Affinage

YEATS4

YEATS domain-containing protein 4 · UniProt O95619

Length
227 aa
Mass
26.5 kDa
Annotated
2026-06-11
56 papers in source corpus 28 papers cited in narrative 28 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

YEATS4/GAS41 is a histone acylation reader that couples recognition of acetylated and crotonylated histone marks to deposition of the histone variant H2A.Z and to transcriptional activation of target genes (PMID:29437725, PMID:29900004). Its YEATS domain engages H3K27ac and H3K14ac through an aromatic cage (PMID:29437725, PMID:29145630), with H3K14ac recognition additionally requiring a distinct pocket that reads the histone H3 N-terminus through the essential residue E109 (PMID:37844223), and the full-length protein dimerizes via a C-terminal coiled-coil to bind diacetylated H3 with enhanced bivalent affinity (PMID:30071723); the YEATS domain also reads H3K14 crotonylation (PMID:41060805). Through these reading activities GAS41 is recruited to promoters of actively transcribed genes, where it recruits the Tip60/p400 and SRCAP chromatin-remodeling complexes to deposit and acetylate H2A.Z (PMID:29900004, PMID:19966225), and the conserved yeast ortholog Yaf9 functions as a subunit of both the NuA4 acetyltransferase and SWR1/SWR1-C remodeling complexes that perform these reactions (PMID:12917332, PMID:19966225, PMID:40768570). GAS41 acts as a transcriptional co-activator more broadly, bridging the H3K27ac mark to sequence-specific and general transcription machinery: it anchors NRF2 at the SLC7A11 promoter to activate transcription and repress ferroptosis (PMID:38514704), recruits the Dot1l–RNA Pol II complex to drive Lmo4 transcription during lymphoid lineage commitment (PMID:31434684), and recruits BRD2 and Mediator to activate genes controlling nuclear shape (PMID:38964523). Independently of its chromatin-remodeling role, GAS41 represses the p53 pathway, occupying p21 and p14ARF promoters in unstressed cells and forming a complex with the phosphatase PP2Cβ that dephosphorylates p53 at Ser366 (PMID:16705155, PMID:21317290). GAS41 is essential for RNA transcription and cell viability (PMID:11901157), and is itself stabilized when KAT8-mediated acetylation blocks its HUWE1-dependent ubiquitination (PMID:38526153).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 2000 Medium

    Early work asked what cellular structures GAS41 associates with, revealing a nuclear protein that binds the spindle-organizing protein NuMA and hinting at roles beyond transcription.

    Evidence Yeast two-hybrid, surface plasmon resonance, and GFP/immunofluorescence localization

    PMID:10913114

    Open questions at the time
    • Functional consequence of the NuMA interaction not established
    • No chromatin or transcriptional mechanism defined at this stage
  2. 2002 Medium

    Genetic ablation established that GAS41 is essential, defining a baseline requirement for the protein in RNA transcription and cell survival.

    Evidence Conditional gene targeting in chicken DT40 cells with RNA synthesis measurement

    PMID:11901157

    Open questions at the time
    • The transcriptional pathway through which depletion stops RNA synthesis was not defined
    • Did not identify the direct molecular partners mediating essentiality
  3. 2003 High

    Identification of the yeast ortholog Yaf9 as a NuA4 subunit placed the protein within a histone acetyltransferase complex and linked it to chromatin-based stress resistance.

    Evidence Reciprocal co-IP with NuA4 subunits and genetic epistasis with esa1/yng2 plus benomyl sensitivity assays

    PMID:12917332

    Open questions at the time
    • Did not establish the molecular basis of Yaf9's contribution to NuA4
    • Connection to H2A.Z not yet made
  4. 2006 High

    Two studies separated GAS41's transcriptional roles, showing it is a co-activator for AP-2β and, independently of TIP60, a repressor of the p53 pathway via promoter occupancy.

    Evidence Co-IP, GST pull-down, EMSA and reporter assays for AP-2β; siRNA, coiled-coil mutagenesis, ChIP and p53 phosphorylation assays for p53 repression

    PMID:16698963 PMID:16705155

    Open questions at the time
    • The mechanism by which GAS41 represses p21/p14ARF promoters was not molecularly defined
    • How GAS41 dissociation from promoters is triggered by stress was unresolved
  5. 2009 High

    Structure of the Yaf9 YEATS domain and its histone-binding activity provided the first mechanistic link between the protein and H2A.Z chromatin deposition.

    Evidence X-ray crystallography, in vitro H3/H4 binding, mutagenesis and H2A.Z ChIP in yeast

    PMID:19966225

    Open questions at the time
    • Specific acetyl-mark recognized by the domain not yet defined
    • Did not establish the reader chemistry later attributed to the aromatic cage
  6. 2011 High

    Reconstitution showed GAS41 confers substrate specificity to PP2Cβ, explaining mechanistically how it suppresses p53 by enabling dephosphorylation at Ser366.

    Evidence Co-IP and in vitro phosphatase assays with mutant p53 substrates plus UV-survival assays

    PMID:21317290

    Open questions at the time
    • Whether the GAS41-PP2Cβ axis operates at chromatin or in the nucleoplasm was not resolved
    • Relationship to GAS41 promoter occupancy at p53 targets not integrated
  7. 2018 High

    A cluster of structural studies defined GAS41/Yaf9 as an aromatic-cage reader of H3K27ac and H3K14ac, mechanistically explaining its recruitment to active promoters and its role in H2A.Z deposition via Tip60/p400, SRCAP and SWR1.

    Evidence Crystal structures of YEATS domains with acetyl-H3 peptides, aromatic-cage mutagenesis, ITC, ChIP-seq and knockdown/rescue in NSCLC, mouse ESCs and yeast

    PMID:29145630 PMID:29437725 PMID:29900004 PMID:30071723

    Open questions at the time
    • The basis for H3K14ac recognition was incomplete until the H3NT pocket was defined
    • How reader binding is coordinated with remodeler enzymatic activity not resolved
  8. 2019 Medium

    In vivo conditional knockout showed GAS41 reads H3K27ac to recruit Dot1l-RNA Pol II for developmental gene activation, extending its co-activator function to lymphoid lineage commitment.

    Evidence Conditional knockout mouse, ChIP co-occupancy and co-IP at the Lmo4 promoter with rescue

    PMID:31434684

    Open questions at the time
    • Generality of Dot1l-Pol II recruitment beyond Lmo4 not established
    • Single-lab in vivo model
  9. 2023 High

    Identification of an H3NT-binding pocket and the essential residue E109 completed the structural logic of how GAS41 recognizes H3K14ac to occupy H2A.Z-enriched promoters.

    Evidence X-ray crystallography, NMR, binding assays, E109 mutagenesis and ChIP for GAS41/H2A.Z

    PMID:37844223

    Open questions at the time
    • Whether the H3NT pocket contributes to non-H2A.Z transcriptional functions not tested
  10. 2024 High

    Multiple studies broadened GAS41's reader output to disease-relevant programs and revealed its own regulation, anchoring NRF2 to repress ferroptosis, controlling nuclear-shape gene transcription via BRD2/Mediator, and being stabilized by KAT8 acetylation against HUWE1 degradation.

    Evidence CRISPR screens, reciprocal co-IP, ChIP, ferroptosis and tumor models; CRISPR KO with YEATS-mutant rescue and ChIP for BRD2/Mediator; protein-stability screen and ubiquitination assays

    PMID:38514704 PMID:38526153 PMID:38964523

    Open questions at the time
    • How GAS41 selects between distinct partner complexes at different loci is unknown
    • Whether NRF2 anchoring and H2A.Z deposition are mechanistically coupled is unresolved
  11. 2025 High

    Single-molecule and biochemical work extended the reader repertoire to H3K14 crotonylation and defined kinetically how Yaf9 governs SWR1 residence on chromatin.

    Evidence Crotonyl-binding assays with multi-omics in breast cancer cells; live-cell single-molecule tracking and ChIP-exo in yeast

    PMID:40768570 PMID:41060805

    Open questions at the time
    • Whether crotonylation reading uses the same aromatic cage as acetylation is not delineated
    • Quantitative kinetics of human GAS41 on chromatin not measured
  12. 2026 Medium

    Genetic dissection showed Yaf9 is required in both NuA4 and SWR1 for viability under impaired H4 acetylation, and that this essential role is separable from its YEATS acyl-reading activity.

    Evidence Synthetic lethality, cell-cycle analysis, recombination-pathway assessment with a YEATS-inactivating mutant

    PMID:41653028

    Open questions at the time
    • The reading-independent molecular function of Yaf9 within the complexes is undefined
    • Whether the human ortholog has an equivalent reading-independent essential role is untested

Open questions

Synthesis pass · forward-looking unresolved questions
  • How GAS41 chooses among its many partner complexes (Tip60/p400, SRCAP, NRF2, Dot1l-Pol II, BRD2/Mediator, PP2Cβ) at specific loci, and how its acyl-reading and reading-independent functions are integrated, remains unresolved.
  • No unified model for context-specific partner selection
  • Coupling between reader binding and downstream enzymatic/remodeling activity undefined
  • Mechanism distinguishing acetyl- from crotonyl-mark output unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0042393 histone binding 6 GO:0140110 transcription regulator activity 5 GO:0060090 molecular adaptor activity 3 GO:0098772 molecular function regulator activity 1
Localization
GO:0005694 chromosome 3 GO:0005634 nucleus 1
Pathway
R-HSA-4839726 Chromatin organization 5 R-HSA-1852241 Organelle biogenesis and maintenance 4 R-HSA-74160 Gene expression (Transcription) 4
Partners
BRD2DOT1LHUWE1KAT8NRF2NUMAPP2CΒTFIIF
Complex memberships
GAS41-PP2CβNuA4SWR1/SRCAPTip60/p400

Evidence

Reading pass · 28 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2018 GAS41 YEATS domain reads histone H3 acetylation (H3K27ac and H3K14ac) via an aromatic cage mechanism, and this interaction recruits GAS41 to promoters of actively transcribed genes to promote H2A.Z deposition in NSCLC cells; disruption of the YEATS-acetylhistone interaction impairs H2A.Z chromatin association and suppresses cancer cell growth. Crystal structure of YEATS domain bound to acetylated H3 peptides, ChIP-seq, siRNA knockdown, in vitro and in vivo proliferation assays Genes & development High 29437725
2018 Gas41 YEATS domain binds H3K27ac and H3K14ac and recruits Tip60/p400 and SRCAP complexes to deposit H2A.Z into bivalent chromatin domains in mouse ESCs; knockdown of Gas41 reduces H2A.Z and H3K27me3 levels on bivalent domains and disrupts ESC colony morphology, which is rescued by wild-type but not YEATS-mutant Gas41. Crystal structure of YEATS domain with H3K27ac peptide, Co-IP, ChIP-seq, mutagenesis, ESC knockdown/rescue experiments Cell discovery High 29900004
2003 Yaf9 (yeast ortholog) is a subunit of the NuA4 histone acetyltransferase complex; yaf9Δ mutants are hypersensitive to microtubule-depolymerizing agents and synthetically lethal with mitotic apparatus mutants, linking NuA4-mediated H4 acetylation to spindle stress resistance. Co-immunoprecipitation with NuA4 subunits, genetic epistasis with esa1 and yng2 mutants, microtubule depolymerization assays, benomyl sensitivity assays Molecular and cellular biology High 12917332
2009 The Yaf9 YEATS domain adopts an Ig-fold beta-sandwich structure similar to histone chaperone Asf1; it binds histones H3 and H4 in vitro, and structure-function analysis shows the YEATS domain is required for H2A.Z chromatin deposition at specific promoters and for H2A.Z acetylation in yeast. X-ray crystallography (2.3 Å), in vitro histone binding assays, structure-function mutagenesis, ChIP for H2A.Z occupancy Proceedings of the National Academy of Sciences of the United States of America High 19966225
2006 GAS41 is required for repression of the p53 tumor suppressor pathway during normal proliferation; siRNA-mediated knockdown or disruption of the C-terminal coiled-coil motif activates p53, induces p53-Ser15 phosphorylation, and activates p21 transcription. GAS41 is pre-bound to p21 and p14ARF promoters in unstressed cells and dissociates upon stress. This repression is TIP60-independent, as a coiled-coil mutant of GAS41 retains normal TIP60 complex assembly and HAT activity. siRNA knockdown, promoter-targeted mutagenesis, reporter gene assays, ChIP, Western blot for p53 phosphorylation Molecular and cellular biology High 16705155
2011 GAS41 forms a complex with PP2Cβ; this GAS41-PP2Cβ complex (not PP2Cβ alone) specifically dephosphorylates p53 at serine 366, and ectopic expression of both proteins reduces UV-induced p53 up-regulation and increases cell survival after genotoxic damage. GAS41 acts as a regulatory subunit that confers substrate specificity to PP2Cβ. Co-immunoprecipitation, in vitro phosphatase assay with mutant p53 substrates, ectopic overexpression, UV damage survival assay The Journal of biological chemistry High 21317290
2018 Yaf9 YEATS domain preferentially recognizes H3K27ac; crystal structure reveals K27ac side chain inserts between two aromatic residues, and mutation of these aromatic residues abolishes interaction in vitro and in vivo, causing loss of SWR1-dependent H2A.Z incorporation equivalent to YAF9 deletion. Crystal structure of YEATS domain with H3K27ac peptide, ITC/fluorescence binding assays, aromatic cage mutagenesis, ChIP for H2A.Z Nucleic acids research High 29145630
2018 Full-length dimeric GAS41 (via its C-terminal coiled-coil dimerization domain) binds diacetylated H3 peptides with enhanced affinity compared to monoacetylated peptides through a bivalent binding mode; crystal structure of the YEATS domain with H3K23acK27ac was determined to reveal the molecular basis. Crystal structure, ITC binding assays comparing mono- and diacetylated peptides, biochemical characterization of full-length vs. domain constructs ACS chemical biology High 30071723
2023 GAS41 YEATS domain recognition of H3K14ac requires the N-terminus of histone H3 (H3NT); a unique pocket in GAS41 YEATS (away from the aromatic cage) binds H3NT, and E109 of GAS41 is essential for this pocket and for GAS41/H2A.Z chromatin occupancy at H2A.Z-enriched promoters. X-ray crystallography, NMR, biochemical binding assays, mutagenesis of E109, ChIP for H2A.Z and GAS41 Proceedings of the National Academy of Sciences of the United States of America High 37844223
2024 GAS41 interacts with NRF2 and is recruited to the SLC7A11 promoter by recognizing H3K27ac; GAS41 anchors NRF2 on chromatin at SLC7A11 promoter to activate transcription and repress ferroptosis. GAS41 binding to H3K27ac occurs independently of NRF2, and GAS41 bridges NRF2 to the H3K27ac mark. Genome-wide CRISPR-Cas9 screen, Co-IP of GAS41-NRF2, ChIP for GAS41 and NRF2 at SLC7A11 promoter, ferroptosis assays, in vivo tumor models Nature communications High 38514704
2002 GAS41 interacts with the AF10 leucine zipper domain and with INI1 (SNF5 homolog, a SWI/SNF complex component), placing GAS41 in connection with ATP-dependent chromatin remodeling; AF10 immunoprecipitate also contains INI1. Yeast two-hybrid screening, co-immunoprecipitation in vivo Blood Medium 11756182
2000 GAS41 binds to the C-terminal rod region of NuMA in vitro with a Kd of ~2×10⁻⁷ M; GAS41 localizes to the nucleus in interphase and shows uniform distribution in mitotic cells. Yeast two-hybrid, dot overlay assay, surface plasmon resonance, GFP-GAS41 fluorescence microscopy, immunofluorescence The Journal of biological chemistry Medium 10913114
2002 Targeted disruption of GAS41 in chicken DT40 cells is lethal; tetracycline-regulated depletion of GAS41 leads to rapid decrease in RNA synthesis followed by cell death, indicating GAS41 is required for RNA transcription. Gene targeting by homologous recombination, conditional knockdown with tetracycline-regulated promoter, RNA synthesis assay The Journal of biological chemistry Medium 11901157
2006 GAS41 interacts with transcription factor AP-2β through C-terminal domains of both proteins; GAS41 stimulates AP-2β transcriptional activity and enhances AP-2β DNA-binding activity, functioning as a transcriptional co-activator. Yeast two-hybrid, co-immunoprecipitation, GST pull-down, co-localization by immunofluorescence, reporter gene assay, EMSA Nucleic acids research Medium 16698963
2010 GAS41 binds both subunits of general transcription factor TFIIF (RAP30 and RAP74) in vitro and in vivo; GAS41 binds two non-overlapping regions of the RAP30 C-terminus with an ionic component; GAS41 does not directly bind TBP or RNA Pol II, suggesting it functions as a TFIIF co-factor. GST pull-down, co-immunoprecipitation of endogenous proteins, domain mapping BMC molecular biology Medium 20618998
2019 Yeats4 recruits the Dot1l-RNA Pol II complex to the Lmo4 promoter by recognizing H3K27ac modification, initiating Lmo4 transcription in α4β7+ CLPs; Yeats4 conditional knockout in the hematopoietic system reduces ILC numbers and impairs ILC lineage commitment from common lymphoid progenitors. Conditional knockout mouse model, ChIP demonstrating Yeats4 and Dot1l co-occupancy at Lmo4 promoter, co-IP of Yeats4-Dot1l-RNA Pol II, rescue experiments The Journal of experimental medicine Medium 31434684
2024 KAT8-mediated acetylation of YEATS4 prevents its ubiquitination and proteasomal degradation by the E3 ligase HUWE1; acetylation of YEATS4 by KAT8 impairs YEATS4-HUWE1 interaction, stabilizing YEATS4 protein levels. Protein Stability Regulators Screening Assay, co-IP of YEATS4-HUWE1, KAT8 inhibitor MG149 treatment, ubiquitination assays, CRISPR-Cas9 library screening Advanced science Medium 38526153
2021 Yaf9 reads histone acetylation during the oxidative phase of the yeast metabolic cycle to recruit SWR1-C and NuA4 complexes, promoting H2A.Z deposition and H4 acetylation at metabolic gene promoters; disruption of Yaf9-H3 acetyl reading impairs timely transcription of metabolic genes and reduces chromatin machinery occupancy. ChIP-seq, ChIP-qPCR, genome-wide transcriptomics, YEATS domain point mutants blocking acetylhistone binding Genes & development Medium 34819351
2004 Bdf1p is a multicopy suppressor of yaf9Δ phenotypes in yeast; both Yaf9p and Bdf1p bind to promoters of underexpressed genes and H3/H4 acetylation at these promoters is significantly reduced in yaf9Δ, indicating Yaf9p promotes histone acetylation at target gene promoters. Multicopy suppressor screen, genome-wide transcript analysis, ChIP for Yaf9p/Bdf1p promoter occupancy and histone acetylation Molecular microbiology Medium 15255905
2022 GAS41 binds to H2A.Z.2 and activates Notch1 and its downstream mediators; depletion of GAS41 or H2A.Z.2 down-regulates Notch signaling and sensitizes pancreatic cancer cells to gemcitabine. Co-immunoprecipitation, ChIP, siRNA knockdown, in vitro and in vivo tumorigenesis assays Cellular oncology Medium 35503594
2011 Gas41 directly interacts with c-Myc and n-Myc proteins; the C-terminal portion of Gas41 (outside the YEATS domain) is required for this interaction; Gas41 and Myc show correlated expression in neuroblastomas and glioblastomas. Yeast two-hybrid, GST pull-down, domain mapping with YEATS and C-terminal deletion constructs, yeast complementation assay Acta biochimica Polonica Low 22068108
2012 GAS41 overexpression leads to increased multipolar spindles and is associated with pericentrosome material; combined overexpression with reduced NuMA increases bipolar spindles with misaligned chromosomes, suggesting GAS41 plays a role at the spindle pole. Induced and endogenous overexpression in HeLa cells, immunofluorescence microscopy for spindle morphology, co-manipulation with NuMA Genes, chromosomes & cancer Low 22619067
2002 TACC1 interacts with the C-terminus of GAS41/NuBI1, suggesting GAS41 participates in multiple protein complexes potentially relevant to oncogenesis. Yeast two-hybrid screening of mammary epithelial cDNA library The Biochemical journal Low 11903063
2017 YEATS4 interacts with β-catenin and activates β-catenin/TCF signaling; knockdown of YEATS4 impairs oncogenic Ras-mediated malignant transformation of normal pancreatic cells. Co-immunoprecipitation of YEATS4-β-catenin, luciferase reporter for TCF activity, siRNA knockdown, transformation assay with oncogenic Ras Oncotarget Low 28445953
2025 YEATS4 is a reader of H3K14 crotonylation (H3K14cr); H3K14cr reading by YEATS4 is associated with transcriptional activation of fatty acid metabolism genes (CD36, CPT1A, ACOX1) and enhancement of breast cancer stem cell self-renewal. Binding assays for H3K14cr, integrative metabolomic/epigenomic/transcriptomic analysis, ChIP-seq, knockdown/overexpression in breast cancer cells Cell reports Medium 41060805
2024 GAS41 regulates nuclear shape by binding H3K27ac/cr through its YEATS domain; YEATS domain mutants unable to bind H3K27ac/cr fail to rescue nuclear shape abnormalities in GAS41-knockout cells. GAS41 recruits BRD2 and the Mediator complex (MED14, MED23) to gene loci of nuclear shape regulators (LMNB1, LMNB2, SYNE4, LEMD2) to activate their transcription. Genetic ablation (CRISPR), rescue with wild-type vs. YEATS domain mutant GAS41, ChIP for BRD2/Mediator subunits at target loci, nuclear morphology imaging Pharmacological research Medium 38964523
2025 Yaf9-YEATS domain slows SWR1 complex dissociation from chromatin (while Bdf1 promotes association); live-cell single-molecule tracking and genome-wide ChIP-exo reveal Yaf9 and Bdf1 contributions to global SWR1 targeting and histone exchange at +1 nucleosomes. Live-cell single-molecule tracking, genome-wide ChIP combined with exonuclease treatment (ChIP-exo), domain mutant analysis Science advances High 40768570
2026 Yaf9 is required in both NuA4 and SWR1 complexes (not just one) for cell viability when H4 acetylation is impaired; loss of Yaf9 in a strain with impaired H4 acetylation causes G2/M arrest and activation of homologous recombination. This synthetic lethality is independent of Yaf9 YEATS domain acyl-lysine reading activity. Genetic epistasis (synthetic lethality), cell cycle analysis, assessment of homologous recombination pathway activation, YEATS domain inactivation mutant Genetics Medium 41653028

Source papers

Stage 0 corpus · 56 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2018 Recognition of histone acetylation by the GAS41 YEATS domain promotes H2A.Z deposition in non-small cell lung cancer. Genes & development 109 29437725
2003 Yaf9, a novel NuA4 histone acetyltransferase subunit, is required for the cellular response to spindle stress in yeast. Molecular and cellular biology 94 12917332
2002 The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SWI/SNF complex. Blood 76 11756182
2006 GAS41 is required for repression of the p53 tumor suppressor pathway during normal cellular proliferation. Molecular and cellular biology 70 16705155
2018 Gas41 links histone acetylation to H2A.Z deposition and maintenance of embryonic stem cell identity. Cell discovery 64 29900004
2009 Asf1-like structure of the conserved Yaf9 YEATS domain and role in H2A.Z deposition and acetylation. Proceedings of the National Academy of Sciences of the United States of America 57 19966225
2013 YEATS4 is a novel oncogene amplified in non-small cell lung cancer that regulates the p53 pathway. Cancer research 48 24170126
2018 Yaf9 subunit of the NuA4 and SWR1 complexes targets histone H3K27ac through its YEATS domain. Nucleic acids research 45 29145630
2018 GAS41 Recognizes Diacetylated Histone H3 through a Bivalent Binding Mode. ACS chemical biology 40 30071723
2002 Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells. The Biochemical journal 40 11903063
2006 GAS41 interacts with transcription factor AP-2beta and stimulates AP-2beta-mediated transactivation. Nucleic acids research 39 16698963
2000 GAS41, a highly conserved protein in eukaryotic nuclei, binds to NuMA. The Journal of biological chemistry 38 10913114
2012 Association of chromosome 12 locus with antihypertensive response to hydrochlorothiazide may involve differential YEATS4 expression. The pharmacogenomics journal 37 22350108
2016 Downregulation of YEATS4 by miR-218 sensitizes colorectal cancer cells to L-OHP-induced cell apoptosis by inhibiting cytoprotective autophagy. Oncology reports 32 27779719
2024 GAS41 modulates ferroptosis by anchoring NRF2 on chromatin. Nature communications 31 38514704
2011 The GAS41-PP2Cbeta complex dephosphorylates p53 at serine 366 and regulates its stability. The Journal of biological chemistry 29 21317290
2002 Targeted disruption of the GAS41 gene encoding a putative transcription factor indicates that GAS41 is essential for cell viability. The Journal of biological chemistry 27 11901157
2001 Expression, cellular distribution and protein binding of the glioma amplified sequence (GAS41), a highly conserved putative transcription factor. Oncogene 27 11521196
2021 Development of potent dimeric inhibitors of GAS41 YEATS domain. Cell chemical biology 22 34289376
2018 Overexpression of YEATS4 contributes to malignant outcomes in gastric carcinoma. American journal of cancer research 22 30662802
2015 Knockdown of YEATS4 inhibits colorectal cancer cell proliferation and induces apoptosis. American journal of translational research 21 26045900
2016 Regulation of Cell Proliferation and Migration by miR-203 via GAS41/miR-10b Axis in Human Glioblastoma Cells. PloS one 20 27467502
2015 Transcriptome analysis indicates TFEB1 and YEATS4 as regulatory transcription factors for drug resistance of ovarian cancer. Oncotarget 18 26307679
2024 Targeting the KAT8/YEATS4 Axis Represses Tumor Growth and Increases Cisplatin Sensitivity in Bladder Cancer. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 17 38526153
2022 GAS41 mediates proliferation and GEM chemoresistance via H2A.Z.2 and Notch1 in pancreatic cancer. Cellular oncology (Dordrecht, Netherlands) 17 35503594
2017 YEATS4 promotes the tumorigenesis of pancreatic cancer by activating beta-catenin/TCF signaling. Oncotarget 17 28445953
2022 Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4. Journal of medicinal chemistry 16 36562986
2019 Yeats4 drives ILC lineage commitment via activation of Lmo4 transcription. The Journal of experimental medicine 16 31434684
2023 GAS41 promotes H2A.Z deposition through recognition of the N terminus of histone H3 by the YEATS domain. Proceedings of the National Academy of Sciences of the United States of America 14 37844223
2004 The bromodomain-containing protein Bdf1p acts as a phenotypic and transcriptional multicopy suppressor of YAF9 deletion in yeast. Molecular microbiology 13 15255905
2010 The YEATS family member GAS41 interacts with the general transcription factor TFIIF. BMC molecular biology 12 20618999
2021 Recognition of acetylated histone by Yaf9 regulates metabolic cycling of transcription initiation and chromatin regulatory factors. Genes & development 10 34819351
2008 Role of Hog1 and Yaf9 in the transcriptional response of Saccharomyces cerevisiae to cesium chloride. Physiological genomics 10 18198280
2021 Multi-Institutional Implementation of Clinical Decision Support for APOL1, NAT2, and YEATS4 Genotyping in Antihypertensive Management. Journal of personalized medicine 9 34071920
2012 GAS41 amplification results in overexpression of a new spindle pole protein. Genes, chromosomes & cancer 9 22619067
2009 Cesium chloride sensing and signaling in Saccharomyces cerevisiae: an interplay among the HOG and CWI MAPK pathways and the transcription factor Yaf9. FEMS yeast research 9 19220477
2023 Mechanistic insights into genomic structure and functions of a novel oncogene YEATS4. Frontiers in cell and developmental biology 8 37435030
2011 Direct interaction of Gas41 and Myc encoded by amplified genes in nervous system tumours. Acta biochimica Polonica 8 22068108
2023 Unveiling the role of GAS41 in cancer progression. Cancer cell international 7 37853482
2024 YEATS domain-containing protein GAS41 regulates nuclear shape by working in concert with BRD2 and the mediator complex in colorectal cancer. Pharmacological research 6 38964523
2014 Drosophila oncogene Gas41 is an RNA interference modulator that intersects heterochromatin and the small interfering RNA pathway. The FEBS journal 6 25323651
2004 The glioma-amplified sequence 41 gene (GAS41) is a direct Myb target gene. Nucleic acids research 6 15356292
2010 Sp1 and Sp3 regulate transcription of the chicken GAS41 gene. Biochimica et biophysica acta 5 20153453
2025 GAS41 promotes ITGA4-mediated PI3K/Akt/mTOR signaling pathway and glioma tumorigenesis. Biochemical pharmacology 3 39788387
2024 The C-terminal protein interaction domain of the chromatin reader Yaf9 is critical for pathogenesis of Candida albicans. mSphere 3 38376217
2007 The chromatin structure of the lysozyme GAS41 origin of DNA replication changes during the cell cycle. Biological research 3 18064355
2025 Single-cell and spatial atlas of glioblastoma heterogeneity: characterizing the PCLAF+ subtype and YEATS4's oncogenic role. Frontiers in immunology 2 40787449
2025 YEATS4 reads histone crotonylation to promote fatty acid metabolism and cancer cell stemness. Cell reports 2 41060805
2011 In vivo binding of Orc2 to a region of the chicken lysozyme GAS41 origin containing multiple Sp1-binding sites. DNA and cell biology 2 21879882
2025 Strawberry notch 1 safeguards neuronal genome via regulation of Yeats4 expression. Cell death discovery 1 40707437
2025 A human YEATS4 variant confers resistance to TST and IGRA conversion despite Mycobacterium tuberculosis exposure. Genome medicine 1 41094526
2025 Discovery and Development of a Small-Molecule Inhibitor Targeting the GAS41 YEATS Domain in Nonsmall Cell Lung Cancer. Journal of medicinal chemistry 1 41294372
2026 Yaf9 connects NuA4 and SWR1 functions to maintain genome integrity. Genetics 0 41653028
2026 Sinonasal low-grade non-intestinal type adenocarcinomas with clear cell features: Clinicopathological and molecular analysis of 6 cases highlighting molecular heterogeneity and identification of a novel ETV6::YEATS4 fusion. Virchows Archiv : an international journal of pathology 0 42191886
2025 Histone acetylation readers Bdf1 and Yaf9 direct SWR1 remodeler to +1 nucleosome. Science advances 0 40768570
2025 High YEATS4 expression characterizes MDM2-amplified liposarcoma. Cancer genetics 0 40840014

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