Affinage

ABCA1

Phospholipid-transporting ATPase ABCA1 · UniProt O95477

Length
2261 aa
Mass
254.3 kDa
Annotated
2026-06-09
100 papers in source corpus 34 papers cited in narrative 32 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ABCA1 is an ATP-hydrolyzing integral membrane transporter that drives the rate-limiting first step of reverse cholesterol transport, exporting cellular cholesterol and phospholipids to lipid-poor apolipoproteins—principally apoA-I—to nucleate nascent HDL particles; loss-of-function mutations cause Tangier disease (PMID:10882340, PMID:11111099, PMID:11483617). The purified protein reconstituted in liposomes hydrolyzes ATP in a manner preferentially stimulated by phosphatidylcholine and sphingomyelin and inhibited by specific sterols, establishing its direct enzymatic mechanism (PMID:16500904), and it operates as an extracellular phospholipid translocase that extracts outer-leaflet phospholipids through a hydrophobic gateway/annulus tunnel in its extracellular domain rather than as an inner-to-outer floppase (PMID:35974019). ABCA1 activity generates two classes of cell-surface apoA-I binding sites—a minor direct ABCA1/apoA-I site and a dominant high-capacity site formed by apoA-I engaging ABCA1-generated lipid domains, the latter requiring the apoA-I C-terminus and driving HDL assembly (PMID:17478755). ApoA-I binding additionally triggers JAK2/STAT3, PKA, PKC, and CDC42 signaling that feeds back on lipid efflux, protein stability, and inflammation (PMID:22064972). The transporter cycles between the plasma membrane and endosomes via clathrin/Rab5-mediated retroendocytosis with Rab4-dependent recycling that contributes to efflux (PMID:19170766), and it partitions into lipid rafts and phagosomes in association with syntaxin 13 and flotillin-1 (PMID:15469992). ABCA1 abundance is tightly controlled transcriptionally—induced by LXR/RXR, RAR, and AMPK–LXRα, and repressed by ORP8, TRAK2, and CXCL12/CXCR4–GSK3β/TCF21 signaling (PMID:14560020, PMID:28655204, PMID:27343431, PMID:31662443)—and post-translationally through calpain-mediated degradation accelerated by PLD2-dependent serine phosphorylation, OSBP, and AGE–RAGE–ubiquitin/lysosomal pathways (PMID:16118212, PMID:18450749, PMID:29097054). Beyond efflux, ABCA1 restrains TLR4-driven macrophage inflammation through membrane lipid remodeling (PMID:19797709), governs beta-cell cholesterol homeostasis and insulin secretion (PMID:17322896, PMID:22315319), directs hepatic HDL assembly and VLDL secretion (PMID:22001232), maintains astrocyte apoE lipidation and neuroinflammatory tone (PMID:23376685), and acts as a myeloid tumor suppressor by limiting IL-3Rβ/MAPK/JAK2 signaling (PMID:32160545).

Mechanistic history

Synthesis pass · year-by-year structured walk · 31 steps
  1. 2000 High

    Established ABCA1 as the molecular cause of defective cellular cholesterol efflux, defining the first step of reverse cholesterol transport and a human disease gene.

    Evidence Genetic linkage and mutation analysis in Tangier disease patients with cellular cholesterol efflux assays

    PMID:10882340 PMID:11111099 PMID:11483617

    Open questions at the time
    • Did not resolve the enzymatic transport mechanism
    • Did not define the lipid substrate or directionality of transport
  2. 2003 High

    Identified retinoic acid receptors as direct transcriptional inducers of ABCA1 acting through the same promoter DR4 element as LXR/RXR, broadening the regulatory inputs controlling efflux capacity.

    Evidence Promoter-reporter cotransfection, ChIP, and RARγ knockout macrophages

    PMID:14560020

    Open questions at the time
    • Did not establish physiological RAR ligand context
    • Crosstalk with LXR occupancy not fully resolved
  3. 2004 High

    Placed ABCA1 in lipid raft microdomains and phagosomes via direct association with syntaxin 13 and flotillin-1, linking it to vesicular lipid transport.

    Evidence Reciprocal co-IP, immunofluorescence, detergent-resistant microdomain fractionation, and syntaxin 13 siRNA

    PMID:15469992

    Open questions at the time
    • Mechanism by which syntaxin 13 stabilizes ABCA1 not defined
    • Phagosomal lipid handling role not quantified
  4. 2005 High

    Defined a post-translational destabilization route in which unsaturated fatty acids drive PLD2-dependent serine phosphorylation and accelerated ABCA1 degradation, connecting lipid metabolism to transporter turnover.

    Evidence PLD inhibitors/activators, PLD2 siRNA, acyl-CoA synthetase inhibition, and phosphorylation/efflux assays

    PMID:16118212

    Open questions at the time
    • Kinase mediating ABCA1 serine phosphorylation not identified
    • Link to calpain degradation pathway not directly tested
  5. 2006 High

    Provided the first direct biochemical proof of ABCA1 enzymatic activity, showing phospholipid-stimulated, sterol-modulated ATPase activity with purified reconstituted protein.

    Evidence Purification from Sf9 cells, liposome reconstitution, in vitro ATPase assays with lipid and pharmacological modulators

    PMID:16500904

    Open questions at the time
    • Did not resolve coupling of ATP hydrolysis to lipid movement
    • Structural basis of sterol inhibition not defined
  6. 2007 High

    Resolved how apoA-I engages the cell surface, distinguishing a minor direct ABCA1-binding site from a dominant ABCA1-generated lipid-domain site responsible for HDL assembly.

    Evidence Radiolabeled apoA-I binding, cross-linking, and apoA-I C-terminal deletion mutants on macrophages

    PMID:17478755

    Open questions at the time
    • Molecular nature of the lipid domain not structurally defined
    • Relative contribution of each site to net efflux not quantified
  7. 2007 High

    Demonstrated a tissue-specific physiological role for ABCA1 in beta-cell cholesterol homeostasis and glucose-stimulated insulin secretion, extending function beyond vascular efflux.

    Evidence Beta-cell-specific Abca1 knockout mice with glucose tolerance and islet insulin secretion assays

    PMID:17322896

    Open questions at the time
    • Did not define how islet cholesterol controls secretion machinery
    • ER ORP8-based transcriptional repression of ABCA1 awaits replication
  8. 2007 Medium

    Identified ER-localized ORP8 as a sterol-sensing negative transcriptional regulator of ABCA1 acting through promoter DR4/E-box elements.

    Evidence ORP8 siRNA in THP-1 macrophages with promoter-luciferase mutagenesis and efflux assays

    PMID:17991739

    Open questions at the time
    • Single lab; transcription factor linking ORP8 to promoter not identified
    • In vivo relevance not established
  9. 2008 High

    Established endosomal cycling as a functional determinant of ABCA1, showing clathrin/Rab5 retroendocytosis with Rab4-dependent recycling that supports efflux from lipid-loaded cells.

    Evidence Dual-tagged ABCA1 constructs, dominant-negative Rab GTPases, and efflux assays

    PMID:19170766

    Open questions at the time
    • Sorting signals directing recycling versus degradation not mapped
    • Fraction of efflux attributable to recycling not generalized across cell types
  10. 2008 High

    Identified OSBP as a sterol-binding-domain-dependent destabilizer of ABCA1 protein, distinct from transcriptional control.

    Evidence OSBP RNAi, cycloheximide-chase half-life measurement, and OSBP domain mutants in CHO and J774 cells

    PMID:18450749

    Open questions at the time
    • Degradation machinery engaged by OSBP not identified
    • Direct OSBP-ABCA1 interaction not demonstrated
  11. 2009 Medium

    Connected ABCA1-mediated efflux to anti-inflammatory function, showing ABCA1 deficiency amplifies TLR4 signaling through membrane lipid organization.

    Evidence ABCA1-deficient macrophages with TLR4 stimulation and cytokine/efflux readouts

    PMID:19797709

    Open questions at the time
    • Precise lipid raft change driving TLR4 sensitization not defined
    • Causal separation of efflux from membrane remodeling incomplete
  12. 2009 Medium

    Defined an upstream signaling axis (LRP1 loss → PDGFRβ/MAPK → cPLA2 → arachidonic acid) that suppresses LXR-driven ABCA1 transcription.

    Evidence LRP1-deficient cells, MAPK inhibitors, cPLA2 phosphorylation, and LXR/RXR reporter and efflux assays

    PMID:19718435

    Open questions at the time
    • Single lab; in vivo validation limited
    • Mechanism of arachidonic acid LXR inhibition not detailed
  13. 2011 Medium

    Established hepatic ABCA1 as essential for HDL assembly and as a regulator of VLDL secretion, linking it via PI3K to lipoprotein metabolism.

    Evidence Hepatocyte-specific ABCA1 KO mice, hepatoma ABCA1 siRNA, lipoprotein profiling, and PI3K activity assays

    PMID:22001232

    Open questions at the time
    • Mechanism coupling ABCA1 to VLDL size control not resolved
    • PI3K-ABCA1 connection not biochemically defined
  14. 2012 Medium

    Showed that apoA-I/ABCA1 engagement activates JAK2/STAT3, PKA, PKC, and CDC42 signaling that feeds back on efflux, ABCA1 stability, and inflammation, casting ABCA1 as a signaling receptor.

    Evidence Pharmacological and genetic kinase modulation with efflux, stability, and inflammatory readouts (integrative study)

    PMID:22064972

    Open questions at the time
    • Direct coupling of ABCA1 to each kinase not structurally mapped
    • Quantitative contribution of signaling versus transport to function unclear
  15. 2012 High

    Identified miR-33a as a direct post-transcriptional repressor of ABCA1 in islets, with rescue confirming the cholesterol-efflux/insulin-secretion causal link.

    Evidence Adenoviral miR-33a overexpression, anti-miRNA, cholesterol depletion, ABCA1 overexpression rescue, and insulin secretion assays

    PMID:22315319

    Open questions at the time
    • Did not define additional miR-33a islet targets contributing to phenotype
  16. 2013 Medium

    Demonstrated astrocyte-specific control of brain apoE lipidation by ABCA1 and its role in restraining neuroinflammation and supporting microglial phagocytosis.

    Evidence Cell-type-specific (brain, neuron, astrocyte) ABCA1 conditional KO mice with LPS challenge and microglial phagocytosis assays

    PMID:23376685

    Open questions at the time
    • Mechanism linking apoE loss to astrogliosis not resolved
    • Relationship to APOE genotype not addressed here
  17. 2014 Medium

    Identified HuR as a cholesterol-responsive RNA-binding protein that binds the ABCA1 3'UTR and enhances translation, adding translational control to ABCA1 regulation.

    Evidence RNA immunoprecipitation and HuR siRNA in Huh-7 and THP-1 cells with protein/mRNA and efflux assays

    PMID:24729624

    Open questions at the time
    • Single lab; mechanism of cholesterol sensing by HuR not detailed
    • In vivo relevance not tested
  18. 2015 High

    Defined an LXR-independent route to ABCA1 induction through apoptotic-cell recognition (BAI1/ELMO1/Rac1), coupling efferocytosis to efflux capacity.

    Evidence BAI1-/-, ELMO1-/-, Rac1-deficient macrophages and BAI1 transgenic mice with ABCA1 induction and high-fat diet model

    PMID:26075824

    Open questions at the time
    • Transcription factor downstream of Rac1 driving ABCA1 not identified
    • Quantitative contribution relative to LXR not established
  19. 2015 Medium

    Linked hyperglycemia to suppressed ABCA1 via loss of PRMT2-dependent LXR signaling, providing a diabetes-relevant regulatory mechanism.

    Evidence Normal/high glucose macrophages, PRMT2-/- mice, LXR reporter and efflux assays, diabetic mouse monocytes

    PMID:26288135

    Open questions at the time
    • Direct PRMT2 substrate at the ABCA1 locus not identified
    • Single lab
  20. 2015 Medium

    Identified CXCL12/CXCR4 acting through GSK3β/β-catenin/TCF21 as a transcriptional repressor of ABCA1 in macrophages.

    Evidence Reporter and ChIP assays for TCF21, phospho-blots, CXCR4 inhibition, and lentiviral CXCL12 overexpression in ApoE-/- mice

    PMID:31662443

    Open questions at the time
    • Direct TCF21 occupancy dynamics not fully resolved
    • Single lab
  21. 2015 Medium

    Showed TLR4/IRAK1 signaling downregulates ABCA1 and promotes lipid accumulation in vascular smooth muscle cells, extending ABCA1 inflammatory regulation beyond macrophages.

    Evidence IRAK1 siRNA in primary VSMCs and TLR4 KO mice on high-fat diet with oxLDL stimulation

    PMID:26512959

    Open questions at the time
    • Transcription factor downstream of IRAK1 not defined
    • Single lab
  22. 2016 Medium

    Established AMPK as an activator of ABCA1 through induction of LXRα and its promoter binding, integrating energy sensing with efflux capacity.

    Evidence AMPK activation/knockdown, LXRα/β siRNA, ChIP, reporter, and efflux assays in human macrophages

    PMID:27343431

    Open questions at the time
    • Direct AMPK substrate driving LXRα induction not identified
    • Single lab
  23. 2016 Medium

    Identified TRAK2 as a negative regulator of LXR-mediated ABCA1 expression, confirmed by ABCA1-dependent loss of the efflux phenotype.

    Evidence TRAK2 siRNA in THP-1 and HepG2, ChIP of LXR at promoter, efflux assays, ABCA1 KO cells

    PMID:28655204

    Open questions at the time
    • Mechanism by which TRAK2 limits LXR promoter occupancy unclear
    • Single lab
  24. 2017 Medium

    Identified plasminogen as a non-HDL acceptor for ABCA1-mediated cholesterol efflux, inhibited by Lp(a).

    Evidence Apolipoprotein-deficient mouse models, plasma fractionation, proteomics, and human PLG efflux assays with ABCA1-expressing cells

    PMID:28768900

    Open questions at the time
    • Physiological magnitude of PLG-dependent efflux unknown
    • Structural basis of PLG-ABCA1 interaction not defined
  25. 2017 Medium

    Defined AGE-albumin/RAGE signaling as an accelerant of ABCA1 degradation through ubiquitin-proteasome and lysosomal routes, distinct from baseline calpain-dependent turnover.

    Evidence Cycloheximide chase, proteasome/lysosome/calpain inhibitors, ubiquitination IP, and RAGE siRNA in THP-1

    PMID:29097054

    Open questions at the time
    • E3 ligase mediating ABCA1 ubiquitination not identified
    • Single lab
  26. 2019 Medium

    Showed ABCA1 physically partners with PMP22 at the Schwann cell membrane to support apoE secretion and efflux, extending ABCA1 function to peripheral nerve lipid handling.

    Evidence Reciprocal co-IP from nerve lysates, PMP22 and ABCA1 KO mice, localization, efflux, and electrophysiology

    PMID:31061090

    Open questions at the time
    • Functional consequence of PMP22-ABCA1 complex for myelination not resolved
    • Single lab
  27. 2019 Medium

    Linked APOE4 to impaired ABCA1 recycling via elevated ARF6, trapping ABCA1 in late endosomes and reducing efflux and Aβ degradation.

    Evidence ARF6 expression in APOE3/E4 astrocytes, ABCA1 localization, efflux assays, human CSF, and APOE4 targeted-replacement mice

    PMID:31641056

    Open questions at the time
    • Mechanism by which ApoE4 elevates ARF6 not defined
    • Single lab
  28. 2019 Medium

    Defined an ABCA1-driven caveolin-1/eNOS/NO pathway regulating aqueous humor outflow and intraocular pressure, an efflux-independent vascular role.

    Evidence ABCA1 shRNA, LXR agonist GW3965, transendothelial resistance, NO/eNOS quantification, and intracameral injection in vivo

    PMID:32428234

    Open questions at the time
    • Mechanism coupling ABCA1 to caveolin-1 suppression not defined
    • Single lab
  29. 2020 Medium

    Established ABCA1 as a myeloid tumor suppressor, with mutations enhancing IL-3Rβ/MAPK/JAK2 signaling and myeloproliferation that is reversed by apoA-I overexpression.

    Evidence CMML mutation sequencing, in vivo hematopoietic ABCA1 inactivation/mutant expression, signaling assays, and apoA-I transgene rescue

    PMID:32160545

    Open questions at the time
    • How ABCA1 restrains IL-3Rβ signaling biochemically not resolved
    • Single study
  30. 2022 Medium

    Reframed the transport mechanism, showing ABCA1 extracts outer-leaflet phospholipids through a gateway/annulus hydrophobic tunnel rather than acting as an inner-to-outer floppase.

    Evidence Molecular dynamics simulations with gateway/annulus mutagenesis and lipid export assays

    PMID:35974019

    Open questions at the time
    • Computational model awaits structural confirmation of the tunnel
    • Coupling to ATP hydrolysis cycle not directly demonstrated
  31. 2025 Medium

    Identified caveolin-1 as a sensor-driven mediator of ABCA1 endolysosomal trapping that activates mTORC1 and senescence in APOE4/AD models, reversible by cyclodextrin.

    Evidence Discovery proteomics, ABCA1 KO cells/mice, APOE4-TR mice, iPSC astrocytes, scRNA-seq, and cyclodextrin intervention

    PMID:39901180

    Open questions at the time
    • Direct caveolin-1-ABCA1 interaction not biochemically resolved
    • Causal chain from trapping to mTORC1 not fully dissected

Open questions

Synthesis pass · forward-looking unresolved questions
  • How ATP hydrolysis is mechanically coupled to the gateway/annulus phospholipid extraction step, and how the many transcriptional, post-translational, and trafficking regulators are integrated into net efflux in vivo, remain unresolved.
  • No experimental structure of the substrate-engaged transport cycle
  • Hierarchy among competing regulators in physiological tissue not established
  • Degradation E3 ligase(s) acting on ABCA1 not identified

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005215 transporter activity 2 GO:0008289 lipid binding 2 GO:0140104 molecular carrier activity 2 GO:0016787 hydrolase activity 1 GO:0140657 ATP-dependent activity 1
Localization
GO:0005886 plasma membrane 3 GO:0005764 lysosome 2 GO:0005768 endosome 2
Pathway
R-HSA-168256 Immune System 3 R-HSA-74160 Gene expression (Transcription) 3 R-HSA-1430728 Metabolism 2 R-HSA-382551 Transport of small molecules 2 R-HSA-5653656 Vesicle-mediated transport 2 GO:0005215 transporter activity 1
Partners
APOA1ARF6CAV1FLOT1OSBPPMP22STX13TRAK2

Evidence

Reading pass · 32 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2000 ABCA1 mediates active transport of cellular cholesterol and phospholipids to lipid-poor apolipoproteins (especially apoA-I), establishing the first step of reverse cholesterol transport and HDL particle formation. Loss-of-function mutations in ABCA1 cause Tangier disease. Genetic linkage/mutation analysis in Tangier disease patients combined with cellular cholesterol efflux assays Current opinion in lipidology High 10882340 11111099 11483617
2006 Purified human ABCA1 reconstituted in liposomes displays robust ATPase activity that is stimulated preferentially by phosphatidylcholine and sphingomyelin, inhibited by cholesterol in a structure-specific manner (beta-sitosterol and campesterol inhibit; stigmasterol does not), and suppressed by glibenclamide, providing the first direct biochemical evidence of ABCA1 enzymatic mechanism. Purification of human ABCA1 from insect Sf9 cells, reconstitution in liposomes, in vitro ATPase assay with pharmacological and lipid modulators The Journal of biological chemistry High 16500904
2007 ABCA1 activity creates two types of high-affinity apoA-I binding sites at the cell surface: a low-capacity site formed by direct apoA-I/ABCA1 interaction (regulatory role, ~10% of surface-bound apoA-I) and a much higher-capacity site formed by apoA-I interacting with ABCA1-generated lipid domains (functions in nascent HDL assembly). The C-terminal domain of apoA-I is required for lipid-domain binding but not for direct ABCA1 binding. Radiolabeled apoA-I binding assays on J774 macrophages, covalent cross-linking to ABCA1, SDS-PAGE analysis, C-terminal deletion mutants of apoA-I Arteriosclerosis, thrombosis, and vascular biology High 17478755
2008 ABCA1 and apoA-I undergo retroendocytosis via a clathrin- and Rab5-mediated pathway; approximately 30% of endocytosed ABCA1 is recycled back to the cell surface via a Rab4-mediated route. Blocking receptor-mediated endocytosis increases cell-surface ABCA1 but decreases apoA-I-mediated cholesterol efflux from cells with accumulated lipoprotein-derived cholesterol, indicating the retroendocytosis pathway contributes to HDL formation. Extracellular HA-tagged and intracellular GFP-tagged ABCA1 constructs, endocytosis/recycling assays, dominant-negative Rab GTPase constructs, cholesterol efflux assays Genes to cells : devoted to molecular & cellular mechanisms High 19170766
2005 Unsaturated fatty acids destabilize ABCA1 protein and impair lipid transport through a phospholipase D2 (PLD2)-dependent pathway: activated unsaturated acyl-CoA derivatives stimulate PLD2, which generates diacylglycerols that promote serine phosphorylation of ABCA1, leading to enhanced ABCA1 degradation. PLD inhibitor (1-butanol), PLD2 activator (mastoparan), PLD2 siRNA knockdown, acyl-CoA synthetase inhibitor (triacsin C), ABCA1 serine phosphorylation measurement, cholesterol efflux assays The Journal of biological chemistry High 16118212
2003 Retinoic acid receptors RARγ and RARα (but not RARβ) directly bind the DR4 element in the ABCA1 promoter and induce ABCA1 mRNA and protein expression in macrophages, operating through the same promoter element as LXR/RXR. In RARγ-/- macrophages, high RARα compensates for absent RARγ. Cellular cotransfection with RAR/RXR and ABCA1 promoter-reporter constructs, chromatin immunoprecipitation (ChIP), RARγ knockout mice, dose-response with ATRA and TTNPB Molecular and cellular biology High 14560020
2004 ABCA1 directly associates with syntaxin 13 (but not syntaxins 3 or 6) and flotillin-1 in lipid raft microdomains and phagosomes. Syntaxin 13 siRNA knockdown reduces ABCA1 protein levels and decreases apoA-I-dependent choline-phospholipid efflux. ABCA1 is identified as a phagosomal protein involved in vesicular lipid transport. Co-immunoprecipitation, immunofluorescence microscopy, siRNA knockdown of syntaxin 13, detergent-resistant microdomain fractionation, cholesterol/phospholipid efflux assay Molecular biology of the cell High 15469992
2007 Beta-cell-specific inactivation of Abca1 in mice causes markedly impaired glucose tolerance and defective insulin secretion (with normal insulin sensitivity), associated with altered islet cholesterol homeostasis. Rosiglitazone requires beta-cell Abca1 for its beneficial effects on glucose tolerance, establishing ABCA1 as a regulator of beta-cell cholesterol homeostasis and insulin secretion. Conditional beta-cell-specific ABCA1 knockout mice, glucose tolerance tests, insulin secretion assays in isolated islets in vitro, rosiglitazone treatment Nature medicine High 17322896
2008 OSBP (oxysterol-binding protein) negatively regulates ABCA1 protein stability by a sterol-binding domain-dependent mechanism: OSBP silencing increases ABCA1 protein half-life by 3-fold without affecting ABCA1 mRNA or LXR transcriptional activity. A sterol-binding domain mutation in OSBP abolishes its destabilizing effect on ABCA1. RNAi knockdown of OSBP in CHO cells and J774 macrophages, ABCA1 half-life measurement (cycloheximide chase), ABCA1 mRNA quantification, OSBP domain mutant transfection, cholesterol efflux assays The Journal of biological chemistry High 18450749
2007 ORP8 localizes to the endoplasmic reticulum, binds 25-hydroxycholesterol, and acts as a negative regulator of ABCA1 transcription in macrophages: ORP8 silencing by RNAi increases ABCA1 expression and cholesterol efflux to apoA-I, an effect partially mediated through the DR4 and E-box elements in the ABCA1 promoter and synergizing with LXR activation. ORP8 siRNA knockdown in THP-1 macrophages, ABCA1 promoter-luciferase reporter assay with DR4 and E-box mutations, subcellular localization by ER markers, cholesterol efflux assays The Journal of biological chemistry Medium 17991739
2009 LRP1 deficiency increases PDGFRβ/MAPK signaling, leading to phosphorylation and activation of cytosolic phospholipase A2 (cPLA2), which releases arachidonic acid that suppresses LXR/RXR activation at the ABCA1 promoter, resulting in greatly reduced ABCA1 expression and impaired cholesterol efflux. LRP1-deficient cells, MAPK pathway inhibitors, cPLA2 phosphorylation assays, LXR/RXR reporter assays, ABCA1 expression and cholesterol efflux measurements PloS one Medium 19718435
2012 miR-33a directly suppresses ABCA1 expression in pancreatic islets via binding to the 3'UTR of ABCA1 mRNA, reducing glucose-stimulated insulin secretion and increasing islet cholesterol. miR-33a-induced insulin secretion defects are rescued by cholesterol depletion or ABCA1 overexpression, confirming the causal link between ABCA1-mediated cholesterol efflux and beta-cell function. Adenoviral miR-33a overexpression in human and mouse islets, anti-miRNA treatment, cholesterol depletion (methyl-β-cyclodextrin, mevastatin), ABCA1 overexpression in beta-cell-specific ABCA1 KO islets, glucose-stimulated insulin secretion assays Diabetes High 22315319
2014 RNA-binding protein HuR directly binds the 3'UTR of ABCA1 mRNA (demonstrated by RNA immunoprecipitation) and increases ABCA1 translation. HuR silencing reduces ABCA1 protein expression and cholesterol efflux to apoA-I. Cellular cholesterol levels regulate HuR expression, localization, and its interaction with ABCA1 mRNA. RNA immunoprecipitation (RIP) assay, HuR siRNA knockdown in Huh-7 and THP-1 cells, ABCA1 protein and mRNA quantification, cholesterol efflux assays Journal of lipid research Medium 24729624
2015 Apoptotic cells trigger ABCA1 upregulation via a plasma membrane-initiated signaling pathway involving the phagocytic receptor BAI1 (recognizing phosphatidylserine), and intracellular intermediates ELMO1 and Rac1. This pathway operates independently of LXR sterol-sensing machinery; macrophages from BAI1-/- mice show attenuated ABCA1 induction. BAI1-/-, ELMO1-/-, and Rac1-deficient primary macrophages, BAI1 transgenic mice overexpressing BAI1, ABCA1 mRNA and protein induction assays, high-fat diet in vivo model The Journal of clinical investigation High 26075824
2019 ApoE4 promotes greater ARF6 expression than ApoE3, trapping ABCA1 in late endosomes and impairing its recycling to the plasma membrane. This results in lower ABCA1-mediated cholesterol efflux, greater lipid-free ApoE4 particles, and lower Aβ degradation capacity. Enhancing ABCA1 activity reduces ApoE4 aggregation and ABCA1 aggregation in hippocampus. ARF6 expression measurement in APOE3 vs APOE4 astrocytes, ABCA1 subcellular localization by fluorescence microscopy, cholesterol efflux activity assays, human CSF from APOE3/3 vs APOE4/4 carriers, ApoE4 targeted replacement mice The Journal of neuroscience Medium 31641056
2022 ABCA1 functions as an extracellular phospholipid translocase that extracts phospholipids from the outer leaflet of the plasma membrane (not as a floppase translocating from inner to outer leaflet). Simulations identified a gateway domain and annulus orifice forming a hydrophobic tunnel in the extracellular domain; engineered mutations in these domains strongly inhibit lipid export without affecting cell-surface ABCA1 expression. Molecular dynamics simulations, site-directed mutagenesis of gateway and annulus residues, ABCA1 cell-surface expression assays, lipid export functional assays Nature communications Medium 35974019
2016 TRAK2 is a negative regulator of LXR-mediated ABCA1 expression: TRAK2 siRNA knockdown increases ABCA1 mRNA and protein, enhances cholesterol efflux to apoA-I and HDL, and increases LXR binding at the ABCA1 promoter (by ChIP). The effect of TRAK2 knockdown on cholesterol efflux is abolished in ABCA1-deficient cells, confirming ABCA1 dependence. TRAK2 siRNA in THP-1 and HepG2 cells, chromatin immunoprecipitation of LXR at ABCA1 promoter, ABCA1 mRNA/protein quantification, cholesterol efflux assays, ABCA1 KO cells European heart journal Medium 28655204
2017 Plasminogen (PLG) promotes cholesterol efflux specifically through the ABCA1 pathway, and this PLG-dependent efflux is inhibited by lipoprotein(a) [Lp(a)], identifying PLG as a non-HDL acceptor for ABCA1-mediated cholesterol efflux. Genetic mouse models (APOA1-, APOE-, APOA4-deficient), size-exclusion chromatography of plasma fractions, ion-exchange chromatography, shotgun proteomics, human PLG cholesterol efflux assays with ABCA1-expressing cells JCI insight Medium 28768900
2019 PMP22 physically interacts with ABCA1 at the Schwann cell plasma membrane (co-immunoprecipitation from nerve lysates); loss of PMP22 reduces ABCA1 membrane localization, decreases apoE secretion, and impairs ABCA1-mediated cholesterol efflux, while ABCA1 KO upregulates PMP22 expression. Co-immunoprecipitation from Schwann cell and nerve lysates, PMP22 KO and ABCA1 KO mice, immunofluorescence localization, cholesterol efflux assays, electrophysiology (membrane capacitance/resistance) The Journal of neuroscience Medium 31061090
2015 High glucose inhibits LXR-dependent ABCA1 expression in macrophages through reduction of PRMT2 (protein arginine methyltransferase 2); PRMT2-/- macrophages have reduced ABCA1 expression and ABCA1-mediated cholesterol efflux, while monocytes from diabetic mice show decreased PRMT2. RAW 264.7 and BMDM cells in normal vs. high glucose, chromatin-modifying enzyme expression survey, PRMT2-/- mice, LXR reporter assays, ABCA1 expression and cholesterol efflux assays, diabetic mouse monocytes PloS one Medium 26288135
2017 AGE-albumin (advanced glycation end-products) accelerates ABCA1 degradation through both ubiquitin-proteasome and lysosomal pathways in macrophages, dependent on RAGE signaling (RAGE siRNA prevents ABCA1 reduction). Calpain inhibition does not rescue ABCA1 under AGE-albumin, unlike baseline ABCA1 degradation. Cycloheximide chase assay, proteasome inhibitor (MG-132), lysosomal inhibitor (ammonium chloride), calpain inhibitors, ABCA1 immunoprecipitation and ubiquitination assay, RAGE siRNA knockdown in THP-1 cells Journal of diabetes and its complications Medium 29097054
2016 AMPK activation increases ABCA1 and LXRα mRNA and protein in human macrophages through LXRα binding to the LXR responsive element in the ABCA1 promoter (confirmed by ChIP). LXRα silencing attenuates ABCA1 expression after AMPK activation; AMPK knockdown decreases ABCA1 and LXRα expression. Pharmacological and genetic AMPK activation/knockdown in THP-1 and primary human macrophages, LXRα/β siRNA, chromatin immunoprecipitation, luciferase reporter assay, cholesterol efflux assays The international journal of biochemistry & cell biology Medium 27343431
2015 CXCL12, acting through CXCR4, activates the GSK3β/β-catenin(T120)/TCF21 signaling pathway to suppress ABCA1 transcription in macrophages: CXCL12 phosphorylates GSK3β and β-catenin(T120), inhibiting TCF21, which normally drives ABCA1 promoter activity. CXCR4 knockdown or inhibition blocks these effects. Luciferase reporter and ChIP assays for TCF21 binding at ABCA1 promoter, GSK3β/β-catenin phosphorylation by western blot, CXCR4 inhibition/knockdown, lentiviral CXCL12 overexpression in ApoE-/- mice, cholesterol efflux assays Journal of lipid research Medium 31662443
2019 ABCA1 modulates intraocular pressure by regulating aqueous humor outflow through a caveolin-1/endothelial NOS/NO signaling pathway: ABCA1 upregulation decreases caveolin-1 and increases eNOS expression and NO production in angular aqueous plexus cells, decreasing transendothelial resistance; ABCA1 downregulation has opposite effects. Intracameral injection of LXR agonist GW3965 decreases IOP in vivo. ABCA1 shRNA lentiviral knockdown, LXR agonist GW3965 treatment, transendothelial electrical resistance measurement, eNOS/caveolin-1/NO quantification, intracameral injection in animal model, IOP and outflow facility measurement Investigative ophthalmology & visual science Medium 32428234
2020 ABCA1 mutations in CMML patients confer a proliferative advantage to myeloid cells; mechanistically, ABCA1 mutations increase IL-3Rβ signaling via MAPK and JAK2, causing metabolic reprogramming. In vivo inactivation or expression of ABCA1 mutants in hematopoietic cells (in Tet2-/- background) promotes myeloproliferation. ApoA-I transgene overexpression dampens myeloproliferation, bypassing ABCA1 defects. Somatic mutation sequencing in CMML patients, in vivo hematopoietic ABCA1 inactivation and mutant expression in mice, IL-3Rβ/MAPK/JAK2 signaling assays, apoA-I transgene rescue Cell reports Medium 32160545
2025 Caveolin-1, a sensor of cellular cholesterol accumulation, promotes ABCA1 endolysosomal trafficking and lysosomal trapping. In APOE4 and AD models, oxysterol accumulation increases caveolin-1 and ABCA1 expression, trapping ABCA1 in lysosomes, activating mTORC1, and driving cellular senescence. Cyclodextrin treatment reduces brain oxysterol levels, ABCA1 lysosomal trapping, mTORC1 activation, and senescence markers in APOE4-TR mice. Unbiased discovery proteomics to identify caveolin-1 as ABCA1 trafficking mediator, ABCA1 KO cell lines and mouse models, APOE4-TR mice, iPSC-derived astrocytes, immunofluorescence/immunoblotting, scRNA-seq, cyclodextrin intervention Molecular neurodegeneration Medium 39901180
2013 Astrocyte-specific ABCA1 controls brain apoE levels in vivo; ABCA1-deficient astrocytes show reduced apoE, whereas neuronal ABCA1 deficiency does not affect apoE levels. Brain ABCA1 deficiency causes cortical astrogliosis, increased MAPK activation, and augmented TLR4-induced inflammatory responses. Microglia lacking ABCA1 show increased TNFα secretion and decreased phagocytosis. Brain-specific, neuron-specific, and astrocyte-specific ABCA1 conditional KO mice, LPS challenge, MAPK and inflammatory cytokine assays, microglial culture phagocytosis assays, apoE protein quantification Neurobiology of disease Medium 23376685
2009 ABCA1 activity suppresses macrophage inflammation by modulating Toll-like receptor (TLR4) signaling; ABCA1 deficiency increases TLR4-mediated inflammatory cytokine and chemokine signaling, mechanistically linking cholesterol efflux to anti-inflammatory function through membrane lipid organization. ABCA1-deficient macrophages (from KO mice), TLR4 stimulation assays, inflammatory cytokine/chemokine measurement, sterol efflux assays Arteriosclerosis, thrombosis, and vascular biology Medium 19797709
2012 ApoA-I/ABCA1 interaction activates multiple downstream signaling pathways including JAK2/STAT3, PKA, Rho family GTPase CDC42, and PKC. PKA and CDC42 activation regulate ABCA1-mediated lipid efflux; PKC activation stabilizes ABCA1 protein; JAK2/STAT3 activation regulates both lipid efflux and anti-inflammatory function. Pharmacological and genetic modulation of signaling kinases in ABCA1-expressing cells, lipid efflux assays, ABCA1 protein stability assays, anti-inflammatory readouts (reviewed and validated by multiple groups) Molecular medicine (Cambridge, Mass.) Medium 22064972
2015 TLR4 signaling via IRAK1 downregulates ABCA1 expression and promotes lipid accumulation in vascular smooth muscle cells (VSMCs). IRAK1 siRNA knockdown reverses oxLDL/TLR4-induced ABCA1 downregulation. In TLR4 KO mice on a high-fat diet, IRAK1 expression and lipid accumulation are reduced with concomitant restoration of ABCA1. IRAK1 siRNA in primary cultured VSMCs, TLR4 KO mice on HFD, oxLDL stimulation, ABCA1 expression and lipid accumulation assays Cell death & disease Medium 26512959
2011 Hepatic ABCA1 is required for nascent HDL particle assembly; hepatocyte-specific ABCA1 KO (HSKO) mice show increased hepatic secretion of large TG-enriched VLDL1 particles, 50% lower LDL, and 80% reduction in HDL, with hypercatabolism of apoA-I by the kidney. Silencing ABCA1 in hepatoma cells reduces PI3K activation and increases secretion of large TG-enriched VLDL1, linking hepatic ABCA1 to VLDL metabolism. Hepatocyte-specific ABCA1 KO mice, ABCA1 siRNA in McArdle rat hepatoma cells, plasma lipoprotein profiling, VLDL secretion assays, PI3K activity measurement Biochimica et biophysica acta Medium 22001232
2016 Piperine stabilizes ABCA1 protein by inhibiting calpain-mediated ABCA1 degradation, increasing ABCA1 half-life without affecting ABCA1 mRNA levels, thereby promoting cholesterol efflux from macrophages. Cycloheximide chase assay, calpain activity inhibition assay, ABCA1 mRNA and protein quantification in THP-1 macrophages, cholesterol efflux assays Molecular nutrition & food research Low 27862930

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2009 Role of HDL, ABCA1, and ABCG1 transporters in cholesterol efflux and immune responses. Arteriosclerosis, thrombosis, and vascular biology 560 19797709
2001 ABCA1. The gatekeeper for eliminating excess tissue cholesterol. Journal of lipid research 353 11483617
2007 Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment. Nature medicine 348 17322896
2006 Role of apoA-I, ABCA1, LCAT, and SR-BI in the biogenesis of HDL. Journal of molecular medicine (Berlin, Germany) 297 16501936
2000 ABCA1-mediated transport of cellular cholesterol and phospholipids to HDL apolipoproteins. Current opinion in lipidology 236 10882340
2015 MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels. Nature medicine 213 26437365
2003 Efflux and atherosclerosis: the clinical and biochemical impact of variations in the ABCA1 gene. Arteriosclerosis, thrombosis, and vascular biology 204 12763760
2003 HDL apolipoproteins and ABCA1: partners in the removal of excess cellular cholesterol. Arteriosclerosis, thrombosis, and vascular biology 200 12615680
2000 Tangier disease and ABCA1. Biochimica et biophysica acta 185 11111099
2005 Transcriptional regulatory networks in lipid metabolism control ABCA1 expression. Biochimica et biophysica acta 172 15922656
2018 Is ABCA1 a lipid transfer protein? Journal of lipid research 142 29305383
2021 The Role of the ATP-Binding Cassette A1 (ABCA1) in Human Disease. International journal of molecular sciences 128 33562440
2019 ApoE4 Alters ABCA1 Membrane Trafficking in Astrocytes. The Journal of neuroscience : the official journal of the Society for Neuroscience 125 31641056
2012 miR-33a modulates ABCA1 expression, cholesterol accumulation, and insulin secretion in pancreatic islets. Diabetes 119 22315319
2019 Quercetin protects against atherosclerosis by regulating the expression of PCSK9, CD36, PPARγ, LXRα and ABCA1. International journal of molecular medicine 118 31524223
2014 ABCA1 and nascent HDL biogenesis. BioFactors (Oxford, England) 118 25359426
2007 ABCA1-induced cell surface binding sites for ApoA-I. Arteriosclerosis, thrombosis, and vascular biology 116 17478755
2001 Regulation and intracellular trafficking of the ABCA1 transporter. Journal of lipid research 114 11518753
2020 Brothers in Arms: ABCA1- and ABCG1-Mediated Cholesterol Efflux as Promising Targets in Cardiovascular Disease Treatment. Pharmacological reviews 111 31831519
2007 OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages. The Journal of biological chemistry 111 17991739
2022 Molecular mechanisms for ABCA1-mediated cholesterol efflux. Cell cycle (Georgetown, Tex.) 108 35192423
2003 Retinoic acid receptor-mediated induction of ABCA1 in macrophages. Molecular and cellular biology 108 14560020
2015 Apoptotic cells trigger a membrane-initiated pathway to increase ABCA1. The Journal of clinical investigation 102 26075824
2016 ABCA1 Agonist Reverses the ApoE4-Driven Cognitive and Brain Pathologies. Journal of Alzheimer's disease : JAD 96 27567858
2009 The cell cholesterol exporter ABCA1 as a protector from cardiovascular disease and diabetes. Biochimica et biophysica acta 96 19344785
2012 The interaction of ApoA-I and ABCA1 triggers signal transduction pathways to mediate efflux of cellular lipids. Molecular medicine (Cambridge, Mass.) 94 22064972
2006 Purification and ATPase activity of human ABCA1. The Journal of biological chemistry 91 16500904
2003 Study of ABCA1 function in transgenic mice. Arteriosclerosis, thrombosis, and vascular biology 91 12615681
2013 Pro-apoptotic miRNA-128-2 modulates ABCA1, ABCG1 and RXRα expression and cholesterol homeostasis. Cell death & disease 89 23990020
2005 Unsaturated fatty acids phosphorylate and destabilize ABCA1 through a phospholipase D2 pathway. The Journal of biological chemistry 87 16118212
2010 Placental ABCA1 and ABCG1 transporters efflux cholesterol and protect trophoblasts from oxysterol induced toxicity. Biochimica et biophysica acta 84 20570635
2006 Tetrahymena Genome Database (TGD): a new genomic resource for Tetrahymena thermophila research. Nucleic acids research 82 16381920
2013 ABCA1 influences neuroinflammation and neuronal death. Neurobiology of disease 81 23376685
2011 Regulation of ABCA1 functions by signaling pathways. Biochimica et biophysica acta 79 21920460
2005 ABCA1 and atherosclerosis. Vascular medicine (London, England) 78 16013195
2004 Serum amyloid A promotes ABCA1-dependent and ABCA1-independent lipid efflux from cells. Biochemical and biophysical research communications 74 15358117
2004 ABCA1 expression in carotid atherosclerotic plaques. Stroke 71 15528463
2019 MiR‑30e and miR‑92a are related to atherosclerosis by targeting ABCA1. Molecular medicine reports 70 30816508
2021 The ABCA1-efferocytosis axis: A new strategy to protect against atherosclerosis. Clinica chimica acta; international journal of clinical chemistry 65 33741356
2003 Regulation of ABCA1 expression and cholesterol efflux during adipose differentiation of 3T3-L1 cells. Journal of lipid research 64 12754274
2008 Retroendocytosis pathway of ABCA1/apoA-I contributes to HDL formation. Genes to cells : devoted to molecular & cellular mechanisms 62 19170766
2019 ABCA1 and metabolic syndrome; a review of the ABCA1 role in HDL-VLDL production, insulin-glucose homeostasis, inflammation and obesity. Diabetes & metabolic syndrome 61 31336517
2012 Quercetin enhances ABCA1 expression and cholesterol efflux through a p38-dependent pathway in macrophages. Journal of lipid research 61 22711909
2004 Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells. Molecular biology of the cell 61 15469992
2011 Function and regulation of ABCA1--membrane meso-domain organization and reorganization. The FEBS journal 55 21554545
2020 Regulation of ATP binding cassette transporter A1 (ABCA1) expression: cholesterol-dependent and - independent signaling pathways with relevance to inflammatory lung disease. Respiratory research 53 32977800
2006 ABCA1 and biogenesis of HDL. Journal of atherosclerosis and thrombosis 53 16505586
2019 CXCL12 promotes atherosclerosis by downregulating ABCA1 expression via the CXCR4/GSK3β/β-cateninT120/TCF21 pathway. Journal of lipid research 52 31662443
2006 Regulation of ABCA1 expression in human keratinocytes and murine epidermis. Journal of lipid research 52 16825673
2020 The crosstalk of ABCA1 and ANXA1: a potential mechanism for protection against atherosclerosis. Molecular medicine (Cambridge, Mass.) 51 32894039
2022 ABCA1, ABCG1, and Cholesterol Homeostasis. Advances in experimental medicine and biology 50 35575923
2013 Placental ABCA1 and ABCG1 expression in gestational disease: Pre-eclampsia affects ABCA1 levels in syncytiotrophoblasts. Placenta 49 23880356
2008 Effects of fibrate drugs on expression of ABCA1 and HDL biogenesis in hepatocytes. Journal of cardiovascular pharmacology 49 18356690
2006 ABCA1, from pathology to membrane function. Pflugers Archiv : European journal of physiology 49 16858612
2022 Role of ABCA1 in Cardiovascular Disease. Journal of personalized medicine 48 35743794
2015 Increased Systemic and Plaque Inflammation in ABCA1 Mutation Carriers With Attenuation by Statins. Arteriosclerosis, thrombosis, and vascular biology 47 26109739
2022 Remembering your A, B, C's: Alzheimer's disease and ABCA1. Acta pharmaceutica Sinica. B 46 35530134
2020 ABCA1/ApoE/HDL Signaling Pathway Facilitates Myelination and Oligodendrogenesis after Stroke. International journal of molecular sciences 45 32575457
2008 OSBP negatively regulates ABCA1 protein stability. The Journal of biological chemistry 45 18450749
2019 PMP22 Regulates Cholesterol Trafficking and ABCA1-Mediated Cholesterol Efflux. The Journal of neuroscience : the official journal of the Society for Neuroscience 43 31061090
2022 ABCA1 is an extracellular phospholipid translocase. Nature communications 42 35974019
2017 Plasminogen promotes cholesterol efflux by the ABCA1 pathway. JCI insight 42 28768900
2016 AMPK activates LXRα and ABCA1 expression in human macrophages. The international journal of biochemistry & cell biology 41 27343431
2020 ABCA1/ABCB1 Ratio Determines Chemo- and Immune-Sensitivity in Human Osteosarcoma. Cells 39 32155954
2014 RNA binding protein HuR regulates the expression of ABCA1. Journal of lipid research 39 24729624
2009 LRP1 controls cPLA2 phosphorylation, ABCA1 expression and cellular cholesterol export. PloS one 38 19718435
2016 ABCA1/ApoE/HDL Pathway Mediates GW3965-Induced Neurorestoration After Stroke. Stroke 37 28028143
2011 Hepatic ABCA1 and VLDL triglyceride production. Biochimica et biophysica acta 36 22001232
2007 Expression and biological activity of ABCA1 in alveolar epithelial cells. American journal of respiratory cell and molecular biology 36 17884990
2016 Piperine inhibits ABCA1 degradation and promotes cholesterol efflux from THP-1-derived macrophages. Molecular nutrition & food research 35 27862930
2003 Expression, regulation, and activity of ABCA1 in human cell lines. Molecular genetics and metabolism 35 12706378
2015 LXR-Mediated ABCA1 Expression and Function Are Modulated by High Glucose and PRMT2. PloS one 34 26288135
2015 IRAK1 mediates TLR4-induced ABCA1 downregulation and lipid accumulation in VSMCs. Cell death & disease 34 26512959
2012 Hesperetin upregulates ABCA1 expression and promotes cholesterol efflux from THP-1 macrophages. Journal of natural products 34 22429094
2002 ABCA1: regulation, trafficking and association with heteromeric proteins. Annals of medicine 34 12452478
2010 PPARγ activates ABCA1 gene transcription but reduces the level of ABCA1 protein in HepG2 cells. Biochemical and biophysical research communications 33 20951680
2007 ABCA1 expression in humans is associated with physical activity and alcohol consumption. Atherosclerosis 33 17481640
2023 QiShenYiQi pill inhibits atherosclerosis by promoting reverse cholesterol transport PPARγ-LXRα/β-ABCA1 pathway. Journal of ethnopharmacology 32 37230281
2020 Molecular mechanism for nobiletin to enhance ABCA1/G1 expression in mouse macrophages. Atherosclerosis 32 32062137
2025 Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD. Molecular neurodegeneration 31 39901180
2021 Recent advances in the regulation of ABCA1 and ABCG1 by lncRNAs. Clinica chimica acta; international journal of clinical chemistry 30 33545111
2017 TRAK2, a novel regulator of ABCA1 expression, cholesterol efflux and HDL biogenesis. European heart journal 30 28655204
2021 Geniposide Ameliorated Dexamethasone-Induced Cholesterol Accumulation in Osteoblasts by Mediating the GLP-1R/ABCA1 Axis. Cells 29 34943934
2019 Impact of natural products on the cholesterol transporter ABCA1. Journal of ethnopharmacology 29 31805338
2022 Cholesterol homeostasis regulated by ABCA1 is critical for retinal ganglion cell survival. Science China. Life sciences 28 35829808
2022 HDL, cholesterol efflux, and ABCA1: Free from good and evil dualism. Journal of pharmacological sciences 28 36055755
2009 HIF-1beta determines ABCA1 expression under hypoxia in human macrophages. The international journal of biochemistry & cell biology 28 19828131
2022 Roles of ABCA1 in cancer. Oncology letters 26 36072007
2020 ABCA1 Regulates IOP by Modulating Cav1/eNOS/NO Signaling Pathway. Investigative ophthalmology & visual science 25 32428234
2017 AGE-albumin enhances ABCA1 degradation by ubiquitin-proteasome and lysosomal pathways in macrophages. Journal of diabetes and its complications 25 29097054
2022 Astrocytic dysfunction induced by ABCA1 deficiency causes optic neuropathy. Science advances 24 36332025
2019 p62/mTOR/LXRα pathway inhibits cholesterol efflux mediated by ABCA1 and ABCG1 during autophagy blockage. Biochemical and biophysical research communications 24 31101336
2015 Silymarin Constituents Enhance ABCA1 Expression in THP-1 Macrophages. Molecules (Basel, Switzerland) 24 26729088
2021 Genomic Variants and Multilevel Regulation of ABCA1, ABCG1, and SCARB1 Expression in Atherogenesis. Journal of cardiovascular development and disease 23 34940525
2019 LXRβ controls glioblastoma cell growth, lipid balance, and immune modulation independently of ABCA1. Scientific reports 23 31664073
2016 ABCA1 agonist peptides for the treatment of disease. Current opinion in lipidology 23 26655293
2011 ABCA1, ABCG1, and SR-BI: Transit of HDL-associated sphingosine-1-phosphate. Clinica chimica acta; international journal of clinical chemistry 23 22115863
2020 ABCA1 Exerts Tumor-Suppressor Function in Myeloproliferative Neoplasms. Cell reports 22 32160545
2008 Effect of ABCA1 mutations on risk for myocardial infarction. Current atherosclerosis reports 22 18706283
2006 Molecular defects in the ABCA1 pathway affect platelet function. Pathophysiology of haemostasis and thrombosis 22 16855366

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