- Length
- 2146 aa
- Mass
- 241.6 kDa
- Annotated
- 2026-04-28
130 papers in source corpus
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
No mechanistic findings about YLPM1 in the available literature (corpus appears contaminated with off-target papers).
Mechanism profile
Synthesis pass · controlled-vocabulary classification · explore literature graph →
No controlled-vocabulary terms were assigned to this entry.
Source papers
Stage 0 corpus · 130 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 1995 | Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. | Nature | 3346 | 7596406 |
| 2006 | Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. | Cell | 2861 | 17081983 |
| 2005 | A human protein-protein interaction network: a resource for annotating the proteome. | Cell | 1704 | 16169070 |
| 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | Proceedings of the National Academy of Sciences of the United States of America | 1479 | 12477932 |
| 2010 | Network organization of the human autophagy system. | Nature | 1286 | 20562859 |
| 2009 | Defining the human deubiquitinating enzyme interaction landscape. | Cell | 1282 | 19615732 |
| 2004 | Large-scale characterization of HeLa cell nuclear phosphoproteins. | Proceedings of the National Academy of Sciences of the United States of America | 1159 | 15302935 |
| 2015 | The BioPlex Network: A Systematic Exploration of the Human Interactome. | Cell | 1118 | 26186194 |
| 2017 | Architecture of the human interactome defines protein communities and disease networks. | Nature | 1085 | 28514442 |
| 2015 | A human interactome in three quantitative dimensions organized by stoichiometries and abundances. | Cell | 1015 | 26496610 |
| 1992 | ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain. | Cell | 986 | 1423621 |
| 2012 | The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. | Molecular cell | 973 | 22681889 |
| 2018 | VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. | Cell discovery | 829 | 29507755 |
| 2003 | Complete sequencing and characterization of 21,243 full-length human cDNAs. | Nature genetics | 754 | 14702039 |
| 2004 | ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia. | The New England journal of medicine | 706 | 15329427 |
| 2021 | Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. | Cell | 705 | 33961781 |
| 2012 | A census of human soluble protein complexes. | Cell | 689 | 22939629 |
| 2011 | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Briefings in bioinformatics | 656 | 21873635 |
| 2018 | High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies. | Molecular cell | 580 | 29395067 |
| 1995 | Essential role for ZAP-70 in both positive and negative selection of thymocytes. | Nature | 455 | 7630421 |
| 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | Genome research | 438 | 15489334 |
| 2015 | A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. | Cell | 433 | 26638075 |
| 2022 | OpenCell: Endogenous tagging for the cartography of human cellular organization. | Science (New York, N.Y.) | 432 | 35271311 |
| 2010 | Systematic analysis of human protein complexes identifies chromosome segregation proteins. | Science (New York, N.Y.) | 421 | 20360068 |
| 1994 | Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase. | Science (New York, N.Y.) | 416 | 8202712 |
| 2002 | Inhibition of retroviral RNA production by ZAP, a CCCH-type zinc finger protein. | Science (New York, N.Y.) | 410 | 12215647 |
| 2005 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. | Genome research | 409 | 16344560 |
| 2015 | Panorama of ancient metazoan macromolecular complexes. | Nature | 407 | 26344197 |
| 1996 | Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling. | Science (New York, N.Y.) | 347 | 8638162 |
| 2021 | A proximity-dependent biotinylation map of a human cell. | Nature | 339 | 34079125 |
| 1995 | Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function. | The EMBO journal | 334 | 7781602 |
| 2010 | Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. | Cell | 318 | 21145461 |
| 1998 | Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice. | Molecular and cellular biology | 309 | 9671496 |
| 2010 | ZAP-70: an essential kinase in T-cell signaling. | Cold Spring Harbor perspectives in biology | 298 | 20452964 |
| 2016 | The cell proliferation antigen Ki-67 organises heterochromatin. | eLife | 265 | 26949251 |
| 2004 | Functional proteomics mapping of a human signaling pathway. | Genome research | 247 | 15231748 |
| 2008 | Relative value of ZAP-70, CD38, and immunoglobulin mutation status in predicting aggressive disease in chronic lymphocytic leukemia. | Blood | 245 | 18577710 |
| 2013 | The functional interactome landscape of the human histone deacetylase family. | Molecular systems biology | 235 | 23752268 |
| 2011 | Toward an understanding of the protein interaction network of the human liver. | Molecular systems biology | 207 | 21988832 |
| 2016 | EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis. | Cancer cell | 201 | 27505670 |
| 2007 | Structural basis for the inhibition of tyrosine kinase activity of ZAP-70. | Cell | 200 | 17512407 |
| 2017 | TRIM25 Enhances the Antiviral Action of Zinc-Finger Antiviral Protein (ZAP). | PLoS pathogens | 173 | 28060952 |
| 1995 | Activating and inhibitory mutations in adjacent tyrosines in the kinase domain of ZAP-70. | The Journal of biological chemistry | 171 | 7642520 |
| 2009 | The structure, regulation, and function of ZAP-70. | Immunological reviews | 163 | 19290920 |
| 2004 | Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2. | Immunity | 152 | 14738763 |
| 2014 | ZAP-70 genotype disrupts the relationship between microbiota and host, leading to spondyloarthritis and ileitis in SKG mice. | Arthritis & rheumatology (Hoboken, N.J.) | 150 | 25048686 |
| 1996 | Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases. | The Journal of biological chemistry | 145 | 8798454 |
| 2001 | Cbl promotes ubiquitination of the T cell receptor zeta through an adaptor function of Zap-70. | The Journal of biological chemistry | 135 | 11353765 |
| 2007 | CD38 and ZAP-70 are functionally linked and mark CLL cells with high migratory potential. | Blood | 129 | 17699742 |
| 1994 | The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav. | The Journal of biological chemistry | 126 | 7798261 |
| 2017 | ZAP-70 in Signaling, Biology, and Disease. | Annual review of immunology | 123 | 29237129 |
| 2015 | The Zinc-Finger Antiviral Protein ZAP Inhibits LINE and Alu Retrotransposition. | PLoS genetics | 122 | 25951186 |
| 1996 | Association of tyrosine protein kinase Zap-70 with the protooncogene product p120c-cbl in T lymphocytes. | The Journal of experimental medicine | 122 | 8551236 |
| 1996 | RANTES induces tyrosine kinase activity of stably complexed p125FAK and ZAP-70 in human T cells. | The Journal of experimental medicine | 121 | 9064347 |
| 1996 | Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function. | Molecular and cellular biology | 120 | 8756661 |
| 2007 | ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia. | Blood | 118 | 18048647 |
| 2003 | Unexpected requirement for ZAP-70 in pre-B cell development and allelic exclusion. | Immunity | 114 | 12705855 |
| 2019 | KHNYN is essential for the zinc finger antiviral protein (ZAP) to restrict HIV-1 containing clustered CpG dinucleotides. | eLife | 113 | 31284899 |
| 2015 | The Broad-Spectrum Antiviral Protein ZAP Restricts Human Retrotransposition. | PLoS genetics | 113 | 26001115 |
| 2012 | Translational repression precedes and is required for ZAP-mediated mRNA decay. | The EMBO journal | 112 | 23023399 |
| 1999 | TCR and CD28 are coupled via ZAP-70 to the activation of the Vav/Rac-1-/PAK-1/p38 MAPK signaling pathway. | Journal of immunology (Baltimore, Md. : 1950) | 108 | 10395678 |
| 2002 | In the immune synapse, ZAP-70 controls T cell polarization and recruitment of signaling proteins but not formation of the synaptic pattern. | Immunity | 107 | 12387734 |
| 2001 | Tyrosine phosphorylation-dependent activation of NF-kappa B. Requirement for p56 LCK and ZAP-70 protein tyrosine kinases. | European journal of biochemistry | 102 | 11231305 |
| 1998 | Differential requirements for ZAP-70 in TCR signaling and T cell development. | Journal of immunology (Baltimore, Md. : 1950) | 100 | 9794398 |
| 2012 | Structure of N-terminal domain of ZAP indicates how a zinc-finger protein recognizes complex RNA. | Nature structural & molecular biology | 95 | 22407013 |
| 2013 | Structural basis for activation of ZAP-70 by phosphorylation of the SH2-kinase linker. | Molecular and cellular biology | 90 | 23530057 |
| 2002 | Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases. | Nature immunology | 90 | 11836527 |
| 2007 | HIV-1 Nef assembles a Src family kinase-ZAP-70/Syk-PI3K cascade to downregulate cell-surface MHC-I. | Cell host & microbe | 87 | 18005690 |
| 2019 | Characterization of Novel Splice Variants of Zinc Finger Antiviral Protein (ZAP). | Journal of virology | 86 | 31118263 |
| 1995 | Reconstitution of Syk function by the ZAP-70 protein tyrosine kinase. | Immunity | 84 | 7538440 |
| 2002 | Tyrosine phosphorylation of VHR phosphatase by ZAP-70. | Nature immunology | 82 | 12447358 |
| 2002 | Signaling through ZAP-70 is required for CXCL12-mediated T-cell transendothelial migration. | Blood | 81 | 11964272 |
| 1998 | ZAP-70-dependent and -independent activation of Erk in Jurkat T cells. Differences in signaling induced by H2o2 and Cd3 cross-linking. | The Journal of biological chemistry | 78 | 9553143 |
| 1996 | Enhancement of lymphocyte responsiveness by a gain-of-function mutation of ZAP-70. | Molecular and cellular biology | 78 | 8943331 |
| 1999 | Perturbed regulation of ZAP-70 and sustained tyrosine phosphorylation of LAT and SLP-76 in c-Cbl-deficient thymocytes. | Journal of immunology (Baltimore, Md. : 1950) | 77 | 10358158 |
| 2021 | The short isoform of the host antiviral protein ZAP acts as an inhibitor of SARS-CoV-2 programmed ribosomal frameshifting. | Nature communications | 75 | 34893599 |
| 2018 | From APOBEC to ZAP: Diverse mechanisms used by cellular restriction factors to inhibit virus infections. | Biochimica et biophysica acta. Molecular cell research | 70 | 30290238 |
| 1999 | Dephosphorylation of ZAP-70 and inhibition of T cell activation by activated SHP1. | European journal of immunology | 69 | 10458769 |
| 2008 | ZAP-mediated mRNA degradation. | RNA biology | 67 | 18418085 |
| 2007 | Distinct roles for Syk and ZAP-70 during early thymocyte development. | The Journal of experimental medicine | 67 | 17606633 |
| 2005 | ZAP-70 methylation status is associated with ZAP-70 expression status in chronic lymphocytic leukemia. | Haematologica | 67 | 16079107 |
| 2020 | CpG Dinucleotides Inhibit HIV-1 Replication through Zinc Finger Antiviral Protein (ZAP)-Dependent and -Independent Mechanisms. | Journal of virology | 66 | 31748389 |
| 2005 | Immunohistochemical analysis of ZAP-70 expression in B-cell lymphoid neoplasms. | The Journal of pathology | 60 | 15685592 |
| 2006 | ZAP-70 is expressed by normal and malignant human B-cell subsets of different maturational stage. | Leukemia | 54 | 16482211 |
| 1998 | ZAP-70 tyrosine kinase is required for LFA-1-dependent T cell migration. | The Journal of cell biology | 54 | 9732296 |
| 1998 | ZAP-70 association with T cell receptor zeta (TCRzeta): fluorescence imaging of dynamic changes upon cellular stimulation. | The Journal of cell biology | 53 | 9813084 |
| 2006 | B lymphocytes in humans express ZAP-70 when activated in vivo. | European journal of immunology | 52 | 16482508 |
| 2014 | Validation of ZAP-70 methylation and its relative significance in predicting outcome in chronic lymphocytic leukemia. | Blood | 51 | 24868078 |
| 2020 | Immunomodulatory drugs activate NK cells via both Zap-70 and cereblon-dependent pathways. | Leukemia | 50 | 32238854 |
| 2019 | ZAP's stress granule localization is correlated with its antiviral activity and induced by virus replication. | PLoS pathogens | 45 | 31116799 |
| 2000 | Defective recruitment and activation of ZAP-70 in common variable immunodeficiency patients with T cell defects. | European journal of immunology | 44 | 11009097 |
| 1997 | ZAP-70 tyrosine kinase is required for the up-regulation of Fas ligand in activation-induced T cell apoptosis. | Journal of immunology (Baltimore, Md. : 1950) | 42 | 9233606 |
| 2020 | Human cytomegalovirus evades ZAP detection by suppressing CpG dinucleotides in the major immediate early 1 gene. | PLoS pathogens | 41 | 32886716 |
| 2022 | Poly(ADP-ribose) potentiates ZAP antiviral activity. | PLoS pathogens | 40 | 35130321 |
| 2008 | A novel ZAP-70 dependent FRET based biosensor reveals kinase activity at both the immunological synapse and the antisynapse. | PloS one | 38 | 18231606 |
| 1997 | Regulation of ZAP-70 intracellular localization: visualization with the green fluorescent protein. | The Journal of experimental medicine | 38 | 9362531 |
| 2021 | S-farnesylation is essential for antiviral activity of the long ZAP isoform against RNA viruses with diverse replication strategies. | PLoS pathogens | 37 | 34695163 |
| 2020 | Zinc-finger antiviral protein (ZAP) is a restriction factor for replication of modified vaccinia virus Ankara (MVA) in human cells. | PLoS pathogens | 37 | 32866210 |
| 2020 | Clinical, Immunological, and Genetic Features in 49 Patients With ZAP-70 Deficiency: A Systematic Review. | Frontiers in immunology | 36 | 32431715 |
| 1998 | T cell activation induced by novel gain-of-function mutants of Syk and ZAP-70. | The Journal of biological chemistry | 36 | 9624129 |
| 2022 | TRIM25 and ZAP target the Ebola virus ribonucleoprotein complex to mediate interferon-induced restriction. | PLoS pathogens | 35 | 35533151 |
| 2017 | The 3C protease of enterovirus A71 counteracts the activity of host zinc-finger antiviral protein (ZAP). | The Journal of general virology | 35 | 29182509 |
| 2005 | In vivo correction of ZAP-70 immunodeficiency by intrathymic gene transfer. | The Journal of clinical investigation | 35 | 16075064 |
| 2000 | Recent advances in the design and synthesis of SH2 inhibitors of Src, Grb2 and ZAP-70. | Current medicinal chemistry | 35 | 10911019 |
| 2011 | Disruption of HLA-DR raft, deregulations of Lck-ZAP-70-Cbl-b cross-talk and miR181a towards T cell hyporesponsiveness in leprosy. | Molecular immunology | 33 | 21453975 |
| 2020 | Porcine reproductive and respiratory syndrome virus Nsp4 cleaves ZAP to antagonize its antiviral activity. | Veterinary microbiology | 31 | 33035816 |
| 2006 | ZAP-70 mRNA quantification in B-cell chronic lymphocytic leukaemia. | European journal of haematology | 29 | 16519700 |
| 2002 | TCR/CD3 down-modulation and zeta degradation are regulated by ZAP-70. | Journal of immunology (Baltimore, Md. : 1950) | 29 | 12165490 |
| 1999 | Interdomain B in ZAP-70 regulates but is not required for ZAP-70 signaling function in lymphocytes. | Molecular and cellular biology | 29 | 9858619 |
| 1994 | Immunodeficiency diseases. Multiple roles for ZAP-70. | Current biology : CB | 29 | 7953563 |
| 2019 | HTLV-1 contains a high CG dinucleotide content and is susceptible to the host antiviral protein ZAP. | Retrovirology | 28 | 31842935 |
| 2012 | ZAP inhibits murine gammaherpesvirus 68 ORF64 expression and is antagonized by RTA. | Journal of virology | 28 | 23255809 |
| 2000 | A peptide library approach identifies a specific inhibitor for the ZAP-70 protein tyrosine kinase. | Molecular cell | 27 | 11090635 |
| 2018 | Intensity and duration of TCR signaling is limited by p38 phosphorylation of ZAP-70T293 and destabilization of the signalosome. | Proceedings of the National Academy of Sciences of the United States of America | 26 | 29440413 |
| 2004 | ZAP is a CRM1-dependent nucleocytoplasmic shuttling protein. | Biochemical and biophysical research communications | 26 | 15358138 |
| 2004 | ZAP-70 expression in B-cell hematologic malignancy is not limited to CLL/SLL. | American journal of clinical pathology | 26 | 15487457 |
| 2020 | ZAP-70 Shapes the Immune Microenvironment in B Cell Malignancies. | Frontiers in oncology | 25 | 33194762 |
| 2015 | Nuclear matrix protein Matrin 3 is a regulator of ZAP-mediated retroviral restriction. | Retrovirology | 25 | 26129669 |
| 2004 | T-cell receptor-induced phosphorylation of the zeta chain is efficiently promoted by ZAP-70 but not Syk. | Blood | 25 | 15059847 |
| 2015 | Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding. | The Biochemical journal | 24 | 25287889 |
| 2014 | Characterisation of chicken ZAP. | Developmental and comparative immunology | 24 | 24877657 |
| 2005 | ZAP-70 in B cell malignancies. | Leukemia & lymphoma | 24 | 16263570 |
| 1996 | Mechanism of activation for Zap-70 catalytic activity. | Proceedings of the National Academy of Sciences of the United States of America | 24 | 8901551 |
| 2022 | The Role of ZAP and TRIM25 RNA Binding in Restricting Viral Translation. | Frontiers in cellular and infection microbiology | 23 | 35800389 |
| 2015 | Integration of innate into adaptive immune responses in ZAP-70-positive chronic lymphocytic leukemia. | Blood | 23 | 26508782 |
| 1997 | A dual participation of ZAP-70 and scr protein tyrosine kinases is required for TCR-induced tyrosine phosphorylation of Sam68 in Jurkat T cells. | European journal of immunology | 23 | 9464824 |
| 2007 | Analogous regulatory sites within the alphaC-beta4 loop regions of ZAP-70 tyrosine kinase and AGC kinases. | Biochimica et biophysica acta | 21 | 17977811 |
| 2006 | Clinical implications of ZAP-70 expressionin chronic lymphocytic leukemia. | Cytometry. Part B, Clinical cytometry | 21 | 16906580 |
| 2005 | Distribution and ZAP-70 expression of WHO lymphoma categories in Shanxi, China: a review of 447 cases using a tissue microarray technique. | Applied immunohistochemistry & molecular morphology : AIMM | 21 | 16280661 |
| 2021 | T cell receptor-dependent S-acylation of ZAP-70 controls activation of T cells. | The Journal of biological chemistry | 20 | 33482200 |