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Showing TUBE1TUBE is a alias.

TUBE1

Tubulin epsilon chain · UniProt Q9UJT0

Length
475 aa
Mass
52.9 kDa
Annotated
2026-06-10
100 papers in source corpus

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

No mechanistic discoveries found in literature.

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
No controlled-vocabulary terms were assigned to this entry.

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2003 Tube morphogenesis: making and shaping biological tubes. Cell 533 12526790
1976 Vitamin deficiencies and neural tube defects. Archives of disease in childhood 443 1015847
2015 DNA nanotechnology from the test tube to the cell. Nature nanotechnology 420 26329111
2017 Neural tube closure: cellular, molecular and biomechanical mechanisms. Development (Cambridge, England) 379 28196803
2010 Genetics and development of neural tube defects. The Journal of pathology 337 19918803
2008 Programming DNA tube circumferences. Science (New York, N.Y.) 315 18687961
2017 Isothermal Amplification for MicroRNA Detection: From the Test Tube to the Cell. Accounts of chemical research 280 28355077
2010 An update to the list of mouse mutants with neural tube closure defects and advances toward a complete genetic perspective of neural tube closure. Birth defects research. Part A, Clinical and molecular teratology 258 20740593
2007 Mouse mutants with neural tube closure defects and their role in understanding human neural tube defects. Birth defects research. Part A, Clinical and molecular teratology 250 17177317
2009 Genetics of human neural tube defects. Human molecular genetics 226 19808787
2018 Cancer of the ovary, fallopian tube, and peritoneum. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 220 30306591
2019 A Fruitful Journey: Pollen Tube Navigation from Germination to Fertilization. Annual review of plant biology 198 30822112
2003 Epidemiology of neural tube defects. Epilepsia 183 12790881
2005 Epidemiology of neural tube defects. American journal of medical genetics. Part C, Seminars in medical genetics 182 15800877
2006 Etiology, pathogenesis and prevention of neural tube defects. Congenital anomalies 163 16732763
1989 Pollen tube tip growth. The New phytologist 129 33874021
2010 Secretory cell outgrowth, PAX2 and serous carcinogenesis in the Fallopian tube. The Journal of pathology 120 20597068
2001 Actin and pollen tube growth. Protoplasma 119 11732066
2000 Spina bifida and other neural tube defects. Current problems in pediatrics 113 11147289
2004 Homeobox A9 transcriptionally regulates the EphB4 receptor to modulate endothelial cell migration and tube formation. Circulation research 111 14764452
1999 Oligomerisation of Tube and Pelle leads to nuclear localisation of dorsal. Mechanisms of development 111 10330490
2005 The microsporidian polar tube: a highly specialised invasion organelle. International journal for parasitology 103 16005007
1997 Germ tube growth of Candida albicans. Current topics in medical mycology 101 9504066
2015 Peptide signalling during the pollen tube journey and double fertilization. Journal of experimental botany 99 26068467
2014 Pollen tube growth: where does the energy come from? Plant signaling & behavior 85 25482752
2000 The role of Sonic hedgehog in neural tube patterning. Cellular and molecular life sciences : CMLS 85 11130176
2001 Patterning the protochordate neural tube. Current opinion in neurobiology 83 11179867
2003 Pollen-tube guidance: beacons from the female gametophyte. Current opinion in plant biology 78 12495749
1994 Folic acid metabolism and mechanisms of neural tube defects. Ciba Foundation symposium 78 8005024
2015 The cytoskeleton in the pollen tube. Current opinion in plant biology 70 26550939
2021 Actuation enhances patterning in human neural tube organoids. Nature communications 69 34045434
1996 Homocysteine and neural tube defects. The Journal of nutrition 69 8598561
1995 Malnutrition, tube feeding and pressure sores: data are incomplete. Journal of the American Geriatrics Society 69 7706638
2021 Axial elongation of caudalized human organoids mimics aspects of neural tube development. Development (Cambridge, England) 66 34142711
2003 Pathobiology and genetics of neural tube defects. Epilepsia 64 12790882
2017 Inositol, neural tube closure and the prevention of neural tube defects. Birth defects research 63 27324558
2008 CB1 expression is attenuated in Fallopian tube and decidua of women with ectopic pregnancy. PloS one 63 19093002
2018 Chemical signaling for pollen tube guidance at a glance. Journal of cell science 59 29378835
2019 Pollen tube integrity regulation in flowering plants: insights from molecular assemblies on the pollen tube surface. The New phytologist 58 30556141
2017 Structural basis for receptor recognition of pollen tube attraction peptides. Nature communications 57 29109411
2011 Drosophila as a model for epithelial tube formation. Developmental dynamics : an official publication of the American Association of Anatomists 52 22083894
2010 Tube continued: morphogenesis of the Drosophila tracheal system. Current opinion in cell biology 51 20739171
2004 Investigations into the etiology of neural tube defects. Birth defects research. Part C, Embryo today : reviews 51 15662706
2000 Control of Shh activity and signaling in the neural tube. Developmental dynamics : an official publication of the American Association of Anatomists 51 11002335
2009 Uncovering hidden treasures in pollen tube growth mechanics. Trends in plant science 49 19446491
2020 Architecture of the flexible tail tube of bacteriophage SPP1. Nature communications 48 33188213
2009 Diabetes and apoptosis: neural crest cells and neural tube. Apoptosis : an international journal on programmed cell death 47 19333760
2012 Epithelial fusion during neural tube morphogenesis. Birth defects research. Part A, Clinical and molecular teratology 46 22945349
2015 Mutant p53 expression in fallopian tube epithelium drives cell migration. International journal of cancer 44 25810107
1986 Human fallopian tube contains placental protein 14. American journal of obstetrics and gynecology 44 3518461
2021 Mechanics and hydraulics of pollen tube growth. The New phytologist 42 34492127
2015 Peptide signaling in pollen tube guidance. Current opinion in plant biology 42 26580200
2014 TRPM7 regulates vascular endothelial cell adhesion and tube formation. American journal of physiology. Cell physiology 41 25472964
2006 Rac function in epithelial tube morphogenesis. Developmental biology 41 16412417
2008 Grainyhead genes and mammalian neural tube closure. Birth defects research. Part A, Clinical and molecular teratology 40 18683893
1998 Cell lineage in the developing neural tube. Biochemistry and cell biology = Biochimie et biologie cellulaire 40 10392716
1994 Periconceptional folate and neural tube defect. The American journal of clinical nutrition 40 8304289
2014 RFX7 is required for the formation of cilia in the neural tube. Mechanisms of development 39 24530844
2005 Epithelial cell polarity genes are required for neural tube closure. American journal of medical genetics. Part C, Seminars in medical genetics 38 15800847
2018 Sonic hedgehog in vertebrate neural tube development. The International journal of developmental biology 37 29616731
2012 The pollen tube paradigm revisited. Current opinion in plant biology 36 23000432
2019 Variants identified in PTK7 associated with neural tube defects. Molecular genetics & genomic medicine 35 30689296
2015 Tumorigenesis and peritoneal colonization from fallopian tube epithelium. Oncotarget 35 25971410
2005 Non-multifactorial neural tube defects. American journal of medical genetics. Part C, Seminars in medical genetics 35 15800854
2018 Cell mechanics of pollen tube growth. Current opinion in genetics & development 34 29602058
2016 Molecular Signaling Pathways Controlling Vascular Tube Morphogenesis and Pericyte-Induced Tube Maturation in 3D Extracellular Matrices. Advances in pharmacology (San Diego, Calif.) 34 27451100
2010 Female gametophyte-controlled pollen tube guidance. Biochemical Society transactions 34 20298233
2016 Microtubules, polarity and vertebrate neural tube morphogenesis. Journal of anatomy 33 27025884
2012 Neural tube defects by NUAK1 and NUAK2 double mutation. Developmental dynamics : an official publication of the American Association of Anatomists 32 22689267
2019 Fallopian Tube Carcinoma. Journal of oncology practice 28 31283415
2018 NMDA Receptor Signaling Is Important for Neural Tube Formation and for Preventing Antiepileptic Drug-Induced Neural Tube Defects. The Journal of neuroscience : the official journal of the Society for Neuroscience 27 29712790
2013 Endothelial connexin32 enhances angiogenesis by positively regulating tube formation and cell migration. Experimental cell research 27 24333598
1998 Neural tube defects, vitamins and homocysteine. European journal of pediatrics 27 9587043
1997 Differentiation of the vertebrate neural tube. Current opinion in cell biology 27 9425355
2021 TP53 loss initiates chromosomal instability in fallopian tube epithelial cells. Disease models & mechanisms 26 34569598
2019 New developments in tube shunt surgery. Current opinion in ophthalmology 26 30562244
2003 Tube morphogenesis: closure, but many openings remain. Trends in cell biology 26 14624839
2020 Mechanics of Pollen Tube Elongation: A Perspective. Frontiers in plant science 25 33193543
2017 Genetic epidemiology of neural tube defects. Journal of pediatric rehabilitation medicine 25 29125517
2014 Tube fusion: making connections in branched tubular networks. Seminars in cell & developmental biology 24 24662893
2004 Expression of fractalkine in the Fallopian tube and of CX3CR1 in sperm. Human reproduction (Oxford, England) 24 14747189
1981 RNA, proteins and polyamines during tube growth in germinating apple pollen. Plant physiology 24 16661988
2017 Signaling Networks in Epithelial Tube Formation. Cold Spring Harbor perspectives in biology 23 28246178
2016 Nodal and FGF coordinate ascidian neural tube morphogenesis. Development (Cambridge, England) 23 27827820
2012 Apicobasal polarity and neural tube closure. Development, growth & differentiation 23 23277919
2008 Modeling neural tube defects in the mouse. Current topics in developmental biology 23 19186242
2018 Blood Glucose Determination: Effect of Tube Additives. Advances in clinical chemistry 22 29478513
2008 Tube formation in Drosophila egg chambers. Tissue engineering. Part A 22 18707228
2020 An ontology for developmental processes and toxicities of neural tube closure. Reproductive toxicology (Elmsford, N.Y.) 21 32926990
2016 Tube-Forming Assays. Methods in molecular biology (Clifton, N.J.) 21 27172951
2015 Nutri-epigenomic Studies Related to Neural Tube Defects: Does Folate Affect Neural Tube Closure Via Changes in DNA Methylation? Mini reviews in medicinal chemistry 21 26349489
2011 MIM regulates vertebrate neural tube closure. Development (Cambridge, England) 21 21471152
2017 Claudins in morphogenesis: Forming an epithelial tube. Tissue barriers 19 28837393
1999 Folate status and neural tube defects. BioFactors (Oxford, England) 19 10609896
2021 A polarity pathway for exocyst-dependent intracellular tube extension. eLife 18 33687331
2019 Advances in Eustachian tube function testing. World journal of otorhinolaryngology - head and neck surgery 18 31750424
2001 Screening for neural tube defects. Clinics in perinatology 18 11499052
2013 Imaging of primary fallopian tube carcinoma. Abdominal imaging 17 22707217
2003 Is there more to folates than neural-tube defects? The Proceedings of the Nutrition Society 17 14692594
2000 One tube mutation detection using sensitive fluorescent dyeing of MutS protected DNA. Nucleic acids research 17 10734213

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