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Showing RPS2 — US5 is a alias.

RPS2

Small ribosomal subunit protein uS5 · UniProt P15880

Length
293 aa
Mass
31.3 kDa
Annotated
2026-06-10
44 papers in source corpus 15 papers cited in narrative 16 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RPS2 (uS5) is a universally conserved small (40S) ribosomal subunit protein whose residues lining the mRNA entry channel govern translation initiation fidelity and start codon selection, with nonlethal substitutions reducing bulk initiation and increasing discrimination against poor initiation codons such as near-cognate UUG and suboptimal Kozak-context AUG (PMID:34791232); in bacteria, mutations in the loop 2 region of uS5 confer spectinomycin resistance and likewise perturb translational accuracy and ribosome assembly (PMID:27855073). Decoding selectivity is dynamically tuned by phosphorylation of Ser176 at the uS4-uS5 interface, where a Ypk2-dependent phospho-Ser176 forms a salt bridge with Arg57 of uS4 to strengthen the interface, opposed by a TORC1/Pkc1 pathway (PMID:38340338). Before joining the ribosome, nascent uS5 is captured co-translationally by a dedicated chaperone — Tsr4 in budding yeast and its ortholog PDCD2 (Zfrp8 in Drosophila) in metazoans — which engages a conserved N-terminal extension (a FxxGFG motif within a 30-residue region) to promote uS5 solubility and incorporation into 40S subunits (PMID:31182640, PMID:33245768, PMID:26807849, PMID:41933732). uS5 is also arginine-methylated by PRMT3 (Rmt1 in budding yeast), which is tethered to ribosomes through uS5 itself, while the zinc-finger protein ZNF277 competes with PRMT3 for binding to nascent uS5 (PMID:17439947, PMID:20035717, PMID:30530495). During biogenesis uS5 is required for A2 cleavage and nuclear export competence of pre-40S particles, and its own nuclear import depends on importin-β (Pse1) and a second N-terminal basic signal (PMID:18820293, PMID:37509163). Extraribosomal and disease-associated functions reported in the corpus include RACK1-mediated protection of RPS2 from ubiquitin-proteasomal degradation coupled to NF-κB signaling (PMID:40522528), covalent ligand binding at C222 that triggers nucleolar stress and ribosomal protein–MDM2–p53 activation (PMID:36873185), and binding of pre-let-7a-1 RNA to suppress let-7 maturation in prostate cancer (PMID:21148031).

Mechanistic history

Synthesis pass · year-by-year structured walk · 16 steps
  1. 2007 High

    Established that uS5/RPS2 is a physiological substrate of a specific arginine methyltransferase, defining a post-translational modification of the protein beyond its structural role.

    Evidence PRMT3-knockout mice with Western blot for methylarginine and ribosome co-fractionation

    PMID:17439947

    Open questions at the time
    • Functional consequence of rpS2 arginine methylation for translation not defined
    • Methylated residues not mapped
  2. 2008 High

    Defined uS5 as required for a discrete step of small-subunit maturation, showing it is needed for A2 cleavage and nuclear export of pre-40S particles rather than only the mature ribosome.

    Evidence Genetic depletion in S. pombe with pre-rRNA processing, pulse-chase and nucleolar retention assays

    PMID:18820293

    Open questions at the time
    • Molecular partners mediating export competence not identified
    • Direct role versus assembly checkpoint effect not separated
  3. 2009 Medium

    Showed that the same uS5 substrate is methylated by an organism-specific enzyme (Rmt1) in yeast lacking a PRMT3 homolog, indicating divergent enzyme usage on a conserved target.

    Evidence rmt1 deletion strains with biochemical detection of asymmetric dimethyl/monomethylarginine

    PMID:20035717

    Open questions at the time
    • Only partial modification observed
    • Biological role of yeast Rps2 methylation unresolved
  4. 2010 Medium

    Identified an extraribosomal RNA-binding function in which RPS2 binds pre-let-7a-1 and blocks its maturation, linking RPS2 to oncogenic miRNA regulation.

    Evidence EMSA, supershift, IP, knockdown/overexpression in prostate cancer cells and SCID tumor model

    PMID:21148031

    Open questions at the time
    • RNA-binding interface on RPS2 not mapped
    • Relationship to ribosomal pool of RPS2 unclear
  5. 2016 Medium

    Demonstrated a direct PDCD2-family (Zfrp8) interaction with RpS2 in metazoa and a role in late ribosome assembly and cytoplasmic mRNA localization.

    Evidence Co-IP and RNAi knockdown with RNA localization assays in Drosophila

    PMID:26807849

    Open questions at the time
    • Co-translational nature not established in this work
    • Interaction interface unmapped
  6. 2017 High

    Localized translational-accuracy and assembly determinants to the loop 2 region of bacterial uS5, connecting this region to antibiotic resistance and rRNA processing.

    Evidence Systematic site-directed mutagenesis in E. coli with spectinomycin and fidelity reporters

    PMID:27855073

    Open questions at the time
    • Direct structural basis of fidelity effects not resolved
    • Generalizability to eukaryotic uS5 inferred only
  7. 2018 High

    Revealed a competition for nascent uS5 between PRMT3 and the zinc-finger protein ZNF277, defining an extraribosomal regulatory hub on uS5.

    Evidence AP-MS, reciprocal Co-IP, proximity ligation and competition experiments in human cells

    PMID:30530495

    Open questions at the time
    • Functional outcome of ZNF277 binding for ribosome biogenesis unclear
    • Hierarchy with PDCD2 binding not established
  8. 2019 High

    Identified Tsr4 as a dedicated cytoplasmic chaperone that engages nascent Rps2 via its N-terminal extension, explaining how uS5 is kept soluble before assembly.

    Evidence Co-translational Co-IP, genetic depletion and fractionation in S. cerevisiae

    PMID:31182640

    Open questions at the time
    • Handoff from chaperone to pre-40S not defined
    • Structural basis of N-terminal recognition not solved here
  9. 2020 High

    Established human PDCD2 as the functional Tsr4 ortholog, a co-translational uS5 chaperone whose loss phenocopies uS5 deficiency.

    Evidence AP-MS, co-translational Co-IP, PDCD2 knockdown with ribosome biogenesis and polysome readouts

    PMID:33245768

    Open questions at the time
    • Precise binding motif not yet mapped at this stage
    • Coordination with nuclear import factors unresolved
  10. 2022 High

    Connected uS5 mRNA-entry-channel residues to start codon recognition, showing they tune initiation fidelity in concert with eIF1/eIF1A.

    Evidence Rps2 mutagenesis with UUG and Kozak-context initiation reporters and epistasis in yeast

    PMID:34791232

    Open questions at the time
    • Structural mechanism at the entry channel not directly visualized
    • Whether effect is direct or via mRNA path geometry unresolved
  11. 2022 Medium

    Identified a covalent ligandable cysteine (C222) on RPS2 whose modification triggers nucleolar stress and p53 activation, defining a druggable extraribosomal stress node.

    Evidence Thiol-reactivity chemical proteomics and covalent binding/p53 assays in NPM1-mutant AML cells

    PMID:36873185

    Open questions at the time
    • Selectivity of heliangin for RPS2 versus other targets not fully excluded
    • Mechanism linking C222 modification to rRNA disruption unclear
  12. 2023 Medium

    Defined the nuclear import logic of uS5, identifying two independent import signals and the importin-β Pse1 as a carrier.

    Evidence GFP import reporters, deletion/point mutants and Co-IP with Pse1 in yeast

    PMID:37509163

    Open questions at the time
    • Relative in vivo contribution of the two pathways not quantified
    • Whether import is coupled to chaperone release unclear
  13. 2024 Medium

    Showed that phosphorylation of uS5 Ser176 at the uS4-uS5 interface dynamically regulates decoding selectivity through a salt bridge, with opposing kinase pathways setting accuracy.

    Evidence Ser176/Arg57 mutagenesis and kinase-mutant epistasis with fidelity reporters in yeast

    PMID:38340338

    Open questions at the time
    • Salt bridge not confirmed by direct structural evidence
    • Physiological signals tuning the phosphorylation balance unknown
  14. 2025 Medium

    Linked RPS2 stability to RACK1-dependent protection from proteasomal degradation and to NF-κB signaling, providing an extraribosomal regulatory and oncogenic axis.

    Evidence Co-IP, ubiquitination/MG132 assays, NF-κB reporter and rescue in glioma cells

    PMID:40522528

    Open questions at the time
    • E3 ligase for RPS2 not identified
    • Mechanism connecting RPS2 to NF-κB not defined
  15. 2026 Medium

    Mapped the uS5-PDCD2 interface to a 30-residue N-terminal region with a conserved FxxGFG motif and showed a peptide disruptor impairs cancer cell viability, defining a targetable chaperone interaction.

    Evidence Affinity purification, structural modeling, complementation biosensor, mutagenesis and viability assays in human cells

    PMID:41933732

    Open questions at the time
    • High-resolution structure of the complex not determined
    • Specificity of peptide effect versus general translation inhibition not fully resolved
  16. 2025 Low

    Placed RPS2 ubiquitination within an eIF2A-regulated ribosome-associated quality control pathway antagonizing USP10-dependent 40S rescue.

    Evidence TurboID proximity labeling MS, eIF2A knockout, SILAC and 40S footprinting (preprint)

    Open questions at the time
    • Preprint, single lab, mechanistic placement is indirect
    • E3 ligase and ubiquitination sites on RPS2 not defined
    • Direct effect on RPS2 versus bystander labeling not separated

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the multiple extraribosomal regulators of uS5 (chaperones, methylation, ZNF277, ubiquitination, RACK1) are coordinated in time and space, and how they feed back on translation fidelity, remains unresolved.
  • No integrated model linking modifications to ribosome function
  • Structural basis of the uS4-uS5 phospho-salt bridge unconfirmed
  • Functional role of arginine methylation undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 3 GO:0045182 translation regulator activity 3 GO:0003723 RNA binding 1
Localization
GO:0005730 nucleolus 3 GO:0005840 ribosome 3 GO:0005829 cytosol 2 GO:0005634 nucleus 1
Pathway
R-HSA-392499 Metabolism of proteins 3 R-HSA-8953854 Metabolism of RNA 2 R-HSA-1852241 Organelle biogenesis and maintenance 1
Partners
PDCD2PRMT3PSE1RACK1TSR4US4ZNF277
Complex memberships
40S small ribosomal subunitpre-40S particle

Evidence

Reading pass · 16 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2007 PRMT3 (a type I arginine methyltransferase) directly methylates ribosomal protein rpS2 (RPS2/uS5) at arginine residues; PRMT3 is tethered to ribosomes via its interaction with rpS2, which is also its substrate. In PRMT3-knockout mice, rpS2 is hypomethylated, establishing rpS2 as a bona fide in vivo PRMT3 substrate that cannot be compensated by other PRMTs. Targeted gene disruption (PRMT3 knockout mice), Western blot for methylarginine, ribosome fractionation (polysome profiling), co-fractionation assays The Journal of biological chemistry High 17439947
2009 In budding yeast Saccharomyces cerevisiae, which lacks a zinc-finger-containing Rmt3/PRMT3 homolog, Rps2 is partially modified to asymmetric dimethylarginine and monomethylarginine by the major arginine methyltransferase Rmt1, demonstrating organism-specific methyltransferase usage for the same substrate. Arginine methylation assays, methyltransferase deletion strains, mass spectrometry/biochemical detection of methylarginine Biochemical and biophysical research communications Medium 20035717
2008 In fission yeast, Rps2 is required for nuclear export competence of pre-40S ribosomal subunits; its depletion causes retention of pre-40S particles in the nucleolus, blocks 40S subunit production, and impairs cleavage at site A2 within 32S pre-rRNA. Genetic depletion of Rps2 in Schizosaccharomyces pombe, pre-rRNA processing analysis, rRNA pulse-chase assays, nucleolar retention assays Nucleic acids research High 18820293
2018 Human zinc finger protein ZNF277 forms an extraribosomal complex with uS5 (RPS2) in the cytoplasm and nucleolus using a C2H2-type zinc finger domain. ZNF277 and PRMT3 compete for uS5 binding: PRMT3 overexpression inhibits ZNF277-uS5 complex formation, and ZNF277 depletion increases uS5-PRMT3 levels. ZNF277 recognizes nascent uS5 co-translationally. Quantitative proteomics (affinity purification-MS), Co-IP in human cells, proximity ligation assay, overexpression/depletion experiments, subcellular fractionation The Journal of biological chemistry High 30530495
2019 Tsr4 is a dedicated cytoplasmic chaperone for Rps2 (uS5) in S. cerevisiae. Tsr4 associates with Rps2 co-translationally, requires the eukaryote-specific N-terminal extension of Rps2 for interaction, promotes Rps2 solubility and expression, and is restricted to the cytoplasm despite Rps2 assembling into nuclear pre-40S particles. Co-translational co-IP, genetic depletion/perturbation of Tsr4, ribosome biogenesis assays, subcellular fractionation, yeast genetics Molecular and cellular biology High 31182640
2020 Human PDCD2 functions as a dedicated ribosomal protein chaperone for uS5 (RPS2); PDCD2-uS5 complex is assembled co-translationally. Loss of PDCD2 impairs accumulation of soluble uS5 and its incorporation into 40S ribosomal subunits, causing defects in small ribosomal subunit synthesis that phenocopy uS5 deficiency. Quantitative proteomics (affinity purification-MS), co-translational Co-IP, PDCD2 knockdown with ribosome biogenesis readouts, polysome profiling Nucleic acids research High 33245768
2016 In Drosophila, Zfrp8/PDCD2 directly interacts with RpS2 (uS5) of the 40S small ribosomal subunit. Zfrp8/PDCD2 regulates cytoplasmic levels of 40S ribosomal subunit components and controls cytoplasmic localization of specific mRNAs; knockdown causes nuclear accumulation of specific mRNAs and TE transcripts, suggesting Zfrp8 functions at late stages of ribosome assembly. Co-IP (Zfrp8-RpS2 pulldown), fluorescent tagging of ribosomal proteins, genetic knockdown (RNAi), RNA localization assays PloS one Medium 26807849
2022 Ribosomal protein uS5/Rps2 residues at the mRNA entry channel of the 40S subunit influence start codon recognition in vivo; nonlethal substitutions of conserved Rps2 residues reduce bulk translation initiation, increase discrimination against poor initiation codons (near-cognate UUG and suboptimal Kozak context AUG), resembling substitutions in uS3/Rps3 and initiation factors eIF1/eIF1A. Site-directed mutagenesis of Rps2 residues, yeast genetic assays for translation initiation fidelity (UUG initiation reporters, Kozak context reporters), epistasis with known initiation mutants Genetics High 34791232
2017 Mutations in the loop 2 region (residues 20–31) of ribosomal protein uS5 in E. coli confer spectinomycin resistance and affect translational fidelity; a minority of loop 2 mutants also show altered rRNA processing or ribosome biogenesis defects, demonstrating that this region participates in subunit assembly and maintenance of translational accuracy. Site-directed mutagenesis (21 unique mutants), spectinomycin sensitivity assays, translational fidelity reporters, rRNA processing analysis Antimicrobial agents and chemotherapy High 27855073
2024 In S. cerevisiae, the cyclin-dependent kinase pathway (via Ypk2) phosphorylates Ser176 of uS5 (RPS2), which is located at the uS4-uS5 interface; phospho-Ser176 forms a salt bridge with Arg57 of uS4, strengthening the interface and increasing decoding selectivity. A second kinase pathway involving TORC1 and Pkc1 opposes this phosphorylation, indicating that translational accuracy is dynamically regulated by competing phosphorylation on uS5. Site-directed mutagenesis of Ser176 and Arg57, genetic epistasis analysis with kinase mutants (ctk1, ypk2, TORC1, pkc1), translational fidelity reporters Nucleic acids research Medium 38340338
2023 Nuclear import of Rps2 (uS5) in yeast requires two distinct import signals: (1) an internal region (amino acids 76–145) that interacts with the importin-β Pse1, with Arg95, Arg97, and Lys99 being critical determinants; (2) an N-terminal region (amino acids 10–28) containing basic residues that constitutes a second import pathway. Both pathways function independently of the dedicated chaperone Tsr4. GFP reporter nuclear import assays, deletion/mutation analysis of Rps2 import signals, Co-IP with Pse1, genetic dissection in yeast Biomolecules Medium 37509163
2022 Heliangin (a sesquiterpene lactone) covalently binds to the C222 site of RPS2, disrupting pre-rRNA metabolic processes, causing nucleolar stress, and activating the ribosomal proteins–MDM2–p53 pathway with consequent p53 stabilization in NPM1-mutant AML cells. Quantitative thiol reactivity platform screening, molecular biology validation, covalent binding assays, pre-rRNA processing assays, Western blot for p53/MDM2 Acta pharmaceutica Sinica. B Medium 36873185
2010 RPS2 specifically binds pre-let-7a-1 RNA and blocks its processing to mature let-7a/let-7f miRNA in prostate cancer cells; this was shown by EMSA, antibody supershift assay, and immunoprecipitation. Overexpression of RPS2 correlates with loss of let-7a and elevated ras/c-myc, while RPS2 knockdown restores let-7a and reduces oncogene expression and tumorigenesis. EMSA, antibody supershift assay, immunoprecipitation, stable transfection/shRNA knockdown, Northern blot, immunofluorescence, SCID mouse tumor model Molecular cancer research : MCR Medium 21148031
2025 RACK1 stabilizes RPS2 by inhibiting ubiquitin-mediated proteasomal degradation of RPS2; RACK1 knockdown increases RPS2 ubiquitination and accelerates its degradation (reversed by MG132). Both RACK1 and RPS2 positively regulate the NF-κB pathway, and RPS2 overexpression partially rescues the NF-κB inhibition caused by RACK1 knockdown in glioma cells. Co-immunoprecipitation, ubiquitination assays, MG132 proteasome inhibitor treatment, Western blot, NF-κB luciferase reporter assay, siRNA knockdown Molecular biology reports Medium 40522528
2026 A 30-amino-acid N-terminal region of uS5 (RPS2) is necessary and sufficient for interaction with its dedicated chaperone PDCD2; a conserved FxxGFG motif within this region mediates hydrophobic interactions with PDCD2. An 11-amino-acid uS5-derived peptide that inhibits PDCD2-uS5 interaction impairs cancer cell viability. Affinity purification assays, structural modeling, complementation-based biosensor in human cells and cell extracts, deletion/mutation analysis, cell viability assays The Journal of biological chemistry Medium 41933732
2025 In the absence of eIF2A, ubiquitination of RPS2 (and RPS3) is specifically diminished upon ribosome stalling, and eIF2A antagonizes USP10-dependent rescue of 40S ribosomes; this places RPS2 ubiquitination in a ribosome-associated quality control pathway regulated by eIF2A. TurboID proximity labeling combined with mass spectrometry, polysome gradient fractionation, eIF2A knockout cells, dynamic SILAC mass spectrometry, 40S footprinting bioRxivpreprint Low

Source papers

Stage 0 corpus · 44 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1994 The A. thaliana disease resistance gene RPS2 encodes a protein containing a nucleotide-binding site and leucine-rich repeats. Cell 492 7923358
1999 Herpes simplex virus inhibits apoptosis through the action of two genes, Us5 and Us3. Journal of virology 189 10516000
2005 Molecular basis for the RIN4 negative regulation of RPS2 disease resistance. The Plant cell 127 15749765
2007 Ribosomal protein rpS2 is hypomethylated in PRMT3-deficient mice. The Journal of biological chemistry 115 17439947
2009 RPS2: a novel therapeutic target in prostate cancer. Journal of experimental & clinical cancer research : CR 57 19138403
2017 Human Cytomegalovirus MicroRNAs miR-US5-1 and miR-UL112-3p Block Proinflammatory Cytokine Production in Response to NF-κB-Activating Factors through Direct Downregulation of IKKα and IKKβ. mBio 56 28270578
1998 Transcript analysis of the tobacco plastid operon rps2/atpI/H/F/A reveals the existence of a non-consensus type II (NCII) promoter upstream of the atpI coding sequence. Molecular & general genetics : MGG 43 9520264
2020 Ptr1 evolved convergently with RPS2 and Mr5 to mediate recognition of AvrRpt2 in diverse solanaceous species. The Plant journal : for cell and molecular biology 33 32391580
2021 Human Cytomegalovirus UL7, miR-US5-1, and miR-UL112-3p Inactivation of FOXO3a Protects CD34+ Hematopoietic Progenitor Cells from Apoptosis. mSphere 31 33408225
2007 Characterization of Components of Partial Resistance, Rps2, and Root Resistance to Phytophthora sojae in Soybean. Phytopathology 31 18943586
2018 The 40S ribosomal protein uS5 (RPS2) assembles into an extraribosomal complex with human ZNF277 that competes with the PRMT3-uS5 interaction. The Journal of biological chemistry 29 30530495
2020 Human Cytomegalovirus miR-US5-2 Downregulation of GAB1 Regulates Cellular Proliferation and UL138 Expression through Modulation of Epidermal Growth Factor Receptor Signaling Pathways. mSphere 26 32759334
2006 Herpes simplex virus genes Us3, Us5, and Us12 differentially regulate cytotoxic T lymphocyte-induced cytotoxicity. Viral immunology 26 16987059
2019 Tsr4 Is a Cytoplasmic Chaperone for the Ribosomal Protein Rps2 in Saccharomyces cerevisiae. Molecular and cellular biology 25 31182640
1984 Purification and characterization of Serratia marcescens US5 pili. Infection and immunity 24 6209220
2009 Rmt1 catalyzes zinc-finger independent arginine methylation of ribosomal protein Rps2 in Saccharomyces cerevisiae. Biochemical and biophysical research communications 23 20035717
2020 PDCD2 functions as an evolutionarily conserved chaperone dedicated for the 40S ribosomal protein uS5 (RPS2). Nucleic acids research 22 33245768
2008 Nuclear export competence of pre-40S subunits in fission yeast requires the ribosomal protein Rps2. Nucleic acids research 21 18820293
2002 Plant mitochondrial rps2 genes code for proteins with a C-terminal extension that is processed. Plant molecular biology 20 12369627
1998 The US5 open reading frame of herpes simplex virus type 1 does encode a glycoprotein (gJ). Intervirology 20 9820842
2023 Ribosomal Protein uS5 and Friends: Protein-Protein Interactions Involved in Ribosome Assembly and Beyond. Biomolecules 18 37238722
2019 Molecular characterization and antiapoptotic function analysis of the duck plague virus Us5 gene. Scientific reports 15 30890748
2016 Zfrp8/PDCD2 Interacts with RpS2 Connecting Ribosome Maturation and Gene-Specific Translation. PloS one 15 26807849
2010 Role of ribosomal protein RPS2 in controlling let-7a expression in human prostate cancer. Molecular cancer research : MCR 15 21148031
2017 Human cytomegalovirus miR-US5-1 inhibits viral replication by targeting Geminin mRNA. Virologica Sinica 14 29116593
2019 RNAi mediated knockdown of RpL11, RpS2, and tra-2 led to reduced reproduction of Phytoseiulus persimilis. Experimental & applied acarology 13 31375950
2002 Pharmacognostical studies of cistanchis herba (III) phylogenetic relationship of the cistanche plants based on plastid rps2 gene and rpl16-rpl14 intergenic spacer sequences. Biological & pharmaceutical bulletin 10 11853170
2022 Silencing of long chain noncoding RNA paternally expressed gene (PEG10) inhibits the progression of neuroblastoma by regulating microRNA-449a (miR-449a)/ribosomal protein S2 (RPS2) axis. Bioengineered 9 35212607
2017 The Loop 2 Region of Ribosomal Protein uS5 Influences Spectinomycin Sensitivity, Translational Fidelity, and Ribosome Biogenesis. Antimicrobial agents and chemotherapy 9 27855073
2009 Molecular analysis of duck enteritis virus US3, US4, and US5 gene. Virus genes 9 19153825
1997 Deletion of the S component inverted repeat sequence c' and the nonessential genes U(S)1 through U(S)5 from the herpes simplex virus type 1 genome substantially impairs productive viral infection in cell culture and pathogenesis in the rat central nervous system. Journal of neurovirology 9 9291233
1991 A developmentally regulated gene encodes the dictyostelium homolog of yeast ribosomal protein S4 and mammalian LLRep3 proteins. Nucleic acids research 9 1861979
2022 uS5/Rps2 residues at the 40S ribosome entry channel enhance initiation at suboptimal start codons in vivo. Genetics 8 34791232
2023 Dissecting the Nuclear Import of the Ribosomal Protein Rps2 (uS5). Biomolecules 7 37509163
1998 A gene coding for an RPS2 protein is present in the mitochondrial genome of several cereals, but not in dicotyledons. Molecular & general genetics : MGG 7 9669335
2023 DNA methylation-mediated epigenetic regulation of oncogenic RPS2 as a novel therapeutic target and biomarker in hepatocellular carcinoma. Biochemical and biophysical research communications 5 38181486
2005 Structural and distributional variation of mitochondrial rps2 genes in the tribe Triticeae (Poaceae). TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik 5 15754209
2010 The novel HSV-1 US5-1 RNA is transcribed off a domain encoding US5, US4, US3, US2 and alpha22. Virology journal 4 20492679
2022 Heliangin acts as a covalent ligand of RPS2 that disrupts pre-rRNA metabolic processes in NPM1-mutated acute myeloid leukemia. Acta pharmaceutica Sinica. B 3 36873185
2024 An evolutionarily conserved phosphoserine-arginine salt bridge in the interface between ribosomal proteins uS4 and uS5 regulates translational accuracy in Saccharomyces cerevisiae. Nucleic acids research 2 38340338
2026 Estrogen-Induced Hypermethylation Silencing of RPS2 and TMEM177 Inhibits Energy Metabolism and Reduces the Survival of CRC Cells. Cells 0 41597199
2026 Biosensor-guided discovery of peptide inhibitors targeting the ribosomal protein uS5-PDCD2 chaperone interaction. The Journal of biological chemistry 0 41933732
2025 RACK1 promotes NF-κB pathway activation and glioma cell proliferation by inhibiting RPS2 ubiquitination. Molecular biology reports 0 40522528
2025 Mutations in ribosomal protein uS5 alter translation fidelity and mutagenesis in Pseudomonas putida. Journal of bacteriology 0 41222263

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