Affinage

AP2A1

AP-2 complex subunit alpha-1 · UniProt O95782

Length
977 aa
Mass
107.5 kDa
Annotated
2026-06-09
34 papers in source corpus 20 papers cited in narrative 20 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

AP2A1 is the alpha-1 subunit of the AP-2 clathrin adaptor complex and serves as a core component of clathrin-mediated endocytosis (CME), recruited to endocytic sites concurrently with clathrin to drive cargo internalization (PMID:28484480, PMID:32027876). It mediates clathrin-dependent uptake of diverse transmembrane cargo: it routes the IGF-1 receptor to Rab11-positive slow-recycling endosomes in keratinocytes, controlling downstream AKT and MAPK signaling (PMID:32027876); it internalizes claudin-2 for lysosomal degradation during starvation-induced autophagy to tighten junctional permeability (PMID:34964704); and it cooperates with DNAJC5 to promote EGFR endocytosis and recycling (PMID:40374748). As an adaptor it also governs receptor trafficking in neurons, regulating μ-opioid receptor externalization in thalamic neurons (PMID:41326807) and acting downstream of FMRP-mediated translational repression, where loss of FMRP raises AP2A1 levels and enhances AP-2-dependent AMPA receptor endocytosis (PMID:40740492). Beyond classical CME, AP2A1 functions as a scaffold recruited by MYO1F together with ATAT1 to promote α-tubulin acetylation, controlling SYK/CARD9 trafficking in antifungal innate immune signaling (PMID:34301894); it physically interacts with and GTP-loads Rab7 to recruit DIC1 and RILP, enhancing retrograde axonal autophagosome transport and clearing Aβ in Alzheimer's disease models (PMID:40490761); it acts as a required mediator of Smad3 phosphorylation downstream of full-length IL-33 and within a circEIF3I–SMAD3–AP2A1 complex that delivers SMAD3 to TGFβRI on endosomes (PMID:32977155, PMID:37689715); and it accumulates along actin stress fibers in senescent fibroblasts, co-localizing with integrin β1 to reinforce cell anchorage (PMID:39848456). AP2A1 is required for hematopoietic stem/progenitor cell specification in vivo (PMID:27797851) and accumulates in the detergent-insoluble fraction of Alzheimer's disease brains, isoform-specifically labeling neurofibrillary tangles (PMID:34820873).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 2006 Medium

    Established an early physical partner for AP2A1, placing the adaptin in a defined protein-protein context in germ cells before its endocytic roles were dissected.

    Evidence Reciprocal co-immunoprecipitation and confocal co-localization with m-Numb in mouse testis germ cells

    PMID:17127749

    Open questions at the time
    • No functional consequence of the Numb interaction tested
    • Cargo or pathway specificity not defined
  2. 2010 Medium

    Demonstrated functional requirement for AP2A1 in CME by showing it is needed for clathrin-dependent viral entry, moving beyond association to loss-of-function dependence.

    Evidence siRNA knockdown, dominant-negative expression, and pharmacological inhibition of HEV71 entry in rhabdomyosarcoma cells

    PMID:20956521

    Open questions at the time
    • Direct cargo-AP2A1 contact not mapped
    • Whether AP2A1 acts in canonical AP-2 complex versus independently not resolved
  3. 2016 Medium

    Connected AP2A1 to a developmental program, establishing an organismal requirement distinct from cell-autonomous endocytosis assays.

    Evidence Genome-wide RNAi screen with zebrafish in vivo knockdown of Ap2a1 impairing HSPC development

    PMID:27797851

    Open questions at the time
    • Endocytic cargo driving the HSPC phenotype unidentified
    • Tissue-specific mechanism not dissected
  4. 2020 High

    Provided the most rigorous mechanistic anchor: AP2A1 sorts a specific receptor (IGF1R) into a defined recycling route and controls its downstream signaling output.

    Evidence shRNA knockdown, reciprocal Co-IP, multimodal imaging, phospho-pathway and Rab11 sorting assays in human keratinocytes

    PMID:32027876

    Open questions at the time
    • Direct sorting motif on IGF1R recognized by AP2A1 not mapped
    • Generalizability of Rab11 routing to other cargo unknown
  5. 2020 Medium

    Extended AP2A1 from a structural endocytic role into a signaling mediator, showing it is required for Smad3 phosphorylation downstream of full-length IL-33 via a TGFBR-dependent pathway.

    Evidence siRNA loss-of-function and overexpression gain-of-function with Smad3 phosphorylation readout in lung fibroblasts; parallel AP2A1 requirement for adenoviral entry

    PMID:32852546 PMID:32977155

    Open questions at the time
    • Direct AP2A1-TGFBR or AP2A1-Smad3 contact not established in this work
    • How an adaptor mediates Smad3 activation mechanistically unclear
  6. 2021 Medium

    Revealed a moonlighting scaffold function: AP2A1 is recruited by MYO1F to promote α-tubulin acetylation, linking it to cytoskeletal modification and innate immune signaling rather than membrane internalization.

    Evidence Co-IP in macrophages plus Myo1f-knockout mice and antifungal infection models

    PMID:34301894

    Open questions at the time
    • Whether AP2A1's adaptor surface or AP-2 complex is involved not resolved
    • Direct AP2A1-tubulin contact not mapped
  7. 2021 Medium

    Linked AP2A1 to autophagy-coupled cargo degradation and to disease pathology, showing it bridges claudin-2/clathrin/LC3 for lysosomal turnover and isoform-specifically marks neurofibrillary tangles.

    Evidence Co-IP, fractionation and inhibitor assays for CLDN2 in intestinal epithelium; validated immunohistochemistry/fractionation in Alzheimer's disease brains

    PMID:34820873 PMID:34964704

    Open questions at the time
    • Causal role of AP2A1 in tangle formation versus association unknown
    • Mechanism coupling CME to LC3/lysosomal route not detailed
  8. 2023 Medium

    Placed AP2A1 within a circRNA-scaffolded signaling complex, defining how it recruits SMAD3 to endosomal TGFβRI to drive oncogenic signaling.

    Evidence Co-IP, MS2-RNA affinity purification, RNA pulldown and IF establishing the circEIF3I-SMAD3-AP2A1 ternary complex in pancreatic cancer

    PMID:37689715

    Open questions at the time
    • Direct AP2A1-SMAD3 binding interface not mapped
    • Generality beyond pancreatic cancer untested
  9. 2025 High

    Defined a direct biochemical activity beyond adaptor function: AP2A1 binds and GTP-loads Rab7 to recruit retrograde transport machinery and restore autophagic flux.

    Evidence Co-IP, Rab7 GTPase activation assay, live imaging, and in vivo rescue in Alzheimer's disease mouse models

    PMID:40490761

    Open questions at the time
    • Mechanism by which AP2A1 catalyzes or promotes Rab7 GTP-loading unresolved
    • Relationship to its CME role in the same neurons unclear
  10. 2025 Medium

    Showed AP2A1 dosage is set by FMRP translational control and that it governs neuronal receptor endocytosis, connecting it to fragile X syndrome and synaptic cargo trafficking.

    Evidence FMRP RNA-binding, quantitative proteomics, endocytosis assays and shRNA rescue; plus Co-IP/chemogenetics for μ-opioid receptor trafficking in PVT neurons

    PMID:40740492 PMID:41326807

    Open questions at the time
    • Direct FMRP-AP2A1 mRNA binding site not mapped
    • Whether AP2A1 directly binds receptor sorting motifs in neurons untested
  11. 2025 Medium

    Implicated AP2A1 in cellular senescence through a cytoskeletal/adhesion role, showing bidirectional control of senescence phenotypes via integrin β1 translocation.

    Evidence shRNA knockdown, overexpression, co-localization and live-cell imaging along actin stress fibers in senescent fibroblasts

    PMID:39848456

    Open questions at the time
    • Molecular basis of AP2A1 movement along stress fibers unknown
    • Direct AP2A1-integrin β1 contact not established
  12. 2025 Medium

    Tied AP2A1 expression to oncogenic EGFR trafficking and EMT, positioning it downstream of growth-factor signaling pathways in cancer.

    Evidence DNAJC5-AP2A1 Co-IP and knockdown affecting EGFR endocytosis; MDK/PI3K-AKT regulation of AP2A1 in colorectal cancer with functional assays

    PMID:40374748 PMID:42073635

    Open questions at the time
    • Whether AP2A1 directly binds EGFR sorting signals not mapped
    • Causal contribution of AP2A1 to EMT versus correlation incompletely separated

Open questions

Synthesis pass · forward-looking unresolved questions
  • How AP2A1's canonical AP-2 adaptor function mechanistically relates to its non-endocytic activities (Rab7 GTP-loading, tubulin acetylation scaffolding, SMAD3 recruitment, integrin translocation) and which depend on the intact AP-2 complex remains unresolved.
  • No structural model distinguishing adaptor versus moonlighting surfaces
  • Direct cargo-recognition motifs not mapped for most substrates
  • Whether functions are AP-2-complex-dependent or AP2A1-autonomous untested

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 4 GO:0098772 molecular function regulator activity 2
Localization
GO:0005886 plasma membrane 3 GO:0031410 cytoplasmic vesicle 3 GO:0005768 endosome 2 GO:0005856 cytoskeleton 2
Pathway
R-HSA-5653656 Vesicle-mediated transport 4 R-HSA-162582 Signal Transduction 3 R-HSA-9612973 Autophagy 3 R-HSA-168256 Immune System 2
Partners
AP2B1CLDN2DNAJC5EGFRIGF1RMYO1FRAB7SMAD3
Complex memberships
AP-2 clathrin adaptor complexcircEIF3I-SMAD3-AP2A1 complex

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2006 AP2A1 (alpha-adaptin, component of clathrin-coated vesicles) physically associates with m-Numb in mouse testis germ cells, as demonstrated by co-immunoprecipitation, and the two proteins co-localize by confocal immunofluorescence microscopy of seminiferous tubules and isolated germ cells. Co-immunoprecipitation; confocal immunofluorescence microscopy Reproduction (Cambridge, England) Medium 17127749
2010 AP2A1 is required for clathrin-mediated endocytosis (CME)-dependent entry of human enterovirus 71 (HEV71) into rhabdomyosarcoma cells; siRNA knockdown of AP2A1 significantly inhibited HEV71 infection in a dose-dependent manner, placing AP2A1 in the CME pathway essential for viral entry. siRNA knockdown; immunofluorescence co-localization; dominant-negative mutant expression; drug inhibition assays The Journal of biological chemistry Medium 20956521
2016 AP2A1 (along with AP2A2 and AP2B1) shows increased protein levels associated with the EGFR interactome in erlotinib-resistant non-small cell lung cancer cells (HCC4006rERLO0.5) compared to parental cells, identified by affinity purification coupled with mass spectrometry. Affinity purification-mass spectrometry (AP-MS) European journal of pharmaceutical sciences Low 27112992
2017 AP2A1 (alpha subunit of AP-2) is recruited to clathrin-mediated endocytosis sites concurrently with clathrin in Arabidopsis plant cells, as shown by TIRF microscopy using a departure assay; this temporal recruitment pattern differs from AP2M (mu subunit), which is not recruited in concert with clathrin. Total internal reflection fluorescence (TIRF) microscopy; automated departure assay Frontiers in plant science Low 28484480
2016 Ap2a1 is required for hematopoietic stem/progenitor cell (HSPC) specification and development; knockdown of Ap2a1 in zebrafish impaired HSPC development in vivo, validating it as a gene essential for the endothelial-to-hematopoietic transition identified in a genome-wide RNAi screen. Genome-wide RNAi screen (in vitro ESC differentiation); zebrafish in vivo knockdown validation EMBO reports Medium 27797851
2020 AP2A1/2 complex mediates clathrin-dependent endocytosis of IGF-1 receptor (IGF1R) in human keratinocytes; concurrent shRNA knockdown of AP2A1/2 and FLOT1/2 reduced IGF1R association with clathrin, internalization, and downstream pathway activation (phospho-IGF1R, phospho-AKT, phospho-MAPK) by >50%. AP2A1/2-mediated endocytosis routes IGF1R to Rab11-positive slow recycling endosomes, distinguishing it from the Flot-1/Rab4 fast-recycling pathway. shRNA knockdown; confocal/TIRF/SIM microscopy; co-immunoprecipitation; Western blot (phosphorylation assays); Rab11 association assay The Journal of investigative dermatology High 32027876
2020 AP2A1 and AP2B1 subunits of AP-2 complex are upregulated by full-length IL-33 (FLIL33) overexpression in human lung fibroblasts, and siRNA-mediated knockdown of AP2A1/AP2B1 blocked FLIL33-induced Smad3 phosphorylation, while AP-2 subunit overexpression induced Smad3 phosphorylation independently of FLIL33, placing AP2A1 as a required mediator of TGFBR-dependent Smad3 activation downstream of FLIL33. siRNA knockdown; Western blotting; overexpression experiments Cellular immunology Medium 32977155
2020 AP2A1 siRNA knockdown and pharmacological inhibition of clathrin-mediated endocytosis blocked HAdV-D37 (human adenovirus type 37) early gene expression in human corneal epithelial cells, establishing AP2A1 as required for this noncanonical clathrin-mediated viral entry pathway. siRNA knockdown; quantitative PCR; Western blot; chemical inhibitor assays Investigative ophthalmology & visual science Medium 32852546
2021 AP2A1 (alpha-1 subunit of AP-2) associates with CLDN2 (claudin-2), clathrin, and LC3 upon starvation-induced autophagy in intestinal epithelial cells, as shown by co-immunoprecipitation; this interaction facilitates clathrin-mediated endocytosis of CLDN2 followed by lysosomal degradation, thereby reducing tight junction permeability. Co-immunoprecipitation; membrane fractionation; immunofluorescence; pharmacological inhibition Autophagy Medium 34964704
2021 AP2A1 is recruited by MYO1F as an adaptor to α-tubulin during Dectin-1-induced signaling in macrophages; MYO1F acts as a scaffold recruiting both AP2A1 and α-tubulin N-acetyltransferase 1 (ATAT1) to α-tubulin to promote its acetylation, which in turn controls membrane-to-cytoplasm trafficking of SYK and CARD9 required for antifungal innate immune signaling. Co-immunoprecipitation; knockdown (Myo1f-deficient mice); in vivo infection models; Western blot Proceedings of the National Academy of Sciences of the United States of America Medium 34301894
2021 AP2A1 colocalizes with tau pathology (neurofibrillary tangles) in Alzheimer's disease brains and is present in the detergent-insoluble fraction of cognitively impaired but not control brains, in an isoform-specific manner (AP2A1 but not AP2A2 labels neurofibrillary tangles), as determined by immunohistochemistry and immunofluorescence with antibody specificity validated by immunoblot after plasmid transfection. Immunoblot (after plasmid transfection for antibody validation); immunohistochemistry; immunofluorescence; fractionation Neuropathology and applied neurobiology Medium 34820873
2023 AP2A1 binds directly to the circRNA circEIF3I and interacts with SMAD3, forming a ternary complex (circEIF3I–SMAD3–AP2A1) that facilitates recruitment of SMAD3 to TGFβRI on early endosomes, thereby promoting SMAD3 phosphorylation and activation of MMPs in pancreatic cancer cells. Co-immunoprecipitation; MS2-RNA affinity purification; mass spectrometry; RNA immunoprecipitation; RNA pulldown; immunofluorescence; RNA-protein interaction simulation Molecular cancer Medium 37689715
2023 AP2A1 expression in the orbitofrontal cortex predicts alcohol use disorder severity; prefrontal Ap2a1 expression significantly correlates with voluntary alcohol drinking in genetically diverse mice, and recombinant inbred strains inheriting the C57BL/6J Ap2a1 allele consumed more alcohol than those inheriting the DBA/2J allele, linking AP2A1 to synaptic/presynaptic endocytosis mechanisms governing drinking behavior. Proteomics; machine learning; reverse genetics (mouse strains); gene expression correlation Molecular psychiatry Low 37679472
2023 Radiation-induced ROS accumulation triggers excessive autophagy in NK cells, leading to increased association of the NKG2D receptor with AP2A1, AP2M1, LC3, and lysosomes, resulting in NKG2D endocytosis and lysosomal degradation that impairs NK cell function; this was demonstrated by immunoprecipitation after radiation exposure. Immunoprecipitation; immunofluorescence; Western blot Frontiers in immunology Low 38077388
2025 AP2A1 is upregulated in replicatively senescent human fibroblasts along enlarged actin stress fibers; AP2A1 knockdown reversed senescence-associated phenotypes (rejuvenation), while overexpression in young cells accelerated senescence. AP2A1 co-localizes with integrin β1 and both move linearly along stress fibers, suggesting AP2A1 facilitates integrin β1 translocation to reinforce focal adhesion and anchorage in senescent cells. shRNA knockdown; overexpression; immunofluorescence co-localization; live-cell imaging; proteomics Cellular signalling Medium 39848456
2025 AP2A1 physically interacts with and activates Rab7 (promotes GTP-loading) in neurons, facilitating recruitment of retrograde axonal transport proteins DIC1 and RILP, enhancing retrograde autophagosome transport, restoring autophagic flux, reducing Aβ accumulation, and improving behavioral deficits in Alzheimer's disease models. Co-immunoprecipitation; Rab7 pulldown activation assay; molecular docking; live-cell imaging; immunofluorescence; transmission electron microscopy; Western blot; ELISA; behavioral tests (Morris water maze, open field, object recognition, Y-maze) Alzheimer's research & therapy High 40490761
2025 Ap2a1 binding to membrane μ-opioid receptors (MORs) in paraventricular thalamus (PVT) neurons regulates MOR trafficking (externalization); reduced Ap2a1–MOR binding was associated with increased membrane MOR levels after fentanyl contextual memory retrieval, and conditional knockdown of MOR in PVT demonstrated MOR's contribution to fentanyl contextual memory through modulation of PVT neuronal activity. Co-immunoprecipitation; Western blotting; proteomics; conditional knockdown; chemogenetic manipulation; c-Fos immunofluorescence Acta pharmacologica Sinica Medium 41326807
2025 FMRP associates with AP2A1 mRNA and represses its translation; loss of FMRP in fragile X syndrome models leads to increased steady-state AP2A1 protein levels, enhanced AP-2-dependent endocytosis (including AMPA receptor endocytosis), which is rescued by shRNA downregulation of AP2B1 to wild-type levels. Quantitative mass spectrometry; FMRP RNA binding assay; Western blot; endocytosis functional assay; shRNA rescue iScience Medium 40740492
2025 DNAJC5 interacts with AP2A1 and strengthens AP2A1's interaction with EGFR, promoting EGFR endocytosis and recycling in lung adenocarcinoma cells; knockdown of AP2A1 attenuated DNAJC5-driven EGFR endocytosis and cell proliferation/migration. Co-immunoprecipitation; knockdown experiments; in vitro and in vivo proliferation/migration assays Communications biology Medium 40374748
2026 MDK (Midkine) activates the PI3K/AKT signaling pathway leading to increased AP2A1 expression, which in turn promotes epithelial-mesenchymal transition (EMT) in colorectal cancer cells; PI3K inhibitor LY294002 significantly reduces AP2A1 levels and inhibits MDK-induced malignant behaviors. Western blotting; PI3K inhibitor treatment; overexpression/knockdown; in vitro and in vivo functional assays Cancers Medium 42073635

Source papers

Stage 0 corpus · 34 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2014 Inhibition of autophagy as a new means of improving chemotherapy efficiency in high-LC3B triple-negative breast cancers. Autophagy 147 25427136
2020 Pan-cancer analysis of advanced patient tumors reveals interactions between therapy and genomic landscapes. Nature cancer 127 35121966
2010 The essential role of clathrin-mediated endocytosis in the infectious entry of human enterovirus 71. The Journal of biological chemistry 123 20956521
2021 AP2M1 mediates autophagy-induced CLDN2 (claudin 2) degradation through endocytosis and interaction with LC3 and reduces intestinal epithelial tight junction permeability. Autophagy 78 34964704
2017 Purification and Characterization of Schwann Cells from Adult Human Skin and Nerve. eNeuro 50 28512649
2017 Single Event Resolution of Plant Plasma Membrane Protein Endocytosis by TIRF Microscopy. Frontiers in plant science 33 28484480
2023 circEIF3I facilitates the recruitment of SMAD3 to early endosomes to promote TGF-β signalling pathway-mediated activation of MMPs in pancreatic cancer. Molecular cancer 31 37689715
2018 Ectopic activation of cortical cell division during the accommodation of arbuscular mycorrhizal fungi. The New phytologist 30 30152051
2021 MYO1F regulates antifungal immunity by regulating acetylation of microtubules. Proceedings of the National Academy of Sciences of the United States of America 25 34301894
2016 Utilising the EGFR interactome to identify mechanisms of drug resistance in non-small cell lung cancer - Proof of concept towards a systems pharmacology approach. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 21 27112992
2016 Proteome Analysis of Potential Synaptic Vesicle Cycle Biomarkers in the Cerebrospinal Fluid of Patients with Sporadic Creutzfeldt-Jakob Disease. Molecular neurobiology 21 27562179
2006 Expression of the adaptor protein m-Numb in mouse male germ cells. Reproduction (Cambridge, England) 20 17127749
2024 Proteomic characterization of hUC-MSC extracellular vesicles and evaluation of its therapeutic potential to treat Alzheimer's disease. Scientific reports 17 38472335
2021 Alpha adaptins show isoform-specific association with neurofibrillary tangles in Alzheimer's disease. Neuropathology and applied neurobiology 15 34820873
2020 Flotillin and AP2A1/2 Promote IGF-1 Receptor Association with Clathrin and Internalization in Primary Human Keratinocytes. The Journal of investigative dermatology 14 32027876
2020 Entry of Epidemic Keratoconjunctivitis-Associated Human Adenovirus Type 37 in Human Corneal Epithelial Cells. Investigative ophthalmology & visual science 13 32852546
2016 Identification of novel genes and networks governing hematopoietic stem cell development. EMBO reports 11 27797851
2023 Adaptor protein complex 2 in the orbitofrontal cortex predicts alcohol use disorder. Molecular psychiatry 10 37679472
2018 Molecular cloning of novel transcripts of the adaptor-related protein complex 2 alpha 1 subunit (AP2A1) gene, using Next-Generation Sequencing. Gene 10 30081190
2020 Full-length IL-33 regulates Smad3 phosphorylation and gene transcription in a distinctive AP2-dependent manner. Cellular immunology 9 32977155
2023 Autophagy-mediated NKG2D internalization impairs NK cell function and exacerbates radiation pneumonitis. Frontiers in immunology 8 38077388
2025 AP2A1 modulates cell states between senescence and rejuvenation. Cellular signalling 4 39848456
2025 AP2A1 activates Rab7 to promote axonal autophagosome transport and slow the progression of Alzheimer's disease. Alzheimer's research & therapy 4 40490761
2024 A clathrin mediated endocytosis scaffolding protein, Intersectin 1, changes in an isoform, brain region, and sex specific manner in Alzheimer's disease. Frontiers in neuroscience 4 38915309
2023 Genomic Fabrics of the Excretory System's Functional Pathways Remodeled in Clear Cell Renal Cell Carcinoma. Current issues in molecular biology 4 38132440
2025 Adapter protein 2-modulated -opioid receptor trafficking in paraventricular thalamus contributes to fentanyl contextual addiction memory in mice. Acta pharmacologica Sinica 3 41326807
2025 Potential mechanisms of epigenetic regulation in diabetic retinopathy from the perspectives of multi-omics. Diabetology & metabolic syndrome 2 40369608
2025 FMRP-dependent translational control negatively regulates adapter protein complex 2-mediated endocytosis. iScience 2 40740492
2025 DNAJC5 facilitates the proliferation and migration of lung adenocarcinoma cells by augmenting EGFR trafficking. Communications biology 1 40374748
2024 Accumulation of mutations in the AP2 homoeologs causes suppression of anther extrusion with altered spike and culm development in hexaploid wheat. Molecular breeding : new strategies in plant improvement 1 38404719
2026 MDK Activates the PI3K/AKT Axis to Induce AP2A1 Expression and Epithelial-Mesenchymal Transition in Colorectal Cancer. Cancers 0 42073635
2026 Scale drop disease virus enters Asian seabass kidney cells via clathrin-mediated endocytosis in a cholesterol- and dynamin-dependent manner. Fish & shellfish immunology 0 42173264
2024 Protein Dynamic Landscape of Pig Embryos during Peri-Implantation Development. Journal of proteome research 0 38227546
2023 Adaptor protein complex 2 in the orbitofrontal cortex predicts alcohol use disorder. bioRxiv : the preprint server for biology 0 37398482

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