Affinage

ZNF804A

Zinc finger protein 804A · UniProt Q7Z570

Length
1209 aa
Mass
136.9 kDa
Annotated
2026-04-28
100 papers in source corpus 18 papers cited in narrative 19 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ZNF804A is a zinc-finger protein that functions as a dual-mode regulator of gene expression in neurons, acting both as a transcriptional regulator that directly binds chromatin at promoters of schizophrenia-associated genes (PRSS16, COMT) to modulate their transcription (PMID:22384243, PMID:32626976) and as an RNA-binding component of the translational machinery that co-fractionates with ribosomes, associates with short mRNA transcripts, and modulates mTOR-dependent translation (PMID:28924186). ZNF804A localizes to both nuclear and somatodendritic/synaptic compartments in neurons, where it regulates neurite outgrowth, dendritic spine density, and activity-dependent structural plasticity in a dosage-sensitive manner, with binding partners RPSA, LGALS1, and FEZ1 differentially rescuing loss- and gain-of-function phenotypes (PMID:27837918, PMID:33446247). ZNF804A also participates in interferon signaling by interacting with STAT2 and co-translocating to the nucleus upon IFN stimulation to regulate ISRE-dependent gene expression (PMID:34364876, PMID:25905630).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 2010 Medium

    Establishing upstream transcriptional control of ZNF804A: Hoxc8 was shown to bind an intronic region of Zfp804a and upregulate its transcription, providing the first evidence that ZNF804A expression is under developmental transcriptional regulation.

    Evidence ChIP-PCR and luciferase reporter in mouse F9 cells and embryos

    PMID:20508826

    Open questions at the time
    • Whether Hoxc8 regulation of ZNF804A is relevant in postnatal or adult brain
    • No human validation of this regulatory axis
  2. 2011 Medium

    ZNF804A knockdown revealed its role in regulating genes involved in cell adhesion and neurite outgrowth, establishing it as a regulator of neurodevelopmental gene programs.

    Evidence siRNA knockdown in human cortical neural progenitor cells with transcriptome analysis

    PMID:22080834

    Open questions at the time
    • Direct transcriptional targets versus indirect effects were not distinguished
    • No protein-level validation of downstream targets
  3. 2012 High

    ZNF804A was established as a bona fide transcription factor by demonstrating direct chromatin binding at PRSS16 and COMT promoters and transcriptional regulation of multiple schizophrenia-associated genes (PRSS16, COMT, PDE4B, DRD2).

    Evidence ChIP with epitope-tagged and endogenous ZNF804A, qRT-PCR in rat neural progenitor cells

    PMID:22384243

    Open questions at the time
    • Genome-wide binding profile not determined
    • Whether zinc-finger domain mediates DNA binding was not tested
  4. 2012 Medium

    MiR-137 was identified as a post-transcriptional suppressor of ZNF804A, linking two independent schizophrenia GWAS loci into a single regulatory pathway.

    Evidence Luciferase reporter assay with ZNF804A 3'UTR

    PMID:22883350

    Open questions at the time
    • Endogenous miR-137 regulation of ZNF804A protein levels in neurons not demonstrated
    • Functional consequences of miR-137-mediated ZNF804A suppression not tested
  5. 2014 High

    ZNF804A protein expression was mapped across the human lifespan, revealing peak prenatal expression in pyramidal neurons and identification of a truncated isoform (ZNF804AE3E4) lacking the zinc-finger domain whose expression is regulated by the schizophrenia risk SNP rs1344706 specifically in fetal brain.

    Evidence Western blot, IHC, NGS, and genotype-stratified eQTL analysis across 697 brain samples

    PMID:25162540

    Open questions at the time
    • Function of the truncated isoform unknown
    • Whether the truncated isoform acts as a dominant-negative is untested
  6. 2015 Medium

    Multiple regulatory inputs to ZNF804A expression were defined: glutamate/NMDAR signaling induces Zfp804a expression, HSF2 suppresses ZNF804A transcription in an allele-specific manner at rs10497655, and Sp1 binding at rs359895 modulates promoter activity, establishing ZNF804A as an activity-regulated gene under complex promoter control.

    Evidence Pharmacological NMDAR blockade in rat cortical neurons; EMSA and ChIP for HSF2 and Sp1 at promoter SNPs; luciferase reporters

    PMID:21890790 PMID:26164821 PMID:30670685

    Open questions at the time
    • Whether NMDAR-dependent regulation occurs in human neurons
    • Interaction between activity-dependent and allele-specific regulatory mechanisms not tested
  7. 2015 Medium

    ZNF804A knockdown in iPSC-derived neurons revealed enrichment of interferon-signaling genes among downregulated transcripts, and dynamic localization of Zfp804a from perinuclear regions to growth cones during neurite extension was established.

    Evidence shRNA KD with RNA-seq in iPSC-derived neurons; immunocytochemistry in rat cortical neurons across developmental time points

    PMID:25905630 PMID:26148198

    Open questions at the time
    • Interferon pathway link was correlational at this stage
    • Growth cone localization not linked to specific molecular function
  8. 2016 High

    ZNF804A was placed at synapses using super-resolution microscopy and shown to be required for dendritic spine density and activity-dependent structural plasticity, establishing a synaptic structural role beyond transcription.

    Evidence Super-resolution microscopy, siRNA KD in human NPC/iPSC-derived and rat cortical neurons with spine morphometry

    PMID:27837918

    Open questions at the time
    • Molecular mechanism of ZNF804A action at synapses unresolved
    • Whether synaptic and nuclear functions are mediated by the same or different isoforms
  9. 2017 High

    ZNF804A was unexpectedly shown to co-fractionate with translational machinery, bind mRNA targets including NRGN via RIP-Seq, and modulate mTOR-dependent translation, revealing a second major molecular function beyond transcription. RPSA was identified as a key interacting partner that rescues migration and translational defects.

    Evidence Yeast two-hybrid screen, co-fractionation, RIP-Seq, Duolink assay, in vivo mouse KD with rescue

    PMID:28924186

    Open questions at the time
    • Whether ZNF804A binds RNA directly or through ribosomes
    • Structural basis for dual DNA/RNA engagement unknown
    • Full spectrum of mRNA targets in human neurons not defined
  10. 2020 Medium

    miR-148b-3p was validated as a second microRNA targeting ZNF804A, and shown to propagate effects to downstream ZNF804A transcriptional targets COMT and PRSS16, confirming the miRNA–ZNF804A–target gene regulatory axis.

    Evidence Luciferase 3'UTR reporter, qRT-PCR and Western blot in SH-SY5Y cells

    PMID:32626976

    Open questions at the time
    • Endogenous levels and relevance of miR-148b-3p in developing brain not established
  11. 2021 High

    ZNF804A was shown to interact with STAT2 via its unstructured N-terminus and co-translocate to the nucleus upon IFN stimulation, modulating ISRE-dependent transcription, thus mechanistically linking ZNF804A to innate immune signaling.

    Evidence Yeast two-hybrid, bioluminescence PPI assays, domain mutagenesis, immunofluorescence co-translocation, ISRE luciferase reporter in HEK293 cells

    PMID:34364876

    Open questions at the time
    • Whether ZNF804A–STAT2 interaction occurs in neurons
    • Genome-wide effect on IFN-responsive genes not mapped
    • Whether this interaction is relevant to schizophrenia pathophysiology
  12. 2021 Medium

    Dosage sensitivity of ZNF804A was formally demonstrated: both knockdown and overexpression impair dendritic morphology, and differential rescue by LGALS1, FEZ1, and RPSA indicates that ZNF804A functions through multiple effector pathways for neurite outgrowth versus dendritic arborization.

    Evidence Bidirectional shRNA KD and overexpression in primary neurons with binding-partner rescue experiments

    PMID:33446247

    Open questions at the time
    • Biochemical basis for differential rescue by different partners unknown
    • Whether dosage sensitivity underlies psychiatric risk allele effects
  13. 2024 Medium

    ZNF804A forms a complex with NT5C2, another schizophrenia risk gene product, in cortical neurons, with each protein influencing the subcellular targeting of the other, suggesting coordinated function of two independently identified risk loci.

    Evidence Co-IP in HEK293T and rat cortical neurons, siRNA KD with subcellular redistribution analysis

    PMID:38279611

    Open questions at the time
    • Functional consequence of ZNF804A–NT5C2 complex formation unknown
    • Whether this complex acts in translation, transcription, or a distinct pathway is unresolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • Major open questions include: the structural basis for ZNF804A's dual DNA- and RNA-binding activities; whether nuclear transcriptional and cytoplasmic translational functions are mediated by distinct isoforms or regulated by dynamic shuttling; the genome-wide DNA and RNA binding landscapes in human neurons; and how ZNF804A genetic variants mechanistically increase schizophrenia risk through these pathways.
  • No crystal or cryo-EM structure available
  • Isoform-specific functions not dissected
  • Genome-wide ChIP-seq and CLIP-seq in human neurons not performed

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 3 GO:0003677 DNA binding 1 GO:0003723 RNA binding 1 GO:0045182 translation regulator activity 1
Localization
GO:0005634 nucleus 3 GO:0005829 cytosol 3 GO:0005840 ribosome 1
Pathway
R-HSA-1266738 Developmental Biology 3 R-HSA-74160 Gene expression (Transcription) 3 R-HSA-162582 Signal Transduction 2 R-HSA-168256 Immune System 2 R-HSA-392499 Metabolism of proteins 1
Partners
FEZ1LGALS1NRGNNT5C2RPSASTAT2

Evidence

Reading pass · 19 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2012 ZNF804A functions as a transcriptional regulator: it directly binds chromatin proximal to the promoter regions of PRSS16 and COMT (confirmed by ChIP with both epitope-tagged and endogenous ZNF804A), upregulates PRSS16 and COMT transcript levels, and downregulates PDE4B and DRD2 transcript levels in rat neural progenitor cells. ZNF804A was localized to the nucleus of these cells in culture and in vivo. Chromatin immunoprecipitation (ChIP), qRT-PCR gene expression assays, immunochemistry for subcellular localization PloS one High 22384243
2011 Knockdown of ZNF804A in human cortical neural progenitor cells significantly alters expression of genes involved in cell adhesion, with the most consistent changes in C2ORF80 and STMN3 (involved in neurite outgrowth and axonal/dendritic branching), suggesting a role for ZNF804A in neural migration, neurite outgrowth, and synapse formation. siRNA-mediated knockdown in human cortical neuroepithelium-derived neural progenitor cells followed by transcriptome analysis and gene ontology analysis; validated in repeat cell culture experiments Human molecular genetics Medium 22080834
2016 ZNF804A protein localizes to somatodendritic compartments and colocalizes with synaptic markers in young neurons (human NPCs and iPSC-derived neurons). In mature rat neurons, the homolog Zfp804A is present in a subset of dendritic spines and colocalizes with synaptic proteins in nanodomains (super-resolution microscopy). Knockdown of ZNF804A attenuates neurite outgrowth (potentially mediated by reduced neuroligin-4 expression), reduces dendritic spine density, and impairs activity-dependent structural plasticity in mature neurons. Immunocytochemistry, super-resolution microscopy, siRNA knockdown in human NPC- and iPSC-derived neurons and rat cortical neurons, morphological analysis of neurite outgrowth and dendritic spine density Biological psychiatry High 27837918
2017 ZNF804A interacts with multiple proteins involved in mRNA translation (identified by yeast two-hybrid genome-wide screen), co-fractionates with translational machinery, and modulates translational efficiency as well as the mTOR pathway. The ribosomal protein RPSA interacts with ZNF804A and rescues migration and translational defects caused by ZNF804A knockdown. ZFP804A (mouse homolog) associates with short transcripts involved in translational and mitochondrial regulation (RIP-Seq), including the schizophrenia risk gene NRGN; downregulation of ZFP804A decreases NRGN expression and overexpression of NRGN ameliorates ZFP804A-mediated migration defects. ZNF804A knockdown in mouse impairs progenitor proliferation and neuronal migration. Yeast two-hybrid genome-wide screen, co-fractionation with translational machinery, RNA immunoprecipitation-sequencing (RIP-Seq), Duolink in situ interaction assay, in vivo mouse knockdown with migration/proliferation assays Molecular psychiatry High 28924186
2021 ZNF804A interacts with STAT2 (signal transducer and activator of transcription 2): STAT2 binds to the unstructured N-terminus of ZNF804A via multiple short amino acid motifs (but not the C2H2 zinc-finger domain). Upon interferon (IFN) treatment, ZNF804A and STAT2 co-translocate from the cytoplasm into the nucleus. ZNF804A overproduction has a concentration-dependent effect on STAT2-mediated gene expression via an IFN-stimulated response element (ISRE) luciferase reporter. Yeast two-hybrid, bioluminescence-based PPI detection assays, domain-mapping mutagenesis, immunofluorescence for co-translocation, ISRE luciferase reporter assay in HEK293 cells Journal of molecular biology High 34364876
2021 Both knockdown and overexpression of ZNF804A in primary neurons significantly attenuate dendritic complexity and spine formation, demonstrating dosage sensitivity. Three ZNF804A binding partners—LGALS1, FEZ1, and RPSA—have differential rescue effects: LGALS1 reverses neurite outgrowth deficits caused by ZNF804A knockdown, while FEZ1 and RPSA (but not LGALS1) ameliorate dendritic abnormalities caused by ZNF804A overexpression. shRNA knockdown and overexpression in primary neuronal cells, morphological analysis of dendritic complexity and spine density, rescue experiments with binding partner overexpression Molecular brain Medium 33446247
2024 ZNF804A/ZFP804A and NT5C2 colocalize and form a protein complex in cortical neurons (confirmed in HEK293T cells and rat cortical neurons). Knockdown of Zfp804a or Nt5c2 results in redistribution of both proteins, indicating that each protein influences the subcellular targeting of the other. Co-immunoprecipitation in HEK293T cells, co-localization and co-IP in rat cortical neurons, siRNA knockdown with subcellular redistribution readout The European journal of neuroscience Medium 38279611
2012 ZNF804A is validated as a direct target of hsa-miR-137: luciferase-based assays confirmed that hsa-miR-137 binds the ZNF804A 3'UTR to suppress its expression. In silico target prediction, cellular assays, luciferase reporter assay with ZNF804A 3'UTR Schizophrenia research Medium 22883350
2020 miR-148b-3p directly targets ZNF804A via conserved binding sites in the 3'UTR of ZNF804A mRNA, inhibiting ZNF804A expression at both mRNA and protein levels in SH-SY5Y cells. miR-148b-3p further regulates downstream ZNF804A targets COMT and PRSS16 through this mechanism. Luciferase reporter assay with ZNF804A 3'UTR, qRT-PCR and Western blot for ZNF804A expression after miR-148b-3p manipulation, expression assays for COMT and PRSS16 Molecular medicine reports Medium 32626976
2010 The mouse ZNF804A homolog Zfp804a is a downstream transcriptional target of Hoxc8: Hoxc8 binds an intronic region of Zfp804a (confirmed by ChIP-PCR in F9 cells and mouse embryos), upregulates Zfp804a mRNA levels, and augments minimal promoter activity in vitro. Zfp804a and Hoxc8 are coexpressed in E11.5 mouse embryos. ChIP-cloning, ChIP-PCR, luciferase reporter (minimal promoter activity), in situ expression analysis in mouse embryos Journal of biomedicine & biotechnology Medium 20508826
2015 ZNF804A knockdown in iPSC-derived differentiating neurons affects interferon signaling: genes involved in interferon-alpha 2 (IFNA2)-mediated gene expression are enriched among downregulated genes, and ZNF804A KD was found to affect IFNA2-mediated gene expression. shRNA lentiviral knockdown in iPSC-derived neural progenitor cells, neuronal differentiation, RNA-seq transcriptome analysis, pathway enrichment analysis PloS one Medium 25905630
2015 ZNF804A knockdown in SH-SY5Y cells reduces SNAP25 expression, and ZNF804A and SNAP25 expression are strongly positively correlated in human anterior cingulate gyrus postmortem brain tissue, suggesting ZNF804A regulates SNAP25 transcription. In vitro ZNF804A silencing with expression assays for SNAP25; postmortem brain qRT-PCR correlation analysis Journal of psychiatry & neuroscience : JPN Low 24866414
2015 The rat ZNF804A homolog Zfp804A protein is localized to growth cones of growing neurites in cultured cortical neurons (at day 4 of culture), shifting from perinuclear localization at earlier time points, implicating ZFP804A in growth cone function and neurite elongation. Immunocytochemistry in rat cultured cortical neurons across developmental time points; in situ hybridization for mRNA expression across postnatal brain development PloS one Medium 26148198
2015 Zfp804a (rat homolog) mRNA expression in cortical neurons is significantly increased upon glutamate exposure [20 µM], and this increase is blocked by the NMDA receptor antagonist MK-801, demonstrating glutamate/NMDAR-dependent regulation of ZNF804A expression. Expression of ZNF804A-regulated genes Comt, Pde4b, and Drd2 also changed in an NMDA-dependent manner. Primary rat cortical neuron culture with pharmacological glutamate and MK-801 treatment, qRT-PCR for Zfp804a and downstream targets Schizophrenia research Medium 26164821
2014 The ZNF804A risk SNP rs359895, located in the ZNF804A promoter, influences Sp1 transcription factor binding affinity and results in higher promoter activity of the risk allele, as demonstrated by functional assays in a Han Chinese population study. Electrophoretic mobility shift assay (EMSA) for transcription factor binding, luciferase promoter activity assay The American journal of psychiatry Medium 21890790
2019 The ZNF804A promoter SNP rs10497655 (T risk allele) is associated with reduced ZNF804A expression in human fetal brains. HSF2 (heat shock factor 2) acts as a transcriptional suppressor that binds the rs10497655 region and has stronger binding affinity for the T allele than the C allele, downregulating ZNF804A expression. EMSA for HSF2 binding affinity, chromatin immunoprecipitation (ChIP) for HSF2 at the ZNF804A promoter, dual-luciferase assay for promoter activity, qRT-PCR for expression in fetal brain Translational psychiatry Medium 30670685
2014 ZNF804A protein is expressed in human cerebral cortex neurons across the lifespan, with highest expression prenatally. It is localized primarily to pyramidal neurons with cytoplasmic, dendritic, and nuclear staining. A truncated isoform (ZNF804AE3E4), missing exons 1 and 2 and lacking the zinc finger domain, is abundant and developmentally regulated; expression of this isoform is influenced by the rs1344706 risk SNP specifically in fetal brain. Western blot, immunohistochemistry, next-generation sequencing and PCR for transcript isoforms, quantitative mRNA analysis across 697 brain samples (14 gestational weeks to age 85), genotype-stratified eQTL analysis JAMA psychiatry High 25162540
2021 ZNF804A is expressed in various types of neurons in mouse brain including pyramidal, dopaminergic, GABAergic, and Purkinje neurons, and localizes to the cytoplasm and neurites in human cortex. Immunofluorescence in mouse brain sections and human cortex tissue Molecular brain Low 33446247
2021 ZNF804A rs1344706 genotype is associated with D2/D3 dopamine receptor availability in the associative and sensorimotor striatum in healthy humans: risk-allele homozygotes (AA) show significantly less D2/D3 receptor availability compared to non-risk allele carriers, consistent with the known upregulation of DRD2 transcription by ZNF804A. In vivo [18F]fallypride and [11C]NNC-112 PET scanning for D2/D3 and D1 receptor availability in 72 genotyped healthy individuals; region-of-interest and voxelwise analyses Biological psychiatry. Cognitive neuroscience and neuroimaging Medium 33712377

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2010 Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder. Molecular psychiatry 223 20368704
2009 Replication of association between schizophrenia and ZNF804A in the Irish Case-Control Study of Schizophrenia sample. Molecular psychiatry 178 19844207
2011 Altered cortical network dynamics: a potential intermediate phenotype for schizophrenia and association with ZNF804A. Archives of general psychiatry 147 21810628
2010 Psychosis susceptibility gene ZNF804A and cognitive performance in schizophrenia. Archives of general psychiatry 113 20603450
2014 Expression of ZNF804A in human brain and alterations in schizophrenia, bipolar disorder, and major depressive disorder: a novel transcript fetally regulated by the psychosis risk variant rs1344706. JAMA psychiatry 91 25162540
2012 ZNF804a regulates expression of the schizophrenia-associated genes PRSS16, COMT, PDE4B, and DRD2. PloS one 85 22384243
2011 Knockdown of the psychosis susceptibility gene ZNF804A alters expression of genes involved in cell adhesion. Human molecular genetics 83 22080834
2012 Experimental validation of candidate schizophrenia gene ZNF804A as target for hsa-miR-137. Schizophrenia research 79 22883350
2010 A schizophrenia risk gene, ZNF804A, influences neuroanatomical and neurocognitive phenotypes. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 74 20664580
2016 Psychosis Risk Candidate ZNF804A Localizes to Synapses and Regulates Neurite Formation and Dendritic Spine Structure. Biological psychiatry 70 27837918
2012 Evidence that schizophrenia risk variation in the ZNF804A gene exerts its effects during fetal brain development. The American journal of psychiatry 66 23212061
2011 Allelic differences between Han Chinese and Europeans for functional variants in ZNF804A and their association with schizophrenia. The American journal of psychiatry 65 21890790
2010 The impact of a genome-wide supported psychosis variant in the ZNF804A gene on memory function in schizophrenia. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 55 20957649
2011 The ZNF804A gene: characterization of a novel neural risk mechanism for the major psychoses. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 49 21525856
2011 Evidence of sex-modulated association of ZNF804A with schizophrenia. Biological psychiatry 48 21349497
2017 The schizophrenia risk gene ZNF804A: clinical associations, biological mechanisms and neuronal functions. Molecular psychiatry 47 28289284
2010 The psychosis susceptibility gene ZNF804A: associations, functions, and phenotypes. Schizophrenia bulletin 47 20688871
2012 Influence of ZNF804a on brain structure volumes and symptom severity in individuals with schizophrenia. Archives of general psychiatry 38 22945618
2011 ANK3, CACNA1C and ZNF804A gene variants in bipolar disorders and psychosis subphenotype. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 36 21767209
2017 Interactome analysis reveals ZNF804A, a schizophrenia risk gene, as a novel component of protein translational machinery critical for embryonic neurodevelopment. Molecular psychiatry 35 28924186
2010 ZNF804A may be associated with executive control of attention. Genes, brain, and behavior 35 21040459
2012 Evidence of IQ-modulated association between ZNF804A gene polymorphism and cognitive function in schizophrenia patients. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 34 22373944
2015 ZNF804A Transcriptional Networks in Differentiating Neurons Derived from Induced Pluripotent Stem Cells of Human Origin. PloS one 31 25905630
2012 ZNF804A and schizophrenia susceptibility in Asian populations. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 30 22887939
2012 Genome-wide supported psychosis risk variant in ZNF804A gene and impact on cortico-limbic WM integrity in schizophrenia. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 29 22328493
2014 Variability in working memory performance explained by epistasis vs polygenic scores in the ZNF804A pathway. JAMA psychiatry 28 24828433
2013 ZNF804A and cortical structure in schizophrenia: in vivo and postmortem studies. Schizophrenia bulletin 28 24078172
2011 Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene. Neuroscience letters 28 21457757
2011 The schizophrenia risk gene ZNF804A influences the antipsychotic response of positive schizophrenia symptoms. European archives of psychiatry and clinical neuroscience 28 21892778
2013 Association of rs1344706 in the ZNF804A gene with schizophrenia in a case/control sample from Indonesia. Schizophrenia research 27 23590871
2013 Evidence of allelic imbalance in the schizophrenia susceptibility gene ZNF804A in human dorsolateral prefrontal cortex. Schizophrenia research 27 24315717
2011 Association of the ZNF804A gene polymorphism rs1344706 with white matter density changes in Chinese schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry 26 21911029
2016 The impact of CACNA1C gene, and its epistasis with ZNF804A, on white matter microstructure in health, schizophrenia and bipolar disorder1. Genes, brain, and behavior 25 27790829
2012 Further evidence for the association of genetic variants of ZNF804A with schizophrenia and a meta-analysis for genome-wide significance variant rs1344706. Schizophrenia research 25 22871346
2015 ZNF804A Genetic Variation Confers Risk to Bipolar Disorder. Molecular neurobiology 24 25935703
2014 Zinc finger protein 804A (ZNF804A) and verbal deficits in individuals with autism. Journal of psychiatry & neuroscience : JPN 23 24866414
2012 An investigation of a genomewide supported psychosis variant in ZNF804A and white matter integrity in the human brain. Magnetic resonance imaging 23 22840435
2016 Genome-wide discovered psychosis-risk gene ZNF804A impacts on white matter microstructure in health, schizophrenia and bipolar disorder. PeerJ 22 26966642
2015 Bioinformatic analyses and conceptual synthesis of evidence linking ZNF804A to risk for schizophrenia and bipolar disorder. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 21 25522715
2015 ZNF804A rs1344706 is associated with cortical thickness, surface area, and cortical volume of the unmedicated first episode schizophrenia and healthy controls. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 21 25921517
2012 Variation in psychosis gene ZNF804A is associated with a refined schizotypy phenotype but not neurocognitive performance in a large young male population. Schizophrenia bulletin 21 23155182
2014 A schizophrenia risk gene, ZNF804A, is associated with brain white matter microstructure. Schizophrenia research 19 24685285
2014 No effect of schizophrenia risk genes MIR137, TCF4, and ZNF804A on macroscopic brain structure. Schizophrenia research 19 25217366
2010 Mouse Homologue of the Schizophrenia Susceptibility Gene ZNF804A as a Target of Hoxc8. Journal of biomedicine & biotechnology 19 20508826
2010 No evidence that rare coding variants in ZNF804A confer risk of schizophrenia. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 18 20862696
2021 Schizophrenia risk ZNF804A interacts with its associated proteins to modulate dendritic morphology and synaptic development. Molecular brain 17 33446247
2020 Schizophrenia‑associated microRNA‑148b‑3p regulates COMT and PRSS16 expression by targeting the ZNF804A gene in human neuroblastoma cells. Molecular medicine reports 17 32626976
2014 ZNF804A genetic variation (rs1344706) affects brain grey but not white matter in schizophrenia and healthy subjects. Psychological medicine 17 25065377
2013 ZNF804A genotype modulates neural activity during working memory for faces. Neuropsychobiology 17 23295962
2014 Effects of ZNF804A on auditory P300 response in schizophrenia. Translational psychiatry 16 24424391
2015 Effect of rs1344706 in the ZNF804A gene on the connectivity between the hippocampal formation and posterior cingulate cortex. Schizophrenia research 15 26654932
2012 Association analysis of ZNF804A (zinc finger protein 804A) rs1344706 with therapeutic response to atypical antipsychotics in first-episode Chinese patients with schizophrenia. Comprehensive psychiatry 15 22425527
2018 The effect of psychosis associated CACNA1C, and its epistasis with ZNF804A, on brain function. Genes, brain, and behavior 14 30079586
2013 Evaluation of the relationship between the ZNF804A single nucleotide polymorphism rs1344706 A/C variant and schizophrenia subtype in Han Chinese patients. International journal of psychiatry in medicine 14 24066410
2012 Evidence for the involvement of ZNF804A in cognitive processes of relevance to reading and spelling. Translational psychiatry 14 22781169
2012 Less cognitive and neurological deficits in schizophrenia patients carrying risk variant in ZNF804A. Neuropsychobiology 14 22948380
2011 Is the conserved mammalian region of ZNF804A locus associated with schizophrenia? A population-based genetics analysis. Schizophrenia research 14 21993378
2017 Effect of rs1344706 in the ZNF804A gene on the brain network. NeuroImage. Clinical 13 29527501
2015 Postnatal neurodevelopmental expression and glutamate-dependent regulation of the ZNF804A rodent homologue. Schizophrenia research 13 26164821
2016 The schizophrenia susceptibility gene ZNF804A confers risk of major mood disorders. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 12 27784192
2015 Associations between the schizophrenia susceptibility gene ZNF804A and clinical outcomes in psychosis. Translational psychiatry 12 26670283
2016 No association between ZNF804A rs1344706 and schizophrenia in a case-control study of Han Chinese. Neuroscience letters 11 26934312
2017 Genetic association of rs1344706 in ZNF804A with bipolar disorder and schizophrenia susceptibility in Chinese populations. Scientific reports 10 28120939
2017 The genome-wide associated candidate gene ZNF804A and psychosis-proneness: Evidence of sex-modulated association. PloS one 10 28931092
2015 The Rat Homolog of the Schizophrenia Susceptibility Gene ZNF804A Is Highly Expressed during Brain Development, Particularly in Growth Cones. PloS one 10 26148198
2019 A promoter variant in ZNF804A decreasing its expression increases the risk of autism spectrum disorder in the Han Chinese population. Translational psychiatry 9 30670685
2014 Association between rs1344706 of ZNF804A and schizophrenia: a meta-analysis. Genomics, proteomics & bioinformatics 9 25526981
2020 The expression of zinc finger 804a (ZNF804a) and cyclin-dependent kinase 1 (CDK1) genes is related to the pathogenesis of rheumatoid arthritis. Archives of physiology and biochemistry 8 31994908
2020 Effect of ZNF804A gene polymorphism (rs1344706) on the plasticity of the functional coupling between the right dorsolateral prefrontal cortex and the contralateral hippocampal formation. NeuroImage. Clinical 8 32544854
2018 Genetic analysis of common variants in the ZNF804A gene with schizophrenia and major depressive disorder. Psychiatric genetics 8 29112096
2018 The interaction between the ZNF804A gene and cannabis use on the risk of psychosis in a non-clinical sample. Progress in neuro-psychopharmacology & biological psychiatry 8 30118824
2017 Association between the zinc finger protein 804A (ZNF804A) gene and the risk of schizophrenia and bipolar I disorder across diagnostic boundaries. Bipolar disorders 8 28544350
2017 The impact of psychosis genome-wide associated ZNF804A variation on verbal fluency connectivity. Journal of psychiatric research 8 29257977
2015 Elevated P3b latency variability in carriers of ZNF804A risk allele for psychosis. NeuroImage 8 25896933
2018 ZNF804A rs1344706 interacts with COMT rs4680 to affect prefrontal volume in healthy adults. Brain imaging and behavior 7 28078547
2021 Schizophrenia risk candidate protein ZNF804A interacts with STAT2 and influences interferon-mediated gene transcription in mammalian cells. Journal of molecular biology 6 34364876
2014 Lack of association of the rs1344706 ZNF804A variant with cognitive functions and DTI indices of white matter microstructure in two independent healthy populations. Psychiatry research 6 24636489
2013 Investigation of the ZNF804A gene polymorphism with genetic risk for bipolar disorder in attention deficit hyperactivity disorder. BMC research notes 6 23351715
2011 A polymerase chain reaction-restriction fragment length polymorphism method for screening ZNF804A gene polymorphism (rs1344706) in patients with schizophrenia: a significant association. Genetic testing and molecular biomarkers 6 21988329
2022 The Interaction Between Genetic Variant ZNF804A rs1344706 and Alcohol Withdrawal on Impulsivity: Evidence for the Diathesis-Stress Model. Frontiers in psychiatry 5 35046850
2020 ZNF804A Gene Variants Have a Cross-diagnostic Influence on Psychosis and Treatment Improvement in Mood Disorders. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology 5 32329304
2019 Spontaneous Regional Brain Activity in Healthy Individuals is Nonlinearly Modulated by the Interaction of ZNF804A rs1344706 and COMT rs4680 Polymorphisms. Neuroscience bulletin 5 30852803
2019 Pleiotropic action of genetic variation in ZNF804A on brain structure: a meta-analysis of magnetic resonance imaging studies. Neuropsychiatric disease and treatment 5 30962687
2017 Molecular genetic characterization of a prenatally detected de novo interstitial deletion of chromosome 2q (2q31.1-q32.1) encompassing HOXD13, ZNF385B and ZNF804A associated with syndactyly and increased first-trimester nuchal translucency. Taiwanese journal of obstetrics & gynecology 5 28600059
2015 Replication of ZNF804A gene variant associations with risk of heroin addiction. Genes, brain, and behavior 5 26382569
2017 Common variation in ZNF804A (rs1344706) is not associated with brain morphometry in schizophrenia or healthy participants. Progress in neuro-psychopharmacology & biological psychiatry 4 29247760
2024 Schizophrenia risk proteins ZNF804A and NT5C2 interact in cortical neurons. The European journal of neuroscience 3 38279611
2022 A functional neuroimaging association study on the interplay between two schizophrenia genome-wide associated genes (CACNA1C and ZNF804A). European archives of psychiatry and clinical neuroscience 3 35796825
2021 Impact on the Risk and Severity of Childhood Onset Schizophrenia of Schizophrenia Risk Genetic Variants at the DRD2 and ZNF804A Loci. Child psychiatry and human development 3 34524581
2019 Data on association of the variation (rs1344706) in the ZNF804A gene with schizophrenia and its symptoms in the Russian population. Data in brief 3 31193559
2024 Impulsivity and aggression in alcohol withdrawal syndrome is modulated by the interaction of ZNF804A and mTOR polymorphism. Pharmacology, biochemistry, and behavior 2 38216065
2021 Polymorphism in the ZNF804A Gene and Variation in D1 and D2/D3 Dopamine Receptor Availability in the Healthy Human Brain: A Dual Positron Emission Tomography Study. Biological psychiatry. Cognitive neuroscience and neuroimaging 2 33712377
2021 Association Between ZNF804A Gene rs1344706 Polymorphism and Brain Functions in Healthy Individuals: A Systematic Review and Voxel-Based Meta-Analysis. Neuropsychiatric disease and treatment 2 34548792
2019 Family-based association study of ZNF804A polymorphisms and autism in a Han Chinese population. BMC psychiatry 2 31122238
2024 ANK3 rs10994336 and ZNF804A rs7597593 polymorphisms: genetic interaction for emotional and behavioral symptoms of alcohol withdrawal syndrome. BMC psychiatry 1 38702695
2021 rs1344706 polymorphism of zinc finger protein 804a (ZNF804a) gene related to the integrity of white matter fiber bundle in schizophrenics. Experimental and therapeutic medicine 1 34055077
2021 Association between rs1344706 Polymorphism in the ZNF804A Gene and the Risk for Schizophrenia. Iranian journal of psychiatry 1 35082850
2020 Genetic impact of ZNF804A on cognitive function in patients with bipolar I disorder. Psychiatric genetics 1 32941385
2023 Psychosis susceptibility zinc finger protein 804A (ZNF804A) gene polymorphism in schizophrenia patients treated with olanzapine in North Indian population. The International journal of neuroscience 0 33866919
2022 Genetic analysis of the ZNF804A gene in Mexican patients with schizophrenia, schizoaffective disorder and bipolar disorder. Gene 0 35447233