{"gene":"TUBE1","run_date":"2026-06-10T10:51:56","timeline":{"discoveries":[],"current_model":"No mechanistic findings in the available literature."},"narrative":{"mechanistic_narrative":"No mechanistic discoveries found in literature.","teleology":[],"mechanism_profile":null},"prefetch_data":{"uniprot":{"accession":"Q9UJT0","full_name":"Tubulin epsilon chain","aliases":["Epsilon-tubulin"],"length_aa":475,"mass_kda":52.9,"function":"","subcellular_location":"Cytoplasm, cytoskeleton, microtubule organizing center, centrosome","url":"https://www.uniprot.org/uniprotkb/Q9UJT0/entry"},"depmap":{"release":"DepMap","has_data":true,"is_common_essential":true,"resolved_as":"","url":"https://depmap.org/portal/gene/TUBE1","classification":"Common Essential","n_dependent_lines":728,"n_total_lines":1208,"dependency_fraction":0.6026490066225165},"opencell":{"profiled":false,"resolved_as":"","ensg_id":"","cell_line_id":"","localizations":[],"interactors":[{"gene":"NPM1","stoichiometry":0.2}],"url":"https://opencell.sf.czbiohub.org/search/TUBE1","total_profiled":1310},"omim":[{"mim_id":"620217","title":"CENTROSOMAL PROTEIN, 44-KD; CEP44","url":"https://www.omim.org/entry/620217"},{"mim_id":"607345","title":"TUBULIN, EPSILON-1; TUBE1","url":"https://www.omim.org/entry/607345"}],"hpa":{"profiled":true,"resolved_as":"","reliability":"","locations":[],"tissue_specificity":"Low tissue specificity","tissue_distribution":"Detected in all","driving_tissues":[],"url":"https://www.proteinatlas.org/search/TUBE1"},"hgnc":{"alias_symbol":["dJ142L7.2","FLJ22589","TUBE"],"prev_symbol":[]},"alphafold":{"accession":"Q9UJT0","domains":[{"cath_id":"3.40.50.1440","chopping":"4-217_263-275","consensus_level":"medium","plddt":93.3541,"start":4,"end":275},{"cath_id":"3.30.1330.20","chopping":"303-407","consensus_level":"medium","plddt":90.0738,"start":303,"end":407},{"cath_id":"1.10.287,1.10.287","chopping":"408-461","consensus_level":"medium","plddt":95.9967,"start":408,"end":461}],"viewer_url":"https://alphafold.ebi.ac.uk/entry/Q9UJT0","model_url":"https://alphafold.ebi.ac.uk/files/AF-Q9UJT0-F1-model_v6.cif","pae_url":"https://alphafold.ebi.ac.uk/files/AF-Q9UJT0-F1-predicted_aligned_error_v6.png","plddt_mean":88.75},"mouse_models":{"mgi_url":"https://www.informatics.jax.org/marker/summary?nomen=TUBE1","jax_strain_url":"https://www.jax.org/strain/search?query=TUBE1"},"sequence":{"accession":"Q9UJT0","fasta_url":"https://rest.uniprot.org/uniprotkb/Q9UJT0.fasta","uniprot_url":"https://www.uniprot.org/uniprotkb/Q9UJT0/entry","alphafold_viewer_url":"https://alphafold.ebi.ac.uk/entry/Q9UJT0"}},"corpus_meta":[{"pmid":"12526790","id":"PMC_12526790","title":"Tube morphogenesis: making and shaping biological tubes.","date":"2003","source":"Cell","url":"https://pubmed.ncbi.nlm.nih.gov/12526790","citation_count":533,"is_preprint":false},{"pmid":"1015847","id":"PMC_1015847","title":"Vitamin deficiencies and neural tube defects.","date":"1976","source":"Archives of disease in childhood","url":"https://pubmed.ncbi.nlm.nih.gov/1015847","citation_count":443,"is_preprint":false},{"pmid":"26329111","id":"PMC_26329111","title":"DNA nanotechnology from the test tube to the cell.","date":"2015","source":"Nature nanotechnology","url":"https://pubmed.ncbi.nlm.nih.gov/26329111","citation_count":420,"is_preprint":false},{"pmid":"28196803","id":"PMC_28196803","title":"Neural tube closure: cellular, molecular and biomechanical mechanisms.","date":"2017","source":"Development (Cambridge, England)","url":"https://pubmed.ncbi.nlm.nih.gov/28196803","citation_count":379,"is_preprint":false},{"pmid":"19918803","id":"PMC_19918803","title":"Genetics and development of neural tube defects.","date":"2010","source":"The Journal of pathology","url":"https://pubmed.ncbi.nlm.nih.gov/19918803","citation_count":337,"is_preprint":false},{"pmid":"18687961","id":"PMC_18687961","title":"Programming DNA tube circumferences.","date":"2008","source":"Science (New York, N.Y.)","url":"https://pubmed.ncbi.nlm.nih.gov/18687961","citation_count":315,"is_preprint":false},{"pmid":"28355077","id":"PMC_28355077","title":"Isothermal Amplification for MicroRNA Detection: From the Test Tube to the Cell.","date":"2017","source":"Accounts of chemical research","url":"https://pubmed.ncbi.nlm.nih.gov/28355077","citation_count":280,"is_preprint":false},{"pmid":"20740593","id":"PMC_20740593","title":"An update to the list of mouse mutants with neural tube closure defects and advances toward a complete genetic perspective of neural tube closure.","date":"2010","source":"Birth defects research. Part A, Clinical and molecular teratology","url":"https://pubmed.ncbi.nlm.nih.gov/20740593","citation_count":258,"is_preprint":false},{"pmid":"17177317","id":"PMC_17177317","title":"Mouse mutants with neural tube closure defects and their role in understanding human neural tube defects.","date":"2007","source":"Birth defects research. Part A, Clinical and molecular teratology","url":"https://pubmed.ncbi.nlm.nih.gov/17177317","citation_count":250,"is_preprint":false},{"pmid":"19808787","id":"PMC_19808787","title":"Genetics of human neural tube defects.","date":"2009","source":"Human molecular genetics","url":"https://pubmed.ncbi.nlm.nih.gov/19808787","citation_count":226,"is_preprint":false},{"pmid":"30306591","id":"PMC_30306591","title":"Cancer of the ovary, fallopian tube, and peritoneum.","date":"2018","source":"International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics","url":"https://pubmed.ncbi.nlm.nih.gov/30306591","citation_count":220,"is_preprint":false},{"pmid":"30822112","id":"PMC_30822112","title":"A Fruitful Journey: Pollen Tube Navigation from Germination to Fertilization.","date":"2019","source":"Annual review of plant biology","url":"https://pubmed.ncbi.nlm.nih.gov/30822112","citation_count":198,"is_preprint":false},{"pmid":"12790881","id":"PMC_12790881","title":"Epidemiology of neural tube defects.","date":"2003","source":"Epilepsia","url":"https://pubmed.ncbi.nlm.nih.gov/12790881","citation_count":183,"is_preprint":false},{"pmid":"15800877","id":"PMC_15800877","title":"Epidemiology of neural tube defects.","date":"2005","source":"American journal of medical genetics. Part C, Seminars in medical genetics","url":"https://pubmed.ncbi.nlm.nih.gov/15800877","citation_count":182,"is_preprint":false},{"pmid":"16732763","id":"PMC_16732763","title":"Etiology, pathogenesis and prevention of neural tube defects.","date":"2006","source":"Congenital anomalies","url":"https://pubmed.ncbi.nlm.nih.gov/16732763","citation_count":163,"is_preprint":false},{"pmid":"33874021","id":"PMC_33874021","title":"Pollen tube tip growth.","date":"1989","source":"The New phytologist","url":"https://pubmed.ncbi.nlm.nih.gov/33874021","citation_count":129,"is_preprint":false},{"pmid":"20597068","id":"PMC_20597068","title":"Secretory cell outgrowth, PAX2 and serous carcinogenesis in the Fallopian tube.","date":"2010","source":"The Journal of pathology","url":"https://pubmed.ncbi.nlm.nih.gov/20597068","citation_count":120,"is_preprint":false},{"pmid":"11732066","id":"PMC_11732066","title":"Actin and pollen tube growth.","date":"2001","source":"Protoplasma","url":"https://pubmed.ncbi.nlm.nih.gov/11732066","citation_count":119,"is_preprint":false},{"pmid":"11147289","id":"PMC_11147289","title":"Spina bifida and other neural tube defects.","date":"2000","source":"Current problems in pediatrics","url":"https://pubmed.ncbi.nlm.nih.gov/11147289","citation_count":113,"is_preprint":false},{"pmid":"10330490","id":"PMC_10330490","title":"Oligomerisation of Tube and Pelle leads to nuclear localisation of dorsal.","date":"1999","source":"Mechanisms of development","url":"https://pubmed.ncbi.nlm.nih.gov/10330490","citation_count":111,"is_preprint":false},{"pmid":"14764452","id":"PMC_14764452","title":"Homeobox A9 transcriptionally regulates the EphB4 receptor to modulate endothelial cell migration and tube formation.","date":"2004","source":"Circulation research","url":"https://pubmed.ncbi.nlm.nih.gov/14764452","citation_count":111,"is_preprint":false},{"pmid":"16005007","id":"PMC_16005007","title":"The microsporidian polar tube: a highly specialised invasion organelle.","date":"2005","source":"International journal for parasitology","url":"https://pubmed.ncbi.nlm.nih.gov/16005007","citation_count":103,"is_preprint":false},{"pmid":"9504066","id":"PMC_9504066","title":"Germ tube growth of Candida albicans.","date":"1997","source":"Current topics in medical mycology","url":"https://pubmed.ncbi.nlm.nih.gov/9504066","citation_count":101,"is_preprint":false},{"pmid":"26068467","id":"PMC_26068467","title":"Peptide signalling during the pollen tube journey and double fertilization.","date":"2015","source":"Journal of experimental botany","url":"https://pubmed.ncbi.nlm.nih.gov/26068467","citation_count":99,"is_preprint":false},{"pmid":"25482752","id":"PMC_25482752","title":"Pollen tube growth: where does the energy come from?","date":"2014","source":"Plant signaling & behavior","url":"https://pubmed.ncbi.nlm.nih.gov/25482752","citation_count":85,"is_preprint":false},{"pmid":"11130176","id":"PMC_11130176","title":"The role of Sonic hedgehog in neural tube patterning.","date":"2000","source":"Cellular and molecular life sciences : CMLS","url":"https://pubmed.ncbi.nlm.nih.gov/11130176","citation_count":85,"is_preprint":false},{"pmid":"11179867","id":"PMC_11179867","title":"Patterning the protochordate neural tube.","date":"2001","source":"Current opinion in neurobiology","url":"https://pubmed.ncbi.nlm.nih.gov/11179867","citation_count":83,"is_preprint":false},{"pmid":"8005024","id":"PMC_8005024","title":"Folic acid metabolism and mechanisms of neural tube defects.","date":"1994","source":"Ciba Foundation symposium","url":"https://pubmed.ncbi.nlm.nih.gov/8005024","citation_count":78,"is_preprint":false},{"pmid":"12495749","id":"PMC_12495749","title":"Pollen-tube guidance: beacons from the female gametophyte.","date":"2003","source":"Current opinion in plant biology","url":"https://pubmed.ncbi.nlm.nih.gov/12495749","citation_count":78,"is_preprint":false},{"pmid":"26550939","id":"PMC_26550939","title":"The cytoskeleton in the pollen tube.","date":"2015","source":"Current opinion in plant biology","url":"https://pubmed.ncbi.nlm.nih.gov/26550939","citation_count":70,"is_preprint":false},{"pmid":"8598561","id":"PMC_8598561","title":"Homocysteine and neural tube defects.","date":"1996","source":"The Journal of nutrition","url":"https://pubmed.ncbi.nlm.nih.gov/8598561","citation_count":69,"is_preprint":false},{"pmid":"34045434","id":"PMC_34045434","title":"Actuation enhances patterning in human neural tube organoids.","date":"2021","source":"Nature communications","url":"https://pubmed.ncbi.nlm.nih.gov/34045434","citation_count":69,"is_preprint":false},{"pmid":"7706638","id":"PMC_7706638","title":"Malnutrition, tube feeding and pressure sores: data are incomplete.","date":"1995","source":"Journal of the American Geriatrics Society","url":"https://pubmed.ncbi.nlm.nih.gov/7706638","citation_count":69,"is_preprint":false},{"pmid":"34142711","id":"PMC_34142711","title":"Axial elongation of caudalized human organoids mimics aspects of neural tube development.","date":"2021","source":"Development (Cambridge, England)","url":"https://pubmed.ncbi.nlm.nih.gov/34142711","citation_count":66,"is_preprint":false},{"pmid":"12790882","id":"PMC_12790882","title":"Pathobiology and genetics of neural tube defects.","date":"2003","source":"Epilepsia","url":"https://pubmed.ncbi.nlm.nih.gov/12790882","citation_count":64,"is_preprint":false},{"pmid":"27324558","id":"PMC_27324558","title":"Inositol, neural tube closure and the prevention of neural tube defects.","date":"2017","source":"Birth defects research","url":"https://pubmed.ncbi.nlm.nih.gov/27324558","citation_count":63,"is_preprint":false},{"pmid":"19093002","id":"PMC_19093002","title":"CB1 expression is attenuated in Fallopian tube and decidua of women with ectopic pregnancy.","date":"2008","source":"PloS one","url":"https://pubmed.ncbi.nlm.nih.gov/19093002","citation_count":63,"is_preprint":false},{"pmid":"29378835","id":"PMC_29378835","title":"Chemical signaling for pollen tube guidance at a glance.","date":"2018","source":"Journal of cell science","url":"https://pubmed.ncbi.nlm.nih.gov/29378835","citation_count":59,"is_preprint":false},{"pmid":"30556141","id":"PMC_30556141","title":"Pollen tube integrity regulation in flowering plants: insights from molecular assemblies on the pollen tube surface.","date":"2019","source":"The New phytologist","url":"https://pubmed.ncbi.nlm.nih.gov/30556141","citation_count":58,"is_preprint":false},{"pmid":"29109411","id":"PMC_29109411","title":"Structural basis for receptor recognition of pollen tube attraction peptides.","date":"2017","source":"Nature communications","url":"https://pubmed.ncbi.nlm.nih.gov/29109411","citation_count":57,"is_preprint":false},{"pmid":"22083894","id":"PMC_22083894","title":"Drosophila as a model for epithelial tube formation.","date":"2011","source":"Developmental dynamics : an official publication of the American Association of Anatomists","url":"https://pubmed.ncbi.nlm.nih.gov/22083894","citation_count":52,"is_preprint":false},{"pmid":"15662706","id":"PMC_15662706","title":"Investigations into the etiology of neural tube defects.","date":"2004","source":"Birth defects research. Part C, Embryo today : reviews","url":"https://pubmed.ncbi.nlm.nih.gov/15662706","citation_count":51,"is_preprint":false},{"pmid":"11002335","id":"PMC_11002335","title":"Control of Shh activity and signaling in the neural tube.","date":"2000","source":"Developmental dynamics : an official publication of the American Association of Anatomists","url":"https://pubmed.ncbi.nlm.nih.gov/11002335","citation_count":51,"is_preprint":false},{"pmid":"20739171","id":"PMC_20739171","title":"Tube continued: morphogenesis of the Drosophila tracheal system.","date":"2010","source":"Current opinion in cell biology","url":"https://pubmed.ncbi.nlm.nih.gov/20739171","citation_count":51,"is_preprint":false},{"pmid":"19446491","id":"PMC_19446491","title":"Uncovering hidden treasures in pollen tube growth mechanics.","date":"2009","source":"Trends in plant science","url":"https://pubmed.ncbi.nlm.nih.gov/19446491","citation_count":49,"is_preprint":false},{"pmid":"33188213","id":"PMC_33188213","title":"Architecture of the flexible tail tube of bacteriophage SPP1.","date":"2020","source":"Nature communications","url":"https://pubmed.ncbi.nlm.nih.gov/33188213","citation_count":48,"is_preprint":false},{"pmid":"19333760","id":"PMC_19333760","title":"Diabetes and apoptosis: neural crest cells and neural tube.","date":"2009","source":"Apoptosis : an international journal on programmed cell death","url":"https://pubmed.ncbi.nlm.nih.gov/19333760","citation_count":47,"is_preprint":false},{"pmid":"22945349","id":"PMC_22945349","title":"Epithelial fusion during neural tube morphogenesis.","date":"2012","source":"Birth defects research. Part A, Clinical and molecular teratology","url":"https://pubmed.ncbi.nlm.nih.gov/22945349","citation_count":46,"is_preprint":false},{"pmid":"25810107","id":"PMC_25810107","title":"Mutant p53 expression in fallopian tube epithelium drives cell migration.","date":"2015","source":"International journal of cancer","url":"https://pubmed.ncbi.nlm.nih.gov/25810107","citation_count":44,"is_preprint":false},{"pmid":"3518461","id":"PMC_3518461","title":"Human fallopian tube contains placental protein 14.","date":"1986","source":"American journal of obstetrics and gynecology","url":"https://pubmed.ncbi.nlm.nih.gov/3518461","citation_count":44,"is_preprint":false},{"pmid":"34492127","id":"PMC_34492127","title":"Mechanics and hydraulics of pollen tube growth.","date":"2021","source":"The New phytologist","url":"https://pubmed.ncbi.nlm.nih.gov/34492127","citation_count":42,"is_preprint":false},{"pmid":"26580200","id":"PMC_26580200","title":"Peptide signaling in pollen tube guidance.","date":"2015","source":"Current opinion in plant biology","url":"https://pubmed.ncbi.nlm.nih.gov/26580200","citation_count":42,"is_preprint":false},{"pmid":"25472964","id":"PMC_25472964","title":"TRPM7 regulates vascular endothelial cell adhesion and tube formation.","date":"2014","source":"American journal of physiology. Cell physiology","url":"https://pubmed.ncbi.nlm.nih.gov/25472964","citation_count":41,"is_preprint":false},{"pmid":"16412417","id":"PMC_16412417","title":"Rac function in epithelial tube morphogenesis.","date":"2006","source":"Developmental biology","url":"https://pubmed.ncbi.nlm.nih.gov/16412417","citation_count":41,"is_preprint":false},{"pmid":"18683893","id":"PMC_18683893","title":"Grainyhead genes and mammalian neural tube closure.","date":"2008","source":"Birth defects research. Part A, Clinical and molecular teratology","url":"https://pubmed.ncbi.nlm.nih.gov/18683893","citation_count":40,"is_preprint":false},{"pmid":"8304289","id":"PMC_8304289","title":"Periconceptional folate and neural tube defect.","date":"1994","source":"The American journal of clinical nutrition","url":"https://pubmed.ncbi.nlm.nih.gov/8304289","citation_count":40,"is_preprint":false},{"pmid":"10392716","id":"PMC_10392716","title":"Cell lineage in the developing neural tube.","date":"1998","source":"Biochemistry and cell biology = Biochimie et biologie cellulaire","url":"https://pubmed.ncbi.nlm.nih.gov/10392716","citation_count":40,"is_preprint":false},{"pmid":"24530844","id":"PMC_24530844","title":"RFX7 is required for the formation of cilia in the neural tube.","date":"2014","source":"Mechanisms of development","url":"https://pubmed.ncbi.nlm.nih.gov/24530844","citation_count":39,"is_preprint":false},{"pmid":"15800847","id":"PMC_15800847","title":"Epithelial cell polarity genes are required for neural tube closure.","date":"2005","source":"American journal of medical genetics. Part C, Seminars in medical genetics","url":"https://pubmed.ncbi.nlm.nih.gov/15800847","citation_count":38,"is_preprint":false},{"pmid":"29616731","id":"PMC_29616731","title":"Sonic hedgehog in vertebrate neural tube development.","date":"2018","source":"The International journal of developmental biology","url":"https://pubmed.ncbi.nlm.nih.gov/29616731","citation_count":37,"is_preprint":false},{"pmid":"23000432","id":"PMC_23000432","title":"The pollen tube paradigm revisited.","date":"2012","source":"Current opinion in plant biology","url":"https://pubmed.ncbi.nlm.nih.gov/23000432","citation_count":36,"is_preprint":false},{"pmid":"15800854","id":"PMC_15800854","title":"Non-multifactorial neural tube defects.","date":"2005","source":"American journal of medical genetics. Part C, Seminars in medical genetics","url":"https://pubmed.ncbi.nlm.nih.gov/15800854","citation_count":35,"is_preprint":false},{"pmid":"25971410","id":"PMC_25971410","title":"Tumorigenesis and peritoneal colonization from fallopian tube epithelium.","date":"2015","source":"Oncotarget","url":"https://pubmed.ncbi.nlm.nih.gov/25971410","citation_count":35,"is_preprint":false},{"pmid":"30689296","id":"PMC_30689296","title":"Variants identified in PTK7 associated with neural tube defects.","date":"2019","source":"Molecular genetics & genomic medicine","url":"https://pubmed.ncbi.nlm.nih.gov/30689296","citation_count":35,"is_preprint":false},{"pmid":"29602058","id":"PMC_29602058","title":"Cell mechanics of pollen tube growth.","date":"2018","source":"Current opinion in genetics & development","url":"https://pubmed.ncbi.nlm.nih.gov/29602058","citation_count":34,"is_preprint":false},{"pmid":"20298233","id":"PMC_20298233","title":"Female gametophyte-controlled pollen tube guidance.","date":"2010","source":"Biochemical Society transactions","url":"https://pubmed.ncbi.nlm.nih.gov/20298233","citation_count":34,"is_preprint":false},{"pmid":"27451100","id":"PMC_27451100","title":"Molecular Signaling Pathways Controlling Vascular Tube Morphogenesis and Pericyte-Induced Tube Maturation in 3D Extracellular Matrices.","date":"2016","source":"Advances in pharmacology (San Diego, Calif.)","url":"https://pubmed.ncbi.nlm.nih.gov/27451100","citation_count":34,"is_preprint":false},{"pmid":"27025884","id":"PMC_27025884","title":"Microtubules, polarity and vertebrate neural tube morphogenesis.","date":"2016","source":"Journal of anatomy","url":"https://pubmed.ncbi.nlm.nih.gov/27025884","citation_count":33,"is_preprint":false},{"pmid":"22689267","id":"PMC_22689267","title":"Neural tube defects by NUAK1 and NUAK2 double mutation.","date":"2012","source":"Developmental dynamics : an official publication of the American Association of Anatomists","url":"https://pubmed.ncbi.nlm.nih.gov/22689267","citation_count":32,"is_preprint":false},{"pmid":"31283415","id":"PMC_31283415","title":"Fallopian Tube Carcinoma.","date":"2019","source":"Journal of oncology practice","url":"https://pubmed.ncbi.nlm.nih.gov/31283415","citation_count":28,"is_preprint":false},{"pmid":"9587043","id":"PMC_9587043","title":"Neural tube defects, vitamins and homocysteine.","date":"1998","source":"European journal of pediatrics","url":"https://pubmed.ncbi.nlm.nih.gov/9587043","citation_count":27,"is_preprint":false},{"pmid":"9425355","id":"PMC_9425355","title":"Differentiation of the vertebrate neural tube.","date":"1997","source":"Current opinion in cell biology","url":"https://pubmed.ncbi.nlm.nih.gov/9425355","citation_count":27,"is_preprint":false},{"pmid":"24333598","id":"PMC_24333598","title":"Endothelial connexin32 enhances angiogenesis by positively regulating tube formation and cell migration.","date":"2013","source":"Experimental cell research","url":"https://pubmed.ncbi.nlm.nih.gov/24333598","citation_count":27,"is_preprint":false},{"pmid":"29712790","id":"PMC_29712790","title":"NMDA Receptor Signaling Is Important for Neural Tube Formation and for Preventing Antiepileptic Drug-Induced Neural Tube Defects.","date":"2018","source":"The Journal of neuroscience : the official journal of the Society for Neuroscience","url":"https://pubmed.ncbi.nlm.nih.gov/29712790","citation_count":27,"is_preprint":false},{"pmid":"30562244","id":"PMC_30562244","title":"New developments in tube shunt surgery.","date":"2019","source":"Current opinion in ophthalmology","url":"https://pubmed.ncbi.nlm.nih.gov/30562244","citation_count":26,"is_preprint":false},{"pmid":"34569598","id":"PMC_34569598","title":"TP53 loss initiates chromosomal instability in fallopian tube epithelial cells.","date":"2021","source":"Disease models & mechanisms","url":"https://pubmed.ncbi.nlm.nih.gov/34569598","citation_count":26,"is_preprint":false},{"pmid":"14624839","id":"PMC_14624839","title":"Tube morphogenesis: closure, but many openings remain.","date":"2003","source":"Trends in cell biology","url":"https://pubmed.ncbi.nlm.nih.gov/14624839","citation_count":26,"is_preprint":false},{"pmid":"29125517","id":"PMC_29125517","title":"Genetic epidemiology of neural tube defects.","date":"2017","source":"Journal of pediatric rehabilitation medicine","url":"https://pubmed.ncbi.nlm.nih.gov/29125517","citation_count":25,"is_preprint":false},{"pmid":"33193543","id":"PMC_33193543","title":"Mechanics of Pollen Tube Elongation: A Perspective.","date":"2020","source":"Frontiers in plant science","url":"https://pubmed.ncbi.nlm.nih.gov/33193543","citation_count":25,"is_preprint":false},{"pmid":"24662893","id":"PMC_24662893","title":"Tube fusion: making connections in branched tubular networks.","date":"2014","source":"Seminars in cell & developmental biology","url":"https://pubmed.ncbi.nlm.nih.gov/24662893","citation_count":24,"is_preprint":false},{"pmid":"14747189","id":"PMC_14747189","title":"Expression of fractalkine in the Fallopian tube and of CX3CR1 in sperm.","date":"2004","source":"Human reproduction (Oxford, England)","url":"https://pubmed.ncbi.nlm.nih.gov/14747189","citation_count":24,"is_preprint":false},{"pmid":"16661988","id":"PMC_16661988","title":"RNA, proteins and polyamines during tube growth in germinating apple pollen.","date":"1981","source":"Plant physiology","url":"https://pubmed.ncbi.nlm.nih.gov/16661988","citation_count":24,"is_preprint":false},{"pmid":"28246178","id":"PMC_28246178","title":"Signaling Networks in Epithelial Tube Formation.","date":"2017","source":"Cold Spring Harbor perspectives in biology","url":"https://pubmed.ncbi.nlm.nih.gov/28246178","citation_count":23,"is_preprint":false},{"pmid":"23277919","id":"PMC_23277919","title":"Apicobasal polarity and neural tube closure.","date":"2012","source":"Development, growth & differentiation","url":"https://pubmed.ncbi.nlm.nih.gov/23277919","citation_count":23,"is_preprint":false},{"pmid":"19186242","id":"PMC_19186242","title":"Modeling neural tube defects in the mouse.","date":"2008","source":"Current topics in developmental biology","url":"https://pubmed.ncbi.nlm.nih.gov/19186242","citation_count":23,"is_preprint":false},{"pmid":"27827820","id":"PMC_27827820","title":"Nodal and FGF coordinate ascidian neural tube morphogenesis.","date":"2016","source":"Development (Cambridge, England)","url":"https://pubmed.ncbi.nlm.nih.gov/27827820","citation_count":23,"is_preprint":false},{"pmid":"18707228","id":"PMC_18707228","title":"Tube formation in Drosophila egg chambers.","date":"2008","source":"Tissue engineering. Part A","url":"https://pubmed.ncbi.nlm.nih.gov/18707228","citation_count":22,"is_preprint":false},{"pmid":"29478513","id":"PMC_29478513","title":"Blood Glucose Determination: Effect of Tube Additives.","date":"2018","source":"Advances in clinical chemistry","url":"https://pubmed.ncbi.nlm.nih.gov/29478513","citation_count":22,"is_preprint":false},{"pmid":"27172951","id":"PMC_27172951","title":"Tube-Forming Assays.","date":"2016","source":"Methods in molecular biology (Clifton, N.J.)","url":"https://pubmed.ncbi.nlm.nih.gov/27172951","citation_count":21,"is_preprint":false},{"pmid":"26349489","id":"PMC_26349489","title":"Nutri-epigenomic Studies Related to Neural Tube Defects: Does Folate Affect Neural Tube Closure Via Changes in DNA Methylation?","date":"2015","source":"Mini reviews in medicinal chemistry","url":"https://pubmed.ncbi.nlm.nih.gov/26349489","citation_count":21,"is_preprint":false},{"pmid":"21471152","id":"PMC_21471152","title":"MIM regulates vertebrate neural tube closure.","date":"2011","source":"Development (Cambridge, England)","url":"https://pubmed.ncbi.nlm.nih.gov/21471152","citation_count":21,"is_preprint":false},{"pmid":"32926990","id":"PMC_32926990","title":"An ontology for developmental processes and toxicities of neural tube closure.","date":"2020","source":"Reproductive toxicology (Elmsford, N.Y.)","url":"https://pubmed.ncbi.nlm.nih.gov/32926990","citation_count":21,"is_preprint":false},{"pmid":"28837393","id":"PMC_28837393","title":"Claudins in morphogenesis: Forming an epithelial tube.","date":"2017","source":"Tissue barriers","url":"https://pubmed.ncbi.nlm.nih.gov/28837393","citation_count":19,"is_preprint":false},{"pmid":"10609896","id":"PMC_10609896","title":"Folate status and neural tube defects.","date":"1999","source":"BioFactors (Oxford, England)","url":"https://pubmed.ncbi.nlm.nih.gov/10609896","citation_count":19,"is_preprint":false},{"pmid":"31750424","id":"PMC_31750424","title":"Advances in Eustachian tube function testing.","date":"2019","source":"World journal of otorhinolaryngology - head and neck surgery","url":"https://pubmed.ncbi.nlm.nih.gov/31750424","citation_count":18,"is_preprint":false},{"pmid":"33687331","id":"PMC_33687331","title":"A polarity pathway for exocyst-dependent intracellular tube extension.","date":"2021","source":"eLife","url":"https://pubmed.ncbi.nlm.nih.gov/33687331","citation_count":18,"is_preprint":false},{"pmid":"11499052","id":"PMC_11499052","title":"Screening for neural tube defects.","date":"2001","source":"Clinics in perinatology","url":"https://pubmed.ncbi.nlm.nih.gov/11499052","citation_count":18,"is_preprint":false},{"pmid":"22707217","id":"PMC_22707217","title":"Imaging of primary fallopian tube carcinoma.","date":"2013","source":"Abdominal imaging","url":"https://pubmed.ncbi.nlm.nih.gov/22707217","citation_count":17,"is_preprint":false},{"pmid":"14692594","id":"PMC_14692594","title":"Is there more to folates than neural-tube defects?","date":"2003","source":"The Proceedings of the Nutrition Society","url":"https://pubmed.ncbi.nlm.nih.gov/14692594","citation_count":17,"is_preprint":false},{"pmid":"10734213","id":"PMC_10734213","title":"One tube mutation detection using sensitive fluorescent dyeing of MutS protected DNA.","date":"2000","source":"Nucleic acids research","url":"https://pubmed.ncbi.nlm.nih.gov/10734213","citation_count":17,"is_preprint":false}],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":38640,"output_tokens":372,"usd":0.06075,"stage1_stop_reason":"end_turn"},"stage2":{"model":"","input_tokens":0,"output_tokens":0,"usd":0.0},"total_usd":0.06075,"stage1_batch_id":"msgbatch_017qqVz33Ga63SCDwzb35XPb","stage2_batch_id":"msgbatch_01Scr2Ei9x4HJMiRGxwrmvLK","note":"batch pricing = 50% of standard"},"stage1_raw":"Looking at the corpus, I need to identify papers that are actually about the TUBE1 gene (also known as TUBE, dJ142L7.2, FLJ22589 - which encodes epsilon-tubulin in humans/mammals).\n\nScanning the corpus carefully:\n\n- Most papers are about anatomical tubes (neural tubes, pollen tubes, fallopian tubes, tracheal tubes, etc.) - these are NOT about the TUBE1 gene\n- Paper [20] (PMID:10330490) describes \"Tube\" in Drosophila as part of the Toll/Dorsal signaling pathway - this is a different protein (Drosophila \"Tube\" is a death domain-containing signaling protein, not epsilon-tubulin)\n- None of the papers appear to describe TUBE1/epsilon-tubulin (a centriole/centriolar satellite component involved in centriole duplication)\n\nThe Drosophila \"Tube\" in paper [20] is not an ortholog of human TUBE1 (epsilon-tubulin). Human TUBE1 encodes epsilon-tubulin, a tubulin family member involved in centriole function. The Drosophila \"Tube\" signaling protein is a fundamentally different protein involved in the Toll pathway - this is a symbol collision, not an ortholog.\n\nNone of the 100 papers describe the canonical human TUBE1 (epsilon-tubulin) gene with mechanistic experiments.\n\n```json\n{\n  \"discoveries\": [],\n  \"current_model\": \"No mechanistic findings in the available literature.\"\n}\n```","stage2_raw":"","audit_flag":null,"evaluation":null}