Affinage

TRIM24

Transcription intermediary factor 1-alpha · UniProt O15164

Length
1050 aa
Mass
116.8 kDa
Annotated
2026-06-10
100 papers in source corpus 35 papers cited in narrative 35 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

TRIM24 (TIF1α) is a chromatin-associated transcriptional co-regulator and RING-type E3-ubiquitin ligase that couples histone-mark recognition to transcription factor activity and protein turnover (PMID:7744009, PMID:21164480). It originated as a nuclear receptor co-regulator, binding the AF-2 activation domain of ligand-activated receptors including RXR, RAR, ER, TR and VDR in a ligand-dependent manner (PMID:7744009, PMID:9115274), and it engages chromatin through a tandem PHD-bromodomain that functions as a single reader unit simultaneously recognizing unmodified H3K4 (H3K4me0) and acetylated H3K23 (H3K23ac) on the same histone tail (PMID:21164480). This dual-mark recognition directs TRIM24 to specific loci, where H3K23 acetylation by KAT6A recruits it to activate PIK3CA and enhance PI3K/Akt signaling, and where it stabilizes STAT3-chromatin interactions downstream of EGFR (PMID:29021135, PMID:29129908). As an E3 ligase, TRIM24 ubiquitylates and degrades p53, and is itself transcriptionally induced by p53 and destabilized by ATM-mediated phosphorylation at S768 upon DNA damage, forming an MDM2-like autoregulatory feedback loop that terminates the damage response (PMID:19556538, PMID:24820418); genome-wide it restricts p53 to closed chromatin and limits p53-driven chromatin opening in an H3K4-methylation-dependent manner (PMID:37386214). Beyond p53, its ligase activity directs K48-linked ubiquitination of NLRP3 to suppress pyroptosis, K63-linked ubiquitination of TRAF3 at mitochondria to amplify antiviral IFN-I signaling, and CBP ubiquitination to promote Stat6 acetylation and restrain macrophage M2 polarization (PMID:33724611, PMID:32324863, PMID:31554795). TRIM24 assembles into TIF1-subfamily complexes with TRIM33 and TRIM28, and its own stability is governed by SPOP-mediated degradation antagonized by TRIM28 and USP7 (PMID:21531907, PMID:27238081, PMID:30479348, PMID:38129408). In the liver, TRIM24 acts as a tumor suppressor by repressing RARα-mediated transcription and the IFN/STAT pathway, with its loss driving hepatocellular carcinoma, steatosis and fibrosis (PMID:18026104, PMID:21768647, PMID:25281858), whereas in prostate cancer, glioblastoma, breast and leukemia it functions as an oncogenic dependency through AR, PI3K/Akt, STAT3 and Met co-activation, validated as a degradable target by PROTAC chemistry (PMID:27238081, PMID:34508101, PMID:29507391).

Mechanistic history

Synthesis pass · year-by-year structured walk · 33 steps
  1. 1995 High

    Established TRIM24's founding identity as a nuclear receptor interactor, defining it as a ligand-dependent partner of the receptor AF-2 domain.

    Evidence Yeast two-hybrid, in vitro and mammalian co-transfection across RXR, RAR, ER, TR, VDR

    PMID:7744009

    Open questions at the time
    • Did not establish whether interaction activates or represses receptor transcription
    • No structural basis for AF-2 recognition
    • No genome-wide target loci defined
  2. 1997 High

    Mapped the human receptor-interaction determinant, showing a discrete 26-residue region mediates hormone-dependent, AF-2-specific ER binding.

    Evidence In vitro pull-down with ER AF-2 point mutagenesis

    PMID:9115274

    Open questions at the time
    • Functional consequence for endogenous ER targets not shown
    • Selectivity mechanism across receptors unexplained
  3. 1996 High

    Linked TRIM24 to chromatin silencing machinery via HP1 interaction, but a 1999 negative result showed endogenous TRIM24 does not associate with HP1, attributing its silencing instead to histone deacetylation.

    Evidence Yeast two-hybrid (1996); reciprocal co-IP of nuclear extracts, in vitro kinase assay, TSA treatment (1999)

    PMID:10562550 PMID:8978696

    Open questions at the time
    • HDAC that mediates silencing not identified
    • In vitro HP1 phosphorylation lacks in vivo significance
  4. 2007 High

    Defined TRIM24 as a liver-specific tumor suppressor acting through RARα antagonism, answering whether its receptor coupling has a physiological tumor-relevant output.

    Evidence Trim24 knockout mice with Trim24-/- x Rara+/- genetic epistasis and RA pathway readouts

    PMID:18026104

    Open questions at the time
    • Molecular basis of RARα repression not resolved
    • Tissue-specificity of tumor suppression unexplained
  5. 2009 High

    Identified TRIM24 as a p53 E3-ubiquitin ligase, establishing it as a direct enzymatic regulator of p53 stability conserved to Drosophila.

    Evidence TAP-tag/MS of endogenous p53 complexes, ubiquitylation assay, Drosophila bonus mosaic epistasis, human siRNA

    PMID:19556538

    Open questions at the time
    • Ubiquitin linkage type on p53 not specified
    • Regulation of the ligase activity not yet defined
  6. 2009 Medium

    Extended TRIM24 co-activation to androgen receptor, identifying TIP60 synergy and BRD7 antagonism in prostate cancer.

    Evidence Co-IP, luciferase reporter, transfection in prostate cancer cells

    PMID:19909775

    Open questions at the time
    • Single-lab reporter-based functional evidence
    • Direct AR target genes not mapped genome-wide
  7. 2010 High

    Resolved the structural logic of TRIM24 chromatin binding, showing the tandem PHD-bromodomain reads H3K4me0 and H3K23ac on one tail to activate ER-dependent proliferative genes.

    Evidence Crystal structure, histone peptide binding, ChIP, ER co-IP

    PMID:21164480

    Open questions at the time
    • Writer of H3K23ac not identified in this study
    • Genome-wide consequences of dual-mark reading not yet defined
  8. 2011 High

    Demonstrated TRIM24 acts within TIF1-subfamily complexes with TRIM33/TRIM28 and that these members cooperatively suppress hepatocarcinogenesis.

    Evidence Affinity purification/MS, hepatocyte-specific conditional knockouts, genetic epistasis

    PMID:21531907

    Open questions at the time
    • Stoichiometry and architecture of the complexes unresolved
    • Distinct vs shared target genes of the three members not separated
  9. 2011 High

    Showed TRIM24 represses the IFN/STAT pathway by binding the Stat1 promoter RARE with RARα, integrating its tumor-suppressor and immune-regulatory roles in liver.

    Evidence Trim24 knockout, ChIP of TRIM24/RARα at Stat1 promoter, Trim24-/- x Rara+/- epistasis

    PMID:21768647

    Open questions at the time
    • Whether repression is direct or co-regulator-dependent unresolved
    • Generalization beyond Stat1 to other IFN loci not tested
  10. 2014 High

    Defined the TRIM24-p53 feedback circuit, showing p53 induces TRIM24 transcription while ATM phosphorylation at S768 triggers TRIM24 auto-degradation to terminate the damage response.

    Evidence Phospho-specific antibodies, in vitro ubiquitination, p53 ChIP at TRIM24 promoter, S768 mutagenesis

    PMID:24820418

    Open questions at the time
    • Kinetics of loop relative to MDM2 not compared
    • How phosphorylation triggers auto-ubiquitination mechanistically unclear
  11. 2014 Medium

    Connected TRIM24 chromatin reading to oncogenic PI3K signaling, showing PHD-Bromo-dependent activation of PIK3CA transcription in glioma.

    Evidence ChIP, RT-PCR, promoter and domain mutation, PI3K inhibitor rescue

    PMID:24469053

    Open questions at the time
    • Single-lab finding
    • Upstream signal directing TRIM24 to PIK3CA not yet identified
  12. 2014 High

    Showed loss of TRIM24 disrupts hepatic metabolic homeostasis with steatosis, fibrosis and HCC, broadening its hepatic tumor-suppressor role to lipid metabolism.

    Evidence Global and liver-specific Trim24 knockouts, quantitative ChIP, genome-wide expression

    PMID:25281858

    Open questions at the time
    • Direct vs indirect repression of lipid genes not fully separated
    • Key metabolic target genes not pinpointed
  13. 2016 High

    Identified SPOP as the E3 adaptor degrading TRIM24, explaining how recurrent SPOP mutations stabilize TRIM24 to drive AR-dependent prostate cancer proliferation.

    Evidence Protein stability assays in SPOP-mutant vs WT cells, domain mutagenesis, ChIP-seq, proliferation assays

    PMID:27238081

    Open questions at the time
    • SPOP degron on TRIM24 not precisely mapped here
    • Contribution of E3 vs reader activity to proliferation not separated
  14. 2017 High

    Identified KAT6A as the H3K23 acetyltransferase that recruits TRIM24 to activate PIK3CA, completing the writer-reader axis driving PI3K/AKT in glioblastoma.

    Evidence Acetyltransferase assay, ChIP, TRIM24 H3K23ac-binding mutants, KAT6A catalytic mutant

    PMID:29021135

    Open questions at the time
    • Generality of KAT6A-TRIM24 axis beyond PIK3CA untested
    • Other H3K23ac readers not excluded
  15. 2017 High

    Showed EGFR-induced H3K23ac recruits TRIM24 to stabilize STAT3-chromatin interactions, extending its co-activator role to STAT3 signaling in glioma stem cells.

    Evidence Co-IP, ChIP, knockdown/overexpression in GSCs, EGFR inhibition

    PMID:29129908

    Open questions at the time
    • Direct STAT3-TRIM24 binding interface not mapped
    • Relationship to KAT6A-driven recruitment unresolved
  16. 2017 Medium

    Revealed a non-chromatin role: TRIM24 protects dysbindin from TRIM32 degradation to promote SRF signaling and cardiomyocyte hypertrophy.

    Evidence Yeast two-hybrid, co-IP, co-immunostaining, SRF reporter in neonatal rat cardiomyocytes

    PMID:28465353

    Open questions at the time
    • Single-lab, primarily in primary cardiomyocytes
    • Mechanism of protection from TRIM32 not detailed
  17. 2016 Medium

    Established a T-cell-intrinsic immune function, showing Trim24 is required for IL-1R expression on TH2 cells and IL-1β responsiveness in allergy.

    Evidence Mixed bone marrow chimera, flow cytometry, in vitro IL-1β stimulation, HDM allergy model

    PMID:26787865

    Open questions at the time
    • Molecular mechanism linking TRIM24 to IL-1R transcription unresolved
    • Single-lab
  18. 2018 High

    Showed chromatin binding licenses TRIM24 SUMOylation at K723/K741, coupling its reader function to a regulatory PTM affecting cell-adhesion gene programs.

    Evidence SUMO-site mutagenesis, IACS-9571 bromodomain inhibitor, HDAC inhibitor, expression profiling

    PMID:29523690

    Open questions at the time
    • SUMO E3 ligase responsible not identified
    • Functional output of SUMOylation incompletely defined
  19. 2018 High

    Identified TRIM28 as a stabilizer that shields TRIM24 from SPOP degradation and promotes its chromatin occupancy, explaining TRIM24 stability in SPOP-wildtype prostate cancer.

    Evidence Co-IP, ubiquitination assay, ChIP, siRNA, xenograft

    PMID:30479348

    Open questions at the time
    • Competition between TRIM28 protection and SPOP not quantified
    • Whether complex composition gates target selection unclear
  20. 2018 High

    Validated TRIM24 as a druggable degradation target, with a VHL-recruiting PROTAC revealing a TRIM24 dependency in acute leukemia beyond bromodomain inhibition.

    Evidence PROTAC dTRIM24 chemistry, ChIP-seq, proliferation assays in leukemia cells

    PMID:29507391

    Open questions at the time
    • Degradation-specific gene programs not fully separated from inhibition
    • On-target selectivity across cancer types not exhaustively profiled
  21. 2019 High

    Defined a ubiquitin-ligase mechanism in innate immunity: TRIM24 ubiquitinates CBP at K119 to drive Stat6 K383 acetylation, suppressing macrophage M2 polarization.

    Evidence Co-IP, ubiquitination and acetylation assays, site-specific mutagenesis, TRIM24 KO in mouse and human macrophages

    PMID:31554795

    Open questions at the time
    • Ubiquitin linkage on CBP not specified
    • How CBP ubiquitination promotes its recruitment mechanistically unclear
  22. 2020 High

    Revealed an antiviral cytoplasmic role: virus-induced TRIM24 mitochondrial translocation drives K63-linked TRAF3 ubiquitination at K429/K436 to assemble MAVS/TBK1 and amplify IFN-I signaling.

    Evidence Subcellular fractionation, K63-specific ubiquitination assay, TRAF3 mutagenesis, KO mice, VSV infection

    PMID:32324863

    Open questions at the time
    • Trigger for mitochondrial translocation not defined
    • Relationship to its nuclear functions unresolved
  23. 2020 Medium

    Identified TRIM24 as a negative regulator of RIP3, with its loss promoting necroptosis and accelerating osteoarthritis.

    Evidence Adenoviral shRNA in vivo, Rip3 KO mice, microarray, intra-articular injection model

    PMID:32895234

    Open questions at the time
    • Whether regulation of RIP3 is direct or transcriptional unclear
    • Single-lab
  24. 2020 Medium

    Connected TRIM24 to stemness, showing it activates Sox2 transcription to regulate GSC self-renewal and invasion.

    Evidence ChIP at Sox2 locus, reporter assay, knockdown/rescue, limiting dilution and xenotransplantation

    PMID:32492707

    Open questions at the time
    • Cofactors at Sox2 locus not identified
    • Single-lab
  25. 2021 High

    Demonstrated TRIM24 oncogenicity in vivo, with mammary overexpression driving carcinosarcoma via direct activation of Met and downstream PI3K/mTOR.

    Evidence Conditional Trim24 overexpression mouse, scRNA-seq, ChIP identifying Met, PI3K/mTOR inhibition, PROTAC in PDX

    PMID:34508101

    Open questions at the time
    • Chromatin marks directing TRIM24 to Met not defined
    • Tissue-specific oncogene vs tumor-suppressor switch unexplained
  26. 2021 Medium

    Extended ligase substrates to NLRP3, showing K48-linked ubiquitination that suppresses pyroptosis in endometrial stromal cells.

    Evidence Co-IP, ubiquitination assay, siRNA/overexpression, NLRP3 inhibitor rescue

    PMID:33724611

    Open questions at the time
    • Single-lab
    • Ubiquitination site on NLRP3 not mapped
  27. 2022 High

    Revealed an insulin-responsive cytoplasmic function: Akt phosphorylation drives TRIM24 nuclear export, where it ubiquitinates P-body components to stabilize Pparγ mRNA and promote hepatosteatosis.

    Evidence Phosphorylation-deficient and ligase-dead knockin mice, co-IP with P-body components, fractionation, mRNA stability assays

    PMID:35803934

    Open questions at the time
    • Specific P-body component substrates not fully enumerated
    • How polyubiquitylation stabilizes Pparγ mRNA mechanistically unclear
  28. 2023 High

    Refined the TRIM24-p53 relationship at genome scale, showing TRIM24 preferentially occupies p53 sites in closed chromatin and locally restricts p53-driven chromatin opening as a function of H3K4 methylation.

    Evidence Genome-wide TRIM24/p53 ChIP-seq, ATAC-seq, TRIM24 loss-of-function, viability assays

    PMID:37386214

    Open questions at the time
    • Interplay between this localization and TRIM24 ligase activity on p53 not integrated
    • Determinants of locus-specific outcomes incompletely defined
  29. 2023 High

    Identified a host-factor role in HIV-1, where TRIM24 constitutively associates with the LTR via TFII-I to promote transcriptional elongation through CDK9/P-TEFb recruitment and Pol II CTD S2 phosphorylation.

    Evidence Co-IP, LTR ChIP, knockdown, CTD phosphorylation and CDK9 recruitment assays, latency reactivation

    PMID:36690785

    Open questions at the time
    • Whether elongation role generalizes to cellular genes unknown
    • Recruitment of P-TEFb by TRIM24 mechanistically unresolved
  30. 2023 Medium

    Showed USP7 deubiquitinates and stabilizes TRIM24 to drive M1 macrophage polarization via STAT3-dependent SPLUNC1 expression, identifying a deubiquitinase counter to SPOP.

    Evidence Co-IP, deubiquitination assay, USP7 rescue, STAT3 ChIP at SPLUNC1, NPC xenograft

    PMID:38129408

    Open questions at the time
    • Single-lab
    • Reconciliation with TRIM24's M2-suppressing role via Stat6 not addressed
  31. 2023 Medium

    Placed TRIM24 in antiviral defense against EBV, where TRIM24/TRIM33 repress the BZLF1 lytic switch and EBV BZLF1 counter-attacks by disrupting TIF1 complexes and degrading TRIM24.

    Evidence SUMO proteomics, co-IP, TRIM24/TRIM33 knockdown, EBV reactivation reporter, MS

    PMID:37410772

    Open questions at the time
    • Single-lab
    • Mechanism of complex disruption by BZLF1 not fully defined
  32. 2024 Medium

    Showed TRIM24 mediates hepatoprotection by binding H3K27ac at the ORM2 promoter and recruiting RARα to upregulate ORM2 in OSAS/MASLD.

    Evidence ChIP-qPCR of H3K27ac/TRIM24 at ORM2, co-IP with RARα, overexpression and ORM2 rescue in mouse model

    PMID:39168366

    Open questions at the time
    • Single-lab
    • Reconciliation with RARα-repressive role in liver not addressed
  33. 2024 Medium

    Linked oncogenic Ras signaling to TRIM24 via a snoRNA-PHAX-DNA-PKcs axis, where DNA-PKcs phosphorylation at S767/768 drives epigenome reprogramming toward GBM-like transformation.

    Evidence Transformation assays in human NSCs, S767/768 mutagenesis, scRNA-seq, ChIP, NU7441 DNA-PKcs inhibitor, in vivo tumor model

    PMID:38828688

    Open questions at the time
    • Single-lab
    • Relationship of DNA-PKcs S767/768 phosphorylation to ATM S768 site not reconciled

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved how the same protein switches between liver tumor suppressor and oncogene in other tissues, and how its distinct nuclear reader, E3-ligase, and cytoplasmic RNA-regulatory activities are coordinated within a single cell.
  • Determinants of tissue-specific functional switch unknown
  • Coordination of nuclear vs cytoplasmic activities undefined
  • Unified model of complex composition controlling target selection lacking

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016874 ligase activity 5 GO:0140096 catalytic activity, acting on a protein 5 GO:0140110 transcription regulator activity 5 GO:0042393 histone binding 4 GO:0003677 DNA binding 3 GO:0140098 catalytic activity, acting on RNA 2
Localization
GO:0000228 nuclear chromosome 3 GO:0005634 nucleus 3 GO:0005739 mitochondrion 1 GO:0005829 cytosol 1
Pathway
R-HSA-162582 Signal Transduction 5 R-HSA-392499 Metabolism of proteins 5 R-HSA-1643685 Disease 4 R-HSA-168256 Immune System 4 R-HSA-74160 Gene expression (Transcription) 4 R-HSA-1430728 Metabolism 3 R-HSA-4839726 Chromatin organization 3 R-HSA-5357801 Programmed Cell Death 2
Partners
ARESR1RARASPOPSTAT3TP53TRIM28TRIM33
Complex memberships
TIF1 subfamily complex (TRIM24/TRIM28/TRIM33)

Evidence

Reading pass · 35 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1995 TIF1 (TRIM24) was identified as a nuclear protein that interacts with the ligand-binding domain of multiple nuclear receptors (RXR, RAR, ER, TR, VDR) in a ligand-dependent manner both in yeast two-hybrid and in vitro assays; these interactions require the AF-2 activating domain conserved in active nuclear receptors, and the ER AF-2 antagonist hydroxytamoxifen cannot promote ER-TIF1 interaction. Yeast two-hybrid; in vitro interaction assays; mammalian cell co-transfection The EMBO journal High 7744009
1996 TIF1 alpha (TRIM24) interacts physically with mouse HP1 alpha (mHP1α) and mMOD1 (HP1 homologs) via a conserved PXVXL motif identified in two-hybrid screening, implicating TIF1 alpha in chromatin-mediated transcriptional regulation. Yeast two-hybrid screening The EMBO journal Medium 8978696
1997 The human homolog hTIF1 (TRIM24) interacts in vitro with transcriptionally active estrogen receptor in a hormone-dependent manner; a region of 26 residues on hTIF1 is sufficient for this interaction, which requires the AF-2 activation domain of ER but not merely the conserved amphipathic alpha-helix. Interaction of hTIF1 with DNA-bound ER requires estradiol. Interaction is selective across nuclear receptor family members. In vitro pull-down; point mutagenesis of ER AF-2 domain; cDNA library screening The Journal of biological chemistry High 9115274
1999 In vitro, TIF1alpha (TRIM24) interacts with and phosphorylates HP1 proteins via a conserved PXVXL motif; however, endogenous TIF1alpha is NOT associated with HP1 by co-immunoprecipitation of nuclear extracts (unlike TIF1beta). The silencing activity of TIF1alpha results chiefly from histone deacetylation rather than HP1 binding. Co-immunoprecipitation of nuclear extracts; in vitro kinase assay; trichostatin A (HDAC inhibitor) treatment The EMBO journal High 10562550
2001 The Drosophila TIF1 homolog Bonus binds via an LxxLL motif to the AF-2 activation domain in the ligand-binding domain of betaFTZ-F1 nuclear receptor and acts as a transcriptional inhibitor in vivo; bon is required for male viability, molting, and metamorphosis. Yeast two-hybrid; in vivo genetic analysis; reporter assay Molecular cell Medium 11336699
2007 Loss of Trim24 (Tif1alpha) in mice causes failure of hepatocytes to exit the cell cycle during neonatal-to-adult transition, leading to metastatic hepatocellular carcinoma; genetic deletion of a single Rara allele in Trim24-null background suppresses HCC and restores wild-type retinoic acid-responsive gene expression, establishing that Trim24 and RARα co-regulate hepatocarcinogenesis antagonistically and that Trim24 functions as a liver-specific tumor suppressor by repressing RARα-mediated transcription. Knockout mouse model; genetic epistasis (Trim24-/- x Rara+/-); pharmacological RA signaling inhibition; gene expression analysis Nature genetics High 18026104
2009 TRIM24 was identified as a p53-interacting partner by mass spectrometry of TAP-purified endogenous p53 complexes from mouse embryonic stem cells; TRIM24 ubiquitylates p53 as an E3-ubiquitin ligase and promotes its proteasome-mediated degradation. In Drosophila, mosaic deletion of the TRIM24 homolog bonus causes apoptosis rescued by p53 depletion, establishing the pathway conservation in vivo. TAP-tag knock-in; mass spectrometry; ubiquitylation assay; Drosophila mosaic genetics; siRNA knockdown in human cells Proceedings of the National Academy of Sciences of the United States of America High 19556538
2010 TRIM24 functions as a dual histone mark reader via tandem PHD-bromodomain: the crystal structure of the PHD-Bromo region of TRIM24 reveals a single functional unit that simultaneously recognizes unmodified H3K4 (H3K4me0) and acetylated H3K23 (H3K23ac) within the same histone tail. TRIM24 binds chromatin and estrogen receptor to activate estrogen-dependent genes associated with cellular proliferation. Crystal structure (X-ray crystallography); histone peptide binding assays; chromatin immunoprecipitation; co-immunoprecipitation with ER Nature High 21164480
2009 TRIM24 mediates ligand-dependent activation of androgen receptor (AR); TRIM24 interacts with AR and enhances AR transcriptional activity in prostate cancer cells stimulated with dihydrotestosterone. TRIM24 synergizes with TIP60 coactivator for AR transactivation. BRD7 binds TRIM24 and represses the AR transactivation activity upregulated by TRIM24. Co-immunoprecipitation; luciferase reporter assay; transfection in prostate cancer cells Biochimica et biophysica acta Medium 19909775
2011 TRIM24 can be purified as macromolecular complexes comprising either TRIM33 or TRIM33 and TRIM28; somatic hepatocyte-specific inactivation of TRIM24, TRIM28, or TRIM33 each promotes HCC in mice in a cell-autonomous manner, and HCC formation upon TRIM24 inactivation is potentiated by further loss of TRIM33, demonstrating physical and functional interaction within the TIF1 subfamily. Affinity purification/mass spectrometry; hepatocyte-specific conditional knockout mouse models; genetic epistasis Proceedings of the National Academy of Sciences of the United States of America High 21531907
2011 Loss of Trim24 results in IFN/STAT pathway overactivation in mouse liver; Trim24 together with RARα binds the retinoic acid-responsive element (RARE) of the Stat1 promoter and represses its RA-induced transcription; RARα haplodeficiency in Trim24-null mice prevents IFN/STAT overactivation, establishing Trim24 as a novel negative regulator of the IFN/STAT pathway acting through RARα inhibition. Trim24 knockout mouse model; chromatin immunoprecipitation (ChIP) of Trim24 and RARα at Stat1 promoter; genetic epistasis (Trim24-/- x Rara+/-); gene expression profiling The Journal of biological chemistry High 21768647
2014 TRIM24 is a p53-induced E3-ubiquitin ligase that undergoes ATM-mediated phosphorylation at S768 in response to DNA damage, which disrupts TRIM24-p53 interactions and promotes TRIM24 auto-degradation. p53 directly induces TRIM24 transcription by binding p53 response elements. Newly synthesized TRIM24 then ubiquitinates and degrades activated p53, creating an autoregulatory feedback loop analogous to MDM2 but specifically targeting activated p53 to terminate the DNA damage response. Phospho-specific antibodies; in vitro ubiquitination assay; chromatin immunoprecipitation of p53 at TRIM24 promoter; siRNA knockdown; site-directed mutagenesis (S768) Molecular and cellular biology High 24820418
2014 TRIM24 binds to the PIK3CA promoter via its PHD-Bromo domain to activate PIK3CA transcription, thereby enhancing PI3K/Akt signaling in glioma cells; PHD-Bromo domain mutation abrogates this activity. Chromatin immunoprecipitation (ChIP); real-time RT-PCR; promoter mutation analysis; PI3K inhibitor treatment Oncogene Medium 24469053
2014 TRIM24 globally loss of function in mice disrupts hepatic homeostasis, decreasing expression of oxidation/reduction, fatty acid and lipid metabolism genes and increasing ER stress/cell cycle pathway genes, with spontaneous development of hepatic steatosis, fibrosis and HCC; TRIM24 directly and indirectly represses hepatic lipid accumulation. Global and liver-specific Trim24 knockout mouse models; quantitative ChIP; global RNA expression analysis Journal of hepatology High 25281858
2016 TRIM24 protein is stabilized by recurrent PC-driver mutations in SPOP (an E3 ubiquitin ligase adaptor that normally targets TRIM24 for degradation), promoting cell proliferation under low androgen conditions. TRIM24 augments AR signaling in prostate cancer; the TRIM24 bromodomain and AR-interacting motif are both essential for supporting proliferation in CRPC cells. Protein stability assays in SPOP-mutant vs. wildtype prostate cancer cells; domain deletion/mutation; ChIP-seq; gene expression analysis; proliferation assays Cancer cell High 27238081
2017 KAT6A acetyltransferase acetylates H3K23, which recruits TRIM24 to activate PIK3CA transcription and enhance PI3K/AKT signaling in glioblastoma; TRIM24 mutants lacking H3K23ac-binding sites fail to promote PIK3CA expression or AKT phosphorylation. Histone acetyltransferase assay; ChIP; western blot; TRIM24 H3K23ac-binding domain mutation; KAT6A catalytic mutant Cancer research High 29021135
2017 TRIM24 functions as a transcriptional co-activator that recruits STAT3 upon H3K23ac-mediated chromatin binding downstream of EGFR signaling in glioblastoma; EGFR signaling promotes H3K23 acetylation, association with TRIM24, and subsequent stabilization of STAT3-chromatin interactions to activate STAT3 downstream signaling. Co-immunoprecipitation; ChIP; TRIM24 knockdown/overexpression in glioma cell lines and patient-derived GSCs; EGFR pathway inhibition Nature communications High 29129908
2018 TRIM28 interacts with TRIM24 protein to prevent its ubiquitination and degradation by SPOP; TRIM28 facilitates TRIM24 occupancy on chromatin and augments AR signaling in prostate cancer, providing a mechanism for TRIM24 stabilization in SPOP-wildtype prostate cancers. Co-immunoprecipitation; ubiquitination assay; ChIP; siRNA knockdown; xenograft tumor growth assay Nature communications High 30479348
2018 Binding of TRIM24 to chromatin via its tandem PHD-bromodomain (recognizing H3K4me0/K23ac) leads to TRIM24 SUMOylation at K723 and K741; bromodomain inactivation (by mutation or IACS-9571 inhibitor) abolishes TRIM24 SUMOylation. HDAC inhibition increases TRIM24 chromatin interaction and SUMOylation. SUMO-deficient TRIM24 alters cell adhesion gene expression in MCF7 cells. Site-directed mutagenesis of SUMO acceptor sites; IACS-9571 bromodomain inhibitor; HDAC inhibitor treatment; gene expression profiling The Journal of biological chemistry High 29523690
2018 TRIM24 functions as a functional protein degrader target: heterobifunctional PROTAC dTRIM24 recruits VHL E3 ubiquitin ligase to elicit potent and selective TRIM24 protein degradation, which reveals TRIM24 as a novel dependency in acute leukemia and shows enhanced anti-proliferative response from degradation versus bromodomain inhibition alone. PROTAC/degrader chemistry; western blot quantification of TRIM24 levels; genome-wide ChIP-seq; proliferation assays in leukemia cells Nature chemical biology High 29507391
2019 TRIM24 promotes Stat6 acetylation at K383 by catalyzing CBP ubiquitination at K119, which facilitates CBP recruitment to Stat6; this Stat6 acetylation suppresses macrophage M2 polarization. Loss of TRIM24 inhibits Stat6 acetylation and promotes M2 polarization in mouse and human macrophages. Co-immunoprecipitation; ubiquitination assay; acetylation assay; TRIM24 knockout/knockdown in macrophages; site-specific mutation of CBP K119 and Stat6 K383 Nature communications High 31554795
2020 Upon RNA virus (VSV) infection, TRIM24 translocates to mitochondria and directly mediates K63-linked ubiquitination of TRAF3 at K429/K436; this modification enables TRAF3 association with MAVS and TBK1 to activate downstream antiviral IFN-I signaling. TRIM24 deficiency compromises IFN-I induction and renders mice more sensitive to VSV infection. Subcellular fractionation/localization (TRIM24 mitochondrial translocation); in vitro ubiquitination assay (K63-specific); co-immunoprecipitation of TRAF3 with MAVS/TBK1; site-directed mutagenesis of TRAF3 K429/K436; TRIM24 knockout mice The Journal of experimental medicine High 32324863
2020 TRIM24 knockdown upregulates RIP3 expression, and TRIM24 acts as a negative regulator of RIP3 in chondrocytes; loss of TRIM24 promotes RIP3-mediated necroptosis and accelerates osteoarthritis pathogenesis in a mouse model. Adenoviral TRIM24 shRNA in vivo; Rip3 knockout mice; microarray/in silico analysis identifying TRIM24 as RIP3 regulator; intra-articular injection model Annals of the rheumatic diseases Medium 32895234
2021 Conditional overexpression of TRIM24 in mouse mammary epithelia drives spontaneous development of metaplastic carcinosarcoma tumors; single-cell and global profiling reveals Met as a direct oncogenic target of TRIM24, with subsequent aberrant PI3K/mTOR activation. Conditional mouse mammary overexpression model (Trim24COE); single-cell RNA sequencing; ChIP to identify Met as TRIM24 target; pharmacological PI3K/mTOR inhibition; TRIM24-PROTAC treatment of PDX tumorspheres Nature communications High 34508101
2021 TRIM24 interacts with NLRP3 and facilitates K48-linked ubiquitination of NLRP3, thereby negatively regulating NLRP3/caspase-1/IL-1β-mediated pyroptosis and cell migration in endometrial stromal cells. Co-immunoprecipitation; ubiquitination assay; TRIM24 siRNA and overexpression; NLRP3 inhibitor rescue experiment Cell biology international Medium 33724611
2022 Upon insulin stimulation, PKB/Akt phosphorylates TRIM24, stimulating its shuttling from nucleus to cytoplasm; cytoplasmic TRIM24 interacts with P-body components, promoting their polyubiquitylation, which stabilizes Pparγ mRNA. Knockin mutations preventing TRIM24 phosphorylation or inactivating its E3-ligase activity promote hepatic Pparγ degradation via P-bodies and alleviate hepatosteatosis in mice fed a high-fat diet. In vivo knockin mouse models (phosphorylation-deficient and E3-ligase-dead TRIM24); co-immunoprecipitation with P-body components; subcellular fractionation; mRNA stability assay; insulin stimulation Nature communications High 35803934
2023 TRIM24 binds both p53 and unmethylated H3K4 (H3K4me0), preferentially localizing to p53 binding sites in closed chromatin while being deterred from accessible chromatin by H3K4 methylation; TRIM24 locally restricts p53's ability to open chromatin and activate target genes, increases cell viability upon stress, and enables p53 to affect gene expression as a function of the local chromatin state. Genome-wide ChIP-seq (TRIM24 and p53 co-occupancy); ATAC-seq (chromatin accessibility); TRIM24 loss-of-function; histone modification profiling; cell viability assays Nature structural & molecular biology High 37386214
2023 TRIM24 constitutively associates with the HIV-1 LTR through interaction with TFII-I (RBF-2); TRIM24 deficiency impairs HIV-1 reactivation from latency by inhibiting transcriptional elongation, associated with decreased RNA Pol II CTD S2 phosphorylation and impaired CDK9 (P-TEFb) recruitment, without affecting RNA Pol II recruitment to the promoter. Co-immunoprecipitation (TRIM24-TFII-I interaction); ChIP (LTR occupancy); TRIM24 knockdown; RNA Pol II CTD phosphorylation analysis; CDK9 recruitment assay; HIV-1 latency reactivation assay Communications biology High 36690785
2023 USP7 deubiquitinates and stabilizes TRIM24; stabilized TRIM24 promotes SPLUNC1 expression via STAT3 recruitment in macrophages, driving M1 macrophage polarization. Co-immunoprecipitation; deubiquitination assay; TRIM24 knockdown/overexpression; USP7 overexpression rescue; ChIP of STAT3 at SPLUNC1 promoter; in vivo NPC xenograft Cell death & disease Medium 38129408
2023 TRIM24 and TRIM33 repress expression of the EBV BZLF1 lytic switch gene, suppressing EBV reactivation; BZLF1 interacts with TRIM24 and TRIM33, disrupting TRIM24/TRIM28/TRIM33 complexes and causing TRIM24 degradation, thus disabling this antiviral defense. During EBV lytic infection, TRIM24 is rapidly degraded and undergoes changes in SUMO modification status. SUMO proteomics (site-specific); co-immunoprecipitation; TRIM24/TRIM33 knockdown; EBV reactivation reporter assay; mass spectrometry PLoS pathogens Medium 37410772
2024 HRasV12 activates PHAX and upregulates U3 snoRNAs, which recruit TRIM24; overexpressed TRIM24 is recruited by PHAX to U3 snoRNAs, facilitating DNA-PKcs phosphorylation of TRIM24 at S767/768. Phosphorylated TRIM24 drives epigenome and transcription factor network reprogramming promoting epithelioid GBM-like transformation; targeting DNA-PKcs with NU7441 reduces tumorigenicity. Co-transfection/transformation assays in human NSCs; site-directed mutagenesis (S767/768); scRNA-seq; ChIP; small-molecule DNA-PKcs inhibitor (NU7441); in vivo tumor model Advanced science Medium 38828688
2017 TRIM24 promotes cardiomyocyte hypertrophy by protecting dysbindin from TRIM32-mediated ubiquitination/degradation; TRIM24 interacts with dysbindin (confirmed by co-immunoprecipitation and co-immunostaining) and promotes dysbindin-mediated SRF signaling and hypertrophy in neonatal rat ventricular cardiomyocytes. Yeast two-hybrid (cardiac cDNA library); co-immunoprecipitation; co-immunostaining; SRF reporter assay; overexpression/knockdown in neonatal rat ventricular cardiomyocytes The Journal of biological chemistry Medium 28465353
2016 T-cell-intrinsic Trim24 is required for IL-1R expression on TH2 cells; Trim24-deficient T cells have reduced IL-1 receptor expression, are refractory to IL-1β-mediated activation, and fail to respond to IL-1β-exacerbated airway allergy, establishing a Trim24-dependent mechanism for IL-1R expression in TH2-mediated immunity. Mixed bone marrow chimera (T-cell-specific Trim24 deficiency); flow cytometry (IL-1R surface expression); in vitro IL-1β stimulation; HDM allergy model in vivo Proceedings of the National Academy of Sciences of the United States of America Medium 26787865
2020 TRIM24 activates the expression of Sox2 (pluripotency transcription factor) in glioblastoma to regulate GSC stemness and invasion; this was demonstrated by chromatin immunoprecipitation showing TRIM24 occupancy at the Sox2 locus and reporter gene assays showing TRIM24-driven Sox2 transcription. Chromatin immunoprecipitation (ChIP); reporter gene assay; TRIM24 knockdown/rescue; limiting dilution and xenotransplantation assays Neuro-oncology Medium 32492707
2024 TRIM24 upregulates expression of ORM2 (a key regulator of hepatic lipogenesis) by binding to H3K27ac at the ORM2 promoter and recruiting retinoic acid receptor-α; this mechanism mediates hepatoprotective effects of TRIM24 in a model of OSAS and MASLD. ChIP-qPCR (H3K27ac and TRIM24 at ORM2 promoter); co-immunoprecipitation (TRIM24 with RARα); TRIM24 overexpression; ORM2 rescue experiment in OSAS/MASLD mouse model The American journal of pathology Medium 39168366

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1995 The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18. The EMBO journal 576 7744009
1996 A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors. The EMBO journal 473 8978696
2010 TRIM24 links a non-canonical histone signature to breast cancer. Nature 360 21164480
1999 Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family. The EMBO journal 317 10562550
2019 Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24. Nature communications 299 31554795
1996 Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1. The EMBO journal 260 8598193
1996 Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1. Nucleic acids research 260 9016654
2009 Trim24 targets endogenous p53 for degradation. Proceedings of the National Academy of Sciences of the United States of America 246 19556538
2016 TRIM24 Is an Oncogenic Transcriptional Activator in Prostate Cancer. Cancer cell 229 27238081
1974 Thermal enhancement of ultraviolet mutability in a tif-1 uvrA derivative of Escherichia coli B-r: evidence that ultraviolet mutagenesis depends upon an inducible function. Proceedings of the National Academy of Sciences of the United States of America 225 4600265
2010 Anti-MDA5 and anti-TIF1-gamma antibodies have clinical significance for patients with dermatomyositis. Rheumatology (Oxford, England) 216 20501546
2011 Transcription cofactors TRIM24, TRIM28, and TRIM33 associate to form regulatory complexes that suppress murine hepatocellular carcinoma. Proceedings of the National Academy of Sciences of the United States of America 184 21531907
2018 Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands. Nature chemical biology 181 29507391
1999 The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas. Oncogene 138 10439047
2007 Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha. Nature genetics 137 18026104
2015 Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor. Journal of medicinal chemistry 127 26061247
1989 An essential yeast protein, encoded by duplicated genes TIF1 and TIF2 and homologous to the mammalian translation initiation factor eIF-4A, can suppress a mitochondrial missense mutation. Proceedings of the National Academy of Sciences of the United States of America 126 2648398
2014 TRIM24 promotes glioma progression and enhances chemoresistance through activation of the PI3K/Akt signaling pathway. Oncogene 117 24469053
2017 TRIM24 is an oncogenic transcriptional co-activator of STAT3 in glioblastoma. Nature communications 116 29129908
2017 Histone Acetyltransferase KAT6A Upregulates PI3K/AKT Signaling through TRIM24 Binding. Cancer research 106 29021135
2018 TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression. Nature communications 100 30479348
2015 Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF. Journal of medicinal chemistry 95 25974391
2014 TRIM24 is a p53-induced E3-ubiquitin ligase that undergoes ATM-mediated phosphorylation and autodegradation during DNA damage. Molecular and cellular biology 90 24820418
2005 8p11 myeloproliferative syndrome with a novel t(7;8) translocation leading to fusion of the FGFR1 and TIF1 genes. Genes, chromosomes & cancer 89 15609342
2009 TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells. Biochimica et biophysica acta 86 19909775
2018 Tumour TIF1 mutations and loss of heterozygosity related to cancer-associated myositis. Rheumatology (Oxford, England) 84 29149307
2001 Bonus, a Drosophila homolog of TIF1 proteins, interacts with nuclear receptors and can inhibit betaFTZ-F1-dependent transcription. Molecular cell 82 11336699
1997 Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1. The Journal of biological chemistry 82 9115274
1975 Persistence and decay of thermoinducible error-prone repair activity in nonfilamentous derivatives of tif-1, Escherichia coli B/r: the timing of some critical events in ultraviolet mutagenesis. Molecular & general genetics : MGG 79 765739
2012 Overexpression of TRIM24 correlates with tumor progression in non-small cell lung cancer. PloS one 75 22666376
2020 TRIM24-RIP3 axis perturbation accelerates osteoarthritis pathogenesis. Annals of the rheumatic diseases 73 32895234
2004 TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids. The Journal of biological chemistry 68 15322135
2014 TRIM24 suppresses development of spontaneous hepatic lipid accumulation and hepatocellular carcinoma in mice. Journal of hepatology 67 25281858
2020 TIF1 Proteins in Genome Stability and Cancer. Cancers 66 32731534
2011 Tripartite motif 24 (Trim24/Tif1α) tumor suppressor protein is a novel negative regulator of interferon (IFN)/signal transducers and activators of transcription (STAT) signaling pathway acting through retinoic acid receptor α (Rarα) inhibition. The Journal of biological chemistry 62 21768647
2009 Regulation of p53: TRIM24 enters the RING. Cell cycle (Georgetown, Tex.) 59 19844164
2021 E3 ubiquitin ligase TRIM24 deficiency promotes NLRP3/caspase-1/IL-1β-mediated pyroptosis in endometriosis. Cell biology international 58 33724611
2013 TRIM24 overexpression is common in locally advanced head and neck squamous cell carcinoma and correlates with aggressive malignant phenotypes. PloS one 58 23717505
2017 Regulation of TRIM24 by miR-511 modulates cell proliferation in gastric cancer. Journal of experimental & clinical cancer research : CR 57 28114950
2014 Overexpression of TRIM24 is associated with the onset and progress of human hepatocellular carcinoma. PloS one 57 24409330
2020 Anti-TIF1-γ autoantibodies: warning lights of a tumour autoantigen. Rheumatology (Oxford, England) 56 31883334
2020 TRIM24 facilitates antiviral immunity through mediating K63-linked TRAF3 ubiquitination. The Journal of experimental medicine 51 32324863
2015 TRIM24 is upregulated in human gastric cancer and promotes gastric cancer cell growth and chemoresistance. Virchows Archiv : an international journal of pathology 49 25724180
2014 TRIM24 links glucose metabolism with transformation of human mammary epithelial cells. Oncogene 49 25065590
2017 Glucose transporter 4 promotes head and neck squamous cell carcinoma metastasis through the TRIM24-DDX58 axis. Journal of hematology & oncology 47 28061796
1983 DNA repair properties of Escherichia coli tif-1, recAo281 and lexA1 strains deficient in single-strand DNA binding protein. Molecular & general genetics : MGG 47 6222244
1981 tif-1 mutation alters polynucleotide recognition by the recA protein of Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America 47 7031642
1999 Expression of nuclear receptor interacting proteins TIF-1, SUG-1, receptor interacting protein 140, and corepressor SMRT in tamoxifen-resistant breast cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 45 10589759
2020 Long non-coding RNA NCK1-AS1 promotes the tumorigenesis of glioma through sponging microRNA-138-2-3p and activating the TRIM24/Wnt/β-catenin axis. Journal of experimental & clinical cancer research : CR 44 32293515
2019 Therapeutic effects of human monoclonal PSMA antibody-mediated TRIM24 siRNA delivery in PSMA-positive castration-resistant prostate cancer. Theranostics 43 30867828
2017 TRIM24 promotes the aggression of gastric cancer via the Wnt/β-catenin signaling pathway. Oncology letters 42 28454326
2020 TRIM24 promotes stemness and invasiveness of glioblastoma cells via activating Sox2 expression. Neuro-oncology 41 32492707
2017 TRIM24 protein promotes and TRIM32 protein inhibits cardiomyocyte hypertrophy via regulation of dysbindin protein levels. The Journal of biological chemistry 39 28465353
2012 TiF1-gamma plays an essential role in murine hematopoiesis and regulates transcriptional elongation of erythroid genes. Developmental biology 35 23159334
2023 Readout of histone methylation by Trim24 locally restricts chromatin opening by p53. Nature structural & molecular biology 34 37386214
2021 Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer. Nature communications 34 34508101
2023 USP7 inhibits the progression of nasopharyngeal carcinoma via promoting SPLUNC1-mediated M1 macrophage polarization through TRIM24. Cell death & disease 33 38129408
2018 Cross-talk between chromatin acetylation and SUMOylation of tripartite motif-containing protein 24 (TRIM24) impacts cell adhesion. The Journal of biological chemistry 32 29523690
2007 Dynamic and selective interactions of the transcriptional corepressor TIF1 beta with the heterochromatin protein HP1 isotypes during cell differentiation. Differentiation; research in biological diversity 31 17381543
2020 BMP8A promotes survival and drug resistance via Nrf2/TRIM24 signaling pathway in clear cell renal cell carcinoma. Cancer science 30 32128917
2019 NCK1-AS1 Increases Drug Resistance of Glioma Cells to Temozolomide by Modulating miR-137/TRIM24. Cancer biotherapy & radiopharmaceuticals 29 31750728
2008 Trim24 (Tif1 alpha): an essential 'brake' for retinoic acid-induced transcription to prevent liver cancer. Cell cycle (Georgetown, Tex.) 29 19029830
1985 Evidence that the recA441 (tif-1) mutant of Escherichia coli K-12 contains a thermosensitive intragenic suppressor of RecA constitutive protease activity. Journal of bacteriology 28 3891740
2016 T-cell-intrinsic Tif1α/Trim24 regulates IL-1R expression on TH2 cells and TH2 cell-mediated airway allergy. Proceedings of the National Academy of Sciences of the United States of America 25 26787865
2015 Clinical significance and biological roles of TRIM24 in human bladder carcinoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 25 25846736
2022 STAT1 is regulated by TRIM24 and promotes immunosuppression in head and neck squamous carcinoma cells, but enhances T cell antitumour immunity in the tumour microenvironment. British journal of cancer 24 35595823
2019 Epigenetic silencing of miR-137 induces resistance to bicalutamide by targeting TRIM24 in prostate cancer cells. American journal of translational research 24 31217891
2017 Overexpression of TRIM24 is correlated with the progression of human cervical cancer. American journal of translational research 24 28337289
2022 TRIM24 is an insulin-responsive regulator of P-bodies. Nature communications 23 35803934
1980 Suppression of induction of SOS functions in an Escherichia coli tif-1 mutant by plasmid R100.1. Journal of bacteriology 22 6444942
2021 Linc00963 Promote Cell Proliferation and Tumor Growth in Castration-Resistant Prostate Cancer by Modulating miR-655/TRIM24 Axis. Frontiers in oncology 21 33643926
1991 Specificity of recA441-mediated (tif-1) mutational events. Molecular & general genetics : MGG 21 1745244
2004 Bonus, a Drosophila TIF1 homolog, is a chromatin-associated protein that acts as a modifier of position-effect variegation. Genetics 20 15545640
2022 TRIM24 promotes colorectal cancer cell progression via the Wnt/β-catenin signaling pathway activation. American journal of translational research 19 35273688
2020 Transcriptional intermediary factor 1 (TIF1) and anti-TIF1γ antibody-positive dermatomyositis. Immunological medicine 19 32649853
2020 Long non‑coding RNA ZFPM2‑AS1 promotes colorectal cancer progression by sponging miR‑137 to regulate TRIM24. Molecular medicine reports 19 33300060
2016 Clinical characteristics of patients with anti-TIF1-γ antibodies. Reumatologia 19 27407271
1979 Thermoresistant revertants of an Escherichia coli strain carrying tif-1 and ruv mutations: non-suppressibility of ruv by sfi. Journal of bacteriology 19 374356
2023 TRIM24 controls induction of latent HIV-1 by stimulating transcriptional elongation. Communications biology 17 36690785
2022 ELISA, protein immunoprecipitation and line blot assays for anti-TIF1-gamma autoantibody detection in cancer-associated dermatomyositis. Rheumatology (Oxford, England) 17 35579337
2018 TRIM24 promotes hepatocellular carcinoma progression via AMPK signaling. Experimental cell research 17 29627320
2006 TIF1 activates the intra-S-phase checkpoint response in the diploid micronucleus and amitotic polyploid macronucleus of Tetrahymena. Molecular biology of the cell 17 17005912
2005 TIF1 Represses rDNA replication initiation, but promotes normal S phase progression and chromosome transmission in Tetrahymena. Molecular biology of the cell 17 15772155
2020 Downregulation of circEPSTI1 represses the proliferation and invasion of non-small cell lung cancer by inhibiting TRIM24 via miR-1248 upregulation. Biochemical and biophysical research communications 16 32828310
2001 Cloning and biochemical analysis of the tetrahymena origin binding protein TIF1: competitive DNA binding in vitro and in vivo to critical rDNA replication determinants. The Journal of biological chemistry 16 11577092
2021 LncRNA PVT1 promotes tumorigenesis of glioblastoma by recruiting COPS5 to deubiquitinate and stabilize TRIM24. Molecular therapy. Nucleic acids 15 34938610
2018 Overexpression of TRIM24 Stimulates Proliferation and Glucose Metabolism of Head and Neck Squamous Cell Carcinoma. BioMed research international 15 29862279
2023 Natural variation in Tiller Number 1 affects its interaction with TIF1 to regulate tillering in rice. Plant biotechnology journal 14 36705337
2019 Discovery and optimization of novel N-benzyl-3,6-dimethylbenzo[d]isoxazol-5-amine derivatives as potent and selective TRIM24 bromodomain inhibitors with potential anti-cancer activities. Bioorganic chemistry 14 31776034
2018 TRIM24 siRNA induced cell apoptosis and reduced cell viability in human nasopharyngeal carcinoma cells. Molecular medicine reports 14 29749443
2017 The polar warhead of a TRIM24 bromodomain inhibitor rearranges a water-mediated interaction network. The FEBS journal 14 28207202
2023 Changes in SUMO-modified proteins in Epstein-Barr virus infection identifies reciprocal regulation of TRIM24/28/33 complexes and the lytic switch BZLF1. PLoS pathogens 13 37410772
2022 Discovery, optimization and evaluation of 1-(indolin-1-yl)ethan-1-ones as novel selective TRIM24/BRPF1 bromodomain inhibitors. European journal of medicinal chemistry 13 35385803
2022 Paraneoplastic Anti-Tif1-gamma Autoantibody-positive Dermatomyositis as Clinical Presentation of Hepatocellular Carcinoma Recurrence. Journal of clinical and translational hepatology 12 36406323
2021 The Association between TIF1 Family Members and Cancer Stemness in Solid Tumors. Cancers 12 33810347
2020 Trim24 prompts tumor progression via inducing EMT in renal cell carcinoma. Open medicine (Warsaw, Poland) 12 33336072
2019 TRIM24 aggravates the progression of ovarian cancer through negatively regulating FOXM1 level. European review for medical and pharmacological sciences 12 31858531
2016 Development of a methodology for in vivo follow-up of hepatocellular carcinoma in hepatocyte specific Trim24-null mice treated with myo-inositol trispyrophosphate. Journal of experimental & clinical cancer research : CR 12 27686696
2024 TRIM24 Up-Regulates ORM2 to Alleviate Abnormal Lipid Metabolism, Inflammation, and Oxidative Stress in Mice with Obstructive Sleep Apnea Syndrome and Metabolic Dysfunction-Associated Steatotic Liver Disease. The American journal of pathology 11 39168366
2024 TRIM24 Cooperates with Ras Mutation to Drive Glioma Progression through snoRNA Recruitment of PHAX and DNA-PKcs. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 10 38828688

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