Affinage

TRIM67

Tripartite motif-containing protein 67 · UniProt Q6ZTA4

Length
783 aa
Mass
83.8 kDa
Annotated
2026-06-10
51 papers in source corpus 18 papers cited in narrative 18 extracted findings
Cross-family judge faithfulness: 5/6 claims corpus-supported (83%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

TRIM67 is a brain-enriched RING-domain E3 ubiquitin ligase that operates both as a substrate-degrading enzyme controlling cell-fate signaling and as a scaffold guiding neuronal morphogenesis (PMID:31239268, PMID:38434968, PMID:41085995). As an E3 ligase, it directs RING-dependent ubiquitination of multiple substrates to gate distinct pathways: it degrades DLK1 to relieve inhibition of Notch1 (PMID:38434968), degrades ARSD to inactivate β-catenin and suppress glycolysis (PMID:41396160), degrades NFS1 to constrain colorectal cancer cell proliferation and stemness (PMID:42069097), and degrades ACSL4 and VDAC1 to suppress ferroptosis in neuronal ischemia–reperfusion models (PMID:42136259, PMID:41587377). In tumor-suppressive contexts TRIM67 acts non-degradatively as well, binding the p53 C-terminus to antagonize MDM2-mediated p53 degradation within a p53-driven self-amplifying loop (PMID:31239268), and competitively sequestering β-TrCP to spare IκBα from K48-linked degradation and dampen NF-κB activation (PMID:35273593, PMID:37248543). Its catalytic output is itself regulated by competitive binding: PCK2 blocks TRIM67-mediated SMAD3 ubiquitination to license TGF-β/SMAD3-driven EMT (PMID:40081967). In developing neurons, TRIM67 functions alongside its paralog TRIM9 and the netrin receptor DCC, and requires its interaction with Coro1A for netrin-dependent axon turning, branching, and corpus callosum formation (PMID:29911180, PMID:41085995); deletion in mice produces hypotrophy of forebrain structures and thinned commissures (PMID:29911180). At the axonal periphery it controls plasma membrane expansion by limiting incorporation of the SNARE SNAP47 into SNARE complexes to favor full-vesicle fusion (PMID:33567284).

Mechanistic history

Synthesis pass · year-by-year structured walk · 16 steps
  1. 2012 Medium

    Established TRIM67 as a functional E3 ligase by identifying its first substrate and linking its activity to Ras signaling and neurite outgrowth.

    Evidence Co-IP and ectopic expression/knockdown with 80K-H in N1E-115 neuroblastoma cells

    PMID:22337885

    Open questions at the time
    • No in vitro reconstitution or RING-domain mutagenesis to prove direct catalysis
    • Connection to endogenous Ras pathway output indirect
  2. 2018 Medium

    Defined TRIM67 as necessary for brain development and placed it in a neuronal complex with its paralog TRIM9 and netrin receptor DCC.

    Evidence Reciprocal Co-IP plus Trim67 knockout mouse neuroanatomy and behavior

    PMID:29911180

    Open questions at the time
    • Molecular function within the TRIM9/DCC complex not resolved
    • Whether anatomical phenotypes require ligase activity unknown
  3. 2019 High

    Resolved a tumor-suppressive mechanism whereby TRIM67 stabilizes p53 by antagonizing MDM2, and showed reciprocal transcriptional control by p53.

    Evidence Co-IP, ubiquitination assay, ChIP, RNA-seq and KO mouse colorectal tumor models

    PMID:31239268

    Open questions at the time
    • Whether p53 stabilization is catalytic or purely competitive sequestration not fully separated
    • Tissue specificity of the loop beyond colorectum unaddressed
  4. 2020 Medium

    Mapped the TRIM67 neuronal interactome and tied it to growth-cone filopodia and axon branching, expanding its scaffolding role at the axonal periphery.

    Evidence BioID/MS with Co-IP validation, TIRF imaging, and RNAi in cortical neurons

    PMID:33378226

    Open questions at the time
    • Which interactors are ubiquitination substrates versus scaffolds unclear
    • Direct vs proximity-only associations not all distinguished
  5. 2021 High

    Identified a membrane-trafficking function: TRIM67 controls exocytic mode and plasma membrane expansion by restricting SNAP47 entry into SNARE complexes.

    Evidence Single-event TIRF imaging, RNAi, SNARE Co-IP and simulation in cortical neurons

    PMID:33567284

    Open questions at the time
    • Whether SNAP47 restriction is ubiquitination-dependent not established
    • Link between this trafficking role and substrate-degrading roles unknown
  6. 2022 Medium

    Extended the non-degradative mechanism to NF-κB control, showing TRIM67 competitively binds β-TrCP to protect IκBα.

    Evidence Co-IP, NF-κB luciferase reporter and knockdown in MEFs

    PMID:35273593

    Open questions at the time
    • No in vitro reconstitution of competitive binding
    • Stoichiometry of β-TrCP sequestration not quantified
  7. 2023 Medium

    Refined the IκBα mechanism by showing TRIM67 shifts IκBα ubiquitin linkage from K48 to K63 to stabilize it after cerebral ischemia.

    Evidence Linkage-specific ubiquitination assays and Co-IP in MCAO/R mice and OGD/R microglia

    PMID:37248543

    Open questions at the time
    • Whether TRIM67 directly catalyzes the K63 chains or recruits another ligase unclear
    • Reconciliation with the competitive-sequestration model not addressed
  8. 2024 Medium

    Demonstrated RING-dependent degradation of DLK1 as a route to Notch activation in lung cancer, formally implicating the catalytic domain.

    Evidence Co-IP, ubiquitination assay with RING mutant, Notch reporter in NSCLC lines

    PMID:38434968

    Open questions at the time
    • Direct ubiquitin transfer to DLK1 not shown in a purified system
    • Context-dependence (oncogenic here vs tumor-suppressive elsewhere) unexplained
  9. 2024 Medium

    Added ENAH as a TRIM67 binding partner upstream of apoptosis and autophagy in lung cancer.

    Evidence Co-IP, GST pull-down, siRNA and rescue in lung cancer cells

    PMID:38477606

    Open questions at the time
    • Whether ENAH is a degradation substrate not tested
    • Mechanism linking ENAH to autophagy not defined
  10. 2025 High

    Established the Coro1A–TRIM67 interaction as functionally required for netrin-mediated neuronal morphogenesis using a binding-deficient mutant.

    Evidence Co-IP, structure-function mutant rescue, and Trim67/Coro1A knockout mice with axon turning/branching assays

    PMID:41085995

    Open questions at the time
    • Whether Coro1A is ubiquitinated by TRIM67 unknown
    • Molecular consequence of the interaction at the cytoskeleton unresolved
  11. 2025 Medium

    Showed RING-dependent ARSD degradation links TRIM67 to β-catenin inactivation, glycolytic suppression, and temozolomide sensitization in glioblastoma.

    Evidence Co-IP, ubiquitination assay, rescue and xenograft models

    PMID:41396160

    Open questions at the time
    • Direct ubiquitin transfer not shown in purified system
    • How ARSD couples to β-catenin not mechanistically detailed
  12. 2025 Medium

    Defined K63-linked ubiquitination of VDAC1 by TRIM67 as a ferroptosis-suppressing, cerebroprotective axis induced by propofol.

    Evidence Linkage-specific ubiquitination assay, Co-IP, OGD/R cells and MCAO rat model

    PMID:42136259

    Open questions at the time
    • K63 chains canonically non-degradative yet degradation reported — mechanism unclear
    • Direct catalysis not reconstituted
  13. 2025 Medium

    Identified PCK2 as a competitive inhibitor of TRIM67-mediated SMAD3 ubiquitination, revealing regulation of TRIM67 catalytic output that gates TGF-β/SMAD3 EMT.

    Evidence Co-IP, ubiquitination assay, competitive binding and SMAD3 rescue in TNBC cells

    PMID:40081967

    Open questions at the time
    • Binding interface for PCK2 competition not mapped
    • Whether SMAD3 is a direct catalytic substrate not shown in purified system
  14. 2026 Medium

    Showed TRIM67 degrades NFS1 to suppress colorectal cancer proliferation and stemness, reinforcing its tumor-suppressive substrate repertoire.

    Evidence Co-IP, ubiquitination and CHX chase assays, rescue and xenograft

    PMID:42069097

    Open questions at the time
    • RING dependence not explicitly tested
    • Downstream effector of NFS1 loss undefined
  15. 2026 Medium

    Demonstrated TRIM67 degrades ACSL4 to limit neuronal ferroptosis, apoptosis and inflammation, with remimazolam acting upstream.

    Evidence Co-IP, ubiquitination assay, OGD/R cells and MCAO rat model

    PMID:41587377

    Open questions at the time
    • Direct catalysis not reconstituted
    • Relationship to the VDAC1 ferroptosis axis not integrated
  16. 2026 Medium

    Placed TRIM67 in a metastatic regulatory circuit where miR-8085 suppresses it, derepressing ELK1 to drive NSCLC brain metastasis.

    Evidence Luciferase miRNA target validation, ELK1 ubiquitination assay, EV transfer and in vivo models

    PMID:42226139

    Open questions at the time
    • Direct ELK1 ubiquitination by TRIM67 not shown in purified system
    • Generalizability beyond brain-metastatic NSCLC unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • How TRIM67 selects among its many reported substrates in a context-specific manner, and what reconciles its opposing tumor-suppressive and oncogenic outputs, remains unresolved.
  • No purified-system reconstitution of catalysis for most substrates
  • No structural basis for substrate or competitor selection
  • Tissue-specific switch between tumor-suppressor and oncogenic roles undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 6 GO:0016740 transferase activity 3 GO:0098772 molecular function regulator activity 2
Localization
GO:0005856 cytoskeleton 2 GO:0005886 plasma membrane 1
Pathway
R-HSA-162582 Signal Transduction 4 R-HSA-392499 Metabolism of proteins 4 R-HSA-5357801 Programmed Cell Death 3 R-HSA-1266738 Developmental Biology 2 R-HSA-168256 Immune System 2 R-HSA-5653656 Vesicle-mediated transport 1
Partners
BTRCCORO1ADCCENAHIKBAP53SMAD3TRIM9

Evidence

Reading pass · 18 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2012 TRIM67 interacts with PRG-1 and 80K-H (a Ras-mediated signaling pathway component); ectopic TRIM67 expression causes ubiquitin-dependent degradation of endogenous 80K-H, attenuates cell proliferation, and enhances neuritogenesis in N1E-115 neuroblastoma cells, suggesting TRIM67 negatively regulates Ras signaling via 80K-H degradation. Co-immunoprecipitation, ectopic overexpression, knockdown of 80K-H, morphological assays in neuroblastoma cells The Journal of biological chemistry Medium 22337885
2018 TRIM67 interacts with its closest paralog TRIM9 and with the netrin receptor DCC; deletion of murine Trim67 results in hypotrophy of specific brain regions (hippocampus, striatum, amygdala, thalamus) and thinning of forebrain commissures, demonstrating a necessary role in brain development. Co-immunoprecipitation, Trim67 knockout mouse model, neuroanatomical analysis, behavioral testing eNeuro Medium 29911180
2019 TRIM67 directly interacts with the C-terminus of p53, inhibiting MDM2-mediated ubiquitination and degradation of p53; TRIM67 is also a transcriptional target of p53, forming a TRIM67/p53 self-amplifying loop that boosts p53-induced cell growth inhibition and apoptosis; Trim67 knockout in mice accelerates colorectal tumor formation and dampens p53 responses. Co-immunoprecipitation, ubiquitination assay, RNA sequencing, Trim67 knockout mouse models, chromatin immunoprecipitation, in vitro and in vivo rescue experiments Cancer research High 31239268
2020 Proximity-dependent biotin identification (BioID) in developing cortical neurons defined the TRIM67 neuronal interactome; validated interaction partners include Myo16, Coro1A, MAP1B, ExoC1, GRIP1, PRG-1, and KIF1A; TIRF microscopy demonstrated dynamic colocalization of TRIM67 with these candidates at the axonal periphery including filopodial tips; Myo16 knockdown altered growth cone filopodia density and axonal branching in a TRIM9- and netrin-1-dependent manner. BioID proximity labeling, mass spectrometry, co-immunoprecipitation validation, TIRF microscopy, RNAi knockdown in cortical neurons Molecular biology of the cell Medium 33378226
2020 TRIM67 inhibits colorectal cancer cell proliferation and metastasis by negatively regulating MAPK11; RNA sequencing identified MAPK11 as a downstream target of TRIM67, and reversing MAPK11 expression rescued the anti-proliferative and anti-metastatic effects of TRIM67. RNA sequencing, TRIM67 overexpression/knockdown in CRC cells, MAPK11 rescue experiments, CCK-8, colony formation, transwell assays Journal of Cancer Low 32922543
2021 TRIM67 promotes full-vesicle fusion (FVF)-like exocytic mode in developing cortical neurons, in part by limiting incorporation of the Qb/Qc SNARE SNAP47 into SNARE complexes, thereby controlling plasma membrane expansion during neuronal morphogenesis. TIRF microscopy of individual exocytic events, classification algorithms, RNAi knockdown of TRIM67, co-immunoprecipitation to assess SNARE complex composition, simulation modeling Cell reports High 33567284
2022 TRIM67 negatively regulates TNFα-triggered NF-κB activation by competitively binding β-TrCP (beta-transducin repeat-containing protein), thereby preventing β-TrCP-mediated K48-linked ubiquitination and degradation of IκBα and sustaining IκBα stability. Ectopic expression and knockdown in MEFs, NF-κB luciferase reporter assay, Co-immunoprecipitation to demonstrate TRIM67–β-TrCP and TRIM67–IκBα interactions, cytokine expression assays Frontiers in immunology Medium 35273593
2023 TRIM67 binds IκBα and modulates its ubiquitination: it reduces K48-linked (degradative) ubiquitination and increases K63-linked ubiquitination of IκBα, thereby stabilizing IκBα and inhibiting NF-κB activity after cerebral ischemia–reperfusion injury. Co-immunoprecipitation, ubiquitination assays (K48 vs K63 linkage-specific), TRIM67 overexpression in MCAO/R mouse model and OGD/R microglia, infarct size measurement Cell & bioscience Medium 37248543
2024 TRIM67 ubiquitinates DLK1 via its RING domain, targeting DLK1 for degradation; because DLK1 normally inhibits Notch1 receptor activation, TRIM67-mediated DLK1 ubiquitination results in Notch pathway activation and promotes NSCLC cell invasion, migration, and proliferation. Co-immunoprecipitation, ubiquitination assay with RING domain mutant, TRIM67 and DLK1 overexpression/knockdown in NSCLC cell lines, Notch pathway reporter assays Journal of Cancer Medium 38434968
2025 TRIM67 promotes ubiquitinated degradation of ARSD through its RING domain; TRIM67 overexpression suppresses GBM cell glycolysis and increases temozolomide sensitivity by decreasing ARSD expression, which inactivates the β-catenin pathway. Co-immunoprecipitation, ubiquitination assay, TRIM67 overexpression/knockdown, rescue with ARSD overexpression, xenograft mouse model FASEB journal Medium 41396160
2025 Coro1A physically interacts with TRIM67; a Coro1A mutant deficient in TRIM67 binding cannot rescue loss-of-Coro1A phenotypes (netrin-dependent axon turning, branching, corpus callosum development), establishing that the Coro1A–TRIM67 interaction is required for netrin-mediated neuronal morphogenesis. Co-immunoprecipitation, Coro1A binding-deficient mutant rescue experiments in cortical neurons, axon turning and branching assays, Trim67/Coro1A knockout mice The Journal of cell biology High 41085995
2025 TRIM67 promotes ubiquitination and proteasomal degradation of VDAC1 through K63-linked polyubiquitination; propofol upregulates TRIM67 expression, leading to VDAC1 degradation, suppression of ferroptosis, and cerebroprotection against ischemia–reperfusion injury. Co-immunoprecipitation, ubiquitination assay (K63-linkage specific), TRIM67 knockdown and overexpression, OGD/R cell model and MCAO rat model Chemical biology & drug design Medium 42136259
2026 TRIM67 directly interacts with NFS1 and promotes its ubiquitination and proteasomal degradation; TRIM67 overexpression suppresses CRC cell proliferation, migration, and stemness, and these effects are rescued by concurrent NFS1 overexpression. Co-immunoprecipitation, ubiquitination assay, cycloheximide chase, TRIM67 overexpression/knockdown, rescue experiments, xenograft model Cellular signalling Medium 42069097
2026 TRIM67 directly interacts with ACSL4 and promotes its ubiquitination and degradation; TRIM67-mediated ACSL4 downregulation alleviates OGD/R-induced neuronal apoptosis, inflammation, and ferroptosis; remimazolam enhances TRIM67 expression to achieve these neuroprotective effects. Co-immunoprecipitation, ubiquitination assay, TRIM67 knockdown and overexpression, OGD/R cell model and MCAO rat model, Western blot Journal of biochemical and molecular toxicology Medium 41587377
2025 PCK2 (PEPCK-M) competitively binds TRIM67 to block TRIM67-mediated ubiquitination of SMAD3, thereby stabilizing SMAD3 protein, promoting its nuclear translocation and autoregulation, and activating TGF-β/SMAD3-driven EMT in triple-negative breast cancer. Co-immunoprecipitation, ubiquitination assay, PCK2 knockdown and overexpression, SMAD3 knockdown rescue experiments, Western blot for phospho-SMAD3 Cancer biology & therapy Medium 40081967
2024 TRIM67 interacts with ENAH protein (as shown by Co-IP and GST pull-down); TRIM67 knockdown promotes apoptosis and autophagy in lung cancer cells, and ENAH overexpression reverses these effects, placing TRIM67–ENAH interaction upstream of apoptosis/autophagy regulation. Co-immunoprecipitation, GST pull-down, siRNA knockdown, immunofluorescence localization, flow cytometry, Western blot, TEM General physiology and biophysics Medium 38477606
2023 TRIM67 is abundantly expressed in the mitral cell layer of the olfactory bulb; genetic deletion of TRIM67 in mice leads to excessive proliferation of mitral cells and defects in synaptic development, resulting in reduced olfactory function; TRIM67 may regulate mitral cells via the Semaphorin 7A/Plexin C1 (Sema7A/PlxnC1) signaling pathway. Trim67 knockout mouse model, immunohistochemistry, neuroanatomical analysis, olfactory behavioral tests, Western blot/pathway analysis International journal of molecular sciences Low 37686246
2026 miR-8085 (delivered via astrocyte-derived extracellular vesicles) targets and downregulates TRIM67 in NSCLC tumor cells; loss of TRIM67 stabilizes the transcription factor ELK1 by reducing its ubiquitin-mediated degradation, thereby promoting tumor stemness and brain metastasis. miRNA target validation (luciferase reporter), TRIM67 knockdown/overexpression, ubiquitination assay for ELK1, extracellular vesicle isolation and transfer assays, in vivo models Cellular & molecular biology letters Medium 42226139

Source papers

Stage 0 corpus · 51 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2019 Differential regulation of TNL-mediated immune signaling by redundant helper CNLs. The New phytologist 151 30585636
2021 Pathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity. Nature communications 137 34099661
2019 An EDS1-SAG101 Complex Is Essential for TNL-Mediated Immunity in Nicotiana benthamiana. The Plant cell 105 31266900
2019 TRIM67 Activates p53 to Suppress Colorectal Cancer Initiation and Progression. Cancer research 88 31239268
2011 The Ma gene for complete-spectrum resistance to Meloidogyne species in Prunus is a TNL with a huge repeated C-terminal post-LRR region. Plant physiology 66 21482634
2018 Mammalian TRIM67 Functions in Brain Development and Behavior. eNeuro 52 29911180
2016 Temperature-dependent autoimmunity mediated by chs1 requires its neighboring TNL gene SOC3. The New phytologist 52 27699788
2015 Autoimmunity conferred by chs3-2D relies on CSA1, its adjacent TNL-encoding neighbour. Scientific reports 46 25740259
2019 Disruption of the MAMP-Induced MEKK1-MKK1/MKK2-MPK4 Pathway Activates the TNL Immune Receptor SMN1/RPS6. Plant & cell physiology 45 30590768
2012 TRIM67 protein negatively regulates Ras activity through degradation of 80K-H and induces neuritogenesis. The Journal of biological chemistry 44 22337885
2019 TRIM9 and TRIM67 Are New Targets in Paraneoplastic Cerebellar Degeneration. Cerebellum (London, England) 42 30350014
2022 Exosome-Derived Circ_0094343 Promotes Chemosensitivity of Colorectal Cancer Cells by Regulating Glycolysis via the miR-766-5p/TRIM67 Axis. Contrast media & molecular imaging 41 35854778
2022 TRIM67 Suppresses TNFalpha-Triggered NF-kB Activation by Competitively Binding Beta-TrCP to IkBa. Frontiers in immunology 39 35273593
2020 The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Molecular biology of the cell 39 33378226
2020 TRIM67 Promotes the Proliferation, Migration, and Invasion of Non-Small-Cell Lung Cancer by Positively Regulating the Notch Pathway. Journal of Cancer 34 31956370
2022 EDS1 complexes are not required for PRR responses and execute TNL-ETI from the nucleus in Nicotiana benthamiana. The New phytologist 30 36151929
2020 TRIM67 inhibits tumor proliferation and metastasis by mediating MAPK11 in Colorectal Cancer. Journal of Cancer 26 32922543
2016 TNL genes in peach: insights into the post-LRR domain. BMC genomics 24 27129402
2023 TRIM67 alleviates cerebral ischemia‒reperfusion injury by protecting neurons and inhibiting neuroinflammation via targeting IκBα for K63-linked polyubiquitination. Cell & bioscience 23 37248543
2021 The truncated TNL receptor TN2-mediated immune responses require ADR1 function. The Plant journal : for cell and molecular biology 23 34396631
2024 Cytoplasmic calcium influx mediated by plant MLKLs confers TNL-triggered immunity. Cell host & microbe 22 38513655
2021 TRIM67 regulates exocytic mode and neuronal morphogenesis via SNAP47. Cell reports 22 33567284
2022 Loss of TRIM67 Attenuates the Progress of Obesity-Induced Non-Alcoholic Fatty Liver Disease. International journal of molecular sciences 21 35806477
2017 The TNL gene Rdr1 confers broad-spectrum resistance to Diplocarpon rosae. Molecular plant pathology 18 28779550
2017 Comparative Genomics of Non-TNL Disease Resistance Genes from Six Plant Species. Genes 17 28973974
2019 TRIM67 promotes NF‑κB pathway and cell apoptosis in GA‑13315‑treated lung cancer cells. Molecular medicine reports 14 31322254
2024 TRIM67 Promotes Non-Small Cell Lung Cancer Development by Positively Regulating the Notch Pathway through DLK1 Ubiquitination. Journal of Cancer 13 38434968
2025 Deciphering Plant NLR Genomic Evolution: Synteny-Informed Classification Unveils Insights into TNL Gene Loss. Molecular biology and evolution 11 39835721
2025 PCK2 promotes invasion and epithelial-to-mesenchymal transition in triple-negative breast cancer by promoting TGF-β/SMAD3 signaling through inhibiting TRIM67-mediated SMAD3 ubiquitination. Cancer biology & therapy 11 40081967
2018 Evolutionary Divergence of TNL Disease-Resistant Proteins in Soybean (Glycine max) and Common Bean (Phaseolus vulgaris). Biochemical genetics 11 29500532
2012 Evolution of the Rdr1 TNL-cluster in roses and other Rosaceous species. BMC genomics 11 22905676
2024 Recognition of a salivary effector by the TNL protein RCSP promotes effector-triggered immunity and systemic resistance in Nicotiana benthamiana. Journal of integrative plant biology 10 39474762
2023 Detection of High-Risk Paraneoplastic Antibodies against TRIM9 and TRIM67 Proteins. Annals of neurology 10 37632288
2022 Role of Ultrasound Imaging in the Prediction of TRIM67 in Brain Metastases From Breast Cancer. Frontiers in neurology 10 35795796
2022 Ameliorating Effects of TRIM67 against Intestinal Inflammation and Barrier Dysfunction Induced by High Fat Diet in Obese Mice. International journal of molecular sciences 9 35887011
2002 Cloning and regulation of the promoter of pseudorabies virus (TNL strain) glycoprotein E gene. Virus genes 9 12086144
2024 Dandouchi Polypeptide Alleviates Depressive-like Behavior and Promotes Hippocampal Neurogenesis by Activating the TRIM67/NF-κB Pathway in CUMS-Induced Mice. Journal of agricultural and food chemistry 4 39039032
2023 TRIM67 Implicates in Regulating the Homeostasis and Synaptic Development of Mitral Cells in the Olfactory Bulb. International journal of molecular sciences 3 37686246
2022 The Rm1 and Rm2 Resistance Genes to Green Peach Aphid (Myzus persicae) Encode the Same TNL Proteins in Peach (Prunus persica L.). Genes 3 36011400
2025 Coro1A and TRIM67 collaborate in netrin-dependent neuronal morphogenesis. The Journal of cell biology 2 41085995
2024 TRIM67 interacts with ENAH to regulate the apoptosis and autophagy of lung cancer cells. General physiology and biophysics 2 38477606
2025 NbWRKY57 activates helper nucleotide-binding leucine-rich repeat receptor transcription to promote TNL-mediated effector-triggered immunity in Nicotiana benthamiana. Plant physiology 1 41118522
1980 [Auxotrophic mutations formed on the incorporation into the E. coli C600 chromosome of transposon Tnl that determines ampicillin resistance]. Antibiotiki 1 6252827
2026 Remimazolam Inhibits Neuronal Apoptosis, Inflammation, and Ferroptosis in Cerebral Infarction via Promoting TRIM67-Mediated Degradation of ACSL4. Journal of biochemical and molecular toxicology 0 41587377
2026 Dual regulation of NFS1 by TRIM67-mediated degradation and CEBPA-driven transcription modulates colorectal cancer progression. Cellular signalling 0 42069097
2026 Propofol Exerts Cerebroprotective Effects Against Cerebral Infarction by Up-Regulating TRIM67 to Mediate VDAC1 Ubiquitination and Degradation. Chemical biology & drug design 0 42136259
2026 Lactate-activated astrocytes promote NSCLC brain metastasis through extracellular vesicle-mediated miR-8085/TRIM67/ELK1 signaling axis. Cellular & molecular biology letters 0 42226139
2025 Coro1A and TRIM67 collaborate in netrin-dependent neuronal morphogenesis. bioRxiv : the preprint server for biology 0 40166342
2025 The Impact of TRIM67 Knockout on Early Intestinal Antimicrobial Capacity in Mice Infected with Salmonella enterica serovar Typhimurium ATCC 14028. Microorganisms 0 40572155
2025 Effect of TRIM67 knockout on inflammation and macrophage survival in Salmonella Typhimurium-infected mice. Archives of microbiology 0 40824551
2025 TRIM67 Suppresses Glioblastoma Glycolysis and Increases Temozolomide Sensitivity by Promoting ARSD Ubiquitinated Degradation to Inactivate the β-Catenin Pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 0 41396160

Missed literature

Know a paper Affinage missed for TRIM67? Flag it for the maintainers and the community.

No submissions yet.