Affinage

ZDHHC3

Palmitoyltransferase ZDHHC3 · UniProt Q9NYG2

Length
299 aa
Mass
34.2 kDa
Annotated
2026-04-28
30 papers in source corpus 22 papers cited in narrative 23 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ZDHHC3 (GODZ) is a Golgi-resident DHHC-family protein S-acyltransferase (palmitoyltransferase) that catalyzes the transfer of palmitoyl groups to a broad spectrum of substrates, thereby controlling their membrane localization, stability, trafficking, and downstream signaling across neural, immune, metabolic, and viral contexts. The enzyme operates via a two-step mechanism in which the catalytic DHHC-motif cysteine (C157) first undergoes autoacylation before transferring the acyl chain to substrate cysteines, with two zinc ions coordinated by conserved cysteine-rich domain residues being essential for structural integrity and activity (PMID:26487721). In the CNS, ZDHHC3 palmitoylates the GABA(A) receptor γ2 subunit to promote its synaptic accumulation and GABAergic inhibitory transmission (PMID:15229235, PMID:27875292), palmitoylates NCAM under regulation by FGFR1/Src-mediated tyrosine phosphorylation to modulate neurite outgrowth (PMID:27247265), and palmitoylates Cadm4 at C347 to stabilize it at the plasma membrane and support CNS myelination and oligodendrocyte differentiation via WNT-β-Catenin signaling (PMID:39327467). Beyond the nervous system, ZDHHC3 palmitoylates diverse substrates including integrin α6β4 to control surface trafficking and Src signaling (PMID:22314500), PD-L1 to maintain its plasma membrane stability and enable tumor immune evasion (PMID:38237597), SCAP at C264 to antagonize ubiquitination and promote SREBP2-dependent cholesterol biosynthesis in a transcriptional positive feedback loop (PMID:39522165), IRHOM2 to block TRIM31-mediated degradation and promote NASH pathogenesis (PMID:37544908), and HSV-1 UL20 to facilitate viral glycoprotein trafficking and infectivity (PMID:28724772, PMID:29187538).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 2002 Medium

    Identification of ZDHHC3 as a Golgi-localized DHHC-domain protein that influences membrane protein trafficking established it as a candidate regulator of intracellular sorting.

    Evidence Overexpression in COS7 cells with immunofluorescence showing Golgi retention of GluRα1

    PMID:12163046

    Open questions at the time
    • No enzymatic activity demonstrated
    • Overexpression artifact not excluded
    • Endogenous substrates unknown
  2. 2004 High

    Demonstrating that ZDHHC3 palmitoylates the GABA(A) receptor γ2 subunit via a specific cytoplasmic loop domain established ZDHHC3 as a bona fide palmitoyltransferase with a defined neuronal substrate.

    Evidence Yeast two-hybrid, metabolic palmitoylation assay, domain-dependency mutagenesis in heterologous cells and neurons

    PMID:15229235

    Open questions at the time
    • In vivo relevance of GABA(A) receptor palmitoylation not yet shown
    • Substrate selectivity versus other DHHCs not addressed
  3. 2006 High

    Loss-of-function studies (dominant-negative C157S and RNAi) revealed that ZDHHC3 is selectively required for GABAergic synaptic receptor accumulation and inhibitory synaptic transmission, establishing its non-redundant role in synapse-type-specific function.

    Evidence Dominant-negative expression, RNAi, co-immunoprecipitation, electrophysiology in cultured neurons

    PMID:17151279

    Open questions at the time
    • Knockout animal model not yet generated
    • Mechanism of selective GABAergic versus glutamatergic distinction unclear
  4. 2012 High

    Identification of integrin α6β4 and TRAIL receptor DR4 as ZDHHC3 substrates expanded its functional scope beyond neurons to cell adhesion, signaling, and apoptosis, revealing that palmitoylation by ZDHHC3 controls surface delivery and lysosomal degradation of diverse transmembrane proteins.

    Evidence RNAi knockdown across multiple cell types for integrin; Y2H, mutagenesis, and apoptosis assays for DR4

    PMID:22240897 PMID:22314500

    Open questions at the time
    • DR4 palmitoylation site not directly mapped
    • In vivo validation of integrin and DR4 palmitoylation lacking
  5. 2015 High

    Biochemical reconstitution demonstrated that ZDHHC3 catalysis proceeds through autoacylation of the DHHC-motif cysteine, and that two zinc ions coordinated by conserved CRD cysteines are essential for structural integrity, establishing the enzymatic mechanism.

    Evidence Mass spectrometry detection of autoacylated intermediate, mutagenesis of CRD cysteines, metal chelation, zinc stoichiometry measurement

    PMID:26487721

    Open questions at the time
    • No high-resolution atomic structure
    • Acyl-chain selectivity mechanism unknown
    • Substrate recognition determinants not structurally defined
  6. 2016 High

    Three concurrent advances established (1) FGFR1/Src-mediated tyrosine phosphorylation as a regulatory mechanism controlling ZDHHC3 autopalmitoylation and NCAM palmitoylation, (2) in vivo knockout validation that ZDHHC3 and ZDHHC7 occupy distinct Golgi compartments explaining substrate specificity, and (3) Gsα as a substrate linking ZDHHC3 to meiotic cell cycle arrest.

    Evidence Phospho-site mutagenesis and kinase assays for NCAM regulation; GODZ KO mice with brain palmitoyl-proteomics and electrophysiology; Xenopus oocyte maternal RNA depletion for Gsα

    PMID:27247265 PMID:27512151 PMID:27875292

    Open questions at the time
    • Phosphorylation regulation not validated in vivo
    • Cis- vs trans-Golgi specificity structural basis unknown
    • Gsα pathway relevance in mammalian systems not demonstrated
  7. 2017 High

    ZDHHC3 was shown to palmitoylate HSV-1 UL20 protein, with loss of this palmitoylation disrupting viral glycoprotein surface expression and reducing viral infectivity, establishing ZDHHC3 as a host factor exploited by herpesviruses.

    Evidence Y2H, pulldown, dominant-negative GODZ, palmitoylation assay, virus titer measurement; subsequently confirmed in GODZ−/− MEFs and ocular infection model

    PMID:28724772 PMID:29187538

    Open questions at the time
    • Whether other DHHCs compensate in vivo not fully addressed
    • Mechanism of viral UL20 recognition by ZDHHC3 unknown
  8. 2017 High

    Identification of ERGIC3 palmitoylation by ZDHHC3 linked its enzymatic activity to cellular redox homeostasis: loss of ZDHHC3 upregulated TXNIP, elevated oxidative stress, and suppressed xenograft tumor growth, positioning ZDHHC3 as a cancer-relevant palmitoylation enzyme.

    Evidence ZDHHC3 ablation (RNAi/CRISPR) in xenografts, catalytic-dead reconstitution, gene array, oxidative stress assay

    PMID:29055014

    Open questions at the time
    • Direct palmitoylation site on ERGIC3 not mapped
    • Mechanism linking ERGIC3 palmitoylation to TXNIP expression unclear
  9. 2020 High

    Proteome-wide palmitoyl-proteomics identified 22–28 antioxidant/redox proteins as ZDHHC3 substrates, generalizing its role in redox homeostasis and demonstrating synergy between ZDHHC3 loss and chemotherapy.

    Evidence Comparative MS-based palmitoyl-proteomics in breast and prostate cancer cell lines with DHHC3 ablation

    PMID:32986127

    Open questions at the time
    • Most candidate substrates not individually validated
    • In vivo therapeutic relevance of combination strategy not tested
  10. 2023 High

    ZDHHC3 palmitoylation of IRHOM2 at C476 was shown to block TRIM31-mediated ubiquitin-proteasome degradation, with hepatocyte-specific ZDHHC3 deletion suppressing diet-induced NASH in rodents, linking ZDHHC3 to metabolic liver disease.

    Evidence Palmitoylation assay (acyl-RAC), mutagenesis of both enzyme and substrate, hepatocyte-specific KO mice, NASH diet models in mice and rabbits

    PMID:37544908

    Open questions at the time
    • Human relevance of ZDHHC3–IRHOM2 axis in NASH not demonstrated
    • Downstream IRHOM2 effectors mediating hepatic pathology incompletely defined
  11. 2024 High

    Multiple studies converged to define ZDHHC3 as a regulator of immune checkpoint (PD-L1), cholesterol metabolism (SCAP/SREBP2 feedback loop), CNS myelination (Cadm4/WNT-β-Catenin), and leukemia (PML/RARα), demonstrating that palmitoylation-dependent stabilization against lysosomal or proteasomal degradation is a unifying mechanism across substrates.

    Evidence PD-L1: enzymatic inhibitor BC with trafficking/degradation assays and tumor model; SCAP: mutagenesis of C264, ubiquitination assay, ChIP for SREBP2, HCC mouse model; Cadm4: ZDHHC3 KO and C347A KI mice with electrophysiology and behavioral tests; PML/RARα: KD/OE with differentiation assays

    PMID:38237597 PMID:39227737 PMID:39327467 PMID:39522165

    Open questions at the time
    • PML/RARα palmitoylation site not mapped
    • Relative contribution of ZDHHC3 vs ZDHHC7 to PD-L1 palmitoylation in vivo unclear
    • SCAP feedback loop not validated in human HCC tissue
  12. 2026 High

    ZDHHC3 was shown to S-acylate the small GTPase ARL15 at three N-terminal cysteines in a partially redundant manner with ZDHHC7, with loss of acylation redistributing ARL15 from membranes to the cytosol.

    Evidence APEGS assay, CRISPR KO, siRNA, cysteine mutagenesis, confocal imaging, subcellular fractionation

    PMID:41999893

    Open questions at the time
    • Functional consequence of ARL15 mislocalization not fully characterized
    • Redundancy with ZDHHC7 makes ZDHHC3-specific contribution hard to isolate in vivo

Open questions

Synthesis pass · forward-looking unresolved questions
  • A high-resolution atomic structure of ZDHHC3 in complex with a substrate or acyl-CoA is still lacking, and the structural determinants of its broad but selective substrate recognition remain undefined.
  • No atomic-resolution structure available
  • Substrate recognition code not defined
  • Tissue-specific regulation of ZDHHC3 expression and activity incompletely understood

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016740 transferase activity 14
Localization
GO:0005794 Golgi apparatus 3
Pathway
R-HSA-112316 Neuronal System 4 R-HSA-162582 Signal Transduction 4 R-HSA-392499 Metabolism of proteins 4 R-HSA-1430728 Metabolism 1 R-HSA-168256 Immune System 1
Partners
ARL15CADM4CD274GABRG2IRHOM2ITGB4NCAM1SCAP

Evidence

Reading pass · 23 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2002 GODZ (ZDHHC3) is a Golgi apparatus-specific protein with a DHHC zinc finger domain and four putative transmembrane regions; overexpression in COS7 cells suppressed sorting of glutamate receptor GluRα1 from the Golgi apparatus, implicating ZDHHC3 in membrane protein trafficking. Overexpression in COS7 cells, subcellular localization by immunofluorescence Biochemical and biophysical research communications Medium 12163046
2004 ZDHHC3 (GODZ) was identified as a palmitoyltransferase that palmitoylates the γ2 subunit of GABA(A) receptors via interaction with a conserved 14-amino acid cysteine-rich domain in the large cytoplasmic loop of γ1-3 subunits; GODZ localizes to the Golgi complex in neurons and its coexpression with GABA(A) receptors in heterologous cells results in γ2 palmitoylation in a cytoplasmic loop domain-dependent manner. SOS-recruitment yeast two-hybrid, coexpression in heterologous cells, metabolic palmitoylation assay, immunofluorescence localization The Journal of neuroscience High 15229235
2006 ZDHHC3 (GODZ) and its paralog SERZ-β (ZDHHC7) form homomultimers and heteromultimers; GODZ is required for normal synaptic accumulation of GABA(A) receptors, whole-cell and synaptic GABAergic inhibitory function, and GABAergic innervation, but is dispensable for postsynaptic AMPA receptor-mediated glutamatergic transmission; dominant-negative GODZ (C157S) and GODZ-specific RNAi established these requirements. Coimmunoprecipitation, in vivo cross-linking, dominant-negative expression (GODZ C157S), plasmid-based RNAi, electrophysiology in neurons The Journal of neuroscience High 17151279
2009 ZDHHC3 (GODZ) mediates Ca2+ transport in Xenopus oocytes in a palmitoylation-dependent manner; mutation of the DHHC motif (GODZ-DHHS) or treatment with palmitoylation inhibitor 2-bromopalmitate reduced Ca2+ transport ~80%; a separate V61R mutation abolished Ca2+ transport without affecting palmitoyl acyltransferase activity, indicating dual functions. Two-electrode voltage-clamp, fluorescence assay, 45Ca2+ isotopic uptake in Xenopus oocytes, site-directed mutagenesis, immunocytochemistry The Journal of biological chemistry Medium 19955568
2012 ZDHHC3 (DHHC3) is the enzyme responsible for palmitoylation of integrin α6 and β4 subunits; DHHC3 ablation markedly diminished integrin-dependent cellular cable formation on Matrigel, integrin signaling through Src, β4 phosphorylation at S1356 and S1424, and accelerated lysosomal degradation of α6β4 via increased cathepsin D exposure; rescued α6β4 accumulated intracellularly and could not reach the cell surface. RNAi knockdown, overexpression in multiple cell types, palmitoylation assay, Matrigel cable formation assay, phosphorylation analysis, lysosomal inhibitor (Pepstatin A) rescue Cellular and molecular life sciences High 22314500
2012 ZDHHC3 (GODZ) interacts with the death domain of TRAIL receptor DR4 (but not DR5) through its DHHC and C-terminal transmembrane domains, localizes DR4 to the plasma membrane, and regulates TRAIL/DR4-mediated apoptosis; mutation of the cysteine-rich motif of DR4 causes mistargeting and attenuates TRAIL-mediated apoptosis. SOS protein recruitment-yeast two-hybrid screening, pulldown, cell surface localization assay, apoptosis assay, DR4 cysteine mutagenesis Cell death and differentiation Medium 22240897
2015 ZDHHC3 undergoes autoacylation (palmitoylation) at the cysteine within the DHHC motif, as shown by mass spectrometry; conserved cysteines outside the DHHC motif coordinate two zinc ions per DHHC3 molecule, and chelation or mutation of these cysteines disrupts CRD structural integrity and causes enzymatic activity deficits. Mass spectrometry, site-directed mutagenesis of conserved CRD cysteines, limited proteolysis, metal chelation in vitro, fluorescent zinc indicator (mag-fura-2) stoichiometry measurement The Journal of biological chemistry High 26487721
2016 ZDHHC3 palmitoylates the neural cell adhesion molecule NCAM, and this activity is regulated by tyrosine phosphorylation: FGFR1 phosphorylates Tyr18 and Src phosphorylates Tyr295/Tyr297 of ZDHHC3; abrogation of these phosphorylation sites increased ZDHHC3 autopalmitoylation, enhanced interaction with NCAM, upregulated NCAM palmitoylation, and promoted neurite outgrowth in hippocampal neurons. Site-directed mutagenesis, pharmacological inhibition of FGFR and Src, cell-based and cell-free kinase assays, coimmunoprecipitation, neurite outgrowth assay in hippocampal neurons Molecular and cellular biology High 27247265
2016 In GODZ knockout mice, palmitoylation of γ2 GABA(A) receptor subunit and GAP-43 (growth-associated protein 43 kDa) was significantly reduced in brain; synaptic accumulation of GABA(A) receptors and GABAergic synaptic function were selectively reduced in GODZ KO neurons when competing with wild-type neurons; GODZ and SERZ-β localize to distinct cis- versus trans-Golgi compartments, explaining their different in vivo substrate specificities. Knockout mice (GODZ KO, SERZ-β KO, double KO), palmitoylation assay in brain, electrophysiology, immunocytochemistry, subcellular fractionation The Journal of biological chemistry High 27875292
2016 ZDHHC3 palmitoylates Gsα in Xenopus oocytes to maintain meiotic arrest at G2 phase; specific palmitoylation sites on Gsα were mapped, palmitoylation-deficient Gsα failed to maintain G2 arrest, and a critical ZDHHC3 residue required for its palmitoylation activity toward Gsα was identified; ZDHHC3 functions downstream of acsl1b in this pathway. Maternal RNA depletion in Xenopus oocytes, meiotic arrest assay, site-directed mutagenesis of Gsα palmitoylation sites and ZDHHC3 catalytic residue, progesterone threshold assay Biology of reproduction Medium 27512151
2017 HSV-1 UL20 protein binds specifically to ZDHHC3 (GODZ) via two-hybrid and pulldown assays; ZDHHC3 palmitoylates UL20, and this palmitoylation is required for proper membrane targeting of UL20 and subsequent gK cell surface expression and HSV-1 infectivity; dominant-negative GODZ (C157S) and 2-bromopalmitate treatment reduced HSV-1 titers and altered UL20/gK localization. Yeast two-hybrid, pulldown assay, dominant-negative GODZ expression, palmitoylation assay, virus titer measurement, immunofluorescence Journal of virology High 28724772
2017 ZDHHC3 palmitoylates ERGIC3, and loss of DHHC3-dependent palmitoylation of ERGIC3 leads to upregulation of TXNIP, increased oxidative stress, and senescence in tumor cells; DHHC3 ablation reduced xenograft tumor growth and metastasis, and these effects required enzymatic activity (wild-type but not active-site-deficient DHHC3 reconstituted activity). ZDHHC3 ablation (RNAi/CRISPR) in MDA-MB-231 xenografts, gene array, fluorescence oxidative stress assay, reconstitution with WT vs. catalytic-dead ZDHHC3, concomitant TXNIP ablation Cancer research High 29055014
2018 In GODZ−/− murine embryonic fibroblasts, HSV-1 replication is compromised: GODZ absence blocks palmitoylation of viral UL20, alters localization and expression of UL20, gK, gB, gC, and tegument/capsid proteins, and limits virion maturation at multiple steps as shown by electron microscopy; in vivo, ocularly infected GODZ−/− mice showed reduced corneal scarring and reduced HSV-1 latency reactivation. GODZ−/− knockout mouse-derived MEFs, palmitoylation assay, electron microscopy, immunofluorescence, in vivo ocular infection model Journal of virology High 29187538
2020 Mass spectrometry-based palmitoyl-proteomic analysis identified 22–28 antioxidant/redox-regulatory proteins as candidate ZDHHC3 substrates; DHHC3 ablation elevated oxidative stress and, combined with chemotherapeutic drug treatment, synergistically enhanced anti-growth effects, establishing DHHC3 as a regulator of antioxidant protein palmitoylation and cellular redox homeostasis. Comparative mass spectrometry-based palmitoyl-proteomics, DHHC3 ablation in breast and prostate cancer cell lines, fluorescence oxidative stress assays, cell proliferation assays Cellular and molecular life sciences High 32986127
2021 A high-throughput Acyl-cLIP enzymatic assay for ZDHHC3 (as well as ZDHHC7 and ZDHHC20) was developed and validated; in vitro Acyl-cLIP results were confirmed by cell-based palmitoylation assays, enabling inhibitor screening. Acylation-coupled lipophilic induction of polarization (Acyl-cLIP) in vitro assay, cell-based palmitoylation assay validation ACS chemical biology Medium 34374518
2022 Structural exploration of human DHHC3 identified LAMTOR1 as an interacting protein by mass spectrometry and co-immunoprecipitation; cryo-EM imaging of the inactive hDHHS3 mutant showed a typical membrane protein side-view, providing initial structural characterization of DHHC3. Protein expression/purification, mass spectrometry, co-immunoprecipitation, cryo-EM Polymers Low 35893977
2023 ZDHHC3 palmitoylates IRHOM2 at C476 within the iRhom homology domain, facilitating IRHOM2 cytomembrane translocation and stabilization; palmitoylation by ZDHHC3 (via its C157 DHHC domain) blocks TRIM31-mediated ubiquitin-proteasome degradation of IRHOM2; fatty acid challenge increases ZDHHC3–IRHOM2 association and IRHOM2 palmitoylation; hepatocyte-specific ZDHHC3 deletion suppresses NASH pathology in rodent and rabbit models. Co-immunoprecipitation, palmitoylation assay (acyl-RAC), site-directed mutagenesis (C476, C157), hepatocyte-specific KO mice, in vivo diet-induced NASH models, ubiquitination assay Advanced science High 37544908
2024 ZDHHC3 palmitoylates PD-L1, maintaining its membrane stability; inhibition of ZDHHC3 enzymatic activity by benzosceptrin C (BC) prevents PD-L1 palmitoylation, causing PD-L1 to be transferred from the membrane to the cytoplasm where it cannot recycle via recycling endosomes and undergoes lysosome-mediated degradation. Cell-based palmitoylation assay, ZDHHC3 enzymatic inhibition by small molecule BC, flow cytometry and imaging of PD-L1 trafficking, T cell cytotoxicity assay, in vivo MC38 tumor model Cell reports. Medicine High 38237597
2024 ZDHHC3 S-acylates SCAP at C264, antagonizing HACE1-mediated SCAP ubiquitination and thereby promoting SCAP/SREBP2 signaling and cholesterol biosynthesis in HCC; SREBP2 transcriptionally upregulates ZDHHC3, forming a positive feedback loop; ABHD17A acts as the depalmitoylase counteracting ZDHHC3 on SCAP. Co-immunoprecipitation, palmitoylation assay, site-directed mutagenesis (C264), ubiquitination assay, chromatin immunoprecipitation (SREBP2), ZDHHC3 KO/overexpression, in vivo DEN/CCl4 HCC mouse model Cell reports High 39522165
2024 ZDHHC3 palmitoylates PML/RARα oncofusion protein, and this palmitoylation regulates its oncogenic transcriptional activity and APL pathogenesis; knockdown or overexpression of ZDHHC3 respectively decreased or increased expression of proliferation- and differentiation-related genes; ZDHHC3 depletion or inhibition arrested malignant progression including in drug-resistant APL. Palmitoylation assay, ZDHHC3 knockdown/overexpression, gene expression analysis, APL cell differentiation/proliferation assays Acta pharmacologica Sinica Medium 39227737
2024 ZDHHC3 is required for palmitoylation of Cadm4 at C347, which stabilizes Cadm4 at the plasma membrane; genetic deletion of ZDHHC3 reduces Cadm4 palmitoylation and causes CNS myelination defects (loss, demyelination, hypermyelination) phenocopying C347A Cadm4 knock-in mice; altered Cadm4 palmitoylation impairs neuronal transmission, cognitive behaviors, and modulates WNT-β-Catenin–dependent oligodendrocyte differentiation. ZDHHC3 KO mice, Cadm4 C347A knock-in mice, palmitoylation assay, immunofluorescence, electrophysiology, behavioral tests, WNT-β-Catenin pathway analysis Signal transduction and targeted therapy High 39327467
2024 IL-1α signaling in precancerous epithelial dysplasia represses expression of DHHC3 (and DHHC7), enzymes responsible for palmitoylation of STING, thereby reducing STING-mediated type-I interferon signaling in myeloid cells. Genetically engineered mouse model, longitudinal human specimens, gene expression analysis, IL-1 blockade (pharmacological and genetic) bioRxiv (preprint)preprint Low
2026 ZDHHC3 and ZDHHC7 mediate S-acylation of the small GTPase ARL15 at three conserved N-terminal cysteine residues (Cys17, Cys22, Cys23) in a partially redundant manner; loss of S-acylation disrupts ARL15 membrane association and redistributes it to the cytosol. APEGS assay, siRNA knockdown, CRISPR/Cas9 gene disruption, confocal imaging, subcellular fractionation, cysteine-to-serine mutagenesis The Journal of biological chemistry High 41999893

Source papers

Stage 0 corpus · 30 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2004 The gamma2 subunit of GABA(A) receptors is a substrate for palmitoylation by GODZ. The Journal of neuroscience : the official journal of the Society for Neuroscience 203 15229235
2006 GODZ-mediated palmitoylation of GABA(A) receptors is required for normal assembly and function of GABAergic inhibitory synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience 137 17151279
2017 Protein Acyltransferase DHHC3 Regulates Breast Tumor Growth, Oxidative Stress, and Senescence. Cancer research 67 29055014
2024 Benzosceptrin C induces lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting DHHC3. Cell reports. Medicine 65 38237597
2022 ALKBH5 promotes PD-L1-mediated immune escape through m6A modification of ZDHHC3 in glioma. Cell death discovery 62 36566230
2002 Isolation and characterization of Golgi apparatus-specific GODZ with the DHHC zinc finger domain. Biochemical and biophysical research communications 50 12163046
2015 The Cysteine-rich Domain of the DHHC3 Palmitoyltransferase Is Palmitoylated and Contains Tightly Bound Zinc. The Journal of biological chemistry 49 26487721
2012 Palmitoylation by DHHC3 is critical for the function, expression, and stability of integrin α6β4. Cellular and molecular life sciences : CMLS 49 22314500
2016 ZDHHC3 Tyrosine Phosphorylation Regulates Neural Cell Adhesion Molecule Palmitoylation. Molecular and cellular biology 39 27247265
2016 Dissociation of Golgi-associated DHHC-type Zinc Finger Protein (GODZ)- and Sertoli Cell Gene with a Zinc Finger Domain-β (SERZ-β)-mediated Palmitoylation by Loss of Function Analyses in Knock-out Mice. The Journal of biological chemistry 36 27875292
2012 Regulation in the targeting of TRAIL receptor 1 to cell surface via GODZ for TRAIL sensitivity in tumor cells. Cell death and differentiation 31 22240897
2023 Palmitoyltransferase ZDHHC3 Aggravates Nonalcoholic Steatohepatitis by Targeting S-Palmitoylated IRHOM2. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 28 37544908
2024 ZDHHC3-mediated SCAP S-acylation promotes cholesterol biosynthesis and tumor immune escape in hepatocellular carcinoma. Cell reports 27 39522165
2021 High-Throughput Enzyme Assay for Screening Inhibitors of the ZDHHC3/7/20 Acyltransferases. ACS chemical biology 21 34374518
2018 The Absence of DHHC3 Affects Primary and Latent Herpes Simplex Virus 1 Infection. Journal of virology 20 29187538
2009 Golgi-specific DHHC zinc finger protein GODZ mediates membrane Ca2+ transport. The Journal of biological chemistry 19 19955568
2017 Binding of Herpes Simplex Virus 1 UL20 to GODZ (DHHC3) Affects Its Palmitoylation and Is Essential for Infectivity and Proper Targeting and Localization of UL20 and Glycoprotein K. Journal of virology 18 28724772
2020 Antioxidant functions of DHHC3 suppress anti-cancer drug activities. Cellular and molecular life sciences : CMLS 17 32986127
2024 Treating ICB-resistant cancer by inhibiting PD-L1 via DHHC3 degradation induced by cell penetrating peptide-induced chimera conjugates. Cell death & disease 16 39349454
2024 Palmitoylation regulates myelination by modulating the ZDHHC3-Cadm4 axis in the central nervous system. Signal transduction and targeted therapy 15 39327467
2024 Palmitoyltransferase ZDHHC3 is essential for the oncogenic activity of PML/RARα in acute promyelocytic leukemia. Acta pharmacologica Sinica 9 39227737
2023 Changes in miR-134-3p expression and zDHHC3-AMPARs axis in association with aluminum neurotoxicity. Environmental science and pollution research international 8 37495815
2024 zDHHC3-mediated S-palmitoylation of SLC9A2 regulates apoptosis in kidney clear cell carcinoma. Journal of cancer research and clinical oncology 7 38619631
2017 ZDHHC3 as a Risk and Mortality Marker for Breast Cancer in African American Women. Cancer informatics 6 29276372
2025 ZDHHC3-LYPLA1 regulates PRRSV-2 replication through reversible palmitoylation. Veterinary microbiology 5 39787744
2016 Involvement of Protein Acyltransferase ZDHHC3 in Maintaining Oocyte Meiotic Arrest in Xenopus laevis. Biology of reproduction 5 27512151
2022 Recent progress of palmitoyl transferase DHHC3 as a novel antitumor target. Future medicinal chemistry 4 35134300
2022 Antioxidant and Anticancer Functions of Protein Acyltransferase DHHC3. Antioxidants (Basel, Switzerland) 4 35624824
2022 Structural Exploration on Palmitoyltransferase DHHC3 from Homo sapiens. Polymers 3 35893977
2026 S-acylation and membrane localization of the small GTPase ARL15 are mediated by the Golgi S-acyltransferases ZDHHC7 and ZDHHC3. The Journal of biological chemistry 0 41999893