Affinage

WIPF2

WAS/WASL-interacting protein family member 2 · UniProt Q8TF74

Length
440 aa
Mass
46.3 kDa
Annotated
2026-04-28
100 papers in source corpus 8 papers cited in narrative 8 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

WIPF2 (also known as WICH or WIRE) is a verprolin-family actin-regulatory scaffold that coordinates actin cytoskeletal remodeling through both WASP/N-WASP-dependent and -independent mechanisms. It binds N-WASP and WASP via a C-terminal W region to cooperatively drive actin microspike formation, while its direct actin filament cross-linking activity—negatively regulated by N-WASP association—produces bundled actin fibers (PMID:11829459, PMID:15707985). Independent of N-WASP, WIPF2 promotes filopodia formation through a Cdc42-regulated interaction with IRSp53, and it inhibits PDGF-β receptor endocytosis in a WASP-binding-dependent manner (PMID:20678498, PMID:15265696). In cancer cells WIPF2 is non-redundant with WIP and specifically controls invadopodium maturation and matrix degradation through N-WASP activation, while in airway epithelial cells it mediates phagocytic internalization of fungal conidia (PMID:27009365, PMID:30792969).

Mechanistic history

Synthesis pass · year-by-year structured walk · 7 steps
  1. 2002 High

    Identification of WIPF2 as an N-WASP/WASP-binding protein established the gene as a new verprolin-family scaffold linking receptor signaling to actin polymerization machinery.

    Evidence Co-immunoprecipitation, dominant-negative fragment expression, and ectopic expression in mammalian cells showing cooperative microspike formation; parallel study demonstrating WIRE–Nckβ binding and PDGF-induced actin protrusions

    PMID:11829459 PMID:12213210

    Open questions at the time
    • Direct actin-binding activity of WIPF2 not yet demonstrated
    • Minimal binding domain on WIPF2 not mapped
    • Physiological signaling contexts beyond PDGF not explored
  2. 2004 High

    Mutagenesis of the WASP-binding domain revealed that WIPF2 possesses a WASP-independent actin reorganization function and a separable WASP-dependent function in inhibiting PDGF-β receptor endocytosis, establishing functional modularity.

    Evidence Site-directed mutagenesis of residues 408–412 and adjacent aromatic residues combined with receptor endocytosis and actin morphology assays

    PMID:15265696

    Open questions at the time
    • Mechanism by which WIPF2 inhibits receptor endocytosis is unclear
    • Identity of actin-regulatory partners in the WASP-independent pathway unknown
  3. 2005 High

    In vitro reconstitution demonstrated that WIPF2 directly cross-links actin filaments into straight bundles, and N-WASP association suppresses this activity, revealing a reciprocal regulatory relationship between WIPF2 and N-WASP.

    Evidence In vitro co-sedimentation, fluorescence and electron microscopy of reconstituted actin, and overexpression in fibroblasts

    PMID:15707985

    Open questions at the time
    • Domains mediating actin cross-linking not mapped
    • Physiological contexts in which bundling versus microspike formation are selected remain undefined
    • No structural model for the WIPF2–actin filament interaction
  4. 2010 High

    Discovery of the WIPF2–IRSp53 interaction, regulated by Cdc42, established an N-WASP-independent pathway for filopodia formation and provided a mechanism for plasma membrane targeting of the complex.

    Evidence Yeast two-hybrid, pull-down, and co-expression in N-WASP−/− mouse fibroblasts with constitutively active Cdc42

    PMID:20678498

    Open questions at the time
    • Whether the IRSp53 pathway operates in vivo or in specific tissue contexts is untested
    • Relationship between actin cross-linking activity and filopodia induction through IRSp53 not clarified
  5. 2016 High

    Functional separation from WIP demonstrated that WIPF2 specifically controls invadopodium maturation and ECM degradation—not assembly—through N-WASP activation, assigning non-redundant roles to verprolin-family members in cancer cell invasion.

    Evidence RNAi knockdown, super-resolution imaging, invadopodium degradation assay, and co-immunoprecipitation in breast cancer cells

    PMID:27009365

    Open questions at the time
    • Mechanism by which WIPF2 selectively promotes maturation rather than assembly is unresolved
    • In vivo relevance for metastasis not established
  6. 2019 High

    WIPF2 was shown to mediate phagocytic internalization of fungal conidia in airway epithelial cells, extending its function to innate immune defense at mucosal surfaces.

    Evidence RNAi knockdown reducing conidial internalization and super-resolution localization of WIPF2 at sites of bound conidia in human bronchial epithelial cells

    PMID:30792969

    Open questions at the time
    • Whether Arp2/3 and/or N-WASP are required downstream of WIPF2 in this context is not resolved
    • Role in in vivo pulmonary defense not tested
  7. 2020 Medium

    WIPF2 was validated as a direct miR-186-5p target in oxidized-LDL-treated cells, linking WIPF2 expression levels to proliferation and apoptosis regulation in an atherosclerosis model.

    Evidence Luciferase reporter, RNA immunoprecipitation, RNA pull-down, and siRNA knockdown phenocopying miRNA overexpression in ox-LDL-treated cell lines

    PMID:32735135

    Open questions at the time
    • Single-lab finding not independently confirmed
    • Downstream mechanism connecting WIPF2 to proliferation/apoptosis regulation is not defined
    • Relevance to atherosclerosis in vivo is untested

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the structural basis of WIPF2-mediated actin cross-linking, how cells switch between WIPF2's bundling, microspike, and filopodia functions, and the in vivo physiological consequences of WIPF2 loss.
  • No knockout or conditional KO phenotype reported in any organism
  • No structural model for WIPF2 alone or in complex with actin or N-WASP
  • Regulation of WIPF2 by post-translational modifications largely unexplored

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0008092 cytoskeletal protein binding 4 GO:0060090 molecular adaptor activity 3
Localization
GO:0005856 cytoskeleton 2 GO:0005886 plasma membrane 2
Pathway
R-HSA-162582 Signal Transduction 3 R-HSA-168256 Immune System 1
Partners
BAIAP2CDC42NCK2WASWASL

Evidence

Reading pass · 8 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2002 WIPF2 (WICH/WIRE) associates strongly with N-WASP (and weakly with WASP) via its C-terminal WASP-interacting (W) region, and ectopic expression of WICH induces actin-microspike formation cooperatively with N-WASP; expression of the W fragment suppresses N-WASP-induced microspike formation, demonstrating an essential role for WICH in N-WASP-induced actin microspike formation. Co-immunoprecipitation, ectopic expression, dominant-negative fragment expression, actin morphology assay Biochemical and biophysical research communications High 11829459
2002 WIPF2 (WIRE) binds the WH1 domain of WASP and N-WASP, localizes to actin filaments, and in cells co-expressing WIRE and WASP, relocates WASP to actin filaments in a direct-interaction-dependent manner; WIRE also binds the PDGF receptor substrate Nckβ, and PDGF treatment of WIRE-expressing cells induces peripheral filopodia/lamellipodia-like protrusions and WASP translocation to the cell margin, linking WIRE to PDGF receptor signaling and actin polymerization machinery. Co-immunoprecipitation, ectopic expression, fluorescence microscopy, growth-factor stimulation assay Experimental cell research High 12213210
2004 The WASP-binding domain of WIPF2 (WIRE) was mapped to a core motif at amino acid residues 408–412 plus an adjacent stretch of aromatic residues; substitutions in either motif abolished WASP binding. WIRE mutants unable to bind WASP still reorganized the actin filament system, indicating a WASP-independent actin regulatory pathway. Intact WASP-binding was required for WIRE-induced inhibition of PDGF-β receptor endocytosis, revealing two mechanistically distinct functions of WIRE. Site-directed mutagenesis, co-immunoprecipitation, receptor endocytosis assay, actin morphology assay Experimental cell research High 15265696
2005 WIPF2 (WICH) cross-links actin filaments in vitro, producing straight bundled filaments as visualized by fluorescence and electron microscopy; overexpression in fibroblasts causes thick actin fiber formation. Direct association with N-WASP suppresses this cross-linking activity, establishing N-WASP as a negative regulator of WICH-mediated actin bundling. In vitro co-sedimentation assay, fluorescence microscopy, electron microscopy, overexpression in cultured fibroblasts Biochemical and biophysical research communications High 15707985
2010 WIPF2 (WIRE) interacts with IRSp53 via its Verprolin (V)-domain, and co-expression of WIRE and IRSp53 in N-WASP-null mouse fibroblasts induces filopodia; this is independent of N-WASP. Cdc42 regulates the WIRE–IRSp53 interaction and the plasma membrane localization of the complex, and active Cdc42(G12V) with WIRE–IRSp53 markedly increases filopodia number. Yeast two-hybrid screen, pull-down assay, co-expression in N-WASP-/- fibroblasts, fluorescence microscopy, dominant-negative/active mutants Experimental cell research High 20678498
2016 In human breast cancer cells, WIPF2 (WICH/WIRE) plays a non-redundant role with WIP in invadopodium biology: WIP is essential for invadopodium assembly, whereas WIPF2 regulates N-WASP activation to control invadopodium maturation and degradative activity. Nck interaction with WIPF2 and WIP modulates invadopodium maturation, and changes in their levels alter Nck distribution. RNAi knockdown, biochemical fractionation, advanced fluorescence (super-resolution) imaging, invadopodium degradation assay, co-immunoprecipitation Scientific reports High 27009365
2019 WIPF2 mediates phagocytosis/internalization of Aspergillus fumigatus conidia into human bronchial airway epithelial cells; RNAi-mediated knockdown of WIPF2 significantly reduces conidial internalization, and super-resolution fluorescence microscopy shows WIPF2 is transiently localized to the site of bound conidia during internalization. RNAi knockdown, cell internalization assay, super-resolution fluorescence microscopy Frontiers in cellular and infection microbiology High 30792969
2020 In atherosclerosis cell lines, WIPF2 is a direct target of miR-186-5p; knockdown of WIPF2 phenocopies miR-186-5p overexpression in inhibiting cell proliferation and promoting apoptosis in ox-LDL-induced AS cells. Luciferase reporter, RNA immunoprecipitation, and RNA pull-down assays confirm WIPF2 3'UTR as a direct miR-186-5p target. Luciferase reporter assay, RNA immunoprecipitation, RNA pull-down, Western blot, flow cytometry, siRNA knockdown Human & experimental toxicology Medium 32735135

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1998 DNA-templated assembly and electrode attachment of a conducting silver wire. Nature 870 9486645
2014 A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome. Nature structural & molecular biology 187 25132179
1995 A new DNA nanostructure, the G-wire, imaged by scanning probe microscopy. Nucleic acids research 162 7899091
2013 Transposable elements re-wire and fine-tune the transcriptome. PLoS genetics 153 23358118
2004 A molecular switch and proton wire synchronize the active sites in thiamine enzymes. Science (New York, N.Y.) 150 15514159
2020 The Crystal Structure of a Biological Insulated Transmembrane Molecular Wire. Cell 136 32289252
2007 A novel electroporation method using a capillary and wire-type electrode. Biosensors & bioelectronics 112 18242073
2014 Novel graphene/carbon nanotube composite fibers for efficient wire-shaped miniature energy devices. Advanced materials (Deerfield Beach, Fla.) 92 24464762
2008 Self-assembled DNA photonic wire for long-range energy transfer. Journal of the American Chemical Society 90 18975869
2015 Architecture and migration of an epithelium on a cylindrical wire. Proceedings of the National Academy of Sciences of the United States of America 84 25922533
2020 Walking the tight wire between cell adhesion and WNT signalling: a balancing act for β-catenin. Open biology 81 33292105
2007 Artificial G-wire switch with 2,2'-bipyridine units responsive to divalent metal ions. Journal of the American Chemical Society 78 17439212
1992 Signal and noise in modulation transfer function determinations using the slit, wire, and edge techniques. Medical physics 78 1518465
2023 Miniscope-LFOV: A large-field-of-view, single-cell-resolution, miniature microscope for wired and wire-free imaging of neural dynamics in freely behaving animals. Science advances 75 37083539
1997 DNA: Insulator or wire? Chemistry & biology 69 9070421
2013 A novel mouse model of aortic valve stenosis induced by direct wire injury. Arteriosclerosis, thrombosis, and vascular biology 67 24311378
2013 Gene regulation: Long RNAs wire up cancer growth. Nature 60 23945584
2002 WICH, a novel verprolin homology domain-containing protein that functions cooperatively with N-WASP in actin-microspike formation. Biochemical and biophysical research communications 56 11829459
2017 Directional Photonic Wire Mediated by Homo-Förster Resonance Energy Transfer on a DNA Origami Platform. ACS nano 51 29063765
2003 Collagenase plaque digestion for facilitating guide wire crossing in chronic total occlusions. Circulation 47 12939226
2022 Mimicry of the proton wire mechanism of enzymes inside a supramolecular capsule enables β-selective O-glycosylations. Nature chemistry 45 35798949
2011 The chromatin remodelling complex B-WICH changes the chromatin structure and recruits histone acetyl-transferases to active rRNA genes. PloS one 45 21559432
2007 Wire-based ureteral stents: impact on tensile strength and compression. Urology 45 18158013
2022 Production of cultured meat by culturing porcine smooth muscle cells in vitro with food grade peanut wire-drawing protein scaffold. Food research international (Ottawa, Ont.) 41 35940781
2013 DNA as a molecular wire: distance and sequence dependence. Analytical chemistry 40 23964773
2019 Luseogliflozin attenuates neointimal hyperplasia after wire injury in high-fat diet-fed mice via inhibition of perivascular adipose tissue remodeling. Cardiovascular diabetology 38 31672147
2016 Paper-based maskless enzymatic sensor for glucose determination combining ink and wire electrodes. Biosensors & bioelectronics 36 27856164
2016 Genes on a Wire: The Nucleoid-Associated Protein HU Insulates Transcription Units in Escherichia coli. Scientific reports 35 27545593
2013 Stress eating and tuning out: cancer cells re-wire metabolism to counter stress. Critical reviews in biochemistry and molecular biology 35 24099138
2002 The WASP-binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet-derived growth factor receptor. Experimental cell research 35 12213210
2020 Mobility connects: transposable elements wire new transcriptional networks by transferring transcription factor binding motifs. Biochemical Society transactions 34 32573687
2016 Proton Wire Dynamics in the Green Fluorescent Protein. Journal of chemical theory and computation 33 28068768
2010 Computational study on the interaction of N1 substituted pyrazole derivatives with B-raf kinase: an unusual water wire hydrogen-bond network and novel interactions at the entrance of the active site. Journal of chemical information and modeling 32 20524689
2009 Soluble Flt-1 gene transfer ameliorates neointima formation after wire injury in flt-1 tyrosine kinase-deficient mice. Arteriosclerosis, thrombosis, and vascular biology 32 19164801
2007 Cytotoxicity of orthodontic wire corroded in fluoride solution in vitro. The Angle orthodontist 32 17319773
2007 Kinetics of switchable proton escape from a proton-wire within green fluorescence protein. The journal of physical chemistry. B 31 17569555
2016 Kirschner wire pin site infection in hand and wrist fractures: incidence rate and risk factors. The Journal of hand surgery, European volume 30 27464583
1982 Treatment of carcinoma of the penis by iridium 192 wire implant. International journal of radiation oncology, biology, physics 30 7118622
2011 Mesenteric artery contraction and relaxation studies using automated wire myography. Journal of visualized experiments : JoVE 29 21969063
2005 Manufacture of porous polymer nerve conduits through a lyophilizing and wire-heating process. Journal of biomedical materials research. Part B, Applied biomaterials 28 15909301
2004 Homologous recombination: down to the wire. Current biology : CB 28 15296782
2024 CD4+ T cells re-wire granuloma cellularity and regulatory networks to promote immunomodulation following Mtb reinfection. Immunity 27 39214090
2019 A Novel DNA Helical Wire Containing HgII -Mediated T:T and T:G Pairs. Angewandte Chemie (International ed. in English) 27 31507027
2023 Superhydrophobic and Conductive Wire Membrane for Enhanced CO2 Electroreduction to Multicarbon Products. Angewandte Chemie (International ed. in English) 26 36849633
2012 Nano RNA aptamer wire for analysis of vitamin B₁₂. Analytical biochemistry 26 22658959
2010 A waferscale Si wire solar cell using radial and bulk p-n junctions. Nanotechnology 26 20935359
2013 Oxidative thymine mutation in DNA: water-wire-mediated proton-coupled electron transfer. Journal of the American Chemical Society 25 23421474
2012 Occipitocervical fusion using a contoured rod and wire construct in children: a reappraisal of a vintage technique. Journal of neurosurgery. Pediatrics 24 23157394
2011 Effect of garlic on bacterial biofilm formation on orthodontic wire. The Angle orthodontist 24 21446865
2008 A Potential Energy Function for Heterogeneous Proton-Wires. Ground and Photoactive States of the Proton-Wire in the Green Fluorescent Protein. Journal of chemical theory and computation 24 26636367
2022 4-Octyl itaconate suppresses the osteogenic response in aortic valvular interstitial cells via the Nrf2 pathway and alleviates aortic stenosis in mice with direct wire injury. Free radical biology & medicine 23 35787451
2020 Super-Soft DNA/Dopamine-Grafted-Dextran Hydrogel as Dynamic Wire for Electric Circuits Switched by a Microbial Metabolism Process. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 23 32670769
2016 WIP and WICH/WIRE co-ordinately control invadopodium formation and maturation in human breast cancer cell invasion. Scientific reports 22 27009365
2013 Endogenous CGRP protects against neointimal hyperplasia following wire-induced vascular injury. Journal of molecular and cellular cardiology 22 23416515
2010 Quantifying signal changes in nano-wire based biosensors. Nanoscale 22 21173975
2005 Life on the wire: on tensegrity and force balance in cells. Acta bio-medica : Atenei Parmensis 22 16116819
2004 The mammalian verprolin homologue WIRE participates in receptor-mediated endocytosis and regulation of the actin filament system by distinct mechanisms. Experimental cell research 22 15265696
2003 M-DNA: a self-assembling molecular wire for nanoelectronics and biosensing. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 22 12558018
2018 Effects of wire-type and mesh-type anode current collectors on performance and electrochemistry of microbial fuel cells. Chemosphere 21 29945047
2016 Biodegradable magnesium wire promotes regeneration of compressed sciatic nerves. Neural regeneration research 20 28197200
2005 WICH, a member of WASP-interacting protein family, cross-links actin filaments. Biochemical and biophysical research communications 20 15707985
2003 In vitro study of guide wire entrapment in currently available inferior vena cava filters. Journal of vascular and interventional radiology : JVIR 20 12847198
2023 Tripping the wire: sensing of viral protease activity by CARD8 and NLRP1 inflammasomes. Current opinion in immunology 19 37311351
2015 The B-WICH chromatin-remodelling complex regulates RNA polymerase III transcription by promoting Max-dependent c-Myc binding. Nucleic acids research 19 25883140
2014 A proton wire and water channel revealed in the crystal structure of isatin hydrolase. The Journal of biological chemistry 19 24917679
2014 High-wire act: the poised genome and cellular memory. The FEBS journal 19 25440020
2017 Catch and Release: rare cell analysis from a functionalised medical wire. Scientific reports 17 28233867
2000 Potentiometric detection of carboxylic acids, phosphate esters, and nucleotides in liquid chromatography using anion-selective coated-wire electrodes. Analytical chemistry 17 10815961
1998 Initial evaluation of a 290-microm diameter subcutaneous glucose sensor: glucose monitoring with a biocompatible, flexible-wire, enzyme-based amperometric microsensor in diabetic and nondiabetic humans. Journal of diabetes and its complications 17 9877461
2020 A Proton Wire Mediates Proton Coupled Electron Transfer from Hydroxyurea and Other Hydroxamic Acids to Tyrosyl Radical in Class Ia Ribonucleotide Reductase. The journal of physical chemistry. B 16 31904962
2011 Predicting and rationalizing the effect of surface charge distribution and orientation on nano-wire based FET bio-sensors. Nanoscale 15 21811738
2003 Ilizarov wire tensioning and holding methods: a biomechanical study. Injury 15 12565024
2022 MXene Enhanced Photoactivity of Bi2O3/Bi2S3 Heterojunction with G-wire Superstructure for Photoelectrochemical Detection of TET1 Protein. ACS sensors 14 36205635
2021 Spatial Separation of Plasmonic Hot-Electron Generation and a Hydrodehalogenation Reaction Center Using a DNA Wire. ACS nano 14 34875168
2019 Phagocytosis of Aspergillus fumigatus by Human Bronchial Epithelial Cells Is Mediated by the Arp2/3 Complex and WIPF2. Frontiers in cellular and infection microbiology 14 30792969
2018 Common cues wire the spinal cord: Axon guidance molecules in spinal neuron migration. Seminars in cell & developmental biology 14 29274387
2009 Measurement of orthodontic bracket tie wing elastic and plastic deformation by arch wire torque expression utilizing an optical image correlation technique. Journal of dental biomechanics 14 20948571
2008 Ultrafast Electronic and Vibrational Dynamics of Stabilized A State Mutants of the Green Fluorescent Protein (GFP): Snipping the Proton Wire. Chemical physics 14 19554079
2007 Auto-orientation of G-wire DNA on mica. Colloids and surfaces. B, Biointerfaces 14 17512706
2014 Excited-state proton coupled electron transfer between photolyase and the damaged DNA through water wire: a photo-repair mechanism. Physical chemistry chemical physics : PCCP 13 25341360
2021 A neutralizing IL-11 antibody reduces vessel hyperplasia in a mouse carotid artery wire injury model. Scientific reports 12 34667238
2021 Local delivery and controlled release of miR-34a loaded in hydroxyapatite/mesoporous organosilica nanoparticles composite-coated implant wire to accelerate bone fracture healing. Biomaterials 12 34920369
2016 The fabrication of well-interconnected polycaprolactone/hydroxyapatite composite scaffolds, enhancing the exposure of hydroxyapatite using the wire-network molding technique. Journal of biomedical materials research. Part B, Applied biomaterials 12 27504613
2021 A Single Molecule Polyphenylene-Vinylene Photonic Wire. ACS nano 11 33938214
2020 Endothelial cell distributions and migration under conditions of flow shear stress around a stent wire. Technology and health care : official journal of the European Society for Engineering and Medicine 11 31796716
2018 Collimated ultrabright gamma rays from electron wiggling along a petawatt laser-irradiated wire in the QED regime. Proceedings of the National Academy of Sciences of the United States of America 11 30224456
2010 Involvement of prostaglandins and histamine in nickel wire-induced acute inflammation in mice. Journal of biomedical materials research. Part A 11 19839048
2010 The mammalian verprolin, WIRE induces filopodia independent of N-WASP through IRSp53. Experimental cell research 11 20678498
2021 The WIRE study a phase II, multi-arm, multi-centre, non-randomised window-of-opportunity clinical trial platform using a Bayesian adaptive design for proof-of-mechanism of novel treatment strategies in operable renal cell cancer - a study protocol. BMC cancer 10 34794412
2019 Performance comparison of III-V//Si and III-V//InGaAs multi-junction solar cells fabricated by the combination of mechanical stacking and wire bonding. Scientific reports 10 30867491
2016 Involvement of COX-2 in nickel elution from a wire implanted subcutaneously in mice. Toxicology 10 27452194
2013 Epigallocatechin-3-gallate is a potent phytochemical inhibitor of intimal hyperplasia in the wire-injured carotid artery. Journal of vascular surgery 10 23538007
2008 Functional and structural changes in the retina of wire-haired dachshunds with early-onset cone-rod dystrophy. Investigative ophthalmology & visual science 10 18326738
2008 Role of the angiotensin II type 2 receptor in arterial remodeling after wire injury in mice. Hypertension research : official journal of the Japanese Society of Hypertension 10 18716374
2005 Active shielding of cylindrical saddle-shaped coils: application to wire-wound RF coils for very low field NMR and MRI. Journal of magnetic resonance (San Diego, Calif. : 1997) 10 16099186
2024 The maize transcription factor CCT regulates drought tolerance by interacting with Fra a 1, E3 ligase WIPF2, and auxin response factor Aux/IAA8. Journal of experimental botany 9 37725963
2022 Silicon carbide catalytic ceramic membranes with nano-wire structure for enhanced anti-fouling performance. Water research 9 36240708
2021 The hot-wire concept: Towards a one-element thermal biosensor platform. Biosensors & bioelectronics 9 33609951
2020 Long noncoding RNA SNHG14 regulates ox-LDL-induced atherosclerosis cell proliferation and apoptosis by targeting miR-186-5p/WIPF2 axis. Human & experimental toxicology 9 32735135
2012 Super MI sensor: recent advances of amorphous wire and CMOS-IC magneto-impedance sensor. Journal of nanoscience and nanotechnology 9 23035502