Affinage

TRAIP

E3 ubiquitin-protein ligase TRAIP · UniProt Q9BWF2

Length
469 aa
Mass
53.3 kDa
Annotated
2026-04-28
100 papers in source corpus 20 papers cited in narrative 20 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

TRAIP is a RING-domain E3 ubiquitin ligase that functions as a central regulator of DNA replication integrity, replisome dynamics, and replication-coupled DNA repair. During S-phase, TRAIP binds PCNA via a conserved PIP box and operates at replication forks to promote ATR checkpoint signaling, facilitate translesion synthesis through ubiquitylation of DNA polymerase η, resolve replication-transcription conflicts at transcription start sites, and control interstrand crosslink repair pathway choice by ubiquitylating the CMG helicase—where short ubiquitin chains recruit NEIL3 and longer chains trigger p97-dependent CMG unloading enabling Fanconi anemia repair (PMID:26711499, PMID:30842657, PMID:24553286, PMID:37604812). During mitosis, TRAIP drives disassembly of residual replisomes by generating K6/K63-linked ubiquitin chains on MCM7, enabling p97-mediated extraction to prevent chromosome mis-segregation, and regulates spindle assembly checkpoint function through MAD2 kinetochore levels (PMID:30979826, PMID:31545170, PMID:25335891). Biallelic TRAIP mutations cause microcephalic primordial dwarfism, consistent with its essential roles in replication fork progression through DNA lesions and embryonic cell proliferation (PMID:26595769, PMID:17927961).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 1997 High

    Establishing TRAIP as a TRAF-interacting RING-finger protein that inhibits NF-κB signaling resolved how TNFR2/CD30 pathways are negatively regulated at the level of TRAF2.

    Evidence Yeast two-hybrid, co-immunoprecipitation, and NF-κB reporter assays in mammalian cells

    PMID:9104814

    Open questions at the time
    • Ubiquitin ligase activity not yet tested
    • In vivo relevance of NF-κB inhibition unknown
    • Substrates of the RING domain unidentified
  2. 2003 High

    Identification of the TRAIP–CYLD interaction revealed a cooperative axis for NF-κB suppression and placed TRAIP within the deubiquitinase regulatory network.

    Evidence Yeast two-hybrid, far-Western, co-immunoprecipitation, NF-κB reporter assays

    PMID:14676304

    Open questions at the time
    • Whether CYLD deubiquitinates TRAIP substrates not tested
    • Physiological tissue contexts not explored
  3. 2007 High

    Demonstration that TRAIP is a bona fide RING-dependent E3 ubiquitin ligase with auto-ubiquitination activity established its enzymatic identity, while knockout mice revealed essential roles in embryonic proliferation.

    Evidence In vitro ubiquitination assay with RING mutants; homozygous knockout mouse embryo phenotyping

    PMID:17544371 PMID:17927961

    Open questions at the time
    • Physiological substrates remain unidentified
    • Mechanism of embryonic lethality (proliferation versus apoptosis) not dissected at molecular level
  4. 2012 High

    Showing that TRAIP promotes K48-linked polyubiquitination and proteasomal degradation of TBK1 established TRAIP as a negative regulator of innate antiviral IFN-β signaling, broadening its functional scope beyond NF-κB.

    Evidence Co-immunoprecipitation, ubiquitination assays, siRNA knockdown, viral replication assays in mammalian cells

    PMID:22945920

    Open questions at the time
    • Whether TBK1 is a direct TRAIP substrate reconstituted in vitro not shown
    • In vivo antiviral phenotype not tested in animal model
  5. 2014 High

    Discovery that TRAIP ubiquitylates DNA polymerase η to promote translesion synthesis, and that TRAIP localizes near mitotic chromosomes where it regulates spindle assembly checkpoint through MAD2 kinetochore levels, pivoted the field toward replication and mitotic functions.

    Evidence Ubiquitination assays and Drosophila genetic epistasis for Polη; RNAi in HeLa with live imaging and ligase-dead rescue for mitotic phenotypes

    PMID:24553286 PMID:25335891

    Open questions at the time
    • Identity of mitotic substrates at kinetochores unknown
    • How Polη ubiquitylation activates translesion synthesis mechanistically unclear
  6. 2015 High

    Mapping TRAIP's PCNA interaction via a PIP box and linking it to ATR checkpoint signaling and replication fork integrity established TRAIP as a replisome-associated E3 ligase, while patient mutations causing microcephalic primordial dwarfism validated its essentiality for replication through DNA lesions in humans.

    Evidence PIP box mutagenesis, ATR/RPA2 phosphorylation assays, DNA fiber assays, human genetics with patient-derived cells

    PMID:26595769 PMID:26711499

    Open questions at the time
    • Direct TRAIP substrate at stalled forks generating ssDNA not identified
    • Whether disease mutations selectively affect replication versus mitotic functions unknown
  7. 2016 High

    Placing TRAIP upstream of RAP80 and BRCA1 recruitment at DNA damage sites through interaction with RNF20-RNF40 connected TRAIP to homologous recombination repair.

    Evidence Reciprocal co-immunoprecipitation, domain mapping, siRNA epistasis, immunofluorescence at DNA damage foci

    PMID:26781088

    Open questions at the time
    • Whether TRAIP directly ubiquitylates a substrate to recruit RAP80 or acts as a scaffold not resolved
    • Relationship between PCNA-binding and damage-site recruitment functions unclear
  8. 2019 High

    Reconstitution of TRAIP-dependent ICL repair pathway choice—where ubiquitin chain length on CMG helicase determines NEIL3 versus Fanconi anemia pathway engagement—and parallel demonstration that TRAIP drives mitotic replisome disassembly via K6/K63-linked chains on MCM7 with p97 extraction, established the unified mechanism by which TRAIP controls replisome fate.

    Evidence Xenopus egg extract reconstitution with ubiquitin chain analysis, CMG unloading assays, p97 inhibition; cross-species validation in C. elegans and human cells with DNA fiber and segregation assays

    PMID:30842657 PMID:30979826 PMID:31545170

    Open questions at the time
    • How TRAIP is activated specifically at converged forks versus mitotic replisomes not known
    • Structural basis of chain-length-dependent pathway switching unresolved
  9. 2021 High

    Epistasis experiments distinguishing CUL2-LRR1 (S-phase) from TRAIP (mitotic) CMG disassembly pathways in mammalian cells confirmed two-pathway replisome removal, while identification of KANK1 as a TRAIP substrate linked TRAIP to AKT signaling in osteosarcoma.

    Evidence Auxin-inducible degron in mouse ES cells with chromatin fractionation; co-immunoprecipitation and ubiquitination assays with KANK1 in osteosarcoma cells

    PMID:33590678 PMID:34349117

    Open questions at the time
    • Whether KANK1 ubiquitylation occurs at replication forks or independently unknown
    • TRAIP activation mechanism during mitosis versus S-phase not dissected
  10. 2023 High

    Precise temporal depletion revealed that TRAIP's essential S-phase function is preventing DNA damage at transcription start sites from replication-transcription conflicts, with loss causing G2 arrest and senescence rather than mitotic failure.

    Evidence Auxin-inducible degron for cell-cycle-specific TRAIP depletion, γH2AX mapping to transcription start sites, senescence assays

    PMID:37604812

    Open questions at the time
    • Direct substrate at replication-transcription conflict sites not identified
    • Whether conflict resolution involves CMG ubiquitylation or a distinct mechanism unclear

Open questions

Synthesis pass · forward-looking unresolved questions
  • The structural basis for TRAIP's regulation, its activation at converged versus stalled forks, the mechanism by which ubiquitin chain length is controlled to determine repair pathway choice, and the identity of TRAIP substrates at replication-transcription conflict sites remain unresolved.
  • No structural model of TRAIP or TRAIP-CMG complex
  • Mechanism controlling ubiquitin chain length on CMG unknown
  • Substrate at replication-transcription conflicts not identified
  • Relationship between NF-κB/innate immunity functions and replication functions in vivo not integrated

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 6 GO:0016874 ligase activity 3
Localization
GO:0005634 nucleus 3 GO:0005694 chromosome 2 GO:0005730 nucleolus 2
Pathway
R-HSA-1640170 Cell Cycle 4 R-HSA-392499 Metabolism of proteins 4 R-HSA-69306 DNA Replication 4 R-HSA-73894 DNA Repair 4 R-HSA-162582 Signal Transduction 3 R-HSA-168256 Immune System 1
Partners
CYLDKANK1MCM7PCNAPOLHRAP80TBK1TRAF2

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1997 TRAIP (TRIP) was identified as a novel component of TNFR2 and CD30 signaling complexes that associates with TRAF proteins and inhibits TRAF2-mediated NF-κB activation, containing a RING finger motif and an extended coiled-coil domain. Protein interaction studies (yeast two-hybrid, co-immunoprecipitation), NF-κB reporter assays The Journal of experimental medicine High 9104814
2007 TRAIP (TRIP) is a RING-dependent E3 ubiquitin ligase that undergoes auto-ubiquitination; intact RING domain is required for ligase activity. TRIP interacts with TRAF1, 2, 3, 5, and 6 but not CYLD or NIK. In vitro ubiquitination assay, RING domain mutagenesis, co-immunoprecipitation Biochemical and biophysical research communications High 17544371
2003 TRAIP (TRIP) interacts with the tumor suppressor CYLD through its C-terminal domain; CYLD's central domain binds TRIP's C-terminal end, and this interaction contributes to down-regulation of NF-κB activation by TNF-α. Yeast two-hybrid screen, far-Western analysis, co-immunoprecipitation in mammalian cells, NF-κB reporter assays The Journal of experimental medicine High 14676304
2007 TRAIP (TRIP) is essential for early embryonic development; homozygous TRIP-deficient mouse embryos die shortly after implantation due to proliferation defects and excessive cell death. Gene knockout in mice, embryo phenotyping Biochemical and biophysical research communications High 17927961
2012 TRAIP (TRIP) promotes proteasomal degradation of TBK1 by directly binding TBK1 and promoting K48-linked polyubiquitination, thereby negatively regulating TLR3/4- and RIG-I-induced IFN-β production and antiviral responses. Co-immunoprecipitation, ubiquitination assays, siRNA knockdown/overexpression, IRF3 activation assays, viral replication assays The Journal of experimental medicine High 22945920
2014 TRAIP is a nucleolar E3 ubiquitin ligase that localizes close to mitotic chromosomes; its depletion decreases early mitosis progression time, increases chromosome alignment defects and lagging chromosomes, and reduces MAD2 levels at kinetochores — effects requiring intact ubiquitin ligase activity. RNAi knockdown in HeLa cells, live cell imaging, immunofluorescence, rescue with WT vs. ligase-dead TRAIP Journal of cell science High 25335891
2015 TRAIP is a PCNA-binding E3 ubiquitin ligase that interacts directly with PCNA via a conserved PIP box motif and promotes ATR-dependent checkpoint signaling by facilitating RPA-bound single-stranded DNA generation upon replication stress; loss of TRAIP causes chromosomal instability. Co-immunoprecipitation, PIP box mutagenesis, ATR/RPA2 phosphorylation assays, chromosomal instability assays, siRNA knockdown The Journal of cell biology High 26711499
2015 Mutations in TRAIP (an E3 RING ubiquitin ligase) cause microcephalic primordial dwarfism; TRAIP relocalizes to sites of DNA damage where it is required for optimal phosphorylation of H2AX and RPA2 during S-phase in response to UV irradiation, and is necessary for fork progression through UV-induced lesions. Human genetics, patient-derived cells, immunofluorescence/live imaging of damage recruitment, H2AX/RPA2 phosphorylation assays, DNA fiber assays Nature genetics High 26595769
2016 TRAIP (RNF206) is required for recruitment of RAP80 to DNA damage sites; TRAIP acts upstream of RAP80, and the N-terminus of TRAIP mediates RAP80 interaction while the C-terminus mediates TRAIP localization to damage sites through direct interaction with RNF20-RNF40. TRAIP promotes homologous recombination and BRCA1 accumulation at damage sites. Co-immunoprecipitation, domain mapping, siRNA knockdown, immunofluorescence at DNA damage foci Nature communications High 26781088
2016 TRAIP (RNF206) interacts with PCNA via a conserved PIP box on its C-terminus, localizes to stalled replication forks as a nucleolar protein, and is required for replication fork recovery and progression; inactivation of TRAIP or its PCNA interaction leads to chromosome instability. Co-immunoprecipitation, PIP box mutagenesis, DNA fiber assay, chromosomal instability assays Cell discovery Medium 27462463
2019 TRAIP is the master E3 ubiquitin ligase controlling replication-coupled interstrand crosslink (ICL) repair pathway choice: when two replisomes converge at an ICL, TRAIP ubiquitylates the CMG helicase; short ubiquitin chains recruit NEIL3 glycosylase (simpler pathway) while longer chains trigger CMG unloading by p97 ATPase enabling the Fanconi anemia pathway. Xenopus egg extract reconstitution, ubiquitin chain analysis, CMG unloading assays, NEIL3 binding assays, p97 inhibition, TRAIP depletion/add-back Nature High 30842657
2019 TRAIP ubiquitin ligase drives replisome disassembly in response to incomplete DNA replication during mitosis (MiDAS); TRAIP is essential for mitotic DNA repair synthesis in human cells and prevents mitotic segregation errors. C. elegans genetics, human cell siRNA knockdown, DNA fiber assay, chromosome segregation analysis eLife High 31545170
2019 Mitotic replisome disassembly depends on TRAIP ubiquitin ligase activity: in Xenopus egg extracts, TRAIP forms K6- and K63-linked ubiquitin chains on Mcm7, and p97/VCP protein segregase is required for subsequent chromatin extraction of replisomes retained until mitosis. Xenopus egg extract reconstitution, ubiquitin chain linkage analysis (K6/K63), p97 inhibition, chromatin fractionation Life science alliance High 30979826
2021 TRAIP ubiquitin ligase mediates a second CMG disassembly pathway during mitosis in mammalian cells; CUL2LRR1 ubiquitylates CMG-MCM7 during S-phase for p97-dependent disassembly, while TRAIP activates a distinct mitotic CMG disassembly pathway in mouse embryonic stem cells. Mouse embryonic stem cell model, auxin-inducible degron system, chromatin fractionation, ubiquitylation assays EMBO reports High 33590678
2021 TRAIP promotes KANK1 polyubiquitination and subsequent degradation, which downregulates IGFBP3 and activates the AKT pathway in osteosarcoma cells, enhancing invasion and proliferation. Co-immunoprecipitation, ubiquitination assays, siRNA knockdown/overexpression, AKT pathway analysis, invasion/proliferation assays Cell death & disease Medium 34349117
2015 TRAIP dimerizes through its coiled-coil (CC) domain; cells expressing a CC domain-deleted mutant unable to form homodimers show increased mitotic index and altered mitotic progression. Co-immunoprecipitation with deletion mutants, mitotic index analysis Biochemical and biophysical research communications Medium 26093298
2014 TRAIP/NOPO E3 ubiquitin ligase promotes ubiquitylation of DNA polymerase η (Polη) to positively regulate its activity in translesion synthesis; TRIP and NOPO co-immunoprecipitate with human and Drosophila Polη, and genetic interaction was confirmed by overexpression of dPolη suppressing nopo phenotypes. Yeast two-hybrid, co-immunoprecipitation, ubiquitination assays, Drosophila genetics (null mutation, overexpression epistasis), UV sensitivity assays Development (Cambridge, England) High 24553286
2010 TRAIP (TRIP) is required for keratinocyte proliferation; TRIP knockdown causes G1/S growth arrest, increased expression of differentiation markers (keratin 1, filaggrin), and reduced proliferation; these effects are independent of NF-κB activity in keratinocytes. Lentiviral shRNA knockdown, cell cycle analysis (FACS), differentiation marker immunofluorescence, NF-κB reporter assay The Journal of investigative dermatology Medium 21068752
2009 TRAIP (TRIP) interacts with the protein-tyrosine kinase Syk via its C-terminal region; this interaction is enhanced by TNF and Syk tyrosine phosphorylation. Syk and TRIP have opposing functions in NF-κB activation by TNF: Syk enhances NF-κB activation while TRIP inhibits it. Yeast two-hybrid screen, co-immunoprecipitation, NF-κB reporter assays, TNF-induced apoptosis assays Oncogene Medium 19151749
2023 TRAIP works specifically in S-phase to prevent DNA damage at transcription start sites caused by replication-transcription conflicts; rapid TRAIP degradation in S-phase causes cells to arrest in G2 and undergo senescence, while TRAIP depletion in other cell cycle phases does not have the same effect. Auxin-inducible degron (AID) system for cell-cycle-specific TRAIP depletion, DNA damage markers (γH2AX), transcription start site analysis, cell cycle analysis, senescence assays Nature communications High 37604812

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2004 A trip to the ER: coping with stress. Trends in cell biology 1186 14729177
2009 The trip of the tip: understanding the growth cone machinery. Nature reviews. Molecular cell biology 572 19373241
2016 Enjoy the Trip: Calcium in Mitochondria Back and Forth. Annual review of biochemistry 336 27145841
2009 Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been. Genes & development 215 19933148
2009 Laminopathies and the long strange trip from basic cell biology to therapy. The Journal of clinical investigation 214 19587457
2005 TRP channels: a TR(I)P through a world of multifunctional cation channels. Pflugers Archiv : European journal of physiology 183 16012814
2019 FOXO3a from the Nucleus to the Mitochondria: A Round Trip in Cellular Stress Response. Cells 178 31546924
1999 Galectins: an evolutionarily conserved family of animal lectins with multifunctional properties; a trip from the gene to clinical therapy. Cell death and differentiation 173 10467344
1997 TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation. The Journal of experimental medicine 171 9104814
1995 Environmental virology: from detection of virus in sewage and water by isolation to identification by molecular biology--a trip of over 50 years. Annual review of microbiology 164 8561468
2021 Pathogenicity and virulence of Listeria monocytogenes: A trip from environmental to medical microbiology. Virulence 151 34612177
2019 TRAIP is a master regulator of DNA interstrand crosslink repair. Nature 149 30842657
2016 BDNF isoforms: a round trip ticket between neurogenesis and serotonin? Journal of neurochemistry 148 27167299
2013 Tip growth in filamentous fungi: a road trip to the apex. Annual review of microbiology 141 23808332
2008 A forest bathing trip increases human natural killer activity and expression of anti-cancer proteins in female subjects. Journal of biological regulators and homeostatic agents 125 18394317
2022 Phloem Loading and Unloading of Sucrose: What a Long, Strange Trip from Source to Sink. Annual review of plant biology 121 35171647
2012 TRAF-interacting protein (TRIP) negatively regulates IFN-β production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1. The Journal of experimental medicine 117 22945920
2008 Ligand customization and DNA functionalization of gold nanorods via round-trip phase transfer ligand exchange. Langmuir : the ACS journal of surfaces and colloids 116 18717601
2010 Carbonic anhydrase inhibition/activation: trip of a scientist around the world in the search of novel chemotypes and drug targets. Current pharmaceutical design 114 20819070
2001 TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. The EMBO journal 102 11331592
2003 The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor. The Journal of experimental medicine 101 14676304
1998 The type II transforming growth factor (TGF)-beta receptor-interacting protein TRIP-1 acts as a modulator of the TGF-beta response. The Journal of biological chemistry 101 9813058
2014 MeCP2: the long trip from a chromatin protein to neurological disorders. Trends in molecular medicine 83 24766768
2018 Acid growth: an ongoing trip. Journal of experimental botany 79 29211894
2015 TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism. Nature genetics 77 26595769
2013 Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. Nature medicine 75 23291629
2019 A TR(i)P to Cell Migration: New Roles of TRP Channels in Mechanotransduction and Cancer. Frontiers in physiology 73 31275168
2019 TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication. eLife 66 31545170
2021 α-Synuclein: An All-Inclusive Trip Around its Structure, Influencing Factors and Applied Techniques. Frontiers in chemistry 65 34307295
2015 TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress. The Journal of cell biology 62 26711499
2010 Hypercoagulability, platelet function, inflammation and coronary artery disease acuity: results of the Thrombotic RIsk Progression (TRIP) study. Platelets 62 20377327
2010 A day trip to a forest park increases human natural killer activity and the expression of anti-cancer proteins in male subjects. Journal of biological regulators and homeostatic agents 58 20487629
2014 A trip in the "New Microbiology" with the bacterial pathogen Listeria monocytogenes. FEBS letters 57 24911203
2021 Bone-to-Brain: A Round Trip in the Adaptation to Mechanical Stimuli. Frontiers in physiology 54 33995117
2014 New insights into pharmacological tools to TR(i)P cancer up. British journal of pharmacology 53 24345078
2019 The RANKL-RANK Axis: A Bone to Thymus Round Trip. Frontiers in immunology 49 30984193
2009 A TR(I)P to pruritus research: role of TRPV3 in inflammation and itch. The Journal of investigative dermatology 49 19209153
2011 Therapeutic targeting of TRP channels--the TR(i)P to pain relief. Current topics in medicinal chemistry 47 21671881
1998 TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I. Nucleic acids research 46 9671805
2019 Mitotic replisome disassembly depends on TRAIP ubiquitin ligase activity. Life science alliance 44 30979826
2009 The protein-tyrosine kinase Syk interacts with TRAF-interacting protein TRIP in breast epithelial cells. Oncogene 43 19151749
2021 Supplying the trip to antibody production-nutrients, signaling, and the programming of cellular metabolism in the mature B lineage. Cellular & molecular immunology 42 34782762
2016 The obesity-induced transcriptional regulator TRIP-Br2 mediates visceral fat endoplasmic reticulum stress-induced inflammation. Nature communications 42 27109496
2011 From hydra regeneration to human brain structural plasticity: a long trip through narrowing roads. TheScientificWorldJournal 42 21666994
2007 Early embryonic lethality caused by targeted disruption of the TRAF-interacting protein (TRIP) gene. Biochemical and biophysical research communications 41 17927961
2020 Allogeneic cord blood transfusions prevent fetal haemoglobin depletion in preterm neonates. Results of the CB-TrIP study. British journal of haematology 40 32510635
2018 PIK3IP1/TrIP restricts activation of T cells through inhibition of PI3K/Akt. The Journal of experimental medicine 40 30429249
2016 TRAIP/RNF206 is required for recruitment of RAP80 to sites of DNA damage. Nature communications 40 26781088
2005 How to pack the genome for a safe trip. Progress in molecular and subcellular biology 38 15881891
2016 TRAIP regulates replication fork recovery and progression via PCNA. Cell discovery 36 27462463
2019 Metabolic reconstruction of the genome of candidate Desulfatiglans TRIP_1 and identification of key candidate enzymes for anaerobic phenanthrene degradation. Environmental microbiology 34 30680888
2014 Using TRIP for genome-wide position effect analysis in cultured cells. Nature protocols 33 24810036
2021 CUL2LRR1 , TRAIP and p97 control CMG helicase disassembly in the mammalian cell cycle. EMBO reports 32 33590678
2021 TRAIP modulates the IGFBP3/AKT pathway to enhance the invasion and proliferation of osteosarcoma by promoting KANK1 degradation. Cell death & disease 31 34349117
2020 LncRNA SLC7A11-AS1 Contributes to Lung Cancer Progression Through Facilitating TRAIP Expression by Inhibiting miR-4775. OncoTargets and therapy 31 32636648
2007 TRAF-interacting protein (TRIP) is a RING-dependent ubiquitin ligase. Biochemical and biophysical research communications 31 17544371
2018 Shiga toxin-producing Escherichia coli O103:H2 outbreak in Germany after school trip to Austria due to raw cow milk, 2017 - The important role of international collaboration for outbreak investigations. International journal of medical microbiology : IJMM 29 29884330
2018 Establishing life is a calcium-dependent TRiP: Transient receptor potential channels in reproduction. Biochimica et biophysica acta. Molecular cell research 29 30798946
2012 Taking a cellular road-trip: mRNA transport and anchoring. Current opinion in cell biology 29 23200723
2020 The Ubiquitin Ligase TRAIP: Double-Edged Sword at the Replisome. Trends in cell biology 28 33317933
2018 Transient receptor potential (TRP) channels: a metabolic TR(i)P to obesity prevention and therapy. Obesity reviews : an official journal of the International Association for the Study of Obesity 28 29797770
2009 A nonself RNA pattern: tri-p to panhandle. Immunity 28 19604485
2008 Brain TRPV1: a depressing TR(i)P down memory lane? Trends in pharmacological sciences 28 18947889
2010 The TRAF-interacting protein (TRIP) is a regulator of keratinocyte proliferation. The Journal of investigative dermatology 27 21068752
2008 The long strange trip of Borrelia burgdorferi outer-surface protein C. Molecular microbiology 27 18399935
2022 Benefits of Taking a Virtual Field Trip in Immersive Virtual Reality: Evidence for the Immersion Principle in Multimedia Learning. Educational psychology review 26 35475019
2020 tRIP-seq reveals repression of premature polyadenylation by co-transcriptional FUS-U1 snRNP assembly. EMBO reports 26 32189459
2014 TRAIP is a regulator of the spindle assembly checkpoint. Journal of cell science 26 25335891
2006 Transcriptional and subcellular regulation of the TRIP-Br family. Gene 26 17141982
2017 Enhancing titres of therapeutic viral vectors using the transgene repression in vector production (TRiP) system. Nature communications 24 28345582
2014 TRIP/NOPO E3 ubiquitin ligase promotes ubiquitylation of DNA polymerase η. Development (Cambridge, England) 24 24553286
2014 One-way trip: influenza virus' adaptation to gallinaceous poultry may limit its pandemic potential. BioEssays : news and reviews in molecular, cellular and developmental biology 24 25546511
2007 Where do animal alpha-amylases come from? An interkingdom trip. FEBS letters 24 17662722
2004 Leukocyte circulation: one-way or round-trip? Lessons from primary immunodeficiency patients. Journal of leukocyte biology 24 15075352
2019 A Genetic Screen Using the Drosophila melanogaster TRiP RNAi Collection To Identify Metabolic Enzymes Required for Eye Development. G3 (Bethesda, Md.) 23 31036678
2013 A force-activated trip switch triggers rapid dissociation of a colicin from its immunity protein. PLoS biology 23 23431269
2021 β3-Adrenoceptor, a novel player in the round-trip from neonatal diseases to cancer: Suggestive clues from embryo. Medicinal research reviews 21 34967048
2015 TRIP-Br1 oncoprotein inhibits autophagy, apoptosis, and necroptosis under nutrient/serum-deprived condition. Oncotarget 21 26334958
2009 TRIP-Br2 promotes oncogenesis in nude mice and is frequently overexpressed in multiple human tumors. Journal of translational medicine 21 19152710
2004 TRIP-Br links E2F to novel functions in the regulation of cyclin E expression during cell cycle progression and in the maintenance of genomic stability. Cell cycle (Georgetown, Tex.) 21 15467469
1999 A comparison of thick smears, QBC malaria, PCR and PATH falciparum malaria test trip in Plasmodium falciparum diagnosis. Parasite (Paris, France) 21 10511977
2011 TRIP-1 regulates TGF-β1-induced epithelial-mesenchymal transition of human lung epithelial cell line A549. American journal of physiology. Lung cellular and molecular physiology 20 21378021
2010 TRIP Database: a manually curated database of protein-protein interactions for mammalian TRP channels. Nucleic acids research 20 20851834
2021 A TRiP Through the Roles of Transient Receptor Potential Cation Channels in Type 2 Upper Airway Inflammation. Current allergy and asthma reports 19 33738577
2017 The complex of TRIP-Br1 and XIAP ubiquitinates and degrades multiple adenylyl cyclase isoforms. eLife 19 28656888
2015 Nutrient/serum starvation derived TRIP-Br3 down-regulation accelerates apoptosis by destabilizing XIAP. Oncotarget 19 25691055
2017 Perspectives on cardiovascular effects of incretin-based drugs: From bedside to bench, return trip. International journal of cardiology 18 28285800
2021 A Round Trip to the Desert: In situ Nanopore Sequencing Informs Targeted Bioprospecting. Frontiers in microbiology 17 34966365
2020 TRIP - T cell receptor/immunoglobulin profiler. BMC bioinformatics 16 32993478
2019 Recognition of TRAIP with TRAFs: Current understanding and associated diseases. The international journal of biochemistry & cell biology 16 31442608
2012 TRIP-1: a regulator of osteoblast function. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 16 22460930
2010 The TRIP from ULF to ARF. Cancer cell 16 20385357
2006 The TRIP-Br family of transcriptional regulators is essential for the execution of cyclin E-mediated cell cycle progression. Cell cycle (Georgetown, Tex.) 16 16721052
2023 TRAIP resolves DNA replication-transcription conflicts during the S-phase of unperturbed cells. Nature communications 15 37604812
2017 T3SS-Independent Uptake of the Short-Trip Toxin-Related Recombinant NleC Effector of Enteropathogenic Escherichia coli Leads to NF-κB p65 Cleavage. Frontiers in cellular and infection microbiology 15 28451521
2016 Apicomplexa-specific tRip facilitates import of exogenous tRNAs into malaria parasites. Proceedings of the National Academy of Sciences of the United States of America 15 27071116
2014 You never know when your last day will come and your trip will be over--existential expressions from a melanoma diagnosis. European journal of oncology nursing : the official journal of European Oncology Nursing Society 15 24785793
1997 Expression of co-factors (SMRT and Trip-1) for retinoic acid receptors in human neuroectodermal cell lines. Biochemical and biophysical research communications 15 9169003
2015 Dimerization of TRAF-interacting protein (TRAIP) regulates the mitotic progression. Biochemical and biophysical research communications 14 26093298
2008 Identification of PP2A as a novel interactor and regulator of TRIP-Br1. Cellular signalling 14 18940248