Affinage

ZDHHC3

Palmitoyltransferase ZDHHC3 · UniProt Q9NYG2

Length
299 aa
Mass
34.2 kDa
Annotated
2026-06-11
32 papers in source corpus 23 papers cited in narrative 23 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ZDHHC3 (GODZ) is a Golgi-resident DHHC-family palmitoyl acyltransferase that S-acylates a broad set of membrane and signaling proteins to control their membrane targeting, stability, and downstream function (PMID:12163046, PMID:15229235). Catalysis proceeds through a two-step mechanism: ZDHHC3 first autoacylates the cysteine within its DHHC motif, and conserved cysteines outside this motif coordinate two zinc ions required for structural integrity and enzymatic activity (PMID:26487721). Its activity is tuned by FGFR1/Src-mediated tyrosine phosphorylation at Tyr18, Tyr295, and Tyr297, which when abolished increases autopalmitoylation and substrate modification (PMID:27247265). In the nervous system ZDHHC3 palmitoylates the GABA(A) receptor γ2 subunit through a cytoplasmic cysteine-rich loop, selectively controlling the synaptic receptor pool and GABAergic innervation (PMID:15229235, PMID:17151279, PMID:27875292), and palmitoylates Cadm4 to stabilize its plasma-membrane localization in oligodendrocytes, supporting CNS myelination (PMID:39327467). A recurrent mechanistic theme is that ZDHHC3-mediated palmitoylation stabilizes substrates by antagonizing their degradation: it protects integrin α6β4 from lysosomal turnover (PMID:22314500), blocks TRIM31-mediated ubiquitination of IRHOM2 (PMID:37544908), antagonizes HACE1-mediated ubiquitination of SCAP within an SREBP2 positive-feedback loop sustaining cholesterol biosynthesis (PMID:39522165), and prevents lysosomal degradation of PD-L1 to modulate antitumor immunity (PMID:38237597). ZDHHC3 also palmitoylates viral proteins required for replication, including HSV-1 UL20 (PMID:28724772, PMID:29187538) and the PRRSV nucleocapsid protein (PMID:39787744), and modifies the PML/RARα oncofusion protein and the circadian repressor CRY1 (PMID:39227737, PMID:42239456). Substrate breadth is supported by palmitoyl-proteomic surveys identifying numerous redox-regulatory candidate substrates (PMID:32986127).

Mechanistic history

Synthesis pass · year-by-year structured walk · 15 steps
  1. 2002 Medium

    Established ZDHHC3 as a Golgi-specific DHHC-domain protein involved in membrane protein trafficking, framing where and on what class of proteins it acts.

    Evidence Overexpression and immunofluorescence localization in COS7 cells with a GluRα1 sorting phenotype

    PMID:12163046

    Open questions at the time
    • No catalytic-site mutagenesis or reconstitution
    • Enzymatic palmitoylation activity not yet demonstrated
  2. 2004 High

    Identified the first defined substrate, the GABA(A) receptor γ2 subunit, establishing ZDHHC3 as a bona fide palmitoyl acyltransferase acting through a substrate cysteine-rich domain.

    Evidence Yeast two-hybrid interaction plus cell-based palmitoylation assay and Golgi localization in neurons

    PMID:15229235

    Open questions at the time
    • In vitro reconstitution with purified components absent
    • Physiological consequence at synapses not yet tested
  3. 2006 High

    Demonstrated that ZDHHC3 oligomerizes and is the primary enzyme controlling synaptic GABA(A) receptor accumulation, linking palmitoylation to inhibitory synaptic function.

    Evidence Co-IP, cross-linking, neuronal RNAi, dominant-negative C157S, and electrophysiology

    PMID:17151279

    Open questions at the time
    • Functional role of homo/heteromultimerization unresolved
    • Redundancy with DHHC7 not fully delineated
  4. 2009 Medium

    Showed a palmitoylation-independent Ca2+ transport function separable from acyltransferase activity, raising the possibility of a second molecular role.

    Evidence Voltage clamp, Ca2+ imaging and 45Ca uptake in Xenopus oocytes with V61R vs DHHS mutants

    PMID:19955568

    Open questions at the time
    • Single lab, no replication
    • Physiological relevance in mammalian cells unknown
  5. 2012 High

    Generalized ZDHHC3 substrate scope beyond neurons (integrin α6β4, TRAIL receptor DR4) and revealed that palmitoylation protects substrates from degradation and shapes their membrane localization and signaling.

    Evidence RNAi, overexpression, palmitoylation and Src signaling assays, cathepsin D rescue, Co-IP, apoptosis assays

    PMID:22240897 PMID:22314500

    Open questions at the time
    • Whether DR4 effect requires palmitoylation per se vs interaction not fully separated
    • Selectivity determinants among integrin subunits unexplained
  6. 2015 High

    Defined the catalytic chemistry: autoacylation at the DHHC cysteine plus zinc coordination by conserved CRD cysteines required for activity and structure.

    Evidence Mass spectrometry, CRD cysteine mutagenesis, limited proteolysis, EDTA chelation, zinc quantification

    PMID:26487721

    Open questions at the time
    • No high-resolution structure of the enzyme
    • Transacylation step kinetics not resolved
  7. 2016 High

    In vivo genetics confirmed substrate selectivity (synaptic GABA(A) receptor pool, GAP-43) and uncovered tyrosine phosphorylation by FGFR1/Src as a regulatory input controlling autopalmitoylation and NCAM modification.

    Evidence GODZ/SERZ-β knockout mice with palmitoylation, electrophysiology, and fractionation; kinase assays and tyrosine-site mutagenesis with neurite outgrowth

    PMID:27247265 PMID:27875292

    Open questions at the time
    • How phosphorylation alters enzyme conformation unknown
    • Upstream signals coupling FGFR/Src to ZDHHC3 in vivo unmapped
  8. 2016 Medium

    Extended the substrate repertoire to Gsα in a developmental context, linking ZDHHC3 to meiotic arrest control downstream of acsl1b.

    Evidence Morpholino depletion, mutagenesis, palmitoylation assay and progesterone dose-response in Xenopus oocytes

    PMID:27512151

    Open questions at the time
    • Single lab, Xenopus model
    • Mammalian relevance untested
  9. 2017 High

    Established ZDHHC3 as a host factor for HSV-1 by palmitoylating UL20, required for viral glycoprotein localization and replication, validated genetically and in vivo.

    Evidence Yeast two-hybrid, pulldown, acyl-RAC, dominant-negative and KO-MEF/mouse ocular infection models

    PMID:28724772 PMID:29187538

    Open questions at the time
    • UL20 palmitoylation site not pinpointed in the narrative
    • Whether targeting ZDHHC3 is therapeutically tractable against HSV-1 untested
  10. 2017 Medium

    Connected ZDHHC3 palmitoylation (of ERGIC3) to redox homeostasis and tumor suppression via a TXNIP-dependent oxidative-stress axis.

    Evidence Catalytic-mutant reconstitution, gene array, oxidative stress assays, xenograft, TXNIP co-depletion

    PMID:29055014

    Open questions at the time
    • Single lab
    • Direct ERGIC3 palmitoylation site not mapped
  11. 2020 Medium

    Palmitoyl-proteomics broadened the candidate substrate landscape toward antioxidant/redox proteins and linked ZDHHC3 loss to chemosensitization.

    Evidence Comparative MS palmitoyl-proteomics with RNAi and proliferation assays in cancer cells

    PMID:32986127

    Open questions at the time
    • Candidate substrates not individually validated as direct
    • Mechanism of synergy with chemotherapy unresolved
  12. 2021 Medium

    Provided a quantitative high-throughput assay enabling enzymatic screening of ZDHHC3, supporting drug-discovery efforts.

    Evidence Acyl-cLIP assay validated against cell-based palmitoylation for ZDHHC3/7/20

    PMID:34374518

    Open questions at the time
    • Assay development, not a biological discovery
    • Selectivity over other DHHC enzymes limited
  13. 2023 High

    Defined a stability-control paradigm in metabolic disease: ZDHHC3 palmitoylates IRHOM2 at C476 to block TRIM31 ubiquitination, driving NASH pathology.

    Evidence Co-IP, dual enzyme/substrate mutagenesis, acyl-RAC, ubiquitination assay, hepatocyte-specific KO in rodent and rabbit NASH models

    PMID:37544908

    Open questions at the time
    • Structural basis of palmitoyl-ubiquitin antagonism unknown
    • Generality of the ubiquitination-antagonism mechanism across substrates not formalized
  14. 2024 High

    Consolidated the degradation-antagonism mechanism across diverse pathways: PD-L1 (immunity), SCAP (cholesterol biosynthesis feedback), Cadm4 (myelination), and PML/RARα (leukemia oncogenicity).

    Evidence Site mutagenesis, palmitoylation/ubiquitination assays, ChIP, lysosomal rescue, KO and knock-in mice, and in vivo tumor/myelination models

    PMID:38237597 PMID:39227737 PMID:39327467 PMID:39522165

    Open questions at the time
    • Determinants of substrate selectivity across these targets not unified
    • Whether a single inhibitor can disentangle these roles therapeutically untested
  15. 2026 Medium

    Expanded substrates to membrane-targeting of the GTPase ARL15 (with ZDHHC7) and to nuclear import and repressor function of circadian CRY1, broadening ZDHHC3 roles into trafficking and clock regulation.

    Evidence APEGS, cysteine mutagenesis, siRNA/CRISPR for ARL15; palmitoylation screen, mutagenesis, DHHC3 deletion and circadian reporter for CRY1 (preprint)

    PMID:41999893 PMID:42239456

    Open questions at the time
    • CRY1 finding is a preprint awaiting peer review
    • How a Golgi enzyme controls nuclear CRY1 import mechanistically unclear

Open questions

Synthesis pass · forward-looking unresolved questions
  • How ZDHHC3 achieves substrate selectivity among its many targets, and whether its various disease-relevant roles can be separated pharmacologically, remains unresolved.
  • No high-resolution enzyme-substrate structure
  • Substrate recognition code undefined
  • Selectivity of available small-molecule inhibitors across DHHC enzymes incomplete

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016740 transferase activity 7 GO:0140096 catalytic activity, acting on a protein 5 GO:0016787 hydrolase activity 1
Localization
GO:0005794 Golgi apparatus 3
Pathway
R-HSA-112316 Neuronal System 4 R-HSA-392499 Metabolism of proteins 4 R-HSA-1430728 Metabolism 1 R-HSA-168256 Immune System 1 R-HSA-9909396 Circadian clock 1
Partners
CADM4GABRG2IRHOM2ITGA6ITGB4NCAM1SCAPZDHHC7

Evidence

Reading pass · 23 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2002 GODZ (ZDHHC3) is a Golgi apparatus-specific protein with a DHHC zinc finger domain and four putative transmembrane regions; overexpression in COS7 cells suppressed sorting of the glutamate receptor GluRα1 from the Golgi apparatus, implicating ZDHHC3 in membrane protein trafficking. Overexpression in COS7 cells, subcellular localization by immunofluorescence Biochemical and biophysical research communications Medium 12163046
2004 ZDHHC3 (GODZ) palmitoylates the γ2 subunit of GABA(A) receptors via a cytoplasmic loop cysteine-rich 14-amino acid domain conserved in γ1-3 subunits; ZDHHC3 is localized asymmetrically in the neuronal Golgi complex and interacts with γ2 through the SOS-recruitment (yeast two-hybrid) system. SOS-recruitment yeast two-hybrid, coexpression in heterologous cells with palmitoylation assay, subcellular localization by immunofluorescence The Journal of neuroscience High 15229235
2006 ZDHHC3 and its paralog SERZ-β (DHHC7) form homomultimers and heteromultimers; ZDHHC3 is the primary enzyme palmitoylating the GABA(A) receptor γ2 subunit, and dominant-negative ZDHHC3 (C157S) or ZDHHC3 RNAi reduces GABA(A) receptor accumulation at inhibitory synapses and impairs GABAergic synaptic function without affecting AMPA receptor-mediated transmission. Co-immunoprecipitation, in vivo cross-linking, RNAi knockdown in neurons, dominant-negative overexpression, whole-cell and synaptic electrophysiology The Journal of neuroscience High 17151279
2009 ZDHHC3 mediates Ca²⁺ transport when expressed in Xenopus oocytes; this transport is dependent on palmitoylation activity (abolished by 2-bromopalmitate or DHHC→DHHS active-site mutation by ~80%), but a separate V61R mutation abolishes Ca²⁺ transport without affecting palmitoyl acyltransferase activity, indicating the two functions are separable. Two-electrode voltage clamp, fluorescence Ca²⁺ imaging, ⁴⁵Ca²⁺ isotopic uptake in Xenopus oocytes, site-directed mutagenesis The Journal of biological chemistry Medium 19955568
2012 ZDHHC3 is the palmitoyltransferase responsible for palmitoylation of integrin β4 and α6 subunits; DHHC3 ablation accelerates lysosomal degradation of α6β4 via increased cathepsin D exposure, impairs integrin signaling through Src, reduces β4 phosphorylation at S1356 and S1424, and blocks integrin-dependent cable formation on Matrigel, while ~10 other cell-surface proteins including α3β1 are unaffected. RNAi knockdown, overexpression in multiple cell lines, palmitoylation assay, Src signaling/phosphorylation assays, cathepsin D inhibitor rescue (Pepstatin A), cell-surface biotinylation Cellular and molecular life sciences High 22314500
2012 ZDHHC3 interacts with the death domain of TRAIL receptor DR4 (but not DR5) through its DHHC and C-terminal transmembrane domains, and promotes localization of DR4 to the plasma membrane via the DHHC motif, thereby sensitizing tumor cells to TRAIL-induced apoptosis. SOS protein-recruitment yeast two-hybrid, co-immunoprecipitation, subcellular localization assay, apoptosis assays, cysteine mutagenesis of DR4 Cell death and differentiation Medium 22240897
2015 ZDHHC3 undergoes autoacylation (palmitoylation) at the cysteine within the DHHC motif; conserved cysteines outside the DHHC motif coordinate two zinc ions per ZDHHC3 molecule, and mutation of these cysteines or chelation of zinc by EDTA causes structural perturbation and loss of palmitoyl acyltransferase activity. Mass spectrometry identification of palmitoylation site, site-directed mutagenesis of conserved CRD cysteines, limited proteolysis, metal chelation with EDTA, zinc quantification using fluorescent indicator mag-fura-2 The Journal of biological chemistry High 26487721
2016 In GODZ (ZDHHC3) knockout mice, palmitoylation of γ2 subunit of GABA(A) receptors and GAP-43 is significantly reduced; GABA(A) receptor synaptic accumulation and GABAergic innervation are decreased in GODZ KO neurons competing with wild-type neurons; total cell-surface GABA(A) receptor expression and whole-cell GABAergic currents are unaltered in isolated DKO neurons, indicating GODZ-mediated palmitoylation selectively controls the synaptic pool of receptors. SERZ-β (DHHC7) KO alone does not affect γ2 palmitoylation. Knockout mice (GODZ KO, SERZ-β KO, double KO), palmitoylation assay, electrophysiology, immunofluorescence, subcellular fractionation The Journal of biological chemistry High 27875292
2016 ZDHHC3 is phosphorylated by FGFR1 at Tyr18 and by Src kinase at Tyr295 and Tyr297; abrogation of these tyrosine phosphorylation sites increases ZDHHC3 autopalmitoylation, enhances interaction with NCAM, upregulates NCAM palmitoylation, and promotes neurite outgrowth in hippocampal neurons. Pharmacological inhibition and overexpression of FGFR/Src, site-directed mutagenesis of ZDHHC3 tyrosines, cell-free and cell-based kinase assays, palmitoylation assay, co-immunoprecipitation, neurite outgrowth assay Molecular and cellular biology High 27247265
2016 ZDHHC3 functions downstream of acsl1b to palmitoylate Gsα at mapped cysteine residues in Xenopus oocytes, maintaining meiotic G2/prophase I arrest; depletion of ZDHHC3 reduces palmitoylated Gsα levels and lowers the progesterone threshold for G2/M transition from 2 μM to 0.01 μM. RNA depletion (antisense morpholino) in Xenopus oocytes, palmitoylation assay, site-directed mutagenesis of Gsα palmitoylation sites and ZDHHC3 active site, progesterone dose-response assay Biology of reproduction Medium 27512151
2017 ZDHHC3 palmitoylates ERGIC3 protein; loss of ZDHHC3-dependent palmitoylation of ERGIC3 leads to upregulation of TXNIP, increased oxidative stress, and cellular senescence in breast cancer cells; these antitumor effects are reversed by wild-type but not enzyme-active-site-deficient ZDHHC3, and are substantially negated by co-depletion of TXNIP. RNAi ablation, wild-type vs. catalytic mutant ZDHHC3 reconstitution, gene array, fluorescence dye oxidative stress assays, xenograft tumor model, flow cytometry for immune cell recruitment Cancer research Medium 29055014
2017 ZDHHC3 binds specifically to HSV-1 UL20 (but not other HSV-1 proteins) in the Golgi apparatus via yeast two-hybrid and pulldown assays, palmitoylates UL20 (blocked by dominant-negative ZDHHC3 C157S or 2-bromopalmitate), and is required for proper localization of UL20 and glycoprotein K (gK) and for HSV-1 replication in vitro. Yeast two-hybrid, pulldown assay, dominant-negative ZDHHC3 overexpression, palmitoylation assay (acyl-RAC), 2-bromopalmitate inhibition, immunofluorescence localization, viral titer assay Journal of virology High 28724772
2018 In ZDHHC3 (GODZ) knockout MEFs, HSV-1 replication is compromised; ZDHHC3 absence blocks UL20 palmitoylation, alters localization and expression of UL20 and gK, affects expression of gB and gC, and disrupts tegument/capsid protein localization; in vivo, GODZ KO mice show reduced corneal HSV-1 replication, lower corneal scarring, and reduced latency reactivation. GODZ KO mouse-derived MEFs, palmitoylation assay, electron microscopy, immunofluorescence, viral titer, in vivo ocular infection model Journal of virology High 29187538
2020 Comparative mass spectrometry-based palmitoyl-proteomics of breast and prostate cancer cells ± ZDHHC3 ablation identified 22–28 antioxidant/redox-regulatory proteins as candidate ZDHHC3 substrates; ZDHHC3 ablation elevated oxidative stress, which synergized with chemotherapeutic agents to enhance anti-growth effects. Comparative mass spectrometry palmitoyl-proteomics, RNAi ablation, fluorescence dye oxidative stress assays, cell proliferation assays Cellular and molecular life sciences Medium 32986127
2021 A high-throughput Acyl-cLIP assay was developed and validated for ZDHHC3/7/20 enzymatic activity; in vitro results from this assay correlated with cell-based palmitoylation assays, confirming ZDHHC3 catalytic activity as amenable to quantitative screening. Acyl-cLIP (acylation-coupled lipophilic induction of polarization) high-throughput assay, cell-based palmitoylation assay ACS chemical biology Medium 34374518
2023 ZDHHC3 palmitoylates IRHOM2 at C476 within the iRhom homology domain via its DHHC (C157) catalytic domain; palmitoylation promotes IRHOM2 cytomembrane translocation and stabilization by blocking TRIM31-mediated ubiquitination and proteasomal degradation; hepatocyte-specific ZDHHC3 knockout suppresses IRHOM2 accumulation and attenuates NASH pathology in rodent and rabbit models. Co-immunoprecipitation, site-directed mutagenesis (C476 of IRHOM2, C157 of ZDHHC3), acyl-RAC palmitoylation assay, ubiquitination assay, hepatocyte-specific KO mice, in vivo NASH diet models Advanced science High 37544908
2024 ZDHHC3 inhibits PD-L1 lysosomal degradation by palmitoylating PD-L1; the natural compound benzosceptrin C (BC) inhibits ZDHHC3 enzymatic activity, causing PD-L1 to relocate from the membrane to the cytoplasm, preventing recycling endosome-mediated return to the membrane, and triggering lysosomal degradation of PD-L1. Palmitoylation assay, ZDHHC3 enzymatic inhibition assay, subcellular localization imaging, lysosomal inhibitor rescue, in vivo MC38 tumor model, T cell cytotoxicity assay Cell reports. Medicine High 38237597
2024 ZDHHC3 S-acylates SCAP at C264, antagonizing HACE1-mediated ubiquitination of SCAP and preventing its proteasomal degradation; SREBP2 transcriptionally upregulates ZDHHC3, forming a positive feedback loop that sustains cholesterol biosynthesis in HCC; depalmitoylase ABHD17A reverses this modification. Site-directed mutagenesis (SCAP C264), palmitoylation assay, ubiquitination assay, ChIP/transcription factor binding assay, CRISPR/siRNA knockdown, in vivo DEN/CCl4 HCC mouse model, ZDHHC3 small-molecule inhibitor Cell reports High 39522165
2024 ZDHHC3 palmitoylates Cadm4 at cysteine-347 (C347) to stabilize its plasma membrane localization in oligodendrocytes; genetic deletion of ZDHHC3 reduces Cadm4 palmitoylation, causes Cadm4 internalization and degradation, and leads to CNS myelination defects and impaired neuronal transmission/cognitive behavior phenocopying Cadm4-C347A knock-in mice. Site-directed mutagenesis (Cadm4 C347A knock-in), ZDHHC3 knockout mice, palmitoylation assay, subcellular fractionation, confocal imaging, electrophysiology, behavioral assays Signal transduction and targeted therapy High 39327467
2024 ZDHHC3 catalyzes palmitoylation of the PML/RARα oncofusion protein, which is required for its oncogenic transcriptional activity; ZDHHC3 knockdown or overexpression respectively suppresses or promotes APL cell proliferation and blocks differentiation, and ZDHHC3 inhibition arrests malignant progression including in drug-resistant APL. RNAi knockdown, overexpression, palmitoylation assay, gene expression profiling (proliferation/differentiation markers), in vivo APL mouse model Acta pharmacologica Sinica Medium 39227737
2025 ZDHHC3 palmitoylates PRRSV nucleocapsid (N) protein at cysteine 90, which prevents N protein interaction with Nsp9 and inhibits viral RNA synthesis; the depalmitoylase LYPLA1 reverses this modification, counteracting ZDHHC3 activity and thereby promoting PRRSV replication. Palmitoylation assay, site-directed mutagenesis (N protein C90), co-immunoprecipitation (Nsp9-N interaction), viral RNA synthesis assay, siRNA knockdown, LYPLA1 inhibitor ML348 Veterinary microbiology Medium 39787744
2026 ZDHHC3 (together with ZDHHC7) mediates S-acylation of the small GTPase ARL15 at three conserved N-terminal cysteine residues (Cys17, Cys22, Cys23); loss of S-acylation disrupts ARL15 membrane association; dual siRNA knockdown and CRISPR knockout of both ZDHHC3 and ZDHHC7 markedly reduces ARL15 S-acylation and redistributes ARL15 from membranes to cytosol. Acyl-PEGyl exchange gel-shift assay (APEGS), site-directed mutagenesis of ARL15 cysteines, siRNA knockdown, CRISPR/Cas9 gene disruption, confocal imaging, subcellular fractionation The Journal of biological chemistry Medium 41999893
2026 ZDHHC3 S-acylates CRY1 (the core circadian transcriptional repressor) at four cysteine residues; this S-acylation is required for CRY1 nuclear import and interaction with key clock components; loss of CRY1 S-acylation via cysteine mutagenesis or genetic deletion of DHHC3 impairs CRY1 repressor function and disrupts cellular circadian rhythms. Unbiased palmitoylation screen of clock proteins, site-directed mutagenesis of CRY1 cysteines, DHHC3 genetic deletion, nuclear import assay, co-immunoprecipitation of clock components, circadian rhythm bioluminescence reporter assay bioRxivpreprint Medium 42239456

Source papers

Stage 0 corpus · 32 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2004 The gamma2 subunit of GABA(A) receptors is a substrate for palmitoylation by GODZ. The Journal of neuroscience : the official journal of the Society for Neuroscience 203 15229235
2006 GODZ-mediated palmitoylation of GABA(A) receptors is required for normal assembly and function of GABAergic inhibitory synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience 138 17151279
2024 Benzosceptrin C induces lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting DHHC3. Cell reports. Medicine 71 38237597
2017 Protein Acyltransferase DHHC3 Regulates Breast Tumor Growth, Oxidative Stress, and Senescence. Cancer research 68 29055014
2022 ALKBH5 promotes PD-L1-mediated immune escape through m6A modification of ZDHHC3 in glioma. Cell death discovery 64 36566230
2012 Palmitoylation by DHHC3 is critical for the function, expression, and stability of integrin α6β4. Cellular and molecular life sciences : CMLS 50 22314500
2002 Isolation and characterization of Golgi apparatus-specific GODZ with the DHHC zinc finger domain. Biochemical and biophysical research communications 50 12163046
2015 The Cysteine-rich Domain of the DHHC3 Palmitoyltransferase Is Palmitoylated and Contains Tightly Bound Zinc. The Journal of biological chemistry 49 26487721
2016 ZDHHC3 Tyrosine Phosphorylation Regulates Neural Cell Adhesion Molecule Palmitoylation. Molecular and cellular biology 39 27247265
2016 Dissociation of Golgi-associated DHHC-type Zinc Finger Protein (GODZ)- and Sertoli Cell Gene with a Zinc Finger Domain-β (SERZ-β)-mediated Palmitoylation by Loss of Function Analyses in Knock-out Mice. The Journal of biological chemistry 38 27875292
2012 Regulation in the targeting of TRAIL receptor 1 to cell surface via GODZ for TRAIL sensitivity in tumor cells. Cell death and differentiation 31 22240897
2024 ZDHHC3-mediated SCAP S-acylation promotes cholesterol biosynthesis and tumor immune escape in hepatocellular carcinoma. Cell reports 29 39522165
2023 Palmitoyltransferase ZDHHC3 Aggravates Nonalcoholic Steatohepatitis by Targeting S-Palmitoylated IRHOM2. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 29 37544908
2021 High-Throughput Enzyme Assay for Screening Inhibitors of the ZDHHC3/7/20 Acyltransferases. ACS chemical biology 21 34374518
2018 The Absence of DHHC3 Affects Primary and Latent Herpes Simplex Virus 1 Infection. Journal of virology 21 29187538
2024 Treating ICB-resistant cancer by inhibiting PD-L1 via DHHC3 degradation induced by cell penetrating peptide-induced chimera conjugates. Cell death & disease 19 39349454
2017 Binding of Herpes Simplex Virus 1 UL20 to GODZ (DHHC3) Affects Its Palmitoylation and Is Essential for Infectivity and Proper Targeting and Localization of UL20 and Glycoprotein K. Journal of virology 19 28724772
2009 Golgi-specific DHHC zinc finger protein GODZ mediates membrane Ca2+ transport. The Journal of biological chemistry 19 19955568
2020 Antioxidant functions of DHHC3 suppress anti-cancer drug activities. Cellular and molecular life sciences : CMLS 18 32986127
2024 Palmitoylation regulates myelination by modulating the ZDHHC3-Cadm4 axis in the central nervous system. Signal transduction and targeted therapy 16 39327467
2024 Palmitoyltransferase ZDHHC3 is essential for the oncogenic activity of PML/RARα in acute promyelocytic leukemia. Acta pharmacologica Sinica 11 39227737
2024 zDHHC3-mediated S-palmitoylation of SLC9A2 regulates apoptosis in kidney clear cell carcinoma. Journal of cancer research and clinical oncology 8 38619631
2023 Changes in miR-134-3p expression and zDHHC3-AMPARs axis in association with aluminum neurotoxicity. Environmental science and pollution research international 8 37495815
2017 ZDHHC3 as a Risk and Mortality Marker for Breast Cancer in African American Women. Cancer informatics 6 29276372
2025 ZDHHC3-LYPLA1 regulates PRRSV-2 replication through reversible palmitoylation. Veterinary microbiology 5 39787744
2016 Involvement of Protein Acyltransferase ZDHHC3 in Maintaining Oocyte Meiotic Arrest in Xenopus laevis. Biology of reproduction 5 27512151
2022 Recent progress of palmitoyl transferase DHHC3 as a novel antitumor target. Future medicinal chemistry 4 35134300
2022 Antioxidant and Anticancer Functions of Protein Acyltransferase DHHC3. Antioxidants (Basel, Switzerland) 4 35624824
2022 Structural Exploration on Palmitoyltransferase DHHC3 from Homo sapiens. Polymers 3 35893977
2026 S-acylation and membrane localization of the small GTPase ARL15 are mediated by the Golgi S-acyltransferases ZDHHC7 and ZDHHC3. The Journal of biological chemistry 0 41999893
2026 DHHC3-dependent S-Acylation of CRY1 regulates its subcellular localization and repressor function in the circadian clock. bioRxiv : the preprint server for biology 0 42239456
2026 DHHC3 interferes with antitumor immunity in melanoma cells. Oncotarget 0 42258147

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