Affinage

ATP5F1A

ATP synthase F(1) complex subunit alpha, mitochondrial · UniProt P25705

Round 2 corrected
Length
553 aa
Mass
59.8 kDa
Annotated
2026-04-28
91 papers in source corpus 12 papers cited in narrative 12 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ATP5F1A encodes the α-subunit of the mitochondrial F1-Fo ATP synthase (complex V), forming the α3β3 catalytic hexamer whose rotation-driven conformational changes couple the proton-motive force to ATP synthesis (PMID:8065448). Beyond oxidative phosphorylation, ATP5F1A resides on the endothelial cell surface where it serves as a functional receptor for angiostatin, mediating its antiproliferative, antiangiogenic activity (PMID:10077593). Complex V stability and mitophagy are regulated through post-translational modifications of ATP5F1A: TNK2/ACK1-mediated phosphorylation at Tyr243/Tyr246 stabilizes the complex and blocks the inhibitor ATP5IF1 (PMID:35895804), SIRT3-mediated deacetylation at Lys498 promotes PRKN-dependent mitophagy (PMID:41655128), and WWP2-mediated ubiquitination targets ATP5F1A for proteasomal degradation (PMID:37557013). De novo heterozygous missense variants in ATP5F1A cause complex V deficiency through dominant-negative disruption of oxidative phosphorylation, leading to neonatal-onset developmental and neurological disease (PMID:34483339, PMID:41053757).

Mechanistic history

Synthesis pass · year-by-year structured walk · 9 steps
  1. 1994 High

    Determination of how the α-subunit participates in catalysis: the 2.8 Å crystal structure of bovine F1-ATPase revealed that the α3β3 hexamer adopts asymmetric conformations around the central γ-shaft, establishing the rotary catalytic mechanism for ATP synthesis and defining the structural role of the α-subunit.

    Evidence X-ray crystallography of bovine mitochondrial F1-ATPase at 2.8 Å resolution

    PMID:8065448

    Open questions at the time
    • Post-translational regulation of the α-subunit was not addressed
    • No information on potential non-mitochondrial localization or function
  2. 1999 High

    Discovery that ATP5F1A has an extramitochondrial role: identification of the α-subunit on the endothelial cell surface as the functional receptor for angiostatin established a moonlighting function independent of mitochondrial ATP synthesis.

    Evidence Ligand blot, mass spectrometry, flow cytometry, and antibody-blockade experiments in human endothelial cells

    PMID:10077593

    Open questions at the time
    • Mechanism of ATP5F1A trafficking to the plasma membrane remains undefined
    • Whether cell-surface ATP synthase is catalytically active was not resolved
  3. 2021 Medium

    First genetic link of ATP5F1A to human disease: a recurrent de novo p.Arg207His variant was shown to cause neonatal complex V deficiency by disrupting the α–β subunit interface, demonstrating that single missense changes can dominantly impair oxidative phosphorylation.

    Evidence Exome sequencing, biochemical assays in patient-derived fibroblasts, and structural modelling

    PMID:34483339

    Open questions at the time
    • Only one recurrent variant characterized; spectrum of pathogenic variants unknown
    • No rescue or complementation experiment performed
  4. 2022 High

    Identification of a kinase-mediated regulatory switch on ATP5F1A: TNK2/ACK1 phosphorylates Tyr243/Tyr246, stabilizing complex V and preventing ATP5IF1 binding, thereby linking tyrosine kinase signaling to mitochondrial energy output and mitophagy control in cancer.

    Evidence In vitro kinase assay, site-directed mutagenesis, Co-IP, transgenic mouse model, and xenograft experiments in prostate cancer

    PMID:35895804

    Open questions at the time
    • Structural basis for how phosphorylation blocks ATP5IF1 binding not determined
    • Relevance of this phosphorylation outside prostate cancer cells not tested
  5. 2023 Medium

    Ubiquitin-dependent turnover of ATP5F1A was established: WWP2 ubiquitinates ATP5F1A for proteasomal degradation, connecting complex V abundance to an endothelial protective pathway in hypertension.

    Evidence Ubiquitination assay, proteasome inhibition, endothelial-specific WWP2 knockout mice, and in vivo hypertension model

    PMID:37557013

    Open questions at the time
    • Specific ubiquitination sites on ATP5F1A not mapped
    • Whether WWP2-mediated regulation occurs in non-endothelial cell types is unknown
  6. 2024 Medium

    A chimeric lncRNA (SFT2D2-TBX19) was shown to scaffold the TNK2-ATP5F1A interaction, mapping the functional domain on ATP5F1A and demonstrating that RNA-protein complexes modulate ATP synthase phosphorylation and α–β subunit stability.

    Evidence RNA-protein interaction assays, Co-IP of ATP5F1A–ATP5F1B, phosphorylation assays, and domain mapping in prostate cancer cells

    PMID:39540264

    Open questions at the time
    • Physiological relevance of SFT2D2-TBX19 outside prostate cancer is unclear
    • No structural data on the RNA–ATP5F1A interface
  7. 2024 Medium

    Cardiomyocyte-specific overexpression of ATP5F1A reversed cardiac remodeling in heart failure models, establishing ATP5F1A levels as limiting for cardiac bioenergetics and function.

    Evidence AAV9-mediated cardiomyocyte-specific overexpression in TAC and DCM mouse models, echocardiography, histology

    PMID:38910562

    Open questions at the time
    • Mechanism linking ATP5F1A restoration to reduced fibrosis not delineated
    • Long-term effects and safety not evaluated
  8. 2025 Medium

    Expanded genetic evidence confirmed dominant-negative pathogenicity: six additional de novo ATP5F1A missense variants caused complex V deficiency with uncoupled oxidative phosphorylation, and zebrafish knockdown linked ATP5F1A loss to motor neuron axon defects and impaired autophagy.

    Evidence C. elegans dominant-negative assay, quantitative proteomics, patient fibroblast bioenergetics (preprint); zebrafish morpholino knockdown with mRNA rescue, autophagy marker analysis

    PMID:40672495 PMID:41053757

    Open questions at the time
    • Preprint data (PMID:40672495) not yet peer-reviewed
    • Autophagy impairment mechanism downstream of ATP5F1A loss not fully characterized
    • Genotype–phenotype correlation across all known variants not systematically established
  9. 2026 Medium

    A deacetylation-dependent mitophagy switch was identified: SIRT3 deacetylates ATP5F1A at Lys498 to enable PRKN-dependent mitophagy, linking acetylation status of ATP5F1A to ferroptosis resistance and microvascular integrity in acute lung injury.

    Evidence Site-specific acetylation analysis, SIRT3 knockout and activation, siRNA knockdown, mitophagy and ferroptosis assays, in vivo acute lung injury mouse model

    PMID:41655128

    Open questions at the time
    • How K498 deacetylation mechanistically activates PRKN recruitment is not defined
    • Not yet replicated independently

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include how ATP5F1A traffics to the plasma membrane, the structural basis for how individual post-translational modifications (phosphorylation, acetylation, ubiquitination) cooperate to regulate complex V assembly and turnover, and comprehensive genotype–phenotype maps for disease-causing variants.
  • No structural data showing how Tyr243/246 phosphorylation or K498 acetylation alter complex V conformation
  • Mechanism of ATP5F1A targeting to the cell surface is unknown
  • Crosstalk among phosphorylation, acetylation, and ubiquitination on ATP5F1A is unexplored

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 3 GO:0140657 ATP-dependent activity 3
Localization
GO:0005739 mitochondrion 7 GO:0005886 plasma membrane 1
Pathway
R-HSA-1430728 Metabolism 4 R-HSA-1643685 Disease 3 R-HSA-9612973 Autophagy 3 R-HSA-382551 Transport of small molecules 2 R-HSA-392499 Metabolism of proteins 2
Partners
ATP5F1BATP5IF1PRKNSIRT3TNK2WWP2
Complex memberships
F1-ATPase α3β3γ subcomplexF1-Fo ATP synthase (complex V)

Evidence

Reading pass · 12 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1994 Crystal structure of bovine mitochondrial F1-ATPase at 2.8 Å resolution revealed that the three catalytic β-subunits differ in conformation and bound nucleotide, and that the α-subunit (ATP5F1A ortholog) participates in an α3β3 subassembly whose rotation relative to the γ-subunit drives the catalytic cycle, supporting a rotary mechanism for ATP synthesis. X-ray crystallography at 2.8 Å resolution Nature High 8065448
1999 The α-subunit of ATP synthase (ATP5F1A) is present on the surface of human umbilical vein endothelial cells, where it binds angiostatin (a proteolytic fragment of plasminogen) in a concentration-dependent, saturable, plasminogen-independent manner; antibody blockade of the α-subunit inhibited angiostatin's antiproliferative effect on endothelial cells by up to 90%, establishing cell-surface ATP5F1A as a functional mediator of angiostatin's antiangiogenic activity. Ligand blot of plasma membrane fractions, amino-terminal sequencing, peptide mass fingerprinting, binding assays with recombinant α-subunit, flow cytometry, immunofluorescence, anti-α-subunit antibody functional blockade Proceedings of the National Academy of Sciences of the United States of America High 10077593
2021 A recurrent de novo heterozygous missense substitution c.620G>A [p.(Arg207His)] in ATP5F1A causes neonatal-onset complex V deficiency; patient-derived fibroblasts showed multiple deficits in complex V function and expression in vitro, and structural modelling predicts the substitution creates an abnormal negative-charge region on ATP5F1A's β-subunit-interacting surface adjacent to the active site, disrupting normal α–β subunit interaction. Exome sequencing, functional assays in patient-derived fibroblasts (complex V activity and expression), structural modelling European journal of human genetics : EJHG Medium 34483339
2022 The non-receptor tyrosine kinase TNK2/ACK1 directly phosphorylates ATP5F1A at Tyr243 and Tyr246 (Tyr200 and Tyr203 in the mature protein); this phosphorylation increases complex V stability and mitochondrial energy output in prostate cancer cells, and prevents ATP5F1A from binding its physiological inhibitor ATP5IF1, thereby sustaining mitochondrial activity to promote cancer cell growth. TNK2 inhibitor (R)-9b reversed this phosphorylation, induced mitophagy, and suppressed prostate tumor growth. Transgenic Tnk2 mice displayed increased p-Y-ATP5F1A and loss of mitophagy. Kinase assay, site-directed mutagenesis (Y243/246A mutant), Co-IP, mitochondrial function assays, Tnk2 transgenic mouse model, tumor xenograft experiments Autophagy High 35895804
2022 Fucoidan from Fucus vesiculosus (FvF) exerts neuroprotective effects in an MPTP-induced Parkinson's disease mouse model by targeting ATP5F1a as a key protein responsible for alleviating mitochondrial dysfunction, preventing neuronal apoptosis and dopaminergic neuron loss. MPTP mouse model, mechanistic investigation identifying ATP5F1a as FvF target (binding/functional assays), mitochondrial function assessment Carbohydrate polymers Low 36657849
2023 The HECT-type E3 ubiquitin ligase WWP2 ubiquitinates ATP5F1A (ATP synthase mitochondrial F1 complex subunit alpha), targeting it for proteasomal degradation; atorvastatin upregulates WWP2, leading to ATP5F1A degradation that stabilizes the Bcl-2/Bax ratio in the mitochondrial apoptosis pathway, thereby protecting vascular endothelial cells from angiotensin II-induced injury in hypertension. Ubiquitination assay, proteasome pathway inhibition, WWP2 overexpression/knockout (including endothelial cell-specific KO mice), Western blot, in vivo hypertension model Biomedicine & pharmacotherapy Medium 37557013
2024 The chimeric RNA SFT2D2-TBX19 functions as a lncRNA that interacts with ATP5F1A and increases TNK2/ACK1-mediated phosphorylation of ATP5F1A, which stabilizes the interaction between ATP5F1A and ATP5F1B (β-subunit), thereby enhancing mitochondrial ATP synthase activity and ATP production to support prostate cancer cell proliferation. The region spanning 1801–2400 bp of SFT2D2-TBX19 and the intermediate structural domain of ATP5F1A are the key functional areas. RNA-protein interaction assays, Co-IP of ATP5F1A–ATP5F1B, phosphorylation assays, ATP synthase activity assay, domain mapping Advanced science Medium 39540264
2024 Overexpression of ATP5F1A specifically in cardiomyocytes (via adeno-associated virus 9) improved heart function and morphology, and reduced fibrosis and cardiomyocyte size in transverse aortic constriction and dilated cardiomyopathy heart failure mouse models, establishing ATP5F1A as a mediator of cardiac reverse remodeling. Single-nucleus RNA sequencing of human cardiac tissue, cardiomyocyte-specific AAV9 overexpression in mouse heart failure models, echocardiography, pathological staining Circulation. Heart failure Medium 38910562
2025 A de novo missense variant (c.1252G>A, p.Gly418Arg) in ATP5F1A reduces protein stability and expression without affecting mitochondrial localization. In zebrafish, atp5fa1 knockdown caused growth retardation, motor dysfunction, and impaired motor neuron axon development; rescue with human wild-type ATP5F1A mRNA partially restored motor neuron morphology. Knockdown increased P62 and decreased Lc3b-II expression, suggesting inhibition of autophagy as a pathomechanism. Whole-exome sequencing, HEK293T transfection (Western blot, immunofluorescence), morpholino knockdown in zebrafish, behavioral assays, RNA sequencing, qPCR, Western blot Journal of translational medicine Medium 41053757
2025 Six heterozygous de novo missense variants in ATP5F1A cause a dominant negative disruption of complex V: functional evaluation in C. elegans confirmed dominant negative mechanism; biochemical/proteomics studies in proband-derived blood cells and fibroblasts showed marked reduction in complex V abundance and activity; mitochondrial physiology studies revealed increased oxygen consumption but decreased mitochondrial membrane potential and ATP levels, indicating uncoupled oxidative phosphorylation as the pathophysiologic mechanism. This differs from the previously reported p.Arg207His variant mechanism. C. elegans dominant negative functional assay, quantitative proteomics, complex V activity assay, mitochondrial membrane potential and ATP measurement, oxygen consumption rate in fibroblasts medRxivpreprint Medium 40672495
2026 SIRT3 (sirtuin 3) deacetylates ATP5F1A at lysine 498; LPS-induced acetylation of K498 on ATP5F1A impairs PRKN/parkin-dependent mitophagy. SIGMAR1 activation promotes SIRT3-mediated deacetylation of ATP5F1A at K498, which is required for SIGMAR1-mediated mitophagy and protection against endothelial ferroptosis and microvascular hyperpermeability in acute lung injury. Site-specific acetylation analysis (K498), SIRT3 KO and activation, siRNA knockdown of ATP5F1A, mitophagy assays (GFP-LC3, Western blot for P62/LC3), cell viability/ferroptosis assays, in vivo ALI mouse model Autophagy Medium 41655128
2025 DDIT4L (DNA damage-inducible transcript 4-like) is transported into mitochondria via TOM40 and directly interacts with the α-subunit of ATP synthase (ATP5F1A/ATP5A), inhibiting mitochondrial function and inducing tumor cell apoptosis in glioblastoma; a synthetic peptide DDIT4L V125–P132 recapitulated this tumor-suppressive effect. Lentiviral overexpression, PDX mouse model, co-immunoprecipitation of DDIT4L with ATP synthase α-subunit, mitochondrial function assays, apoptosis assays, synthetic peptide functional validation bioRxivpreprint Low bio_10.1101_2025.07.27.666981

Source papers

Stage 0 corpus · 91 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1994 Structure at 2.8 A resolution of F1-ATPase from bovine heart mitochondria. Nature 2506 8065448
2012 Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 1718 22658674
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2011 Systematic and quantitative assessment of the ubiquitin-modified proteome. Molecular cell 1334 21906983
2016 ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure. Cell 1233 26777405
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
2014 A proteome-scale map of the human interactome network. Cell 977 25416956
2018 VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell discovery 829 29507755
2003 Complete sequencing and characterization of 21,243 full-length human cDNAs. Nature genetics 754 14702039
2011 A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Molecular & cellular proteomics : MCP 749 21890473
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2012 A census of human soluble protein complexes. Cell 689 22939629
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2008 Large-scale proteomics and phosphoproteomics of urinary exosomes. Journal of the American Society of Nephrology : JASN 607 19056867
2017 Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15. Science (New York, N.Y.) 533 28302793
2011 Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Cell 507 21565611
2010 Orm family proteins mediate sphingolipid homeostasis. Nature 488 20182505
1999 Angiostatin binds ATP synthase on the surface of human endothelial cells. Proceedings of the National Academy of Sciences of the United States of America 439 10077593
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2022 OpenCell: Endogenous tagging for the cartography of human cellular organization. Science (New York, N.Y.) 432 35271311
2010 Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery. Journal of proteome research 422 20020773
2013 The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. The Journal of biological chemistry 413 23463506
2005 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Genome research 409 16344560
2015 Panorama of ancient metazoan macromolecular complexes. Nature 407 26344197
2004 Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. Current biology : CB 386 15324660
2005 Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways. Proceedings of the National Academy of Sciences of the United States of America 383 16009940
2004 14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking. The Biochemical journal 372 14744259
2007 Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Proceedings of the National Academy of Sciences of the United States of America 360 17620599
2011 Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer. Cancer cell 356 21575865
2012 Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways. Molecular biology of the cell 118 22535525
2015 Aberrant ORM (yeast)-like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice. The Journal of allergy and clinical immunology 107 25842287
2019 The ORMDL/Orm-serine palmitoyltransferase (SPT) complex is directly regulated by ceramide: Reconstitution of SPT regulation in isolated membranes. The Journal of biological chemistry 91 30700557
2013 TORC1-regulated protein kinase Npr1 phosphorylates Orm to stimulate complex sphingolipid synthesis. Molecular biology of the cell 86 23363605
2018 Orm/ORMDL proteins: Gate guardians and master regulators. Advances in biological regulation 69 30193828
2013 Orm proteins integrate multiple signals to maintain sphingolipid homeostasis. The Journal of biological chemistry 62 23737533
1987 Orosomucoid (ORM) typing by isoelectric focusing: evidence for gene duplication of ORM1 and genetic polymorphism of ORM2. Human genetics 50 3679210
1983 delta-Aminolevulinatedehydrase: synteny with ABO-AK1-ORM (and assignment to chromosome 9). Clinical genetics 45 6839527
2022 TNK2/ACK1-mediated phosphorylation of ATP5F1A (ATP synthase F1 subunit alpha) selectively augments survival of prostate cancer while engendering mitochondrial vulnerability. Autophagy 35 35895804
2019 Role of acute-phase protein ORM in a mice model of ischemic stroke. Journal of cellular physiology 35 31026065
1987 Three new orosomucoid (ORM) variants revealed by isoelectric focusing and print immunofixation. Human genetics 35 3679213
2016 ORM Expression Alters Sphingolipid Homeostasis and Differentially Affects Ceramide Synthase Activity. Plant physiology 33 27506241
2013 Pharmacological characterisation of a structurally novel α2C-adrenoceptor antagonist ORM-10921 and its effects in neuropsychiatric models. Basic & clinical pharmacology & toxicology 32 23718812
2022 Fucoidan from Fucus vesiculosus prevents the loss of dopaminergic neurons by alleviating mitochondrial dysfunction through targeting ATP5F1a. Carbohydrate polymers 30 36657849
2020 Unregulated Sphingolipid Biosynthesis in Gene-Edited Arabidopsis ORM Mutants Results in Nonviable Seeds with Strongly Reduced Oil Content. The Plant cell 27 32527862
2016 ORM Promotes Skeletal Muscle Glycogen Accumulation via CCR5-Activated AMPK Pathway in Mice. Frontiers in pharmacology 26 27679573
1988 Orosomucoid (ORM) typing by isoelectric focusing: evidence for an additional duplicated ORM1 locus haplotype and close linkage of two ORM loci. American journal of human genetics 24 3400642
2018 Estrogen weakens muscle endurance via estrogen receptor-p38 MAPK-mediated orosomucoid (ORM) suppression. Experimental & molecular medicine 23 29869624
2009 Pro-angiogenic properties of orosomucoid (ORM). Experimental cell research 23 19651122
2014 A PET Tracer for Brain α2C Adrenoceptors, (11)C-ORM-13070: Radiosynthesis and Preclinical Evaluation in Rats and Knockout Mice. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 22 24799619
2018 Reduced Levels of ATP Synthase Subunit ATP5F1A Correlate with Earlier-Onset Prostate Cancer. Oxidative medicine and cellular longevity 20 30538797
2014 Test-retest reliability of (11)C-ORM-13070 in PET imaging of α2C-adrenoceptors in vivo in the human brain. European journal of nuclear medicine and molecular imaging 19 25201008
2014 ¹¹C-ORM-13070, a novel PET ligand for brain α₂C-adrenoceptors: radiometabolism, plasma pharmacokinetics, whole-body distribution and radiation dosimetry in healthy men. European journal of nuclear medicine and molecular imaging 17 24838249
2014 Efficacy of selective NCX inhibition by ORM-10103 during simulated ischemia/reperfusion. European journal of pharmacology 17 24975099
1990 Orosomucoid (ORM) typing by isoelectric focusing: evidence for several new variants including ORM1 and ORM2 silent alleles. Vox sanguinis 16 2339522
2014 Amphetamine decreases α2C-adrenoceptor binding of [11C]ORM-13070: a PET study in the primate brain. The international journal of neuropsychopharmacology 15 25522417
2022 ORM 1 as a biomarker of increased vascular invasion and decreased sorafenib sensitivity in hepatocellular carcinoma. Bosnian journal of basic medical sciences 14 35765957
2020 Blockade of sodium‑calcium exchanger via ORM-10962 attenuates cardiac alternans. Journal of molecular and cellular cardiology 14 33383036
2015 Validation of [(11) C]ORM-13070 as a PET tracer for alpha2c -adrenoceptors in the human brain. Synapse (New York, N.Y.) 14 25530024
1992 Comparative mapping of mouse chromosome 4 and human chromosome 9: Lv, Orm, and Hxb are closely linked on mouse chromosome 4. Mammalian genome : official journal of the International Mammalian Genome Society 12 1379092
1997 Comparative genomic hybridization analysis of Y79 and FISH mapping indicate the amplified human mitochondrial ATP synthase alpha-subunit gene (ATP5A) maps to chromosome 18q12-->q21. Cytogenetics and cell genetics 11 9284928
2021 A recurrent de novo ATP5F1A substitution associated with neonatal complex V deficiency. European journal of human genetics : EJHG 9 34483339
2018 Validation of an LC-MS/MS method for simultaneous quantitation of enzalutamide, N-desmethylenzalutamide, apalutamide, darolutamide and ORM-15341 in mice plasma and its application to a mice pharmacokinetic study. Journal of pharmaceutical and biomedical analysis 9 29709784
2015 Detecting a dexmedetomidine-evoked reduction of noradrenaline release in the human brain with the alpha2C-adrenoceptor PET ligand [11C]ORM-13070. Synapse (New York, N.Y.) 9 26562363
1988 AIDS: no association with the genetic systems GC (D-binding protein), ORM (orosomucoid = alpha-1-acid glycoprotein), and A2HS (alpha-2-HS-glycoprotein). Infection 9 3162895
2023 Atorvastatin rescues vascular endothelial injury in hypertension by WWP2-mediated ubiquitination and degradation of ATP5A. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 8 37557013
2021 Dissecting the regulatory roles of ORM proteins in the sphingolipid pathway of plants. PLoS computational biology 8 33507896
2017 A sandwich ELISA for porcine alpha-1 acid glycoprotein (pAGP, ORM-1) and further demonstration of its use to evaluate growth potential in newborn pigs. Domestic animal endocrinology 8 28551395
2013 Real-time monitoring of cell viability and cell density on the basis of a three dimensional optical reflectance method (3D-ORM): investigation of the effect of sub-lethal and lethal injuries. Journal of industrial microbiology & biotechnology 7 23604555
2024 Chimeric SFT2D2-TBX19 Promotes Prostate Cancer Progression by Encoding TBX19-202 Protein and Stabilizing Mitochondrial ATP Synthase through ATP5F1A Phosphorylation. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 6 39540264
2016 ORM-3819 promotes cardiac contractility through Ca(2+) sensitization in combination with selective PDE III inhibition, a novel approach to inotropy. European journal of pharmacology 6 26872993
1994 Serum protein polymorphism in Chuetas (Majorcan Jews)--GC, A2HS, ORM, ITI and HP. Gene geography : a computerized bulletin on human gene frequencies 6 7547602
2024 The structure of the Orm2-containing serine palmitoyltransferase complex reveals distinct inhibitory potentials of yeast Orm proteins. Cell reports 5 39167489
2020 Application of the PET ligand [11C]ORM-13070 to examine receptor occupancy by the α2C-adrenoceptor antagonist ORM-12741: translational validation of target engagement in rat and human brain. EJNMMI research 5 33296042
2024 Overexpression of ATP5F1A in Cardiomyocytes Promotes Cardiac Reverse Remodeling. Circulation. Heart failure 4 38910562
2024 Integration of fungal transcriptomics and metabolomics provides insights into the early interaction between the ORM fungus Tulasnella sp. and the orchid Serapias vomeracea seeds. IMA fungus 4 39456087
2002 Identification and characterization of polymorphisms at the HAS alpha1-acid glycoprotein (ORM*) gene locus in Caucasians. Genetics and molecular research : GMR 4 14963818
1994 A linkage study of affective disorder with DNA markers for the ABO-AK1-ORM linkage group near the dopamine beta hydroxylase gene. Biological psychiatry 4 7811839
2024 Orm proteins control ceramide synthesis and endocytosis via LCB-mediated Ypk1 regulation. Journal of lipid research 3 39490931
2023 Proteomic analyses identify HK1 and ATP5A to be overexpressed in distant metastases of lung adenocarcinomas compared to matched primary tumors. Scientific reports 3 38016997
2025 ATP5F1A deficiency causes developmental delay and motor dysfunction in humans and zebrafish. Journal of translational medicine 2 41053757
2023 Synthesis and Antitumor Activity of Brominated-Ormeloxifene (Br-ORM) against Cervical Cancer. ACS omega 2 37901538
1991 Orosomucoid (ORM 1) subtyping and formal genetics. Human genetics 2 1879829
2024 Single-dose methamphetamine administration impairs ORM retrieval in mice via excessive DA-mediated inhibition of PrLGlu activity. Acta pharmacologica Sinica 1 38914676
2026 SIRT3-mediated mitophagy by deacetylating ATP5F1A involved in the protective effects of SIGMAR1/Sigma-1 receptor against ferroptosis and microvascular hyperpermeability in lipopolysaccharide-induced acute lung injury. Autophagy 0 41655128
2026 A New Case of a Neurodevelopmental Disorder and Myoclonic Dystonia Associated with the C.1404del Variant of the ATP5F1A Gene. International medical case reports journal 0 41743395
2026 Generative design and validation of therapeutic peptides for glioblastoma based on a potential target ATP5A. Briefings in bioinformatics 0 42033056
2025 Dominant negative ATP5F1A variants disrupt oxidative phosphorylation causing neurological disorders. medRxiv : the preprint server for health sciences 0 40672495
2024 Preclinical in vitro and in vivo evaluation of [11C]ORM-13070 as PET ligand for alpha-2C adrenergic receptor occupancy using PET imaging in non-human primates. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 0 39479946
1981 [Plasma protein spectrum of dog blood during treatment of hypoxia with a Sever-OMR membrane oxygenator]. Biulleten' eksperimental'noi biologii i meditsiny 0 7248496