supported (86%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

BATF2 (SARI) is an interferon-inducible basic leucine zipper transcription factor that functions as a tumor suppressor and an immune regulator by reprogramming AP-1-dependent and interferon-dependent gene expression (PMID:19074269, PMID:25957166). Its founding activity is antagonism of AP-1: BATF2 binds c-Jun through its leucine zipper domain, blocking AP-1 DNA binding and transactivation, repressing AP-1 targets such as CCN1, and triggering cancer-cell-selective apoptosis (PMID:19074269, PMID:20531301). In innate immune cells BATF2 partners with transcriptional and signaling factors to shape inflammatory output — it complexes with IRF1 to co-regulate M1 macrophage genes (Tnf, Ccl5, Il12b, Nos2), with NF-κB p50/p65 to drive IL-12p40 and CD8+ T cell activation, and with JUN to amplify pro-inflammatory CCL5 signaling, while preventing c-JUN–ATF2 complex formation to restrain Il23a and IL-17-mediated immunopathology (PMID:25957166, PMID:28808017, PMID:28356392, PMID:36824275). Its induction in macrophages is interferon-driven, requiring TRIF and type I IFN signaling, and human loss-of-function (p.Gln19*) dysregulates interferon-stimulated genes (PMID:37724373, PMID:36672163); in astrocytes BATF2 directly occupies IRF1 regulatory regions by ChIP-seq to prevent overactive IFN signaling and protect against CNS autoimmunity (PMID:40057949). Beyond transcriptional partnerships, BATF2 acts post-translationally — it directly binds ceruloplasmin and drives its degradation to suppress the HIF-1α/VEGF angiogenic axis, binds and stabilizes p53 to inhibit ERK signaling, and when phosphorylated at Ser227 promotes STING oligomerization to favor a type-I-IFN-dependent anti-tumor response (PMID:27353863, PMID:32650804, PMID:41457098). As a sequence-specific factor BATF2 binds defined genomic motifs and represses cell-cycle genes (cyclin D1, CDK2, p27) in astrocytes (PMID:40945729, PMID:26977016). BATF2 protein abundance is itself controlled: glucocorticoid receptor binds the SARI promoter to activate transcription, while m6A modification by METTL3/METTL14 silences BATF2 mRNA in gastric and tongue cancers, and a CRM1-dependent NES drives nuclear export followed by ubiquitin-mediated degradation in colorectal cancer (PMID:26808579, PMID:32650804, PMID:37151195, PMID:35949109).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 2008 High

    Established BATF2's founding molecular activity — that an IFN-inducible bZIP factor antagonizes AP-1 — answering how it could act as a tumor suppressor.

    Evidence Co-IP of leucine-zipper interaction with c-Jun, AP-1 reporter assays, antisense knockdown and overexpression in cancer versus normal cells

    PMID:19074269

    Open questions at the time
    • Did not define direct genomic targets of BATF2 itself
    • Mechanism of cancer-cell-selective apoptosis unresolved
  2. 2010 High

    Connected AP-1 antagonism to a specific target promoter and tumor phenotype, showing BATF2 suppresses CCN1 and anchorage-independent growth.

    Evidence Adenoviral overexpression, CCN1 promoter luciferase and AP-1 binding assays, c-Jun-overexpressing fibroblast epistasis

    PMID:20531301

    Open questions at the time
    • Whether CCN1 repression is direct or via AP-1 sequestration not separated
  3. 2012 Medium

    Showed loss of BATF2 promotes EMT and metastasis via GSK-3β/β-catenin, framing it as a metastasis suppressor.

    Evidence Knockdown in carcinoma cells, xenograft lymph node metastasis model, EMT marker Western blotting

    PMID:23049725

    Open questions at the time
    • No direct evidence BATF2 regulates GSK-3β/β-catenin components transcriptionally
    • Single lab
  4. 2015 High

    Identified IRF1 as a transcriptional partner, establishing BATF2 as a co-regulator of the M1 macrophage inflammatory program.

    Evidence Co-IP, siRNA knockdown, expression profiling and promoter motif enrichment in macrophages

    PMID:25957166

    Open questions at the time
    • DNA-binding contribution of BATF2 versus IRF1 at target promoters not dissected
  5. 2016 High

    Revealed a non-transcriptional mechanism — direct binding and degradation of ceruloplasmin — linking BATF2 to suppression of the HIF-1α/VEGF angiogenic axis.

    Evidence Co-IP/MS, HUVEC angiogenesis assays, antibody arrays, AOM/DSS tumor model in SARI-deficient mice

    PMID:27353863

    Open questions at the time
    • Protease responsible for ceruloplasmin degradation not identified
    • How a nuclear bZIP factor reaches ceruloplasmin unclear
  6. 2016 High

    Defined upstream transcriptional control by glucocorticoid receptor, explaining how steroid signaling induces BATF2 to suppress growth.

    Evidence EMSA and ChIP showing GR binding to the SARI promoter ER9 element, reporter assays, siRNA knockdown with dexamethasone treatment

    PMID:26808579

    Open questions at the time
    • Whether GR induction of BATF2 occurs outside B lymphoma cells not tested
  7. 2016 Medium

    Provided the first direct genomic binding map, showing BATF2 recognizes a centromeric satellite-associated motif.

    Evidence Stable transfection in HeLa, ChIP-seq and motif analysis

    PMID:26977016

    Open questions at the time
    • Functional consequence of satellite DNA transcription unclear
    • Single-method study
  8. 2017 High

    Established two distinct immune partnerships: NF-κB-dependent promotion of IL-12p40 anti-tumor immunity and JUN-dependent restraint of pathogenic IL-23/IL-17.

    Evidence Co-IP with p50/p65 and with c-JUN, Batf2-/- mice, macrophage stimulation, tumor and T. cruzi infection models

    PMID:28356392 PMID:28808017

    Open questions at the time
    • How BATF2 switches between activating (NF-κB) and repressive (JUN/ATF2) modes not defined
  9. 2020 Medium

    Identified p53 stabilization as a mechanism of ERK inhibition and revealed m6A as a post-transcriptional silencing layer in gastric cancer.

    Evidence Co-IP, p53 stability and p-ERK Western blotting, m6A modification assays in gastric cancer

    PMID:32650804

    Open questions at the time
    • Direct vs. indirect link between p53 binding and ERK suppression unresolved
    • Single lab
  10. 2023 High

    Defined nuclear export and degradation as the route to BATF2 inactivation in cancer, identifying CRM1 as the export receptor.

    Evidence Co-IP/LC-MS proteomics, NES point mutation, CRM1 knockdown, immunofluorescence, xenografts

    PMID:37151195

    Open questions at the time
    • E3 ligase mediating cytoplasmic BATF2 degradation not identified
  11. 2023 High

    Connected human BATF2 loss-of-function to dysregulated interferon-stimulated gene control, establishing a physiological brake on innate immunity.

    Evidence Whole-exome sequencing of p.Gln19* patients, CRISPR-Cas9 BATF2-/- human monocytic lines with stimulation assays

    PMID:36672163

    Open questions at the time
    • Clinical disease spectrum of the mutation not fully delineated
    • Direct ISG targets in human cells not mapped
  12. 2023 High

    Showed interferon-pathway dependence of BATF2 induction (TRIF/type I IFN, not MyD88) and a JUN-CCL5 axis amplifying inflammation in hematopoietic cells.

    Evidence TRIF/MyD88/IFN-deficient macrophages, Co-IP of BATF2-JUN, Batf2 KO infection models with CCL5 blockade and rescue

    PMID:36824275 PMID:37724373

    Open questions at the time
    • How interferon signaling drives BATF2 transcription mechanistically not shown
  13. 2025 High

    Provided direct genomic evidence that BATF2 occupies cell-cycle and IRF1 regulatory regions in astrocytes, unifying its growth-suppressive and IFN-restraining roles.

    Evidence ChIP-seq in astrocytes, BATF2 KO astrocytes and Batf2-/- EAE mice, proliferation marker Western blotting, MS lesion immunofluorescence

    PMID:40057949 PMID:40945729

    Open questions at the time
    • Whether BATF2 binds these loci directly or via partner factors not resolved
    • Cofactors at IRF1 regulatory regions unidentified
  14. 2025 Medium

    Linked a specific phosphorylation event (Ser227) to STING oligomerization and a metabolism-dependent type-I IFN anti-tumor response.

    Evidence Phospho-site mutagenesis, STING oligomerization assays, metabolic profiling, syngeneic and carcinogen-induced HNSCC Batf2-/- models

    PMID:41457098

    Open questions at the time
    • Kinase responsible for Ser227 phosphorylation unknown
    • Single study

Open questions

Synthesis pass · forward-looking unresolved questions
  • How BATF2 selects between transcriptional activation, AP-1 sequestration, and direct cytoplasmic protein degradation in different cell types, and which signals govern its nuclear-cytoplasmic partitioning, remains unresolved.
  • No structural model of BATF2 DNA or partner binding
  • Kinase/E3 ligase machinery acting on BATF2 incompletely defined
  • Direct genome-wide targets across cell types only partially mapped

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 5 GO:0098772 molecular function regulator activity 3 GO:0003677 DNA binding 2
Localization
GO:0005634 nucleus 3 GO:0005829 cytosol 1
Pathway
R-HSA-168256 Immune System 5 R-HSA-1643685 Disease 4 R-HSA-162582 Signal Transduction 3 R-HSA-74160 Gene expression (Transcription) 3 R-HSA-1640170 Cell Cycle 1
Partners
ATF3IRF1JUNNFKB1RELASINHCAFSTAT1TP53

Evidence

Reading pass · 33 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2008 BATF2/SARI is an IFN-beta-inducible gene that interacts with c-Jun via its leucine zipper domain, inhibiting DNA binding of the AP-1 complex and consequently suppressing AP-1-dependent gene expression; overexpression induces apoptosis in cancer cells but not normal cells. Co-immunoprecipitation (leucine zipper interaction with c-Jun), AP-1 reporter assays, antisense knockdown, overexpression in cancer vs. normal cells Proceedings of the National Academy of Sciences of the United States of America High 19074269
2010 BATF2/SARI inhibits AP-1 transactivation by interacting with c-Jun and directly suppresses CCN1 promoter activity; SARI overexpression reduces CCN1-promoter AP-1 binding and inhibits anchorage-independent growth and tumor cell invasion. Adenoviral overexpression (Ad.SARI), promoter-activity luciferase assays, AP-1 binding assays, stable c-Jun-overexpressing rat embryo fibroblast epistasis model Oncogene High 20531301
2015 BATF2 forms a complex with IRF1; Co-IP demonstrated this association, and IRF1 knockdown down-regulated IFN-γ- or LPS-activated host-protective genes (Tnf, Ccl5, Il12b, Nos2), indicating BATF2/IRF1 co-regulation of M1 macrophage inflammatory gene expression. Co-immunoprecipitation, siRNA knockdown, expression profiling, promoter motif enrichment analysis Journal of immunology (Baltimore, Md. : 1950) High 25957166
2015 BATF2 overexpression inhibits HGF/MET signaling in colorectal cancer cells, suppressing proliferation, migration, and invasion; MET inhibitors combined with IFN-β produced synergistic cytotoxicity in vitro and in vivo. Overexpression in cultured CRC cells, xenograft tumor models, in vitro/in vivo combination treatment assays Clinical cancer research : an official journal of the American Association for Cancer Research Medium 25762344
2016 BATF2/SARI directly interacts with ceruloplasmin (Cp) and induces its protease degradation, thereby inhibiting the HIF-1α/VEGF axis and suppressing tumor angiogenesis. Co-IP/PAGE/mass spectrometry, HUVEC angiogenesis assays, antibody arrays, in vivo AOM/DSS tumor model in SARI-deficient mice Nature communications High 27353863
2013 BATF2/SARI expression is necessary for mda-7/IL-24 anti-tumor effects; MDA-7/IL-24 induces SARI through p38 MAPK phosphorylation, and inhibition of p38 MAPK blocks SARI induction; secreted MDA-7/IL-24 induces its own expression via an autocrine loop involving SARI. SARI antisense inhibition, adenoviral overexpression, p38 MAPK inhibitor experiments, recombinant MDA-7/IL-24 stimulation, receptor binding studies Cancer research Medium 24282278
2017 BATF2 interacts with NF-κB p50/p65 subunits and promotes IL-12 p40 expression in macrophages; BATF2-deficient macrophages produce significantly less IL-12 p40 upon TLR ligand stimulation, reducing CD8+ T cell activation within tumors. Co-immunoprecipitation (BATF2 with p50/p65), Batf2-/- mouse model, in vitro macrophage stimulation assays, subcutaneous tumor model Proceedings of the National Academy of Sciences of the United States of America High 28808017
2017 BATF2 interacts with c-JUN and prevents c-JUN–ATF-2 complex formation in innate immune cells, thereby inhibiting Il23a expression and suppressing IL-17-mediated immunopathology during T. cruzi infection. Batf2-/- mouse infection model, co-immunoprecipitation (BATF2/c-JUN), cytokine measurement, T cell transfer experiments The Journal of experimental medicine High 28356392
2016 Glucocorticoid receptor (GR) directly binds the ER9 element in the SARI promoter region, activating SARI transcription; SARI upregulation is necessary for dexamethasone-mediated growth suppression and AP-1 inhibition in B lymphoma cells. EMSA, ChIP assays, reporter assays, SARI siRNA knockdown, in vitro and in vivo dexamethasone treatment Cancer letters High 26808579
2020 BATF2 binds p53 protein and enhances its stability, thereby inhibiting ERK phosphorylation in gastric cancer cells; additionally, METTL3-mediated m6A modification of BATF2 mRNA represses BATF2 expression in gastric cancer. Co-immunoprecipitation (BATF2-p53), Western blotting for p53 stability and p-ERK levels, m6A modification assays, in vitro and in vivo functional experiments Molecular cancer Medium 32650804
2019 BATF2 suppresses the STAT1/MCP-1/CCR2 axis in colon cancer cells: SARI deficiency increases p-STAT1 and STAT1 expression, promotes MCP-1 secretion, and enhances tumor-associated macrophage infiltration during colitis-associated cancer. SARI-deficient mouse model, bone marrow reconstitution, Western blotting for p-STAT1, functional tumor macrophage infiltration assays Journal of cellular and molecular medicine Medium 31578820
2019 BATF2 targets PAI-1 (plasminogen activator inhibitor-1), as shown by Co-IP and luciferase assays; BATF2 induction by calycosin suppresses TGF-β-induced EMT and cell migration via the Wnt and PI3K/Akt signaling pathways in CRC cells. Co-immunoprecipitation, luciferase reporter assays, Transwell migration assays, Western blotting Journal of experimental & clinical cancer research : CR Medium 31174572
2019 BATF2 overexpression suppresses Wnt/β-catenin signaling and reverses multidrug resistance in gastric cancer cells; knockdown of β-catenin mimics BATF2 effects, and restoration of Wnt/β-catenin activity reverses BATF2-mediated drug sensitization. Overexpression/knockdown systems, Wnt/β-catenin reporter (TOP/FOP FLASH implied), Western blotting, MTT assay, flow cytometry In vitro cellular & developmental biology. Animal Medium 31140101
2012 Loss of SARI/BATF2 expression initiates epithelial-mesenchymal transition (EMT) in lung adenocarcinoma, characterized by repression of E-cadherin and upregulation of vimentin; SARI regulates EMT through the GSK-3β/β-catenin signaling pathway. SARI knockdown in human carcinoma cells, xenograft mouse model for lymph node metastasis, Western blotting for EMT markers and pathway components PloS one Medium 23049725
2018 BATF2 and STAT1 expression are mutually dependent in trophoblast cells; BATF2 silencing increases invasion, and both BATF2 and STAT1 regulate phospho-JUN expression, jointly mediating IFN-γ-induced inhibition of HTR-8/SVneo trophoblast invasion. siRNA knockdown of BATF2 and STAT1, Transwell invasion assays, NGS expression profiling, Western blotting Cell adhesion & migration Medium 29394132
2023 BATF2 nuclear export is mediated through a functional nuclear export sequence (NES) that binds CRM1 (exportin-1); cytoplasmic BATF2 is subsequently targeted for ubiquitin-mediated degradation and enhances CRC growth via AP-1/cyclin D1/pRb signaling. Mutation of NES or CRM1 knockdown retards export and suppresses tumor growth. Co-IP, quantitative label-free LC-MS/MS proteomics, Western blotting, immunofluorescence, point mutation of NES, siRNA knockdown of CRM1, xenograft nude mice Clinical and translational medicine High 37151195
2023 BATF2 forms a complex with JUN in hematopoietic stem cells (HSCs) to amplify pro-inflammatory signaling including CCL5; CCL5 receptor blockade phenocopies Batf2 KO myeloid differentiation defects, and recombinant CCL5 rescues IFN-γ-induced myeloid differentiation in Batf2 KO mice. Co-IP (BATF2-JUN complex), Batf2 KO mouse model during chronic infection, CCL5 receptor blockade/recombinant CCL5 rescue experiments iScience High 36824275
2023 Induction of BATF2 expression in macrophages by Klebsiella pneumoniae requires TRIF and type I interferon signaling but not MyD88; BATF2 markedly enhances macrophage pro-inflammatory cytokine responses and contributes to early host defense against pulmonary infection. TRIF-/-, MyD88-/-, type I IFN signaling-deficient macrophage experiments in vitro; Batf2-/- mouse Kp infection model American journal of physiology. Lung cellular and molecular physiology High 37724373
2025 BATF2 binds regulatory regions of cell cycle genes (CDKR1B/p27, CDK2, cyclin D1) in astrocytes as determined by ChIP-seq; BATF2 loss increases expression of these targets and increases proliferation markers (Ki67, phospho-histone H3), establishing BATF2 as a cell cycle suppressor in astrocytes. Chromatin immunoprecipitation sequencing (ChIP-seq), BATF2 KO astrocytes, Western blotting for proliferation markers, patient-derived glioblastoma sample analysis The Journal of biological chemistry High 40945729
2025 In astrocytes, BATF2 binds and prevents overexpression of IRF1 and IRF1 targets (e.g., caspase-1) as shown by ChIP-seq; Batf2-/- mice show exacerbated CNS autoimmune disease severity with increased astrocyte IRF1 and caspase-1 expression. ChIP-seq, Batf2-/- mouse EAE model, immunofluorescence in MS patient lesions, Western blotting Cell reports High 40057949
2025 BATF2 phosphorylation at serine 227 promotes oligomerization of STING; BATF2 deficiency or high glutamine levels result in higher oxygen consumption rates and metabolic profiles unfavorable for type I interferon production; cancer cell-specific BATF2 expression promotes a type-I IFN-dependent anti-tumor response. Phosphorylation site mutational analysis, STING oligomerization assays, metabolic profiling, syngeneic orthotopic and carcinogen-induced HNSCC models with Batf2-/- mice Nature communications Medium 41457098
2021 BATF2 inhibits SDF-1α/CXCL12 expression intracellularly, reducing its loading into extracellular vesicles; BATF2-containing EVs inhibit MDSC chemotaxis in vitro, and blocking SDF-1α/CXCR4 signaling phenocopies BATF2 overexpression in reducing MDSC recruitment to glioblastoma. BATF2 overexpressing glioma cell EV isolation, in vitro MDSC chemotaxis assays, AMD3100 (CXCR4 antagonist) blockade, Western blotting for SDF-1α Oncogene Medium 33452462
2021 BATF2/SARI induces cancer-specific cell death in OSCC by inhibiting GLI1 expression through induction of endoplasmic reticulum (ER) stress; an ER stress inhibitor reverses SARI-mediated tumor growth inhibition in vivo. Adenoviral SARI overexpression (Ad.SARI), confocal microscopy for ER stress markers, ER stress inhibitor rescue, xenograft nude mouse model Life sciences Medium 34774620
2024 BATF2 interacts with SINHCAF and together they regulate TTC23 transcription; this regulation modulates macrophage quantity and anti-bacterial/antigen-presenting function during Mycobacterium tuberculosis infection through the Wnt/β-catenin pathway. Co-immunoprecipitation (BATF2-SINHCAF), TTC23 knockdown/overexpression, Wnt/β-catenin pathway inhibition, macrophage functional assays International journal of biological macromolecules Medium 39672395
2025 BATF2 transcriptionally regulates RGS2 in CD8+ T cells; BATF2 KO mice show increased effector CD8+ T cells and reduced exhausted T cells; luciferase reporter assays confirmed BATF2 as a transcriptional activator of RGS2, promoting T cell exhaustion through inhibition of CXCL13 secretion. Luciferase reporter assays for RGS2 promoter, BATF2-/- and RGS2-/- mouse tumor models, single-cell transcriptomics, CD8+ T cell co-culture cytotoxicity assays Molecular cancer Medium 40442751
2022 METTL14-mediated m6A modification of BATF2 mRNA suppresses BATF2 expression in tongue squamous cell carcinoma; BATF2 suppresses tumor angiogenesis by inhibiting VEGFA expression. m6A methylation assays, METTL14 knockdown/overexpression, Western blotting for VEGFA, angiogenesis assays in TSCC cell lines Cell cycle (Georgetown, Tex.) Medium 35949109
2024 BATF2 inhibits ABCG2 drug transporter expression and promotes PTEN stability, suppressing AKT phosphorylation, reducing nuclear β-catenin, and decreasing stem cell markers (CD44, SOX2, NANOG) to reduce chemoresistance in gastric cancer. BATF2 overexpression/KD in GC cells and organoids, Western blotting for PTEN/AKT/β-catenin pathway, ABCG2 expression assays, in vivo subcutaneous tumor model, scRNA-seq Theranostics Medium 39629124
2023 Loss-of-function homozygous BATF2 mutation (p.Gln19*) in humans causes dysregulation of interferon-stimulated genes and elevated innate immune responses; CRISPR-Cas9 BATF2-/- human monocytic cell lines recapitulate elevated responses to innate immune stimuli. Whole-exome sequencing, transcriptome analysis, CRISPR-Cas9 BATF2-/- human monocytic cell lines, stimulation assays Cells High 36672163
2025 BATF2 stabilizes ATF3 by inhibiting its ubiquitination; BATF2 overexpression impairs mitochondrial redox homeostasis in nucleus pulposus cells, promoting apoptosis and ECM catabolism; ATF3 knockdown reverses BATF2-induced mitochondrial dysfunction. Ubiquitination assays for ATF3, BATF2 overexpression/KD in nucleus pulposus cells, mitochondrial function assays, ATF3 siRNA rescue, in vivo disc degeneration model International immunopharmacology Medium 40267724
2016 BATF2 overexpression drives transcription of centromeric type II satellite DNA; ChIP-seq identified a specific DNA binding motif (TTCCATT[CT]GATTCCATTC[AG]AT) primarily distributed among chromosome centromere regions. Stable BATF2 transfection in HeLa cells, ChIP-sequencing, bioinformatics motif analysis, satellite DNA transcription assays Anticancer research Medium 26977016
2021 BATF2 promotes Th1 and Treg cell differentiation but suppresses Th17 cell activation in CD4+ T cells; BATF2 mRNA is increased under Th1 and Treg polarization conditions but decreased under Th17 polarization. siRNA knockdown of BATF2 in human CD4+ T cells, cytokine polarization conditions, flow cytometry for T cell subsets Biochemical and biophysical research communications Medium 33740622
2024 ABBV-744 (BD2-selective BET inhibitor) reduces BATF2 and IRF4 expression and suppresses JAK-STAT signaling in LPS-stimulated microglia; gene knockdown of BATF2 confirmed BATF2 is required for the BATF2-IRF4-STAT1/3/5 pathway regulation of microglial inflammation. RNA-seq, BATF2/IRF4 siRNA knockdown, Western blotting for STAT1/3/5, in vitro BV-2 and primary microglia models, in vivo mouse LPS model Acta pharmacologica Sinica Medium 38862817
2023 BATF2 inhibits PD-L1 expression in cancer cells by inhibiting the PI3K-AKT pathway, with ZEB2 playing an important role in this process; BATF2 promotes CD8+ T cell infiltration and activation in non-small cell lung cancer. BATF2 KO mice, human xenograft mice, RT-qPCR, Western blotting, bioinformatics analysis The Journal of biological chemistry Medium 37777155

Source papers

Stage 0 corpus · 90 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2015 Batf2/Irf1 induces inflammatory responses in classically activated macrophages, lipopolysaccharides, and mycobacterial infection. Journal of immunology (Baltimore, Md. : 1950) 89 25957166
2016 SARI inhibits angiogenesis and tumour growth of human colon cancer through directly targeting ceruloplasmin. Nature communications 85 27353863
2020 m6A modification-mediated BATF2 acts as a tumor suppressor in gastric cancer through inhibition of ERK signaling. Molecular cancer 83 32650804
2008 Cloning and characterization of SARI (suppressor of AP-1, regulated by IFN). Proceedings of the National Academy of Sciences of the United States of America 81 19074269
2019 Calycosin suppresses TGF-β-induced epithelial-to-mesenchymal transition and migration by upregulating BATF2 to target PAI-1 via the Wnt and PI3K/Akt signaling pathways in colorectal cancer cells. Journal of experimental & clinical cancer research : CR 48 31174572
2013 Novel mechanism of MDA-7/IL-24 cancer-specific apoptosis through SARI induction. Cancer research 46 24282278
2010 Inhibition of AP-1 by SARI negatively regulates transformation progression mediated by CCN1. Oncogene 45 20531301
2017 Antitumor effect of Batf2 through IL-12 p40 up-regulation in tumor-associated macrophages. Proceedings of the National Academy of Sciences of the United States of America 44 28808017
2015 Epidemiology of severe acute respiratory illness (SARI) among adults and children aged ≥5 years in a high HIV-prevalence setting, 2009-2012. PloS one 44 25706880
2015 BATF2 Deficiency Promotes Progression in Human Colorectal Cancer via Activation of HGF/MET Signaling: A Potential Rationale for Combining MET Inhibitors with IFNs. Clinical cancer research : an official journal of the American Association for Cancer Research 41 25762344
2019 Targeted demethylation of the SARI promotor impairs colon tumour growth. Cancer letters 40 30771439
2012 The function of SARI in modulating epithelial-mesenchymal transition and lung adenocarcinoma metastasis. PloS one 40 23049725
2017 BATF2 inhibits immunopathological Th17 responses by suppressing Il23a expression during Trypanosoma cruzi infection. The Journal of experimental medicine 38 28356392
2021 Sarilumab in adults hospitalised with moderate-to-severe COVID-19 pneumonia (CORIMUNO-SARI-1): An open-label randomised controlled trial. The Lancet. Rheumatology 37 34812424
2015 Targeting Batf2 for infectious diseases and cancer. Oncotarget 37 26376615
2023 MANF ameliorates DSS-induced mouse colitis via restricting Ly6ChiCX3CR1int macrophage transformation and suppressing CHOP-BATF2 signaling pathway. Acta pharmacologica Sinica 31 36635421
2010 Serological survey of Toxoplasma gondii in schizophrenia patients referred to Psychiatric Hospital, Sari City, Iran. Tropical biomedicine 29 21399589
2023 CD36-BATF2\MYB Axis Predicts Anti-PD-1 Immunotherapy Response in Gastric Cancer. International journal of biological sciences 28 37781029
2021 BATF2 prevents glioblastoma multiforme progression by inhibiting recruitment of myeloid-derived suppressor cells. Oncogene 28 33452462
2018 Batf2 differentially regulates tissue immunopathology in Type 1 and Type 2 diseases. Mucosal immunology 26 30542107
2017 Inhibition of Bevacizumab-induced Epithelial-Mesenchymal Transition by BATF2 Overexpression Involves the Suppression of Wnt/β-Catenin Signaling in Glioblastoma Cells. Anticancer research 25 28739720
2007 Biochemistry of pyrethroid resistance in German cockroach (Dictyoptera, Blatellidae) from hospitals of Sari, Iran. Iranian biomedical journal 21 18392087
2020 miRNA-765 mediates multidrug resistance via targeting BATF2 in gastric cancer cells. FEBS open bio 20 32166887
2019 BATF2 prevents T-cell-mediated intestinal inflammation through regulation of the IL-23/IL-17 pathway. International immunology 20 30753547
2016 SARI, a novel target gene of glucocorticoid receptor, plays an important role in dexamethasone-mediated killing of B lymphoma cells. Cancer letters 18 26808579
2019 BATF2 reverses multidrug resistance of human gastric cancer cells by suppressing Wnt/β-catenin signaling. In vitro cellular & developmental biology. Animal 17 31140101
2018 Decrease in invasion of HTR-8/SVneo trophoblastic cells by interferon gamma involves cross-communication of STAT1 and BATF2 that regulates the expression of JUN. Cell adhesion & migration 16 29394132
2023 Establishing severe acute respiratory infection (SARI) surveillance in a sentinel hospital, Ireland, 2021 to 2022. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 15 37289427
2022 Bone marrow mesenchymal stem cells-derived exosomes suppress miRNA-5189-3p to increase fibroblast-like synoviocyte apoptosis via the BATF2/JAK2/STAT3 signaling pathway. Bioengineered 15 35246006
2022 m6A modification-mediated BATF2 suppresses metastasis and angiogenesis of tongue squamous cell carcinoma through inhibiting VEGFA. Cell cycle (Georgetown, Tex.) 15 35949109
2011 Transcription suppression of SARI (suppressor of AP-1, regulated by IFN) by BCR-ABL in human leukemia cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 15 21892628
2011 Age-specific seroprevalence of hepatitis A in Sari, northern Islamic Republic of Iran. Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit 15 22256409
2023 BATF2 promotes HSC myeloid differentiation by amplifying IFN response mediators during chronic infection. iScience 14 36824275
2019 BATF2 inhibits chemotherapy resistance by suppressing AP-1 in vincristine-resistant gastric cancer cells. Cancer chemotherapy and pharmacology 14 31549215
2024 BATF2 inhibits the stem cell-like properties and chemoresistance of gastric cancer cells through PTEN/AKT/β-catenin pathway. Theranostics 13 39629124
2021 Circ_0005927 Inhibits the Progression of Colorectal Cancer by Regulating miR-942-5p/BATF2 Axis. Cancer management and research 13 33732022
2015 The tumor-suppressive role of BATF2 in esophageal squamous cell carcinoma. Oncology reports 13 26135942
2024 ABBV-744 alleviates LPS-induced neuroinflammation via regulation of BATF2-IRF4-STAT1/3/5 axis. Acta pharmacologica Sinica 12 38862817
2023 BATF2 enhances proinflammatory cytokine responses in macrophages and improves early host defense against pulmonary Klebsiella pneumoniae infection. American journal of physiology. Lung cellular and molecular physiology 11 37724373
2023 BATF2 inhibits PD-L1 expression and regulates CD8+ T-cell infiltration in non-small cell lung cancer. The Journal of biological chemistry 11 37777155
2014 Report on patients with non transfusion-dependent β-thalassemia major being treated with hydroxyurea attending the Thalassemia Research Center, Sari, Mazandaran Province, Islamic Republic of Iran in 2013. Hemoglobin 11 24471558
2009 Seroprevalence of hepatitis C infection and associated risk factors among addicted prisoners in Sari-Iran. Pakistan journal of biological sciences : PJBS 11 19947179
2023 Nuclear export of BATF2 enhances colorectal cancer proliferation through binding to CRM1. Clinical and translational medicine 10 37151195
2021 BATF2 balances the T cell-mediated immune response of CADM with an anti-MDA5 autoantibody. Biochemical and biophysical research communications 10 33740622
2012 Species identification of birds nasal trichobilharzia in sari, north of iran. Iranian journal of parasitology 10 23323095
2024 Exosomal miR-361-3p promotes the viability of breast cancer cells by targeting ETV7 and BATF2 to upregulate the PAI-1/ERK pathway. Journal of translational medicine 9 38282047
2021 SARI inhibits growth and reduces survival of oral squamous cell carcinomas (OSCC) by inducing endoplasmic reticulum stress. Life sciences 9 34774620
2023 The role of BATF2 deficiency in immune microenvironment rearrangement in cervical cancer - New biomarker benefiting from combination of radiotherapy and immunotherapy. International immunopharmacology 8 37995570
2019 SARI suppresses colitis-associated cancer development by maintaining MCP-1-mediated tumour-associated macrophage recruitment. Journal of cellular and molecular medicine 8 31578820
2016 Occurrence of aflatoxin M₁ in commercial pasteurized milk samples in Sari, Mazandaran province, Iran. Mycotoxin research 8 26923243
2016 H1299R in coagulation Factor V and Glu429Ala in MTHFR genes in recurrent pregnancy loss in Sari, Mazandaran. International journal of reproductive biomedicine 8 27326418
2024 High prevalence of HPV-56 and HPV-39 in Sari, Iran: an analysis of genotype distribution. Virology journal 7 39304906
2023 Loss of the Immunomodulatory Transcription Factor BATF2 in Humans Is Associated with a Neurological Phenotype. Cells 6 36672163
2017 Iron Profile and Inflammatory Status of Overweight and Obese Women in Sari, North of Iran. International journal of hematology-oncology and stem cell research 6 28875005
2015 Inhibition of janus kinase 2 by compound AG490 suppresses the proliferation of MDA-MB-231 cells via up-regulating SARI (suppressor of AP-1, regulated by IFN). Iranian journal of basic medical sciences 6 26221484
2014 Cryptosporidium infection in patients with gastroenteritis in sari, iran. Iranian journal of parasitology 6 25848389
2010 Assessment of coagulation state and its related factors in thalassemia intermedia patients referred to thalassemia research center at Booali Sina Hospital Sari/IR Iran in 2007. Pakistan journal of biological sciences : PJBS 6 20973399
2025 BATF2 is a regulator of interferon-γ signaling in astrocytes during neuroinflammation. Cell reports 5 40057949
2021 Promotion Effect of EGCG on the Raised Expression of IL-23 through the Signaling of STAT3-BATF2-c-JUN/ATF2. Journal of agricultural and food chemistry 5 34227806
2016 Discovery of a Regulatory Motif for Human Satellite DNA Transcription in Response to BATF2 Overexpression. Anticancer research 5 26977016
2011 [Expression and significance of SARI and CCN1 in human colorectal carcinomas]. Zhonghua yi xue za zhi 5 22321784
2024 Epidemic profile of common respiratory viruses in association SARS CoV-2 among SARI and ARI-two year study. Molecular biology reports 4 38252354
2022 Blood RNA Sequencing Indicates Upregulated BATF2 and LY6E and Downregulated ISG15 and MT2A Expression in Children with Autism Spectrum Disorder. International journal of molecular sciences 4 36077244
2019 First Report of Biochemical Mechanisms of Insecticide Resistance in the Field Population of Culex pipiens (Diptera: Culicidae) from Sari, Mazandaran, North of Iran. Journal of arthropod-borne diseases 4 32368555
2015 Expression and mechanism of action of the SARI tumor suppressor in prostate cancer. International journal of clinical and experimental pathology 4 26339361
2025 Targeting BATF2-RGS2 axis reduces T-cell exhaustion and restores anti-tumor immunity. Molecular cancer 3 40442751
2024 Genomic characterization of Influenza A (H1N1)pdm09 and SARS-CoV-2 from Influenza Like Illness (ILI) and Severe Acute Respiratory Illness (SARI) cases reported between July-December, 2022. Scientific reports 3 38724525
2024 BATF2/SINHCAF regulates the quantity and function of macrophages infected with Mycobacterium Tuberculosis via regulation of TTC23 through Wnt/β-catenin pathway. International journal of biological macromolecules 3 39672395
2022 Seroepidemiology of HBV, HCV, HIV, HTLV, and CMV in Pregnant Women Referring to Sari Birth Cohort. Advanced biomedical research 3 36660762
2021 Frequency of blaIMP and blaSPM Metallo-β-Lactamase Genes among Carbapenem-Resistant Pseudomonas aeruginosa Clinical Isolates in Sari, North of Iran. Recent advances in anti-infective drug discovery 3 34961433
2018 Study on the Quality of Life Among the Cancer Patients at the Sari Comprehensive Cancer Center in 2017. Materia socio-medica 3 30061803
2014 Prevalence and genotypes of hepatitis B virus infection in patients underwent coronary angiography and coronary artery bypass grafting in mazandaran heart center, sari, iran. Medical archives (Sarajevo, Bosnia and Herzegovina) 3 25568563
2025 The BATF2-ATF3 axis exacerbates intervertebral disc degeneration via inducing mitochondrial dysfunction. International immunopharmacology 2 40267724
2023 Clinical Profile, Intensive Care Needs and Predictors of Outcome Among Children Admitted with Non-COVID Severe Acute Respiratory Illness (SARI) During the Pandemic. Indian journal of pediatrics 2 37870740
2016 Effects and mechanisms of action of SARI on androgen-independent prostate cancer (DU145) cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2 27739031
2025 Role of the basic leucine zipper transcription factor BATF2 in modulating immune responses and inflammation in health and disease. Journal of leukocyte biology 1 39504573
2025 BATF2 is a glutamine-responsive tumour suppressor required for type-I interferon-dependent anti-tumour immunity. Nature communications 1 41457098
2024 BATF2 is a regulator of interferon-γ signaling in astrocytes during neuroinflammation. bioRxiv : the preprint server for biology 1 39071355
2018 Endogenous SARI exerts oncogenic functions in human K562 leukemia cells by targeting the PI3K/Akt/mTOR and NF-κB signaling pathways. International journal of clinical and experimental pathology 1 31938099
2015 [The expression and clinical significance of BATF2 in oral tongue squamous cell carcinoma]. Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology 1 25779069
2011 Evaluation of serum C-reactive protein level and its related factors in hemodialysis patients in Sari, Iran. Pakistan journal of biological sciences : PJBS 1 22097096
2026 BATF2 reverses multidrug resistance of gastric cancer cells and centrosome clustering by suppressing ATM phosphorylation. Neoplasma 0 42059142
2026 Shenfu decoction attenuates radiation-induced heart disease by modulating the P53-MDM2 complex and the STAT1-BATF2 axis. Phytomedicine : international journal of phytotherapy and phytopharmacology 0 42139975
2026 Genomic and Molecular Characterisation of Respiratory Syncytial Virus in the National SARI Surveillance System Across Three Consecutive Seasons in North Macedonia (2022-2025). Acta medica academica 0 42169608
2025 BATF2-mediated control of astrocyte proliferation. The Journal of biological chemistry 0 40945729
2023 Effectiveness of vero cell inactivated vaccine against severe acute respiratory infections (SARI) in Sibu, Malaysia: A retrospective test-negative design. Human vaccines & immunotherapeutics 0 36705277
2023 Immune response evaluation after Sputnik V vaccination in Sari healthcare population. The journal of medical investigation : JMI 0 37940513
2019 [Effect of SARI Overexpression on Apoptosis of CBFL Cells and Its Mechanism]. Zhongguo shi yan xue ye xue za zhi 0 31418351
2015 [Biological Effects of the SARI Over-expression on K562 Cell Line]. Zhongguo shi yan xue ye xue za zhi 0 26117008
2011 [Influence of BCR-ABL inhibitor STI571 on SARI expression in K562 cells]. Zhongguo shi yan xue ye xue za zhi 0 21867603

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