Affinage

ANKHD1

Ankyrin repeat and KH domain-containing protein 1 · UniProt Q8IWZ3

Length
2542 aa
Mass
269.5 kDa
Annotated
2026-04-28
100 papers in source corpus 20 papers cited in narrative 19 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ANKHD1 is a large, multi-domain scaffolding protein that functions as a transcriptional cofactor in the Hippo/YAP pathway, a membrane-deforming regulator of endosomal trafficking, and an RNA-binding modulator of gene expression, collectively promoting cell proliferation and survival. Its ankyrin repeat domain dimerizes and deforms membranes via a BAR domain-like mechanism to regulate early endosome size, while also modulating microtubule stability and adherens junction organization (PMID:31255983, PMID:34553767, PMID:32464117). ANKHD1 complexes with YAP/Yki on target-gene promoters to drive transcription of cell-cycle genes, directly represses the p21 promoter, and binds tumor-suppressive miRNAs and the lncRNA MALAT1 through its KH domain to further amplify proliferative signaling (PMID:23333314, PMID:25483783, PMID:29695508, PMID:35110552). Additionally, ANKHD1 positively regulates JAK/STAT signaling by stabilizing cytokine receptor levels, promotes autophagy through V-ATPase upregulation, and negatively regulates Parkin recruitment to mitochondria (PMID:29848658, PMID:28806139, PMID:25743185).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 2005 Medium

    The initial characterization of a cytoplasmic ANKHD1 splice variant (VBARP) established that the gene product has an anti-apoptotic function mediated through caspase regulation, providing the first functional link to cell survival.

    Evidence siRNA knockdown with caspase assays and subcellular fractionation in human cells

    PMID:16098192

    Open questions at the time
    • Only a splice variant studied; full-length ANKHD1 function not addressed
    • Mechanism of caspase regulation not defined
  2. 2006 Medium

    Detection of ANKHD1 in cytosolic and membrane fractions and its co-immunoprecipitation with the phosphatase SHP2 suggested a scaffolding role, opening the question of which signaling pathways ANKHD1 organizes.

    Evidence Subcellular fractionation and co-immunoprecipitation in K562 and LNCaP cells

    PMID:16956752

    Open questions at the time
    • SHP2 interaction not validated by reciprocal pull-down or in vivo methods
    • Functional consequence of ANKHD1–SHP2 interaction not demonstrated
  3. 2012 Medium

    ANKHD1 knockdown in multiple myeloma cells revealed its requirement for proliferation and S-to-G2/M progression, with p21 upregulation as a key downstream event independent of p53, establishing ANKHD1 as a cell-cycle regulator.

    Evidence Lentiviral shRNA knockdown, flow cytometry, Western blot in multiple myeloma lines

    PMID:23142581

    Open questions at the time
    • Mechanism of p21 regulation (direct vs. indirect) not yet resolved
    • Limited to myeloma cell lines
  4. 2013 High

    Two independent studies demonstrated that Drosophila Mask/human ANKHD1 complexes with Yki/YAP on target-gene promoters and is essential for Yki/YAP transcriptional activity and tissue growth, definitively placing ANKHD1 as a Hippo pathway cofactor.

    Evidence Genome-wide RNAi screens in Drosophila, co-immunoprecipitation, in vivo Drosophila genetics, human cell complementation

    PMID:23333314 PMID:23333315

    Open questions at the time
    • Structural basis of ANKHD1–YAP interaction not resolved
    • Whether ANKHD1 contributes YAP-independent transcriptional activity unclear
  5. 2014 Medium

    Three studies extended ANKHD1 function: it directly represses the p21 promoter (ChIP-validated), interacts with the pro-apoptotic protein SIVA to regulate Stathmin 1 and migration, and its knockdown in prostate cancer reduces YAP1 expression and xenograft growth, solidifying its oncogenic role across cancer types.

    Evidence ChIP, luciferase reporter, co-IP, yeast two-hybrid, shRNA knockdown, xenograft models in myeloma, leukemia, and prostate cancer cells

    PMID:24726915 PMID:25483783 PMID:25523139

    Open questions at the time
    • Whether p21 repression is YAP-dependent or a parallel mechanism unclear
    • SIVA interaction domain on ANKHD1 not mapped
  6. 2015 High

    Genetic studies in Drosophila showed that loss of Mask rescues pink1/parkin mutant phenotypes and that Mask negatively regulates Parkin recruitment to mitochondria in an autophagy-dependent manner, linking ANKHD1 to mitophagy regulation.

    Evidence Drosophila loss-of-function genetics in pink1/parkin backgrounds, mitochondrial morphology imaging, Parkin recruitment and autophagosome co-localization assays

    PMID:25743185

    Open questions at the time
    • Mechanism by which Mask inhibits Parkin recruitment not molecularly defined
    • Not confirmed in mammalian systems
  7. 2017 High

    Two discoveries revealed that Mask promotes autophagy by upregulating V-ATPase expression (TFEB-independent) to enhance lysosomal function, and that Mask is itself a target of miR-285 in a double-negative feedback loop controlling Yki activity in glia, demonstrating tissue-specific regulation of and by ANKHD1.

    Evidence Drosophila gain/loss-of-function genetics, autophagy flux and lysosome acidification assays, luciferase reporter for miR-285 targeting, genetic epistasis

    PMID:28265104 PMID:28806139

    Open questions at the time
    • Transcription factor mediating Mask-dependent V-ATPase expression unknown
    • Whether the miR-285–Mask loop is conserved in mammals not tested
  8. 2018 High

    ANKHD1's KH domain was shown to bind tumor-suppressive miRNAs (miR-29a, miR-205, miR-196a), suppressing their function to upregulate Cyclin D1 in renal carcinoma; separately, ANKHD1 was identified as a positive regulator of JAK/STAT signaling by stabilizing cytokine receptor levels in both Drosophila and human cells.

    Evidence RNA-immunoprecipitation for miRNA binding, genome-wide RNAi screen for JAK/STAT, receptor dimerization and level assays, knockdown in human cells

    PMID:29695508 PMID:29848658 PMID:30555746

    Open questions at the time
    • Specificity of KH domain for particular miRNAs vs. broader RNA targets not fully defined
    • Whether JAK/STAT regulation occurs through membrane-shaping activity or a distinct mechanism unclear
  9. 2019 High

    Reconstitution experiments demonstrated that the ANKHD1 ankyrin repeat domain dimerizes and its C-terminal repeats deform membranes into tubules via an amphipathic helix and curved surface analogous to BAR domains, establishing ANKHD1 as a membrane-shaping protein that restricts early endosome size.

    Evidence In vitro membrane deformation assay, domain-deletion structural analysis, ANKHD1 knockdown with endosome imaging

    PMID:31255983

    Open questions at the time
    • No high-resolution structure of the ARD in the membrane-bound state
    • Cargo specificity of ANKHD1-mediated endosomal trafficking unknown
  10. 2020 Medium

    ANKHD1 was found to regulate lncRNA LINC00346 stability and to participate in STAU1-mediated mRNA decay of ZNF655 in a feedback loop promoting glioma angiogenesis, and separately to control adherens junction distribution and cytoskeletal gene expression during Drosophila eye morphogenesis.

    Evidence RIP, RNA pulldown, ChIP, shRNA knockdown, in vivo angiogenesis assays; Drosophila genetics, RNA-seq, confocal imaging

    PMID:32464117 PMID:32464549

    Open questions at the time
    • LINC00346 findings from single study, not independently replicated
    • Whether morphogenetic roles require membrane-deforming activity not tested
  11. 2021 Medium

    The ANKHD1 N-terminal ankyrin repeats were shown to negatively regulate microtubule stability and the MT-associated protein Jupiter in Drosophila neurons and muscles, with genetic interaction with Stathmin; separately, SMYD3 was found to promote cisplatin resistance through physical interaction with ANKHD1.

    Evidence Drosophila domain-deletion genetics, MT polymer measurements, NMJ imaging; co-IP and co-localization in NSCLC cells, xenograft epistasis

    PMID:33773404 PMID:34553767

    Open questions at the time
    • Direct biochemical mechanism of MT destabilization by ANKHD1 not established
    • SMYD3–ANKHD1 interface and whether SMYD3 methylates ANKHD1 unknown
  12. 2022 Medium

    ANKHD1 was shown to bind lncRNA MALAT1 and form a feedback loop with YAP1 that enhances YAP1 transcriptional coactivation and radioresistance in colorectal cancer via the YAP1/AKT axis, adding RNA-scaffolded amplification to its Hippo pathway cofactor role.

    Evidence RIP, RNA pulldown, shRNA knockdown, in vitro and in vivo irradiation assays in colorectal cancer models

    PMID:35110552

    Open questions at the time
    • Structural basis of MALAT1–ANKHD1 interaction not defined
    • Whether MALAT1 binding is KH-domain-dependent not tested

Open questions

Synthesis pass · forward-looking unresolved questions
  • Major unresolved questions include: the structural basis for ANKHD1's selective engagement with YAP versus other partners, whether the membrane-deforming and transcriptional cofactor functions are coordinated or independent, the identity of direct substrates or targets of ANKHD1's RNA-binding KH domain genome-wide, and whether the mitophagy and V-ATPase regulatory functions observed in Drosophila are conserved in mammals.
  • No high-resolution structure of full-length ANKHD1 or its domain complexes
  • Genome-wide RNA target profiling (CLIP-seq) not performed
  • Mammalian validation of autophagy/mitophagy functions lacking

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 3 GO:0060090 molecular adaptor activity 3 GO:0140110 transcription regulator activity 2 GO:0008289 lipid binding 1
Localization
GO:0005829 cytosol 2 GO:0005886 plasma membrane 2 GO:0005634 nucleus 1 GO:0005768 endosome 1
Pathway
R-HSA-162582 Signal Transduction 5 R-HSA-1640170 Cell Cycle 3 R-HSA-9612973 Autophagy 2 R-HSA-5357801 Programmed Cell Death 1 R-HSA-5653656 Vesicle-mediated transport 1
Partners
MALAT1SHP2SIVA1SMYD3STMN1YAP1

Evidence

Reading pass · 19 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2013 Drosophila Mask (ANKHD1 ortholog) forms a complex with Yorkie (Yki) and its binding partner Scalloped (Sd) on target-gene promoters and is essential for Yki to drive transcription of target genes and tissue growth; the human homolog ANKHD1 (MASK1) complexes with YAP and is required for full YAP activity. Genome-wide RNAi screen in Drosophila S2 cells, co-immunoprecipitation, in vivo Drosophila genetics, human cell complementation Current biology : CB High 23333314 23333315
2006 ANKHD1 protein is detected in the cytosolic and membrane fraction of cells and co-immunoprecipitates with SHP2 in K562 and LNCaP cell lines, suggesting a role as a scaffolding protein. Subcellular fractionation, co-immunoprecipitation Biochimica et biophysica acta Medium 16956752
2014 ANKHD1 silencing in prostate cancer cells decreases YAP1 expression and activation, reduces CCNA2 (Cyclin A) expression, delays cell cycle progression at S phase, and suppresses tumor xenograft growth, identifying ANKHD1 as a positive regulator of YAP1 in the Hippo pathway. shRNA knockdown, flow cytometry, xenograft mouse model, Western blot Experimental cell research Medium 24726915
2012 ANKHD1 is highly expressed in multiple myeloma cells; lentiviral shRNA-mediated ANKHD1 silencing inhibits proliferation, delays S-to-G2M cell cycle progression, and upregulates the CDK inhibitor p21 regardless of p53 status. Lentiviral shRNA knockdown, flow cytometry, Western blot FEBS letters Medium 23142581
2014 ANKHD1 interacts with SIVA (pro-apoptotic protein) via co-immunoprecipitation; ANKHD1 silencing leads to Stathmin 1 inactivation, reduced cell migration and xenograft tumor growth, likely by inhibiting the SIVA/Stathmin 1 association, while ANKHD1 promotes leukemia cell proliferation and migration through the Stathmin 1 pathway. Yeast two-hybrid screen, co-immunoprecipitation, lentiviral shRNA knockdown, xenograft mouse model Biochimica et biophysica acta Medium 25523139
2014 ANKHD1 directly represses the p21 promoter (confirmed by ChIP and luciferase assay) and co-immunoprecipitates with p21 in multiple myeloma cells; ANKHD1 shuttles between cytoplasm and nucleus (nuclear accumulation upon Leptomycin B treatment). Co-immunoprecipitation, chromatin immunoprecipitation (ChIP), luciferase reporter assay, confocal microscopy with Leptomycin B treatment European journal of cancer (Oxford, England : 1990) Medium 25483783
2005 A splice variant of ANKHD1 lacking the KH domain (VBARP) is primarily localized in the cytoplasm; siRNA knockdown demonstrates it is essential for cell survival through regulation of caspases, indicating an anti-apoptotic function. siRNA knockdown, subcellular fractionation, caspase assays, immunofluorescence The FEBS journal Medium 16098192
2018 ANKHD1 binds to tumor-suppressing miRNAs (miR-29a, miR-205, miR-196a) via its KH domain (confirmed by RNA-immunoprecipitation); ANKHD1 suppresses these miRNAs to drive renal cell carcinoma proliferation by upregulating CCND1. RNA-immunoprecipitation, bioinformatics, siRNA knockdown, cell cycle analysis, quantitative PCR The Journal of biological chemistry Medium 29695508
2019 The ankyrin repeat domain (ARD) of ANKHD1 dimerizes; the first 15 ankyrin repeats mediate dimerization and the latter 10 ankyrin repeats deform membranes into tubules and vesicles via an adjacent amphipathic helix and curved positively-charged surface analogous to BAR domains. ANKHD1 knockdown revealed its role in negative regulation of early endosome enlargement. In vitro membrane deformation assay, structural/domain analysis, co-immunoprecipitation for dimerization, ANKHD1 knockdown with endosome imaging iScience High 31255983
2018 Drosophila MASK (ANKHD1 ortholog) is identified as a positive regulator of Domeless (cytokine receptor) dimerization and protein levels in a genome-wide RNAi screen; human ANKHD1 similarly regulates JAK/STAT signaling and levels of a subset of cytokine receptors in human cells. Genome-wide RNAi screen, JAK/STAT reporter assay, receptor dimerization assay, ANKHD1 knockdown in human cells Journal of cell science High 29848658
2017 In Drosophila, Mask (ANKHD1 ortholog) is directly targeted by miR-285 to suppress Yorkie (Yki) activity and downregulate cyclin E expression in subperineurial glia; this miR-285–Yki/Mask double-negative feedback loop maintains appropriate subperineurial glia ploidy and blood-brain barrier integrity. Luciferase reporter assay for miR-285 targeting of Mask, genetic epistasis, loss-of-function and gain-of-function in Drosophila, cyclin E expression analysis Proceedings of the National Academy of Sciences of the United States of America High 28265104
2017 Mask (ANKHD1 ortholog) promotes autophagy flux by enhancing lysosomal function and is necessary and sufficient for promoting expression of vacuolar (V)-type ATPases in a TFEB-independent manner; loss of Mask function worsens, and gain of Mask function mitigates, degeneration caused by MAPT/TAU or FUS protein aggregation in Drosophila models. Drosophila eye and muscle models (loss- and gain-of-function genetics), autophagy flux assays, lysosome acidification assays, V-ATPase expression analysis, epistasis with autophagy pathway mutants Autophagy High 28806139
2015 Loss of Mask (ANKHD1 ortholog) function rescues mitochondrial and behavioral defects in Drosophila pink1 and parkin mutants; Mask genetically interacts with Parkin to modulate mitochondrial morphology and negatively regulates Parkin recruitment to mitochondria; an intact autophagy pathway is required for this rescue. Drosophila genetics (loss-of-function mask in pink1/parkin mutant backgrounds), mitochondrial morphology imaging, Parkin recruitment assay, autophagosome co-localization, epistasis with autophagy mutants Human molecular genetics High 25743185
2021 Mask (ANKHD1 ortholog) negatively affects microtubule (MT) stability in Drosophila larval muscles and motor neurons; the ankyrin repeat-containing N-terminal domain is sufficient for this effect; Mask negatively regulates the MT-associated protein Jupiter in motor neuron axons; mask genetically interacts with stathmin in regulation of axon transport and synaptic terminal stability. Drosophila loss-of-function genetics, MT polymer length measurement, neuromuscular junction imaging, structure-function domain deletion analysis, genetic epistasis with stathmin and Jupiter Journal of cell science High 34553767
2018 ANKHD1 silencing in colorectal cancer cells reduces YAP1 expression and increases YAP1 phosphorylation, inhibits AKT signaling, and suppresses EMT markers (MMP2, MMP9, vimentin, Snail, ZEB1) while increasing E-cadherin; YAP1 overexpression reverses ANKHD1 knockdown effects, placing ANKHD1 upstream of YAP1/AKT/EMT. shRNA knockdown, YAP1 rescue overexpression, Western blot, in vitro migration/invasion assays, in vivo xenograft American journal of cancer research Medium 30555746
2021 SMYD3 promotes cisplatin resistance in NSCLC in an ANKHD1-dependent manner; SMYD3 and ANKHD1 physically interact (co-immunoprecipitation and co-localization by immunofluorescence); SMYD3 transcriptionally regulates CDK2 via its promoter (ChIP); ANKHD1 overexpression abolishes the sensitizing effect of SMYD3 knockdown in vivo. Co-immunoprecipitation, immunofluorescence co-localization, chromatin immunoprecipitation (ChIP), shRNA knockdown, xenograft mouse model Translational oncology Medium 33773404
2020 ANKHD1 targets lncRNA LINC00346 and enhances its stability; LINC00346 binds ZNF655 mRNA via Alu elements and facilitates its degradation via STAU1-mediated mRNA decay; ZNF655 targets the ANKHD1 promoter, forming a feedback loop that regulates glioma angiogenesis. RIP (RNA immunoprecipitation), RNA pulldown, reporter assay, ChIP, shRNA knockdown, in vivo angiogenesis assays Molecular therapy. Nucleic acids Medium 32464549
2022 ANKHD1 and lncRNA MALAT1 interact (confirmed by RIP and RNA pulldown); ANKHD1/MALAT1/YAP1 form a feedback loop that promotes YAP1 transcriptional coactivation and enhances radioresistance of colorectal cancer via the YAP1/AKT axis. RNA immunoprecipitation (RIP), RNA pulldown, shRNA knockdown, in vitro and in vivo irradiation assays, Western blot Cell death & disease Medium 35110552
2020 Mask (ANKHD1 ortholog) is required for correct distribution and accumulation of adherens junctions and appropriate cytoskeletal organization during Drosophila pupal eye morphogenesis; RNA-sequencing revealed Mask regulates expression of cell adhesion, cytoskeletal, cell survival, and signal transduction genes; FER and Vinc are validated downstream targets. Drosophila loss-of-function genetics, RNA-sequencing, confocal imaging of adherens junctions and cytoskeleton, genetic epistasis with Hippo pathway and downstream targets Developmental biology Medium 32464117

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2006 A fast and symmetric DUST implementation to mask low-complexity DNA sequences. Journal of computational biology : a journal of computational molecular cell biology 356 16796549
2002 Beyond the iron mask: towards better recognition and treatment of depression associated with Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society 150 12112190
2015 MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): the new generation guideline implementation. Allergy 135 26148220
2010 Extracellular water may mask actual muscle atrophy during aging. The journals of gerontology. Series A, Biological sciences and medical sciences 128 20133393
2012 Early presynaptic and postsynaptic calcium signaling abnormalities mask underlying synaptic depression in presymptomatic Alzheimer's disease mice. The Journal of neuroscience : the official journal of the Society for Neuroscience 111 22699914
2020 Wearing a face mask against Covid-19 results in a reduction of social distancing. PloS one 89 33284812
2013 Strategies of highly pathogenic RNA viruses to block dsRNA detection by RIG-I-like receptors: hide, mask, hit. Antiviral research 81 24129118
2013 Mask is required for the activity of the Hippo pathway effector Yki/YAP. Current biology : CB 74 23333314
2017 Pilot study of mobile phone technology in allergic rhinitis in European countries: the MASK-rhinitis study. Allergy 72 28072463
2017 Work productivity in rhinitis using cell phones: The MASK pilot study. Allergy 68 28387952
2007 Analysis of nucleotides by pressure-assisted capillary electrophoresis-mass spectrometry using silanol mask technique. Journal of chromatography. A 68 17543971
1994 Histidine-rich glycoprotein and platelet factor 4 mask heparan sulfate proteoglycans recognized by acidic and basic fibroblast growth factor. Biochemistry 67 7524669
2013 Mask proteins are cofactors of Yorkie/YAP in the Hippo pathway. Current biology : CB 66 23333315
2020 Pervasive head-to-tail insertions of DNA templates mask desired CRISPR-Cas9-mediated genome editing events. Science advances 58 32095517
2016 Removing Orientation-Induced Localization Biases in Single-Molecule Microscopy Using a Broadband Metasurface Mask. Nature photonics 52 27574529
2001 Cloning of MASK, a novel member of the mammalian germinal center kinase III subfamily, with apoptosis-inducing properties. The Journal of biological chemistry 52 11741893
2016 Skeletal muscle atrophy: disease-induced mechanisms may mask disuse atrophy. Journal of muscle research and cell motility 49 26728748
2003 MC1R studies in dogs with melanistic mask or brindle patterns. The Journal of heredity 48 12692165
2022 How does the presence of a surgical face mask impair the perceived intensity of facial emotions? PloS one 46 35025948
2020 Effect of various decontamination procedures on disposable N95 mask integrity and SARS-CoV-2 infectivity. Journal of clinical and translational science 46 34192045
2019 Light-addressable electrochemistry at semiconductor electrodes: redox imaging, mask-free lithography and spatially resolved chemical and biological sensing. Chemical Society reviews 46 31143897
2014 ANKHD1, a novel component of the Hippo signaling pathway, promotes YAP1 activation and cell cycle progression in prostate cancer cells. Experimental cell research 43 24726915
2022 Mechanosensitive brain tumor cells construct blood-tumor barrier to mask chemosensitivity. Neuron 42 36323321
2021 Exhaled SARS-CoV-2 quantified by face-mask sampling in hospitalised patients with COVID-19. The Journal of infection 42 33774019
2022 scNAME: neighborhood contrastive clustering with ancillary mask estimation for scRNA-seq data. Bioinformatics (Oxford, England) 41 34999761
2022 DeepTrio: a ternary prediction system for protein-protein interaction using mask multiple parallel convolutional neural networks. Bioinformatics (Oxford, England) 40 34694333
2012 The evolutionary history of the Arabidopsis arenosa complex: diverse tetraploids mask the Western Carpathian center of species and genetic diversity. PloS one 37 22880083
2020 Role of ANKHD1/LINC00346/ZNF655 Feedback Loop in Regulating the Glioma Angiogenesis via Staufen1-Mediated mRNA Decay. Molecular therapy. Nucleic acids 36 32464549
2006 ANKHD1, ankyrin repeat and KH domain containing 1, is overexpressed in acute leukemias and is associated with SHP2 in K562 cells. Biochimica et biophysica acta 35 16956752
2016 DNA Origami Mask for Sub-Ten-Nanometer Lithography. ACS nano 34 27281227
2017 miR-285-Yki/Mask double-negative feedback loop mediates blood-brain barrier integrity in Drosophila. Proceedings of the National Academy of Sciences of the United States of America 33 28265104
2022 The feedback loop of ANKHD1/lncRNA MALAT1/YAP1 strengthens the radioresistance of CRC by activating YAP1/AKT signaling. Cell death & disease 32 35110552
2021 A deep learning approach to the screening of malaria infection: Automated and rapid cell counting, object detection and instance segmentation using Mask R-CNN. Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society 32 33582593
2021 COVID-19 mask waste to energy via thermochemical pathway: Effect of Co-Feeding food waste. Energy (Oxford, England) 30 33994654
2024 Sprayable biomimetic double mask with rapid autophasing and hierarchical programming for scarless wound healing. Science advances 29 39141725
2021 Cotton and Surgical Face Masks in Community Settings: Bacterial Contamination and Face Mask Hygiene. Frontiers in medicine 29 34540873
2012 ANKHD1 regulates cell cycle progression and proliferation in multiple myeloma cells. FEBS letters 29 23142581
2010 CpG methylation in neurons: message, memory, or mask? Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 29 20631690
2017 Mask mitigates MAPT- and FUS-induced degeneration by enhancing autophagy through lysosomal acidification. Autophagy 26 28806139
2014 ANKHD1 silencing inhibits Stathmin 1 activity, cell proliferation and migration of leukemia cells. Biochimica et biophysica acta 26 25523139
2009 T-cell epitope prediction: rescaling can mask biological variation between MHC molecules. PLoS computational biology 26 19300484
2022 Preparation and characterization of electrospun nanofibers-based facial mask containing hyaluronic acid as a moisturizing component and huangshui polysaccharide as an antioxidant component. International journal of biological macromolecules 25 35709871
2018 Ankyrin repeat and single KH domain 1 (ANKHD1) drives renal cancer cell proliferation via binding to and altering a subset of miRNAs. The Journal of biological chemistry 25 29695508
2005 Cell patterning on biological gels via cell spraying through a mask. Tissue engineering 24 15998211
2022 Unraveling the dynamics of the Omicron and Delta variants of the 2019 coronavirus in the presence of vaccination, mask usage, and antiviral treatment. Applied mathematical modelling 23 36281307
2015 Mask loss-of-function rescues mitochondrial impairment and muscle degeneration of Drosophila pink1 and parkin mutants. Human molecular genetics 23 25743185
2014 ANKHD1 represses p21 (WAF1/CIP1) promoter and promotes multiple myeloma cell growth. European journal of cancer (Oxford, England : 1990) 23 25483783
2021 Susceptible trichostrongyloid species mask presence of benzimidazole-resistant Haemonchus contortus in cattle. Parasites & vectors 22 33557939
2018 Under the mask of Kabuki syndrome: Elucidation of genetic-and phenotypic heterogeneity in patients with Kabuki-like phenotype. European journal of medical genetics 21 29307790
2012 Pituitary stem cells drop their mask. Current stem cell research & therapy 21 22023621
2018 ANKHD1 silencing suppresses the proliferation, migration and invasion of CRC cells by inhibiting YAP1-induced activation of EMT. American journal of cancer research 19 30555746
2017 Mask-free fabrication of a versatile microwell chip for multidimensional cellular analysis and drug screening. Lab on a chip 18 29152631
2005 Molecular and functional characterization of a novel splice variant of ANKHD1 that lacks the KH domain and its role in cell survival and apoptosis. The FEBS journal 17 16098192
2023 Mask and Release Strategy-Enabled Diversity-Oriented Synthesis for DNA-Encoded Library. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 16 38044314
2022 Comparison Between Heated Eye Mask and Intense Pulsed Light Treatment for Contact Lens-Related Dry Eye. Photobiomodulation, photomedicine, and laser surgery 16 35298282
2021 Non-invasive adapted N-95 mask sampling captures variation in viral particles expelled by COVID-19 patients: Implications in understanding SARS-CoV2 transmission. PloS one 16 33844696
2021 A novel identified circ-ANKHD1 targets the miR-27a-3p/SFRP1 signaling pathway and modulates the apoptosis of granulosa cells. Environmental science and pollution research international 15 34091845
2020 Diagnosis of pharyngeal cancer on endoscopic video images by Mask region-based convolutional neural network. Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society 15 32715508
2019 Membrane-Deformation Ability of ANKHD1 Is Involved in the Early Endosome Enlargement. iScience 15 31255983
2018 A genome-wide RNAi screen identifies MASK as a positive regulator of cytokine receptor stability. Journal of cell science 15 29848658
2023 Phthalate acid esters contribute to the cytotoxicity of mask leachate: Cell-based assay for toxicity assessment. Journal of hazardous materials 14 37494796
2023 Physiological responses and molecular mechanism of Chlorella sorokiniana to surgical mask exudates in wastewater. Journal of hazardous materials 13 37939560
2022 Effects of wearing a transparent face mask on perception of facial expressions. i-Perception 13 35782828
2022 When Is It Appropriate to Take Off the Mask? Signaling Pathways That Regulate ß(1,3)-Glucan Exposure in Candida albicans. Frontiers in fungal biology 13 36908584
2018 Artefactual band patterns by SDS-PAGE of the Vip3Af protein in the presence of proteases mask the extremely high stability of this protein. International journal of biological macromolecules 13 30120972
2023 Inflammation and comorbidities of chronic obstructive pulmonary disease: The cytokines put on a mask! Cytokine 12 37922621
2022 Incomplete lineage sorting and reticulate evolution mask species relationships in Brunelliaceae, an Andean family with rapid, recent diversification. American journal of botany 12 35709353
2021 Mask, the Drosophila ankyrin repeat and KH domain-containing protein, affects microtubule stability. Journal of cell science 12 34553767
2019 Conserved numts mask a highly divergent mitochondrial-COI gene in a species complex of Australian stingless bees Tetragonula (Hymenoptera: Apidae). Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis 12 31526165
2023 Emotional face recognition when a colored mask is worn: a cross-sectional study. Scientific reports 11 36599964
2023 Antibiotic resistomes in face-mask biofilm along an urban river: Multiple drivers and co-occurrence with human opportunistic pathogens. Journal of hazardous materials 11 37172383
2022 Collection and detection of SARS-CoV-2 in exhaled breath using face mask. PloS one 11 35980889
2022 Keep Your Mask On: The Benefits of Masking for Behavior and the Contributions of Aging and Disease on Dysfunctional Masking Pathways. Frontiers in neuroscience 11 36017187
2014 Who's behind that mask and cape? The Asian leopard cat's Agouti (ASIP) allele likely affects coat colour phenotype in the Bengal cat breed. Animal genetics 11 25143047
2009 Fabrication of antireflective sub-wavelength structures on silicon nitride using nano cluster mask for solar cell application. Nanoscale research letters 11 20596409
2023 Impact of disposable mask microplastics pollution on the aquatic environment and microalgae growth. Environmental science and pollution research international 10 37256394
2022 Noise reduction and mask removal neural network for X-ray single-particle imaging. Journal of applied crystallography 10 35145358
2022 Enzymatic biofuel cell-powered iontophoretic facial mask for enhanced transdermal drug delivery. Biosensors & bioelectronics 10 36563525
2020 Emerging functions for ANKHD1 in cancer-related signaling pathways and cellular processes. BMB reports 10 32635985
2023 RefinePocket: An Attention-Enhanced and Mask-Guided Deep Learning Approach for Protein Binding Site Prediction. IEEE/ACM transactions on computational biology and bioinformatics 9 37040253
2022 Full-Face Mask Use during SCUBA Diving Counters Related Oxidative Stress and Endothelial Dysfunction. International journal of environmental research and public health 9 35055791
2021 SMYD3 confers cisplatin chemoresistance of NSCLC cells in an ANKHD1-dependent manner. Translational oncology 9 33773404
2021 Matriptase-2 and Hemojuvelin in Hepcidin Regulation: In Vivo Immunoblot Studies in Mask Mice. International journal of molecular sciences 9 33800732
2021 Application of green synthesised copper iodide particles on cotton fabric-protective face mask material against COVID-19 pandemic. Journal of materials research and technology 9 35864980
2020 Mask, a component of the Hippo pathway, is required for Drosophila eye morphogenesis. Developmental biology 9 32464117
2014 Lifting the mask: identification of new small molecule inhibitors of uropathogenic Escherichia coli group 2 capsule biogenesis. PloS one 9 24983234
2008 Three-dimensional architecture of inorganic nanoarrays electrodeposited through a surface-layer protein mask. Nano letters 9 18376869
2024 Whispers in the Wind: Face Mask Sampling for Mycobacterium tuberculosis Detection in Children With Pulmonary Tuberculosis. The Journal of infectious diseases 8 38798080
2023 Face mask derived micro(nano)plastics and organic compounds potentially induce threat to aquatic ecosystem security revealed by toxicogenomics-based assay. Water research 8 37356160
2023 Evaluating the Molecular Properties and Function of ANKHD1, and Its Role in Cancer. International journal of molecular sciences 8 37629022
2022 Facial mask personalization encourages facial mask wearing in times of COVID-19. Scientific reports 8 35042911
2021 Metabolic syndrome cannot mask the changes of faecal microbiota compositions caused by primary hepatocellular carcinoma. Letters in applied microbiology 8 33768575
2019 High glucose concentrations mask cellular phenotypes in a stem cell model of tuberous sclerosis complex. Epilepsy & behavior : E&B 8 31761686
2015 Evaluating time between birth to cry or bag and mask ventilation using mobile delivery room timers in India: the NICHD Global Network's Helping Babies Breathe Trial. BMC pediatrics 8 26245688
2014 Cobalamin deficiency can mask depleted body iron reserves. Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion 8 25825568
2013 Decreased hemojuvelin protein levels in mask mice lacking matriptase-2-dependent proteolytic activity. Physiological research 8 23590607
2000 In COPD patients, body weight excess can mask lean tissue depletion: a simple method of estimation. Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace 8 11057077
2024 Multifunctional FFP2 Face Mask for White Light Disinfection and Pathogens Detection using Hybrid Nanostructures and Optical Metasurfaces. Small (Weinheim an der Bergstrasse, Germany) 7 38742980
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